TB-Profiler result

Run: SRR1791696
Summary

Run ID: SRR1791696

Sample name:

Date: 2024-10-05T05:02:15.001566

Number of reads: 2214298

Percentage reads mapped: 82.13

Median coverage: 97.0

Strain: La1.8.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8 M.bovis None 0.98
La1.8.1 M.bovis None 0.97
La1 M.bovis None 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Leu359Ile Uncertain significance Mutation from literature
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance Mutation from literature
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
embB 4247588 p.Leu359Ile missense_variant 0.19 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
dnaA 786 c.786C>T synonymous_variant 0.16 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.16 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.17 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.18 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.17 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.18 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.17 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.17 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.18 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.17 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.17 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.18 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.17 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.18 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.19 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.21 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.2 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.19 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.2 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.18 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.2 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.21 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.18 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.17 isoniazid
dnaA 1293 c.1293T>G synonymous_variant 0.17 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.18 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.17 isoniazid
dnaA 1329 c.1329A>C synonymous_variant 0.17 isoniazid
dnaA 1332 c.1332A>T synonymous_variant 0.17 isoniazid
dnaA 1335 c.1335G>A synonymous_variant 0.17 isoniazid
dnaA 1338 c.1338T>C synonymous_variant 0.17 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.17 isoniazid
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6223 c.984G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6274 c.1035C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6406 c.1167C>T synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 0.93 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6700 c.-602T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.26 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.3 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6931 c.-371A>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6934 c.-368A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6937 c.1698G>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6955 c.-347G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7000 c.-302C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Thr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7442 c.141G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7622 c.321C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7649 c.348C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8285 c.984C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8351 c.1050C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419Gln missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8562 c.1261C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9217 p.Asp639Ala missense_variant 0.92 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491144 p.Ala121Asp missense_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491166 c.384G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491250 c.468G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 576105 p.Arg253Leu missense_variant 0.94 isoniazid Uncertain significance
ethionamide Uncertain significance
ccsA 620245 c.355T>C synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620249 p.Ser120Cys missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620254 c.364_366delCTCinsTTG synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620257 p.Ile123Val missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620269 p.Val127Ile missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620307 c.417C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620319 c.429C>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657719 c.-249C>G upstream_gene_variant 0.17 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.18 ethionamide
hadA 731792 c.-138G>A upstream_gene_variant 0.21 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.18 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.17 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.16 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.18 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.17 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.15 isoniazid
nusG 734580 c.327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734610 c.357C>G synonymous_variant 0.17 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.17 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.19 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.19 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.2 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.19 rifampicin
nusG 734715 c.462G>C synonymous_variant 0.19 rifampicin
nusG 734754 c.501G>C synonymous_variant 0.19 rifampicin
nusG 734757 c.504T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734778 c.525G>C synonymous_variant 0.26 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.26 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.27 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.26 rifampicin Uncertain significance
nusG 734820 c.567A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.21 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.19 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.2 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.19 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.17 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.17 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.18 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.17 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.17 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.16 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.17 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760514 c.708C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Ile missense_variant 0.15 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.17 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.28 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.24 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.3 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.29 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.29 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.28 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.27 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.27 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.28 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.27 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.27 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.27 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.29 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.26 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.25 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.25 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.21 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.2 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.21 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.2 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.19 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.2 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.18 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.17 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.17 rifampicin
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.18 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.18 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.22 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.22 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.19 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761437 p.Ala544Glu missense_variant 0.15 rifampicin
rpoB 761439 p.Asp545Asn missense_variant 0.15 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.16 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.19 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.19 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.23 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.19 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.21 rifampicin
rpoB 761723 c.1917_1919delAGAinsG frameshift_variant&synonymous_variant 0.17 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.19 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.2 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.19 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.22 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.21 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.22 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.21 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.23 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.23 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.21 rifampicin
rpoB 761847 p.Cys681Ser missense_variant 0.19 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.19 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.18 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.18 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.19 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.18 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.17 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.16 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.16 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.16 rifampicin
rpoB 761931 c.2125C>T synonymous_variant 0.16 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.18 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.17 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.16 rifampicin
rpoB 762062 c.2256T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.24 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.23 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.18 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.16 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.16 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.18 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.18 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.21 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.35 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.33 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.27 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.29 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.31 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.31 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.29 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.29 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.28 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.28 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.28 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.28 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.26 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.27 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.26 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.3 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.24 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.23 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.22 rifampicin
rpoC 763885 c.516C>G synonymous_variant 0.21 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.22 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.22 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.22 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.29 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.26 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.27 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.25 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.22 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.23 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.2 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.21 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.22 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.25 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.2 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.22 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.23 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.24 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.29 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.29 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.3 rifampicin
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.32 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.26 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.28 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.28 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.28 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.27 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.25 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTTG synonymous_variant 0.26 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.25 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.22 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.22 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.21 rifampicin
rpoC 765298 c.1929G>T synonymous_variant 0.15 rifampicin
rpoC 765325 c.1956C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765349 c.1980T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.22 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.24 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.25 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.26 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.29 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.29 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.3 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.28 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.27 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.27 rifampicin
rpoC 765573 p.Asp735Gly missense_variant 0.29 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.29 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.29 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.3 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.3 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.31 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.3 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.32 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.32 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.3 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.3 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.29 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.3 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.25 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.21 rifampicin
rpoC 766015 c.2646G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.21 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.21 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.2 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.2 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.19 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.2 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.16 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.18 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.19 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.21 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.28 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 0.27 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.28 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.29 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.29 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.31 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766528 c.3159T>G synonymous_variant 0.33 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.31 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.24 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.24 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.22 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.22 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.19 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.21 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.2 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.2 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.18 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.2 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.2 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.19 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.21 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.28 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.27 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.27 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.28 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.33 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.28 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.25 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.25 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.23 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.24 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.25 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.22 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.17 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.19 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.2 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.2 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.21 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.2 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.2 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.2 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.22 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.23 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.29 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.3 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.34 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.32 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.31 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.32 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.29 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.29 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.28 streptomycin Uncertain significance
rplC 800690 c.-119C>T upstream_gene_variant 0.16 linezolid
rplC 801357 c.549T>C synonymous_variant 0.18 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.2 linezolid
rplC 801396 c.588T>C synonymous_variant 0.18 linezolid
rplC 801402 c.594T>C synonymous_variant 0.17 linezolid
rplC 801405 c.597T>C synonymous_variant 0.18 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
fbiC 1303590 c.660A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303611 c.681G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303617 c.687C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303638 c.708A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303881 c.951G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303981 p.Val351Ile missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303995 c.1065C>T synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304634 c.1704C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Glu missense_variant 0.15 pretomanid
delamanid
clofazimine
sigE 1364835 c.423C>G synonymous_variant 0.19 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.19 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.19 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.2 pyrazinamide
sigE 1364866 p.Ala152Ser missense_variant 0.2 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.22 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.18 pyrazinamide
sigE 1364928 c.516C>T synonymous_variant 0.15 pyrazinamide
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474025 n.368T>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475403 n.1746T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476384 n.2727G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476755 n.3098G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
inhA 1674486 c.285T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.19 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.16 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674627 c.426T>G synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674693 c.492C>G synonymous_variant 0.17 isoniazid
ethionamide
rpsA 1833541 c.-1T>C upstream_gene_variant 0.18 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.23 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.24 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.22 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.22 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834097 p.Ser186Thr missense_variant 0.16 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.25 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.27 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.23 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834528 c.987T>G synonymous_variant 0.3 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.31 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.25 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.21 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.21 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 0.98 pyrazinamide Uncertain significance
tsnR 1853361 c.-245T>C upstream_gene_variant 0.33 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.31 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.31 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.31 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.3 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.23 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.24 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.22 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.19 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.18 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
ndh 2103173 c.-132delG upstream_gene_variant 1.0 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517947 c.-168C>T upstream_gene_variant 0.16 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.17 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.24 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.27 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.27 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.27 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.31 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.31 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.31 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.31 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.32 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.31 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.32 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.33 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.3 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.31 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.32 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.33 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.31 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.29 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.28 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.28 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.23 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.22 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.21 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.21 isoniazid
kasA 2518888 c.774C>T synonymous_variant 0.2 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.16 isoniazid
eis 2715125 p.Thr70Ala missense_variant 1.0 kanamycin Uncertain significance
amikacin Uncertain significance
eis 2715719 c.-387C>T upstream_gene_variant 1.0 kanamycin
amikacin
folC 2747293 c.306G>A synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.17 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.18 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747401 c.198G>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747407 c.192T>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747411 p.Ser63Ala missense_variant 0.16 para-aminosalicylic_acid
folC 2747416 c.183A>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747419 c.180C>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747430 c.169C>T synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747443 c.156G>A synonymous_variant 0.16 para-aminosalicylic_acid
Rv2477c 2782927 c.1116A>G synonymous_variant 0.95 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783040 p.Ala335Thr missense_variant 0.19 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783133 p.Leu304Phe missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783578 p.Glu155Asp missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.27 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783755 c.288C>T synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.22 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2680 2995832 c.-273G>A upstream_gene_variant 0.98 capreomycin
Rv2681 2997325 p.Ala196Val missense_variant 0.99 capreomycin Uncertain significance
Rv2752c 3066041 p.Gly51Ser missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3066050 p.Leu48Met missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066054 c.138T>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066075 c.117A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066087 c.105A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3066543 c.-352C>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066589 c.-398G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066644 c.-453T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067316 c.630A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067500 p.Lys149Arg missense_variant 0.17 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.23 para-aminosalicylic_acid
thyX 3067526 c.420C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.21 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.2 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.19 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.18 para-aminosalicylic_acid
thyX 3067559 p.Arg129Gln missense_variant 0.18 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.19 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.18 para-aminosalicylic_acid
thyX 3067571 c.375C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067577 p.Glu123Asp missense_variant 0.18 para-aminosalicylic_acid
thyX 3067582 p.Met122Leu missense_variant 0.18 para-aminosalicylic_acid
thyX 3067586 c.360C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067601 c.345G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067604 c.342G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067610 p.Lys112Asn missense_variant 0.2 para-aminosalicylic_acid
thyX 3067613 c.333G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067640 c.306G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.18 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.18 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073893 c.579C>A synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.17 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623372 c.1539G>C synonymous_variant 1.0 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3623730 p.Ser394Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 0.95 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624593 c.318G>A synonymous_variant 0.92 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3624710 c.201G>A synonymous_variant 0.92 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625569 c.1045T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.17 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625592 p.Ser341Asn missense_variant 0.17 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625627 c.-717C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.16 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626780 c.-167T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627139 c.-526T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627170 c.-557C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627188 c.-577_-575delTTAinsCTG upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627191 c.-578G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.19 rifampicin
bedaquiline
fbiB 3641590 p.Gly19Glu missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine
fbiB 3642614 c.1080C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
rpoA 3877494 p.Glu338Asp missense_variant 0.17 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.19 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.19 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.21 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.22 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.22 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.21 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.19 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877793 p.Ala239Pro missense_variant 0.17 rifampicin
rpoA 3877794 c.714G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.18 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.2 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.24 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.26 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.25 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.29 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.28 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.28 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.3 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.3 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.27 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.27 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.26 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.25 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.24 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.24 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.24 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.23 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.21 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.22 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.21 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.22 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.24 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.23 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.21 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.22 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.27 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.24 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.24 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.24 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.23 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.23 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.23 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.24 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.23 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.23 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.24 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.24 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.23 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.25 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.23 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.21 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.24 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.15 rifampicin
rpoA 3878875 c.-368C>T upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.18 rifampicin
rpoA 3878908 c.-402_-401delACinsCG upstream_gene_variant 0.18 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878924 c.-417G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.21 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878956 c.-449G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878968 c.-461T>G upstream_gene_variant 0.21 rifampicin
rpoA 3878976 c.-469A>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.24 rifampicin
rpoA 3879012 c.-505C>T upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.28 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.28 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.28 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.31 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.29 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.31 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.35 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.37 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.4 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.24 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.23 rifampicin
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038462 p.Ala748Glu missense_variant 0.15 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.19 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.18 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.23 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.22 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.22 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038851 c.1854G>A synonymous_variant 0.27 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.34 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.36 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.33 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.16 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.22 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.21 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.22 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.24 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.26 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.19 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040215 p.Ser164Thr missense_variant 0.15 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040234 c.471C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.22 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040417 c.288G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040477 c.228G>A synonymous_variant 0.16 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.17 pyrazinamide
panD 4044748 c.-467G>A upstream_gene_variant 0.16 pyrazinamide
panD 4044749 c.-468G>A upstream_gene_variant 0.16 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.17 pyrazinamide
panD 4044781 c.-500C>T upstream_gene_variant 0.15 pyrazinamide
panD 4044857 c.-576G>A upstream_gene_variant 0.15 pyrazinamide
panD 4044896 c.-615T>G upstream_gene_variant 0.16 pyrazinamide
panD 4044902 c.-621G>C upstream_gene_variant 0.16 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 0.18 pyrazinamide
panD 4044923 c.-642A>G upstream_gene_variant 0.2 pyrazinamide
panD 4044928 c.-647G>T upstream_gene_variant 0.17 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.17 pyrazinamide
panD 4044936 c.-655A>T upstream_gene_variant 0.18 pyrazinamide
panD 4044954 c.-673C>T upstream_gene_variant 0.15 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138463 c.1293C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138472 c.1284G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138478 c.1278T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138490 c.1266G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138493 p.Gln421Glu missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138496 c.1260G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138502 c.1254T>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138511 c.1245C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138518 p.Glu413Ala missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138523 c.1233C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138535 c.1221T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138538 c.1218C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138541 c.1215C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138547 c.1209C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138571 c.1185C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138583 c.1173G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138586 c.1170C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138594 p.Asn388Asp missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138715 c.1041G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138747 c.1009C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240654 c.792C>T synonymous_variant 0.18 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.19 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.18 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.15 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.18 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.18 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.18 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.19 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.19 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.17 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.19 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.18 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.19 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.2 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.21 ethambutol
embC 4240919 c.1057_1059delCTCinsTTG synonymous_variant 0.21 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.21 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.21 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.2 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.2 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.2 ethambutol
embC 4240966 c.1104G>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.2 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.2 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.22 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.21 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.18 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.18 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 0.96 ethambutol Not assoc w R
embA 4245885 p.Asp885Asn missense_variant 0.15 ethambutol
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247464 c.951C>G synonymous_variant 0.17 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.19 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.21 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.19 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.22 ethambutol
embB 4247536 c.1023C>G synonymous_variant 0.2 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.21 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.19 ethambutol
embB 4247567 c.1054C>T synonymous_variant 0.19 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.18 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.19 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.19 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.22 ethambutol
embB 4247611 c.1098G>C synonymous_variant 0.23 ethambutol
embB 4247614 c.1101T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.17 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.17 ethambutol
embB 4247635 c.1122G>A synonymous_variant 0.17 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248127 c.1614G>C synonymous_variant 0.17 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.17 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.18 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.18 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.2 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.21 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.23 ethambutol
embB 4248298 c.1785C>T synonymous_variant 0.22 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.22 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.2 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.21 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.2 ethambutol
embB 4248346 c.1833G>C synonymous_variant 0.19 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.17 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.17 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.17 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Ala missense_variant 0.17 ethambutol
embB 4249444 c.2931T>C synonymous_variant 0.16 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.16 ethambutol
embB 4249456 c.2943G>C synonymous_variant 0.19 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.2 ethambutol
embB 4249483 c.2970C>G synonymous_variant 0.19 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.18 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.18 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.19 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.16 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.17 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.17 ethambutol Uncertain significance
embB 4249543 c.3030G>C synonymous_variant 0.17 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.16 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.15 ethambutol
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 0.97 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R