TB-Profiler result

Run: SRR1196494
Summary

Run ID: SRR1196494

Sample name:

Date: 2025-02-11T09:57:26.491777

Number of reads: 633340

Percentage reads mapped: 52.19

Median coverage: 13.0

Strain:

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.2.BCG M.bovis None 0.06
lineage4 Euro-American None 0.99
lineage4.4.1.1 Euro-American None 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.52 rifampicin Assoc w R
rpsL 781822 p.Lys88Arg missense_variant 0.62 streptomycin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance Mutation from literature
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.39 isoniazid
dnaA 42 c.42C>T synonymous_variant 0.41 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.43 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.43 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.43 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 0.4 isoniazid
dnaA 588 c.588A>C synonymous_variant 0.4 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.4 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.47 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.32 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.32 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.47 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.5 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.53 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.5 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.43 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.44 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.44 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.48 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.48 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.45 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.41 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.43 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.33 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.36 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.36 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.41 isoniazid
dnaA 1461 c.1461C>G synonymous_variant 0.4 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.3 isoniazid
gyrB 5824 c.585A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 5827 c.588G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 5849 c.610C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.36 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6144 p.His302Arg missense_variant 0.58 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6238 c.999G>A synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6362 c.-940T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.55 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7216 c.1977G>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7246 c.2007T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7252 c.-50G>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 7256 c.-46_-44delCTGinsTTA upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7763 c.462T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8121 c.820T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.4 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8372 c.1071G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCTA synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8891 c.1590G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.46 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9233 c.1932C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.62 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.73 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
mshA 575713 c.366G>A synonymous_variant 0.53 isoniazid
ethionamide
mshA 575719 c.372C>T synonymous_variant 0.53 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.4 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.4 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.4 isoniazid
ethionamide
mshA 575752 c.405G>C synonymous_variant 0.38 isoniazid
ethionamide
mshA 575809 c.462C>T synonymous_variant 0.5 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.46 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.5 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.5 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.54 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.56 isoniazid Not assoc w R - Interim
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.67 isoniazid
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.82 isoniazid
ethionamide
mshA 575887 c.540G>C synonymous_variant 0.82 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.82 isoniazid
ethionamide
mshA 575896 c.549G>C synonymous_variant 0.75 isoniazid
ethionamide
mshA 575908 c.561A>G synonymous_variant 0.64 isoniazid
ethionamide
mshA 575917 p.Asp190Glu missense_variant 0.6 isoniazid
ethionamide
ccsA 620340 c.450C>G synonymous_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>T synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620376 c.486G>C synonymous_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.35 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620424 c.534G>C synonymous_variant 0.39 kanamycin
capreomycin
amikacin
Rv0565c 657300 c.171C>G synonymous_variant 0.44 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.35 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.28 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.26 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.25 ethionamide
hadA 731774 c.-156T>C upstream_gene_variant 0.54 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.54 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.54 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.55 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.55 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.63 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.61 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.44 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.44 isoniazid
nusG 734078 c.-176C>G upstream_gene_variant 0.33 rifampicin Uncertain significance
nusG 734093 c.-161A>C upstream_gene_variant 0.33 rifampicin
nusG 734096 c.-158C>T upstream_gene_variant 0.33 rifampicin
nusG 734102 c.-152G>C upstream_gene_variant 0.33 rifampicin
nusG 734111 c.-143A>G upstream_gene_variant 0.35 rifampicin
nusG 734114 c.-140A>G upstream_gene_variant 0.35 rifampicin
nusG 734120 c.-134T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
nusG 734123 c.-131C>G upstream_gene_variant 0.36 rifampicin
nusG 734129 c.-125G>C upstream_gene_variant 0.38 rifampicin
nusG 734132 c.-122G>C upstream_gene_variant 0.36 rifampicin
nusG 734135 c.-119G>C upstream_gene_variant 0.38 rifampicin
nusG 734144 c.-110G>C upstream_gene_variant 0.43 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.43 rifampicin
nusG 734370 c.117A>G synonymous_variant 0.67 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.67 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.62 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.63 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.63 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.67 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.61 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.68 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.61 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.5 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.56 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.53 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.5 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.5 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.5 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.5 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.5 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.46 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.56 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.56 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.56 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.56 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.56 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.58 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.55 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.45 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.47 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.31 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.36 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.34 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.45 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.52 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.5 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.54 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.56 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.58 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.58 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.57 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.6 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.63 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760472 c.666C>T synonymous_variant 0.75 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.5 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.36 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.45 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.43 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760862 c.1056G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.45 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.5 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.5 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.52 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.55 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.58 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.65 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.53 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.45 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.75 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.68 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761750 c.1944G>C synonymous_variant 0.5 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.54 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.57 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.57 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.58 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.5 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.47 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.57 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.55 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.57 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.57 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.57 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.45 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.38 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.46 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.42 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.42 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.62 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.68 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.71 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.75 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.81 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.47 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.53 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.45 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.41 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.5 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.48 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.48 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.52 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.52 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.5 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.58 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.53 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.5 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.5 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.56 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.54 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.54 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.6 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.39 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.42 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.45 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.38 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.39 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.39 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.46 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.35 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.31 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.47 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.36 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.55 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.52 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.56 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.52 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.52 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.57 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.5 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763835 p.Ala156Met missense_variant 0.44 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.4 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.39 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.45 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.48 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.53 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.6 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.6 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.53 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.53 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.5 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.53 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.6 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.65 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.65 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.6 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.63 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.55 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.41 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.44 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.43 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.47 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.47 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.32 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764458 c.1089G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.56 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.42 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.38 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.4 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.77 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.7 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765364 c.1995G>A synonymous_variant 0.55 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.48 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.42 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.41 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.59 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.57 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.48 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.48 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.5 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.5 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.61 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.7 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.61 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.61 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.57 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.52 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.62 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.62 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.61 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.65 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.61 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.5 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.52 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.58 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.6 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.63 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.67 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.58 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766549 c.3180G>C synonymous_variant 0.53 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.5 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.62 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.57 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.64 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.6 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.59 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.59 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.52 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.56 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.56 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.69 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.71 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.67 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.47 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.61 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.69 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.47 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.67 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.58 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.5 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.6 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.48 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.48 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.58 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.55 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
mmpL5 776660 c.1821C>G synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 776672 c.1809G>C synonymous_variant 0.52 bedaquiline
clofazimine
mmpL5 776675 c.1806G>A synonymous_variant 0.48 bedaquiline
clofazimine
mmpL5 776684 c.1797G>A synonymous_variant 0.52 bedaquiline
clofazimine
mmpL5 776687 p.Trp598Phe missense_variant 0.5 bedaquiline
clofazimine
mmpL5 776695 p.Val596Ile missense_variant 0.48 bedaquiline
clofazimine
mmpL5 776738 c.1743C>T synonymous_variant 0.48 bedaquiline
clofazimine
mmpL5 776744 c.1735_1737delCGCinsAGA synonymous_variant 0.43 bedaquiline
clofazimine
mmpL5 777116 c.1365C>T synonymous_variant 0.41 bedaquiline
clofazimine
mmpL5 777133 p.Val450Ile missense_variant 0.45 bedaquiline
clofazimine
mmpL5 777158 c.1323C>G synonymous_variant 0.5 bedaquiline
clofazimine
mmpL5 777164 c.1317C>G synonymous_variant 0.48 bedaquiline
clofazimine
mmpL5 777170 c.1311T>C synonymous_variant 0.52 bedaquiline
clofazimine
mmpL5 777176 p.Glu435Asp missense_variant 0.52 bedaquiline
clofazimine
mmpL5 777191 c.1290C>G synonymous_variant 0.5 bedaquiline
clofazimine
mmpL5 777194 c.1287A>G synonymous_variant 0.47 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.53 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.65 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.73 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.69 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.57 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.57 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.6 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.6 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.43 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.36 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.38 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.45 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.45 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.45 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.39 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.41 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.35 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.37 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.44 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.4 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.38 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.47 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.47 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.47 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.5 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.46 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.43 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.5 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.6 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.6 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.69 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.67 streptomycin Uncertain significance
rplC 800537 c.-272C>T upstream_gene_variant 0.35 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.38 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.47 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.57 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.5 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.55 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.56 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.53 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.45 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.45 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.39 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.41 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.39 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.36 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.41 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.5 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.52 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.5 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.47 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.47 linezolid
rplC 800814 c.6A>G synonymous_variant 0.5 linezolid
rplC 800817 c.9A>T synonymous_variant 0.48 linezolid
rplC 800844 c.36T>C synonymous_variant 0.39 linezolid
rplC 800907 c.99C>G synonymous_variant 0.35 linezolid
rplC 800916 c.108A>G synonymous_variant 0.32 linezolid
rplC 801339 c.531T>C synonymous_variant 0.47 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.47 linezolid
rplC 801348 c.540T>G synonymous_variant 0.44 linezolid
rplC 801357 c.549T>C synonymous_variant 0.48 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.45 linezolid
fbiC 1303497 c.567G>A synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303501 c.571C>T synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303509 c.579G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303521 c.591C>T synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303530 c.600G>A synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303534 p.Ser202Ala missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303539 c.609G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304004 c.1074A>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304142 c.1212G>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304161 p.Arg411Ser missense_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304169 c.1239T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304174 p.Val415Ala missense_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304535 c.1605G>A synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304545 p.Val539Thr missense_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304553 c.1623C>T synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.63 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.58 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.63 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.63 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.63 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.67 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
atpE 1460816 c.-229T>C upstream_gene_variant 0.39 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.45 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.45 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.47 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.5 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.5 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.48 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.5 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.5 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.41 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.44 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.35 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474958 n.1301A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
inhA 1674537 c.336C>G synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.41 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674552 c.351C>G synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.44 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.48 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.55 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.5 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.5 isoniazid
ethionamide
inhA 1674601 p.Leu134Thr missense_variant 0.5 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.5 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.53 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674741 c.540C>T synonymous_variant 0.33 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.35 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674855 c.654C>G synonymous_variant 0.47 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674864 c.663C>T synonymous_variant 0.47 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.5 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.5 isoniazid
ethionamide
inhA 1674909 c.708G>A synonymous_variant 0.53 isoniazid
ethionamide
inhA 1674942 c.741T>G synonymous_variant 0.54 isoniazid
ethionamide
inhA 1674960 c.759C>G synonymous_variant 0.55 isoniazid
ethionamide
rpsA 1833532 c.-10A>C upstream_gene_variant 0.35 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.5 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.62 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.65 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.52 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.48 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.56 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.58 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.54 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.62 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.5 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.79 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.67 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.65 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.67 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.65 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834510 c.969C>T synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 0.69 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.69 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.74 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.7 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.46 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.48 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.48 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.36 pyrazinamide
tsnR 1853447 c.-159C>G upstream_gene_variant 0.62 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918224 c.285G>C synonymous_variant 0.5 capreomycin
tlyA 1918236 c.297A>C synonymous_variant 0.47 capreomycin
tlyA 1918248 c.309T>C synonymous_variant 0.39 capreomycin
tlyA 1918251 c.312T>G synonymous_variant 0.39 capreomycin
tlyA 1918258 p.His107Glu missense_variant 0.33 capreomycin
tlyA 1918271 p.Ala111Val missense_variant 0.35 capreomycin
tlyA 1918275 c.336T>C synonymous_variant 0.35 capreomycin
tlyA 1918278 c.339C>G synonymous_variant 0.35 capreomycin
bacA 2064972 c.-244T>C upstream_gene_variant 0.57 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.43 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101744 p.Asp433Glu missense_variant 0.43 isoniazid
delamanid
ethionamide
ndh 2101756 c.1287G>C synonymous_variant 0.47 isoniazid
delamanid
ethionamide
ndh 2101765 c.1278C>G synonymous_variant 0.44 isoniazid
delamanid
ethionamide
ndh 2101768 c.1275C>A synonymous_variant 0.47 isoniazid
delamanid
ethionamide
ndh 2101771 c.1272T>G synonymous_variant 0.47 isoniazid Not assoc w R - Interim
delamanid
ethionamide
ndh 2101774 c.1269T>C synonymous_variant 0.47 isoniazid
delamanid
ethionamide
ndh 2101777 c.1266C>G synonymous_variant 0.47 isoniazid Not assoc w R - Interim
delamanid
ethionamide Not assoc w R - Interim
ndh 2101783 c.1260T>A synonymous_variant 0.5 isoniazid
delamanid
ethionamide
ndh 2101804 c.1239T>G synonymous_variant 0.5 isoniazid
delamanid
ethionamide
ndh 2102990 p.Val18Ala missense_variant 1.0 isoniazid Not assoc w R
delamanid Uncertain significance
ethionamide Uncertain significance
katG 2155695 c.417C>G synonymous_variant 0.46 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.43 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.53 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.53 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.53 isoniazid
katG 2156117 c.-6A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2288937 p.Ala102Val missense_variant 1.0 pyrazinamide Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.57 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.4 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.38 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.38 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.44 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.42 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.39 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.43 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.67 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.69 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.69 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.68 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.65 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.62 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.62 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.62 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.62 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.65 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.47 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.47 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.5 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.47 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.4 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.39 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.38 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.38 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.5 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.39 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.38 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.62 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.59 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.35 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.35 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.33 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.36 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.3 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.3 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.32 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
folC 2747264 p.Gly112Ala missense_variant 0.6 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.7 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.67 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.67 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.67 para-aminosalicylic_acid
folC 2747302 c.297A>C synonymous_variant 0.64 para-aminosalicylic_acid
Rv2477c 2782453 c.1590C>G synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782894 c.1149C>G synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.36 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.45 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.45 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.62 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.57 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.52 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.52 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.56 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
ribD 2987066 c.228A>G synonymous_variant 0.39 para-aminosalicylic_acid
ribD 2987069 c.231T>C synonymous_variant 0.41 para-aminosalicylic_acid
ribD 2987092 p.Val85Ala missense_variant 0.47 para-aminosalicylic_acid
ribD 2987105 c.267C>G synonymous_variant 0.47 para-aminosalicylic_acid
ribD 2987108 c.270T>C synonymous_variant 0.47 para-aminosalicylic_acid
Rv2752c 3065040 c.1152C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065052 c.1140G>A synonymous_variant 0.4 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065055 c.1137T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3066024 c.168T>G synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066040 p.Gly51Thr missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066042 c.150T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066045 c.147T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066050 p.Leu48Met missense_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066054 c.138T>G synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066075 c.117A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066093 c.99T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066099 p.Met31Ile missense_variant 0.69 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067394 c.552G>C synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.75 para-aminosalicylic_acid
thyX 3067442 c.504C>T synonymous_variant 0.75 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.75 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.69 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.67 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.64 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.69 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.62 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.72 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.76 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.75 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.73 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.62 para-aminosalicylic_acid
thyX 3067877 c.69G>C synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.56 para-aminosalicylic_acid
ald 3086635 c.-185_-184insA upstream_gene_variant 1.0 cycloserine
Rv3083 3448608 c.105G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
whiB7 3569181 c.-502C>T upstream_gene_variant 0.38 kanamycin
amikacin
streptomycin
Rv3236c 3612665 p.Val151Ala missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625594 c.-684T>C upstream_gene_variant 0.53 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.56 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.56 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrB 3625633 c.981C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.53 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.65 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.59 rifampicin
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.57 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625777 c.-867C>G upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.45 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrA 3626846 c.504G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrA 3627056 c.294C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.65 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.55 rifampicin
bedaquiline
mtrA 3627146 c.204C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.48 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.6 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.61 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.61 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.63 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.63 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.68 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.65 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.61 rifampicin
bedaquiline
mtrA 3627872 c.-523T>C upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrA 3627875 c.-526G>C upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrA 3627881 c.-532G>C upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrA 3627884 c.-535A>G upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrA 3627887 c.-538C>G upstream_gene_variant 0.6 rifampicin
bedaquiline
mtrA 3627893 c.-544T>G upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrA 3627917 c.-568G>C upstream_gene_variant 0.59 rifampicin
bedaquiline
mtrA 3627920 c.-571A>G upstream_gene_variant 0.56 rifampicin
bedaquiline
fbiB 3642719 c.1185T>C synonymous_variant 0.6 pretomanid
delamanid
clofazimine
rpoA 3877507 p.Gly334Ala missense_variant 0.4 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.4 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.41 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.56 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.54 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.56 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.57 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.61 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.67 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.55 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.46 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.41 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.39 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.35 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.37 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.41 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.45 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.48 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.54 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.46 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.4 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.5 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.41 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.5 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.56 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.62 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.67 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.65 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.69 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.67 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.67 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.64 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.58 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.47 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.47 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.5 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.5 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.56 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.59 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.75 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.75 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.71 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.68 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.67 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.6 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.57 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.56 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.54 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.52 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.52 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.55 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.55 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.6 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.56 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.7 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.73 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.65 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.59 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.56 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.53 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.48 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.54 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.54 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.63 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.63 rifampicin
clpC1 4038456 p.Val750Glu missense_variant 0.45 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.45 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.41 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.41 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.41 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.45 pyrazinamide
clpC1 4038530 c.2175G>A synonymous_variant 0.48 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.58 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.52 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.6 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.54 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.57 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.57 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.48 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.48 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.52 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.54 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.64 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.7 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.71 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.67 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.67 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.64 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.57 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.59 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.68 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.89 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.89 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.82 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.62 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.64 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.47 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.5 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.35 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039718 c.987C>A synonymous_variant 0.33 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.53 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.57 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.4 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.4 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.44 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.53 pyrazinamide
clpC1 4040321 c.384C>T synonymous_variant 0.5 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.44 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.5 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.29 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.27 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040695 c.10C>A synonymous_variant 0.3 pyrazinamide
clpC1 4040699 c.6C>T synonymous_variant 0.3 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.5 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.53 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.56 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.53 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.56 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.69 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.65 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.67 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.63 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.61 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.56 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.56 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.56 pyrazinamide
glpK 4138718 c.1038T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139165 c.591A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139168 c.588T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139177 c.579T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139183 c.573T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139186 c.570G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.59 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.62 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.62 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.5 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.56 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.59 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.45 ethambutol Not assoc w R - Interim
embC 4241488 c.1626G>C synonymous_variant 0.43 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.39 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.48 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.5 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.48 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.52 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.5 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.48 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.52 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.5 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.45 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.47 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.39 ethambutol
embA 4242742 c.-491C>G upstream_gene_variant 0.57 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.56 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.53 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.54 ethambutol
embA 4242772 c.-461G>C upstream_gene_variant 0.58 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.39 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.44 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.5 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.62 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.57 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.59 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.57 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.54 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.52 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.48 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.48 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.48 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.42 ethambutol
embA 4245693 p.Ile821Val missense_variant 0.56 ethambutol
embB 4245701 c.-813G>C upstream_gene_variant 0.53 ethambutol
embB 4245704 c.-810G>C upstream_gene_variant 0.5 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.5 ethambutol
embB 4245726 c.-788T>C upstream_gene_variant 0.5 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.52 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.52 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.53 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.5 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.41 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.67 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.64 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.53 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.71 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.63 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.62 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.9 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.85 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.91 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.91 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.54 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.54 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.62 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.57 ethambutol Not assoc w R - Interim
embB 4248130 c.1617G>C synonymous_variant 0.38 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.56 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.56 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.56 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.5 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.48 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.42 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.41 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.41 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.39 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.43 ethambutol
embB 4248382 c.1869C>G synonymous_variant 0.42 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.39 ethambutol
embB 4248407 p.Leu632Val missense_variant 0.29 ethambutol
embB 4248410 p.Phe633Leu missense_variant 0.27 ethambutol
embB 4248419 p.Leu636Met missense_variant 0.29 ethambutol
embB 4248425 c.1912T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248430 c.1917T>C synonymous_variant 0.29 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.29 ethambutol
embB 4248457 c.1944T>C synonymous_variant 0.36 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.5 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.46 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.46 ethambutol Not assoc w R - Interim
aftB 4268994 c.-158T>G upstream_gene_variant 0.43 ethambutol
ubiA 4268999 c.835C>T synonymous_variant 0.4 ethambutol Not assoc w R - Interim
aftB 4269006 c.-170T>C upstream_gene_variant 0.4 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.43 ethambutol
ubiA 4269027 c.807C>T synonymous_variant 0.44 ethambutol Not assoc w R - Interim
aftB 4269033 c.-197T>C upstream_gene_variant 0.41 ethambutol
aftB 4269036 c.-200C>G upstream_gene_variant 0.41 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.39 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin