TB-Profiler result

Run: ERR4800527
Summary

Run ID: ERR4800527

Sample name:

Date: 2024-04-15T13:58:19.416723

Number of reads: 3837147

Percentage reads mapped: 77.92

Median coverage: 110.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.96
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.97
lineage2.2 East-Asian (Beijing) RD105;RD207 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
pyrazinamide pncA p.Ile133Thr Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide ethA p.Gln271* Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1945_1947delATTinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
p.Leu689* Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.7 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.81 streptomycin Assoc w R
fbiC 1304875 c.1945_1947delATTinsGG frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304996 p.Leu689* stop_gained 0.14 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155168 p.Ser315Thr missense_variant 0.98 isoniazid Assoc w R High-level resistance
pncA 2288844 p.Ile133Thr missense_variant 0.97 pyrazinamide Assoc w R
embB 4247429 p.Met306Val missense_variant 0.86 ethambutol Assoc w R
ethA 4326663 p.Gln271* stop_gained 0.96 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1024 c.1024T>C synonymous_variant 0.17 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.16 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.16 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.18 isoniazid
gyrB 6214 c.975G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Asn missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6274 c.1035C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7463 c.162G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7490 c.189C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7496 c.195C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8324 c.1023T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.18 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8510 c.1209G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8561 c.1260A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8591 c.1290C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8678 c.1377G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491121 c.339A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491133 c.351A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491290 p.Val170Met missense_variant 0.9 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.17 ethionamide
isoniazid
mshA 575728 c.381C>T synonymous_variant 0.18 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.17 ethionamide
isoniazid
mshA 575771 p.Val142Phe missense_variant 0.15 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575786 p.Tyr147His missense_variant 0.16 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.16 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575902 c.555C>T synonymous_variant 0.15 ethionamide
isoniazid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 0.85 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620245 p.Leu119Met missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Leu missense_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>T synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620269 p.Val127Phe missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>T synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620319 c.429C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.15 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620625 p.Ile245Met missense_variant 0.97 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620664 c.774C>T synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAC frameshift_variant&missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620758 c.868_870delCGCinsAG frameshift_variant&missense_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620766 c.876C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620823 c.933C>T synonymous_variant 0.13 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 0.96 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.93 ethionamide Uncertain significance
Rv0565c 657337 p.Arg45Gln missense_variant 0.14 ethionamide Uncertain significance
hadA 732398 p.Ala157Thr missense_variant 0.16 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.16 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.17 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.18 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.17 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.18 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.19 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.18 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760534 p.Val243Asp missense_variant 0.16 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760567 p.Ser254Trp missense_variant 0.17 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.16 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.2 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.19 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.18 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.17 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.18 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.18 rifampicin
rpoB 760781 c.975G>C synonymous_variant 0.16 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.23 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.26 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.37 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.36 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.35 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.31 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.28 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.24 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.22 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.21 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.21 rifampicin
rpoB 761373 p.Val523His missense_variant 0.18 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.21 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.2 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.19 rifampicin
rpoB 761439 p.Asp545Ser missense_variant 0.19 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.19 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.19 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.19 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.19 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.16 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.15 rifampicin
rpoB 761636 c.1830G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.16 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.15 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.15 rifampicin
rpoB 761815 p.Ala670Asp missense_variant 0.15 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.16 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.15 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.16 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.19 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.18 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.16 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.18 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.26 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.21 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.2 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.18 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.18 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.24 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.24 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.23 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.17 rifampicin
rpoC 762446 c.-924C>G upstream_gene_variant 0.18 rifampicin
rpoB 762789 p.Leu995Met missense_variant 0.15 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.17 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.16 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763034 c.-336C>A upstream_gene_variant 0.15 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.17 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.17 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.16 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.17 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>G synonymous_variant 0.16 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.17 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.22 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.24 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.23 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.22 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.21 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.2 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.2 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.19 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.18 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.19 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.19 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.17 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.17 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.17 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.16 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.17 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.17 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.17 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.16 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.17 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.18 rifampicin
rpoC 763951 c.582G>T synonymous_variant 0.17 rifampicin
rpoC 763960 c.591T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763991 p.Ile208Leu missense_variant 0.16 rifampicin
rpoC 763996 c.627T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764005 c.636G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.17 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.17 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.17 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.18 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.22 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.23 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.21 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.18 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.19 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.22 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.18 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.18 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764290 c.921C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>G synonymous_variant 0.19 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.16 rifampicin
rpoC 764585 c.1216_1218delCTCinsTG frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.21 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>G synonymous_variant 0.24 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.21 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.23 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.23 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.24 rifampicin
rpoC 764916 p.Leu516Pro missense_variant 0.73 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.19 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.17 rifampicin
rpoC 765034 c.1665T>G synonymous_variant 0.15 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.19 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.17 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.18 rifampicin
rpoC 765649 c.2280C>T synonymous_variant 0.16 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.16 rifampicin
rpoC 765752 p.Asp795Ser missense_variant 0.16 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.19 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.18 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.17 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.18 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.17 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.17 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.16 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.16 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.17 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.17 rifampicin
rpoC 766279 c.2910C>G synonymous_variant 0.16 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.18 rifampicin
rpoC 766300 c.2931C>G synonymous_variant 0.17 rifampicin
rpoC 766312 c.2943T>G synonymous_variant 0.19 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.19 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.17 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.18 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.17 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.18 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.22 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.22 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766393 c.3024C>G synonymous_variant 0.24 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.25 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.24 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.24 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.21 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.21 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.21 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.25 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.22 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.21 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.21 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.21 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.18 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.17 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.18 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.2 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.2 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.22 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.2 rifampicin
rpoC 766651 c.3282T>G synonymous_variant 0.19 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.2 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.22 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.23 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.23 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.21 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.2 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.21 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.18 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.16 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.19 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.16 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.14 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 0.97 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.18 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.2 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.21 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.21 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.22 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.22 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.19 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.19 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.19 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.19 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.18 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.17 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>G synonymous_variant 0.17 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.16 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.16 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.16 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.17 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.18 streptomycin Uncertain significance
rplC 800558 c.-251G>A upstream_gene_variant 0.15 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.16 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.17 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.24 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.22 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.19 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.16 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.16 linezolid
rplC 801195 c.387G>C synonymous_variant 0.16 linezolid
Rv1129c 1253930 p.Phe202Tyr missense_variant 0.98 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1304520 c.1590A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304530 p.Ser534Ala missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304538 c.1608C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304546 p.Val539Ala missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>T synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304826 c.1896G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304991 c.2061G>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1305006 p.Glu692Asp missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1305331 p.Glu801Lys missense_variant 0.13 clofazimine
pretomanid
delamanid
Rv1258c 1406760 c.580_581insC frameshift_variant 0.99 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472445 n.601_604delTCTC non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472451 n.606_607insCGGG non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474071 n.414G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474952 n.1296_1300delCATCC non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474962 n.1305T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474967 n.1311_1315delGGGTG non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474995 n.1338T>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475005 n.1348C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475027 n.1370G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475028 n.1371G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475387 n.1730C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid Uncertain significance
rrl 1475603 n.1946G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674542 p.Ala114Glu missense_variant 0.14 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.22 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674639 c.438C>G synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674663 c.462G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674750 c.549T>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674759 c.558G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674780 c.579T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674783 c.582C>T synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674790 c.589C>T synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674799 c.598_600delAGTinsTCG synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.15 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.15 ethionamide
isoniazid
rpsA 1833940 c.399C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833949 c.408T>G synonymous_variant 0.17 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.15 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834351 c.810G>A synonymous_variant 0.27 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.25 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>G synonymous_variant 0.27 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834684 c.1143C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834759 c.1218A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834767 p.Lys409Thr missense_variant 0.17 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.18 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.17 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.15 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.16 isoniazid
kasA 2518187 p.Ile25Val missense_variant 0.17 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.17 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.18 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.19 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.22 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.15 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.15 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.17 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.18 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.18 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.17 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.18 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.18 isoniazid
kasA 2518594 c.480C>G synonymous_variant 0.17 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.2 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.22 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.19 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.16 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.17 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.17 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.18 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.18 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.16 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.16 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.16 isoniazid
kasA 2518765 c.651G>C synonymous_variant 0.17 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.17 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.17 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.17 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.14 isoniazid
Rv2477c 2783040 p.Ala335Thr missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783152 c.891G>A synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783842 c.201C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783854 c.189C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3066087 c.105A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066150 c.42C>T synonymous_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067316 c.630A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067321 c.625C>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067334 c.612C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067823 c.123G>C synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.99 pyrazinamide Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.15 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625528 c.-618G>T upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625534 c.-624C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.19 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625792 c.-882G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 0.16 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626924 c.-311G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.17 bedaquiline
rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>C synonymous_variant 0.19 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877847 c.661C>T synonymous_variant 0.15 rifampicin
rpoA 3877848 c.660C>G synonymous_variant 0.16 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.17 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877899 p.Ser203Thr missense_variant 0.19 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.18 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.18 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.17 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878157 c.351C>G synonymous_variant 0.18 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.17 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.23 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.22 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878309 p.Pro67Ala missense_variant 0.17 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.17 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.18 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.2 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.18 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.19 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.19 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.19 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.19 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.19 rifampicin
rpoA 3878430 c.78G>C synonymous_variant 0.17 rifampicin
rpoA 3878433 c.75G>C synonymous_variant 0.17 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.17 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.17 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.2 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.19 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.15 rifampicin
rpoA 3878722 c.-215C>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878725 c.-218A>C upstream_gene_variant 0.15 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.18 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.19 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.24 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.25 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.27 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.3 rifampicin
rpoA 3878833 c.-326C>A upstream_gene_variant 0.23 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.21 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.25 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.25 rifampicin
rpoA 3878950 c.-443C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878959 c.-452G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.28 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.23 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.24 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.26 rifampicin
rpoA 3879043 c.-536C>G upstream_gene_variant 0.26 rifampicin
rpoA 3879079 c.-572A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.23 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879115 c.-608G>A upstream_gene_variant 0.22 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.2 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.15 rifampicin
clpC1 4038653 c.2052C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.15 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.15 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038698 c.2007C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038713 c.1992T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038884 c.1821C>T synonymous_variant 0.28 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039043 c.1662G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039166 c.1539G>A synonymous_variant 0.15 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039316 c.1389G>A synonymous_variant 0.23 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.23 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.2 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039582 p.Thr375Ser missense_variant 0.19 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039760 c.945T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.16 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039930 p.Ser259Cys missense_variant 0.15 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.22 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.24 pyrazinamide
clpC1 4040108 c.597G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040129 c.576C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040180 c.525C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.18 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040278 p.Ser143Thr missense_variant 0.15 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040335 c.370C>T synonymous_variant 0.19 pyrazinamide
glpK 4138634 c.1122G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138640 c.1116C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138696 p.Pro354Ala missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138754 c.1002C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4241022 p.Ala387Val missense_variant 0.93 ethambutol Uncertain significance
embC 4241071 c.1209C>G synonymous_variant 0.17 ethambutol
embC 4241074 c.1212G>C synonymous_variant 0.16 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.19 ethambutol
embC 4241116 c.1254C>G synonymous_variant 0.19 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Ala missense_variant 0.17 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.17 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248001 c.1488C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.16 ethambutol
embB 4248169 c.1656C>G synonymous_variant 0.15 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.15 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.99 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 0.95 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R