TB-Profiler result

Run: SRR15368973

Summary

Run ID: SRR15368973

Sample name:

Date: 2024-03-26T17:04:12.403463

Number of reads: 290667

Percentage reads mapped: 4.14

Median coverage: 8.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.2.BCG M.bovis None 0.07
lineage4.9 Euro-American (H37Rv-like) None 0.89
lineage6.2.1 West-Africa 2 RD702 0.07
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.85 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 795 c.795A>C synonymous_variant 0.7 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.73 isoniazid Uncertain significance
dnaA 819 c.819C>T synonymous_variant 0.73 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.73 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.73 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.73 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.73 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.73 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.73 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.55 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.73 isoniazid Not assoc w R - Interim
dnaA 1137 c.1137C>G synonymous_variant 1.0 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.92 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.91 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.91 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.9 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.9 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.9 isoniazid Not assoc w R - Interim
dnaA 1188 c.1188G>A synonymous_variant 0.9 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.9 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.92 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.92 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.83 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.85 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.86 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.85 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.85 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.87 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.79 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.86 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.85 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.92 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.92 isoniazid Not assoc w R - Interim
dnaA 1302 c.1302C>G synonymous_variant 0.92 isoniazid
dnaA 1311 c.1311C>G synonymous_variant 0.92 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.92 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.92 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.93 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.94 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.94 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.94 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 1.0 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 1.0 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 1.0 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 1.0 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 1.0 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 1.0 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 1.0 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 1.0 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 1.0 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.93 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 1.0 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.92 isoniazid
dnaA 1455 c.1455C>A synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 1461 c.1461C>G synonymous_variant 1.0 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 1.0 isoniazid
gyrB 6196 c.957C>T synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 1.0 levofloxacin
moxifloxacin
gyrB 6256 c.1017G>A synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7051 p.Glu604Asp missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.94 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8729 c.1428T>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.92 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.92 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.92 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.85 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.86 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.94 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8933 c.1632G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9050 p.Asp583Glu missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
fgd1 490827 c.45C>T synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.92 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490935 c.153C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
mshA 575674 c.327G>C synonymous_variant 0.91 ethionamide
isoniazid
mshA 575701 c.354G>A synonymous_variant 0.8 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.82 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.86 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.92 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.87 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.93 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.92 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.92 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.92 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.92 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.92 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.92 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.92 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.92 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.93 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.92 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.92 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 1.0 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 1.0 ethionamide
isoniazid Not assoc w R - Interim
ccsA 619507 c.-384A>G upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.93 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.93 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620274 c.384G>C synonymous_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.93 capreomycin
amikacin
kanamycin
ccsA 620284 c.394_396delGCGinsCC frameshift_variant&missense_variant 0.93 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.91 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.92 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.91 capreomycin
amikacin
kanamycin
Rv0565c 657734 c.-264T>C upstream_gene_variant 1.0 ethionamide
hadA 732305 p.Ile126Val missense_variant 0.82 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.82 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.83 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.85 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.88 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.94 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.92 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.92 isoniazid
nusG 734421 c.168A>G synonymous_variant 1.0 rifampicin
nusG 734424 c.171G>A synonymous_variant 1.0 rifampicin
nusG 734442 c.189G>A synonymous_variant 1.0 rifampicin
nusG 734451 c.198G>C synonymous_variant 1.0 rifampicin
nusG 734457 c.204C>G synonymous_variant 1.0 rifampicin
nusG 734472 c.219T>C synonymous_variant 1.0 rifampicin
nusG 734475 c.222T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 1.0 rifampicin
nusG 734596 c.343T>C synonymous_variant 1.0 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.9 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.92 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.83 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.91 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.91 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.92 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.92 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.92 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.93 rifampicin
rpoB 760412 c.606C>G synonymous_variant 1.0 rifampicin
rpoB 760424 c.618C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760472 c.666C>T synonymous_variant 0.73 rifampicin
rpoB 760475 c.669A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 1.0 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 1.0 rifampicin
rpoB 760541 c.735G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 1.0 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 1.0 rifampicin
rpoB 760611 c.805T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 1.0 rifampicin
rpoB 760674 c.868T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 1.0 rifampicin
rpoB 760718 c.912C>T synonymous_variant 1.0 rifampicin
rpoB 760724 c.918T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760793 c.987A>G synonymous_variant 0.8 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.8 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.83 rifampicin
rpoB 760869 p.Val355Ile missense_variant 0.82 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.85 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.94 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.93 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.94 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.93 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.93 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761087 c.1281C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.94 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 1.0 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 1.0 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 1.0 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 1.0 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.83 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.8 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761747 c.1941G>C synonymous_variant 0.9 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.9 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.9 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 1.0 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.86 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.85 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.83 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.79 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.76 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.64 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.69 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.56 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.59 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.95 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.9 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.8 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.8 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.8 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.79 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.81 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.88 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 1.0 rifampicin
rpoC 763492 c.123G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.82 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.74 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.75 rifampicin
rpoC 763738 c.369G>A synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.76 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.81 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.82 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.83 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.87 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.91 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.95 rifampicin
rpoC 763858 c.489A>G synonymous_variant 1.0 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 1.0 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 1.0 rifampicin
rpoC 763879 c.510A>G synonymous_variant 1.0 rifampicin
rpoC 763888 c.519G>C synonymous_variant 1.0 rifampicin
rpoC 763891 c.522G>C synonymous_variant 1.0 rifampicin
rpoC 763894 c.525A>G synonymous_variant 1.0 rifampicin
rpoC 763900 c.531G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.92 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.85 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.83 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.82 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.82 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.8 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.82 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.82 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.82 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.82 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.83 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.9 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.91 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.91 rifampicin
rpoC 764188 c.819A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 1.0 rifampicin
rpoC 764203 c.834G>C synonymous_variant 1.0 rifampicin
rpoC 764206 c.837T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 1.0 rifampicin
rpoC 764236 c.867G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 1.0 rifampicin
rpoC 764266 c.897T>C synonymous_variant 1.0 rifampicin
rpoC 764269 c.900G>C synonymous_variant 1.0 rifampicin
rpoC 764272 c.903G>C synonymous_variant 1.0 rifampicin
rpoC 764278 c.909A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 1.0 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.92 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 1.0 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.85 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.95 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 1.0 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.93 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1643delAGinsTC synonymous_variant 0.85 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.86 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.85 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.91 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 1.0 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 1.0 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 1.0 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 1.0 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 1.0 rifampicin
rpoC 765613 p.His748Gln missense_variant 1.0 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 1.0 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765772 c.2403C>G synonymous_variant 1.0 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 1.0 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 1.0 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 1.0 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 1.0 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.94 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 1.0 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.93 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.92 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.93 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.94 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.94 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 1.0 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 1.0 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 1.0 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 1.0 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766142 c.2773C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 1.0 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 1.0 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 1.0 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 1.0 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 1.0 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 1.0 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 1.0 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 1.0 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 1.0 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 1.0 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 1.0 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 1.0 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 1.0 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 1.0 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 1.0 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 1.0 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 1.0 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 1.0 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 1.0 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 1.0 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 1.0 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 1.0 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 1.0 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 1.0 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 1.0 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 1.0 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 1.0 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 1.0 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 1.0 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 1.0 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 1.0 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 1.0 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.93 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.83 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.83 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.77 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.83 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.91 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.91 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.54 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.92 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.93 streptomycin
rpsL 781715 c.156T>C synonymous_variant 1.0 streptomycin
rpsL 781728 c.169T>C synonymous_variant 1.0 streptomycin
rpsL 781736 c.177T>C synonymous_variant 1.0 streptomycin
rpsL 781742 c.183C>T synonymous_variant 1.0 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.88 streptomycin
rpsL 781754 c.195G>C synonymous_variant 1.0 streptomycin
rpsL 781760 c.201T>C synonymous_variant 1.0 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.89 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.92 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.92 streptomycin
rpsL 781832 c.273T>C synonymous_variant 1.0 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.9 streptomycin
rpsL 781841 c.282C>G synonymous_variant 1.0 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.8 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.9 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.9 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.82 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.9 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.92 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.92 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.93 streptomycin Uncertain significance
rplC 801423 c.615G>C synonymous_variant 1.0 linezolid
rplC 801426 c.618C>G synonymous_variant 1.0 linezolid
rplC 801427 p.Met207Val missense_variant 1.0 linezolid
rplC 801438 c.630T>C synonymous_variant 1.0 linezolid
rplC 801442 p.Ile212Val missense_variant 1.0 linezolid
fbiC 1303590 c.660A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.9 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472240 n.395G>C non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472242 n.397C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472251 n.406G>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472252 n.407G>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472253 n.408G>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472256 n.411T>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472374 n.529T>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472541 n.696T>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472553 n.708C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472572 n.727T>C non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1472574 n.729T>C non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472579 n.734_735delGCinsACGA non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472582 n.738_739delTA non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472594 n.749G>C non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472598 n.753A>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472754 n.909G>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
inhA 1673535 c.-667A>G upstream_gene_variant 0.73 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.82 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.82 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.83 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.83 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.83 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.87 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.86 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674726 c.525G>A synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.91 ethionamide
isoniazid
inhA 1674864 c.663C>T synonymous_variant 0.82 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.8 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.83 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.8 ethionamide
isoniazid
rpsA 1833595 c.54T>C synonymous_variant 0.9 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.93 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.93 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.92 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.93 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.92 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 1.0 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.69 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.62 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.62 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.57 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.57 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.57 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834510 c.969C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 1.0 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 1.0 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 1.0 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 1.0 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 1.0 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 1.0 linezolid
tsnR 1853426 c.-180G>A upstream_gene_variant 0.71 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 1.0 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 1.0 linezolid
tlyA 1918002 c.63A>G synonymous_variant 1.0 capreomycin
tlyA 1918036 p.Arg33Ser missense_variant 1.0 capreomycin
tlyA 1918048 p.Leu37Met missense_variant 1.0 capreomycin
bacA 2064948 c.-220G>C upstream_gene_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.93 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101912 c.1131G>C synonymous_variant 0.8 ethionamide
delamanid
isoniazid
ndh 2101920 c.1123A>C synonymous_variant 0.8 ethionamide
delamanid
isoniazid
ndh 2101924 c.1119T>G synonymous_variant 0.8 ethionamide
delamanid
isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 1.0 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.91 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.92 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.83 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.85 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.86 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.92 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.92 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.92 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.91 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.92 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.92 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.92 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.92 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.93 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.93 isoniazid
kasA 2518744 c.630C>T synonymous_variant 1.0 isoniazid
kasA 2518747 c.633C>G synonymous_variant 1.0 isoniazid
kasA 2518768 c.654C>T synonymous_variant 1.0 isoniazid
kasA 2518777 c.663C>T synonymous_variant 1.0 isoniazid
kasA 2518783 c.669T>C synonymous_variant 1.0 isoniazid
kasA 2518789 c.675G>C synonymous_variant 1.0 isoniazid
kasA 2518792 c.678C>A synonymous_variant 1.0 isoniazid
kasA 2518795 c.681C>G synonymous_variant 1.0 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.94 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.92 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.93 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.92 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.92 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.83 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.75 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.7 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.73 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.75 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.75 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.75 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.75 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.82 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.8 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.7 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.7 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.82 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.82 isoniazid
kasA 2519056 c.942G>C synonymous_variant 0.82 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.92 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.92 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.92 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.9 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.9 isoniazid
ahpC 2726564 c.372C>G synonymous_variant 0.82 isoniazid Not assoc w R - Interim
ahpC 2726591 c.399C>G synonymous_variant 0.92 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.92 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.93 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.93 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 1.0 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 1.0 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv2477c 2782981 c.1062G>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.91 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783650 c.393C>T synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783656 c.387G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065007 c.1185G>C synonymous_variant 0.8 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065013 c.1179G>C synonymous_variant 0.8 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065018 p.Asn392His missense_variant 0.8 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065022 c.1170G>A synonymous_variant 0.9 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1162_1164delGTGinsAC frameshift_variant&missense_variant 0.92 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065040 c.1152C>G synonymous_variant 0.91 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.9 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
thyX 3067325 c.621A>G synonymous_variant 0.92 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.92 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067442 c.504C>T synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 1.0 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067510 c.436C>T synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 1.0 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 1.0 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 1.0 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 1.0 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 1.0 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 1.0 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 1.0 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.92 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067775 c.171C>T synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.92 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.92 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.9 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074100 c.370_372delGATinsAC frameshift_variant&synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074360 c.112T>C synonymous_variant 0.91 para-aminosalicylic_acid
thyA 3074361 c.111T>C synonymous_variant 0.91 para-aminosalicylic_acid
thyA 3074372 p.Met34Leu missense_variant 0.93 para-aminosalicylic_acid
thyA 3074377 p.Gln32Arg missense_variant 0.93 para-aminosalicylic_acid
thyA 3074391 c.81C>A synonymous_variant 0.92 para-aminosalicylic_acid
thyA 3074423 p.Pro17Ala missense_variant 0.8 para-aminosalicylic_acid
thyA 3074427 c.45T>A synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3074431 p.Thr14Glu missense_variant 0.8 para-aminosalicylic_acid
thyA 3074433 p.Glu13Asp missense_variant 0.8 para-aminosalicylic_acid
thyA 3074442 c.28_30delTTCinsCG frameshift_variant&missense_variant 0.8 para-aminosalicylic_acid
thyA 3074445 c.27C>A synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3074448 c.24G>C synonymous_variant 0.8 para-aminosalicylic_acid
lpqB 3625134 c.-224T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.93 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.92 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.92 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 1.0 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.95 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.95 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.95 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.96 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.96 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.96 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.96 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.96 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.96 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.96 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.96 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.96 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625792 c.-882G>A upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625797 p.Val273Met missense_variant 0.96 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.94 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625843 c.-933C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.91 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626945 c.-332C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.162A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
fbiB 3642581 c.1047A>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642587 p.Met351Ile missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642593 c.1059G>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642609 c.1075_1076delAGinsTC synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642617 c.1083C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiB 3642659 c.1125C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiB 3642719 c.1185T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
rpoA 3877571 p.Pro313Ala missense_variant 1.0 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.94 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.95 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.95 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877701 c.807G>A synonymous_variant 0.35 rifampicin
rpoA 3877704 c.804G>C synonymous_variant 0.94 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.88 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.92 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 1.0 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 1.0 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 1.0 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 1.0 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 1.0 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 1.0 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 1.0 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 1.0 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 1.0 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 1.0 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.96 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.95 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.95 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.95 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.94 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.94 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.94 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.94 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.92 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.91 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.9 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 1.0 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 1.0 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 1.0 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 1.0 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 1.0 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 1.0 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 1.0 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.93 rifampicin Uncertain significance
rpoA 3878893 c.-386C>T upstream_gene_variant 0.56 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.93 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.93 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.93 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 1.0 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 1.0 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 1.0 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.95 rifampicin
rpoA 3879082 c.-575C>T upstream_gene_variant 0.3 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.95 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.95 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 1.0 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 1.0 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 1.0 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 1.0 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 1.0 rifampicin
clpC1 4038433 c.2272C>T synonymous_variant 0.91 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.91 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.92 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.92 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.85 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.85 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.85 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.85 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.86 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 1.0 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 1.0 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 1.0 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.93 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.92 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038893 c.1812C>T synonymous_variant 0.57 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.92 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.92 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 1.0 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.91 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.93 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 1.0 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.94 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.91 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.91 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.9 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.9 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.9 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.92 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.85 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.85 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.85 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.85 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.9 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.9 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 1.0 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 1.0 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.86 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.92 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.92 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.92 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 1.0 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040279 c.426C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.93 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.93 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.91 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.82 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.82 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.8 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 1.0 pyrazinamide
panD 4044926 c.-645C>A upstream_gene_variant 1.0 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 1.0 pyrazinamide
panD 4044935 c.-655_-654delAAinsTG upstream_gene_variant 1.0 pyrazinamide
panD 4044941 c.-660G>C upstream_gene_variant 1.0 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 1.0 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 1.0 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 1.0 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 1.0 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 1.0 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 1.0 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 1.0 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 1.0 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 1.0 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 1.0 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 1.0 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 1.0 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 1.0 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 1.0 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 1.0 pyrazinamide
glpK 4138654 c.1102C>T synonymous_variant 0.79 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.83 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240726 c.864G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 1.0 ethambutol
embC 4240783 c.921G>C synonymous_variant 1.0 ethambutol
embC 4240789 c.927T>C synonymous_variant 1.0 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.82 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.9 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.9 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.9 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.9 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>G synonymous_variant 1.0 ethambutol
embC 4241536 c.1674A>G synonymous_variant 1.0 ethambutol
embC 4241539 c.1677T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 1.0 ethambutol
embC 4241548 c.1686T>C synonymous_variant 1.0 ethambutol
embC 4241551 c.1689A>G synonymous_variant 1.0 ethambutol
embC 4241567 p.Ile569Val missense_variant 1.0 ethambutol
embC 4242791 c.2929_2931delGCAinsTC frameshift_variant&missense_variant 0.9 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.9 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.9 ethambutol
embA 4242802 c.-431G>C upstream_gene_variant 0.91 ethambutol
embA 4242820 c.-413G>C upstream_gene_variant 0.92 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.92 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.92 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.92 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.92 ethambutol Not assoc w R - Interim
embA 4242844 c.-389A>G upstream_gene_variant 0.92 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.92 ethambutol
embA 4242859 c.-374C>T upstream_gene_variant 0.92 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 1.0 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 1.0 ethambutol
embC 4242883 c.3021C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4242892 c.-341G>C upstream_gene_variant 1.0 ethambutol
embA 4242901 c.-332G>C upstream_gene_variant 1.0 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.9 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.91 ethambutol
embA 4245137 c.1905T>C synonymous_variant 1.0 ethambutol
embA 4245146 c.1914G>A synonymous_variant 1.0 ethambutol
embA 4245149 c.1917C>G synonymous_variant 1.0 ethambutol
embA 4245153 p.Ile641Val missense_variant 1.0 ethambutol
embA 4245182 c.1950T>C synonymous_variant 1.0 ethambutol
embA 4245189 c.1957C>T synonymous_variant 1.0 ethambutol
embA 4245198 p.Leu656Ile missense_variant 1.0 ethambutol
embA 4245807 c.2575_2577delTTAinsCG frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
embB 4246292 c.-222A>G upstream_gene_variant 1.0 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 1.0 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 1.0 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.9 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.92 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.94 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.94 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.92 ethambutol
embB 4247554 c.1041T>C synonymous_variant 1.0 ethambutol
embB 4247566 c.1053C>A synonymous_variant 1.0 ethambutol
embB 4247572 c.1059A>G synonymous_variant 1.0 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.91 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.91 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.91 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.9 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.82 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.8 ethambutol Not assoc w R - Interim
embB 4247746 c.1233C>T synonymous_variant 0.7 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.82 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.85 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.86 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.87 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.87 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.87 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.86 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.92 ethambutol
embB 4247830 c.1317A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.94 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.93 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.93 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.93 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.93 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.93 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.92 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.92 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.92 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.92 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.91 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.92 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.92 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.91 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.91 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.82 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.8 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.9 ethambutol
embB 4248157 c.1644A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 1.0 ethambutol
embB 4248199 c.1686A>G synonymous_variant 1.0 ethambutol
embB 4248200 p.Ile563Val missense_variant 1.0 ethambutol
embB 4248205 c.1692C>G synonymous_variant 1.0 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 1.0 ethambutol
embB 4248220 c.1707A>C synonymous_variant 1.0 ethambutol
embB 4248304 c.1791G>C synonymous_variant 1.0 ethambutol
embB 4248316 c.1803C>G synonymous_variant 1.0 ethambutol
embB 4248319 c.1806A>G synonymous_variant 1.0 ethambutol
embB 4248343 c.1830G>C synonymous_variant 1.0 ethambutol
embB 4248350 c.1837T>C synonymous_variant 1.0 ethambutol
embB 4248355 c.1842A>G synonymous_variant 1.0 ethambutol
embB 4248358 c.1845C>G synonymous_variant 1.0 ethambutol
embB 4248361 c.1848A>C synonymous_variant 1.0 ethambutol
embB 4248362 p.Ser617Ala missense_variant 1.0 ethambutol
embB 4248373 c.1860C>G synonymous_variant 1.0 ethambutol
embB 4248382 c.1869C>G synonymous_variant 1.0 ethambutol
embB 4248386 c.1873C>A synonymous_variant 1.0 ethambutol
embB 4248407 c.1894_1896delTTAinsGG frameshift_variant&missense_variant 1.0 ethambutol
embB 4248410 c.1897_1899delTTCinsCG frameshift_variant&missense_variant 1.0 ethambutol
embB 4248419 p.Leu636Met missense_variant 1.0 ethambutol
embB 4248425 c.1912T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248430 c.1917T>C synonymous_variant 1.0 ethambutol
embB 4248432 p.Trp640Phe missense_variant 1.0 ethambutol
embB 4248457 c.1944T>C synonymous_variant 1.0 ethambutol
embB 4249444 c.2931T>C synonymous_variant 0.8 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.64 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.83 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.81 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.82 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.83 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.83 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.83 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.83 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.83 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.82 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.82 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.82 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.81 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.81 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.8 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.83 ethambutol
aftB 4268117 c.720G>C synonymous_variant 1.0 ethambutol
aftB 4268123 c.712_714delAGTinsGC frameshift_variant&synonymous_variant 1.0 ethambutol Uncertain significance
aftB 4268129 c.708T>G synonymous_variant 1.0 ethambutol
aftB 4268138 c.699A>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 1.0 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 1.0 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 1.0 ethambutol
aftB 4268171 c.666G>C synonymous_variant 1.0 ethambutol
aftB 4268179 c.658T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 1.0 ethambutol
aftB 4268183 c.654A>T synonymous_variant 1.0 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 1.0 ethambutol
aftB 4268205 p.Val211Ala missense_variant 1.0 ethambutol