TB-Profiler result

Run: SRR3416776
Summary

Run ID: SRR3416776

Sample name:

Date: 2024-04-14T06:09:45.677017

Number of reads: 3604207

Percentage reads mapped: 71.95

Median coverage: 74.0

Strain: lineage2.1

Spoligotype:

Drug-resistance: Other

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.99
La1.2.BCG M.bovis None 0.08
lineage2.1 East-Asian (non-Beijing) None 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.32 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247448 p.His312Arg missense_variant 0.17 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 852 c.852G>A synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 1220 p.Asn407Ser missense_variant 0.17 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.23 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.23 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.24 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.23 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.21 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.22 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.16 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.17 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.15 isoniazid
gyrB 6123 p.Ala295Gly missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.16 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7514 c.213C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8121 c.820T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8186 c.885G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8285 p.Ile328Met missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8420 c.1119T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8837 c.1536C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.2 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9154 p.Thr618Asn missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
fgd1 490797 c.15G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575695 c.348C>A synonymous_variant 0.15 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.2 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.23 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.22 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.16 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.16 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.17 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.26 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.25 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
mshA 575864 c.517T>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.26 ethionamide
isoniazid
ccsA 619591 c.-300G>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619594 c.-297G>T upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>T synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.16 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.15 ethionamide
Rv0565c 657690 c.-220C>A upstream_gene_variant 0.15 ethionamide
hadA 731774 c.-156T>C upstream_gene_variant 0.2 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.18 isoniazid
hadA 731791 c.-139_-138delAGinsGA upstream_gene_variant 0.81 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.2 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.2 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.17 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.17 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.18 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.19 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.19 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.21 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.29 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.34 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.32 isoniazid
nusG 734451 c.198G>C synonymous_variant 0.17 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.16 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.15 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.15 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.18 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.21 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.21 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.19 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.2 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.2 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.17 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.18 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.17 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.22 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.17 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.17 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.19 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.19 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.25 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.23 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.27 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.25 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.21 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.16 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.2 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.19 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.16 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.2 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.19 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.22 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.21 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.2 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.21 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.2 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.18 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.22 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.27 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.25 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.24 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.28 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.27 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.26 rifampicin
rpoB 761373 p.Val523His missense_variant 0.22 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.22 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761477 c.1671C>G synonymous_variant 0.21 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.22 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.24 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.29 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.35 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.33 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.27 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.15 rifampicin
rpoB 761773 p.His656Pro missense_variant 0.16 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.17 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.18 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.19 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.19 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.17 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.16 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.18 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.33 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.26 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.23 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.23 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.24 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.28 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.31 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.29 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.28 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.3 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.18 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.18 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.23 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.25 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.22 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.22 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.22 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.17 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.18 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.18 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.23 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.26 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.76 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.26 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.22 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.21 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.19 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.15 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.18 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.24 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.33 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.23 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.27 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.34 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.34 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.34 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.33 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.34 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.35 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.21 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.2 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.2 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.18 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.15 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.15 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.15 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763915 c.546C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.16 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.18 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.19 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.16 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.16 rifampicin
rpoC 764215 c.846A>G synonymous_variant 0.21 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.2 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.18 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.19 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.21 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.24 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.18 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.18 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.15 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.21 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765319 c.1950A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.23 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.23 rifampicin Uncertain significance
rpoC 765346 c.1977C>G synonymous_variant 0.23 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.24 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.26 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.23 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>A synonymous_variant 0.21 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.28 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.29 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.3 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.3 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.35 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.35 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.33 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.28 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.25 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.25 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.25 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.24 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.24 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.23 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.2 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.32 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.31 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.29 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.28 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.29 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.23 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.25 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.26 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.26 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.18 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.15 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.16 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.17 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.22 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.21 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.22 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.24 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.22 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.23 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.26 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.32 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.35 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.32 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.35 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.38 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.37 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.35 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.4 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.32 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.22 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.21 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.2 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.21 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.24 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.21 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.29 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.26 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.26 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.32 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.31 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.37 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.36 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.29 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.32 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.33 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.37 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.26 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.26 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.28 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.35 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.26 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.19 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.23 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775981 p.Leu834Met missense_variant 0.14 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777170 c.1311T>C synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.16 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.18 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.17 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.18 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.26 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.29 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.29 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.22 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.23 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.24 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.22 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.2 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.18 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.19 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.19 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.19 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.21 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.22 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.24 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.22 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.2 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.21 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.18 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.18 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.21 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.23 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.23 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.2 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.21 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.16 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.15 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.21 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.22 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.25 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.25 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.26 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.28 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.24 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.19 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.19 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.19 linezolid
rplC 800814 c.6A>G synonymous_variant 0.17 linezolid
rplC 800817 c.9A>T synonymous_variant 0.16 linezolid
rplC 801207 c.399C>T synonymous_variant 0.16 linezolid
rplC 801300 c.492C>G synonymous_variant 0.21 linezolid
rplC 801309 c.501C>G synonymous_variant 0.2 linezolid
rplC 801312 c.504G>C synonymous_variant 0.22 linezolid
rplC 801321 c.513C>T synonymous_variant 0.2 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.21 linezolid
rplC 801339 c.531T>C synonymous_variant 0.2 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.2 linezolid
rplC 801348 c.540T>G synonymous_variant 0.24 linezolid
rplC 801357 c.549T>C synonymous_variant 0.26 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.3 linezolid
rplC 801402 c.594T>C synonymous_variant 0.2 linezolid
rplC 801405 c.597T>C synonymous_variant 0.21 linezolid
rplC 801423 c.615G>C synonymous_variant 0.19 linezolid
rplC 801426 c.618C>G synonymous_variant 0.18 linezolid
rplC 801427 p.Met207Val missense_variant 0.19 linezolid
rplC 801438 c.630T>C synonymous_variant 0.25 linezolid
rplC 801442 p.Ile212Val missense_variant 0.26 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304132 p.Ala401Gly missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304187 c.1257T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304208 c.1278C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304443 p.Ala505Thr missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1304553 c.1623C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
sigE 1364898 c.486C>T synonymous_variant 0.2 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.21 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.18 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.15 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.16 pyrazinamide
sigE 1365036 c.624T>C synonymous_variant 0.19 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.21 pyrazinamide
sigE 1365063 c.651A>C synonymous_variant 0.21 pyrazinamide
sigE 1365084 c.672G>C synonymous_variant 0.17 pyrazinamide
sigE 1365090 c.678T>C synonymous_variant 0.16 pyrazinamide
sigE 1365096 c.684G>C synonymous_variant 0.16 pyrazinamide
sigE 1365099 c.687A>C synonymous_variant 0.17 pyrazinamide
atpE 1460831 c.-214T>C upstream_gene_variant 0.16 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.16 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.17 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.21 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.24 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.23 bedaquiline
atpE 1460897 c.-148A>C upstream_gene_variant 0.23 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.21 bedaquiline
atpE 1460915 c.-130C>G upstream_gene_variant 0.17 bedaquiline
atpE 1460918 c.-127A>G upstream_gene_variant 0.17 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.15 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.16 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
fabG1 1673633 p.Ser65Asn missense_variant 0.14 ethionamide
isoniazid
fabG1 1673641 p.Val68Ile missense_variant 0.18 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.18 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.19 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.19 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.24 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.28 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.24 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.19 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.16 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.14 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.26 ethionamide
isoniazid
inhA 1674855 c.654C>G synonymous_variant 0.26 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674864 c.663C>T synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.25 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.27 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.22 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.3 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.35 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.25 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834510 c.969C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.29 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.19 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.25 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.24 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.23 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917940 p.Val1Met missense_variant 0.15 capreomycin
tlyA 1917943 p.Ala2Ser missense_variant 0.15 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.18 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.19 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.23 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.23 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>G synonymous_variant 0.24 capreomycin
tlyA 1918002 c.63A>G synonymous_variant 0.23 capreomycin
bacA 2064972 c.-244T>C upstream_gene_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101920 c.1123A>C synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2101924 c.1119T>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>G synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101963 c.1080G>A synonymous_variant 0.19 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Asp missense_variant 0.14 ethionamide
delamanid
isoniazid
ndh 2102218 c.825C>A synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102227 c.816C>T synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102230 c.813G>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.23 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102680 c.363T>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102686 c.357G>C synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102695 c.348C>T synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102700 c.343C>T synonymous_variant 0.15 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155661 p.Val151Ile missense_variant 0.15 isoniazid
katG 2155677 c.435C>G synonymous_variant 0.26 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.29 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.28 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.28 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.28 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.23 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.23 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.19 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289987 c.-746C>T upstream_gene_variant 0.25 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.2 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.21 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.2 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.22 pyrazinamide
pncA 2290015 c.-774A>C upstream_gene_variant 0.19 pyrazinamide
pncA 2290024 c.-783C>G upstream_gene_variant 0.17 pyrazinamide
pncA 2290030 c.-791_-789delAATinsCC upstream_gene_variant 0.19 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.25 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.18 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.18 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.17 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.23 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.29 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.28 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.3 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.25 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.22 isoniazid
kasA 2518261 p.Glu49Asp missense_variant 0.16 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.16 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.17 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.16 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.18 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.18 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.17 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.17 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.16 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.24 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.25 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.22 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.19 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.18 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.19 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.2 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.18 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.18 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.18 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.18 isoniazid
kasA 2519056 c.942G>C synonymous_variant 0.18 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.26 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.24 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.24 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.33 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.32 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.38 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.32 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.3 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.3 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.3 isoniazid
kasA 2519196 p.Thr361Ser missense_variant 0.17 isoniazid
ahpC 2726336 c.144G>C synonymous_variant 0.17 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.2 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ahpC 2726645 c.453C>G synonymous_variant 0.15 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.18 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.17 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ahpC 2726687 c.495C>G synonymous_variant 0.21 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.2 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.18 isoniazid
folC 2747086 c.513A>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747248 c.351G>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747264 p.Gly112Ala missense_variant 0.29 para-aminosalicylic_acid
folC 2747266 c.333C>T synonymous_variant 0.29 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.31 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.3 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.31 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.38 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.28 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.24 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.23 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747407 c.192T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747772 c.-174C>G upstream_gene_variant 0.17 para-aminosalicylic_acid
folC 2747790 c.-192G>C upstream_gene_variant 0.16 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.21 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783650 c.393C>T synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783656 c.387G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783790 p.Val85Ile missense_variant 0.86 ethambutol Not assoc w R
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783797 p.Asp82Glu missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784435 c.-393C>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784441 c.-399G>A upstream_gene_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784452 c.-410C>T upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784454 c.-412G>A upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3066066 c.126T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067349 c.597G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067442 c.504C>T synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.25 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067510 c.436C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.21 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.17 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.23 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.22 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.23 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.24 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.23 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.17 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.18 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.22 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067775 c.171C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.36 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067877 c.69G>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.28 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074244 c.228A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074263 p.Gly70Ala missense_variant 0.15 para-aminosalicylic_acid
thyA 3074423 p.Pro17Ala missense_variant 0.15 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624077 c.834G>A synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624107 c.804C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624143 c.768T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624404 c.507G>T synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624407 c.504C>T synonymous_variant 0.18 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624410 c.501C>T synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624416 c.495G>A synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ala missense_variant 0.18 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624437 c.474G>A synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624461 c.450C>G synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625569 c.1045T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.22 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625669 c.-759G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.23 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.26 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625843 c.-933C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.16 bedaquiline
rifampicin
mtrA 3626792 c.558G>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626945 c.-332C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627167 c.-554T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.24 bedaquiline
rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.27 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.34 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.43 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.33 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.36 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.29 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.25 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.31 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.32 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.31 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.29 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.29 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.29 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.25 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.26 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.27 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.17 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.26 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.31 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.41 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.35 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.31 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.28 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.27 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.26 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.26 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.26 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.26 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.27 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.29 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.26 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.27 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.23 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.21 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.17 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.16 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.17 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.18 rifampicin
rpoA 3878683 c.-176G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.33 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.28 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.28 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.27 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.33 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.33 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.32 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.33 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.3 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.36 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.32 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.27 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.23 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.19 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.31 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.31 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.33 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.29 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.21 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.15 delamanid
pretomanid
clpC1 4038392 c.2313C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.14 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.16 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.15 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.16 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.24 pyrazinamide
clpC1 4038541 c.2164C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.21 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.19 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.17 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038749 c.1956C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.34 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.38 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.41 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.39 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.24 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.14 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039481 c.1224T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039577 c.1128T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.36 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.21 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.22 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.3 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.15 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.19 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.2 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.2 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.23 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.22 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.19 pyrazinamide
panD 4044926 c.-645C>A upstream_gene_variant 0.16 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.16 pyrazinamide
panD 4044935 c.-655_-654delAAinsTG upstream_gene_variant 0.17 pyrazinamide
panD 4044941 c.-660G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.26 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.37 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.4 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.41 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.4 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.4 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.36 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.36 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.38 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.4 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.35 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.27 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.27 pyrazinamide
glpK 4138681 p.Met359Val missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139137 p.Asp207Asn missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139143 c.613T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139195 c.561G>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139198 c.558C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139207 c.549T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139231 c.525A>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139588 c.168G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4239336 c.-527T>C upstream_gene_variant 0.16 ethambutol
embC 4239341 c.-522G>C upstream_gene_variant 0.16 ethambutol
embC 4239344 c.-519G>C upstream_gene_variant 0.16 ethambutol
embC 4239378 c.-485T>A upstream_gene_variant 0.16 ethambutol
embC 4239383 c.-480C>G upstream_gene_variant 0.17 ethambutol
embC 4239386 c.-477G>A upstream_gene_variant 0.18 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.25 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.25 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.25 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.2 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.16 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.3 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.27 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.28 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.24 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.17 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.19 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.18 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.17 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.17 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.18 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241479 c.1617C>G synonymous_variant 0.18 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.18 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.17 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
embA 4242742 c.-491C>G upstream_gene_variant 0.16 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.16 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.16 ethambutol
embA 4242772 c.-461G>C upstream_gene_variant 0.19 ethambutol
embA 4242892 c.-341G>C upstream_gene_variant 0.16 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.19 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.2 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.22 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.34 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.33 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.34 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.34 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.37 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.37 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.35 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.3 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.27 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.19 ethambutol
embA 4245693 p.Ile821Val missense_variant 0.17 ethambutol
embB 4245701 c.-813G>C upstream_gene_variant 0.19 ethambutol
embB 4245704 c.-810G>C upstream_gene_variant 0.2 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.24 ethambutol
embB 4245726 c.-788T>C upstream_gene_variant 0.25 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.23 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.22 ethambutol
embB 4245851 c.-663G>C upstream_gene_variant 0.17 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.16 ethambutol
embA 4246088 c.2856A>G synonymous_variant 1.0 ethambutol Not assoc w R
embB 4246205 c.-309A>G upstream_gene_variant 0.16 ethambutol
embB 4246217 c.-297G>A upstream_gene_variant 0.19 ethambutol
embB 4246223 c.-291C>T upstream_gene_variant 0.16 ethambutol
embA 4246227 p.Ile999Val missense_variant 0.16 ethambutol
embA 4246235 c.3003G>A synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embA 4246242 p.Gln1004Gly missense_variant 0.21 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.22 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.22 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.22 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.19 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.2 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.2 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.2 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.21 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.2 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.22 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.19 ethambutol
embA 4246359 c.3127_3129delGCCinsTG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
embB 4246367 c.-147C>T upstream_gene_variant 0.17 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.15 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.16 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.17 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.17 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.21 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.21 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.22 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.21 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.18 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.16 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.16 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.17 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.17 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.16 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.17 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.18 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.18 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247940 p.Leu476Trp missense_variant 0.23 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.24 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.21 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.19 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.18 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.16 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.16 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.18 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.16 ethambutol Uncertain significance
embB 4248070 c.1557T>C synonymous_variant 0.2 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.19 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.23 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.27 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.27 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.27 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.31 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.21 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.21 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.21 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.22 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.25 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.26 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.24 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.24 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.2 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.18 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.15 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.16 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.16 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.2 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.25 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.16 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.88 ethambutol Not assoc w R
aftB 4268994 c.-158T>G upstream_gene_variant 0.17 ethambutol
ubiA 4268999 c.835C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
aftB 4269006 c.-170T>C upstream_gene_variant 0.19 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.22 ethambutol
ubiA 4269027 c.807C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
aftB 4269033 c.-197T>C upstream_gene_variant 0.23 ethambutol
aftB 4269036 c.-200C>G upstream_gene_variant 0.22 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.22 ethambutol
ubiA 4269102 c.732C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.98 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R