TB-Profiler result

Run: ERR3797065
Summary

Run ID: ERR3797065

Sample name:

Date: 2024-10-04T16:23:49.012309

Number of reads: 122831

Percentage reads mapped: 5.55

Median coverage: 0.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.99
lineage4.9 Euro-American (H37Rv-like) None 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asn437Thr Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Asn437Thr Mutation from literature
p.Ser441Ala Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761116 p.Asn437Thr missense_variant 0.54 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rifampicin Mutation from literature
rpoB 761127 p.Ser441Ala missense_variant 0.41 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6673 c.-629A>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7442 c.141G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7517 c.216G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7520 c.219G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 1.0 rifampicin
rpoB 760931 c.1125C>G synonymous_variant 0.73 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760953 p.Ile383Val missense_variant 0.72 rifampicin
rpoB 760956 c.1150C>A synonymous_variant 0.72 rifampicin
rpoB 760959 p.Val385Leu missense_variant 0.72 rifampicin
rpoB 760965 p.Met387Leu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760968 p.Ser388Ala missense_variant 0.72 rifampicin
rpoB 760973 c.1167G>C synonymous_variant 1.0 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 1.0 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.56 rifampicin
rpoB 761024 c.1218C>A synonymous_variant 0.56 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231_1233delTTGinsCTC synonymous_variant 1.0 rifampicin
rpoB 761051 c.1245G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761064 p.Ala420Ser missense_variant 0.52 rifampicin Uncertain significance
rpoB 761084 c.1278C>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.48 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 1.0 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 1.0 rifampicin
rpoB 761123 c.1317G>C synonymous_variant 0.52 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761138 c.1332C>G synonymous_variant 0.39 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761156 c.1350G>C synonymous_variant 0.43 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 1.0 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.93 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.93 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.93 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.57 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.9 rifampicin
rpoB 761681 c.1875G>A synonymous_variant 0.64 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.62 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.92 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.62 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.62 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.64 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 1.0 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 1.0 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.64 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 1.0 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.62 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.53 rifampicin
rpoB 761990 c.2184G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.4 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.4 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.6 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762015 p.Glu737Gln missense_variant 0.58 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.58 rifampicin
rpoB 762026 c.2220G>C synonymous_variant 0.63 rifampicin
rpoB 762030 p.Thr742Ser missense_variant 0.59 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.48 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762084 p.Ala760Pro missense_variant 0.44 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.96 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.93 rifampicin
rpoB 762128 c.2322G>C synonymous_variant 0.42 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.96 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.95 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.95 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.95 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.71 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>T synonymous_variant 0.77 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.8 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.82 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 1.0 rifampicin Uncertain significance
rpoC 762896 c.-474G>C upstream_gene_variant 0.91 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.85 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763034 c.-336C>T upstream_gene_variant 0.82 rifampicin
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 1.0 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 1.0 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 1.0 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 1.0 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>G synonymous_variant 0.38 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.41 rifampicin
rpoC 763528 c.159G>T synonymous_variant 1.0 rifampicin
rpoC 763531 c.162G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763534 c.165T>C synonymous_variant 0.52 rifampicin
rpoC 763537 c.168C>T synonymous_variant 0.5 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.47 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.4 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.41 rifampicin
rpoC 763702 c.333C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.6 rifampicin
rpoC 763708 c.339G>C synonymous_variant 1.0 rifampicin
rpoC 763709 p.Leu114Phe missense_variant 0.4 rifampicin
rpoC 763714 c.345G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 1.0 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763891 c.522G>C synonymous_variant 0.9 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.9 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763903 c.534G>A synonymous_variant 0.9 rifampicin
rpoC 763925 p.Ala186Arg missense_variant 0.9 rifampicin
rpoC 763930 p.Glu187Asp missense_variant 0.9 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.9 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.92 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764395 c.1026C>T synonymous_variant 0.52 rifampicin
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.97 rifampicin
rpoC 764419 c.1050C>G synonymous_variant 0.48 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.97 rifampicin
rpoC 764441 p.Ile358Leu missense_variant 0.52 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.52 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.97 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>T synonymous_variant 0.28 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.69 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.68 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.6 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.35 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.63 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.65 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.3 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 1.0 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.59 rifampicin
rpoC 764706 p.Leu446Gln missense_variant 0.55 rifampicin Uncertain significance
rpoC 764713 c.1344G>A synonymous_variant 0.47 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764719 c.1350G>A synonymous_variant 0.45 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.53 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.33 rifampicin
rpoC 764800 c.1431G>A synonymous_variant 0.72 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.71 rifampicin Not assoc w R
rpoC 764827 c.1458G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.91 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 1.0 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>T synonymous_variant 1.0 rifampicin
rpoC 767173 c.3804C>A synonymous_variant 1.0 rifampicin
rpoC 767174 p.Asn1269His missense_variant 1.0 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 1.0 rifampicin
mmpL5 775835 c.2646C>G synonymous_variant 0.69 bedaquiline
clofazimine
mmpL5 775847 c.2634G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
mmpL5 775850 p.Ser877Thr missense_variant 0.67 bedaquiline
clofazimine
mmpL5 775856 c.2625T>C synonymous_variant 1.0 bedaquiline
clofazimine
mmpL5 775862 c.2619G>C synonymous_variant 0.87 bedaquiline
clofazimine
mmpL5 775886 c.2595A>T synonymous_variant 1.0 bedaquiline
clofazimine
mmpL5 775889 c.2592C>G synonymous_variant 0.88 bedaquiline
clofazimine
mmpL5 775898 c.2583G>A synonymous_variant 0.69 bedaquiline
clofazimine
mmpL5 775909 p.Leu858Ile missense_variant 0.83 bedaquiline
clofazimine
mmpL5 775910 c.2569_2571delCGGinsAGA synonymous_variant 0.67 bedaquiline
clofazimine
mmpL5 775916 c.2565T>C synonymous_variant 1.0 bedaquiline
clofazimine
mmpL5 775937 c.2544G>C synonymous_variant 0.63 bedaquiline
clofazimine
mmpL5 775949 c.2532G>C synonymous_variant 0.92 bedaquiline
clofazimine
mmpL5 775955 p.Ile842Val missense_variant 0.73 bedaquiline
clofazimine
mmpL5 775961 c.2520C>G synonymous_variant 1.0 bedaquiline
clofazimine
mmpL5 775975 p.Leu836Met missense_variant 0.75 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 1.0 bedaquiline
clofazimine
rpsL 781796 p.Met79Ile missense_variant 0.53 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.59 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.41 streptomycin
rpsL 781808 c.249C>G synonymous_variant 0.65 streptomycin
rpsL 781817 c.258G>T synonymous_variant 1.0 streptomycin
rpsL 781829 c.270G>C synonymous_variant 1.0 streptomycin
rpsL 781832 c.273T>G synonymous_variant 1.0 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.65 streptomycin
rpsL 781853 c.294C>T synonymous_variant 0.39 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.45 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.55 streptomycin
rpsL 781868 c.309T>C synonymous_variant 1.0 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.37 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.6 streptomycin
rpsL 781881 p.Lys108Arg missense_variant 0.6 streptomycin
rpsL 781892 c.333A>G synonymous_variant 1.0 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.59 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.44 streptomycin
rpsL 781905 p.Arg116Lys missense_variant 0.56 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.44 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 1.0 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.5 streptomycin
rplC 800633 c.-176T>C upstream_gene_variant 1.0 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.75 linezolid
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.75 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.75 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 1.0 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 1.0 linezolid
rplC 800729 c.-80G>C upstream_gene_variant 0.82 linezolid
fbiC 1304508 p.Glu526Asp missense_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304511 c.1581C>G synonymous_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304532 c.1602G>A synonymous_variant 0.91 pretomanid
delamanid
clofazimine
fbiC 1304533 c.1603T>C synonymous_variant 0.91 pretomanid
delamanid
clofazimine
fbiC 1304544 p.Asp538Glu missense_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304562 c.1632G>C synonymous_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304567 p.Phe546Tyr missense_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304571 c.1641G>C synonymous_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.93 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304655 c.1725C>T synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304671 p.Val581Thr missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304751 c.1821C>G synonymous_variant 0.9 pretomanid
delamanid
clofazimine
fbiC 1304769 c.1839C>G synonymous_variant 0.9 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.9 pretomanid
delamanid
clofazimine
sigE 1364839 c.427T>C synonymous_variant 1.0 pyrazinamide
sigE 1364877 c.465G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
sigE 1364913 c.501C>G synonymous_variant 1.0 pyrazinamide
sigE 1364919 p.Asp169Glu missense_variant 1.0 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 1.0 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 1.0 pyrazinamide
rrs 1471914 n.69A>G non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.93 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471943 n.98T>C non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471967 n.122G>A non_coding_transcript_exon_variant 0.61 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471980 n.135G>T non_coding_transcript_exon_variant 0.53 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1471981 n.136C>G non_coding_transcript_exon_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.65 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472133 n.288G>A non_coding_transcript_exon_variant 0.56 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.64 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472215 n.370A>G non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.9 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472234 n.389T>C non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472279 n.434T>C non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.97 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472298 n.453_466delGTCCGGGTTCTCTCinsCTTCATCCTTTTGGGGT non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.96 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472426 n.581T>C non_coding_transcript_exon_variant 0.7 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472436 n.591G>T non_coding_transcript_exon_variant 0.7 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472437 n.592T>G non_coding_transcript_exon_variant 0.7 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472446 n.601T>G non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472466 n.621C>T non_coding_transcript_exon_variant 0.62 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472467 n.622G>C non_coding_transcript_exon_variant 0.62 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472486 n.641A>G non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472517 n.672T>C non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472545 n.700A>G non_coding_transcript_exon_variant 0.62 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472571 n.726G>T non_coding_transcript_exon_variant 0.56 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472572 n.727T>G non_coding_transcript_exon_variant 0.56 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>T non_coding_transcript_exon_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472583 n.738T>G non_coding_transcript_exon_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472585 n.740A>T non_coding_transcript_exon_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472673 n.828_838delTTTCCTTCCTTinsGTTCTTCCAC non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472996 n.1151T>C non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473062 n.1217T>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473065 n.1220C>A non_coding_transcript_exon_variant 0.76 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.78 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.92 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473288 n.1443_1449delCTCGGGAinsACTTGTGTGGG non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473314 n.1469A>G non_coding_transcript_exon_variant 0.93 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1474476 n.819C>G non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474496 n.839C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474528 n.871T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474529 n.872A>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474541 n.884G>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474658 n.1001A>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474948 n.1291C>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475028 n.1371G>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475031 n.1374G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475060 n.1403_1404insGT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475063 n.1406A>G non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1475064 n.1408_1410delGCA non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422_1431delTGCCCGCCGAinsCCTGCGCCGG non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475108 n.1451C>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475706 n.2049A>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475735 n.2078T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475740 n.2083G>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475757 n.2100_2101insG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475769 n.2112_2113insC non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475782 n.2125T>C non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475788 n.2131C>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1475791 n.2134A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475983 n.2326T>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475996 n.2339T>A non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1476000 n.2343G>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476060 n.2403T>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.78 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476491 n.2834T>C non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476530 n.2873C>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833970 c.429G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.64 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.73 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.64 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834285 c.744G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834307 p.Asp256Gln missense_variant 0.44 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834330 c.789C>G synonymous_variant 0.4 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>G synonymous_variant 0.5 pyrazinamide
rpsA 1834384 c.843A>G synonymous_variant 0.48 pyrazinamide
rpsA 1834387 c.846C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834395 p.Arg285His missense_variant 0.43 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.43 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834415 p.Ala292His missense_variant 0.42 pyrazinamide
rpsA 1834427 p.Ile296Val missense_variant 0.42 pyrazinamide Uncertain significance
rpsA 1834432 c.891G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834439 p.Lys300Arg missense_variant 0.4 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.48 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.58 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.6 pyrazinamide
kasA 2518534 c.420G>C synonymous_variant 1.0 isoniazid
kasA 2518564 c.450C>T synonymous_variant 1.0 isoniazid
kasA 2518567 c.453G>C synonymous_variant 1.0 isoniazid
kasA 2518570 c.456G>C synonymous_variant 1.0 isoniazid
kasA 2518573 c.459G>C synonymous_variant 1.0 isoniazid
kasA 2518574 p.Ile154Val missense_variant 1.0 isoniazid
kasA 2518579 c.465T>C synonymous_variant 1.0 isoniazid
kasA 2518582 c.468G>C synonymous_variant 1.0 isoniazid
kasA 2518583 p.Gln157Glu missense_variant 1.0 isoniazid
kasA 2518588 c.474T>C synonymous_variant 1.0 isoniazid
kasA 2518603 c.489G>T synonymous_variant 1.0 isoniazid
kasA 2518606 c.492G>C synonymous_variant 1.0 isoniazid
kasA 2518609 p.Met165Ile missense_variant 1.0 isoniazid
kasA 2518612 c.498C>G synonymous_variant 1.0 isoniazid
kasA 2518630 c.516G>C synonymous_variant 1.0 isoniazid
kasA 2518636 c.522C>T synonymous_variant 1.0 isoniazid
kasA 2518644 p.Ala177Gly missense_variant 1.0 isoniazid
kasA 2518651 c.537C>G synonymous_variant 1.0 isoniazid
kasA 2518657 c.543G>A synonymous_variant 1.0 isoniazid
kasA 2518672 c.558G>C synonymous_variant 1.0 isoniazid
kasA 2518715 p.Pro201Ala missense_variant 1.0 isoniazid
kasA 2518747 c.633C>G synonymous_variant 1.0 isoniazid
kasA 2518756 c.642G>T synonymous_variant 1.0 isoniazid
kasA 2518759 c.645C>G synonymous_variant 1.0 isoniazid
kasA 2518811 p.Asp233Asn missense_variant 1.0 isoniazid
kasA 2518822 c.708C>G synonymous_variant 1.0 isoniazid
kasA 2518825 c.711T>C synonymous_variant 1.0 isoniazid
kasA 2518828 c.714G>C synonymous_variant 1.0 isoniazid
kasA 2518849 c.735G>C synonymous_variant 1.0 isoniazid
lpqB 3625207 c.-297C>T upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrB 3625222 c.1392T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625240 c.-330T>C upstream_gene_variant 0.91 rifampicin
bedaquiline
lpqB 3625243 c.-333T>G upstream_gene_variant 0.91 rifampicin
bedaquiline
lpqB 3625255 c.-345T>C upstream_gene_variant 0.9 rifampicin
bedaquiline
mtrB 3625263 p.Tyr451His missense_variant 0.9 rifampicin
bedaquiline
mtrB 3625264 c.1350C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625267 c.1347T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625270 c.-360G>C upstream_gene_variant 0.9 rifampicin
bedaquiline
lpqB 3625279 c.-369C>G upstream_gene_variant 0.9 rifampicin
bedaquiline
lpqB 3625282 c.-372C>G upstream_gene_variant 0.9 rifampicin
bedaquiline
lpqB 3625291 c.-381A>G upstream_gene_variant 0.9 rifampicin
bedaquiline
mtrB 3625750 p.Gln288Asn missense_variant 1.0 rifampicin
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 1.0 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.94 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 1.0 rifampicin
bedaquiline
rpoA 3877656 c.852T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.9 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.9 rifampicin
rpoA 3877674 c.834C>T synonymous_variant 0.91 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.92 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.92 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 1.0 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 1.0 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877758 c.750G>C synonymous_variant 1.0 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 1.0 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.83 rifampicin
rpoA 3877860 c.648C>T synonymous_variant 0.83 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 1.0 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.8 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
clpC1 4038755 c.1950G>T synonymous_variant 0.73 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038782 p.Val641Ile missense_variant 1.0 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4038794 c.1909_1911delAGCinsTCG synonymous_variant 1.0 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 1.0 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 1.0 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 1.0 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 1.0 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039359 p.Ser449Asn missense_variant 1.0 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039385 c.1320C>T synonymous_variant 0.71 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.77 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039436 c.1269G>A synonymous_variant 0.7 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039481 p.Ala408Ser missense_variant 1.0 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.42 pyrazinamide
clpC1 4039640 c.1065C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039647 p.Glu353Ser missense_variant 0.38 pyrazinamide
clpC1 4039649 p.Val352Leu missense_variant 0.58 pyrazinamide
clpC1 4039652 p.Thr351Ser missense_variant 0.58 pyrazinamide
clpC1 4039661 p.Gly348Ala missense_variant 0.37 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039670 p.Val345Ile missense_variant 0.37 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039685 c.1020C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.61 pyrazinamide
clpC1 4039697 c.1008C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039700 c.1005C>T synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4039709 p.Ile332Met missense_variant 0.4 pyrazinamide
clpC1 4039714 p.Tyr331His missense_variant 0.41 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039730 c.975C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039736 c.969C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 1.0 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039876 p.Asn277His missense_variant 0.32 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.4 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039945 p.Ser254Ala missense_variant 0.4 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 1.0 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040000 p.His235Lys missense_variant 0.42 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.59 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.58 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.94 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 1.0 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim