TB-Profiler result

Run: ERR405209
Summary

Run ID: ERR405209

Sample name:

Date: 2024-10-05T11:15:35.129399

Number of reads: 122070

Percentage reads mapped: 2.32

Median coverage: 1.0

Strain: La1.7;lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.7 M.bovis None 0.05
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6115 c.876A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6148 c.909C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrB 6160 c.921C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrB 6196 c.957C>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6204 p.Ser322Thr missense_variant 1.0 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7569 p.Ala90Ser missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7601 c.300C>G synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 7637 c.336C>A synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 7661 c.360C>G synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 7667 c.366C>T synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
ccsA 620631 c.741T>C synonymous_variant 0.9 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.83 kanamycin
capreomycin
amikacin
ccsA 620652 c.762C>G synonymous_variant 0.92 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>T synonymous_variant 0.92 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620688 c.798G>T synonymous_variant 1.0 kanamycin
capreomycin
amikacin
ccsA 620694 c.804C>G synonymous_variant 1.0 kanamycin
capreomycin
amikacin
ccsA 620698 p.Val270Ile missense_variant 1.0 kanamycin
capreomycin
amikacin
Rv0565c 657644 c.-174G>C upstream_gene_variant 0.9 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.92 ethionamide
Rv0565c 657670 c.-200A>G upstream_gene_variant 0.85 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.85 ethionamide
Rv0565c 657677 c.-209_-207delAACinsGGT upstream_gene_variant 0.85 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.85 ethionamide
Rv0565c 657703 c.-233C>A upstream_gene_variant 0.92 ethionamide
nusG 734472 c.219T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 1.0 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.94 rifampicin
nusG 734532 c.279A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 1.0 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.9 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760181 c.375T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 1.0 rifampicin
rpoB 760235 c.429T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 1.0 rifampicin
rpoB 760316 c.510C>G synonymous_variant 1.0 rifampicin
rpoB 760328 c.522G>C synonymous_variant 1.0 rifampicin
rpoB 760331 c.525G>C synonymous_variant 1.0 rifampicin
rpoB 760337 c.531C>G synonymous_variant 1.0 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760346 c.540C>T synonymous_variant 1.0 rifampicin
rpoB 760356 p.Thr184Ser missense_variant 1.0 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 1.0 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 1.0 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 1.0 rifampicin
rpoB 760484 c.678A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 1.0 rifampicin
rpoB 760508 c.702G>C synonymous_variant 1.0 rifampicin
rpoB 760511 c.705G>C synonymous_variant 1.0 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 1.0 rifampicin Uncertain significance
rpoB 760625 c.819C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.88 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 1.0 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 1.0 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 1.0 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 1.0 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 1.0 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 1.0 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.7 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.82 rifampicin
rpoB 762251 c.2445G>C synonymous_variant 0.82 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.8 rifampicin
rpoB 762491 c.2685T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 1.0 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 1.0 rifampicin Uncertain significance
rpoB 762879 p.Met1025Leu missense_variant 1.0 rifampicin Uncertain significance
rpoC 762884 c.-486G>A upstream_gene_variant 0.71 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762925 p.Thr1040Ile missense_variant 0.52 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762939 p.Met1045Leu missense_variant 0.52 rifampicin
rpoB 762942 p.Ile1046Val missense_variant 0.52 rifampicin Uncertain significance
rpoB 762962 c.3156C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762980 c.-390T>C upstream_gene_variant 0.44 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.85 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.46 rifampicin
rpoC 762998 c.-372G>A upstream_gene_variant 0.3 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.82 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.8 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 1.0 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.93 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.9 rifampicin
rpoC 763217 c.-153G>C upstream_gene_variant 0.82 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.9 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.9 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.9 rifampicin
rpoB 763241 p.Glu1145Asp missense_variant 0.91 rifampicin
rpoC 763259 c.-111G>T upstream_gene_variant 0.9 rifampicin
rpoB 763265 c.3459G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.92 rifampicin
rpoC 763456 c.87A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763501 c.132C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>T synonymous_variant 0.89 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.95 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.95 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 1.0 rifampicin
rpoC 763714 c.345G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 1.0 rifampicin
rpoC 763741 c.372C>T synonymous_variant 1.0 rifampicin
rpoC 763744 c.375G>C synonymous_variant 1.0 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.9 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764296 c.927G>C synonymous_variant 0.9 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.94 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764429 c.1060C>T synonymous_variant 0.93 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.92 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.93 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.93 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 1.0 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.95 rifampicin
rpoC 764491 c.1122G>C synonymous_variant 0.95 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.94 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764551 c.1182G>C synonymous_variant 0.92 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764671 c.1302G>T synonymous_variant 0.96 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764800 c.1431G>A synonymous_variant 0.9 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.95 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.85 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764857 c.1488G>T synonymous_variant 0.85 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.93 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.91 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 1.0 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 1.0 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765419 p.Val684Ile missense_variant 0.92 rifampicin Uncertain significance
rpoC 765425 p.Lys686Glu missense_variant 0.93 rifampicin
rpoC 765452 p.Ala695Arg missense_variant 0.94 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.95 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.87 rifampicin Uncertain significance
rpoC 765493 c.2124G>C synonymous_variant 0.88 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.88 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.88 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>A synonymous_variant 0.82 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.82 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766348 c.2979A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.89 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.89 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.89 rifampicin
rpoC 766423 c.3054T>C synonymous_variant 0.9 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.9 rifampicin
rpoC 766429 c.3060C>G synonymous_variant 0.9 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.88 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.89 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.93 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.93 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.92 rifampicin
rpoC 766493 p.Gly1042Asn missense_variant 0.91 rifampicin
rpoC 766517 p.Thr1050Ser missense_variant 1.0 rifampicin
rpoC 766525 c.3156G>T synonymous_variant 1.0 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 1.0 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 1.0 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 1.0 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.95 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.95 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.95 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 766579 c.3210C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.95 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.89 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.94 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.94 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.93 rifampicin
rpoC 766634 p.Phe1089Ile missense_variant 0.92 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 1.0 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 1.0 rifampicin
rpoC 766732 c.3363G>C synonymous_variant 1.0 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.94 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.94 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.94 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.95 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.95 rifampicin
rpoC 766776 p.Arg1136His missense_variant 0.95 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.93 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 1.0 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 1.0 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
mmpL5 775916 c.2565T>C synonymous_variant 0.9 bedaquiline
clofazimine
mmpL5 776024 c.2457G>C synonymous_variant 1.0 bedaquiline
clofazimine
mmpL5 776030 c.2451G>C synonymous_variant 1.0 bedaquiline
clofazimine
rpsL 781628 c.69T>C synonymous_variant 0.91 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.92 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.85 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.93 streptomycin
rpsL 781676 c.117C>G synonymous_variant 0.87 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.93 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.94 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.94 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.85 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.94 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.89 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.94 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.89 streptomycin
rpsL 781754 c.195G>A synonymous_variant 0.94 streptomycin Not assoc w R - Interim
rpsL 781760 c.201T>C synonymous_variant 0.95 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.96 streptomycin Not assoc w R - Interim
rpsL 781811 c.252C>T synonymous_variant 0.93 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.97 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.96 streptomycin
rpsL 781829 c.270G>C synonymous_variant 1.0 streptomycin
rpsL 781832 c.273T>C synonymous_variant 1.0 streptomycin
rpsL 781841 c.282C>T synonymous_variant 1.0 streptomycin
rpsL 781865 c.306G>C synonymous_variant 1.0 streptomycin
rpsL 781868 c.309T>C synonymous_variant 1.0 streptomycin
rpsL 781871 c.312G>C synonymous_variant 1.0 streptomycin
rplC 800654 c.-155T>C upstream_gene_variant 0.93 linezolid
rplC 800672 c.-137G>T upstream_gene_variant 0.94 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 1.0 linezolid
rplC 800693 c.-116A>T upstream_gene_variant 1.0 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 1.0 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 1.0 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.85 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.83 linezolid
fbiC 1304559 p.Glu543Asp missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>G synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.92 pretomanid
delamanid
clofazimine
rrs 1471922 n.78delT non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.92 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>T non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472240 n.395G>C non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472242 n.397C>T non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472333 n.488G>T non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.74 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472349 n.504A>C non_coding_transcript_exon_variant 0.73 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472350 n.505C>T non_coding_transcript_exon_variant 0.7 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472373 n.528G>A non_coding_transcript_exon_variant 0.7 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472374 n.529T>G non_coding_transcript_exon_variant 0.73 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472390 n.545T>A non_coding_transcript_exon_variant 0.7 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472391 n.546C>T non_coding_transcript_exon_variant 0.71 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472412 n.567A>C non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472415 n.570T>G non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>T non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472715 n.870C>G non_coding_transcript_exon_variant 0.49 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472716 n.871C>A non_coding_transcript_exon_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472754 n.909G>T non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472812 n.967A>C non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472847 n.1002G>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>A non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472887 n.1042G>C non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472936 n.1091C>T non_coding_transcript_exon_variant 0.73 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472959 n.1114T>A non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472963 n.1118G>A non_coding_transcript_exon_variant 0.67 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472982 n.1137G>C non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.58 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473002 n.1157G>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473008 n.1163C>A non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473009 n.1164T>C non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473044 n.1199C>G non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473051 n.1206T>C non_coding_transcript_exon_variant 0.58 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473053 n.1208T>G non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473097 n.1252G>C non_coding_transcript_exon_variant 0.57 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473147 n.1302G>C non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>G non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473193 n.1348G>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin
streptomycin
amikacin Uncertain significance
rrs 1473198 n.1354delC non_coding_transcript_exon_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473204 n.1359C>T non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526_528delTCGinsCCA non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474284 n.629dupC non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474291 n.635_642delTTCCTCTC non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474301 n.644G>A non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474302 n.645G>C non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1475517 n.1860C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475518 n.1861A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475540 n.1883C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475551 n.1894T>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475555 n.1898T>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475564 n.1907C>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475574 n.1917C>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475576 n.1919C>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475791 n.2134A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476266 n.2609G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476279 n.2622G>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476339 n.2682G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476356 n.2699C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476384 n.2727G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476501 n.2844C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
inhA 1674522 c.321G>A synonymous_variant 0.93 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674531 c.330C>T synonymous_variant 0.94 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.94 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.94 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.93 isoniazid
ethionamide
inhA 1674550 p.Ser117Ala missense_variant 0.93 isoniazid
ethionamide
inhA 1674573 c.372G>C synonymous_variant 0.83 isoniazid
ethionamide
inhA 1674729 c.528G>C synonymous_variant 0.8 isoniazid
ethionamide
inhA 1674732 c.531C>T synonymous_variant 0.8 isoniazid
ethionamide
inhA 1674742 p.Lys181Pro missense_variant 0.8 isoniazid
ethionamide
inhA 1674750 c.549T>G synonymous_variant 0.8 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.82 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.82 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674777 c.576C>A synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.8 isoniazid
ethionamide
inhA 1674795 c.594G>C synonymous_variant 0.85 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.83 isoniazid
ethionamide
inhA 1674804 c.603G>C synonymous_variant 0.83 isoniazid
ethionamide Not assoc w R - Interim
rpsA 1833664 c.123C>G synonymous_variant 0.91 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.83 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.83 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.91 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.91 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 1.0 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.87 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.95 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.94 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.94 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.94 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.93 pyrazinamide
rpsA 1833859 c.318C>G synonymous_variant 0.93 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.93 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.93 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.77 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 1.0 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.81 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.95 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.96 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.94 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.94 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.97 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.96 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.96 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.92 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.95 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.95 pyrazinamide
rpsA 1834066 c.525G>A synonymous_variant 0.92 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.92 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.85 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.92 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.91 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.83 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
rpsA 1834234 c.693G>C synonymous_variant 0.8 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.9 pyrazinamide
rpsA 1834282 c.741C>T synonymous_variant 0.95 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.89 pyrazinamide
rpsA 1834298 p.Gln253Thr missense_variant 0.94 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.94 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.81 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 1.0 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 1.0 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.92 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 1.0 pyrazinamide
rpsA 1834678 c.1137C>T synonymous_variant 0.94 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.91 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 1.0 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.9 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.9 linezolid
kasA 2517941 c.-174C>G upstream_gene_variant 0.9 isoniazid
lpqB 3625285 c.-375G>C upstream_gene_variant 0.9 rifampicin
bedaquiline
mtrB 3625321 c.1293A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625792 c.-882G>C upstream_gene_variant 0.92 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625837 c.-927C>T upstream_gene_variant 1.0 rifampicin
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 1.0 rifampicin
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrB 3625867 c.747A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>A upstream_gene_variant 0.9 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626825 c.525T>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626849 c.-236C>T upstream_gene_variant 1.0 rifampicin
bedaquiline
rpoA 3877638 c.870T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.93 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.92 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.92 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.9 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.92 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.83 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.9 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.9 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.9 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>C synonymous_variant 1.0 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 1.0 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 1.0 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 1.0 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.91 rifampicin Uncertain significance
rpoA 3879088 c.-581A>C upstream_gene_variant 1.0 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 1.0 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 1.0 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.91 rifampicin
clpC1 4038350 c.2355C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>T synonymous_variant 0.94 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038842 c.1863G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 1.0 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.95 pyrazinamide
clpC1 4039009 c.1696C>T synonymous_variant 0.95 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.9 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039128 p.Lys526Arg missense_variant 0.96 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.96 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.95 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.89 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.95 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.86 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.96 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.82 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039280 c.1425G>T synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>G synonymous_variant 0.83 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.85 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.86 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.95 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.94 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.94 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>T synonymous_variant 0.92 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039574 p.Ala377Ser missense_variant 1.0 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039616 c.1089G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039622 c.1083C>A synonymous_variant 0.95 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039688 c.1017G>A synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
clpC1 4039694 c.1011G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039700 c.1005C>T synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
clpC1 4039724 c.981A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.92 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.88 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.88 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.87 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.87 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.87 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.88 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.92 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 1.0 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>T synonymous_variant 1.0 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
embC 4240756 c.894G>C synonymous_variant 0.9 ethambutol
embC 4240768 c.906G>T synonymous_variant 0.91 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.91 ethambutol
embC 4240777 c.915G>A synonymous_variant 0.91 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.83 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.83 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.86 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.91 ethambutol