TB-Profiler result

Run: ERR2514327
Summary

Run ID: ERR2514327

Sample name:

Date: 2024-04-15T06:38:01.632536

Number of reads: 2554990

Percentage reads mapped: 73.54

Median coverage: 72.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.98
lineage4.8 Euro-American (mainly T) RD219 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.604_606delTCGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1945_1947delATTinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303534 c.604_606delTCGinsGC frameshift_variant&missense_variant 0.17 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGT frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304875 c.1945_1947delATTinsGG frameshift_variant&missense_variant 0.28 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155168 p.Ser315Thr missense_variant 0.96 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 371 p.Pro124Leu missense_variant 1.0 isoniazid Not assoc w R
dnaA 741 c.741T>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.15 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.16 isoniazid
dnaA 1011 c.1011C>A synonymous_variant 0.14 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.18 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.19 isoniazid
dnaA 1116 c.1116C>G synonymous_variant 0.19 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.21 isoniazid
dnaA 1128 c.1128G>C synonymous_variant 0.22 isoniazid
dnaA 1149 c.1149C>G synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.19 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.19 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.19 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.2 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.21 isoniazid
dnaA 1179 c.1179G>C synonymous_variant 0.21 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.21 isoniazid
dnaA 1195 c.1195_1197delCTTinsTG frameshift_variant&missense_variant 0.21 isoniazid Uncertain significance
dnaA 1206 c.1206G>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7096 c.-206G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7198 c.1959C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7201 c.-101G>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7403 c.102C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7421 c.120G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7442 c.141G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7454 c.153G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7460 c.159C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7475 c.174A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7637 c.336C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7728 c.427A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8345 c.1044C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8354 c.1053G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8375 c.1074G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8447 c.1146C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8492 c.1191G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8537 c.1236G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8555 c.1254G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8562 c.1261C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8570 c.1269G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8666 c.1365G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8672 c.1371A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8706 c.1405C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8718 p.Glu473Lys missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8822 p.Asp507Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9176 c.1875G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9179 c.1878C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9192 c.1891C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9242 c.1941A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9303 p.Gly668Thr missense_variant 0.18 levofloxacin
moxifloxacin
fgd1 490830 c.48A>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490869 c.87C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491281 p.Asp167Pro missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491296 p.Val172Ile missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491310 c.528C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491316 c.534C>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
mshA 575734 c.387T>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.22 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.22 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.2 ethionamide
isoniazid Not assoc w R - Interim
mshA 575809 c.462C>T synonymous_variant 0.2 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575837 c.490C>T synonymous_variant 0.24 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575842 c.495G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.2 ethionamide
isoniazid
ccsA 619531 c.-360T>G upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGG upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 656976 p.Ala165Val missense_variant 0.16 ethionamide
Rv0565c 656985 c.486T>C synonymous_variant 0.17 ethionamide
Rv0565c 656989 p.Lys161Thr missense_variant 0.18 ethionamide
Rv0565c 657000 p.Gly157Ala missense_variant 0.16 ethionamide
Rv0565c 657006 p.Asp155Glu missense_variant 0.17 ethionamide Uncertain significance
Rv0565c 657032 p.Asn147Asp missense_variant 0.17 ethionamide
Rv0565c 657072 c.399C>T synonymous_variant 0.15 ethionamide
Rv0565c 657123 c.348A>G synonymous_variant 0.15 ethionamide
Rv0565c 657135 c.336G>C synonymous_variant 0.17 ethionamide
Rv0565c 657138 c.331_333delGCAinsTG frameshift_variant&missense_variant 0.18 ethionamide Uncertain significance
Rv0565c 657144 c.327T>C synonymous_variant 0.18 ethionamide
Rv0565c 657160 p.Glu104Arg missense_variant 0.18 ethionamide
Rv0565c 657165 c.306C>T synonymous_variant 0.17 ethionamide
Rv0565c 657193 p.Met93Thr missense_variant 0.17 ethionamide
Rv0565c 657196 p.Asp92Ala missense_variant 0.16 ethionamide
Rv0565c 657201 c.270C>G synonymous_variant 0.16 ethionamide
hadA 731747 c.-183T>C upstream_gene_variant 0.18 isoniazid
hadA 731753 c.-177A>C upstream_gene_variant 0.18 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.15 isoniazid
hadA 732373 c.444_447delGGATinsAAACGGA missense_variant&conservative_inframe_insertion 0.18 isoniazid
hadA 732378 p.Gly150Glu missense_variant 0.17 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.23 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.22 isoniazid
nusG 734120 c.-134T>C upstream_gene_variant 0.16 rifampicin Uncertain significance
nusG 734129 c.-125G>A upstream_gene_variant 0.19 rifampicin Uncertain significance
nusG 734143 c.-111C>T upstream_gene_variant 0.21 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.21 rifampicin
nusG 734173 c.-81C>G upstream_gene_variant 0.22 rifampicin
nusG 734177 c.-77T>C upstream_gene_variant 0.22 rifampicin
nusG 734180 c.-74T>G upstream_gene_variant 0.22 rifampicin Uncertain significance
nusG 734183 c.-71C>T upstream_gene_variant 0.22 rifampicin
nusG 734186 c.-68G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
nusG 734192 c.-62G>C upstream_gene_variant 0.22 rifampicin
nusG 734205 c.-49A>C upstream_gene_variant 0.18 rifampicin
nusG 734208 c.-46T>C upstream_gene_variant 0.18 rifampicin
nusG 734231 c.-22_-21delGT upstream_gene_variant 0.17 rifampicin
nusG 734236 c.-18C>T upstream_gene_variant 0.17 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.2 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.19 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.2 rifampicin
nusG 734448 c.195C>T synonymous_variant 0.19 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.2 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.19 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.19 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.18 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.18 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.16 rifampicin
nusG 734670 c.417G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.23 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.23 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.26 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760304 c.498G>A synonymous_variant 0.21 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.21 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.23 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.23 rifampicin
rpoB 760343 c.537G>C synonymous_variant 0.24 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.21 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.2 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.23 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.2 rifampicin
rpoB 760508 c.702G>C synonymous_variant 0.22 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.21 rifampicin
rpoB 760514 c.708C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.23 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243His missense_variant 0.19 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.21 rifampicin
rpoB 760598 c.792C>G synonymous_variant 0.21 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.25 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>G synonymous_variant 0.23 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.22 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760938 c.1132C>T synonymous_variant 0.31 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.28 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.22 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.22 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.23 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.25 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.29 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>C synonymous_variant 0.31 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.31 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.31 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.25 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761492 c.1686G>C synonymous_variant 0.16 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.17 rifampicin
rpoB 761531 c.1725C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.27 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.21 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.22 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.21 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.19 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.21 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.21 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.22 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.16 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.21 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.21 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.21 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.2 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.21 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 0.21 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.23 rifampicin
rpoB 761879 c.2073G>A synonymous_variant 0.23 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.24 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.23 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.21 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.21 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.21 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.21 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.21 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>A synonymous_variant 0.25 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.26 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 762140 c.2334G>C synonymous_variant 0.19 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.17 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>G synonymous_variant 0.21 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.23 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.2 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>G synonymous_variant 0.26 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.25 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.24 rifampicin
rpoB 762353 c.2547C>T synonymous_variant 0.25 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.23 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.25 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.21 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.17 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.17 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.19 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.19 rifampicin
rpoB 762489 p.Val895Gln missense_variant 0.23 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.24 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.24 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.21 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.2 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.2 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.19 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.16 rifampicin
rpoC 762728 c.-642C>G upstream_gene_variant 0.23 rifampicin
rpoB 762730 p.Gln975Arg missense_variant 0.24 rifampicin
rpoC 762749 c.-621C>G upstream_gene_variant 0.27 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.3 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.32 rifampicin
rpoB 762836 c.3030C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.26 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.34 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.29 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.24 rifampicin
rpoB 763184 c.3378C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763187 c.-183C>G upstream_gene_variant 0.22 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.23 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.25 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.27 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.31 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.22 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.16 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.17 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.18 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.18 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.22 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.24 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.27 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.23 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.24 rifampicin
rpoC 763835 p.Ala156Thr missense_variant 0.31 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.34 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.34 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.36 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.36 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.33 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.33 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.29 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.22 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.3 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.35 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.36 rifampicin
rpoC 764195 p.Ser276Met missense_variant 0.36 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764255 c.886C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>C synonymous_variant 0.22 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.21 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.2 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764359 c.990C>G synonymous_variant 0.27 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.19 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.19 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.21 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.21 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>G synonymous_variant 0.2 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.21 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.21 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.26 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.21 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.21 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.25 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.23 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>A synonymous_variant 0.22 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.2 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.2 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764842 c.1473C>T synonymous_variant 0.23 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.18 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.2 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.19 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.24 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764939 c.1570C>T synonymous_variant 0.25 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>A synonymous_variant 0.21 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>G synonymous_variant 0.23 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>T synonymous_variant 0.22 rifampicin
rpoC 765367 c.1998C>G synonymous_variant 0.21 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.23 rifampicin Uncertain significance
rpoC 765405 p.Leu679His missense_variant 0.23 rifampicin Uncertain significance
rpoC 765409 c.2040T>C synonymous_variant 0.23 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.23 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765550 c.2181C>T synonymous_variant 0.2 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.2 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.2 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.25 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.26 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.21 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.2 rifampicin
rpoC 765655 c.2286T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765712 c.2343C>G synonymous_variant 0.17 rifampicin
rpoC 765752 p.Asp795Ser missense_variant 0.18 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.26 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.27 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.27 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.27 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.25 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.24 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.24 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.23 rifampicin
rpoC 765986 c.2617C>T synonymous_variant 0.23 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.19 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.22 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.25 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.23 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.2 rifampicin
rpoC 766083 p.Ala905Glu missense_variant 0.15 rifampicin
rpoC 766085 p.Pro906Ala missense_variant 1.0 rifampicin Not assoc w R
rpoC 766327 c.2958C>A synonymous_variant 0.15 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.17 rifampicin
rpoC 766357 c.2988C>T synonymous_variant 0.16 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.16 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.16 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.19 rifampicin
rpoC 766429 c.3060C>G synonymous_variant 0.19 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.18 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.19 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.24 rifampicin
rpoC 766486 c.3117A>C synonymous_variant 0.25 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.28 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.25 rifampicin
rpoC 766528 c.3159T>A synonymous_variant 0.24 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.22 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.22 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.22 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.22 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.26 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.19 rifampicin
rpoC 766624 c.3255G>T synonymous_variant 0.18 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.19 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.21 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.22 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.26 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.27 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.27 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.24 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.23 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.23 rifampicin
rpoC 766780 c.3411G>A synonymous_variant 0.23 rifampicin
rpoC 766798 c.3429C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.25 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.31 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.23 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.19 rifampicin
rpoC 766981 c.3612T>G synonymous_variant 0.2 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.21 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.19 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.31 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767181 p.Ala1271Glu missense_variant 0.15 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775949 c.2532G>T synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.16 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.15 clofazimine
bedaquiline
mmpL5 776002 p.Leu827Met missense_variant 0.14 clofazimine
bedaquiline
mmpL5 776030 c.2451G>T synonymous_variant 0.14 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.16 streptomycin
rpsL 781664 c.105C>T synonymous_variant 0.15 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.2 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.2 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.2 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.2 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.21 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.21 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.2 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.2 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.23 streptomycin
rpsL 781817 c.258G>A synonymous_variant 0.24 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.25 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 0.27 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.27 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.26 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.27 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.26 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.25 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.23 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.24 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.25 streptomycin Uncertain significance
rplC 800600 c.-209G>T upstream_gene_variant 0.14 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.18 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.18 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.18 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.17 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.15 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.15 linezolid
fbiC 1303542 c.612C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Thr missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303746 p.Asp272Glu missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304496 c.1566T>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304499 c.1569T>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304502 c.1572G>A synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304516 p.Ala529Val missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304532 c.1602G>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304607 c.1677C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304841 c.1911G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304865 c.1935C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304871 c.1941G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304931 c.2001C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
sigE 1364898 c.486C>T synonymous_variant 0.2 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.18 pyrazinamide
atpE 1460992 c.-53A>C upstream_gene_variant 1.0 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474018 n.361G>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.36 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
inhA 1674231 c.30T>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674570 c.369G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.22 ethionamide
isoniazid
inhA 1674601 c.400C>T synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674618 c.417C>T synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.19 ethionamide
isoniazid
rpsA 1833589 c.48A>T synonymous_variant 0.16 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833610 c.69C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833661 c.120A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.35 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1833771 p.Asn77Ser missense_variant 0.37 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833838 c.297G>A synonymous_variant 0.34 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833904 p.Glu121Asp missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.29 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>G synonymous_variant 0.2 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834792 c.1251G>T synonymous_variant 0.17 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.15 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.17 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.17 linezolid
tsnR 1853387 c.-219T>C upstream_gene_variant 0.16 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.2 linezolid
tsnR 1853429 c.-177G>T upstream_gene_variant 0.17 linezolid
tsnR 1853430 c.-176C>T upstream_gene_variant 0.17 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.18 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.18 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.18 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.18 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2155632 c.480A>C synonymous_variant 0.18 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.2 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.22 isoniazid Uncertain significance
katG 2155680 c.432G>C synonymous_variant 0.2 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.21 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.2 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.2 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.29 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.24 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.22 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.23 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.19 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.14 isoniazid
kasA 2518219 c.105T>A synonymous_variant 0.17 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.16 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.21 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.24 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.18 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.19 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.24 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.25 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.33 isoniazid
kasA 2518594 c.480C>G synonymous_variant 0.33 isoniazid
kasA 2518597 c.483C>T synonymous_variant 0.33 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.3 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.25 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.27 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.24 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.3 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.28 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.26 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.21 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.25 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.25 isoniazid
kasA 2518714 c.600A>T synonymous_variant 0.26 isoniazid
kasA 2518765 c.651G>C synonymous_variant 0.28 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.28 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.24 isoniazid
kasA 2518786 c.672G>A synonymous_variant 0.23 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.23 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.22 isoniazid
kasA 2518796 c.682C>A synonymous_variant 0.21 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.15 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.16 isoniazid
folC 2746333 c.1266C>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746351 c.1246_1248delGCCinsTG frameshift_variant&missense_variant 0.19 para-aminosalicylic_acid
folC 2746360 c.1239T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2746366 c.1233G>A synonymous_variant 0.21 para-aminosalicylic_acid
folC 2746393 c.1206C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2746402 c.1197T>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746405 p.Phe398Leu missense_variant 0.17 para-aminosalicylic_acid
folC 2747433 c.166C>T synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747443 c.156G>A synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747454 c.145C>A synonymous_variant 0.15 para-aminosalicylic_acid
Rv2477c 2783020 c.1023G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783080 c.963G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.949_951delCTAinsTG frameshift_variant&synonymous_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783095 c.948C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783104 c.939C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783218 c.825C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ile missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783247 c.796T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783281 c.762G>A synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783284 c.759G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783287 c.754_756delCTCinsTG frameshift_variant&synonymous_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783290 c.753G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 c.87T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859693 c.726C>T synonymous_variant 1.0 clofazimine
bedaquiline
Rv2752c 3065979 c.213T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065988 c.204A>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066002 p.Met64Leu missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066009 c.183G>T synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066012 c.180C>A synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066071 c.121T>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066081 c.111G>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066731 c.-540G>A upstream_gene_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067304 c.642A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067340 c.606G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067364 c.582C>T synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067676 c.270C>A synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067680 p.Cys89Phe missense_variant 0.14 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067691 c.255C>T synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067715 p.Ser77Asn missense_variant 0.17 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067733 c.213G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067745 c.201C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.18 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.18 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067796 c.150C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073845 c.627C>T synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073874 p.Ile200Val missense_variant 0.22 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073881 c.591C>T synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073947 c.525G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073995 c.477G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074007 c.465C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.16 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.16 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074064 c.408C>G synonymous_variant 0.19 para-aminosalicylic_acid
ald 3087714 p.Ala299Ser missense_variant 0.16 cycloserine
ald 3087726 p.Ala303Thr missense_variant 0.15 cycloserine
ald 3087750 p.Tyr311Val missense_variant 0.18 cycloserine
ald 3087779 c.960T>C synonymous_variant 0.2 cycloserine
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
lpqB 3623468 c.1443T>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623492 c.1419T>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624416 c.495G>A synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624656 c.255C>T synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624680 c.231T>A synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.23 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>G synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.2 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
lpqB 3625672 c.-762G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625675 c.-765G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.19 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625774 c.840G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626798 c.-185T>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626840 c.-227C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626915 c.-302C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627008 c.-395G>A upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627074 c.-461G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627101 c.-488C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627104 c.-491C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627119 c.-506T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627122 c.-509T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627125 c.-512C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627263 c.-650C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627277 c.73C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627296 c.-683T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
fbiB 3641235 c.-300G>C upstream_gene_variant 0.18 clofazimine
pretomanid
delamanid
fbiB 3641244 c.-291G>C upstream_gene_variant 0.18 clofazimine
pretomanid
delamanid
fbiA 3641245 p.Glu235Ser missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiB 3641250 c.-285A>G upstream_gene_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3641256 c.-279A>C upstream_gene_variant 0.2 clofazimine
pretomanid
delamanid
alr 3840764 c.657G>C synonymous_variant 1.0 cycloserine
rpoA 3877613 p.Ile299Val missense_variant 0.21 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.2 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.19 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.2 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.16 rifampicin
rpoA 3877740 c.768G>T synonymous_variant 0.23 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.2 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877797 c.711G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.23 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.2 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877899 p.Ser203Thr missense_variant 0.19 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.16 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.16 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.2 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.2 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.21 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.22 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.22 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.22 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.23 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.21 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878256 c.252G>C synonymous_variant 0.16 rifampicin
rpoA 3878262 c.244_246delAGCinsGA frameshift_variant&missense_variant 0.16 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.17 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878309 p.Pro67Ala missense_variant 0.15 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.15 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>C synonymous_variant 0.25 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.28 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.27 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.26 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.21 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.2 rifampicin
rpoA 3878430 c.78G>C synonymous_variant 0.19 rifampicin
rpoA 3878433 c.75G>C synonymous_variant 0.19 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.2 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.19 rifampicin
rpoA 3878451 c.57C>G synonymous_variant 0.2 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.2 rifampicin
rpoA 3878469 c.39C>G synonymous_variant 0.2 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.19 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.18 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.15 rifampicin
rpoA 3878800 c.-293G>A upstream_gene_variant 0.43 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.44 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.44 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.4 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.38 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.34 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.27 rifampicin
rpoA 3878908 c.-402_-401delACinsGT upstream_gene_variant 0.2 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878950 c.-443C>G upstream_gene_variant 0.28 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878959 c.-452G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878989 c.-482G>A upstream_gene_variant 0.18 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3879007 c.-500G>C upstream_gene_variant 0.18 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.16 rifampicin
rpoA 3879022 c.-515G>A upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3879040 c.-535_-533delGTGinsACC upstream_gene_variant 0.17 rifampicin
rpoA 3879043 c.-536C>A upstream_gene_variant 0.17 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.17 rifampicin
rpoA 3879117 c.-610C>T upstream_gene_variant 0.15 rifampicin
rpoA 3879121 c.-615_-614delTTinsAG upstream_gene_variant 0.17 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.17 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.27 delamanid
pretomanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.22 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.19 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.17 delamanid
pretomanid
clpC1 4038433 c.2272C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.15 pyrazinamide
clpC1 4038461 c.2244G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038470 c.2235G>A synonymous_variant 0.16 pyrazinamide
clpC1 4038475 p.Ser744Gly missense_variant 0.15 pyrazinamide
clpC1 4038486 p.Gly740Thr missense_variant 0.18 pyrazinamide
clpC1 4038497 c.2208C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.21 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.22 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.33 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039031 c.1674T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039541 c.1164C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.25 pyrazinamide Uncertain significance
clpC1 4039574 c.1129_1131delGCGinsTC frameshift_variant&missense_variant 0.26 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039601 c.1104G>A synonymous_variant 0.25 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.19 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.17 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.17 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039957 c.748C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.19 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040027 c.678C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.22 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040096 c.609G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040108 c.597G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040126 c.579C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040129 c.576C>T synonymous_variant 0.18 pyrazinamide
panD 4044650 c.-369G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044656 c.-375G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044677 c.-396T>C upstream_gene_variant 0.29 pyrazinamide
panD 4044685 c.-404A>G upstream_gene_variant 0.26 pyrazinamide
panD 4044686 c.-407_-405delTTCinsCG upstream_gene_variant 0.26 pyrazinamide
panD 4044692 c.-411G>C upstream_gene_variant 0.26 pyrazinamide
panD 4044700 c.-419C>A upstream_gene_variant 0.3 pyrazinamide
panD 4044719 c.-438G>A upstream_gene_variant 0.35 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.31 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.31 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.29 pyrazinamide
panD 4044755 c.-474G>A upstream_gene_variant 0.29 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.2 pyrazinamide
panD 4044785 c.-504C>G upstream_gene_variant 0.2 pyrazinamide
panD 4044812 c.-531A>G upstream_gene_variant 0.16 pyrazinamide
glpK 4138364 c.1392G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138377 p.Val460Ala missense_variant 0.16 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138394 c.1362G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138451 c.1305T>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138464 p.Gly431Ala missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138472 c.1284G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138495 p.Gln421Glu missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138496 c.1260G>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138562 c.1194G>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138628 c.1128T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138655 c.1101G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138682 c.1074C>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138696 p.Pro354Ala missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138747 c.1009C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139126 c.630G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139131 p.Glu209Gln missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139132 c.624A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139135 c.621T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139143 c.613T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139194 p.Pro188Ala missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4241050 c.1188T>G synonymous_variant 0.17 ethambutol
embC 4241053 c.1191G>T synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.2 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.21 ethambutol
embA 4245158 c.1926C>G synonymous_variant 0.21 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.22 ethambutol
embA 4245183 c.1951C>T synonymous_variant 0.22 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.19 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.15 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.16 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.17 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.17 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.19 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.18 ethambutol
embB 4247528 c.1015C>T synonymous_variant 0.17 ethambutol
embB 4247608 c.1095G>C synonymous_variant 0.16 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247899 p.Met462Ile missense_variant 0.17 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.18 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247951 p.Ser480Ala missense_variant 0.16 ethambutol
embB 4247974 c.1461C>G synonymous_variant 0.16 ethambutol
embB 4248001 c.1488C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.16 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.15 ethambutol Uncertain significance
embB 4248199 c.1686A>G synonymous_variant 0.18 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.18 ethambutol
embB 4248206 c.1693_1695delAGCinsGA frameshift_variant&missense_variant 0.18 ethambutol
embB 4248211 c.1698G>T synonymous_variant 0.18 ethambutol
embB 4248233 c.1720C>T synonymous_variant 0.19 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.16 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.18 ethambutol
embB 4249487 c.2974_2976delTTGinsCC frameshift_variant&missense_variant 0.17 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
gid 4408102 p.Gly34Glu missense_variant 1.0 streptomycin Uncertain significance