TB-Profiler result

Run: ERR176740
Summary

Run ID: ERR176740

Sample name:

Date: 2025-02-11T19:23:47.575879

Number of reads: 225871

Percentage reads mapped: 5.29

Median coverage: 3.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.06
lineage4.3.4.2.1 Euro-American (LAM) RD174 0.15
lineage4.9 Euro-American (H37Rv-like) None 0.84
lineage4.3.4.2 Euro-American (LAM) RD174 0.16
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Ala356Val Uncertain significance Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247580 p.Ala356Val missense_variant 0.6 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 756 c.756T>C synonymous_variant 0.62 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.67 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.71 isoniazid
dnaA 792 c.792C>T synonymous_variant 0.71 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.74 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCTT synonymous_variant 0.71 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.64 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.69 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.75 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.75 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.82 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.82 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.82 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.82 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.82 isoniazid Not assoc w R - Interim
dnaA 876 c.876C>G synonymous_variant 0.75 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.67 isoniazid
dnaA 891 c.891C>T synonymous_variant 0.6 isoniazid Not assoc w R - Interim
dnaA 1008 c.1008G>A synonymous_variant 0.8 isoniazid Not assoc w R - Interim
dnaA 1020 c.1020C>G synonymous_variant 0.79 isoniazid
dnaA 1023 c.1023C>T synonymous_variant 0.79 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.79 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.78 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.75 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.9 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.91 isoniazid
dnaA 1200 c.1200C>G synonymous_variant 0.82 isoniazid
dnaA 1203 c.1203T>C synonymous_variant 0.85 isoniazid
dnaA 1215 c.1215C>T synonymous_variant 0.88 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.94 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.95 isoniazid
dnaA 1254 c.1254T>C synonymous_variant 0.95 isoniazid
dnaA 1263 c.1263C>G synonymous_variant 0.95 isoniazid
dnaA 1266 c.1266A>G synonymous_variant 0.95 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.9 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.88 isoniazid
dnaA 1293 c.1293T>G synonymous_variant 0.81 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.81 isoniazid Not assoc w R - Interim
dnaA 1302 c.1302C>G synonymous_variant 0.79 isoniazid
dnaA 1311 c.1311C>T synonymous_variant 0.73 isoniazid Not assoc w R - Interim
dnaA 1428 c.1428C>G synonymous_variant 0.75 isoniazid
dnaA 1434 c.1434C>A synonymous_variant 0.69 isoniazid
dnaA 1437 c.1437G>A synonymous_variant 0.69 isoniazid
dnaA 1441 c.1441C>T synonymous_variant 0.69 isoniazid
dnaA 1446 c.1446C>G synonymous_variant 0.69 isoniazid Not assoc w R - Interim
dnaA 1461 c.1461C>A synonymous_variant 0.69 isoniazid
dnaA 1467 c.1467G>A synonymous_variant 0.64 isoniazid Not assoc w R - Interim
dnaA 1473 c.1473T>C synonymous_variant 0.64 isoniazid Not assoc w R - Interim
gyrB 6115 c.876A>G synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.67 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6674 c.-628_-626delCTTinsTTG upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6733 c.-569G>A upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 6769 c.-533C>T upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7090 c.-212C>T upstream_gene_variant 0.91 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 7153 c.-149G>T upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrB 7156 c.1917C>T synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7174 c.-128C>T upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7502 c.201C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7526 c.225G>T synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 7725 c.424C>T synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7769 c.468C>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7797 c.496_498delCTAinsTTG synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7820 c.519G>C synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8543 c.1242C>T synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8585 c.1284C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8998 p.Leu566Trp missense_variant 0.73 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9003 c.1702C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>A synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.6 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
fgd1 490983 c.201G>A synonymous_variant 0.8 pretomanid
delamanid
clofazimine
ccsA 620343 c.453G>C synonymous_variant 0.73 kanamycin
capreomycin
amikacin
ccsA 620349 c.459A>T synonymous_variant 0.73 kanamycin
capreomycin
amikacin
ccsA 620712 c.822G>C synonymous_variant 0.73 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>A synonymous_variant 0.75 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.75 kanamycin
capreomycin
amikacin
hadA 731774 c.-156T>C upstream_gene_variant 0.7 isoniazid
hadA 731786 c.-144C>G upstream_gene_variant 0.7 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.7 isoniazid
hadA 731807 c.-123C>T upstream_gene_variant 0.58 isoniazid
hadA 731819 c.-111G>C upstream_gene_variant 0.55 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.92 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.92 isoniazid
nusG 734472 c.219T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 1.0 rifampicin
nusG 734520 c.267C>A synonymous_variant 0.9 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.73 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.67 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.62 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.9 rifampicin
rpoB 760145 c.339C>G synonymous_variant 0.82 rifampicin
rpoB 760181 c.375T>A synonymous_variant 0.85 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.82 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.8 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.7 rifampicin
rpoB 760358 c.552C>G synonymous_variant 0.77 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.77 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.75 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.75 rifampicin
rpoB 760412 c.606C>T synonymous_variant 0.64 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.92 rifampicin
rpoB 761333 c.1527G>C synonymous_variant 0.82 rifampicin
rpoB 761345 c.1539G>T synonymous_variant 0.75 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.75 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.83 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.82 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.82 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 1.0 rifampicin
rpoB 761558 c.1752C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761885 c.2079T>C synonymous_variant 1.0 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 1.0 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.9 rifampicin
rpoB 761912 c.2106T>G synonymous_variant 0.9 rifampicin
rpoB 761913 p.Asp703Gln missense_variant 0.9 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.9 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.91 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.92 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.92 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.82 rifampicin Uncertain significance
rpoB 762266 c.2460T>C synonymous_variant 0.5 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.38 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.8 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.8 rifampicin Uncertain significance
rpoB 762929 c.3123G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>G upstream_gene_variant 0.71 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763409 c.40_42delCTTinsTTG synonymous_variant 0.75 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.75 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.73 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.88 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.73 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763663 c.294C>T synonymous_variant 0.64 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.6 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.64 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763726 c.357C>T synonymous_variant 0.75 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.8 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.9 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.9 rifampicin
rpoC 763771 c.402C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763807 c.438T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763858 c.489A>G synonymous_variant 0.64 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.67 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.69 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.71 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.71 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.69 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.69 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.88 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.81 rifampicin
rpoC 763951 c.582G>A synonymous_variant 0.8 rifampicin
rpoC 763963 c.594C>G synonymous_variant 0.92 rifampicin
rpoC 763967 p.Gly200Ser missense_variant 0.92 rifampicin
rpoC 763972 c.603C>T synonymous_variant 0.92 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.92 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.93 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.94 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.91 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 1.0 rifampicin
rpoC 764044 c.675T>G synonymous_variant 1.0 rifampicin
rpoC 764059 c.690G>T synonymous_variant 1.0 rifampicin
rpoC 764083 c.714A>G synonymous_variant 1.0 rifampicin
rpoC 764098 c.729A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764278 c.909A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764686 c.1317C>T synonymous_variant 0.86 rifampicin
rpoC 764696 c.1327C>T synonymous_variant 0.87 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.8 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.8 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764782 c.1413C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.78 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.75 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.75 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 1.0 rifampicin Uncertain significance
rpoC 765391 c.2022C>T synonymous_variant 1.0 rifampicin
rpoC 765406 c.2037G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765409 c.2040T>C synonymous_variant 1.0 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 1.0 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Ser missense_variant 1.0 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.91 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.92 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 1.0 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.87 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.95 rifampicin
rpoC 765622 p.Glu751Asp missense_variant 0.83 rifampicin
rpoC 765625 c.2256C>T synonymous_variant 0.86 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765670 c.2301C>T synonymous_variant 0.8 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.82 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.82 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.71 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.8 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 766393 c.3024C>G synonymous_variant 0.92 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.92 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.88 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.9 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.88 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.87 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.86 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.77 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.75 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.77 rifampicin
rpoC 766700 c.3331C>T synonymous_variant 0.73 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.82 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 1.0 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 766900 c.3531T>C synonymous_variant 0.9 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.9 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
mmpL5 775951 c.2530C>T synonymous_variant 0.73 bedaquiline
clofazimine
mmpL5 775961 c.2520C>G synonymous_variant 0.73 bedaquiline
clofazimine
mmpL5 775966 p.Ala839Ser missense_variant 0.82 bedaquiline
clofazimine
rpsL 781721 c.162C>T synonymous_variant 0.9 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.82 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.82 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.82 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.82 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.8 streptomycin
rpsL 781772 c.213C>G synonymous_variant 0.82 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.83 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.9 streptomycin
rplC 800516 c.-293G>T upstream_gene_variant 0.6 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.77 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.77 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.81 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.75 linezolid
rplC 800582 c.-227C>T upstream_gene_variant 0.75 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.8 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.81 linezolid
rplC 800621 c.-188G>A upstream_gene_variant 0.79 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.8 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.8 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.79 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 1.0 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 1.0 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.92 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 1.0 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.92 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.9 linezolid
fbiC 1303512 c.582T>C synonymous_variant 0.8 pretomanid
delamanid
clofazimine
fbiC 1303534 p.Ser202Ala missense_variant 0.83 pretomanid
delamanid
clofazimine
fbiC 1303538 p.Arg203Leu missense_variant 0.85 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.91 pretomanid
delamanid
clofazimine
fbiC 1303605 c.675C>G synonymous_variant 0.82 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.82 pretomanid
delamanid
clofazimine
fbiC 1303750 c.820_822delTTAinsCTG synonymous_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1303755 c.825T>C synonymous_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.75 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.75 pretomanid
delamanid
clofazimine
fbiC 1304574 c.1644C>G synonymous_variant 0.75 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.7 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>G synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304868 c.1938G>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304883 c.1953G>A synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304982 c.2052G>A synonymous_variant 0.8 pretomanid
delamanid
clofazimine
fbiC 1304991 c.2061G>C synonymous_variant 0.8 pretomanid
delamanid
clofazimine
sigE 1364889 c.477A>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
sigE 1364919 c.507T>C synonymous_variant 0.8 pyrazinamide
embR 1416310 c.1038G>C synonymous_variant 0.7 ethambutol
embR 1416313 c.1035A>G synonymous_variant 0.7 ethambutol
embR 1416316 c.1032C>G synonymous_variant 0.7 ethambutol
embR 1416330 p.Val340Ile missense_variant 0.67 ethambutol
embR 1416332 p.Tyr339Phe missense_variant 0.67 ethambutol
embR 1416335 p.Asn338Ser missense_variant 0.67 ethambutol
embR 1416343 c.1005G>C synonymous_variant 0.67 ethambutol
embR 1416364 c.984C>T synonymous_variant 0.73 ethambutol
atpE 1460807 c.-238C>T upstream_gene_variant 0.82 bedaquiline
atpE 1460816 c.-229T>C upstream_gene_variant 0.87 bedaquiline
atpE 1460828 c.-217C>T upstream_gene_variant 0.88 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.88 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.88 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.86 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.85 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.8 bedaquiline
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.78 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.62 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.57 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472128 n.283G>C non_coding_transcript_exon_variant 0.57 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472129 n.284G>A non_coding_transcript_exon_variant 0.57 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472138 n.293C>T non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472147 n.302G>A non_coding_transcript_exon_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472690 n.845C>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin
rrs 1472697 n.852T>G non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472700 n.855C>T non_coding_transcript_exon_variant 0.84 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472708 n.863T>A non_coding_transcript_exon_variant 0.9 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472803 n.958T>C non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472827 n.982G>A non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.69 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.64 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473131 n.1286G>C non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473147 n.1302G>C non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473150 n.1305T>G non_coding_transcript_exon_variant 0.74 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473161 n.1316A>C non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>G non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473201 n.1356_1357delACinsT non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473248 n.1403G>A non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473249 n.1404T>C non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.79 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473262 n.1417T>A non_coding_transcript_exon_variant 0.78 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473281 n.1436C>G non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1473282 n.1437C>G non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1473676 n.19G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473831 n.174G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1473918 n.261C>T non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1473943 n.286G>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324delGinsAT non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1473994 n.337C>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474011 n.354G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474018 n.361G>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474030 n.373G>A non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474089 n.432C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474100 n.443C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474110 n.453A>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474187 n.530T>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474228 n.571T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474265 n.608G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474268 n.611C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474641 n.984G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475027 n.1370G>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475028 n.1371G>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475401 n.1745delC non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475404 n.1747A>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475453 n.1796T>A non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475487 n.1830C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid Uncertain significance
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1475605 n.1948A>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475617 n.1960C>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475625 n.1968G>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475637 n.1980T>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1475783 n.2126T>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475866 n.2209T>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475869 n.2212C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475999 n.2342G>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>C non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476047 n.2390G>A non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476077 n.2420T>C non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476229 n.2572C>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476353 n.2696G>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.85 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476513 n.2856G>A non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1476535 n.2878_2883delGGAAACinsAGGGAA non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1476544 n.2887T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476545 n.2888C>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476565 n.2908G>A non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1476566 n.2909A>G non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476577 n.2920T>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476578 n.2921C>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476592 n.2935G>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476605 n.2948C>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476608 n.2951C>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476637 n.2980C>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476657 n.3000G>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
inhA 1674549 c.348G>C synonymous_variant 0.91 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.92 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.83 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.8 isoniazid
ethionamide
inhA 1674588 c.387G>A synonymous_variant 0.8 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.8 isoniazid
ethionamide
inhA 1674601 p.Leu134Val missense_variant 0.85 isoniazid
ethionamide
inhA 1674618 c.417C>T synonymous_variant 0.71 isoniazid
ethionamide
inhA 1674624 c.423A>T synonymous_variant 0.83 isoniazid
ethionamide
inhA 1674627 c.426T>C synonymous_variant 0.86 isoniazid
ethionamide
inhA 1674655 c.454_456delAGCinsTCG synonymous_variant 0.64 isoniazid
ethionamide
inhA 1674669 c.468G>C synonymous_variant 0.77 isoniazid
ethionamide
inhA 1674828 c.627G>A synonymous_variant 0.9 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.83 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.85 isoniazid
ethionamide
inhA 1674876 c.675C>G synonymous_variant 0.93 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.93 isoniazid
ethionamide
inhA 1674888 c.687C>T synonymous_variant 0.81 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.85 isoniazid
ethionamide
inhA 1674909 c.708G>C synonymous_variant 0.85 isoniazid
ethionamide
inhA 1674915 c.714C>G synonymous_variant 0.86 isoniazid
ethionamide
rpsA 1833613 c.72C>A synonymous_variant 1.0 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 1.0 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.82 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.81 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.74 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.76 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.67 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1833874 c.333T>C synonymous_variant 0.86 pyrazinamide
rpsA 1833895 c.354G>C synonymous_variant 0.71 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.76 pyrazinamide
rpsA 1833970 c.429G>A synonymous_variant 0.85 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.94 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.94 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.92 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.83 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.87 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.85 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.75 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.85 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.92 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.91 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.9 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.9 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834603 c.1062G>A synonymous_variant 1.0 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834633 c.1092A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 1.0 pyrazinamide
katG 2155632 c.480A>G synonymous_variant 0.8 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.8 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.8 isoniazid Uncertain significance
katG 2155656 c.456G>A synonymous_variant 0.8 isoniazid
katG 2155661 p.Val151Ile missense_variant 0.8 isoniazid
kasA 2517917 c.-198G>T upstream_gene_variant 0.86 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.82 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.85 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.87 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.8 isoniazid
kasA 2517983 c.-132T>C upstream_gene_variant 0.82 isoniazid
kasA 2517989 c.-126T>G upstream_gene_variant 0.8 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.85 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.71 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.64 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.92 isoniazid
kasA 2518840 c.726C>G synonymous_variant 0.9 isoniazid
Rv2477c 2783458 c.585G>C synonymous_variant 0.88 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.94 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.94 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.94 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.88 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.85 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.81 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.8 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783535 c.508C>T synonymous_variant 0.8 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>A synonymous_variant 0.77 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.83 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>C synonymous_variant 0.77 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.81 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783578 c.465G>A synonymous_variant 0.8 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783602 c.441G>A synonymous_variant 0.81 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.81 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783623 c.420G>A synonymous_variant 0.88 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.87 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783632 c.411C>G synonymous_variant 0.87 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.88 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.87 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.91 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.82 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783718 c.325T>C synonymous_variant 0.8 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.8 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.9 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.7 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2680 2996084 c.-21A>G upstream_gene_variant 0.8 capreomycin
Rv2680 2996109 p.Thr2Asn missense_variant 0.8 capreomycin
Rv2680 2996111 p.Ser3Arg missense_variant 0.8 capreomycin
Rv2752c 3065186 c.1006T>C synonymous_variant 0.9 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065199 c.993T>C synonymous_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065205 c.987T>C synonymous_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065210 c.982T>C synonymous_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066639 c.-448G>A upstream_gene_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066644 c.-453T>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066647 c.-456G>A upstream_gene_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066654 c.-463G>C upstream_gene_variant 0.82 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066676 c.-485C>T upstream_gene_variant 0.77 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066685 c.-495_-494delGGinsCC upstream_gene_variant 0.7 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066696 c.-505T>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyA 3073929 c.543T>C synonymous_variant 0.9 para-aminosalicylic_acid
thyA 3073944 c.528C>T synonymous_variant 0.92 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.91 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.91 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.91 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.91 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 1.0 para-aminosalicylic_acid
lpqB 3625663 c.-753G>C upstream_gene_variant 0.55 rifampicin
bedaquiline
lpqB 3625675 c.-765G>C upstream_gene_variant 0.69 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.73 rifampicin
bedaquiline
lpqB 3625690 c.-780T>G upstream_gene_variant 0.71 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.75 rifampicin
bedaquiline
mtrB 3625699 c.915C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625717 c.-807C>T upstream_gene_variant 0.71 rifampicin
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.88 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.85 rifampicin
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625783 c.-873C>T upstream_gene_variant 0.77 rifampicin
bedaquiline
lpqB 3625801 c.-891G>C upstream_gene_variant 0.75 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.92 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626407 c.207C>G synonymous_variant 1.0 rifampicin
bedaquiline
mtrA 3626825 c.525T>A synonymous_variant 0.9 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626885 c.-272A>G upstream_gene_variant 0.82 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.82 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.91 rifampicin
bedaquiline
mtrB 3626996 c.-383G>A upstream_gene_variant 0.92 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.91 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.91 rifampicin
bedaquiline
mtrB 3627017 c.-404G>A upstream_gene_variant 0.85 rifampicin
bedaquiline
mtrB 3627023 c.-410C>G upstream_gene_variant 0.86 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627101 c.-488C>G upstream_gene_variant 0.88 rifampicin
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.82 rifampicin
bedaquiline
mtrB 3627110 c.-497G>C upstream_gene_variant 0.83 rifampicin
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.89 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.88 rifampicin
bedaquiline
mtrB 3627137 c.-526_-524delTTGinsCTA upstream_gene_variant 0.85 rifampicin
bedaquiline
mtrB 3627143 c.-530G>C upstream_gene_variant 0.85 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.8 rifampicin
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.92 rifampicin
bedaquiline
mtrB 3627203 c.-590C>G upstream_gene_variant 0.92 rifampicin
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.92 rifampicin
bedaquiline
mtrB 3627212 c.-599C>T upstream_gene_variant 0.9 rifampicin
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.82 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.91 rifampicin
bedaquiline
mtrB 3627272 c.-659G>C upstream_gene_variant 0.92 rifampicin
bedaquiline
mtrB 3627278 c.-665G>T upstream_gene_variant 0.93 rifampicin
bedaquiline
mtrB 3627287 c.-674C>G upstream_gene_variant 0.9 rifampicin
bedaquiline
mtrB 3627296 c.-683T>G upstream_gene_variant 0.91 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTC upstream_gene_variant 0.83 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.86 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.86 rifampicin
bedaquiline
rpoA 3877557 c.951C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.73 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877758 c.750G>C synonymous_variant 0.7 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.83 rifampicin
rpoA 3877865 c.643C>T synonymous_variant 0.92 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.92 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>C synonymous_variant 0.92 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.91 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.9 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.9 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.9 rifampicin
rpoA 3878043 c.465G>C synonymous_variant 0.92 rifampicin
rpoA 3878046 c.462T>G synonymous_variant 0.86 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.8 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.8 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.8 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.79 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.85 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.92 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.92 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.86 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.92 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.92 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.92 rifampicin
rpoA 3878384 c.124C>T synonymous_variant 0.92 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.92 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.93 rifampicin
rpoA 3878418 c.90C>T synonymous_variant 0.92 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 1.0 rifampicin
clpC1 4038486 p.Gly740Asn missense_variant 0.92 pyrazinamide
clpC1 4038491 c.2214C>T synonymous_variant 0.92 pyrazinamide
clpC1 4038502 p.Ile735Val missense_variant 0.92 pyrazinamide
clpC1 4038508 c.2197C>T synonymous_variant 0.92 pyrazinamide
clpC1 4038518 c.2187G>T synonymous_variant 0.92 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 1.0 pyrazinamide
clpC1 4038537 p.Thr723Ser missense_variant 0.93 pyrazinamide
clpC1 4038539 c.2166G>C synonymous_variant 0.94 pyrazinamide
clpC1 4038569 c.2136C>T synonymous_variant 0.89 pyrazinamide
clpC1 4038575 c.2130C>G synonymous_variant 0.88 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.93 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.9 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.9 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.92 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.92 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4038773 c.1932T>C synonymous_variant 0.88 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.85 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038809 c.1896G>A synonymous_variant 0.83 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.82 pyrazinamide
clpC1 4038941 c.1764G>A synonymous_variant 0.77 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.77 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.77 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4039553 c.1152C>A synonymous_variant 0.92 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.92 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.91 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4039583 c.1122C>T synonymous_variant 0.92 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.93 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.95 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.94 pyrazinamide
clpC1 4039748 c.957G>A synonymous_variant 0.94 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.94 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.69 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.77 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039880 c.825G>A synonymous_variant 0.91 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040000 c.705C>T synonymous_variant 0.82 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.94 pyrazinamide
clpC1 4040030 c.675C>T synonymous_variant 0.88 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.94 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.94 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.83 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.92 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.9 pyrazinamide
clpC1 4040309 c.396C>T synonymous_variant 0.91 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.92 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.9 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.62 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4040662 c.43C>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4040669 c.36C>G synonymous_variant 0.62 pyrazinamide
clpC1 4040695 c.10C>A synonymous_variant 0.62 pyrazinamide
clpC1 4040711 c.-7G>A upstream_gene_variant 0.7 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.75 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.75 pyrazinamide
glpK 4138702 p.Gln352Glu missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138706 c.1050C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138715 c.1041G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138751 c.1005T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240759 c.897C>G synonymous_variant 0.8 ethambutol
embC 4240765 c.903C>G synonymous_variant 0.8 ethambutol
embC 4240813 p.Phe317Leu missense_variant 0.73 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.7 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.62 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.73 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.8 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.75 ethambutol
embB 4247550 p.Ala346Asp missense_variant 0.71 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.67 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.62 ethambutol
embB 4247572 c.1059A>C synonymous_variant 0.62 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.56 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.54 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.54 ethambutol
embB 4247638 c.1125G>C synonymous_variant 0.54 ethambutol
embB 4248190 c.1677G>C synonymous_variant 0.83 ethambutol Not assoc w R - Interim
embB 4248200 p.Ile563Val missense_variant 0.83 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.73 ethambutol Uncertain significance
embB 4248211 c.1698G>A synonymous_variant 0.67 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.75 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.78 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.75 ethambutol
embB 4248298 c.1785C>T synonymous_variant 0.79 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.79 ethambutol