TB-Profiler result

Run: ERR4821686
Summary

Run ID: ERR4821686

Sample name:

Date: 2024-04-16T07:25:13.621590

Number of reads: 2216368

Percentage reads mapped: 58.18

Median coverage: 48.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 1.0
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 708 c.708T>C synonymous_variant 0.12 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.13 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 747 c.747G>T synonymous_variant 0.16 isoniazid
dnaA 748 c.748_750delCTCinsTG frameshift_variant&missense_variant 0.16 isoniazid Uncertain significance
dnaA 763 p.Lys255Arg missense_variant 0.17 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.21 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.25 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.22 isoniazid
dnaA 804 c.804G>C synonymous_variant 0.22 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.22 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.25 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.18 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.18 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.19 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.19 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.2 isoniazid Not assoc w R - Interim
gyrB 6151 c.912C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6184 c.945C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6193 c.954G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.25 levofloxacin Uncertain significance
moxifloxacin
gyrA 6739 c.-563C>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6754 c.-548C>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6772 c.1533C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.16 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7081 c.-221T>C upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7135 c.-167G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7156 c.1917C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7403 c.102C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7424 c.123G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7439 c.138C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7451 c.150C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7526 c.225G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7589 c.288G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7637 c.336C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8327 c.1026C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8330 c.1029C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8354 c.1053G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8649 p.Arg450Lys missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8666 c.1365G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8837 c.1536C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8846 c.1545C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8957 c.1656C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Lys missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13423 p.Gly46Arg missense_variant 1.0 isoniazid Uncertain significance
fgd1 491591 p.Lys270Met missense_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575734 c.387T>G synonymous_variant 0.15 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575740 c.393G>T synonymous_variant 0.16 ethionamide
isoniazid
mshA 575743 c.396C>T synonymous_variant 0.16 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575744 p.Ala133Thr missense_variant 0.16 ethionamide
isoniazid Uncertain significance
mshA 575755 c.408G>A synonymous_variant 0.16 ethionamide
isoniazid
mshA 575761 c.414C>G synonymous_variant 0.14 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.15 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.12 ethionamide
isoniazid
ccsA 619687 c.-204G>A upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620322 c.432G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620328 c.438G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620338 c.448_450delACCinsGG frameshift_variant&missense_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620354 p.Trp155Tyr missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620365 p.Asn159Tyr missense_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620397 c.507C>G synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.18 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
nusG 734445 c.192C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 0.2 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.28 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734535 c.282C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734580 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734586 c.333G>C synonymous_variant 0.17 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760110 c.304_306delTCTinsAGC synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760115 c.309C>T synonymous_variant 0.79 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.27 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.17 rifampicin Uncertain significance
rpoB 760276 p.Lys157Met missense_variant 0.15 rifampicin Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760608 c.802C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.4 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.18 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.19 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.29 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760886 p.Glu360Asp missense_variant 0.31 rifampicin Uncertain significance
rpoB 760887 p.Thr361Val missense_variant 0.32 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760943 c.1137C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.21 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.23 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.24 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.25 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.15 rifampicin
rpoB 761954 c.2148C>A synonymous_variant 0.13 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.13 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762122 c.2316C>T synonymous_variant 0.22 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.17 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.17 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.16 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.16 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762866 c.3060C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.22 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.21 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.2 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.2 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.2 rifampicin
rpoC 763960 c.591T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.26 rifampicin
rpoC 763991 c.622_624delATCinsCT frameshift_variant&missense_variant 0.25 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.23 rifampicin
rpoC 763999 c.630C>T synonymous_variant 0.23 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.25 rifampicin
rpoC 764003 p.Ala212Ser missense_variant 0.25 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.24 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.25 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.27 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.3 rifampicin
rpoC 764054 c.685C>T synonymous_variant 0.28 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.21 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.35 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.38 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764534 c.1165C>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.34 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.43 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.43 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.4 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.97 rifampicin Not assoc w R
rpoC 765403 c.2034G>C synonymous_variant 0.26 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.25 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.33 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.24 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 0.24 rifampicin Uncertain significance
rpoC 765499 c.2130C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765841 c.2472G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765861 p.Phe831Tyr missense_variant 0.21 rifampicin Uncertain significance
rpoC 765875 p.Val836Ile missense_variant 0.24 rifampicin Uncertain significance
rpoC 765907 c.2538G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766573 c.3204T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766594 c.3225G>T synonymous_variant 0.21 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767179 c.3810C>T synonymous_variant 0.18 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 0.18 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781276 c.-284A>C upstream_gene_variant 1.0 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781586 c.27C>T synonymous_variant 0.23 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.23 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.28 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.34 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.39 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.4 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.39 streptomycin
rpsL 781658 c.99A>C synonymous_variant 0.38 streptomycin Not assoc w R - Interim
rpsL 781670 c.111G>C synonymous_variant 0.32 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.13 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.19 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.22 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.22 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.23 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.39 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.35 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.32 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.28 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.26 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.25 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.23 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.21 streptomycin
atpE 1461132 p.Val30Ile missense_variant 0.19 bedaquiline
atpE 1461146 c.102G>T synonymous_variant 0.24 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.24 bedaquiline
atpE 1461161 c.117C>G synonymous_variant 0.26 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.25 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.26 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.26 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.27 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.25 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.25 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.24 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.2 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674912 c.711G>C synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674949 c.748C>T synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674954 c.753G>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674957 c.756G>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674963 c.762G>C synonymous_variant 0.17 ethionamide
isoniazid
rpsA 1833589 c.48A>C synonymous_variant 0.19 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.2 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.21 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.27 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.28 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.22 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.28 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.28 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.28 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.25 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.3 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.35 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834228 c.687C>A synonymous_variant 0.22 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834234 c.693G>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.24 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>T synonymous_variant 0.23 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.2 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.23 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834375 c.834G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834520 c.979_981delGCCinsTG frameshift_variant&missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834528 c.987T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834534 c.993C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.14 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.26 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834645 c.1104C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.36 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834698 c.1157_1158insC frameshift_variant 0.24 pyrazinamide Uncertain significance
rpsA 1834701 p.Gln387Pro missense_variant 0.24 pyrazinamide
rpsA 1834704 c.1164delC frameshift_variant 0.24 pyrazinamide Uncertain significance
rpsA 1834720 c.1179C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.23 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.23 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.22 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.23 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>C upstream_gene_variant 0.24 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.22 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518738 c.624G>C synonymous_variant 0.19 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.28 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.26 isoniazid
kasA 2518771 c.657C>G synonymous_variant 0.26 isoniazid
kasA 2518774 c.660C>T synonymous_variant 0.25 isoniazid
kasA 2518783 c.669T>G synonymous_variant 0.24 isoniazid
kasA 2518787 p.Arg225Lys missense_variant 0.24 isoniazid
kasA 2518792 c.678C>T synonymous_variant 0.23 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.24 isoniazid
kasA 2518798 c.684G>C synonymous_variant 0.24 isoniazid
kasA 2518822 c.708C>A synonymous_variant 0.23 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid
Rv2477c 2783311 c.732T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783347 c.696C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783491 c.552C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783509 c.534C>A synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783515 c.528C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783523 c.520C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.5 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.26 capreomycin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448706 p.Pro68Leu missense_variant 1.0 ethionamide
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625705 c.909C>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625708 c.906C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625720 c.894G>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625744 c.870G>A synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626704 c.-91C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626756 c.594C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626786 c.564A>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626825 c.525T>A synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626846 c.504G>A synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627053 c.297C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627056 c.294C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627059 c.291G>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627068 c.282T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627073 c.277C>T synonymous_variant 0.24 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627133 p.Ala73Ser missense_variant 0.22 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627143 c.-530G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627149 c.-536G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627152 c.-539C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
rpoA 3877569 c.937_939delCCGinsAC frameshift_variant&missense_variant 0.16 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877614 c.894G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877620 c.888G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877677 c.831G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877824 c.684G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>A synonymous_variant 0.39 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.28 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.31 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.34 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878343 c.165C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.3 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.27 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.28 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.26 rifampicin
rpoA 3878373 c.135G>C synonymous_variant 0.26 rifampicin
rpoA 3878381 c.127C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878391 c.117T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878400 c.108T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3879073 c.-566A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879079 c.-572A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.25 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879097 c.-590C>T upstream_gene_variant 0.27 rifampicin
rpoA 3879121 c.-615_-614delTTinsAG upstream_gene_variant 0.29 rifampicin
rpoA 3879124 c.-618_-617delTGinsGC upstream_gene_variant 0.29 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.29 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.3 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.25 rifampicin
clpC1 4038737 c.1968C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.18 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.24 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.29 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.25 pyrazinamide
clpC1 4038857 c.1848C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.23 pyrazinamide
clpC1 4038923 c.1782A>T synonymous_variant 0.23 pyrazinamide
clpC1 4038928 c.1777C>A synonymous_variant 0.22 pyrazinamide
clpC1 4038929 c.1776G>A synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038932 c.1773G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039077 p.Lys543Arg missense_variant 0.26 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.26 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.3 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.45 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.46 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.41 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.39 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.23 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.37 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039619 c.1086G>A synonymous_variant 0.35 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039685 c.1020C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039733 c.972G>A synonymous_variant 0.23 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.41 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039868 c.837C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039957 c.748C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.42 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.34 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040126 c.579C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040174 c.531C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040426 c.279T>C synonymous_variant 0.13 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.13 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.22 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.21 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.2 pyrazinamide
glpK 4138601 c.1155G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138616 c.1140G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138664 c.1092G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240756 c.894G>C synonymous_variant 0.15 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.15 ethambutol
embC 4240772 p.Ser304Ala missense_variant 0.17 ethambutol
embC 4240778 p.His306Gly missense_variant 0.16 ethambutol
embC 4240781 p.Ala307Ser missense_variant 0.16 ethambutol Uncertain significance
embC 4240789 c.927T>C synonymous_variant 0.19 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.22 ethambutol
embC 4240826 p.Ala322Ser missense_variant 0.22 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.2 ethambutol
embC 4240856 c.994_996delGCGinsAC frameshift_variant&missense_variant 0.16 ethambutol
embC 4240859 c.997_999delCTGinsAC frameshift_variant&missense_variant 0.15 ethambutol
embC 4240876 c.1014C>T synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin