TB-Profiler result

Run: ERR4818646
Summary

Run ID: ERR4818646

Sample name:

Date: 2024-10-04T23:12:23.195666

Number of reads: 1183903

Percentage reads mapped: 22.19

Median coverage: 22.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 1.0
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6286 c.1047T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6302 p.Ala355Thr missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6307 c.1068T>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6308 p.Val357Ile missense_variant 0.34 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6323 p.Val362Leu missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
mshA 575679 p.Asn111Ser missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
rpoB 760115 c.309C>T synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 760997 c.1191G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761064 p.Ala420Ser missense_variant 0.76 rifampicin Uncertain significance
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.66 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.66 rifampicin
rpoB 761129 c.1323G>T synonymous_variant 0.57 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761138 c.1332C>G synonymous_variant 0.5 rifampicin
rpoB 761147 c.1341C>G synonymous_variant 0.46 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761156 c.1350G>C synonymous_variant 0.44 rifampicin
rpoB 761162 c.1356G>C synonymous_variant 0.42 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761622 p.Gln606Met missense_variant 0.48 rifampicin
rpoB 761633 c.1827G>C synonymous_variant 0.44 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762002 c.2196C>G synonymous_variant 0.42 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.42 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762015 p.Glu737Gln missense_variant 0.45 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.45 rifampicin
rpoB 762026 c.2220G>C synonymous_variant 0.51 rifampicin
rpoB 762030 p.Thr742Ser missense_variant 0.51 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.49 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762068 c.2262C>T synonymous_variant 0.46 rifampicin
rpoB 762080 c.2274G>C synonymous_variant 0.32 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762084 p.Ala760Pro missense_variant 0.31 rifampicin
rpoB 762098 c.2292C>T synonymous_variant 0.35 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.48 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.61 rifampicin
rpoB 762128 c.2322G>C synonymous_variant 0.65 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.58 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.58 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.65 rifampicin
rpoB 762161 c.2355C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762175 c.2369_2370insCG frameshift_variant 0.67 rifampicin
rpoB 762179 c.2374_2375delGA frameshift_variant 0.61 rifampicin
rpoB 762185 c.2379G>T synonymous_variant 0.66 rifampicin
rpoB 762194 c.2388G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>T synonymous_variant 0.61 rifampicin
rpoB 762251 c.2445G>C synonymous_variant 0.61 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.6 rifampicin
rpoB 762278 c.2472C>T synonymous_variant 0.6 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762287 c.2481C>T synonymous_variant 0.56 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762849 p.Tyr1015Asp missense_variant 0.24 rifampicin
rpoB 762855 p.Val1017Ile missense_variant 0.3 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.33 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762866 c.-504C>G upstream_gene_variant 0.42 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.53 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762909 p.Ile1035Leu missense_variant 0.56 rifampicin
rpoB 762923 c.3117C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.32 rifampicin
rpoC 763013 c.-357C>A upstream_gene_variant 0.27 rifampicin
rpoB 763014 p.Met1070Leu missense_variant 0.28 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.28 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.45 rifampicin Not assoc w R
rpoB 763038 p.Thr1078Ala missense_variant 0.44 rifampicin
rpoC 763043 c.-327G>C upstream_gene_variant 0.54 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.58 rifampicin
rpoB 763077 p.Val1091Thr missense_variant 0.58 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.47 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.34 rifampicin
rpoC 763462 c.93G>C synonymous_variant 0.31 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.56 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763495 c.126G>A synonymous_variant 0.63 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.67 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.66 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.65 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.66 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.66 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763672 c.303C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.51 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.54 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.56 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.55 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.46 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.28 rifampicin
rpoC 763772 p.Val135Met missense_variant 0.24 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.38 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.38 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763966 p.Asp199Glu missense_variant 0.43 rifampicin
rpoC 764405 c.1036_1038delAGGinsCGT synonymous_variant 0.48 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.54 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066A>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764440 c.1071G>T synonymous_variant 0.56 rifampicin
rpoC 764441 p.Ile358Leu missense_variant 0.56 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.54 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.54 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.58 rifampicin
rpoC 764491 c.1122G>C synonymous_variant 0.55 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.38 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.53 rifampicin
rpoC 764512 c.1143G>C synonymous_variant 0.57 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.61 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>G synonymous_variant 0.59 rifampicin
rpoC 764548 c.1179G>C synonymous_variant 0.61 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.66 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.69 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.69 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.63 rifampicin
rpoC 764646 p.Gly426Ala missense_variant 0.52 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764653 c.1284G>C synonymous_variant 0.48 rifampicin
rpoC 764656 c.1287C>G synonymous_variant 0.48 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764705 p.Leu446Ala missense_variant 0.54 rifampicin
rpoC 764734 c.1365C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.46 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781754 c.195G>C synonymous_variant 0.41 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.51 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.53 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>A synonymous_variant 0.64 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.67 streptomycin
rpsL 781796 p.Met79Ile missense_variant 0.66 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.61 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.62 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.6 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.6 streptomycin
rpsL 781856 c.297C>T synonymous_variant 0.42 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>C synonymous_variant 0.45 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.4 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.4 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.4 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.45 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.4 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.2 streptomycin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471991 n.146T>C non_coding_transcript_exon_variant 0.59 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471997 n.152T>C non_coding_transcript_exon_variant 0.59 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471998 n.153G>T non_coding_transcript_exon_variant 0.59 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472005 n.160T>G non_coding_transcript_exon_variant 0.59 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.87 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472425 n.580T>C non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472486 n.641A>G non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472507 n.662C>T non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472508 n.663T>C non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472571 n.726G>A non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472583 n.738T>A non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472673 n.828T>C non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472674 n.829T>A non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472675 n.830T>G non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472682 n.837_842delTTGGGAinsACGTTG non_coding_transcript_exon_variant 0.89 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472793 n.948A>C non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472803 n.958T>C non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.74 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.48 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472970 n.1125delCinsGGCCCTT non_coding_transcript_exon_variant 0.65 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.65 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.73 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472996 n.1151T>C non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473062 n.1217T>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473091 n.1246G>A non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473120 n.1275C>T non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473201 n.1356A>T non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.96 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1473702 n.45G>A non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1473724 n.67T>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1473731 n.74T>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1473735 n.78T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474153 n.496C>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474166 n.509G>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474179 n.522C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474651 n.995delT non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474660 n.1003G>A non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474662 n.1005C>G non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474688 n.1031G>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474690 n.1033C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474802 n.1145T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474896 n.1239A>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475111 n.1454G>A non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475115 n.1458A>G non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475119 n.1462C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475171 n.1514C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475175 n.1518G>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475188 n.1531C>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475508 n.1851A>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475542 n.1885A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.83 capreomycin
linezolid Uncertain significance
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475740 n.2083G>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475788 n.2131C>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475982 n.2325G>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476015 n.2358G>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476126 n.2469C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.98 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476596 n.2939C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476601 n.2944G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833694 c.153G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.48 pyrazinamide
rpsA 1833709 c.168C>G synonymous_variant 0.6 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.66 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.64 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.64 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.61 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.59 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.59 pyrazinamide
rpsA 1833769 c.228C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.44 pyrazinamide
rpsA 1833782 p.Ser81Ala missense_variant 0.44 pyrazinamide
rpsA 1833797 p.Val86Ile missense_variant 0.46 pyrazinamide Uncertain significance
rpsA 1833802 c.261A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.35 pyrazinamide
rpsA 1833815 p.Thr92Gln missense_variant 0.33 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.36 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.39 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.43 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.51 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.6 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.57 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.49 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834255 c.714C>G synonymous_variant 0.61 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.55 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.54 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834307 p.Asp256Gln missense_variant 0.55 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>T synonymous_variant 0.28 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834360 c.819G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834395 p.Arg285Gln missense_variant 0.41 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.43 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.48 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834480 c.939C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834483 p.Glu314Asp missense_variant 0.42 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.32 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 0.95 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
Rv2477c 2783331 p.Glu238Gln missense_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783409 p.Val212Ile missense_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.37 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.17 capreomycin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087704 c.885T>C synonymous_variant 0.15 cycloserine
ald 3087713 c.894G>C synonymous_variant 0.19 cycloserine
ald 3087716 c.897G>C synonymous_variant 0.19 cycloserine
ald 3087727 p.Ala303Gly missense_variant 0.21 cycloserine
ald 3087729 p.Ser304Ala missense_variant 0.21 cycloserine
ald 3087737 c.918G>C synonymous_variant 0.19 cycloserine
ald 3087740 p.Lys307Asn missense_variant 0.19 cycloserine
ald 3087743 c.924G>C synonymous_variant 0.2 cycloserine
ald 3087746 c.927G>C synonymous_variant 0.19 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrA 3627756 c.-407A>T upstream_gene_variant 1.0 rifampicin
bedaquiline
rpoA 3877920 c.588G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877926 p.Leu194Val missense_variant 0.29 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877965 c.543C>G synonymous_variant 0.4 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.42 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.42 rifampicin
clpC1 4038845 c.1860G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038872 c.1833C>G synonymous_variant 0.38 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.36 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039416 p.Glu430Ala missense_variant 0.27 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039481 p.Ala408Ser missense_variant 0.45 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039555 c.1147_1149delGCG conservative_inframe_deletion 0.4 pyrazinamide
clpC1 4039565 c.1139_1140insTCA disruptive_inframe_insertion 0.4 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.44 pyrazinamide Uncertain significance
clpC1 4039575 p.Ala377Glu missense_variant 0.38 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039592 c.1113G>T synonymous_variant 0.42 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.27 pyrazinamide
clpC1 4039823 c.882T>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.42 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.37 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039943 p.Ser254Ala missense_variant 0.36 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.34 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039967 p.Gln246His missense_variant 0.51 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040000 p.His235Lys missense_variant 0.34 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.4 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040054 c.651G>A synonymous_variant 0.31 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.31 pyrazinamide
clpC1 4040066 c.639G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040084 c.621C>T synonymous_variant 0.37 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040117 c.588A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040129 c.576C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.24 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040300 c.405C>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040306 c.399G>C synonymous_variant 0.4 pyrazinamide
clpC1 4040310 p.Thr132Asn missense_variant 0.41 pyrazinamide
clpC1 4040312 c.393G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.4 pyrazinamide
clpC1 4040318 c.387C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040336 c.369G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.26 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.2 pyrazinamide
clpC1 4040648 c.57G>A synonymous_variant 0.19 pyrazinamide
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embA 4245786 p.Ala852Thr missense_variant 1.0 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin