TB-Profiler

Lineage	Family	RDs	Frequency
La1.2.BCG	M.bovis	None	0.07
lineage4.9	Euro-American (H37Rv-like)	None	0.89
lineage6.2.1	West-Africa 2	RD702	0.07

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
fbiC	1303789	c.859_861delATCinsGG	frameshift_variant&missense_variant	0.85	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
rrs	1472307	n.462C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance	Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	795	c.795A>C	synonymous_variant	0.7	isoniazid	Not assoc w R - Interim
dnaA	805	c.805_807delTTGinsCC	frameshift_variant&missense_variant	0.73	isoniazid	Uncertain significance
dnaA	819	c.819C>T	synonymous_variant	0.73	isoniazid
dnaA	822	c.822A>G	synonymous_variant	0.73	isoniazid
dnaA	828	c.828T>C	synonymous_variant	0.73	isoniazid	Not assoc w R - Interim
dnaA	831	c.831A>G	synonymous_variant	0.73	isoniazid
dnaA	837	c.837A>G	synonymous_variant	0.73	isoniazid
dnaA	840	c.840G>A	synonymous_variant	0.73	isoniazid
dnaA	846	c.846T>C	synonymous_variant	0.73	isoniazid
dnaA	849	c.849A>G	synonymous_variant	0.55	isoniazid
dnaA	852	c.852G>A	synonymous_variant	0.73	isoniazid	Not assoc w R - Interim
dnaA	1137	c.1137C>G	synonymous_variant	1.0	isoniazid
dnaA	1143	c.1143G>C	synonymous_variant	0.92	isoniazid
dnaA	1152	c.1152A>G	synonymous_variant	0.91	isoniazid
dnaA	1153	c.1153T>C	synonymous_variant	0.91	isoniazid
dnaA	1161	c.1161A>G	synonymous_variant	0.9	isoniazid
dnaA	1164	c.1164A>C	synonymous_variant	0.9	isoniazid
dnaA	1167	c.1167A>G	synonymous_variant	0.9	isoniazid	Not assoc w R - Interim
dnaA	1188	c.1188G>A	synonymous_variant	0.9	isoniazid
dnaA	1191	c.1191T>C	synonymous_variant	0.9	isoniazid
dnaA	1197	c.1197T>C	synonymous_variant	0.92	isoniazid	Not assoc w R - Interim
dnaA	1204	c.1204C>T	synonymous_variant	0.92	isoniazid
dnaA	1220	p.Asn407Ser	missense_variant	0.83	isoniazid
dnaA	1230	c.1230A>G	synonymous_variant	0.85	isoniazid
dnaA	1236	c.1236C>T	synonymous_variant	0.86	isoniazid
dnaA	1242	c.1242G>C	synonymous_variant	0.85	isoniazid
dnaA	1245	c.1245G>C	synonymous_variant	0.85	isoniazid	Not assoc w R - Interim
dnaA	1254	c.1254T>C	synonymous_variant	0.87	isoniazid
dnaA	1278	c.1278T>C	synonymous_variant	0.79	isoniazid
dnaA	1284	c.1284C>G	synonymous_variant	0.86	isoniazid
dnaA	1290	c.1290G>A	synonymous_variant	0.85	isoniazid
dnaA	1293	c.1293T>C	synonymous_variant	0.92	isoniazid
dnaA	1299	c.1299G>C	synonymous_variant	0.92	isoniazid	Not assoc w R - Interim
dnaA	1302	c.1302C>G	synonymous_variant	0.92	isoniazid
dnaA	1311	c.1311C>G	synonymous_variant	0.92	isoniazid
dnaA	1314	c.1314A>G	synonymous_variant	0.92	isoniazid
dnaA	1317	c.1317A>G	synonymous_variant	0.92	isoniazid
dnaA	1320	c.1320G>C	synonymous_variant	0.93	isoniazid
dnaA	1332	c.1332A>C	synonymous_variant	0.94	isoniazid	Not assoc w R - Interim
dnaA	1338	c.1338T>C	synonymous_variant	0.94	isoniazid
dnaA	1353	c.1353T>C	synonymous_variant	0.94	isoniazid
dnaA	1371	c.1371T>G	synonymous_variant	1.0	isoniazid
dnaA	1375	c.1375T>C	synonymous_variant	1.0	isoniazid
dnaA	1383	c.1383A>G	synonymous_variant	1.0	isoniazid
dnaA	1389	c.1389C>G	synonymous_variant	1.0	isoniazid
dnaA	1392	c.1392A>G	synonymous_variant	1.0	isoniazid
dnaA	1395	c.1395G>C	synonymous_variant	1.0	isoniazid
dnaA	1404	c.1404T>C	synonymous_variant	1.0	isoniazid
dnaA	1407	c.1407T>C	synonymous_variant	1.0	isoniazid
dnaA	1413	c.1413A>C	synonymous_variant	1.0	isoniazid
dnaA	1416	c.1416C>G	synonymous_variant	0.93	isoniazid
dnaA	1428	c.1428C>G	synonymous_variant	1.0	isoniazid
dnaA	1449	c.1449G>A	synonymous_variant	0.92	isoniazid
dnaA	1455	c.1455C>A	synonymous_variant	0.62	isoniazid	Not assoc w R - Interim
dnaA	1461	c.1461C>G	synonymous_variant	1.0	isoniazid
dnaA	1470	c.1470C>T	synonymous_variant	1.0	isoniazid
gyrB	6196	c.957C>T	synonymous_variant	0.58	levofloxacin
gyrB	6196	c.957C>T	synonymous_variant	0.58	moxifloxacin
gyrB	6238	c.999G>A	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6238	c.999G>A	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6242	p.Arg335Lys	missense_variant	1.0	levofloxacin
gyrB	6242	p.Arg335Lys	missense_variant	1.0	moxifloxacin
gyrB	6256	c.1017G>A	synonymous_variant	0.92	levofloxacin
gyrB	6256	c.1017G>A	synonymous_variant	0.92	moxifloxacin
gyrB	6268	c.1029C>G	synonymous_variant	0.94	levofloxacin
gyrB	6268	c.1029C>G	synonymous_variant	0.94	moxifloxacin
gyrB	6280	c.1041T>C	synonymous_variant	1.0	levofloxacin
gyrB	6280	c.1041T>C	synonymous_variant	1.0	moxifloxacin
gyrB	6286	c.1047T>C	synonymous_variant	1.0	levofloxacin
gyrB	6286	c.1047T>C	synonymous_variant	1.0	moxifloxacin
gyrB	6289	c.1050C>T	synonymous_variant	0.94	levofloxacin
gyrB	6289	c.1050C>T	synonymous_variant	0.94	moxifloxacin
gyrB	6292	c.1053G>C	synonymous_variant	1.0	levofloxacin
gyrB	6292	c.1053G>C	synonymous_variant	1.0	moxifloxacin
gyrB	6307	c.1068T>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6307	c.1068T>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6319	c.1080G>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6319	c.1080G>C	synonymous_variant	1.0	moxifloxacin
gyrA	6673	c.-629A>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6673	c.-629A>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	6676	c.-626T>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6676	c.-626T>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	6904	c.-398C>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6904	c.-398C>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	6910	c.-392G>A	upstream_gene_variant	1.0	levofloxacin
gyrA	6910	c.-392G>A	upstream_gene_variant	1.0	moxifloxacin
gyrB	6919	c.1680T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6919	c.1680T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	6925	c.-377T>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6925	c.-377T>C	upstream_gene_variant	1.0	moxifloxacin
gyrB	6931	c.1692A>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6931	c.1692A>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	7051	p.Glu604Asp	missense_variant	1.0	levofloxacin
gyrB	7051	p.Glu604Asp	missense_variant	1.0	moxifloxacin
gyrA	7066	c.-236G>C	upstream_gene_variant	1.0	levofloxacin
gyrA	7066	c.-236G>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	7078	c.-224A>C	upstream_gene_variant	1.0	levofloxacin
gyrA	7078	c.-224A>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	7084	c.-218A>G	upstream_gene_variant	1.0	levofloxacin
gyrA	7084	c.-218A>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	7090	c.-212C>T	upstream_gene_variant	1.0	levofloxacin
gyrA	7090	c.-212C>T	upstream_gene_variant	1.0	moxifloxacin
gyrA	7093	c.-209T>G	upstream_gene_variant	1.0	levofloxacin
gyrA	7093	c.-209T>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	7099	c.-203G>A	upstream_gene_variant	1.0	levofloxacin
gyrA	7099	c.-203G>A	upstream_gene_variant	1.0	moxifloxacin
gyrA	7108	c.-194G>A	upstream_gene_variant	1.0	levofloxacin
gyrA	7108	c.-194G>A	upstream_gene_variant	1.0	moxifloxacin
gyrA	7114	c.-188C>A	upstream_gene_variant	1.0	levofloxacin
gyrA	7114	c.-188C>A	upstream_gene_variant	1.0	moxifloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.91	levofloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.91	moxifloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.91	levofloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.91	moxifloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.91	levofloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.91	moxifloxacin
gyrA	8198	c.897T>C	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrA	8198	c.897T>C	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrA	8207	c.906T>C	synonymous_variant	0.92	levofloxacin
gyrA	8207	c.906T>C	synonymous_variant	0.92	moxifloxacin
gyrA	8219	c.918T>C	synonymous_variant	0.93	levofloxacin	Not assoc w R - Interim
gyrA	8219	c.918T>C	synonymous_variant	0.93	moxifloxacin	Not assoc w R - Interim
gyrA	8225	c.924T>C	synonymous_variant	0.93	levofloxacin
gyrA	8225	c.924T>C	synonymous_variant	0.93	moxifloxacin
gyrA	8234	c.933T>C	synonymous_variant	0.93	levofloxacin
gyrA	8234	c.933T>C	synonymous_variant	0.93	moxifloxacin
gyrA	8237	c.936A>G	synonymous_variant	0.93	levofloxacin
gyrA	8237	c.936A>G	synonymous_variant	0.93	moxifloxacin
gyrA	8247	c.946_948delATCinsGG	frameshift_variant&missense_variant	0.94	levofloxacin
gyrA	8247	c.946_948delATCinsGG	frameshift_variant&missense_variant	0.94	moxifloxacin
gyrA	8264	c.963T>C	synonymous_variant	1.0	levofloxacin
gyrA	8264	c.963T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8267	c.966G>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8267	c.966G>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8270	c.969G>C	synonymous_variant	1.0	levofloxacin
gyrA	8270	c.969G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8276	c.975G>A	synonymous_variant	1.0	levofloxacin
gyrA	8276	c.975G>A	synonymous_variant	1.0	moxifloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	1.0	levofloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	1.0	moxifloxacin
gyrA	8288	c.987T>C	synonymous_variant	0.46	levofloxacin	Not assoc w R - Interim
gyrA	8288	c.987T>C	synonymous_variant	0.46	moxifloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8324	c.1023T>C	synonymous_variant	1.0	levofloxacin
gyrA	8324	c.1023T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8330	c.1029C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8330	c.1029C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8339	c.1038A>G	synonymous_variant	1.0	levofloxacin
gyrA	8339	c.1038A>G	synonymous_variant	1.0	moxifloxacin
gyrA	8340	p.Ala347Ser	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	8340	p.Ala347Ser	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	8372	c.1071G>C	synonymous_variant	1.0	levofloxacin
gyrA	8372	c.1071G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8375	c.1074G>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8375	c.1074G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8588	c.1287G>A	synonymous_variant	1.0	levofloxacin
gyrA	8588	c.1287G>A	synonymous_variant	1.0	moxifloxacin
gyrA	8597	c.1296C>G	synonymous_variant	1.0	levofloxacin
gyrA	8597	c.1296C>G	synonymous_variant	1.0	moxifloxacin
gyrA	8672	c.1371A>G	synonymous_variant	0.9	levofloxacin	Not assoc w R - Interim
gyrA	8672	c.1371A>G	synonymous_variant	0.9	moxifloxacin	Not assoc w R - Interim
gyrA	8729	c.1428T>C	synonymous_variant	0.92	levofloxacin
gyrA	8729	c.1428T>C	synonymous_variant	0.92	moxifloxacin
gyrA	8730	p.Gly477Arg	missense_variant	0.92	levofloxacin	Uncertain significance
gyrA	8730	p.Gly477Arg	missense_variant	0.92	moxifloxacin
gyrA	8740	p.Arg480His	missense_variant	0.92	levofloxacin
gyrA	8740	p.Arg480His	missense_variant	0.92	moxifloxacin
gyrA	8747	c.1446A>G	synonymous_variant	0.92	levofloxacin
gyrA	8747	c.1446A>G	synonymous_variant	0.92	moxifloxacin
gyrA	8750	c.1449C>G	synonymous_variant	0.92	levofloxacin
gyrA	8750	c.1449C>G	synonymous_variant	0.92	moxifloxacin
gyrA	8751	p.Ala484Ser	missense_variant	0.92	levofloxacin
gyrA	8751	p.Ala484Ser	missense_variant	0.92	moxifloxacin
gyrA	8756	c.1455A>G	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrA	8756	c.1455A>G	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrA	8762	c.1461G>C	synonymous_variant	0.85	levofloxacin	Not assoc w R - Interim
gyrA	8762	c.1461G>C	synonymous_variant	0.85	moxifloxacin	Not assoc w R - Interim
gyrA	8767	p.Arg489Lys	missense_variant	0.85	levofloxacin	Uncertain significance
gyrA	8767	p.Arg489Lys	missense_variant	0.85	moxifloxacin	Uncertain significance
gyrA	8780	p.Asp493Glu	missense_variant	0.86	levofloxacin
gyrA	8780	p.Asp493Glu	missense_variant	0.86	moxifloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.93	levofloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.93	moxifloxacin
gyrA	8801	c.1500G>C	synonymous_variant	0.93	levofloxacin
gyrA	8801	c.1500G>C	synonymous_variant	0.93	moxifloxacin
gyrA	8807	c.1506C>T	synonymous_variant	0.92	levofloxacin
gyrA	8807	c.1506C>T	synonymous_variant	0.92	moxifloxacin
gyrA	8810	c.1509A>G	synonymous_variant	0.92	levofloxacin
gyrA	8810	c.1509A>G	synonymous_variant	0.92	moxifloxacin
gyrA	8816	c.1515C>G	synonymous_variant	0.94	levofloxacin
gyrA	8816	c.1515C>G	synonymous_variant	0.94	moxifloxacin
gyrA	8818	p.Ser506Asn	missense_variant	0.94	levofloxacin	Uncertain significance
gyrA	8818	p.Ser506Asn	missense_variant	0.94	moxifloxacin	Uncertain significance
gyrA	8828	c.1527T>C	synonymous_variant	0.94	levofloxacin
gyrA	8828	c.1527T>C	synonymous_variant	0.94	moxifloxacin
gyrA	8837	c.1536C>T	synonymous_variant	0.94	levofloxacin
gyrA	8837	c.1536C>T	synonymous_variant	0.94	moxifloxacin
gyrA	8852	c.1551T>C	synonymous_variant	0.94	levofloxacin
gyrA	8852	c.1551T>C	synonymous_variant	0.94	moxifloxacin
gyrA	8858	c.1557T>C	synonymous_variant	0.93	levofloxacin
gyrA	8858	c.1557T>C	synonymous_variant	0.93	moxifloxacin
gyrA	8867	c.1566A>G	synonymous_variant	0.93	levofloxacin	Not assoc w R - Interim
gyrA	8867	c.1566A>G	synonymous_variant	0.93	moxifloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	0.93	levofloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	0.93	moxifloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>C	synonymous_variant	0.93	levofloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>C	synonymous_variant	0.93	moxifloxacin	Not assoc w R - Interim
gyrA	8891	c.1590G>A	synonymous_variant	0.59	levofloxacin
gyrA	8891	c.1590G>A	synonymous_variant	0.59	moxifloxacin
gyrA	8897	c.1596T>C	synonymous_variant	0.94	levofloxacin	Not assoc w R - Interim
gyrA	8897	c.1596T>C	synonymous_variant	0.94	moxifloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.94	levofloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.94	moxifloxacin	Not assoc w R - Interim
gyrA	8918	c.1617C>A	synonymous_variant	0.41	levofloxacin
gyrA	8918	c.1617C>A	synonymous_variant	0.41	moxifloxacin
gyrA	8933	c.1632G>C	synonymous_variant	1.0	levofloxacin
gyrA	8933	c.1632G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8939	c.1638T>C	synonymous_variant	1.0	levofloxacin
gyrA	8939	c.1638T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8942	c.1641G>C	synonymous_variant	1.0	levofloxacin
gyrA	8942	c.1641G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	1.0	levofloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	1.0	moxifloxacin
gyrA	9017	c.1716C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9017	c.1716C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9023	c.1722A>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9023	c.1722A>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9050	p.Asp583Glu	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	9050	p.Asp583Glu	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	9051	c.1750T>C	synonymous_variant	1.0	levofloxacin
gyrA	9051	c.1750T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9056	c.1755C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9056	c.1755C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9062	c.1761C>G	synonymous_variant	1.0	levofloxacin
gyrA	9062	c.1761C>G	synonymous_variant	1.0	moxifloxacin
gyrA	9068	c.1767G>C	synonymous_variant	1.0	levofloxacin
gyrA	9068	c.1767G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9071	c.1770G>C	synonymous_variant	1.0	levofloxacin
gyrA	9071	c.1770G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9080	c.1779G>T	synonymous_variant	1.0	levofloxacin
gyrA	9080	c.1779G>T	synonymous_variant	1.0	moxifloxacin
gyrA	9089	c.1788G>C	synonymous_variant	1.0	levofloxacin
gyrA	9089	c.1788G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9099	c.1798_1800delTTAinsCG	frameshift_variant&missense_variant	1.0	levofloxacin
gyrA	9099	c.1798_1800delTTAinsCG	frameshift_variant&missense_variant	1.0	moxifloxacin
gyrA	9104	c.1803C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9104	c.1803C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9119	c.1818A>G	synonymous_variant	1.0	levofloxacin
gyrA	9119	c.1818A>G	synonymous_variant	1.0	moxifloxacin
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9152	c.1851C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9152	c.1851C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9153	p.Thr618Glu	missense_variant	1.0	levofloxacin
gyrA	9153	p.Thr618Glu	missense_variant	1.0	moxifloxacin
gyrA	9158	c.1857C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9158	c.1857C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9161	c.1860C>G	synonymous_variant	1.0	levofloxacin
gyrA	9161	c.1860C>G	synonymous_variant	1.0	moxifloxacin
fgd1	490827	c.45C>T	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fgd1	490848	c.66A>G	synonymous_variant	0.92	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fgd1	490851	c.69A>T	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fgd1	490868	p.Ala29Gly	missense_variant	0.92	clofazimine
					pretomanid
					delamanid
fgd1	490887	c.105G>A	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490890	c.108C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490896	c.114C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490905	c.123T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490911	c.129T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490917	c.135C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490921	p.Gln47Glu	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490929	c.147C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490932	c.150T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490935	c.153C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490948	p.Ser56Ala	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	490962	c.180T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	491013	c.231C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	491043	c.261T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	491049	c.267T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	491601	c.819T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	491610	c.828A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	491616	c.834A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	491620	p.Ile280Val	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fgd1	491643	c.861G>A	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fgd1	491646	c.864G>C	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fgd1	491649	c.867C>T	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fgd1	491658	c.876A>G	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fgd1	491661	c.879C>G	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
mshA	575674	c.327G>C	synonymous_variant	0.91	ethionamide
mshA	575674	c.327G>C	synonymous_variant	0.91	isoniazid
mshA	575701	c.354G>A	synonymous_variant	0.8	ethionamide
mshA	575701	c.354G>A	synonymous_variant	0.8	isoniazid
mshA	575713	c.366G>A	synonymous_variant	0.82	ethionamide
mshA	575713	c.366G>A	synonymous_variant	0.82	isoniazid
mshA	575719	c.372C>T	synonymous_variant	0.86	ethionamide	Not assoc w R - Interim
mshA	575719	c.372C>T	synonymous_variant	0.86	isoniazid	Not assoc w R - Interim
mshA	575734	c.387T>G	synonymous_variant	0.92	ethionamide
mshA	575734	c.387T>G	synonymous_variant	0.92	isoniazid
mshA	575737	c.390T>C	synonymous_variant	0.87	ethionamide
mshA	575737	c.390T>C	synonymous_variant	0.87	isoniazid
mshA	575746	c.399C>G	synonymous_variant	0.93	ethionamide
mshA	575746	c.399C>G	synonymous_variant	0.93	isoniazid
mshA	575752	c.405G>C	synonymous_variant	0.92	ethionamide
mshA	575752	c.405G>C	synonymous_variant	0.92	isoniazid
mshA	575755	c.408G>A	synonymous_variant	0.92	ethionamide
mshA	575755	c.408G>A	synonymous_variant	0.92	isoniazid
mshA	575756	c.409C>T	synonymous_variant	0.92	ethionamide
mshA	575756	c.409C>T	synonymous_variant	0.92	isoniazid
mshA	575770	c.423G>A	synonymous_variant	0.92	ethionamide
mshA	575770	c.423G>A	synonymous_variant	0.92	isoniazid
mshA	575771	p.Val142Ser	missense_variant	0.92	ethionamide
mshA	575771	p.Val142Ser	missense_variant	0.92	isoniazid
mshA	575779	c.432A>G	synonymous_variant	0.92	ethionamide
mshA	575779	c.432A>G	synonymous_variant	0.92	isoniazid
mshA	575782	c.435G>C	synonymous_variant	0.92	ethionamide
mshA	575782	c.435G>C	synonymous_variant	0.92	isoniazid
mshA	575809	c.462C>T	synonymous_variant	0.92	ethionamide
mshA	575809	c.462C>T	synonymous_variant	0.92	isoniazid
mshA	575812	c.465C>T	synonymous_variant	0.93	ethionamide
mshA	575812	c.465C>T	synonymous_variant	0.93	isoniazid
mshA	575821	c.474G>C	synonymous_variant	0.92	ethionamide
mshA	575821	c.474G>C	synonymous_variant	0.92	isoniazid
mshA	575824	c.477T>G	synonymous_variant	0.92	ethionamide
mshA	575824	c.477T>G	synonymous_variant	0.92	isoniazid
mshA	575830	c.483C>G	synonymous_variant	1.0	ethionamide
mshA	575830	c.483C>G	synonymous_variant	1.0	isoniazid
mshA	575845	c.498C>T	synonymous_variant	1.0	ethionamide
mshA	575845	c.498C>T	synonymous_variant	1.0	isoniazid	Not assoc w R - Interim
ccsA	619507	c.-384A>G	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619570	c.-321G>C	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620245	c.355T>C	synonymous_variant	0.93	capreomycin
					amikacin
					kanamycin
ccsA	620249	p.Ser120Cys	missense_variant	0.93	capreomycin
					amikacin
					kanamycin
ccsA	620254	c.364_366delCTCinsTG	frameshift_variant&missense_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620268	c.378G>C	synonymous_variant	0.69	capreomycin
					amikacin
					kanamycin
ccsA	620274	c.384G>C	synonymous_variant	0.64	capreomycin
					amikacin
					kanamycin
ccsA	620283	c.393T>C	synonymous_variant	0.93	capreomycin
					amikacin
					kanamycin
ccsA	620284	c.394_396delGCGinsCC	frameshift_variant&missense_variant	0.93	capreomycin
					amikacin
					kanamycin
ccsA	620295	c.405G>C	synonymous_variant	0.91	capreomycin
					amikacin
					kanamycin
ccsA	620310	c.420C>T	synonymous_variant	0.46	capreomycin
					amikacin
					kanamycin
ccsA	620317	c.427_429delGTCinsCG	frameshift_variant&missense_variant	0.92	capreomycin
					amikacin
					kanamycin
ccsA	620340	c.450C>G	synonymous_variant	0.91	capreomycin
					amikacin
					kanamycin
Rv0565c	657734	c.-264T>C	upstream_gene_variant	1.0	ethionamide
hadA	732305	p.Ile126Val	missense_variant	0.82	isoniazid
hadA	732308	p.Val127Ile	missense_variant	0.82	isoniazid
hadA	732321	p.Glu131Ala	missense_variant	0.83	isoniazid
hadA	732329	p.Leu134Val	missense_variant	0.85	isoniazid	Uncertain significance
hadA	732337	c.408G>A	synonymous_variant	0.88	isoniazid
hadA	732378	c.450_452dupAGA	disruptive_inframe_insertion	0.94	isoniazid
hadA	732396	p.Gly156Ala	missense_variant	0.92	isoniazid
hadA	732398	p.Ala157Thr	missense_variant	0.92	isoniazid
nusG	734421	c.168A>G	synonymous_variant	1.0	rifampicin
nusG	734424	c.171G>A	synonymous_variant	1.0	rifampicin
nusG	734442	c.189G>A	synonymous_variant	1.0	rifampicin
nusG	734451	c.198G>C	synonymous_variant	1.0	rifampicin
nusG	734457	c.204C>G	synonymous_variant	1.0	rifampicin
nusG	734472	c.219T>C	synonymous_variant	1.0	rifampicin
nusG	734475	c.222T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
nusG	734499	c.246G>C	synonymous_variant	1.0	rifampicin
nusG	734596	c.343T>C	synonymous_variant	1.0	rifampicin
rpoB	760223	c.417T>C	synonymous_variant	0.9	rifampicin
rpoB	760235	c.429T>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	760283	c.477G>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	760298	c.492G>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	760307	c.501T>C	synonymous_variant	0.92	rifampicin
rpoB	760310	c.504G>C	synonymous_variant	0.83	rifampicin
rpoB	760328	c.522G>C	synonymous_variant	0.91	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	0.91	rifampicin
rpoB	760340	c.534G>T	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	760361	c.555T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	760370	c.564C>G	synonymous_variant	0.92	rifampicin
rpoB	760376	p.Asp190Glu	missense_variant	0.92	rifampicin	Uncertain significance
rpoB	760380	p.Thr192Leu	missense_variant	0.92	rifampicin
rpoB	760406	c.600G>C	synonymous_variant	0.93	rifampicin
rpoB	760412	c.606C>G	synonymous_variant	1.0	rifampicin
rpoB	760424	c.618C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760430	c.624T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760472	c.666C>T	synonymous_variant	0.73	rifampicin
rpoB	760475	c.669A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760481	c.675G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760484	c.678A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760522	p.Ser239Asn	missense_variant	1.0	rifampicin	Uncertain significance
rpoB	760532	c.726T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760533	p.Val243Thr	missense_variant	1.0	rifampicin
rpoB	760541	c.735G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760547	c.741G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760563	p.Arg253Met	missense_variant	1.0	rifampicin	Uncertain significance
rpoB	760591	p.Val262Ala	missense_variant	1.0	rifampicin
rpoB	760611	c.805T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760646	c.840C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760655	c.849A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760661	c.855A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760670	c.864G>C	synonymous_variant	1.0	rifampicin
rpoB	760674	c.868T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760679	c.873A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760683	c.877T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760715	c.909C>G	synonymous_variant	1.0	rifampicin
rpoB	760718	c.912C>T	synonymous_variant	1.0	rifampicin
rpoB	760724	c.918T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760793	c.987A>G	synonymous_variant	0.8	rifampicin
rpoB	760805	c.999G>C	synonymous_variant	0.8	rifampicin
rpoB	760826	c.1020C>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	760830	c.1024T>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	760841	c.1035T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	760845	p.Thr347Pro	missense_variant	0.83	rifampicin
rpoB	760869	p.Val355Ile	missense_variant	0.82	rifampicin	Uncertain significance
rpoB	760886	c.1080A>G	synonymous_variant	0.85	rifampicin
rpoB	760925	c.1119T>C	synonymous_variant	0.94	rifampicin
rpoB	760928	c.1122G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	760931	c.1125C>G	synonymous_variant	0.93	rifampicin
rpoB	760934	c.1128C>T	synonymous_variant	0.94	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	760982	c.1176G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	760985	c.1179G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	760991	c.1185G>C	synonymous_variant	0.93	rifampicin
rpoB	761006	c.1200C>G	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	761015	c.1209G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	761021	c.1215G>C	synonymous_variant	0.93	rifampicin
rpoB	761027	c.1221A>G	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	761057	c.1251G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	761087	c.1281C>T	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	761102	c.1296A>G	synonymous_variant	0.94	rifampicin
rpoB	761129	c.1323G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761132	c.1326G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761133	c.1327T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761150	c.1344A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761153	c.1347G>C	synonymous_variant	1.0	rifampicin
rpoB	761165	c.1359G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761180	c.1374A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761189	c.1383T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761195	c.1389G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761207	c.1401C>T	synonymous_variant	1.0	rifampicin
rpoB	761213	c.1407G>C	synonymous_variant	1.0	rifampicin
rpoB	761219	c.1413G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761249	c.1443A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761255	c.1449T>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761261	c.1455G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761306	c.1500C>G	synonymous_variant	1.0	rifampicin
rpoB	761537	c.1731C>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	761570	c.1764T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	761573	c.1767C>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	761579	c.1773G>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	761588	c.1782C>T	synonymous_variant	0.83	rifampicin
rpoB	761606	c.1800C>G	synonymous_variant	0.8	rifampicin
rpoB	761612	c.1806G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	761615	c.1809A>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	761747	c.1941G>C	synonymous_variant	0.9	rifampicin
rpoB	761750	c.1944G>C	synonymous_variant	0.9	rifampicin
rpoB	761765	c.1959T>C	synonymous_variant	0.9	rifampicin
rpoB	761948	c.2142G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761954	c.2148C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762008	c.2202C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762014	c.2208C>T	synonymous_variant	1.0	rifampicin
rpoB	762017	c.2211A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762053	c.2247T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762062	c.2256T>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	762065	c.2259T>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	762083	c.2277T>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	762101	c.2295C>G	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	0.86	rifampicin	Uncertain significance
rpoB	762131	c.2325C>G	synonymous_variant	0.85	rifampicin
rpoB	762140	c.2334G>C	synonymous_variant	0.83	rifampicin
rpoB	762143	c.2337T>C	synonymous_variant	0.79	rifampicin
rpoB	762149	c.2343G>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	762167	c.2361T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	762176	c.2370T>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	762206	c.2400C>G	synonymous_variant	0.76	rifampicin
rpoB	762233	c.2427G>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	762246	c.2440C>T	synonymous_variant	0.64	rifampicin
rpoB	762254	c.2448T>G	synonymous_variant	0.69	rifampicin
rpoB	762284	c.2478G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	762293	c.2487T>C	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	762317	c.2511A>G	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762329	c.2523G>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762338	c.2532T>C	synonymous_variant	0.56	rifampicin
rpoB	762347	c.2541T>C	synonymous_variant	0.59	rifampicin
rpoB	762449	c.2643C>A	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	762857	c.3051C>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	762860	c.3054G>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	762863	c.3057T>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	762989	c.-381G>C	upstream_gene_variant	0.95	rifampicin
rpoB	762995	c.3189G>T	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	763013	c.-357C>G	upstream_gene_variant	0.9	rifampicin
rpoB	763028	c.3222T>C	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoB	763031	c.3225T>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	763034	c.3228C>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	763040	c.3234C>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	763070	c.3264T>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	763085	c.3279C>G	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	763115	c.3309T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	763136	c.3330C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763148	c.-222G>C	upstream_gene_variant	0.8	rifampicin
rpoC	763158	c.-212C>T	upstream_gene_variant	0.8	rifampicin
rpoB	763166	c.3360A>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	763190	c.-180C>T	upstream_gene_variant	0.8	rifampicin
rpoC	763402	c.33C>G	synonymous_variant	0.79	rifampicin
rpoC	763411	c.42T>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	763414	c.45T>C	synonymous_variant	0.81	rifampicin
rpoC	763441	c.72C>T	synonymous_variant	0.88	rifampicin
rpoC	763444	c.75T>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	763456	c.87A>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	763486	c.117T>G	synonymous_variant	1.0	rifampicin
rpoC	763492	c.123G>A	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	763528	c.159G>A	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763546	c.177A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	763573	c.204G>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	763603	c.234C>T	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	763636	c.267T>C	synonymous_variant	0.82	rifampicin
rpoC	763657	c.288G>A	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	763660	c.291T>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	763675	c.306C>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	763696	c.327T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	763702	c.333C>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	763717	c.348T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	763723	c.354G>C	synonymous_variant	0.74	rifampicin
rpoC	763732	c.363C>G	synonymous_variant	0.75	rifampicin
rpoC	763738	c.369G>A	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	763741	c.372C>T	synonymous_variant	0.76	rifampicin
rpoC	763744	c.375G>C	synonymous_variant	0.81	rifampicin
rpoC	763765	c.396T>C	synonymous_variant	0.82	rifampicin
rpoC	763774	c.405G>C	synonymous_variant	0.83	rifampicin
rpoC	763807	c.438T>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	763816	c.447C>G	synonymous_variant	0.87	rifampicin
rpoC	763835	p.Ala156Met	missense_variant	0.91	rifampicin
rpoC	763853	p.Val162Ile	missense_variant	0.95	rifampicin
rpoC	763858	c.489A>G	synonymous_variant	1.0	rifampicin
rpoC	763872	p.Gly168Ala	missense_variant	1.0	rifampicin
rpoC	763876	p.Glu169Asp	missense_variant	1.0	rifampicin
rpoC	763879	c.510A>G	synonymous_variant	1.0	rifampicin
rpoC	763888	c.519G>C	synonymous_variant	1.0	rifampicin
rpoC	763891	c.522G>C	synonymous_variant	1.0	rifampicin
rpoC	763894	c.525A>G	synonymous_variant	1.0	rifampicin
rpoC	763900	c.531G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763945	c.576T>C	synonymous_variant	0.92	rifampicin
rpoC	763951	c.582G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	763960	c.591T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	763987	c.618C>T	synonymous_variant	0.85	rifampicin
rpoC	763991	c.622_624delATCinsCG	frameshift_variant&missense_variant	0.83	rifampicin
rpoC	763996	c.627T>C	synonymous_variant	0.82	rifampicin
rpoC	764002	c.633C>G	synonymous_variant	0.82	rifampicin
rpoC	764005	c.636G>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	764024	c.655_657delTTGinsCC	frameshift_variant&missense_variant	0.8	rifampicin
rpoC	764032	p.Asp221Glu	missense_variant	0.82	rifampicin
rpoC	764040	p.Ser224Thr	missense_variant	0.82	rifampicin
rpoC	764044	c.675T>C	synonymous_variant	0.82	rifampicin
rpoC	764059	c.690G>T	synonymous_variant	0.82	rifampicin
rpoC	764083	c.714A>G	synonymous_variant	0.83	rifampicin
rpoC	764098	c.729A>G	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	764101	c.732C>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764102	p.Val245Ile	missense_variant	0.9	rifampicin
rpoC	764112	p.Tyr248Phe	missense_variant	0.91	rifampicin
rpoC	764116	c.747C>T	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	764131	c.762T>C	synonymous_variant	0.91	rifampicin
rpoC	764188	c.819A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764195	p.Ser276Ile	missense_variant	1.0	rifampicin
rpoC	764203	c.834G>C	synonymous_variant	1.0	rifampicin
rpoC	764206	c.837T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764215	c.846A>G	synonymous_variant	1.0	rifampicin
rpoC	764236	c.867G>A	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764248	c.879C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764257	c.888G>C	synonymous_variant	1.0	rifampicin
rpoC	764266	c.897T>C	synonymous_variant	1.0	rifampicin
rpoC	764269	c.900G>C	synonymous_variant	1.0	rifampicin
rpoC	764272	c.903G>C	synonymous_variant	1.0	rifampicin
rpoC	764278	c.909A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764405	c.1036A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764428	c.1059G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764431	c.1062G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764434	c.1065A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764446	c.1077T>C	synonymous_variant	1.0	rifampicin
rpoC	764449	c.1080G>C	synonymous_variant	0.92	rifampicin
rpoC	764452	c.1083T>C	synonymous_variant	1.0	rifampicin
rpoC	764458	c.1089G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764461	c.1092A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764489	c.1120C>T	synonymous_variant	0.85	rifampicin
rpoC	764497	c.1128A>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764560	c.1191T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	764566	c.1197C>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764575	c.1206T>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764611	c.1242G>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	764752	c.1383G>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	764764	c.1395T>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	764809	c.1440C>T	synonymous_variant	0.95	rifampicin	Not assoc w R
rpoC	764815	c.1446A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764827	c.1458G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764858	c.1489T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764872	c.1503A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764888	c.1519T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764911	c.1542A>G	synonymous_variant	1.0	rifampicin
rpoC	764932	c.1563C>A	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	764968	c.1599T>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764995	c.1626C>G	synonymous_variant	0.93	rifampicin	Not assoc w R
rpoC	765007	c.1638T>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	765008	c.1639T>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	765011	c.1642_1643delAGinsTC	synonymous_variant	0.85	rifampicin
rpoC	765019	c.1650A>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	765034	c.1665T>C	synonymous_variant	0.86	rifampicin
rpoC	765040	c.1671T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	765041	c.1672T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	765047	c.1678T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	765055	c.1686C>G	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	765073	c.1704G>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	765076	c.1707A>G	synonymous_variant	0.85	rifampicin
rpoC	765079	c.1710T>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	765082	c.1713G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	765089	c.1720T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	765103	c.1734G>T	synonymous_variant	0.91	rifampicin
rpoC	765478	c.2109T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765499	c.2130C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765529	c.2160C>T	synonymous_variant	1.0	rifampicin
rpoC	765541	c.2172C>G	synonymous_variant	1.0	rifampicin
rpoC	765553	c.2184C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765556	c.2187G>C	synonymous_variant	1.0	rifampicin
rpoC	765559	c.2190G>C	synonymous_variant	1.0	rifampicin
rpoC	765580	c.2211G>C	synonymous_variant	1.0	rifampicin
rpoC	765613	p.His748Gln	missense_variant	1.0	rifampicin
rpoC	765625	c.2256C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765631	p.Asp754Glu	missense_variant	1.0	rifampicin
rpoC	765700	c.2331T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765772	c.2403C>G	synonymous_variant	1.0	rifampicin
rpoC	765784	c.2415C>G	synonymous_variant	1.0	rifampicin
rpoC	765787	c.2418C>T	synonymous_variant	1.0	rifampicin
rpoC	765793	c.2424C>G	synonymous_variant	1.0	rifampicin
rpoC	765796	c.2427C>T	synonymous_variant	1.0	rifampicin
rpoC	765811	c.2442T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765814	c.2445A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765826	c.2457T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765835	c.2466C>T	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	765850	c.2481G>C	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	765883	c.2514C>G	synonymous_variant	0.94	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	1.0	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765937	c.2568T>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	765947	c.2578T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765967	c.2598C>T	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	765982	c.2613C>G	synonymous_variant	0.93	rifampicin
rpoC	765994	c.2625A>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	766010	c.2641_2642delTCinsAG	synonymous_variant	0.92	rifampicin
rpoC	766021	c.2652G>C	synonymous_variant	0.93	rifampicin
rpoC	766027	c.2658G>C	synonymous_variant	0.94	rifampicin
rpoC	766043	p.Gln892Glu	missense_variant	0.94	rifampicin
rpoC	766054	c.2685C>G	synonymous_variant	1.0	rifampicin
rpoC	766082	p.Ala905Gln	missense_variant	1.0	rifampicin
rpoC	766096	c.2727G>C	synonymous_variant	1.0	rifampicin
rpoC	766129	c.2760C>G	synonymous_variant	1.0	rifampicin
rpoC	766135	c.2766G>A	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766142	c.2773C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766381	c.3012C>T	synonymous_variant	1.0	rifampicin
rpoC	766384	c.3015A>G	synonymous_variant	1.0	rifampicin
rpoC	766390	c.3021C>T	synonymous_variant	1.0	rifampicin
rpoC	766393	c.3024C>G	synonymous_variant	1.0	rifampicin
rpoC	766408	c.3039C>G	synonymous_variant	1.0	rifampicin
rpoC	766411	c.3042C>G	synonymous_variant	1.0	rifampicin
rpoC	766426	c.3057C>T	synonymous_variant	1.0	rifampicin
rpoC	766447	c.3078T>C	synonymous_variant	1.0	rifampicin
rpoC	766462	c.3093G>C	synonymous_variant	1.0	rifampicin
rpoC	766483	c.3114G>C	synonymous_variant	1.0	rifampicin
rpoC	766484	c.3115_3117delGTAinsAC	frameshift_variant&missense_variant	1.0	rifampicin
rpoC	766492	c.3123T>C	synonymous_variant	1.0	rifampicin
rpoC	766522	c.3153C>G	synonymous_variant	1.0	rifampicin
rpoC	766528	c.3159T>C	synonymous_variant	1.0	rifampicin
rpoC	766531	c.3162G>C	synonymous_variant	1.0	rifampicin
rpoC	766540	p.Asp1057Glu	missense_variant	1.0	rifampicin
rpoC	766549	c.3180G>C	synonymous_variant	1.0	rifampicin
rpoC	766573	c.3204T>C	synonymous_variant	1.0	rifampicin
rpoC	766582	c.3213C>G	synonymous_variant	1.0	rifampicin
rpoC	766583	c.3214_3216delGGTinsAC	frameshift_variant&missense_variant	1.0	rifampicin
rpoC	766591	c.3222A>G	synonymous_variant	1.0	rifampicin
rpoC	766594	c.3225G>C	synonymous_variant	1.0	rifampicin
rpoC	766597	c.3228C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766607	p.Ile1080Leu	missense_variant	1.0	rifampicin
rpoC	766630	c.3261G>C	synonymous_variant	1.0	rifampicin
rpoC	766657	c.3288A>G	synonymous_variant	1.0	rifampicin
rpoC	766672	c.3303T>C	synonymous_variant	1.0	rifampicin
rpoC	766673	p.Gly1102Asn	missense_variant	1.0	rifampicin
rpoC	766726	c.3357T>C	synonymous_variant	1.0	rifampicin
rpoC	766738	c.3369G>C	synonymous_variant	1.0	rifampicin
rpoC	766765	c.3396A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766774	c.3405T>C	synonymous_variant	1.0	rifampicin
rpoC	766801	c.3432C>G	synonymous_variant	1.0	rifampicin
rpoC	766804	c.3435A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766861	c.3492G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766864	c.3495G>C	synonymous_variant	1.0	rifampicin
rpoC	766900	c.3531T>C	synonymous_variant	1.0	rifampicin
rpoC	766933	c.3564A>G	synonymous_variant	1.0	rifampicin
rpoC	766945	c.3576A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766963	c.3594T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766972	c.3603G>C	synonymous_variant	0.93	rifampicin
rpoC	766996	c.3627C>T	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	767009	c.3640_3642delTCGinsAGC	synonymous_variant	0.83	rifampicin
rpoC	767014	c.3645G>C	synonymous_variant	0.83	rifampicin
rpoC	767059	c.3690T>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	767098	c.3729T>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	767119	c.3750A>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	767134	c.3765C>A	synonymous_variant	0.77	rifampicin
rpoC	767158	c.3789T>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	767180	p.Ala1271Gln	missense_variant	0.83	rifampicin
rpoC	767191	c.3822C>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpsL	781649	c.90T>C	synonymous_variant	0.91	streptomycin
rpsL	781655	c.96T>C	synonymous_variant	0.91	streptomycin
rpsL	781682	c.123T>C	synonymous_variant	0.54	streptomycin
rpsL	781700	c.141G>C	synonymous_variant	0.92	streptomycin
rpsL	781703	c.144G>T	synonymous_variant	0.93	streptomycin
rpsL	781715	c.156T>C	synonymous_variant	1.0	streptomycin
rpsL	781728	c.169T>C	synonymous_variant	1.0	streptomycin
rpsL	781736	c.177T>C	synonymous_variant	1.0	streptomycin
rpsL	781742	c.183C>T	synonymous_variant	1.0	streptomycin
rpsL	781748	c.189C>G	synonymous_variant	0.88	streptomycin
rpsL	781754	c.195G>C	synonymous_variant	1.0	streptomycin
rpsL	781760	c.201T>C	synonymous_variant	1.0	streptomycin
rpsL	781772	c.213C>A	synonymous_variant	0.89	streptomycin
rpsL	781808	c.249C>T	synonymous_variant	0.92	streptomycin
rpsL	781811	c.252C>T	synonymous_variant	0.92	streptomycin
rpsL	781832	c.273T>C	synonymous_variant	1.0	streptomycin
rpsL	781838	c.279G>C	synonymous_variant	0.9	streptomycin
rpsL	781841	c.282C>G	synonymous_variant	1.0	streptomycin
rpsL	781865	c.306G>C	synonymous_variant	0.8	streptomycin
rpsL	781868	c.309T>C	synonymous_variant	0.9	streptomycin
rpsL	781871	c.312G>C	synonymous_variant	0.9	streptomycin
rpsL	781877	c.318T>C	synonymous_variant	0.82	streptomycin
rpsL	781892	c.333A>G	synonymous_variant	0.9	streptomycin
rpsL	781898	c.339A>T	synonymous_variant	0.92	streptomycin
rpsL	781916	c.357T>C	synonymous_variant	0.92	streptomycin
rpsL	781929	p.Gly124Ser	missense_variant	0.93	streptomycin	Uncertain significance
rplC	801423	c.615G>C	synonymous_variant	1.0	linezolid
rplC	801426	c.618C>G	synonymous_variant	1.0	linezolid
rplC	801427	p.Met207Val	missense_variant	1.0	linezolid
rplC	801438	c.630T>C	synonymous_variant	1.0	linezolid
rplC	801442	p.Ile212Val	missense_variant	1.0	linezolid
fbiC	1303590	c.660A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303602	c.672A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303605	c.675C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303608	c.678G>A	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303614	c.684C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303617	c.687C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303632	c.702T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303641	c.711C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303671	c.741C>T	synonymous_variant	1.0	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fbiC	1303674	c.744C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303681	c.751T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303686	c.756C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303695	c.765T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303704	c.774T>C	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1303708	c.778T>C	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1303728	c.798G>A	synonymous_variant	0.9	clofazimine
					pretomanid
					delamanid
fbiC	1303731	c.801A>C	synonymous_variant	0.9	clofazimine
					pretomanid
					delamanid
fbiC	1303732	p.Ser268Ala	missense_variant	0.9	clofazimine
					pretomanid
					delamanid
fbiC	1303737	c.807G>A	synonymous_variant	0.9	clofazimine
					pretomanid
					delamanid
fbiC	1303746	c.816T>C	synonymous_variant	0.9	clofazimine
					pretomanid
					delamanid
fbiC	1303749	c.819G>C	synonymous_variant	0.9	clofazimine
					pretomanid
					delamanid
fbiC	1303752	c.822A>G	synonymous_variant	0.9	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1303755	c.825T>C	synonymous_variant	0.9	clofazimine
					pretomanid
					delamanid
fbiC	1303761	c.831T>C	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fbiC	1303785	c.855G>C	synonymous_variant	0.85	clofazimine
					pretomanid
					delamanid
fbiC	1303797	c.867A>G	synonymous_variant	0.83	clofazimine
					pretomanid
					delamanid
fbiC	1303818	c.888C>G	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1303836	c.906G>C	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1303845	c.915C>G	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1303846	p.Phe306Val	missense_variant	0.69	clofazimine
					pretomanid
					delamanid
fbiC	1303854	c.924T>C	synonymous_variant	0.79	clofazimine
					pretomanid
					delamanid
fbiC	1303860	c.930A>C	synonymous_variant	0.79	clofazimine
					pretomanid
					delamanid
fbiC	1303884	c.954T>G	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiC	1303905	c.975G>C	synonymous_variant	0.84	clofazimine
					pretomanid
					delamanid
fbiC	1303914	c.984C>G	synonymous_variant	0.79	clofazimine
					pretomanid
					delamanid
fbiC	1303920	c.990C>T	synonymous_variant	0.78	clofazimine
					pretomanid
					delamanid
fbiC	1303944	c.1014G>C	synonymous_variant	0.79	clofazimine
					pretomanid
					delamanid
fbiC	1303947	c.1017T>G	synonymous_variant	0.83	clofazimine
					pretomanid
					delamanid
fbiC	1303948	p.Gly340Arg	missense_variant	0.83	clofazimine
					pretomanid
					delamanid
fbiC	1303953	p.Asp341Glu	missense_variant	0.83	clofazimine
					pretomanid
					delamanid
fbiC	1303961	p.Arg344Leu	missense_variant	0.83	clofazimine
					pretomanid
					delamanid
fbiC	1303971	c.1041T>C	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1303980	c.1050G>A	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1304742	c.1812T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304748	c.1818T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304757	c.1827A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304778	c.1848T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304784	c.1854T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304787	c.1857T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304808	c.1878C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304811	c.1881C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304817	c.1887T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304829	c.1899T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304832	c.1902C>T	synonymous_variant	1.0	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304853	c.1923C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304856	c.1926C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304869	c.1939C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304875	p.Ile649Val	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304883	p.Glu651Asp	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304891	p.Ile654Thr	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304893	p.Gly655Ser	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304907	c.1977C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304910	c.1980G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304916	c.1986T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304928	c.1998T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304937	c.2007G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304958	c.2028T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304983	c.2053C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304994	c.2064A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304995	p.Leu689Met	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305006	c.2076A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305012	c.2082G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305015	c.2085G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305021	c.2091C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305030	c.2100G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305033	c.2103T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305042	c.2112A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305063	c.2133G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305066	c.2136T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305069	c.2139G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305252	c.2322G>A	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
rrs	1471970	n.125G>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.61	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472177	n.332C>T	non_coding_transcript_exon_variant	0.63	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472240	n.395G>C	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472242	n.397C>T	non_coding_transcript_exon_variant	0.5	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472251	n.406G>T	non_coding_transcript_exon_variant	0.38	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472252	n.407G>A	non_coding_transcript_exon_variant	0.36	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472253	n.408G>T	non_coding_transcript_exon_variant	0.36	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472256	n.411T>A	non_coding_transcript_exon_variant	0.36	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472259	n.414C>A	non_coding_transcript_exon_variant	0.35	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472374	n.529T>G	non_coding_transcript_exon_variant	0.35	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472382	n.537G>A	non_coding_transcript_exon_variant	0.35	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472389	n.544G>A	non_coding_transcript_exon_variant	0.35	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472517	n.672T>A	non_coding_transcript_exon_variant	0.65	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472537	n.692C>T	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472541	n.696T>G	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472545	n.700A>T	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472553	n.708C>T	non_coding_transcript_exon_variant	0.62	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>C	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472572	n.727T>C	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin
					amikacin	Uncertain significance
rrs	1472574	n.729T>C	non_coding_transcript_exon_variant	0.52	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472579	n.734_735delGCinsACGA	non_coding_transcript_exon_variant	0.54	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472582	n.738_739delTA	non_coding_transcript_exon_variant	0.54	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472594	n.749G>C	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472598	n.753A>T	non_coding_transcript_exon_variant	0.62	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.59	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472655	n.810G>A	non_coding_transcript_exon_variant	0.5	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472742	n.897C>T	non_coding_transcript_exon_variant	0.58	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472754	n.909G>T	non_coding_transcript_exon_variant	0.65	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472781	n.936C>T	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472793	n.948A>T	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472827	n.982G>T	non_coding_transcript_exon_variant	0.42	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472828	n.983T>C	non_coding_transcript_exon_variant	0.42	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472969	n.1124A>G	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472970	n.1125C>G	non_coding_transcript_exon_variant	0.93	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472977	n.1132G>C	non_coding_transcript_exon_variant	0.93	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472978	n.1133T>C	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473105	n.1260G>A	non_coding_transcript_exon_variant	0.92	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473123	n.1278delAinsTT	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473945	n.288T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473945	n.288T>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473946	n.289A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473946	n.289A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473987	n.330G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473987	n.330G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	linezolid	Not assoc w R
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474956	n.1299C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474956	n.1299C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474960	n.1303C>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474960	n.1303C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474963	n.1306G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474963	n.1306G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474964	n.1307T>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474964	n.1307T>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474965	n.1308G>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474965	n.1308G>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474970	n.1313G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474970	n.1313G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1475267	n.1610G>A	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1475267	n.1610G>A	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475436	n.1779C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475436	n.1779C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1475765	n.2111delG	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1475765	n.2111delG	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476214	n.2557G>A	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1476214	n.2557G>A	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476336	n.2679C>T	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1476336	n.2679C>T	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1476356	n.2699C>A	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1476356	n.2699C>A	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1476357	n.2700T>C	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1476357	n.2700T>C	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1476383	n.2726T>G	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476383	n.2726T>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476384	n.2727G>T	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1476384	n.2727G>T	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1476411	n.2754G>A	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1476411	n.2754G>A	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1476425	n.2768G>A	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476425	n.2768G>A	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.87	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1476442	n.2785T>A	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476442	n.2785T>A	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476443	n.2786G>T	non_coding_transcript_exon_variant	0.86	capreomycin
rrl	1476443	n.2786G>T	non_coding_transcript_exon_variant	0.86	linezolid
rrl	1476455	n.2798C>A	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1476455	n.2798C>A	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1476456	n.2799A>T	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476456	n.2799A>T	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476463	n.2806C>T	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1476463	n.2806C>T	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.87	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.55	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1476512	n.2855C>T	non_coding_transcript_exon_variant	0.43	capreomycin	Uncertain significance
rrl	1476512	n.2855C>T	non_coding_transcript_exon_variant	0.43	linezolid
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	1.0	linezolid
inhA	1673535	c.-667A>G	upstream_gene_variant	0.73	ethionamide
inhA	1673535	c.-667A>G	upstream_gene_variant	0.73	isoniazid
inhA	1674537	c.336C>G	synonymous_variant	0.9	ethionamide
inhA	1674537	c.336C>G	synonymous_variant	0.9	isoniazid
inhA	1674542	p.Ala114Glu	missense_variant	0.82	ethionamide
inhA	1674542	p.Ala114Glu	missense_variant	0.82	isoniazid
inhA	1674546	c.345T>C	synonymous_variant	0.82	ethionamide
inhA	1674546	c.345T>C	synonymous_variant	0.82	isoniazid
inhA	1674549	c.348G>C	synonymous_variant	0.83	ethionamide
inhA	1674549	c.348G>C	synonymous_variant	0.83	isoniazid
inhA	1674555	c.354G>A	synonymous_variant	0.83	ethionamide	Not assoc w R - Interim
inhA	1674555	c.354G>A	synonymous_variant	0.83	isoniazid	Not assoc w R - Interim
inhA	1674561	c.360C>T	synonymous_variant	0.83	ethionamide
inhA	1674561	c.360C>T	synonymous_variant	0.83	isoniazid
inhA	1674582	c.381T>C	synonymous_variant	0.86	ethionamide
inhA	1674582	c.381T>C	synonymous_variant	0.86	isoniazid
inhA	1674585	c.384T>C	synonymous_variant	0.86	ethionamide
inhA	1674585	c.384T>C	synonymous_variant	0.86	isoniazid
inhA	1674589	p.Met130Leu	missense_variant	0.87	ethionamide
inhA	1674589	p.Met130Leu	missense_variant	0.87	isoniazid
inhA	1674601	p.Leu134Thr	missense_variant	0.86	ethionamide
inhA	1674601	p.Leu134Thr	missense_variant	0.86	isoniazid
inhA	1674624	c.423A>C	synonymous_variant	0.92	ethionamide
inhA	1674624	c.423A>C	synonymous_variant	0.92	isoniazid
inhA	1674630	c.429C>G	synonymous_variant	0.92	ethionamide
inhA	1674630	c.429C>G	synonymous_variant	0.92	isoniazid
inhA	1674660	c.459G>C	synonymous_variant	0.92	ethionamide
inhA	1674660	c.459G>C	synonymous_variant	0.92	isoniazid
inhA	1674672	c.471C>G	synonymous_variant	0.9	ethionamide
inhA	1674672	c.471C>G	synonymous_variant	0.9	isoniazid
inhA	1674726	c.525G>A	synonymous_variant	1.0	ethionamide
inhA	1674726	c.525G>A	synonymous_variant	1.0	isoniazid
inhA	1674846	p.Ile215Met	missense_variant	0.91	ethionamide
inhA	1674846	p.Ile215Met	missense_variant	0.91	isoniazid
inhA	1674864	c.663C>T	synonymous_variant	0.82	ethionamide	Not assoc w R - Interim
inhA	1674864	c.663C>T	synonymous_variant	0.82	isoniazid	Not assoc w R - Interim
inhA	1674870	c.669T>C	synonymous_variant	0.8	ethionamide
inhA	1674870	c.669T>C	synonymous_variant	0.8	isoniazid
inhA	1674942	c.741T>G	synonymous_variant	0.83	ethionamide
inhA	1674942	c.741T>G	synonymous_variant	0.83	isoniazid
inhA	1674960	c.759C>G	synonymous_variant	0.8	ethionamide
inhA	1674960	c.759C>G	synonymous_variant	0.8	isoniazid
rpsA	1833595	c.54T>C	synonymous_variant	0.9	pyrazinamide
rpsA	1833661	c.120A>G	synonymous_variant	0.93	pyrazinamide
rpsA	1833667	c.126C>G	synonymous_variant	0.93	pyrazinamide
rpsA	1833721	c.180A>G	synonymous_variant	0.92	pyrazinamide
rpsA	1833724	c.183C>G	synonymous_variant	0.93	pyrazinamide
rpsA	1833727	c.186G>C	synonymous_variant	0.92	pyrazinamide
rpsA	1833742	c.201A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833748	c.207C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833787	c.246C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833790	c.249T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833802	c.261A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833811	c.270G>T	synonymous_variant	1.0	pyrazinamide
rpsA	1833838	c.297G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834099	c.558C>G	synonymous_variant	0.69	pyrazinamide
rpsA	1834102	c.561T>C	synonymous_variant	0.69	pyrazinamide
rpsA	1834105	c.564C>G	synonymous_variant	0.62	pyrazinamide
rpsA	1834108	c.567C>G	synonymous_variant	0.62	pyrazinamide
rpsA	1834123	c.582C>G	synonymous_variant	0.6	pyrazinamide
rpsA	1834150	c.609G>C	synonymous_variant	0.57	pyrazinamide
rpsA	1834153	c.612T>C	synonymous_variant	0.57	pyrazinamide
rpsA	1834154	c.613_615delAACinsCG	frameshift_variant&missense_variant	0.57	pyrazinamide	Uncertain significance
rpsA	1834157	c.616T>C	synonymous_variant	0.57	pyrazinamide
rpsA	1834162	c.621A>G	synonymous_variant	0.57	pyrazinamide	Not assoc w R - Interim
rpsA	1834165	c.624A>G	synonymous_variant	0.57	pyrazinamide
rpsA	1834169	p.Thr210Ala	missense_variant	0.57	pyrazinamide	Uncertain significance
rpsA	1834177	c.636A>C	synonymous_variant	0.87	pyrazinamide	Not assoc w R - Interim
rpsA	1834189	c.648G>C	synonymous_variant	0.6	pyrazinamide
rpsA	1834195	c.654G>C	synonymous_variant	0.62	pyrazinamide
rpsA	1834210	c.669C>T	synonymous_variant	0.62	pyrazinamide
rpsA	1834303	c.762T>C	synonymous_variant	0.9	pyrazinamide
rpsA	1834306	c.765T>C	synonymous_variant	0.91	pyrazinamide
rpsA	1834333	c.792C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834348	c.807T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
rpsA	1834366	c.825A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
rpsA	1834396	c.855G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834411	c.870T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834417	c.876G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834423	c.882G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834435	c.894G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834451	c.910T>C	synonymous_variant	0.93	pyrazinamide
rpsA	1834465	c.924T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834468	c.927A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834489	c.948T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834510	c.969C>T	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
rpsA	1834513	c.972C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834528	c.987T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834540	c.999G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834609	c.1068T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	1.0	pyrazinamide
tsnR	1853361	c.-245T>C	upstream_gene_variant	1.0	linezolid
tsnR	1853370	c.-236_-234delGCAinsTG	upstream_gene_variant	1.0	linezolid
tsnR	1853387	c.-219T>G	upstream_gene_variant	1.0	linezolid
tsnR	1853394	c.-212_-211delCTinsGC	upstream_gene_variant	1.0	linezolid
tsnR	1853420	c.-186T>G	upstream_gene_variant	1.0	linezolid
tsnR	1853426	c.-180G>A	upstream_gene_variant	0.71	linezolid
tsnR	1853429	c.-177G>C	upstream_gene_variant	1.0	linezolid
tsnR	1853432	c.-174G>C	upstream_gene_variant	1.0	linezolid
tlyA	1918002	c.63A>G	synonymous_variant	1.0	capreomycin
tlyA	1918036	p.Arg33Ser	missense_variant	1.0	capreomycin
tlyA	1918048	p.Leu37Met	missense_variant	1.0	capreomycin
bacA	2064948	c.-220G>C	upstream_gene_variant	0.9	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064972	c.-244T>C	upstream_gene_variant	0.92	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064978	c.-250G>C	upstream_gene_variant	0.93	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064979	c.-251C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064984	c.-256A>G	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064993	c.-265T>C	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
ndh	2101912	c.1131G>C	synonymous_variant	0.8	ethionamide
					delamanid
					isoniazid
ndh	2101920	c.1123A>C	synonymous_variant	0.8	ethionamide
					delamanid
					isoniazid
ndh	2101924	c.1119T>G	synonymous_variant	0.8	ethionamide
					delamanid
					isoniazid
kasA	2517950	c.-165C>G	upstream_gene_variant	1.0	isoniazid
kasA	2518528	c.414C>G	synonymous_variant	0.91	isoniazid
kasA	2518540	c.426T>C	synonymous_variant	0.92	isoniazid
kasA	2518609	p.Met165Ile	missense_variant	0.83	isoniazid
kasA	2518624	c.510C>G	synonymous_variant	0.85	isoniazid
kasA	2518639	c.525G>C	synonymous_variant	0.86	isoniazid
kasA	2518657	c.543G>C	synonymous_variant	0.92	isoniazid
kasA	2518672	c.558G>C	synonymous_variant	0.92	isoniazid
kasA	2518678	c.564C>T	synonymous_variant	0.92	isoniazid
kasA	2518684	c.570C>G	synonymous_variant	0.91	isoniazid
kasA	2518696	c.582C>G	synonymous_variant	0.92	isoniazid
kasA	2518702	c.588C>T	synonymous_variant	0.92	isoniazid
kasA	2518705	c.591T>C	synonymous_variant	0.92	isoniazid
kasA	2518711	c.597A>G	synonymous_variant	0.92	isoniazid
kasA	2518714	c.600A>C	synonymous_variant	0.93	isoniazid
kasA	2518732	c.618C>G	synonymous_variant	0.93	isoniazid
kasA	2518744	c.630C>T	synonymous_variant	1.0	isoniazid
kasA	2518747	c.633C>G	synonymous_variant	1.0	isoniazid
kasA	2518768	c.654C>T	synonymous_variant	1.0	isoniazid
kasA	2518777	c.663C>T	synonymous_variant	1.0	isoniazid
kasA	2518783	c.669T>C	synonymous_variant	1.0	isoniazid
kasA	2518789	c.675G>C	synonymous_variant	1.0	isoniazid
kasA	2518792	c.678C>A	synonymous_variant	1.0	isoniazid
kasA	2518795	c.681C>G	synonymous_variant	1.0	isoniazid
kasA	2518825	c.711T>C	synonymous_variant	0.94	isoniazid
kasA	2518864	c.750G>C	synonymous_variant	0.92	isoniazid
kasA	2518879	c.765A>G	synonymous_variant	0.93	isoniazid
kasA	2518885	c.771T>C	synonymous_variant	0.92	isoniazid
kasA	2518898	c.784T>C	synonymous_variant	0.92	isoniazid
kasA	2518906	c.792A>G	synonymous_variant	0.83	isoniazid
kasA	2518910	p.Leu266Met	missense_variant	0.75	isoniazid
kasA	2518921	c.807T>C	synonymous_variant	0.7	isoniazid
kasA	2518936	c.822C>G	synonymous_variant	0.73	isoniazid
kasA	2518939	c.825T>C	synonymous_variant	0.75	isoniazid
kasA	2518942	c.828T>C	synonymous_variant	0.75	isoniazid
kasA	2518951	c.837G>C	synonymous_variant	0.75	isoniazid
kasA	2518954	c.840C>G	synonymous_variant	0.75	isoniazid
kasA	2518963	c.849T>C	synonymous_variant	0.82	isoniazid
kasA	2518969	c.855T>G	synonymous_variant	0.8	isoniazid
kasA	2518975	c.861C>G	synonymous_variant	0.7	isoniazid
kasA	2518979	c.865A>C	synonymous_variant	0.7	isoniazid
kasA	2519050	c.936C>G	synonymous_variant	0.82	isoniazid
kasA	2519053	c.939G>C	synonymous_variant	0.82	isoniazid
kasA	2519056	c.942G>C	synonymous_variant	0.82	isoniazid
kasA	2519062	c.948T>G	synonymous_variant	0.92	isoniazid
kasA	2519068	c.954C>T	synonymous_variant	0.92	isoniazid
kasA	2519072	p.Ala320Thr	missense_variant	0.92	isoniazid
kasA	2519107	c.993T>C	synonymous_variant	0.9	isoniazid
kasA	2519108	c.994_996delGATinsCG	frameshift_variant&missense_variant	0.9	isoniazid
ahpC	2726564	c.372C>G	synonymous_variant	0.82	isoniazid	Not assoc w R - Interim
ahpC	2726591	c.399C>G	synonymous_variant	0.92	isoniazid
ahpC	2726593	p.Val134Ala	missense_variant	0.92	isoniazid
ahpC	2726600	c.408T>C	synonymous_variant	0.93	isoniazid
ahpC	2726601	p.Ile137Leu	missense_variant	0.93	isoniazid
ahpC	2726638	p.Ala149Val	missense_variant	1.0	isoniazid
ahpC	2726645	c.453C>G	synonymous_variant	1.0	isoniazid
ahpC	2726657	c.465A>C	synonymous_variant	1.0	isoniazid	Not assoc w R - Interim
Rv2477c	2782981	c.1062G>C	synonymous_variant	0.9	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782984	c.1059T>C	synonymous_variant	0.91	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782990	c.1053C>G	synonymous_variant	0.91	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783002	c.1041T>C	synonymous_variant	0.91	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783008	c.1035C>G	synonymous_variant	0.91	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783013	c.1030T>C	synonymous_variant	0.91	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783015	p.Ser343Thr	missense_variant	0.91	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783572	c.471A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783586	p.Ala153Pro	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783593	c.450T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783605	c.438T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783620	c.423C>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783628	p.Ala139Ser	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783650	c.393C>T	synonymous_variant	0.53	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783656	c.387G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783659	c.384A>G	synonymous_variant	0.53	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783665	c.378A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783674	c.369T>A	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783683	c.360A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783700	p.Thr115Ser	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783718	c.325T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783719	c.324A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783751	p.Ile98Val	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783758	p.Asp95Glu	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783761	c.282G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783766	p.Met93Leu	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783776	c.267G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783779	c.264T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783797	p.Asp82Glu	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783815	c.228A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783821	p.Gln74Leu	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783833	c.210G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783839	c.204C>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783843	p.Gly67Asp	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783846	p.Thr66Asn	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783860	c.183T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783863	c.180C>T	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783883	c.160T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783884	c.159T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783887	c.156C>G	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783914	c.129T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783920	c.123G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783929	c.114C>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783932	c.111C>T	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783938	c.105T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783953	c.90G>A	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783962	c.81T>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783971	c.72G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783980	c.63C>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2752c	3065007	c.1185G>C	synonymous_variant	0.8	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065013	c.1179G>C	synonymous_variant	0.8	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065018	p.Asn392His	missense_variant	0.8	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065022	c.1170G>A	synonymous_variant	0.9	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065028	c.1162_1164delGTGinsAC	frameshift_variant&missense_variant	0.92	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
Rv2752c	3065040	c.1152C>G	synonymous_variant	0.91	ethambutol	Not assoc w R - Interim
					moxifloxacin
					levofloxacin
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
Rv2752c	3065048	c.1144C>T	synonymous_variant	0.9	ethambutol	Not assoc w R - Interim
					moxifloxacin
					levofloxacin
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
thyX	3067325	c.621A>G	synonymous_variant	0.92	para-aminosalicylic_acid
thyX	3067349	c.597G>C	synonymous_variant	0.93	para-aminosalicylic_acid
thyX	3067355	c.591A>C	synonymous_variant	0.93	para-aminosalicylic_acid
thyX	3067367	c.579G>C	synonymous_variant	0.92	para-aminosalicylic_acid
thyX	3067373	c.573C>G	synonymous_variant	0.93	para-aminosalicylic_acid
thyX	3067439	c.507A>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067442	c.504C>T	synonymous_variant	0.69	para-aminosalicylic_acid
thyX	3067445	c.501C>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067457	c.489C>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067462	c.484C>T	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067465	p.Ile161Val	missense_variant	1.0	para-aminosalicylic_acid
thyX	3067466	c.480G>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067475	c.471A>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067510	c.436C>T	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067515	p.Ser144Thr	missense_variant	1.0	para-aminosalicylic_acid
thyX	3067530	p.Ala139Ser	missense_variant	1.0	para-aminosalicylic_acid
thyX	3067545	p.Glu134Ala	missense_variant	1.0	para-aminosalicylic_acid
thyX	3067549	p.Thr133Ala	missense_variant	1.0	para-aminosalicylic_acid
thyX	3067556	p.His130Gln	missense_variant	1.0	para-aminosalicylic_acid
thyX	3067652	c.294T>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067661	c.285C>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067685	c.261A>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067691	c.253_255delATCinsCG	frameshift_variant&missense_variant	1.0	para-aminosalicylic_acid
thyX	3067694	c.252G>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067718	c.228C>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067721	c.225T>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067727	c.219A>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067736	c.210C>T	synonymous_variant	1.0	para-aminosalicylic_acid
thyX	3067761	p.Arg62Lys	missense_variant	1.0	para-aminosalicylic_acid
thyX	3067765	p.Leu61Ile	missense_variant	0.92	para-aminosalicylic_acid
thyX	3067772	c.174C>G	synonymous_variant	0.54	para-aminosalicylic_acid
thyX	3067775	c.171C>T	synonymous_variant	0.57	para-aminosalicylic_acid
thyX	3067781	c.165C>G	synonymous_variant	0.93	para-aminosalicylic_acid
thyX	3067793	c.153T>C	synonymous_variant	0.93	para-aminosalicylic_acid
thyX	3067799	c.147G>A	synonymous_variant	0.92	para-aminosalicylic_acid
thyX	3067802	c.144C>G	synonymous_variant	0.92	para-aminosalicylic_acid
thyX	3067814	c.132T>C	synonymous_variant	0.93	para-aminosalicylic_acid
thyX	3067850	c.96A>C	synonymous_variant	0.9	para-aminosalicylic_acid
thyX	3067874	c.72C>G	synonymous_variant	0.8	para-aminosalicylic_acid
thyA	3074079	c.393G>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3074097	c.375C>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3074100	c.370_372delGATinsAC	frameshift_variant&synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3074106	c.366T>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3074360	c.112T>C	synonymous_variant	0.91	para-aminosalicylic_acid
thyA	3074361	c.111T>C	synonymous_variant	0.91	para-aminosalicylic_acid
thyA	3074372	p.Met34Leu	missense_variant	0.93	para-aminosalicylic_acid
thyA	3074377	p.Gln32Arg	missense_variant	0.93	para-aminosalicylic_acid
thyA	3074391	c.81C>A	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074423	p.Pro17Ala	missense_variant	0.8	para-aminosalicylic_acid
thyA	3074427	c.45T>A	synonymous_variant	0.8	para-aminosalicylic_acid
thyA	3074431	p.Thr14Glu	missense_variant	0.8	para-aminosalicylic_acid
thyA	3074433	p.Glu13Asp	missense_variant	0.8	para-aminosalicylic_acid
thyA	3074442	c.28_30delTTCinsCG	frameshift_variant&missense_variant	0.8	para-aminosalicylic_acid
thyA	3074445	c.27C>A	synonymous_variant	0.8	para-aminosalicylic_acid
thyA	3074448	c.24G>C	synonymous_variant	0.8	para-aminosalicylic_acid
lpqB	3625134	c.-224T>C	upstream_gene_variant	1.0	bedaquiline
lpqB	3625134	c.-224T>C	upstream_gene_variant	1.0	rifampicin
mtrB	3625135	c.1479A>G	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
mtrB	3625135	c.1479A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
lpqB	3625138	c.-228C>G	upstream_gene_variant	1.0	bedaquiline
lpqB	3625138	c.-228C>G	upstream_gene_variant	1.0	rifampicin
lpqB	3625141	c.-231T>C	upstream_gene_variant	1.0	bedaquiline
lpqB	3625141	c.-231T>C	upstream_gene_variant	1.0	rifampicin
mtrB	3625149	p.Val489Ile	missense_variant	0.93	bedaquiline
mtrB	3625149	p.Val489Ile	missense_variant	0.93	rifampicin
lpqB	3625161	c.-251T>C	upstream_gene_variant	0.92	bedaquiline
lpqB	3625161	c.-251T>C	upstream_gene_variant	0.92	rifampicin
mtrB	3625162	c.1452T>C	synonymous_variant	0.92	bedaquiline	Not assoc w R - Interim
mtrB	3625162	c.1452T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
lpqB	3625165	c.-255G>C	upstream_gene_variant	0.92	bedaquiline
lpqB	3625165	c.-255G>C	upstream_gene_variant	0.92	rifampicin
lpqB	3625186	c.-276T>C	upstream_gene_variant	0.9	bedaquiline
lpqB	3625186	c.-276T>C	upstream_gene_variant	0.9	rifampicin
mtrB	3625189	c.1425A>G	synonymous_variant	0.9	bedaquiline
mtrB	3625189	c.1425A>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
lpqB	3625195	c.-285A>G	upstream_gene_variant	0.9	bedaquiline
lpqB	3625195	c.-285A>G	upstream_gene_variant	0.9	rifampicin
lpqB	3625602	c.-692T>C	upstream_gene_variant	1.0	bedaquiline
lpqB	3625602	c.-692T>C	upstream_gene_variant	1.0	rifampicin
lpqB	3625612	c.-702G>C	upstream_gene_variant	1.0	bedaquiline
lpqB	3625612	c.-702G>C	upstream_gene_variant	1.0	rifampicin
mtrB	3625616	p.Arg333Ala	missense_variant	1.0	bedaquiline
mtrB	3625616	p.Arg333Ala	missense_variant	1.0	rifampicin
lpqB	3625624	c.-714C>G	upstream_gene_variant	1.0	bedaquiline
lpqB	3625624	c.-714C>G	upstream_gene_variant	1.0	rifampicin
mtrB	3625636	c.978C>G	synonymous_variant	1.0	bedaquiline
mtrB	3625636	c.978C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3625656	c.958T>C	synonymous_variant	0.95	bedaquiline	Not assoc w R - Interim
mtrB	3625656	c.958T>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.95	bedaquiline
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.95	rifampicin
lpqB	3625669	c.-759G>C	upstream_gene_variant	0.9	bedaquiline
lpqB	3625669	c.-759G>C	upstream_gene_variant	0.9	rifampicin
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.95	bedaquiline
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.95	rifampicin
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.96	bedaquiline
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.96	rifampicin
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.42	bedaquiline
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.42	rifampicin
mtrB	3625705	c.909C>G	synonymous_variant	0.96	bedaquiline
mtrB	3625705	c.909C>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
mtrB	3625711	c.903C>T	synonymous_variant	0.96	bedaquiline
mtrB	3625711	c.903C>T	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
lpqB	3625714	c.-804C>T	upstream_gene_variant	0.96	bedaquiline
lpqB	3625714	c.-804C>T	upstream_gene_variant	0.96	rifampicin
mtrB	3625720	c.894G>C	synonymous_variant	0.96	bedaquiline
mtrB	3625720	c.894G>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
mtrB	3625729	c.885A>G	synonymous_variant	0.96	bedaquiline
mtrB	3625729	c.885A>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
lpqB	3625735	c.-825C>T	upstream_gene_variant	0.96	bedaquiline
lpqB	3625735	c.-825C>T	upstream_gene_variant	0.96	rifampicin
lpqB	3625749	c.-839C>T	upstream_gene_variant	0.96	bedaquiline
lpqB	3625749	c.-839C>T	upstream_gene_variant	0.96	rifampicin
mtrB	3625750	c.864G>A	synonymous_variant	0.42	bedaquiline
mtrB	3625750	c.864G>A	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
mtrB	3625755	p.Ala287Thr	missense_variant	0.96	bedaquiline
mtrB	3625755	p.Ala287Thr	missense_variant	0.96	rifampicin	Uncertain significance
mtrB	3625765	c.849C>G	synonymous_variant	0.96	bedaquiline
mtrB	3625765	c.849C>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
mtrB	3625774	c.840G>A	synonymous_variant	0.96	bedaquiline
mtrB	3625774	c.840G>A	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
lpqB	3625792	c.-882G>A	upstream_gene_variant	0.39	bedaquiline
lpqB	3625792	c.-882G>A	upstream_gene_variant	0.39	rifampicin
mtrB	3625797	p.Val273Met	missense_variant	0.96	bedaquiline	Uncertain significance
mtrB	3625797	p.Val273Met	missense_variant	0.96	rifampicin	Uncertain significance
mtrB	3625806	c.808A>C	synonymous_variant	0.95	bedaquiline
mtrB	3625806	c.808A>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
mtrB	3625807	c.807C>G	synonymous_variant	0.95	bedaquiline
mtrB	3625807	c.807C>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
mtrB	3625837	c.777C>G	synonymous_variant	0.94	bedaquiline
mtrB	3625837	c.777C>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
lpqB	3625843	c.-933C>G	upstream_gene_variant	0.47	bedaquiline
lpqB	3625843	c.-933C>G	upstream_gene_variant	0.47	rifampicin
lpqB	3625849	c.-939T>C	upstream_gene_variant	0.92	bedaquiline
lpqB	3625849	c.-939T>C	upstream_gene_variant	0.92	rifampicin
mtrB	3625852	c.762A>G	synonymous_variant	0.92	bedaquiline
mtrB	3625852	c.762A>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
lpqB	3625864	c.-954T>G	upstream_gene_variant	0.91	bedaquiline
lpqB	3625864	c.-954T>G	upstream_gene_variant	0.91	rifampicin
mtrB	3625876	c.738G>C	synonymous_variant	0.9	bedaquiline
mtrB	3625876	c.738G>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
mtrA	3626804	c.546A>G	synonymous_variant	1.0	bedaquiline
mtrA	3626804	c.546A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3626840	c.-227C>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3626840	c.-227C>G	upstream_gene_variant	1.0	rifampicin
mtrA	3626846	c.504G>A	synonymous_variant	1.0	bedaquiline
mtrA	3626846	c.504G>A	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3626858	c.-245A>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3626858	c.-245A>G	upstream_gene_variant	1.0	rifampicin
mtrB	3626861	c.-248C>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3626861	c.-248C>G	upstream_gene_variant	1.0	rifampicin
mtrB	3626866	c.-253T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3626866	c.-253T>C	upstream_gene_variant	1.0	rifampicin
mtrA	3626869	c.481C>T	synonymous_variant	1.0	bedaquiline
mtrA	3626869	c.481C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3626876	c.-263A>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3626876	c.-263A>G	upstream_gene_variant	1.0	rifampicin
mtrB	3626885	c.-272A>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3626885	c.-272A>C	upstream_gene_variant	1.0	rifampicin
mtrB	3626890	c.-277T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3626890	c.-277T>C	upstream_gene_variant	1.0	rifampicin
mtrB	3626903	c.-290T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3626903	c.-290T>C	upstream_gene_variant	1.0	rifampicin
mtrB	3626912	c.-299T>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3626912	c.-299T>G	upstream_gene_variant	1.0	rifampicin
mtrB	3626927	c.-314G>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3626927	c.-314G>C	upstream_gene_variant	1.0	rifampicin
mtrB	3626930	c.-317A>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3626930	c.-317A>G	upstream_gene_variant	1.0	rifampicin
mtrA	3626939	c.411A>G	synonymous_variant	1.0	bedaquiline
mtrA	3626939	c.411A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3626942	c.-329A>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3626942	c.-329A>C	upstream_gene_variant	1.0	rifampicin
mtrB	3626945	c.-332C>T	upstream_gene_variant	1.0	bedaquiline
mtrB	3626945	c.-332C>T	upstream_gene_variant	1.0	rifampicin
mtrB	3626957	c.-344G>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3626957	c.-344G>C	upstream_gene_variant	1.0	rifampicin
mtrB	3626972	c.-359A>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3626972	c.-359A>G	upstream_gene_variant	1.0	rifampicin
mtrB	3626987	c.-374C>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3626987	c.-374C>G	upstream_gene_variant	1.0	rifampicin
mtrB	3627008	c.-395G>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627008	c.-395G>C	upstream_gene_variant	1.0	rifampicin
mtrB	3627011	c.-398T>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3627011	c.-398T>G	upstream_gene_variant	1.0	rifampicin
mtrA	3627098	c.252A>C	synonymous_variant	1.0	bedaquiline
mtrA	3627098	c.252A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3627188	c.162A>G	synonymous_variant	1.0	bedaquiline
mtrA	3627188	c.162A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3627209	c.-596G>A	upstream_gene_variant	1.0	bedaquiline
mtrB	3627209	c.-596G>A	upstream_gene_variant	1.0	rifampicin
mtrA	3627221	c.129C>T	synonymous_variant	1.0	bedaquiline
mtrA	3627221	c.129C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3627227	c.123T>C	synonymous_variant	1.0	bedaquiline
mtrA	3627227	c.123T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3627233	c.-620T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627233	c.-620T>C	upstream_gene_variant	1.0	rifampicin
mtrB	3627236	c.-623T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627236	c.-623T>C	upstream_gene_variant	1.0	rifampicin
mtrA	3627242	c.108C>T	synonymous_variant	1.0	bedaquiline
mtrA	3627242	c.108C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3627254	c.-641C>T	upstream_gene_variant	1.0	bedaquiline
mtrB	3627254	c.-641C>T	upstream_gene_variant	1.0	rifampicin
fbiB	3642581	c.1047A>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiB	3642587	p.Met351Ile	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiB	3642593	c.1059G>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiB	3642602	c.1068A>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiB	3642605	c.1071A>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiB	3642609	c.1075_1076delAGinsTC	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiB	3642614	c.1080C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiB	3642617	c.1083C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiB	3642620	c.1086T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiB	3642656	c.1122G>C	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fbiB	3642659	c.1125C>G	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fbiB	3642668	c.1134A>G	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiB	3642677	c.1143A>G	synonymous_variant	0.83	clofazimine
					pretomanid
					delamanid
fbiB	3642680	c.1146A>G	synonymous_variant	0.83	clofazimine
					pretomanid
					delamanid
fbiB	3642684	c.1150T>C	synonymous_variant	0.83	clofazimine
					pretomanid
					delamanid
fbiB	3642701	c.1167C>G	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiB	3642719	c.1185T>C	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
rpoA	3877571	p.Pro313Ala	missense_variant	1.0	rifampicin
rpoA	3877587	c.921A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877613	p.Ile299Val	missense_variant	0.94	rifampicin
rpoA	3877656	c.852T>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoA	3877668	c.840A>G	synonymous_variant	0.95	rifampicin
rpoA	3877679	p.Ala277Ser	missense_variant	0.95	rifampicin
rpoA	3877686	c.822A>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoA	3877692	c.816G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoA	3877701	c.807G>A	synonymous_variant	0.35	rifampicin
rpoA	3877704	c.804G>C	synonymous_variant	0.94	rifampicin
rpoA	3877737	c.771G>C	synonymous_variant	0.88	rifampicin
rpoA	3877743	c.765T>C	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoA	3877791	c.717C>G	synonymous_variant	0.92	rifampicin
rpoA	3878187	c.321C>G	synonymous_variant	1.0	rifampicin
rpoA	3878193	c.315T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878199	c.309T>C	synonymous_variant	1.0	rifampicin
rpoA	3878217	c.291A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878226	c.282C>G	synonymous_variant	1.0	rifampicin
rpoA	3878232	c.276G>C	synonymous_variant	1.0	rifampicin
rpoA	3878247	c.261G>C	synonymous_variant	1.0	rifampicin
rpoA	3878271	c.237T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878284	p.Glu75Ala	missense_variant	1.0	rifampicin
rpoA	3878292	c.216T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878298	c.210A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878304	c.204G>T	synonymous_variant	1.0	rifampicin
rpoA	3878313	c.195G>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoA	3878322	c.186A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878331	c.177A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878334	c.174T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878337	c.171T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878346	c.162T>C	synonymous_variant	1.0	rifampicin
rpoA	3878364	c.144A>C	synonymous_variant	1.0	rifampicin
rpoA	3878367	c.141C>G	synonymous_variant	1.0	rifampicin
rpoA	3878376	c.132G>C	synonymous_variant	0.96	rifampicin
rpoA	3878385	c.123C>G	synonymous_variant	0.95	rifampicin
rpoA	3878388	c.120C>G	synonymous_variant	0.95	rifampicin
rpoA	3878391	c.117T>C	synonymous_variant	0.95	rifampicin
rpoA	3878415	c.93C>T	synonymous_variant	0.94	rifampicin
rpoA	3878424	c.84G>C	synonymous_variant	0.94	rifampicin
rpoA	3878436	c.72A>G	synonymous_variant	0.94	rifampicin
rpoA	3878442	c.66G>C	synonymous_variant	0.94	rifampicin
rpoA	3878454	c.54A>C	synonymous_variant	0.92	rifampicin
rpoA	3878472	p.Asp12Glu	missense_variant	0.91	rifampicin
rpoA	3878478	c.30C>G	synonymous_variant	0.9	rifampicin
rpoA	3878785	c.-278T>G	upstream_gene_variant	1.0	rifampicin
rpoA	3878788	c.-281G>C	upstream_gene_variant	1.0	rifampicin	Uncertain significance
rpoA	3878806	c.-299C>G	upstream_gene_variant	1.0	rifampicin
rpoA	3878809	c.-302T>C	upstream_gene_variant	1.0	rifampicin
rpoA	3878824	c.-317G>C	upstream_gene_variant	1.0	rifampicin
rpoA	3878833	c.-326C>G	upstream_gene_variant	1.0	rifampicin
rpoA	3878836	c.-331_-329delAAGinsTCC	upstream_gene_variant	1.0	rifampicin
rpoA	3878853	c.-346G>A	upstream_gene_variant	1.0	rifampicin
rpoA	3878878	c.-371T>C	upstream_gene_variant	0.93	rifampicin	Uncertain significance
rpoA	3878893	c.-386C>T	upstream_gene_variant	0.56	rifampicin
rpoA	3878909	c.-402A>G	upstream_gene_variant	0.93	rifampicin
rpoA	3878914	c.-407T>C	upstream_gene_variant	0.93	rifampicin	Uncertain significance
rpoA	3878917	c.-410G>A	upstream_gene_variant	0.93	rifampicin	Uncertain significance
rpoA	3878986	c.-479G>C	upstream_gene_variant	1.0	rifampicin
rpoA	3878998	c.-491C>G	upstream_gene_variant	1.0	rifampicin	Uncertain significance
rpoA	3879005	c.-499_-498delAAinsCG	upstream_gene_variant	1.0	rifampicin
rpoA	3879013	c.-506A>G	upstream_gene_variant	1.0	rifampicin
rpoA	3879079	c.-572A>G	upstream_gene_variant	0.95	rifampicin
rpoA	3879082	c.-575C>T	upstream_gene_variant	0.3	rifampicin
rpoA	3879088	c.-581A>C	upstream_gene_variant	0.95	rifampicin
rpoA	3879094	c.-587T>C	upstream_gene_variant	0.95	rifampicin
rpoA	3879121	c.-614T>G	upstream_gene_variant	1.0	rifampicin
rpoA	3879127	c.-620T>C	upstream_gene_variant	1.0	rifampicin
rpoA	3879154	c.-647T>C	upstream_gene_variant	1.0	rifampicin
rpoA	3879160	c.-653A>G	upstream_gene_variant	1.0	rifampicin
rpoA	3879178	c.-671T>C	upstream_gene_variant	1.0	rifampicin
clpC1	4038433	c.2272C>T	synonymous_variant	0.91	pyrazinamide
clpC1	4038434	c.2271G>A	synonymous_variant	0.91	pyrazinamide
clpC1	4038456	p.Val750Glu	missense_variant	0.92	pyrazinamide
clpC1	4038460	p.Leu749Met	missense_variant	0.92	pyrazinamide
clpC1	4038486	p.Gly740Asn	missense_variant	0.85	pyrazinamide
clpC1	4038489	p.Ala739Gly	missense_variant	0.85	pyrazinamide
clpC1	4038494	c.2211G>C	synonymous_variant	0.85	pyrazinamide
clpC1	4038497	p.Ser736Gln	missense_variant	0.85	pyrazinamide
clpC1	4038509	c.2196C>T	synonymous_variant	0.86	pyrazinamide
clpC1	4038596	c.2109A>G	synonymous_variant	0.92	pyrazinamide
clpC1	4038623	c.2082A>G	synonymous_variant	0.92	pyrazinamide
clpC1	4038640	p.Asp689Asn	missense_variant	1.0	pyrazinamide
clpC1	4038653	c.2052C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038658	p.Lys683Gln	missense_variant	1.0	pyrazinamide
clpC1	4038661	p.Ser682Thr	missense_variant	1.0	pyrazinamide
clpC1	4038662	c.2043T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038671	c.2034T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038683	c.2022T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4038695	c.2010C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4038701	c.2004G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038704	c.2001T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038707	c.1998C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4038710	c.1995G>C	synonymous_variant	0.93	pyrazinamide
clpC1	4038713	c.1992T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038755	c.1950G>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038770	c.1935C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038773	c.1932T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038782	c.1923G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038812	c.1893T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038845	c.1860G>C	synonymous_variant	0.92	pyrazinamide
clpC1	4038860	c.1845G>C	synonymous_variant	0.92	pyrazinamide	Not assoc w R - Interim
clpC1	4038878	c.1827A>G	synonymous_variant	0.92	pyrazinamide	Not assoc w R - Interim
clpC1	4038893	c.1812C>T	synonymous_variant	0.57	pyrazinamide
clpC1	4038908	c.1797C>G	synonymous_variant	0.92	pyrazinamide
clpC1	4038914	c.1791G>C	synonymous_variant	0.92	pyrazinamide
clpC1	4038923	c.1780_1782delCTAinsTG	frameshift_variant&synonymous_variant	1.0	pyrazinamide
clpC1	4038997	c.1708T>C	synonymous_variant	0.92	pyrazinamide	Not assoc w R - Interim
clpC1	4039004	c.1701C>G	synonymous_variant	0.91	pyrazinamide
clpC1	4039022	c.1683A>G	synonymous_variant	0.93	pyrazinamide
clpC1	4039064	c.1641C>T	synonymous_variant	0.93	pyrazinamide
clpC1	4039097	c.1608G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039103	c.1602T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039106	c.1599G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039112	c.1593C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039121	c.1584T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039142	c.1563A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039145	c.1560G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039169	p.Glu512Asp	missense_variant	1.0	pyrazinamide
clpC1	4039172	c.1533A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039178	c.1527G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039183	c.1522T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039186	c.1519C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4039226	c.1479T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4039274	c.1431G>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4039280	c.1425G>T	synonymous_variant	0.67	pyrazinamide	Not assoc w R - Interim
clpC1	4039286	c.1419T>C	synonymous_variant	0.94	pyrazinamide
clpC1	4039295	c.1410A>C	synonymous_variant	0.94	pyrazinamide
clpC1	4039298	c.1407T>C	synonymous_variant	0.94	pyrazinamide
clpC1	4039319	c.1386T>C	synonymous_variant	0.92	pyrazinamide	Not assoc w R - Interim
clpC1	4039322	c.1383T>C	synonymous_variant	0.92	pyrazinamide
clpC1	4039328	c.1377A>C	synonymous_variant	0.91	pyrazinamide
clpC1	4039331	c.1374C>G	synonymous_variant	0.91	pyrazinamide
clpC1	4039337	p.Thr456Gln	missense_variant	0.9	pyrazinamide
clpC1	4039349	c.1356C>T	synonymous_variant	0.9	pyrazinamide
clpC1	4039352	c.1353C>G	synonymous_variant	0.9	pyrazinamide
clpC1	4039364	c.1341C>G	synonymous_variant	0.92	pyrazinamide
clpC1	4039391	c.1314T>G	synonymous_variant	0.85	pyrazinamide
clpC1	4039409	c.1296T>C	synonymous_variant	0.85	pyrazinamide
clpC1	4039412	c.1293T>G	synonymous_variant	0.85	pyrazinamide
clpC1	4039415	p.Glu430Asp	missense_variant	0.85	pyrazinamide	Uncertain significance
clpC1	4039430	c.1275T>C	synonymous_variant	0.9	pyrazinamide
clpC1	4039484	c.1221T>C	synonymous_variant	0.9	pyrazinamide
clpC1	4039556	c.1149G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039559	c.1146C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039562	c.1143C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039565	c.1140G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039570	p.Met379Leu	missense_variant	1.0	pyrazinamide	Uncertain significance
clpC1	4039576	p.Ala377Pro	missense_variant	1.0	pyrazinamide
clpC1	4039577	c.1128T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4039589	c.1116G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039610	c.1095G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039616	c.1089G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039661	c.1044T>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039664	c.1041G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039694	c.1011G>C	synonymous_variant	0.93	pyrazinamide
clpC1	4039724	c.981A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039751	c.954A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039757	c.948A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039760	c.945T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039766	c.939T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039769	c.936C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039775	c.930G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039778	c.927A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039781	c.924G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039790	c.915C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039952	c.753T>C	synonymous_variant	0.83	pyrazinamide
clpC1	4039988	c.717C>G	synonymous_variant	0.86	pyrazinamide
clpC1	4039991	c.714G>C	synonymous_variant	0.86	pyrazinamide
clpC1	4040021	c.684A>C	synonymous_variant	0.92	pyrazinamide	Not assoc w R - Interim
clpC1	4040024	c.681A>G	synonymous_variant	0.92	pyrazinamide
clpC1	4040033	c.672G>C	synonymous_variant	0.92	pyrazinamide
clpC1	4040036	c.669C>G	synonymous_variant	0.92	pyrazinamide
clpC1	4040237	c.468C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4040246	c.459C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040249	c.456A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040267	c.438A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040273	c.432T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040279	c.426C>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040291	c.414G>C	synonymous_variant	0.93	pyrazinamide
clpC1	4040318	c.387C>G	synonymous_variant	0.93	pyrazinamide
clpC1	4040330	c.375C>G	synonymous_variant	0.91	pyrazinamide
clpC1	4040363	c.342A>T	synonymous_variant	0.82	pyrazinamide
clpC1	4040369	c.336C>G	synonymous_variant	0.82	pyrazinamide
clpC1	4040411	c.294T>C	synonymous_variant	0.82	pyrazinamide	Not assoc w R - Interim
clpC1	4040423	c.282A>G	synonymous_variant	0.83	pyrazinamide	Not assoc w R - Interim
clpC1	4040426	c.279T>C	synonymous_variant	0.8	pyrazinamide
panD	4044917	c.-636G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044926	c.-645C>A	upstream_gene_variant	1.0	pyrazinamide
panD	4044929	c.-648G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044935	c.-655_-654delAAinsTG	upstream_gene_variant	1.0	pyrazinamide
panD	4044941	c.-660G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044954	c.-674_-673delCCinsAT	upstream_gene_variant	1.0	pyrazinamide
panD	4044980	c.-699A>G	upstream_gene_variant	1.0	pyrazinamide
panD	4044983	c.-702G>T	upstream_gene_variant	1.0	pyrazinamide
panD	4044989	c.-708T>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045000	c.-719A>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045001	c.-720G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045019	c.-738G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045022	c.-741C>G	upstream_gene_variant	1.0	pyrazinamide
panD	4045028	c.-747C>G	upstream_gene_variant	1.0	pyrazinamide
panD	4045034	c.-753A>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045055	c.-774T>G	upstream_gene_variant	1.0	pyrazinamide
panD	4045067	c.-786C>G	upstream_gene_variant	1.0	pyrazinamide
panD	4045070	c.-789C>T	upstream_gene_variant	1.0	pyrazinamide
panD	4045076	c.-795A>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045088	c.-807T>C	upstream_gene_variant	1.0	pyrazinamide
glpK	4138654	c.1102C>T	synonymous_variant	0.79	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138670	c.1086G>C	synonymous_variant	0.85	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138679	c.1075_1077delATGinsGC	frameshift_variant&missense_variant	0.83	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
glpK	4138695	p.Pro354Asp	missense_variant	0.91	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138718	c.1038T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138721	c.1035G>A	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138724	c.1032A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138730	c.1026C>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138757	c.999A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138763	c.993G>A	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138769	c.987G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
embC	4240726	c.864G>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embC	4240780	c.918T>C	synonymous_variant	1.0	ethambutol
embC	4240783	c.921G>C	synonymous_variant	1.0	ethambutol
embC	4240789	c.927T>C	synonymous_variant	1.0	ethambutol
embC	4241107	c.1245G>C	synonymous_variant	0.82	ethambutol
embC	4241140	c.1278A>G	synonymous_variant	0.9	ethambutol	Not assoc w R - Interim
embC	4241146	c.1284C>G	synonymous_variant	0.9	ethambutol
embC	4241518	c.1656A>G	synonymous_variant	0.9	ethambutol
embC	4241521	c.1659T>C	synonymous_variant	0.9	ethambutol	Not assoc w R - Interim
embC	4241530	c.1668C>G	synonymous_variant	1.0	ethambutol
embC	4241536	c.1674A>G	synonymous_variant	1.0	ethambutol
embC	4241539	c.1677T>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embC	4241545	c.1683T>C	synonymous_variant	1.0	ethambutol
embC	4241548	c.1686T>C	synonymous_variant	1.0	ethambutol
embC	4241551	c.1689A>G	synonymous_variant	1.0	ethambutol
embC	4241567	p.Ile569Val	missense_variant	1.0	ethambutol
embC	4242791	c.2929_2931delGCAinsTC	frameshift_variant&missense_variant	0.9	ethambutol
embA	4242796	c.-437G>C	upstream_gene_variant	0.9	ethambutol
embA	4242799	c.-434T>C	upstream_gene_variant	0.9	ethambutol
embA	4242802	c.-431G>C	upstream_gene_variant	0.91	ethambutol
embA	4242820	c.-413G>C	upstream_gene_variant	0.92	ethambutol
embA	4242823	c.-410G>C	upstream_gene_variant	0.92	ethambutol
embA	4242832	c.-401A>C	upstream_gene_variant	0.92	ethambutol
embA	4242838	c.-395C>G	upstream_gene_variant	0.92	ethambutol
embC	4242841	c.2979C>T	synonymous_variant	0.92	ethambutol	Not assoc w R - Interim
embA	4242844	c.-389A>G	upstream_gene_variant	0.92	ethambutol
embA	4242847	c.-386C>A	upstream_gene_variant	0.92	ethambutol
embA	4242859	c.-374C>T	upstream_gene_variant	0.92	ethambutol
embA	4242862	c.-371A>G	upstream_gene_variant	1.0	ethambutol
embC	4242863	p.Tyr1001Asn	missense_variant	1.0	ethambutol
embC	4242883	c.3021C>G	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embA	4242892	c.-341G>C	upstream_gene_variant	1.0	ethambutol
embA	4242901	c.-332G>C	upstream_gene_variant	1.0	ethambutol
embA	4245089	c.1857G>C	synonymous_variant	0.9	ethambutol
embA	4245101	c.1869G>C	synonymous_variant	0.91	ethambutol
embA	4245137	c.1905T>C	synonymous_variant	1.0	ethambutol
embA	4245146	c.1914G>A	synonymous_variant	1.0	ethambutol
embA	4245149	c.1917C>G	synonymous_variant	1.0	ethambutol
embA	4245153	p.Ile641Val	missense_variant	1.0	ethambutol
embA	4245182	c.1950T>C	synonymous_variant	1.0	ethambutol
embA	4245189	c.1957C>T	synonymous_variant	1.0	ethambutol
embA	4245198	p.Leu656Ile	missense_variant	1.0	ethambutol
embA	4245807	c.2575_2577delTTAinsCG	frameshift_variant&missense_variant	1.0	ethambutol	Uncertain significance
embB	4246292	c.-222A>G	upstream_gene_variant	1.0	ethambutol
embA	4246305	p.Ser1025Glu	missense_variant	1.0	ethambutol
embA	4246308	p.Thr1026Ala	missense_variant	1.0	ethambutol
embB	4247464	c.951C>G	synonymous_variant	0.9	ethambutol
embB	4247470	c.957T>C	synonymous_variant	0.92	ethambutol
embB	4247491	c.978G>C	synonymous_variant	0.94	ethambutol
embB	4247497	c.984T>C	synonymous_variant	0.94	ethambutol
embB	4247512	c.999T>C	synonymous_variant	0.92	ethambutol
embB	4247554	c.1041T>C	synonymous_variant	1.0	ethambutol
embB	4247566	c.1053C>A	synonymous_variant	1.0	ethambutol
embB	4247572	c.1059A>G	synonymous_variant	1.0	ethambutol
embB	4247579	p.Ala356Phe	missense_variant	0.91	ethambutol
embB	4247587	c.1074G>A	synonymous_variant	0.91	ethambutol
embB	4247588	c.1075_1077delCTAinsAC	frameshift_variant&missense_variant	0.91	ethambutol
embB	4247603	c.1090C>T	synonymous_variant	0.9	ethambutol
embB	4247611	c.1098G>T	synonymous_variant	0.82	ethambutol	Not assoc w R - Interim
embB	4247614	c.1101T>C	synonymous_variant	0.8	ethambutol	Not assoc w R - Interim
embB	4247746	c.1233C>T	synonymous_variant	0.7	ethambutol
embB	4247761	c.1248T>C	synonymous_variant	0.82	ethambutol
embB	4247773	c.1260G>A	synonymous_variant	0.85	ethambutol
embB	4247776	c.1263G>T	synonymous_variant	0.86	ethambutol
embB	4247797	c.1284C>G	synonymous_variant	0.87	ethambutol
embB	4247800	c.1287A>T	synonymous_variant	0.87	ethambutol
embB	4247803	c.1290G>C	synonymous_variant	0.87	ethambutol
embB	4247815	c.1302C>G	synonymous_variant	0.86	ethambutol
embB	4247819	c.1306_1308delGTTinsAC	frameshift_variant&missense_variant	0.92	ethambutol
embB	4247830	c.1317A>G	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4247836	c.1323A>G	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4247839	c.1326G>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4247866	c.1353G>C	synonymous_variant	0.94	ethambutol
embB	4247875	c.1362G>C	synonymous_variant	0.93	ethambutol
embB	4247876	c.1363C>T	synonymous_variant	0.93	ethambutol
embB	4247881	c.1368G>C	synonymous_variant	0.93	ethambutol
embB	4247887	c.1374C>T	synonymous_variant	0.93	ethambutol	Not assoc w R - Interim
embB	4247893	c.1380C>T	synonymous_variant	0.93	ethambutol
embB	4247899	p.Met462Ile	missense_variant	0.92	ethambutol
embB	4247905	c.1392G>C	synonymous_variant	0.92	ethambutol	Not assoc w R - Interim
embB	4247909	c.1396T>C	synonymous_variant	0.92	ethambutol
embB	4247914	c.1401G>C	synonymous_variant	0.92	ethambutol	Not assoc w R - Interim
embB	4247932	c.1419C>G	synonymous_variant	0.91	ethambutol
embB	4247940	p.Leu476Trp	missense_variant	0.92	ethambutol
embB	4247945	c.1432T>C	synonymous_variant	0.92	ethambutol
embB	4247951	p.Ser480Ala	missense_variant	0.91	ethambutol
embB	4247956	c.1443G>C	synonymous_variant	0.91	ethambutol	Not assoc w R - Interim
embB	4247974	c.1461C>G	synonymous_variant	0.82	ethambutol
embB	4248007	c.1494C>G	synonymous_variant	0.8	ethambutol
embB	4248035	p.Val508Ile	missense_variant	0.9	ethambutol
embB	4248157	c.1644A>G	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4248172	c.1659G>C	synonymous_variant	1.0	ethambutol
embB	4248199	c.1686A>G	synonymous_variant	1.0	ethambutol
embB	4248200	p.Ile563Val	missense_variant	1.0	ethambutol
embB	4248205	c.1692C>G	synonymous_variant	1.0	ethambutol
embB	4248206	c.1693_1695delAGCinsGT	frameshift_variant&missense_variant	1.0	ethambutol
embB	4248220	c.1707A>C	synonymous_variant	1.0	ethambutol
embB	4248304	c.1791G>C	synonymous_variant	1.0	ethambutol
embB	4248316	c.1803C>G	synonymous_variant	1.0	ethambutol
embB	4248319	c.1806A>G	synonymous_variant	1.0	ethambutol
embB	4248343	c.1830G>C	synonymous_variant	1.0	ethambutol
embB	4248350	c.1837T>C	synonymous_variant	1.0	ethambutol
embB	4248355	c.1842A>G	synonymous_variant	1.0	ethambutol
embB	4248358	c.1845C>G	synonymous_variant	1.0	ethambutol
embB	4248361	c.1848A>C	synonymous_variant	1.0	ethambutol
embB	4248362	p.Ser617Ala	missense_variant	1.0	ethambutol
embB	4248373	c.1860C>G	synonymous_variant	1.0	ethambutol
embB	4248382	c.1869C>G	synonymous_variant	1.0	ethambutol
embB	4248386	c.1873C>A	synonymous_variant	1.0	ethambutol
embB	4248407	c.1894_1896delTTAinsGG	frameshift_variant&missense_variant	1.0	ethambutol
embB	4248410	c.1897_1899delTTCinsCG	frameshift_variant&missense_variant	1.0	ethambutol
embB	4248419	p.Leu636Met	missense_variant	1.0	ethambutol
embB	4248425	c.1912T>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4248430	c.1917T>C	synonymous_variant	1.0	ethambutol
embB	4248432	p.Trp640Phe	missense_variant	1.0	ethambutol
embB	4248457	c.1944T>C	synonymous_variant	1.0	ethambutol
embB	4249444	c.2931T>C	synonymous_variant	0.8	ethambutol
embB	4249447	c.2934G>C	synonymous_variant	0.64	ethambutol
embB	4249469	p.Leu986Met	missense_variant	0.83	ethambutol
embB	4249486	c.2973T>G	synonymous_variant	0.81	ethambutol
embB	4249498	c.2985G>C	synonymous_variant	0.82	ethambutol
embB	4249521	p.Ala1003Val	missense_variant	0.83	ethambutol
embB	4249525	c.3012T>C	synonymous_variant	0.83	ethambutol	Not assoc w R - Interim
embB	4249529	p.Ile1006Val	missense_variant	0.83	ethambutol
embB	4249532	p.Ala1007Thr	missense_variant	0.83	ethambutol	Uncertain significance
embB	4249537	c.3024A>G	synonymous_variant	0.83	ethambutol
embB	4249543	c.3030G>C	synonymous_variant	0.82	ethambutol
embB	4249546	c.3033G>A	synonymous_variant	0.82	ethambutol
embB	4249558	c.3045A>C	synonymous_variant	0.82	ethambutol
embB	4249568	p.Ser1019Thr	missense_variant	0.81	ethambutol
embB	4249573	c.3060T>C	synonymous_variant	0.81	ethambutol
embB	4249580	p.Leu1023Met	missense_variant	0.8	ethambutol
embB	4249594	c.3081G>C	synonymous_variant	0.83	ethambutol
aftB	4268117	c.720G>C	synonymous_variant	1.0	ethambutol
aftB	4268123	c.712_714delAGTinsGC	frameshift_variant&synonymous_variant	1.0	ethambutol	Uncertain significance
aftB	4268129	c.708T>G	synonymous_variant	1.0	ethambutol
aftB	4268138	c.699A>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
aftB	4268144	c.693T>C	synonymous_variant	1.0	ethambutol
aftB	4268164	p.Gln225Glu	missense_variant	1.0	ethambutol
aftB	4268169	p.Ala223Gly	missense_variant	1.0	ethambutol
aftB	4268171	c.666G>C	synonymous_variant	1.0	ethambutol
aftB	4268179	c.658T>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
aftB	4268182	p.Phe219Leu	missense_variant	1.0	ethambutol
aftB	4268183	c.654A>T	synonymous_variant	1.0	ethambutol
aftB	4268193	p.Leu215Ala	missense_variant	1.0	ethambutol
aftB	4268205	p.Val211Ala	missense_variant	1.0	ethambutol

TB-Profiler result