TB-Profiler result

Run: SRR26937107
Summary

Run ID: SRR26937107

Sample name:

Date: 2024-03-27T00:18:47.765540

Number of reads: 1378712

Percentage reads mapped: 90.73

Median coverage: 46.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
p.Asp354Ala Assoc w R
pyrazinamide pncA p.Asp63Ala Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1945_1947delATTinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2083_2085delACGinsTC Assoc w R - Interim Confers DLM-PMD cross-resistance
ddn p.Trp88* Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.9 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.67 streptomycin Assoc w R
fbiC 1304875 c.1945_1947delATTinsGG frameshift_variant&missense_variant 0.45 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305013 c.2083_2085delACGinsTC frameshift_variant&missense_variant 0.3 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2289054 p.Asp63Ala missense_variant 1.0 pyrazinamide Assoc w R
ddn 3987106 p.Trp88* stop_gained 1.0 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247429 p.Met306Val missense_variant 0.91 ethambutol Assoc w R
embB 4247574 p.Asp354Ala missense_variant 0.97 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 846 c.846T>C synonymous_variant 0.21 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.24 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.26 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.29 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.27 isoniazid
dnaA 909 c.909A>G synonymous_variant 0.28 isoniazid
dnaA 912 c.912T>G synonymous_variant 0.25 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.24 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.27 isoniazid
dnaA 930 c.930G>A synonymous_variant 0.27 isoniazid
dnaA 939 c.939C>T synonymous_variant 0.3 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.33 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.35 isoniazid
dnaA 963 c.963C>T synonymous_variant 0.33 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.32 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.28 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>C synonymous_variant 0.26 isoniazid
dnaA 993 c.993A>G synonymous_variant 0.23 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.23 isoniazid
dnaA 1002 c.1002G>A synonymous_variant 0.23 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1020 c.1020C>G synonymous_variant 0.22 isoniazid
dnaA 1023 c.1023C>T synonymous_variant 0.23 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.23 isoniazid
dnaA 1035 c.1035A>G synonymous_variant 0.22 isoniazid
dnaA 1038 c.1038A>C synonymous_variant 0.21 isoniazid
dnaA 1224 c.1224C>G synonymous_variant 0.2 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.22 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.26 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.24 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.24 isoniazid
dnaA 1291 c.1291_1293delCTTinsTA frameshift_variant&missense_variant 0.24 isoniazid Uncertain significance
dnaA 1299 c.1299G>T synonymous_variant 0.22 isoniazid
dnaA 1317 c.1317A>C synonymous_variant 0.2 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1329 c.1329A>G synonymous_variant 0.19 isoniazid
dnaA 1332 c.1332A>G synonymous_variant 0.19 isoniazid
gyrA 6637 c.-665T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6645 p.Ser469Thr missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6664 c.1425C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6703 c.-599G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6721 c.1482C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.21 levofloxacin Uncertain significance
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7625 c.324G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7655 c.354G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7667 c.366C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7700 c.399G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7706 c.405C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7709 c.408G>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 7725 c.424C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8168 c.867A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8357 c.1056G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8786 c.1485T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8796 c.1495_1497delATCinsGG frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.19 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9182 c.1881T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9192 c.1891C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575683 c.336G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575689 c.342G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.24 ethionamide
isoniazid Not assoc w R - Interim
mshA 575713 c.366G>A synonymous_variant 0.24 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.23 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.33 ethionamide
isoniazid
mshA 575761 c.414C>T synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575771 p.Val142Ser missense_variant 0.28 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.28 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.32 ethionamide
isoniazid
mshA 575851 c.504C>T synonymous_variant 0.34 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575864 c.517T>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575899 c.552G>A synonymous_variant 0.2 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.81 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.2 ethionamide
isoniazid
mshA 575924 p.Gly193Thr missense_variant 0.19 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.17 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 619525 c.-366C>T upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356C>G upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619540 c.-351C>G upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620238 c.348G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>A synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620269 p.Val127Ile missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>A synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620291 p.Tyr134Phe missense_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>A synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>T synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
hadA 731687 c.-243G>A upstream_gene_variant 0.26 isoniazid
hadA 731689 c.-241A>G upstream_gene_variant 0.27 isoniazid
hadA 731690 c.-240A>T upstream_gene_variant 0.27 isoniazid
hadA 731694 c.-236T>G upstream_gene_variant 0.28 isoniazid
hadA 731695 c.-235C>T upstream_gene_variant 0.28 isoniazid
hadA 731698 c.-232T>G upstream_gene_variant 0.28 isoniazid
hadA 731700 c.-230G>A upstream_gene_variant 0.28 isoniazid
hadA 731707 c.-223C>T upstream_gene_variant 0.3 isoniazid
hadA 731708 c.-222G>T upstream_gene_variant 0.29 isoniazid
hadA 731711 c.-219T>A upstream_gene_variant 0.29 isoniazid
hadA 731729 c.-201C>T upstream_gene_variant 0.35 isoniazid
hadA 731753 c.-177A>C upstream_gene_variant 0.29 isoniazid
hadA 731768 c.-162G>A upstream_gene_variant 0.23 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.17 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.22 isoniazid
hadA 732370 c.441C>T synonymous_variant 0.25 isoniazid
hadA 732374 c.445_447delGATinsAC frameshift_variant&missense_variant 0.25 isoniazid Uncertain significance
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.24 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.29 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.29 isoniazid
rpoB 760307 c.501T>C synonymous_variant 0.22 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.23 rifampicin
rpoB 760323 p.Leu173Val missense_variant 0.26 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.26 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760356 c.550_552delACCinsTG frameshift_variant&missense_variant 0.29 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.32 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.32 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.3 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760754 c.948G>C synonymous_variant 0.19 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.2 rifampicin
rpoB 760796 c.990A>G synonymous_variant 0.26 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.23 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.21 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.2 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760856 c.1050C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>T synonymous_variant 0.27 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.27 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.36 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.37 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>T synonymous_variant 0.45 rifampicin
rpoB 760970 c.1164G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>T synonymous_variant 0.4 rifampicin
rpoB 760985 c.1179G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.39 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.42 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.2 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.2 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.24 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.25 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.29 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.34 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.32 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.29 rifampicin
rpoB 761714 c.1908C>G synonymous_variant 0.28 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.29 rifampicin
rpoB 761735 c.1929C>G synonymous_variant 0.31 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.29 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.27 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.22 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.22 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.19 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.22 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.23 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.2 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.22 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.22 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.2 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 0.22 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.22 rifampicin
rpoC 763423 c.54G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.23 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>A synonymous_variant 0.19 rifampicin
rpoC 763573 c.204G>T synonymous_variant 0.19 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763836 p.Ala156Val missense_variant 0.2 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.22 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.22 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.25 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.24 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.25 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.25 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.29 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.31 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.33 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.34 rifampicin
rpoC 763969 c.600C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.37 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.28 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.29 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.31 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.32 rifampicin
rpoC 764044 c.675T>G synonymous_variant 0.31 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.3 rifampicin
rpoC 764080 c.711C>T synonymous_variant 0.31 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.29 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>G synonymous_variant 0.19 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.23 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.27 rifampicin
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.26 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.27 rifampicin
rpoC 764902 c.1533C>T synonymous_variant 0.29 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.32 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.26 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.22 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.2 rifampicin
rpoC 765079 c.1710T>C synonymous_variant 0.19 rifampicin
rpoC 765082 c.1713G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.19 rifampicin
rpoC 765292 c.1923G>T synonymous_variant 0.2 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 765305 p.Ile646Val missense_variant 0.2 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765328 p.His653Gln missense_variant 0.24 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.25 rifampicin Uncertain significance
rpoC 765334 c.1965C>T synonymous_variant 0.26 rifampicin
rpoC 765343 c.1974G>A synonymous_variant 0.29 rifampicin
rpoC 765352 c.1983G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765367 c.1998C>G synonymous_variant 0.29 rifampicin
rpoC 765370 c.2001G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.35 rifampicin Uncertain significance
rpoC 765404 c.2035C>T synonymous_variant 0.38 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.34 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.34 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>T synonymous_variant 0.34 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>A synonymous_variant 0.28 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765685 c.2316G>A synonymous_variant 0.33 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Lys missense_variant 0.42 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.42 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.42 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.41 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.43 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.43 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.43 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.42 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.41 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.46 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.45 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.4 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.26 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766333 c.2964G>C synonymous_variant 0.19 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.2 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.22 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.22 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.24 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.25 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.28 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.3 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.33 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.35 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.39 rifampicin
rpoC 766492 c.3123T>A synonymous_variant 0.4 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.4 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.33 rifampicin
rpoC 766540 c.3171C>T synonymous_variant 0.3 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.29 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.3 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.28 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.3 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.3 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.36 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.38 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.37 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.36 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.37 rifampicin
rpoC 766666 c.3297C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.37 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.45 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.44 rifampicin
rpoC 767152 c.3783T>G synonymous_variant 0.39 rifampicin
rpoC 767158 c.3789T>A synonymous_variant 0.38 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.37 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 0.33 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.33 rifampicin
rpoC 767209 c.3840T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.23 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.22 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.22 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.33 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.33 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.34 streptomycin
rpsL 781703 c.144G>A synonymous_variant 0.35 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.34 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.33 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.36 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.35 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.35 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.35 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.36 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.38 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.38 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.41 streptomycin
rpsL 781827 c.268C>T synonymous_variant 0.43 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.41 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.46 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.45 streptomycin
rpsL 781886 c.327C>T synonymous_variant 0.45 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.46 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.46 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.44 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.43 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.48 streptomycin
rplC 800546 c.-263T>C upstream_gene_variant 0.32 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.33 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.31 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.3 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.28 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.29 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.29 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.34 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.29 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 801195 c.387G>C synonymous_variant 0.22 linezolid
rplC 801207 c.399C>T synonymous_variant 0.25 linezolid
rplC 801210 c.402T>C synonymous_variant 0.26 linezolid
rplC 801222 c.414T>C synonymous_variant 0.25 linezolid
rplC 801228 c.420T>C synonymous_variant 0.26 linezolid
rplC 801246 c.438C>T synonymous_variant 0.22 linezolid
rplC 801255 c.447C>T synonymous_variant 0.24 linezolid
rplC 801267 c.459A>C synonymous_variant 0.24 linezolid
rplC 801270 c.462T>C synonymous_variant 0.24 linezolid
rplC 801276 c.468G>T synonymous_variant 0.24 linezolid
rplC 801279 c.471G>C synonymous_variant 0.24 linezolid
rplC 801285 c.477G>C synonymous_variant 0.22 linezolid
rplC 801288 c.480G>C synonymous_variant 0.26 linezolid
rplC 801300 c.492C>G synonymous_variant 0.28 linezolid
rplC 801309 c.501C>G synonymous_variant 0.31 linezolid
rplC 801312 c.504G>C synonymous_variant 0.29 linezolid
rplC 801321 c.513C>T synonymous_variant 0.28 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.27 linezolid
rplC 801339 c.531T>G synonymous_variant 0.21 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.21 linezolid
rplC 801348 c.540T>G synonymous_variant 0.2 linezolid
rplC 801357 c.549T>C synonymous_variant 0.19 linezolid
rplC 801378 c.570C>T synonymous_variant 0.18 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303584 c.654C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303645 p.Ala239Gln missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304823 c.1893C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.39 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304915 p.Asp662Gly missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304922 c.1992C>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304988 c.2058G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305006 p.Glu692Asp missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305009 c.2079C>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
sigE 1364883 c.471G>A synonymous_variant 0.18 pyrazinamide
sigE 1364889 c.477A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
sigE 1364892 c.480C>G synonymous_variant 0.21 pyrazinamide
sigE 1364910 c.498G>C synonymous_variant 0.26 pyrazinamide
sigE 1364913 c.501C>G synonymous_variant 0.27 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.28 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.29 pyrazinamide
sigE 1364931 c.519C>G synonymous_variant 0.32 pyrazinamide
sigE 1364952 c.540A>G synonymous_variant 0.36 pyrazinamide
sigE 1364955 c.543G>C synonymous_variant 0.35 pyrazinamide
sigE 1364961 c.549A>G synonymous_variant 0.35 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.33 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.33 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.33 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.33 pyrazinamide
sigE 1365012 c.600G>C synonymous_variant 0.33 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.29 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.23 pyrazinamide
sigE 1365036 c.624T>C synonymous_variant 0.24 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.23 pyrazinamide
sigE 1365045 c.633C>T synonymous_variant 0.24 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472445 n.601_604delTCTC non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472451 n.606_607insCGGG non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>C non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474286 n.629C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475401 n.1745delC non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475446 n.1789G>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475453 n.1796T>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475487 n.1830C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid Uncertain significance
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475605 n.1948A>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475617 n.1960C>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475625 n.1968G>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475637 n.1980T>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475759 n.2102_2106delCCCGCinsTCGT non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476595 n.2938C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476602 n.2945G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833532 c.-10A>C upstream_gene_variant 0.21 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.29 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.31 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1833782 p.Ser81Thr missense_variant 0.33 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833799 c.258C>A synonymous_variant 0.33 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833808 c.267G>T synonymous_variant 0.33 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.35 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.35 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.33 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.27 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.36 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.41 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.4 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.32 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.27 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>T synonymous_variant 0.28 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834252 c.711C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834258 c.717G>A synonymous_variant 0.26 pyrazinamide
rpsA 1834259 c.718_720delCTAinsTG frameshift_variant&stop_gained 0.26 pyrazinamide Uncertain significance
rpsA 1834264 c.723G>T synonymous_variant 0.26 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834282 c.741C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834440 p.Lys300Met missense_variant 0.31 pyrazinamide
rpsA 1834444 c.903C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.31 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.34 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834517 c.976C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.45 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834615 c.1074C>T synonymous_variant 0.49 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.48 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.34 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.34 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAC frameshift_variant&missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1834756 c.1215G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.29 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.29 pyrazinamide
rpsA 1834767 p.Lys409Thr missense_variant 0.29 pyrazinamide
rpsA 1834775 p.Ala412Asn missense_variant 0.28 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.29 pyrazinamide
tsnR 1853432 c.-174G>C upstream_gene_variant 0.26 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.26 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.22 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.22 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.24 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.24 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.23 isoniazid
kasA 2518010 c.-105C>G upstream_gene_variant 0.27 isoniazid
kasA 2518013 c.-102G>A upstream_gene_variant 0.25 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.24 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.23 isoniazid
kasA 2518031 c.-84G>T upstream_gene_variant 0.23 isoniazid
kasA 2518034 c.-81T>C upstream_gene_variant 0.22 isoniazid
kasA 2518035 c.-80C>G upstream_gene_variant 0.22 isoniazid
kasA 2518041 c.-74T>C upstream_gene_variant 0.22 isoniazid
kasA 2518049 c.-66G>C upstream_gene_variant 0.22 isoniazid
folC 2747314 c.285A>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747341 c.256_258delGTCinsCG frameshift_variant&missense_variant 0.2 para-aminosalicylic_acid
Rv2477c 2783203 c.840C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783281 c.762G>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783338 c.705C>T synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.44 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783461 c.582T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783491 c.552C>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783548 c.495T>A synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783566 c.477C>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783650 c.393C>T synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783659 c.384A>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783668 c.375G>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783752 c.291G>A synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783812 c.231G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783836 c.207C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783842 c.201C>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783851 c.192G>A synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 p.Tyr29Phe missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2681 2997033 p.Ala99Pro missense_variant 0.18 capreomycin
Rv2752c 3066456 c.-265A>G upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066465 c.-274G>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066468 c.-277C>G upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066471 c.-280A>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066474 c.-283G>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066504 c.-313C>G upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066513 c.-322C>G upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066543 c.-352C>G upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066560 c.-369C>T upstream_gene_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>T upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>A upstream_gene_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066597 c.-406C>T upstream_gene_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066636 c.-445G>A upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066644 c.-453T>C upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066646 c.-455C>T upstream_gene_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066672 c.-481G>C upstream_gene_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066676 c.-485C>T upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066685 c.-495_-494delGGinsCC upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066699 c.-508C>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067316 c.630A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067360 p.Ile196Val missense_variant 0.29 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067382 c.564C>T synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067385 c.561C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067418 c.528C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067436 c.510C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.18 para-aminosalicylic_acid
ald 3086731 c.-89A>G upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625528 c.-618G>T upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625570 c.-660G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625579 c.-669A>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625582 c.-672C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625585 c.-675G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.29 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625615 p.Arg333Gln missense_variant 0.34 bedaquiline
rifampicin
lpqB 3625621 c.-711G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625633 p.Asp327Glu missense_variant 0.4 bedaquiline
rifampicin
mtrB 3625638 p.Ala326Ser missense_variant 0.4 bedaquiline
rifampicin
lpqB 3625663 c.-753G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625669 c.-759G>A upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625693 c.-783G>T upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3625708 c.906C>T synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.45 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625792 c.-882G>A upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625804 c.808_810delAGGinsCA frameshift_variant&missense_variant 0.41 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625807 c.807C>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625846 c.-936G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625860 p.Ala252Ser missense_variant 0.31 bedaquiline
rifampicin
lpqB 3625888 c.-978G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625909 c.-999T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625915 c.699G>A synonymous_variant 0.35 bedaquiline
rifampicin
mtrB 3625927 c.687T>C synonymous_variant 0.32 bedaquiline
rifampicin
mtrB 3625930 c.684C>A synonymous_variant 0.28 bedaquiline
rifampicin
mtrB 3625936 c.678C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625942 c.672C>G synonymous_variant 0.27 bedaquiline
rifampicin
mtrB 3625945 c.667_669delCTAinsTG frameshift_variant&synonymous_variant 0.26 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625951 c.663A>G synonymous_variant 0.26 bedaquiline
rifampicin
mtrB 3625955 p.Leu220Ala missense_variant 0.28 bedaquiline
rifampicin
mtrB 3625960 c.654C>T synonymous_variant 0.28 bedaquiline
rifampicin
mtrB 3625967 p.Ala216Ile missense_variant 0.29 bedaquiline
rifampicin
mtrB 3625978 c.636T>C synonymous_variant 0.33 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626783 c.-170C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626819 c.-206G>A upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3627113 c.-500C>T upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627122 c.-509T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627175 c.175C>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627181 c.-568T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627185 c.163_165delTTGinsCT frameshift_variant&missense_variant 0.29 bedaquiline
rifampicin
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.28 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.3 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.32 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.3 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.27 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.27 rifampicin
rpoA 3877752 c.756C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.31 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.31 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.34 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.34 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.35 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.33 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.26 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.25 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.27 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877956 p.Glu184Asp missense_variant 0.67 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.36 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.32 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.29 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.29 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.3 rifampicin
rpoA 3878043 c.465G>C synonymous_variant 0.31 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.31 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.31 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.28 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.26 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.26 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.25 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.27 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>T synonymous_variant 0.24 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.23 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.25 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.23 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.25 rifampicin
rpoA 3878262 c.244_246delAGCinsGT frameshift_variant&synonymous_variant 0.25 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.34 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.42 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878355 c.153C>G synonymous_variant 0.53 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.52 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.51 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878406 c.102G>T synonymous_variant 0.55 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.53 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.56 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.56 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.55 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.49 rifampicin
rpoA 3878471 p.Val13Ile missense_variant 0.43 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.43 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878725 c.-220_-218delCTAinsTG upstream_gene_variant 0.32 rifampicin
rpoA 3878728 c.-221G>A upstream_gene_variant 0.32 rifampicin
rpoA 3878734 c.-229_-227delATCinsGG upstream_gene_variant 0.31 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.3 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.35 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.34 rifampicin
rpoA 3878755 c.-248G>T upstream_gene_variant 0.32 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.37 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.4 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.41 rifampicin
rpoA 3878818 c.-311G>C upstream_gene_variant 0.47 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.46 rifampicin
rpoA 3878837 c.-331_-330delAAinsGG upstream_gene_variant 0.47 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.51 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.49 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.47 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.43 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.35 rifampicin
rpoA 3878991 c.-484C>A upstream_gene_variant 0.4 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3879006 c.-499A>C upstream_gene_variant 0.43 rifampicin
rpoA 3879013 c.-508_-506delGAAinsAC upstream_gene_variant 0.44 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.46 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.49 rifampicin
rpoA 3879033 c.-526C>A upstream_gene_variant 0.47 rifampicin
rpoA 3879034 c.-527G>C upstream_gene_variant 0.49 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.49 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.48 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.51 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.53 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.54 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.52 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.52 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.42 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.41 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.26 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879238 c.-731C>G upstream_gene_variant 0.21 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.19 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.16 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.18 delamanid
pretomanid
ddn 3986681 c.-163C>G upstream_gene_variant 0.21 delamanid
pretomanid
clpC1 4038374 c.2331C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038395 c.2310C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038422 c.2283G>A synonymous_variant 0.26 pyrazinamide
clpC1 4038428 c.2277G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038436 p.Ala757Ser missense_variant 0.24 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.23 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.25 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.29 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.31 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.35 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.27 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.26 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038692 c.2013C>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038698 c.2007C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.37 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038815 c.1890G>A synonymous_variant 0.39 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.37 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038881 c.1824C>T synonymous_variant 0.35 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.35 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.32 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.32 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039043 c.1662G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039140 p.Glu522Val missense_variant 0.2 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039148 c.1557C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039238 c.1467C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039319 c.1384_1386delGCTinsAC frameshift_variant&missense_variant 0.26 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.26 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.27 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.18 pyrazinamide
panD 4044747 c.-466T>C upstream_gene_variant 0.18 pyrazinamide
panD 4044749 c.-468G>C upstream_gene_variant 0.18 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.17 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.18 pyrazinamide
panD 4044785 c.-504C>G upstream_gene_variant 0.18 pyrazinamide
panD 4044788 c.-507G>A upstream_gene_variant 0.19 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.18 pyrazinamide
panD 4044809 c.-528C>G upstream_gene_variant 0.19 pyrazinamide
panD 4044820 c.-539C>T upstream_gene_variant 0.19 pyrazinamide
panD 4044822 c.-541G>C upstream_gene_variant 0.18 pyrazinamide
panD 4044824 c.-543C>T upstream_gene_variant 0.18 pyrazinamide
panD 4044837 c.-556C>G upstream_gene_variant 0.18 pyrazinamide
embC 4240726 c.864G>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4240759 c.897C>G synonymous_variant 0.25 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.26 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.25 ethambutol
embC 4240811 c.949_951delTTCinsCG frameshift_variant&missense_variant 0.27 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.27 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.35 ethambutol
embC 4240837 c.975C>G synonymous_variant 0.35 ethambutol
embC 4240859 c.997_999delCTGinsAA frameshift_variant&missense_variant 0.31 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.3 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.31 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.32 ethambutol
embC 4240880 p.Ala340Ser missense_variant 0.32 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.3 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.27 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.27 ethambutol
embC 4240918 c.1056G>C synonymous_variant 0.24 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.24 ethambutol
embC 4240927 c.1065C>T synonymous_variant 0.23 ethambutol
embC 4240935 p.Val358Ala missense_variant 0.21 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243346 c.114A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248046 p.Lys511Asn missense_variant 0.19 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.19 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248085 c.1572T>C synonymous_variant 0.2 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.17 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248173 p.Val554Leu missense_variant 0.24 ethambutol
embB 4248199 c.1686A>C synonymous_variant 0.28 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.27 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.28 ethambutol Uncertain significance
embB 4248211 c.1698G>C synonymous_variant 0.26 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248226 c.1713G>C synonymous_variant 0.29 ethambutol
embB 4248232 c.1719G>A synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248233 c.1720C>T synonymous_variant 0.26 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.31 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.4 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.36 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.24 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.27 ethambutol
embB 4248328 c.1815G>C synonymous_variant 0.29 ethambutol
embB 4248337 c.1824G>C synonymous_variant 0.23 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.21 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.21 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.2 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Lys missense_variant 0.21 ethambutol
embB 4248388 c.1875G>C synonymous_variant 0.16 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.95 ethambutol Not assoc w R
whiB6 4338371 p.Thr51Pro missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R