Run ID: SRR26937107
Sample name:
Date: 2024-10-04T15:48:35.512628
Number of reads: 1378712
Percentage reads mapped: 90.73
Median coverage: 46.0
Strain: lineage2.2.1
Spoligotype:
Drug-resistance: MDR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage2 | East-Asian | RD105 | 0.98 |
lineage2.2.1 | East-Asian (Beijing) | RD105;RD207;RD181 | 1.0 |
lineage2.2 | East-Asian (Beijing) | RD105;RD207 | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Ser450Leu | Assoc w R | |
isoniazid | katG | p.Ser315Thr | Assoc w R | High-level resistance |
ethambutol | embB | p.Met306Val | Assoc w R | |
p.Asp354Ala | Assoc w R | |||
pyrazinamide | pncA | p.Asp63Ala | Assoc w R | |
streptomycin | rpsL | p.Lys43Arg | Assoc w R | |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ddn | p.Trp88* | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 0.9 | rifampicin | Assoc w R | |
rpsL | 781687 | p.Lys43Arg | missense_variant | 0.67 | streptomycin | Assoc w R | |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid | Assoc w R | High-level resistance |
pncA | 2289054 | p.Asp63Ala | missense_variant | 1.0 | pyrazinamide | Assoc w R | |
ddn | 3987106 | p.Trp88* | stop_gained | 1.0 | delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
embB | 4247429 | p.Met306Val | missense_variant | 0.91 | ethambutol | Assoc w R | |
embB | 4247574 | p.Asp354Ala | missense_variant | 0.97 | ethambutol | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 846 | c.846T>C | synonymous_variant | 0.21 | isoniazid | |
dnaA | 849 | c.849A>G | synonymous_variant | 0.24 | isoniazid | |
dnaA | 876 | c.876C>G | synonymous_variant | 0.26 | isoniazid | |
dnaA | 885 | c.885T>C | synonymous_variant | 0.29 | isoniazid | |
dnaA | 897 | c.897A>G | synonymous_variant | 0.27 | isoniazid | |
dnaA | 909 | c.909A>G | synonymous_variant | 0.28 | isoniazid | |
dnaA | 912 | c.912T>G | synonymous_variant | 0.25 | isoniazid | |
dnaA | 918 | c.918C>G | synonymous_variant | 0.24 | isoniazid | |
dnaA | 921 | c.921A>G | synonymous_variant | 0.24 | isoniazid | Not assoc w R - Interim |
dnaA | 927 | c.927G>A | synonymous_variant | 0.27 | isoniazid | |
dnaA | 930 | c.930G>A | synonymous_variant | 0.27 | isoniazid | |
dnaA | 939 | c.939C>T | synonymous_variant | 0.3 | isoniazid | |
dnaA | 945 | c.945G>A | synonymous_variant | 0.33 | isoniazid | |
dnaA | 955 | c.955A>C | synonymous_variant | 0.35 | isoniazid | |
dnaA | 963 | c.963C>T | synonymous_variant | 0.33 | isoniazid | |
dnaA | 966 | c.966T>C | synonymous_variant | 0.32 | isoniazid | |
dnaA | 975 | c.975G>T | synonymous_variant | 0.28 | isoniazid | |
dnaA | 984 | c.984T>C | synonymous_variant | 0.29 | isoniazid | Not assoc w R - Interim |
dnaA | 990 | c.990A>C | synonymous_variant | 0.26 | isoniazid | |
dnaA | 993 | c.993A>G | synonymous_variant | 0.23 | isoniazid | |
dnaA | 999 | c.999C>G | synonymous_variant | 0.23 | isoniazid | |
dnaA | 1002 | c.1002G>A | synonymous_variant | 0.23 | isoniazid | |
dnaA | 1008 | c.1008G>A | synonymous_variant | 0.22 | isoniazid | Not assoc w R - Interim |
dnaA | 1020 | c.1020C>G | synonymous_variant | 0.22 | isoniazid | |
dnaA | 1023 | c.1023C>T | synonymous_variant | 0.23 | isoniazid | |
dnaA | 1024 | c.1024T>C | synonymous_variant | 0.23 | isoniazid | |
dnaA | 1035 | c.1035A>G | synonymous_variant | 0.22 | isoniazid | |
dnaA | 1038 | c.1038A>C | synonymous_variant | 0.21 | isoniazid | |
dnaA | 1224 | c.1224C>G | synonymous_variant | 0.2 | isoniazid | |
dnaA | 1245 | c.1245G>C | synonymous_variant | 0.2 | isoniazid | Not assoc w R - Interim |
dnaA | 1254 | c.1254T>C | synonymous_variant | 0.22 | isoniazid | |
dnaA | 1278 | c.1278T>C | synonymous_variant | 0.26 | isoniazid | |
dnaA | 1287 | c.1287A>G | synonymous_variant | 0.24 | isoniazid | |
dnaA | 1290 | c.1290G>A | synonymous_variant | 0.24 | isoniazid | |
dnaA | 1291 | c.1291_1293delCTTinsTTA | synonymous_variant | 0.24 | isoniazid | |
dnaA | 1299 | c.1299G>T | synonymous_variant | 0.22 | isoniazid | |
dnaA | 1317 | c.1317A>C | synonymous_variant | 0.2 | isoniazid | |
dnaA | 1323 | c.1323C>T | synonymous_variant | 0.21 | isoniazid | Not assoc w R - Interim |
dnaA | 1329 | c.1329A>G | synonymous_variant | 0.19 | isoniazid | |
dnaA | 1332 | c.1332A>G | synonymous_variant | 0.19 | isoniazid | |
gyrA | 6637 | c.-665T>G | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6640 | c.-662A>G | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6645 | p.Ser469Thr | missense_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6649 | c.-653T>G | upstream_gene_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6655 | c.-647T>C | upstream_gene_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6664 | c.1425C>T | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6673 | c.-629A>C | upstream_gene_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6676 | c.-626T>G | upstream_gene_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6680 | c.1441C>T | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6703 | c.-599G>C | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6706 | c.-596G>A | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6709 | c.-593A>G | upstream_gene_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6712 | c.-590G>A | upstream_gene_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6721 | c.1482C>T | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6728 | c.-574_-572delCTAinsTTG | upstream_gene_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6745 | c.1506T>C | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7625 | c.324G>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7652 | c.351C>T | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7655 | c.354G>A | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7658 | c.357A>G | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7664 | c.363T>C | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7667 | c.366C>T | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7670 | c.369A>G | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7676 | c.375G>C | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7679 | c.378G>C | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7683 | c.382A>C | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7694 | c.393A>G | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7697 | c.396C>G | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7700 | c.399G>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7706 | c.405C>G | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7709 | c.408G>T | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7710 | c.409_411delTTGinsCTC | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7725 | c.424C>T | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7728 | c.427_429delAGGinsCGC | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7760 | c.459C>T | synonymous_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7763 | c.462T>C | synonymous_variant | 0.26 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8168 | c.867A>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8174 | c.873C>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8177 | c.876A>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8198 | c.897T>C | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8207 | c.906T>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8283 | p.Ile328Leu | missense_variant | 0.2 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8288 | c.987T>C | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8294 | c.993T>C | synonymous_variant | 0.25 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8339 | c.1038A>G | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8357 | c.1056G>A | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8756 | c.1455A>G | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8762 | c.1461G>C | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8767 | p.Arg489Lys | missense_variant | 0.2 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8786 | c.1485T>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8796 | p.Ile499Val | missense_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8810 | c.1509A>T | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9119 | c.1818A>G | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9128 | c.1827C>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9143 | c.1842T>C | synonymous_variant | 0.19 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9182 | c.1881T>C | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9192 | c.1891C>T | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R | |||||
mshA | 575683 | c.336G>C | synonymous_variant | 0.22 | isoniazid | |
ethionamide | ||||||
mshA | 575689 | c.342G>C | synonymous_variant | 0.22 | isoniazid | |
ethionamide | ||||||
mshA | 575695 | c.348C>G | synonymous_variant | 0.24 | isoniazid | Not assoc w R - Interim |
ethionamide | ||||||
mshA | 575713 | c.366G>A | synonymous_variant | 0.24 | isoniazid | |
ethionamide | ||||||
mshA | 575719 | c.372C>T | synonymous_variant | 0.23 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
mshA | 575734 | c.387T>G | synonymous_variant | 0.3 | isoniazid | |
ethionamide | ||||||
mshA | 575737 | c.390T>C | synonymous_variant | 0.32 | isoniazid | |
ethionamide | ||||||
mshA | 575746 | c.399C>G | synonymous_variant | 0.33 | isoniazid | |
ethionamide | ||||||
mshA | 575761 | c.414C>T | synonymous_variant | 0.31 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
mshA | 575771 | p.Val142Ser | missense_variant | 0.28 | isoniazid | |
ethionamide | ||||||
mshA | 575776 | c.429C>T | synonymous_variant | 0.28 | isoniazid | |
ethionamide | ||||||
mshA | 575779 | c.432A>G | synonymous_variant | 0.28 | isoniazid | |
ethionamide | ||||||
mshA | 575782 | c.435G>C | synonymous_variant | 0.28 | isoniazid | |
ethionamide | ||||||
mshA | 575785 | c.438T>C | synonymous_variant | 0.28 | isoniazid | |
ethionamide | ||||||
mshA | 575821 | c.474G>C | synonymous_variant | 0.33 | isoniazid | |
ethionamide | ||||||
mshA | 575824 | c.477T>A | synonymous_variant | 0.32 | isoniazid | |
ethionamide | ||||||
mshA | 575851 | c.504C>T | synonymous_variant | 0.34 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
mshA | 575864 | c.517T>C | synonymous_variant | 0.33 | isoniazid | |
ethionamide | ||||||
mshA | 575878 | c.531A>G | synonymous_variant | 0.24 | isoniazid | |
ethionamide | ||||||
mshA | 575884 | c.537G>C | synonymous_variant | 0.24 | isoniazid | |
ethionamide | ||||||
mshA | 575893 | c.546C>G | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
mshA | 575899 | c.552G>A | synonymous_variant | 0.2 | isoniazid | |
ethionamide | ||||||
mshA | 575905 | c.558G>C | synonymous_variant | 0.2 | isoniazid | |
ethionamide | ||||||
mshA | 575907 | p.Ala187Val | missense_variant | 0.81 | isoniazid | Not assoc w R |
ethionamide | Not assoc w R | |||||
mshA | 575916 | p.Asp190Ala | missense_variant | 0.2 | isoniazid | |
ethionamide | ||||||
mshA | 575924 | p.Gly193Thr | missense_variant | 0.19 | isoniazid | |
ethionamide | ||||||
mshA | 575944 | c.597T>C | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
ccsA | 619507 | c.-384A>G | upstream_gene_variant | 0.21 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 619525 | c.-366C>T | upstream_gene_variant | 0.2 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 619531 | c.-360T>C | upstream_gene_variant | 0.19 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 619535 | c.-356C>G | upstream_gene_variant | 0.18 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 619540 | c.-351C>G | upstream_gene_variant | 0.18 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620238 | c.348G>C | synonymous_variant | 0.32 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620245 | c.355T>C | synonymous_variant | 0.31 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620249 | p.Ser120Cys | missense_variant | 0.32 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620256 | c.366C>G | synonymous_variant | 0.33 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620268 | c.378G>A | synonymous_variant | 0.3 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620269 | p.Val127Ile | missense_variant | 0.3 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620283 | c.393T>A | synonymous_variant | 0.33 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620284 | p.Ala132Pro | missense_variant | 0.3 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620288 | p.Arg133Gln | missense_variant | 0.3 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620291 | p.Tyr134Phe | missense_variant | 0.32 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620295 | c.405G>C | synonymous_variant | 0.32 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620307 | c.417C>A | synonymous_variant | 0.35 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620317 | p.Val143Leu | missense_variant | 0.38 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620340 | c.450C>G | synonymous_variant | 0.37 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620349 | c.459A>G | synonymous_variant | 0.34 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620362 | p.Ala158Thr | missense_variant | 0.3 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620373 | c.483C>T | synonymous_variant | 0.2 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620376 | c.486G>C | synonymous_variant | 0.2 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620625 | p.Ile245Met | missense_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
Rv0565c | 657081 | c.390G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
Rv0565c | 657142 | p.Arg110His | missense_variant | 1.0 | ethionamide | Uncertain significance |
hadA | 731687 | c.-243G>A | upstream_gene_variant | 0.26 | isoniazid | |
hadA | 731689 | c.-241A>G | upstream_gene_variant | 0.27 | isoniazid | |
hadA | 731690 | c.-240A>T | upstream_gene_variant | 0.27 | isoniazid | |
hadA | 731694 | c.-236T>G | upstream_gene_variant | 0.28 | isoniazid | |
hadA | 731695 | c.-235C>T | upstream_gene_variant | 0.28 | isoniazid | |
hadA | 731698 | c.-232T>G | upstream_gene_variant | 0.28 | isoniazid | |
hadA | 731700 | c.-230G>A | upstream_gene_variant | 0.28 | isoniazid | |
hadA | 731707 | c.-223C>T | upstream_gene_variant | 0.3 | isoniazid | |
hadA | 731708 | c.-222G>T | upstream_gene_variant | 0.29 | isoniazid | |
hadA | 731711 | c.-219T>A | upstream_gene_variant | 0.29 | isoniazid | |
hadA | 731729 | c.-201C>T | upstream_gene_variant | 0.35 | isoniazid | |
hadA | 731753 | c.-177A>C | upstream_gene_variant | 0.29 | isoniazid | |
hadA | 731768 | c.-162G>A | upstream_gene_variant | 0.23 | isoniazid | |
hadA | 731774 | c.-156T>C | upstream_gene_variant | 0.17 | isoniazid | |
hadA | 732346 | c.417T>C | synonymous_variant | 0.22 | isoniazid | |
hadA | 732370 | c.441C>T | synonymous_variant | 0.25 | isoniazid | |
hadA | 732374 | p.Asp149Asn | missense_variant | 0.25 | isoniazid | |
hadA | 732378 | c.450_452dupAGA | disruptive_inframe_insertion | 0.24 | isoniazid | |
hadA | 732396 | p.Gly156Ala | missense_variant | 0.29 | isoniazid | |
hadA | 732398 | p.Ala157Thr | missense_variant | 0.29 | isoniazid | |
rpoB | 760307 | c.501T>C | synonymous_variant | 0.22 | rifampicin | |
rpoB | 760310 | c.504G>C | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760323 | p.Leu173Val | missense_variant | 0.26 | rifampicin | |
rpoB | 760328 | c.522G>C | synonymous_variant | 0.26 | rifampicin | |
rpoB | 760340 | c.534G>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760356 | p.Thr184Ser | missense_variant | 0.29 | rifampicin | Uncertain significance |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 760370 | c.564C>G | synonymous_variant | 0.32 | rifampicin | |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.32 | rifampicin | Uncertain significance |
rpoB | 760380 | p.Thr192Leu | missense_variant | 0.3 | rifampicin | |
rpoB | 760403 | c.597C>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 760415 | c.609C>T | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760424 | c.618C>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 760754 | c.948G>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760769 | c.963C>G | synonymous_variant | 0.2 | rifampicin | |
rpoB | 760796 | c.990A>G | synonymous_variant | 0.26 | rifampicin | |
rpoB | 760805 | c.999G>C | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760817 | c.1011A>G | synonymous_variant | 0.21 | rifampicin | |
rpoB | 760820 | c.1014T>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 760826 | c.1020C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760830 | c.1024T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760841 | c.1035T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 760856 | c.1050C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 760877 | c.1071G>T | synonymous_variant | 0.27 | rifampicin | |
rpoB | 760886 | c.1080A>G | synonymous_variant | 0.27 | rifampicin | |
rpoB | 760916 | c.1110C>T | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 760925 | c.1119T>C | synonymous_variant | 0.36 | rifampicin | |
rpoB | 760928 | c.1122G>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 760931 | c.1125C>G | synonymous_variant | 0.37 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 760964 | c.1158C>T | synonymous_variant | 0.45 | rifampicin | |
rpoB | 760970 | c.1164G>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 760982 | c.1176G>T | synonymous_variant | 0.4 | rifampicin | |
rpoB | 760985 | c.1179G>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 760991 | c.1185G>C | synonymous_variant | 0.39 | rifampicin | |
rpoB | 761006 | c.1200C>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoB | 761015 | c.1209G>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 761021 | c.1215G>C | synonymous_variant | 0.42 | rifampicin | |
rpoB | 761027 | c.1221A>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 761036 | c.1230G>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 761037 | c.1231T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 761057 | c.1251G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 761360 | c.1554T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761367 | p.Glu521Gln | missense_variant | 0.2 | rifampicin | |
rpoB | 761374 | p.Val523Asp | missense_variant | 0.2 | rifampicin | |
rpoB | 761636 | c.1830G>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 761645 | c.1839C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 761648 | c.1842T>C | synonymous_variant | 0.24 | rifampicin | |
rpoB | 761657 | c.1851C>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 761666 | c.1860G>C | synonymous_variant | 0.25 | rifampicin | |
rpoB | 761669 | c.1863C>T | synonymous_variant | 0.29 | rifampicin | |
rpoB | 761675 | c.1869G>C | synonymous_variant | 0.34 | rifampicin | |
rpoB | 761690 | c.1884G>C | synonymous_variant | 0.32 | rifampicin | |
rpoB | 761711 | c.1905C>G | synonymous_variant | 0.29 | rifampicin | |
rpoB | 761714 | c.1908C>G | synonymous_variant | 0.28 | rifampicin | |
rpoB | 761717 | c.1911C>G | synonymous_variant | 0.29 | rifampicin | |
rpoB | 761723 | p.GluSer640LysAla | missense_variant | 0.3 | rifampicin | |
rpoB | 761735 | c.1929C>G | synonymous_variant | 0.31 | rifampicin | |
rpoB | 761750 | c.1944G>C | synonymous_variant | 0.29 | rifampicin | |
rpoB | 761765 | c.1959T>C | synonymous_variant | 0.27 | rifampicin | |
rpoB | 761772 | p.His656Ala | missense_variant | 0.22 | rifampicin | |
rpoB | 761778 | p.Asn658Asp | missense_variant | 0.22 | rifampicin | |
rpoB | 761791 | p.Arg662His | missense_variant | 0.19 | rifampicin | |
rpoB | 762254 | c.2448T>G | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762257 | c.2451C>G | synonymous_variant | 0.23 | rifampicin | |
rpoB | 762284 | c.2478G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762293 | c.2487T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762314 | c.2508C>T | synonymous_variant | 0.2 | rifampicin | |
rpoB | 762317 | c.2511A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762347 | c.2541T>C | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762350 | c.2544C>G | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762362 | p.Glu852Asp | missense_variant | 0.2 | rifampicin | |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
rpoB | 763034 | c.3228C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 763082 | c.-288C>G | upstream_gene_variant | 0.22 | rifampicin | |
rpoB | 763085 | c.3279C>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 763402 | c.33C>T | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 763408 | c.39T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 763411 | c.42T>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 763414 | c.45T>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763423 | c.54G>A | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763441 | c.72C>T | synonymous_variant | 0.23 | rifampicin | |
rpoC | 763444 | c.75T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 763492 | c.123G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>A | synonymous_variant | 0.19 | rifampicin | |
rpoC | 763573 | c.204G>T | synonymous_variant | 0.19 | rifampicin | |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763836 | p.Ala156Val | missense_variant | 0.2 | rifampicin | |
rpoC | 763855 | c.486C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763858 | c.489A>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763872 | p.Gly168Ala | missense_variant | 0.25 | rifampicin | |
rpoC | 763876 | p.Glu169Asp | missense_variant | 0.24 | rifampicin | |
rpoC | 763879 | c.510A>G | synonymous_variant | 0.25 | rifampicin | |
rpoC | 763888 | c.519G>T | synonymous_variant | 0.25 | rifampicin | |
rpoC | 763894 | c.525A>G | synonymous_variant | 0.29 | rifampicin | |
rpoC | 763924 | c.555G>A | synonymous_variant | 0.31 | rifampicin | |
rpoC | 763936 | c.567C>G | synonymous_variant | 0.33 | rifampicin | |
rpoC | 763939 | c.570G>A | synonymous_variant | 0.34 | rifampicin | |
rpoC | 763969 | c.600C>T | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 763978 | c.609C>T | synonymous_variant | 0.37 | rifampicin | |
rpoC | 763991 | p.Ile208Leu | missense_variant | 0.26 | rifampicin | |
rpoC | 764002 | c.633C>G | synonymous_variant | 0.28 | rifampicin | |
rpoC | 764005 | c.636G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764011 | c.642T>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 764024 | c.655T>C | synonymous_variant | 0.31 | rifampicin | |
rpoC | 764040 | p.Ser224Thr | missense_variant | 0.32 | rifampicin | |
rpoC | 764044 | c.675T>G | synonymous_variant | 0.31 | rifampicin | |
rpoC | 764059 | c.690G>T | synonymous_variant | 0.3 | rifampicin | |
rpoC | 764080 | c.711C>T | synonymous_variant | 0.31 | rifampicin | |
rpoC | 764083 | c.714A>G | synonymous_variant | 0.29 | rifampicin | |
rpoC | 764098 | c.729A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764131 | c.762T>G | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764824 | c.1455T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764833 | c.1464A>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764872 | c.1503A>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764875 | c.1506C>G | synonymous_variant | 0.27 | rifampicin | |
rpoC | 764888 | c.1519_1521delTTGinsCTC | synonymous_variant | 0.25 | rifampicin | |
rpoC | 764893 | c.1524T>C | synonymous_variant | 0.26 | rifampicin | |
rpoC | 764896 | c.1527C>T | synonymous_variant | 0.27 | rifampicin | |
rpoC | 764902 | c.1533C>T | synonymous_variant | 0.29 | rifampicin | |
rpoC | 764923 | c.1554A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 764953 | c.1584G>C | synonymous_variant | 0.32 | rifampicin | |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764983 | c.1614T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764995 | c.1626C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R |
rpoC | 765007 | c.1638T>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 765008 | c.1639T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765019 | c.1650A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765040 | c.1671T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765041 | c.1672T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765047 | c.1678T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765052 | c.1683C>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765053 | c.1684_1685delTCinsAG | synonymous_variant | 0.22 | rifampicin | |
rpoC | 765073 | c.1704G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 765076 | c.1707A>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 765079 | c.1710T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 765082 | c.1713G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 765085 | c.1716T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 765292 | c.1923G>T | synonymous_variant | 0.2 | rifampicin | |
rpoC | 765300 | p.Val644Ala | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoC | 765305 | p.Ile646Val | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoC | 765319 | c.1950A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765328 | p.His653Gln | missense_variant | 0.24 | rifampicin | Uncertain significance |
rpoC | 765330 | p.Ser654Asn | missense_variant | 0.25 | rifampicin | Uncertain significance |
rpoC | 765334 | c.1965C>T | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765343 | c.1974G>A | synonymous_variant | 0.29 | rifampicin | |
rpoC | 765352 | c.1983G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 765367 | c.1998C>G | synonymous_variant | 0.29 | rifampicin | |
rpoC | 765370 | c.2001G>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 765383 | p.Met672Leu | missense_variant | 0.35 | rifampicin | Uncertain significance |
rpoC | 765404 | c.2035C>T | synonymous_variant | 0.38 | rifampicin | |
rpoC | 765409 | c.2040T>C | synonymous_variant | 0.34 | rifampicin | |
rpoC | 765412 | c.2043T>C | synonymous_variant | 0.34 | rifampicin | |
rpoC | 765421 | c.2052C>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 765451 | c.2082C>T | synonymous_variant | 0.34 | rifampicin | |
rpoC | 765478 | c.2109T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 765499 | c.2130C>A | synonymous_variant | 0.28 | rifampicin | |
rpoC | 765658 | c.2289C>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765685 | c.2316G>A | synonymous_variant | 0.33 | rifampicin | |
rpoC | 765700 | c.2331T>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 765728 | p.Gln787Lys | missense_variant | 0.42 | rifampicin | |
rpoC | 765734 | c.2365T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 765739 | c.2370G>T | synonymous_variant | 0.42 | rifampicin | |
rpoC | 765751 | c.2382C>G | synonymous_variant | 0.42 | rifampicin | |
rpoC | 765753 | p.Asp795Ala | missense_variant | 0.41 | rifampicin | Uncertain significance |
rpoC | 765772 | c.2403C>G | synonymous_variant | 0.43 | rifampicin | |
rpoC | 765784 | c.2415C>G | synonymous_variant | 0.43 | rifampicin | |
rpoC | 765787 | c.2418C>T | synonymous_variant | 0.43 | rifampicin | |
rpoC | 765793 | c.2424C>G | synonymous_variant | 0.42 | rifampicin | |
rpoC | 765796 | c.2427C>T | synonymous_variant | 0.41 | rifampicin | |
rpoC | 765811 | c.2442T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 765826 | c.2457T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoC | 765883 | c.2514C>G | synonymous_variant | 0.46 | rifampicin | |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.45 | rifampicin | |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoC | 765928 | c.2559C>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 765952 | c.2583G>C | synonymous_variant | 0.4 | rifampicin | |
rpoC | 765967 | c.2598C>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 765973 | c.2604C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765979 | c.2610C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765982 | c.2613C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 766333 | c.2964G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766345 | c.2976T>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766348 | c.2979A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766357 | c.2988C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766363 | c.2994G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766369 | c.3000C>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766381 | c.3012C>T | synonymous_variant | 0.25 | rifampicin | |
rpoC | 766384 | c.3015A>G | synonymous_variant | 0.28 | rifampicin | |
rpoC | 766390 | c.3021C>T | synonymous_variant | 0.3 | rifampicin | |
rpoC | 766408 | c.3039C>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 766426 | c.3057C>T | synonymous_variant | 0.33 | rifampicin | |
rpoC | 766456 | c.3087C>G | synonymous_variant | 0.35 | rifampicin | |
rpoC | 766486 | c.3117A>G | synonymous_variant | 0.39 | rifampicin | |
rpoC | 766492 | c.3123T>A | synonymous_variant | 0.4 | rifampicin | |
rpoC | 766522 | c.3153C>G | synonymous_variant | 0.4 | rifampicin | |
rpoC | 766530 | p.Arg1054Gln | missense_variant | 0.33 | rifampicin | |
rpoC | 766540 | c.3171C>T | synonymous_variant | 0.3 | rifampicin | |
rpoC | 766543 | c.3174C>T | synonymous_variant | 0.29 | rifampicin | |
rpoC | 766549 | c.3180G>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 766570 | c.3201T>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 766573 | c.3204T>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 766579 | c.3210C>T | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 766585 | c.3216T>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 766594 | c.3225G>C | synonymous_variant | 0.36 | rifampicin | |
rpoC | 766607 | p.Ile1080Leu | missense_variant | 0.38 | rifampicin | |
rpoC | 766630 | c.3261G>T | synonymous_variant | 0.37 | rifampicin | |
rpoC | 766657 | c.3288A>G | synonymous_variant | 0.36 | rifampicin | |
rpoC | 766660 | c.3291G>A | synonymous_variant | 0.37 | rifampicin | |
rpoC | 766666 | c.3297C>T | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 766672 | c.3303T>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 767033 | c.3664_3666delTCGinsAGT | synonymous_variant | 0.45 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 767134 | c.3765C>A | synonymous_variant | 0.44 | rifampicin | |
rpoC | 767152 | c.3783T>G | synonymous_variant | 0.39 | rifampicin | |
rpoC | 767158 | c.3789T>A | synonymous_variant | 0.38 | rifampicin | |
rpoC | 767167 | c.3798C>G | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 767180 | p.Ala1271Gln | missense_variant | 0.37 | rifampicin | |
rpoC | 767185 | c.3816G>T | synonymous_variant | 0.33 | rifampicin | |
rpoC | 767191 | c.3822C>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 767200 | c.3831G>A | synonymous_variant | 0.33 | rifampicin | |
rpoC | 767209 | c.3840T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 776182 | p.Asp767Asn | missense_variant | 1.0 | bedaquiline | Not assoc w R |
clofazimine | Not assoc w R | |||||
mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781595 | c.36T>C | synonymous_variant | 0.23 | streptomycin | |
rpsL | 781598 | c.39G>C | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781608 | p.Ser17Ala | missense_variant | 0.22 | streptomycin | |
rpsL | 781628 | c.69T>C | synonymous_variant | 0.28 | streptomycin | Not assoc w R - Interim |
rpsL | 781649 | c.90T>C | synonymous_variant | 0.33 | streptomycin | |
rpsL | 781655 | c.96T>C | synonymous_variant | 0.33 | streptomycin | |
rpsL | 781682 | c.123T>C | synonymous_variant | 0.34 | streptomycin | |
rpsL | 781703 | c.144G>A | synonymous_variant | 0.35 | streptomycin | |
rpsL | 781715 | c.156T>C | synonymous_variant | 0.34 | streptomycin | |
rpsL | 781718 | c.159C>G | synonymous_variant | 0.33 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.36 | streptomycin | |
rpsL | 781736 | c.177T>C | synonymous_variant | 0.35 | streptomycin | |
rpsL | 781751 | c.192G>C | synonymous_variant | 0.35 | streptomycin | |
rpsL | 781754 | c.195G>C | synonymous_variant | 0.35 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.36 | streptomycin | |
rpsL | 781763 | c.204C>G | synonymous_variant | 0.38 | streptomycin | |
rpsL | 781766 | c.207C>T | synonymous_variant | 0.38 | streptomycin | Not assoc w R - Interim |
rpsL | 781808 | c.249C>T | synonymous_variant | 0.41 | streptomycin | |
rpsL | 781827 | c.268C>T | synonymous_variant | 0.43 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.41 | streptomycin | |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.46 | streptomycin | |
rpsL | 781871 | c.312G>C | synonymous_variant | 0.45 | streptomycin | |
rpsL | 781886 | c.327C>T | synonymous_variant | 0.45 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.46 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.46 | streptomycin | |
rpsL | 781916 | c.357T>C | synonymous_variant | 0.44 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.43 | streptomycin | Uncertain significance |
rpsL | 781933 | c.374G>A | splice_region_variant&stop_retained_variant | 0.48 | streptomycin | |
rplC | 800546 | c.-263T>C | upstream_gene_variant | 0.32 | linezolid | |
rplC | 800567 | c.-242A>G | upstream_gene_variant | 0.33 | linezolid | |
rplC | 800579 | c.-230C>T | upstream_gene_variant | 0.31 | linezolid | |
rplC | 800582 | c.-227C>G | upstream_gene_variant | 0.3 | linezolid | |
rplC | 800612 | c.-197A>G | upstream_gene_variant | 0.28 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 0.29 | linezolid | |
rplC | 800627 | c.-182C>T | upstream_gene_variant | 0.29 | linezolid | |
rplC | 800648 | c.-161A>C | upstream_gene_variant | 0.34 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.29 | linezolid | |
rplC | 800723 | c.-86C>G | upstream_gene_variant | 0.18 | linezolid | |
rplC | 801195 | c.387G>C | synonymous_variant | 0.22 | linezolid | |
rplC | 801207 | c.399C>T | synonymous_variant | 0.25 | linezolid | |
rplC | 801210 | c.402T>C | synonymous_variant | 0.26 | linezolid | |
rplC | 801222 | c.414T>C | synonymous_variant | 0.25 | linezolid | |
rplC | 801228 | c.420T>C | synonymous_variant | 0.26 | linezolid | |
rplC | 801246 | c.438C>T | synonymous_variant | 0.22 | linezolid | |
rplC | 801255 | c.447C>T | synonymous_variant | 0.24 | linezolid | |
rplC | 801267 | c.459A>C | synonymous_variant | 0.24 | linezolid | |
rplC | 801270 | c.462T>C | synonymous_variant | 0.24 | linezolid | |
rplC | 801276 | c.468G>T | synonymous_variant | 0.24 | linezolid | |
rplC | 801279 | c.471G>C | synonymous_variant | 0.24 | linezolid | |
rplC | 801285 | c.477G>C | synonymous_variant | 0.22 | linezolid | |
rplC | 801288 | c.480G>C | synonymous_variant | 0.26 | linezolid | |
rplC | 801300 | c.492C>G | synonymous_variant | 0.28 | linezolid | |
rplC | 801309 | c.501C>G | synonymous_variant | 0.31 | linezolid | |
rplC | 801312 | c.504G>C | synonymous_variant | 0.29 | linezolid | |
rplC | 801321 | c.513C>T | synonymous_variant | 0.28 | linezolid | Not assoc w R - Interim |
rplC | 801324 | c.516T>C | synonymous_variant | 0.27 | linezolid | |
rplC | 801339 | c.531T>G | synonymous_variant | 0.21 | linezolid | |
rplC | 801341 | p.Leu178Gln | missense_variant | 0.21 | linezolid | |
rplC | 801348 | c.540T>G | synonymous_variant | 0.2 | linezolid | |
rplC | 801357 | c.549T>C | synonymous_variant | 0.19 | linezolid | |
rplC | 801378 | c.570C>T | synonymous_variant | 0.18 | linezolid | |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
fbiC | 1303584 | c.654C>G | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303590 | c.660A>G | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303605 | c.675C>G | synonymous_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303645 | p.Ala239Gln | missense_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303659 | c.729T>G | synonymous_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303661 | p.Val244Ala | missense_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303686 | c.756C>G | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303695 | c.765T>C | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303755 | c.825T>C | synonymous_variant | 0.17 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304748 | c.1818T>C | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304754 | c.1824G>A | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304757 | c.1827A>G | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304778 | c.1848T>C | synonymous_variant | 0.28 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304784 | c.1854T>G | synonymous_variant | 0.28 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304796 | c.1866G>A | synonymous_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304799 | c.1869G>C | synonymous_variant | 0.37 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304811 | c.1881C>G | synonymous_variant | 0.33 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304817 | c.1887T>C | synonymous_variant | 0.4 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304823 | c.1893C>T | synonymous_variant | 0.38 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304829 | c.1899T>C | synonymous_variant | 0.4 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304832 | c.1902C>T | synonymous_variant | 0.39 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
fbiC | 1304856 | c.1926C>G | synonymous_variant | 0.44 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304875 | p.Ile649Val | missense_variant | 0.45 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304893 | p.Gly655Ser | missense_variant | 0.46 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304915 | p.Asp662Gly | missense_variant | 0.41 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304922 | c.1992C>T | synonymous_variant | 0.39 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304925 | c.1995G>C | synonymous_variant | 0.39 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304928 | c.1998T>C | synonymous_variant | 0.39 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304940 | c.2010A>G | synonymous_variant | 0.41 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304946 | c.2016G>C | synonymous_variant | 0.44 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304958 | c.2028T>G | synonymous_variant | 0.44 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304970 | c.2040G>C | synonymous_variant | 0.45 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304988 | c.2058G>C | synonymous_variant | 0.43 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304994 | c.2064A>G | synonymous_variant | 0.39 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304995 | p.Leu689Met | missense_variant | 0.38 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305006 | p.Glu692Asp | missense_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305009 | c.2079C>A | synonymous_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305013 | p.Thr695Ser | missense_variant | 0.3 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305021 | c.2091C>G | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305033 | c.2103T>C | synonymous_variant | 0.33 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305042 | c.2112A>G | synonymous_variant | 0.29 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305045 | c.2115A>G | synonymous_variant | 0.29 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305066 | c.2136T>C | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305069 | c.2139G>C | synonymous_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305078 | c.2148A>C | synonymous_variant | 0.24 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305092 | p.Ala721Gly | missense_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305099 | c.2169T>C | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
sigE | 1364883 | c.471G>A | synonymous_variant | 0.18 | pyrazinamide | |
sigE | 1364889 | c.477A>G | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
sigE | 1364892 | c.480C>G | synonymous_variant | 0.21 | pyrazinamide | |
sigE | 1364910 | c.498G>C | synonymous_variant | 0.26 | pyrazinamide | |
sigE | 1364913 | c.501C>G | synonymous_variant | 0.27 | pyrazinamide | |
sigE | 1364919 | c.507T>C | synonymous_variant | 0.28 | pyrazinamide | |
sigE | 1364925 | c.513C>G | synonymous_variant | 0.29 | pyrazinamide | |
sigE | 1364931 | c.519C>G | synonymous_variant | 0.32 | pyrazinamide | |
sigE | 1364952 | c.540A>G | synonymous_variant | 0.36 | pyrazinamide | |
sigE | 1364955 | c.543G>C | synonymous_variant | 0.35 | pyrazinamide | |
sigE | 1364961 | c.549A>G | synonymous_variant | 0.35 | pyrazinamide | |
sigE | 1364964 | c.552T>C | synonymous_variant | 0.38 | pyrazinamide | Not assoc w R - Interim |
sigE | 1364976 | c.564T>C | synonymous_variant | 0.35 | pyrazinamide | Not assoc w R - Interim |
sigE | 1364979 | c.567C>G | synonymous_variant | 0.33 | pyrazinamide | |
sigE | 1364980 | c.568T>C | synonymous_variant | 0.33 | pyrazinamide | |
sigE | 1364984 | p.Ala191Asp | missense_variant | 0.33 | pyrazinamide | |
sigE | 1365006 | c.594T>C | synonymous_variant | 0.33 | pyrazinamide | |
sigE | 1365012 | c.600G>C | synonymous_variant | 0.33 | pyrazinamide | |
sigE | 1365024 | c.612T>C | synonymous_variant | 0.29 | pyrazinamide | |
sigE | 1365033 | c.621G>A | synonymous_variant | 0.23 | pyrazinamide | |
sigE | 1365036 | c.624T>C | synonymous_variant | 0.24 | pyrazinamide | |
sigE | 1365042 | c.630G>C | synonymous_variant | 0.23 | pyrazinamide | |
sigE | 1365045 | c.633C>T | synonymous_variant | 0.24 | pyrazinamide | |
Rv1258c | 1406760 | c.580_581insC | frameshift_variant | 1.0 | streptomycin | Uncertain significance |
pyrazinamide | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472445 | n.601_604delTCTC | non_coding_transcript_exon_variant | 0.41 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472451 | n.606_607insCGGG | non_coding_transcript_exon_variant | 0.4 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472460 | n.615T>C | non_coding_transcript_exon_variant | 0.43 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472461 | n.616G>C | non_coding_transcript_exon_variant | 0.43 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472463 | n.618G>C | non_coding_transcript_exon_variant | 0.45 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472464 | n.619A>G | non_coding_transcript_exon_variant | 0.45 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472489 | n.644A>G | non_coding_transcript_exon_variant | 0.51 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473797 | n.140G>T | non_coding_transcript_exon_variant | 0.39 | capreomycin | |
linezolid | ||||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473813 | n.156C>T | non_coding_transcript_exon_variant | 0.45 | capreomycin | |
linezolid | ||||||
rrl | 1473839 | n.182G>T | non_coding_transcript_exon_variant | 0.52 | capreomycin | |
linezolid | ||||||
rrl | 1473877 | n.220G>A | non_coding_transcript_exon_variant | 0.49 | capreomycin | |
linezolid | ||||||
rrl | 1473887 | n.230T>A | non_coding_transcript_exon_variant | 0.52 | capreomycin | |
linezolid | ||||||
rrl | 1473888 | n.231T>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473899 | n.242A>G | non_coding_transcript_exon_variant | 0.54 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473916 | n.259C>A | non_coding_transcript_exon_variant | 0.55 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473937 | n.280C>T | non_coding_transcript_exon_variant | 0.58 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473943 | n.286G>T | non_coding_transcript_exon_variant | 0.56 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474286 | n.629C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1474717 | n.1060A>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.49 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.51 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.56 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.52 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475369 | n.1712G>T | non_coding_transcript_exon_variant | 0.34 | capreomycin | |
linezolid | ||||||
rrl | 1475379 | n.1722G>A | non_coding_transcript_exon_variant | 0.37 | capreomycin | |
linezolid | ||||||
rrl | 1475398 | n.1741C>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1475401 | n.1745delC | non_coding_transcript_exon_variant | 0.39 | capreomycin | |
linezolid | ||||||
rrl | 1475405 | n.1748A>T | non_coding_transcript_exon_variant | 0.39 | capreomycin | |
linezolid | ||||||
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.46 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475429 | n.1772G>A | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475446 | n.1789G>C | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | ||||||
rrl | 1475453 | n.1796T>A | non_coding_transcript_exon_variant | 0.51 | capreomycin | |
linezolid | ||||||
rrl | 1475480 | n.1823A>G | non_coding_transcript_exon_variant | 0.46 | capreomycin | |
linezolid | ||||||
rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475487 | n.1830C>T | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475599 | n.1942A>G | non_coding_transcript_exon_variant | 0.42 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1475604 | n.1947A>C | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475605 | n.1948A>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | |
linezolid | ||||||
rrl | 1475608 | n.1951T>C | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475617 | n.1960C>G | non_coding_transcript_exon_variant | 0.41 | capreomycin | |
linezolid | ||||||
rrl | 1475625 | n.1968G>C | non_coding_transcript_exon_variant | 0.41 | capreomycin | |
linezolid | ||||||
rrl | 1475637 | n.1980T>A | non_coding_transcript_exon_variant | 0.44 | capreomycin | |
linezolid | ||||||
rrl | 1475642 | n.1985T>C | non_coding_transcript_exon_variant | 0.44 | capreomycin | |
linezolid | ||||||
rrl | 1475657 | n.2000A>G | non_coding_transcript_exon_variant | 0.43 | capreomycin | |
linezolid | ||||||
rrl | 1475659 | n.2002G>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475759 | n.2102_2106delCCCGCinsTCGT | non_coding_transcript_exon_variant | 0.65 | capreomycin | |
linezolid | ||||||
rrl | 1475765 | n.2111delG | non_coding_transcript_exon_variant | 0.67 | capreomycin | |
linezolid | ||||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.6 | capreomycin | |
linezolid | ||||||
rrl | 1476580 | n.2923G>A | non_coding_transcript_exon_variant | 0.31 | capreomycin | |
linezolid | ||||||
rrl | 1476595 | n.2938C>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476602 | n.2945G>A | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476608 | n.2951C>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476619 | n.2962C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rpsA | 1833532 | c.-10A>C | upstream_gene_variant | 0.21 | pyrazinamide | |
rpsA | 1833554 | p.Thr5Ala | missense_variant | 0.19 | pyrazinamide | Uncertain significance |
rpsA | 1833589 | c.48A>T | synonymous_variant | 0.29 | pyrazinamide | |
rpsA | 1833595 | c.54T>G | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833667 | c.126C>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1833703 | c.162C>T | synonymous_variant | 0.39 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833724 | c.183C>G | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1833760 | c.219C>T | synonymous_variant | 0.31 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833782 | p.Ser81Thr | missense_variant | 0.33 | pyrazinamide | |
rpsA | 1833787 | c.246C>G | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833793 | c.252C>T | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1833799 | c.258C>A | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833802 | c.261A>G | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833808 | c.267G>T | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833811 | c.270G>T | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1833820 | c.279G>A | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1833832 | c.291G>A | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833838 | c.297G>T | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1833847 | c.306C>G | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1833874 | c.333T>C | synonymous_variant | 0.36 | pyrazinamide | |
rpsA | 1833892 | c.351G>A | synonymous_variant | 0.41 | pyrazinamide | |
rpsA | 1833904 | c.363G>A | synonymous_variant | 0.4 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.37 | pyrazinamide | |
rpsA | 1833949 | c.408T>C | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1833970 | c.429G>C | synonymous_variant | 0.39 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.43 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.41 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834051 | c.510G>A | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1834097 | c.556_557delTCinsAG | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1834102 | c.561T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834105 | c.564C>T | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834177 | c.636A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834186 | c.645C>G | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834189 | c.648G>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834192 | c.651C>G | synonymous_variant | 0.23 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834213 | c.672G>T | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834222 | c.681T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834234 | c.693G>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834249 | c.708T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834252 | c.711C>T | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834258 | c.717G>A | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834259 | c.718_720delCTAinsTTG | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834264 | c.723G>T | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834279 | c.738C>T | synonymous_variant | 0.27 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834282 | c.741C>T | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834294 | c.753G>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.26 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.22 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834387 | c.846C>T | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834414 | c.873C>T | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834417 | c.876G>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834432 | c.891G>C | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1834435 | c.894G>C | synonymous_variant | 0.29 | pyrazinamide | |
rpsA | 1834440 | p.Lys300Met | missense_variant | 0.31 | pyrazinamide | |
rpsA | 1834444 | c.903C>G | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1834465 | c.924T>C | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1834474 | c.933C>G | synonymous_variant | 0.29 | pyrazinamide | |
rpsA | 1834477 | c.936C>T | synonymous_variant | 0.31 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1834495 | c.954G>A | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1834498 | c.957C>T | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834513 | c.972C>G | synonymous_variant | 0.39 | pyrazinamide | |
rpsA | 1834517 | c.976C>T | synonymous_variant | 0.42 | pyrazinamide | |
rpsA | 1834528 | c.987T>C | synonymous_variant | 0.43 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1834555 | c.1014T>C | synonymous_variant | 0.45 | pyrazinamide | |
rpsA | 1834558 | c.1017C>G | synonymous_variant | 0.45 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.46 | pyrazinamide | |
rpsA | 1834612 | c.1071G>A | synonymous_variant | 0.48 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834615 | c.1074C>T | synonymous_variant | 0.49 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.45 | pyrazinamide | |
rpsA | 1834654 | c.1113G>A | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1834666 | c.1125G>C | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1834669 | c.1128G>C | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1834690 | c.1149T>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834732 | c.1191T>C | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1834733 | p.Ala398Ser | missense_variant | 0.34 | pyrazinamide | |
rpsA | 1834747 | c.1206A>G | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1834751 | p.Leu404Ile | missense_variant | 0.3 | pyrazinamide | |
rpsA | 1834756 | c.1215G>A | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834759 | c.1218A>C | synonymous_variant | 0.29 | pyrazinamide | |
rpsA | 1834765 | p.Glu408Asp | missense_variant | 0.29 | pyrazinamide | |
rpsA | 1834767 | p.Lys409Thr | missense_variant | 0.29 | pyrazinamide | |
rpsA | 1834775 | p.Ala412Asn | missense_variant | 0.28 | pyrazinamide | |
rpsA | 1834780 | c.1239A>G | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834786 | c.1245A>G | synonymous_variant | 0.29 | pyrazinamide | |
rpsA | 1834789 | c.1248T>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834792 | c.1251G>C | synonymous_variant | 0.29 | pyrazinamide | |
tsnR | 1853432 | c.-174G>C | upstream_gene_variant | 0.26 | linezolid | |
tsnR | 1853459 | c.-147G>C | upstream_gene_variant | 0.26 | linezolid | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
kasA | 2517941 | c.-174C>G | upstream_gene_variant | 0.22 | isoniazid | |
kasA | 2517950 | c.-165C>G | upstream_gene_variant | 0.22 | isoniazid | |
kasA | 2517962 | c.-153C>G | upstream_gene_variant | 0.24 | isoniazid | |
kasA | 2517989 | c.-126T>C | upstream_gene_variant | 0.24 | isoniazid | |
kasA | 2517993 | c.-122G>T | upstream_gene_variant | 0.23 | isoniazid | |
kasA | 2518010 | c.-105C>G | upstream_gene_variant | 0.27 | isoniazid | |
kasA | 2518013 | c.-102G>A | upstream_gene_variant | 0.25 | isoniazid | |
kasA | 2518019 | c.-96A>G | upstream_gene_variant | 0.24 | isoniazid | |
kasA | 2518025 | c.-90G>C | upstream_gene_variant | 0.23 | isoniazid | |
kasA | 2518031 | c.-84G>T | upstream_gene_variant | 0.23 | isoniazid | |
kasA | 2518034 | c.-81T>C | upstream_gene_variant | 0.22 | isoniazid | |
kasA | 2518035 | c.-80C>G | upstream_gene_variant | 0.22 | isoniazid | |
kasA | 2518041 | c.-74T>C | upstream_gene_variant | 0.22 | isoniazid | |
kasA | 2518049 | c.-66G>C | upstream_gene_variant | 0.22 | isoniazid | |
folC | 2747314 | c.285A>C | synonymous_variant | 0.21 | para-aminosalicylic_acid | |
folC | 2747341 | p.Val86Leu | missense_variant | 0.2 | para-aminosalicylic_acid | |
Rv2477c | 2783203 | c.840C>G | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783278 | c.765A>G | synonymous_variant | 0.28 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783281 | c.762G>T | synonymous_variant | 0.25 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783289 | p.Leu252Ile | missense_variant | 0.29 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783299 | c.744A>G | synonymous_variant | 0.26 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783302 | c.741A>G | synonymous_variant | 0.28 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783311 | c.732T>C | synonymous_variant | 0.28 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783329 | c.714G>A | synonymous_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783332 | c.711T>C | synonymous_variant | 0.33 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783338 | c.705C>T | synonymous_variant | 0.32 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783350 | c.693T>C | synonymous_variant | 0.33 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783353 | c.690T>C | synonymous_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783359 | c.684G>A | synonymous_variant | 0.33 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783374 | c.669G>C | synonymous_variant | 0.38 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783395 | c.648T>C | synonymous_variant | 0.41 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783410 | c.633G>C | synonymous_variant | 0.42 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783422 | c.621T>C | synonymous_variant | 0.46 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783425 | c.618C>G | synonymous_variant | 0.43 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783428 | c.615C>T | synonymous_variant | 0.44 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | ||||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783461 | c.582T>C | synonymous_variant | 0.41 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783464 | c.579A>G | synonymous_variant | 0.36 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783467 | c.576G>C | synonymous_variant | 0.38 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783473 | c.570A>G | synonymous_variant | 0.4 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783491 | c.552C>T | synonymous_variant | 0.42 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783499 | c.544T>C | synonymous_variant | 0.41 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783502 | c.541T>C | synonymous_variant | 0.4 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783512 | c.531A>G | synonymous_variant | 0.48 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783520 | c.523T>C | synonymous_variant | 0.45 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783548 | c.495T>A | synonymous_variant | 0.42 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783554 | c.489C>T | synonymous_variant | 0.44 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783563 | c.480A>G | synonymous_variant | 0.42 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783566 | c.477C>T | synonymous_variant | 0.4 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783572 | c.471A>G | synonymous_variant | 0.39 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783586 | p.Ala153Pro | missense_variant | 0.35 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783593 | c.450T>C | synonymous_variant | 0.36 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783605 | c.438T>C | synonymous_variant | 0.44 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783611 | c.432C>G | synonymous_variant | 0.41 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783620 | c.423C>G | synonymous_variant | 0.44 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783628 | p.Ala139Ser | missense_variant | 0.47 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783650 | c.393C>T | synonymous_variant | 0.43 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783659 | c.384A>G | synonymous_variant | 0.43 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783668 | c.375G>T | synonymous_variant | 0.39 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783674 | c.369T>C | synonymous_variant | 0.38 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783683 | c.360A>G | synonymous_variant | 0.37 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783700 | p.Thr115Ser | missense_variant | 0.37 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783718 | c.325T>C | synonymous_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783719 | c.324A>G | synonymous_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783751 | p.Ile98Val | missense_variant | 0.4 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783752 | c.291G>A | synonymous_variant | 0.41 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783758 | p.Asp95Glu | missense_variant | 0.41 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783761 | c.282G>C | synonymous_variant | 0.42 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783766 | p.Met93Leu | missense_variant | 0.42 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783779 | c.264T>C | synonymous_variant | 0.42 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783797 | p.Asp82Glu | missense_variant | 0.39 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783812 | c.231G>C | synonymous_variant | 0.37 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783815 | c.228A>G | synonymous_variant | 0.36 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783833 | c.210G>C | synonymous_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783836 | c.207C>G | synonymous_variant | 0.36 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783842 | c.201C>T | synonymous_variant | 0.36 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783846 | p.Thr66Asn | missense_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783851 | c.192G>A | synonymous_variant | 0.36 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783857 | c.186C>G | synonymous_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783860 | c.183T>C | synonymous_variant | 0.33 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783883 | c.160T>C | synonymous_variant | 0.28 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783884 | c.159T>A | synonymous_variant | 0.29 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783920 | c.123G>C | synonymous_variant | 0.33 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783956 | p.Tyr29Phe | missense_variant | 0.35 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783967 | c.76T>C | synonymous_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783971 | c.72G>C | synonymous_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783980 | c.63C>G | synonymous_variant | 0.34 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783992 | c.51T>C | synonymous_variant | 0.3 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | ||||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2784016 | c.27G>A | synonymous_variant | 0.25 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2681 | 2997033 | p.Ala99Pro | missense_variant | 0.18 | capreomycin | |
Rv2752c | 3066456 | c.-265A>G | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066465 | c.-274G>C | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066468 | c.-277C>G | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066471 | c.-280A>C | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066474 | c.-283G>C | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066482 | c.-291G>T | upstream_gene_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066504 | c.-313C>G | upstream_gene_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066513 | c.-322C>G | upstream_gene_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066543 | c.-352C>G | upstream_gene_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066549 | c.-358T>C | upstream_gene_variant | 0.34 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066560 | c.-369C>T | upstream_gene_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066561 | c.-370A>T | upstream_gene_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066567 | c.-376C>A | upstream_gene_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066573 | c.-382G>C | upstream_gene_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066579 | c.-388A>G | upstream_gene_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066583 | c.-392C>G | upstream_gene_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066597 | c.-406C>T | upstream_gene_variant | 0.41 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066603 | c.-412A>G | upstream_gene_variant | 0.4 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066617 | c.-426G>A | upstream_gene_variant | 0.4 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066618 | c.-427A>G | upstream_gene_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066633 | c.-442T>C | upstream_gene_variant | 0.4 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066636 | c.-445G>A | upstream_gene_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066644 | c.-453T>C | upstream_gene_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066646 | c.-455C>T | upstream_gene_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066672 | c.-481G>C | upstream_gene_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066676 | c.-485C>T | upstream_gene_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066685 | c.-495_-494delGGinsCC | upstream_gene_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066699 | c.-508C>G | upstream_gene_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
thyX | 3067316 | c.630A>G | synonymous_variant | 0.33 | para-aminosalicylic_acid | |
thyX | 3067325 | c.621A>G | synonymous_variant | 0.29 | para-aminosalicylic_acid | |
thyX | 3067349 | c.597G>C | synonymous_variant | 0.3 | para-aminosalicylic_acid | |
thyX | 3067355 | c.591A>G | synonymous_variant | 0.27 | para-aminosalicylic_acid | |
thyX | 3067360 | p.Ile196Val | missense_variant | 0.29 | para-aminosalicylic_acid | |
thyX | 3067367 | c.579G>C | synonymous_variant | 0.29 | para-aminosalicylic_acid | |
thyX | 3067373 | c.573C>G | synonymous_variant | 0.27 | para-aminosalicylic_acid | |
thyX | 3067382 | c.564C>T | synonymous_variant | 0.26 | para-aminosalicylic_acid | |
thyX | 3067385 | c.561C>G | synonymous_variant | 0.25 | para-aminosalicylic_acid | |
thyX | 3067394 | c.552G>C | synonymous_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067418 | c.528C>G | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyX | 3067436 | c.510C>G | synonymous_variant | 0.21 | para-aminosalicylic_acid | |
thyX | 3067439 | c.507A>G | synonymous_variant | 0.21 | para-aminosalicylic_acid | |
thyA | 3073977 | c.495A>G | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyA | 3073989 | c.483T>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyA | 3074001 | c.471C>G | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
ald | 3086731 | c.-89A>G | upstream_gene_variant | 1.0 | cycloserine | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
lpqB | 3625528 | c.-618G>T | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625537 | c.-627T>C | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625543 | c.-633G>C | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625569 | c.1045T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625570 | c.-660G>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625579 | c.-669A>C | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625582 | c.-672C>T | upstream_gene_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625585 | c.-675G>C | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625592 | p.Ser341Asn | missense_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625594 | c.-684T>C | upstream_gene_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625602 | c.-692T>C | upstream_gene_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625612 | c.-702G>C | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625615 | p.Arg333Gln | missense_variant | 0.34 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625621 | c.-711G>C | upstream_gene_variant | 0.38 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625630 | c.-720C>G | upstream_gene_variant | 0.38 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625633 | p.Asp327Glu | missense_variant | 0.4 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625638 | p.Ala326Ser | missense_variant | 0.4 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625663 | c.-753G>C | upstream_gene_variant | 0.35 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625669 | c.-759G>A | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625693 | c.-783G>T | upstream_gene_variant | 0.4 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625708 | c.906C>T | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625729 | c.885A>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625747 | c.867G>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625755 | p.Ala287Thr | missense_variant | 0.45 | rifampicin | Uncertain significance |
bedaquiline | ||||||
mtrB | 3625762 | c.852A>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625765 | c.849C>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625774 | c.840G>A | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625792 | c.-882G>A | upstream_gene_variant | 0.47 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625804 | c.-896_-894delAGGinsCGA | upstream_gene_variant | 0.41 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625807 | c.807C>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625822 | c.-912C>T | upstream_gene_variant | 0.39 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625846 | c.-936G>C | upstream_gene_variant | 0.34 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625852 | c.762A>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625860 | p.Ala252Ser | missense_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625888 | c.-978G>C | upstream_gene_variant | 0.35 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625909 | c.-999T>C | upstream_gene_variant | 0.34 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625915 | c.699G>A | synonymous_variant | 0.35 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625927 | c.687T>C | synonymous_variant | 0.32 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625930 | c.684C>A | synonymous_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625936 | c.678C>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625942 | c.672C>G | synonymous_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625945 | c.667_669delCTAinsTTG | synonymous_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625951 | c.663A>G | synonymous_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625955 | p.Leu220Ala | missense_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625960 | c.654C>T | synonymous_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625967 | p.Ala216Ile | missense_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625978 | c.636T>C | synonymous_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626562 | p.Pro18Ser | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
mtrB | 3626783 | c.-170C>G | upstream_gene_variant | 0.24 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626786 | c.564A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626795 | c.-182C>T | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626798 | c.-185T>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626804 | c.546A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626819 | c.-206G>A | upstream_gene_variant | 0.34 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626846 | c.504G>A | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626852 | c.-239G>A | upstream_gene_variant | 0.32 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626857 | c.-244T>C | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626858 | c.-245A>G | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626866 | c.-253T>C | upstream_gene_variant | 0.35 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626876 | c.-263A>G | upstream_gene_variant | 0.38 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626885 | c.-272A>C | upstream_gene_variant | 0.38 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626890 | c.-277T>C | upstream_gene_variant | 0.38 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626903 | c.-290T>C | upstream_gene_variant | 0.4 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626912 | c.438T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626930 | c.-317A>G | upstream_gene_variant | 0.42 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626939 | c.411A>G | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626942 | c.-329A>C | upstream_gene_variant | 0.46 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626954 | c.-341C>G | upstream_gene_variant | 0.5 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626957 | c.-344G>C | upstream_gene_variant | 0.49 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626969 | c.-356C>G | upstream_gene_variant | 0.53 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626972 | c.-359A>G | upstream_gene_variant | 0.53 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626987 | c.-374C>G | upstream_gene_variant | 0.53 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627008 | c.-395G>C | upstream_gene_variant | 0.53 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627011 | c.-398T>G | upstream_gene_variant | 0.53 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627065 | c.-452G>C | upstream_gene_variant | 0.47 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627068 | c.282T>C | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627071 | c.-458G>C | upstream_gene_variant | 0.47 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627098 | c.252A>C | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627104 | c.-491C>G | upstream_gene_variant | 0.41 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627113 | c.-500C>T | upstream_gene_variant | 0.35 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627122 | c.-509T>C | upstream_gene_variant | 0.32 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627175 | c.175C>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627181 | c.-568T>C | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627182 | c.-569T>C | upstream_gene_variant | 0.24 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627185 | c.-574_-572delTTGinsCTT | upstream_gene_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627188 | c.-577_-575delTTAinsCTG | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627197 | c.-584T>C | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627203 | c.-590C>G | upstream_gene_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
rpoA | 3877587 | c.921A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877613 | p.Ile299Val | missense_variant | 0.3 | rifampicin | |
rpoA | 3877617 | c.891G>C | synonymous_variant | 0.32 | rifampicin | |
rpoA | 3877638 | c.870T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3877656 | c.852T>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoA | 3877668 | c.840A>G | synonymous_variant | 0.3 | rifampicin | |
rpoA | 3877677 | p.Ala277Ser | missense_variant | 0.27 | rifampicin | |
rpoA | 3877680 | c.828G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoA | 3877686 | c.822A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoA | 3877692 | c.816G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3877704 | c.804G>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3877710 | c.798C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877737 | c.771G>C | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3877752 | c.756C>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoA | 3877764 | c.744C>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoA | 3877770 | c.738A>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoA | 3877773 | c.735G>C | synonymous_variant | 0.31 | rifampicin | |
rpoA | 3877776 | c.732T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3877782 | c.726T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoA | 3877818 | c.690A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3877839 | c.669G>T | synonymous_variant | 0.31 | rifampicin | |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.34 | rifampicin | |
rpoA | 3877866 | c.642G>C | synonymous_variant | 0.34 | rifampicin | |
rpoA | 3877872 | c.636C>T | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3877875 | c.633T>G | synonymous_variant | 0.35 | rifampicin | |
rpoA | 3877887 | c.621G>C | synonymous_variant | 0.33 | rifampicin | |
rpoA | 3877896 | c.612G>C | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3877900 | p.Ser203Thr | missense_variant | 0.25 | rifampicin | |
rpoA | 3877905 | c.603A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877909 | p.Asn200Ser | missense_variant | 0.27 | rifampicin | |
rpoA | 3877920 | c.588G>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3877956 | p.Glu184Asp | missense_variant | 0.67 | rifampicin | Uncertain significance |
rpoA | 3877986 | c.522G>C | synonymous_variant | 0.36 | rifampicin | |
rpoA | 3877989 | c.519A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3878001 | c.507A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3878022 | c.486T>C | synonymous_variant | 0.32 | rifampicin | |
rpoA | 3878025 | c.483C>T | synonymous_variant | 0.29 | rifampicin | |
rpoA | 3878028 | c.480G>C | synonymous_variant | 0.29 | rifampicin | |
rpoA | 3878031 | c.477T>C | synonymous_variant | 0.3 | rifampicin | |
rpoA | 3878043 | c.465G>C | synonymous_variant | 0.31 | rifampicin | |
rpoA | 3878049 | c.459G>C | synonymous_variant | 0.31 | rifampicin | |
rpoA | 3878055 | c.453A>G | synonymous_variant | 0.31 | rifampicin | |
rpoA | 3878061 | c.447G>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878067 | c.441C>G | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878070 | c.438T>C | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878073 | c.435C>T | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878076 | c.432C>T | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3878079 | c.429C>T | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoA | 3878094 | c.414C>T | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878106 | c.402G>C | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878118 | c.390T>C | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878247 | c.261G>C | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878256 | c.252G>C | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878262 | p.Ser82Gly | missense_variant | 0.25 | rifampicin | |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3878283 | p.Glu75Asp | missense_variant | 0.33 | rifampicin | Uncertain significance |
rpoA | 3878295 | c.213A>G | synonymous_variant | 0.34 | rifampicin | |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>C | synonymous_variant | 0.42 | rifampicin | |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoA | 3878334 | c.174T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoA | 3878355 | c.153C>G | synonymous_variant | 0.53 | rifampicin | |
rpoA | 3878364 | c.144A>C | synonymous_variant | 0.52 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.51 | rifampicin | |
rpoA | 3878391 | c.117T>G | synonymous_variant | 0.53 | rifampicin | Not assoc w R - Interim |
rpoA | 3878406 | c.102G>T | synonymous_variant | 0.55 | rifampicin | |
rpoA | 3878415 | c.93C>T | synonymous_variant | 0.53 | rifampicin | |
rpoA | 3878421 | c.87A>T | synonymous_variant | 0.56 | rifampicin | |
rpoA | 3878442 | c.66G>C | synonymous_variant | 0.56 | rifampicin | |
rpoA | 3878454 | c.54A>G | synonymous_variant | 0.55 | rifampicin | |
rpoA | 3878458 | p.Asn17Ser | missense_variant | 0.49 | rifampicin | |
rpoA | 3878471 | p.Val13Ile | missense_variant | 0.43 | rifampicin | |
rpoA | 3878472 | p.Asp12Glu | missense_variant | 0.43 | rifampicin | |
rpoA | 3878713 | c.-206G>A | upstream_gene_variant | 0.36 | rifampicin | Uncertain significance |
rpoA | 3878725 | c.-220_-218delCTAinsTTG | upstream_gene_variant | 0.32 | rifampicin | |
rpoA | 3878728 | c.-221G>A | upstream_gene_variant | 0.32 | rifampicin | |
rpoA | 3878734 | c.-229_-227delATCinsGTG | upstream_gene_variant | 0.31 | rifampicin | |
rpoA | 3878737 | c.-230G>C | upstream_gene_variant | 0.3 | rifampicin | |
rpoA | 3878742 | c.-235G>A | upstream_gene_variant | 0.35 | rifampicin | |
rpoA | 3878746 | c.-239A>G | upstream_gene_variant | 0.34 | rifampicin | Uncertain significance |
rpoA | 3878749 | c.-242G>T | upstream_gene_variant | 0.34 | rifampicin | |
rpoA | 3878755 | c.-248G>T | upstream_gene_variant | 0.32 | rifampicin | |
rpoA | 3878764 | c.-257A>G | upstream_gene_variant | 0.37 | rifampicin | |
rpoA | 3878788 | c.-281G>C | upstream_gene_variant | 0.39 | rifampicin | Uncertain significance |
rpoA | 3878806 | c.-299C>G | upstream_gene_variant | 0.4 | rifampicin | |
rpoA | 3878809 | c.-302T>C | upstream_gene_variant | 0.41 | rifampicin | |
rpoA | 3878818 | c.-311G>C | upstream_gene_variant | 0.47 | rifampicin | |
rpoA | 3878833 | c.-326C>G | upstream_gene_variant | 0.46 | rifampicin | |
rpoA | 3878837 | c.-331_-330delAAinsGG | upstream_gene_variant | 0.47 | rifampicin | |
rpoA | 3878853 | c.-346G>A | upstream_gene_variant | 0.51 | rifampicin | |
rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 0.42 | rifampicin | Uncertain significance |
rpoA | 3878884 | c.-377C>G | upstream_gene_variant | 0.49 | rifampicin | |
rpoA | 3878909 | c.-402A>G | upstream_gene_variant | 0.47 | rifampicin | |
rpoA | 3878914 | c.-407T>C | upstream_gene_variant | 0.44 | rifampicin | Uncertain significance |
rpoA | 3878938 | c.-431T>C | upstream_gene_variant | 0.43 | rifampicin | |
rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 0.38 | rifampicin | Uncertain significance |
rpoA | 3878968 | c.-461T>C | upstream_gene_variant | 0.36 | rifampicin | Uncertain significance |
rpoA | 3878974 | c.-469_-467delATCinsGTG | upstream_gene_variant | 0.35 | rifampicin | |
rpoA | 3878991 | c.-484C>A | upstream_gene_variant | 0.4 | rifampicin | |
rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 0.42 | rifampicin | Uncertain significance |
rpoA | 3879006 | c.-499A>C | upstream_gene_variant | 0.43 | rifampicin | |
rpoA | 3879013 | c.-508_-506delGAAinsAAC | upstream_gene_variant | 0.44 | rifampicin | |
rpoA | 3879016 | c.-509A>G | upstream_gene_variant | 0.46 | rifampicin | |
rpoA | 3879022 | c.-515G>C | upstream_gene_variant | 0.49 | rifampicin | |
rpoA | 3879033 | c.-526C>A | upstream_gene_variant | 0.47 | rifampicin | |
rpoA | 3879034 | c.-527G>C | upstream_gene_variant | 0.49 | rifampicin | |
rpoA | 3879037 | c.-530G>C | upstream_gene_variant | 0.49 | rifampicin | |
rpoA | 3879061 | c.-554C>T | upstream_gene_variant | 0.48 | rifampicin | |
rpoA | 3879079 | c.-572A>G | upstream_gene_variant | 0.51 | rifampicin | |
rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.53 | rifampicin | |
rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.54 | rifampicin | |
rpoA | 3879121 | c.-614T>G | upstream_gene_variant | 0.52 | rifampicin | |
rpoA | 3879127 | c.-620T>C | upstream_gene_variant | 0.52 | rifampicin | |
rpoA | 3879154 | c.-647T>C | upstream_gene_variant | 0.42 | rifampicin | |
rpoA | 3879160 | c.-653A>G | upstream_gene_variant | 0.41 | rifampicin | |
rpoA | 3879222 | c.-715T>C | upstream_gene_variant | 0.28 | rifampicin | |
rpoA | 3879226 | c.-719G>C | upstream_gene_variant | 0.26 | rifampicin | |
rpoA | 3879229 | c.-722A>G | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3879238 | c.-731C>G | upstream_gene_variant | 0.21 | rifampicin | |
ddn | 3986636 | c.-208C>G | upstream_gene_variant | 0.19 | pretomanid | |
delamanid | ||||||
ddn | 3986665 | c.-179G>C | upstream_gene_variant | 0.16 | pretomanid | |
delamanid | ||||||
ddn | 3986667 | c.-177_-176delCTinsAC | upstream_gene_variant | 0.18 | pretomanid | |
delamanid | ||||||
ddn | 3986681 | c.-163C>G | upstream_gene_variant | 0.21 | pretomanid | |
delamanid | ||||||
clpC1 | 4038374 | c.2331C>T | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038388 | c.2317T>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4038395 | c.2310C>T | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4038398 | c.2307G>T | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4038403 | c.2302T>C | synonymous_variant | 0.23 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038419 | c.2286T>C | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4038422 | c.2283G>A | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4038428 | c.2277G>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4038433 | c.2272C>T | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4038436 | p.Ala757Ser | missense_variant | 0.24 | pyrazinamide | |
clpC1 | 4038444 | p.Ala754Lys | missense_variant | 0.23 | pyrazinamide | |
clpC1 | 4038446 | c.2259T>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4038456 | p.Val750Glu | missense_variant | 0.25 | pyrazinamide | |
clpC1 | 4038530 | p.Glu725Asp | missense_variant | 0.29 | pyrazinamide | |
clpC1 | 4038536 | c.2169C>T | synonymous_variant | 0.29 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038596 | c.2109A>G | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4038623 | c.2082A>G | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4038647 | c.2058T>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4038658 | p.Lys683Gln | missense_variant | 0.27 | pyrazinamide | |
clpC1 | 4038661 | p.Ser682Thr | missense_variant | 0.26 | pyrazinamide | |
clpC1 | 4038662 | c.2043T>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4038671 | c.2034T>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4038674 | c.2031C>G | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4038683 | c.2022T>C | synonymous_variant | 0.28 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038692 | c.2013C>G | synonymous_variant | 0.28 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038695 | c.2010C>G | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038698 | c.2007C>T | synonymous_variant | 0.29 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038701 | c.2004G>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038704 | c.2001T>C | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4038713 | c.1992T>C | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.37 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.34 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.35 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.39 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>A | synonymous_variant | 0.39 | pyrazinamide | |
clpC1 | 4038821 | c.1884G>A | synonymous_variant | 0.37 | pyrazinamide | |
clpC1 | 4038845 | c.1860G>C | synonymous_variant | 0.39 | pyrazinamide | |
clpC1 | 4038860 | c.1845G>C | synonymous_variant | 0.42 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.35 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038881 | c.1824C>T | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4038890 | c.1815G>A | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.34 | pyrazinamide | |
clpC1 | 4038917 | c.1788C>T | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4038923 | c.1780_1782delCTAinsTTG | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038971 | c.1734T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.22 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039043 | c.1662G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039085 | c.1620A>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039097 | c.1608G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039103 | c.1602T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039121 | c.1584T>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039133 | c.1572C>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039136 | c.1569C>T | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039140 | p.Glu522Val | missense_variant | 0.2 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039145 | c.1560G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039148 | c.1557C>T | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039183 | c.1522T>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039187 | c.1518G>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039190 | c.1515C>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039238 | c.1467C>T | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039319 | p.Ala462Thr | missense_variant | 0.26 | pyrazinamide | |
clpC1 | 4039322 | c.1383T>G | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039328 | c.1377A>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039338 | p.Thr456Gln | missense_variant | 0.27 | pyrazinamide | |
panD | 4044737 | c.-456T>C | upstream_gene_variant | 0.18 | pyrazinamide | |
panD | 4044747 | c.-466T>C | upstream_gene_variant | 0.18 | pyrazinamide | |
panD | 4044749 | c.-468G>C | upstream_gene_variant | 0.18 | pyrazinamide | |
panD | 4044752 | c.-471T>C | upstream_gene_variant | 0.17 | pyrazinamide | |
panD | 4044779 | c.-500_-498delCTAinsTGC | upstream_gene_variant | 0.18 | pyrazinamide | |
panD | 4044785 | c.-504C>G | upstream_gene_variant | 0.18 | pyrazinamide | |
panD | 4044788 | c.-507G>A | upstream_gene_variant | 0.19 | pyrazinamide | |
panD | 4044800 | c.-519C>G | upstream_gene_variant | 0.18 | pyrazinamide | |
panD | 4044809 | c.-528C>G | upstream_gene_variant | 0.19 | pyrazinamide | |
panD | 4044820 | c.-539C>T | upstream_gene_variant | 0.19 | pyrazinamide | |
panD | 4044822 | c.-541G>C | upstream_gene_variant | 0.18 | pyrazinamide | |
panD | 4044824 | c.-543C>T | upstream_gene_variant | 0.18 | pyrazinamide | |
panD | 4044837 | c.-556C>G | upstream_gene_variant | 0.18 | pyrazinamide | |
embC | 4240726 | c.864G>C | synonymous_variant | 0.27 | ethambutol | Not assoc w R - Interim |
embC | 4240759 | c.897C>G | synonymous_variant | 0.25 | ethambutol | |
embC | 4240783 | c.921G>C | synonymous_variant | 0.26 | ethambutol | |
embC | 4240789 | c.927T>C | synonymous_variant | 0.25 | ethambutol | |
embC | 4240811 | p.Phe317Leu | missense_variant | 0.27 | ethambutol | |
embC | 4240819 | c.957A>G | synonymous_variant | 0.27 | ethambutol | |
embC | 4240831 | c.969T>G | synonymous_variant | 0.35 | ethambutol | |
embC | 4240837 | c.975C>G | synonymous_variant | 0.35 | ethambutol | |
embC | 4240859 | p.Leu333Ile | missense_variant | 0.31 | ethambutol | |
embC | 4240867 | c.1005T>G | synonymous_variant | 0.3 | ethambutol | |
embC | 4240870 | c.1008T>C | synonymous_variant | 0.31 | ethambutol | |
embC | 4240879 | c.1017G>C | synonymous_variant | 0.32 | ethambutol | |
embC | 4240880 | p.Ala340Ser | missense_variant | 0.32 | ethambutol | |
embC | 4240885 | c.1023T>C | synonymous_variant | 0.3 | ethambutol | |
embC | 4240897 | c.1035C>G | synonymous_variant | 0.27 | ethambutol | Not assoc w R |
embC | 4240900 | c.1038A>G | synonymous_variant | 0.27 | ethambutol | |
embC | 4240918 | c.1056G>C | synonymous_variant | 0.24 | ethambutol | |
embC | 4240921 | c.1059C>G | synonymous_variant | 0.24 | ethambutol | |
embC | 4240927 | c.1065C>T | synonymous_variant | 0.23 | ethambutol | |
embC | 4240935 | p.Val358Ala | missense_variant | 0.21 | ethambutol | Uncertain significance |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embA | 4243346 | c.114A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
embA | 4243460 | c.228C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4248046 | p.Lys511Asn | missense_variant | 0.19 | ethambutol | |
embB | 4248055 | c.1542G>C | synonymous_variant | 0.19 | ethambutol | |
embB | 4248064 | c.1551G>C | synonymous_variant | 0.2 | ethambutol | Not assoc w R - Interim |
embB | 4248085 | c.1572T>C | synonymous_variant | 0.2 | ethambutol | |
embB | 4248097 | c.1584C>G | synonymous_variant | 0.17 | ethambutol | |
embB | 4248157 | c.1644A>G | synonymous_variant | 0.21 | ethambutol | Not assoc w R - Interim |
embB | 4248173 | p.Val554Leu | missense_variant | 0.24 | ethambutol | |
embB | 4248199 | c.1686A>C | synonymous_variant | 0.28 | ethambutol | |
embB | 4248200 | p.Ile563Val | missense_variant | 0.27 | ethambutol | |
embB | 4248206 | p.Ser565Gly | missense_variant | 0.28 | ethambutol | Uncertain significance |
embB | 4248211 | c.1698G>C | synonymous_variant | 0.26 | ethambutol | |
embB | 4248220 | c.1707A>G | synonymous_variant | 0.27 | ethambutol | Not assoc w R - Interim |
embB | 4248226 | c.1713G>C | synonymous_variant | 0.29 | ethambutol | |
embB | 4248232 | c.1719G>A | synonymous_variant | 0.26 | ethambutol | Not assoc w R - Interim |
embB | 4248233 | c.1720C>T | synonymous_variant | 0.26 | ethambutol | |
embB | 4248241 | c.1728C>T | synonymous_variant | 0.31 | ethambutol | |
embB | 4248277 | c.1764G>C | synonymous_variant | 0.4 | ethambutol | |
embB | 4248280 | c.1767C>G | synonymous_variant | 0.36 | ethambutol | |
embB | 4248316 | c.1803C>G | synonymous_variant | 0.24 | ethambutol | |
embB | 4248322 | c.1809G>C | synonymous_variant | 0.27 | ethambutol | |
embB | 4248328 | c.1815G>C | synonymous_variant | 0.29 | ethambutol | |
embB | 4248337 | c.1824G>C | synonymous_variant | 0.23 | ethambutol | |
embB | 4248350 | c.1837T>C | synonymous_variant | 0.21 | ethambutol | |
embB | 4248355 | c.1842A>G | synonymous_variant | 0.21 | ethambutol | |
embB | 4248358 | c.1845C>G | synonymous_variant | 0.2 | ethambutol | |
embB | 4248361 | c.1848A>G | synonymous_variant | 0.21 | ethambutol | Not assoc w R - Interim |
embB | 4248362 | p.Ser617Lys | missense_variant | 0.21 | ethambutol | |
embB | 4248388 | c.1875G>C | synonymous_variant | 0.16 | ethambutol | |
aftB | 4267647 | p.Asp397Gly | missense_variant | 0.95 | ethambutol | Not assoc w R |
whiB6 | 4338371 | p.Thr51Pro | missense_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
gid | 4407927 | p.Glu92Asp | missense_variant | 1.0 | streptomycin | Not assoc w R |