TB-Profiler result

Run: SRR9971270
Summary

Run ID: SRR9971270

Sample name:

Date: 2024-10-04T22:28:46.669608

Number of reads: 2746712

Percentage reads mapped: 56.42

Median coverage: 70.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Leu430Pro Assoc w R
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761095 p.Leu430Pro missense_variant 1.0 rifampicin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 624 c.624C>T synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 630 c.630C>G synonymous_variant 0.29 isoniazid
dnaA 633 c.633T>A synonymous_variant 0.29 isoniazid
dnaA 645 c.645A>G synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>C synonymous_variant 0.34 isoniazid Not assoc w R - Interim
dnaA 660 c.660G>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.3 isoniazid
dnaA 667 p.Asn223His missense_variant 0.32 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 682 c.682T>C synonymous_variant 0.31 isoniazid
dnaA 699 c.699G>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.26 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.27 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.23 isoniazid
dnaA 753 c.753C>T synonymous_variant 0.21 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.13 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.14 isoniazid
dnaA 781 p.Ser261Arg missense_variant 0.13 isoniazid
gyrA 6712 c.-590G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 p.Ala504Ser missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6764 p.Leu509Phe missense_variant 0.2 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6784 c.-518C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6798 p.Gly520Ala missense_variant 0.21 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6811 c.1572C>T synonymous_variant 0.22 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8982 p.Cys561Ser missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575907 p.Ala187Val missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 656467 p.Gly335Glu missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734505 c.252G>C synonymous_variant 0.13 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734543 p.Arg97Gln missense_variant 0.21 rifampicin
nusG 734548 p.Gln99Lys missense_variant 0.2 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.2 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760088 c.282C>G synonymous_variant 0.12 rifampicin
rpoB 760106 c.300G>C synonymous_variant 0.12 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760139 c.333A>C synonymous_variant 0.24 rifampicin
rpoB 760140 p.Pro112Ser missense_variant 0.24 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.25 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.29 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.28 rifampicin
rpoB 760184 c.378A>C synonymous_variant 0.3 rifampicin
rpoB 760199 c.393C>G synonymous_variant 0.31 rifampicin
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.2 rifampicin
rpoB 760241 c.435G>C synonymous_variant 0.21 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760265 p.Met153Ile missense_variant 0.21 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.19 rifampicin Uncertain significance
rpoB 760282 p.Thr159Ser missense_variant 0.14 rifampicin
rpoB 761192 c.1386C>G synonymous_variant 0.17 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.21 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761240 c.1434C>T synonymous_variant 0.2 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>A synonymous_variant 0.25 rifampicin
rpoB 761288 c.1482G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.15 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.14 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.13 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762020 c.2214G>A synonymous_variant 0.14 rifampicin
rpoB 762026 c.2220G>A synonymous_variant 0.15 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.16 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>G synonymous_variant 0.18 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.25 rifampicin
rpoB 762128 c.2322G>C synonymous_variant 0.27 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.29 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.3 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762161 c.2355C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.34 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>A synonymous_variant 0.34 rifampicin
rpoB 762218 c.2412T>C synonymous_variant 0.31 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.28 rifampicin
rpoB 762245 c.2439G>T synonymous_variant 0.23 rifampicin
rpoB 762251 c.2445G>C synonymous_variant 0.21 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.21 rifampicin
rpoB 762275 c.2469C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.17 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.13 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762858 p.Thr1018Ser missense_variant 0.15 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762881 p.Met1025Ile missense_variant 0.19 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762917 c.-453C>T upstream_gene_variant 0.23 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.23 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763022 c.-348C>G upstream_gene_variant 0.22 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.77 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.3 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.26 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.29 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>C upstream_gene_variant 0.17 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.15 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763619 p.Arg84Lys missense_variant 0.21 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>A synonymous_variant 0.18 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.17 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.18 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.19 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.21 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.2 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.2 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.21 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.2 rifampicin
rpoC 763768 c.399C>A synonymous_variant 0.19 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.17 rifampicin
rpoC 764143 c.774G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.13 rifampicin Uncertain significance
rpoC 764153 p.Gln262Lys missense_variant 0.14 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.14 rifampicin
rpoC 764162 p.Ile265Leu missense_variant 0.13 rifampicin
rpoC 764169 p.Asn267Thr missense_variant 0.14 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764206 p.Asp279Glu missense_variant 0.15 rifampicin
rpoC 764221 c.852C>T synonymous_variant 0.18 rifampicin
rpoC 764227 c.858G>C synonymous_variant 0.19 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.2 rifampicin
rpoC 764254 c.885G>A synonymous_variant 0.22 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.22 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.21 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.21 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.26 rifampicin
rpoC 764308 c.939G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764320 c.951C>G synonymous_variant 0.26 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.23 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.16 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764437 c.1068G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.16 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.26 rifampicin
rpoC 764503 c.1134G>T synonymous_variant 0.23 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.35 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>T synonymous_variant 0.35 rifampicin
rpoC 764602 c.1233C>G synonymous_variant 0.37 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.35 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764686 c.1317C>T synonymous_variant 0.36 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.29 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.29 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.27 rifampicin
rpoC 764756 c.1387_1389delCTCinsTTG synonymous_variant 0.27 rifampicin
rpoC 764764 p.His465Gln missense_variant 0.29 rifampicin
rpoC 764782 c.1413C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764785 c.1416C>A synonymous_variant 0.28 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.27 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764812 p.Gln482Ala missense_variant 0.19 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764854 c.1485G>C synonymous_variant 0.24 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>T synonymous_variant 0.15 rifampicin
rpoC 764875 c.1506C>G synonymous_variant 0.15 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.15 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.14 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.14 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764980 c.1611C>T synonymous_variant 0.23 rifampicin
rpoC 765004 c.1635G>T synonymous_variant 0.22 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765013 c.1644C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.22 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>G synonymous_variant 0.21 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.17 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.16 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.19 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.17 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.18 rifampicin
rpoC 766361 p.Val998Ile missense_variant 0.18 rifampicin
rpoC 766369 c.3000C>A synonymous_variant 0.19 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.19 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.2 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.2 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.19 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.17 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766411 c.3042C>G synonymous_variant 0.2 rifampicin
rpoC 766435 p.Glu1022Asp missense_variant 0.16 rifampicin Uncertain significance
rpoC 766456 c.3087C>G synonymous_variant 0.15 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.14 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.14 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>C synonymous_variant 0.19 rifampicin
rpoC 767017 c.3648C>G synonymous_variant 0.22 rifampicin
rpoC 767023 p.Asp1218Glu missense_variant 0.23 rifampicin
rpoC 767026 c.3657G>C synonymous_variant 0.24 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.26 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.26 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767087 p.Cys1240Ser missense_variant 0.26 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.22 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781781 c.222G>C synonymous_variant 0.22 streptomycin
rpsL 781802 c.243G>T synonymous_variant 0.23 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.16 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.12 streptomycin
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471981 n.136C>G non_coding_transcript_exon_variant 0.12 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472068 n.223T>G non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472288 n.443A>T non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.4 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.35 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472326 n.481T>A non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601dupT non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472449 n.604_607delCACGinsGCA non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>A non_coding_transcript_exon_variant 0.36 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>A non_coding_transcript_exon_variant 0.51 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.58 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.58 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472846 n.1001_1002insA non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472849 n.1005delT non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472960 n.1115G>A non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472986 n.1141C>T non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.16 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>G non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473811 n.154C>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473812 n.155G>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_172insCT non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473835 n.179delA non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474627 n.970G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979_982delACCGinsTTAC non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474721 n.1064G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474722 n.1065T>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475059 n.1404_1405delCA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475064 n.1407G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475067 n.1410_1411insG non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475080 n.1423G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475081 n.1424C>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101delAinsGTT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475762 n.2106_2108delCAA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.36 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833734 p.Ala65Ser missense_variant 0.24 pyrazinamide
rpsA 1833739 c.198C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833770 p.Asn77Ser missense_variant 0.21 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833782 p.Ser81Asn missense_variant 0.22 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833808 c.267G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.25 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.27 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.33 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.31 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.28 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.3 pyrazinamide
rpsA 1834018 c.477C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.3 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
rpsA 1834210 c.669C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834299 p.Gln253Pro missense_variant 0.12 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.16 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>T synonymous_variant 0.17 pyrazinamide
rpsA 1834357 c.816T>G synonymous_variant 0.19 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.25 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.24 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.25 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.23 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834483 p.Glu314Asp missense_variant 0.25 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.25 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834543 c.1002C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.38 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834612 c.1071G>T synonymous_variant 0.38 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.32 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.37 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.38 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.16 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.13 pyrazinamide
rpsA 1834761 p.Phe407Tyr missense_variant 0.15 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.16 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834787 p.Ala416Asn missense_variant 0.15 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.14 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.21 isoniazid
kasA 2517965 c.-150C>G upstream_gene_variant 0.15 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.15 isoniazid
ahpC 2726597 c.405C>G synonymous_variant 0.13 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.16 isoniazid
ahpC 2726609 c.417C>T synonymous_variant 0.15 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.16 isoniazid
ahpC 2726645 c.453C>A synonymous_variant 0.16 isoniazid
ahpC 2726648 c.456T>C synonymous_variant 0.16 isoniazid
ahpC 2726651 c.459G>C synonymous_variant 0.16 isoniazid
ahpC 2726654 c.462G>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
ahpC 2726657 c.465A>T synonymous_variant 0.15 isoniazid
ahpC 2726669 c.477T>C synonymous_variant 0.15 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.15 isoniazid
ahpC 2726678 c.486G>C synonymous_variant 0.15 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
ahpC 2726684 c.492G>T synonymous_variant 0.15 isoniazid
ahpC 2726696 c.504C>T synonymous_variant 0.14 isoniazid
Rv2477c 2783085 p.Val320Met missense_variant 1.0 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3877629 c.879C>G synonymous_variant 0.15 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.16 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.16 rifampicin
rpoA 3877674 c.834C>T synonymous_variant 0.17 rifampicin
rpoA 3877677 c.831G>A synonymous_variant 0.2 rifampicin
rpoA 3877680 c.828G>T synonymous_variant 0.22 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877701 c.807G>T synonymous_variant 0.23 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877707 c.801G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.25 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.24 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.25 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.25 rifampicin
rpoA 3877749 c.759C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.28 rifampicin
rpoA 3877765 p.Ala248Ser missense_variant 0.28 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>T synonymous_variant 0.28 rifampicin
rpoA 3877791 c.717C>G synonymous_variant 0.28 rifampicin
rpoA 3877794 c.714G>T synonymous_variant 0.28 rifampicin
rpoA 3877815 c.693C>A synonymous_variant 0.28 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877821 c.687C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>T synonymous_variant 0.28 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.23 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.22 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.19 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.18 rifampicin
clpC1 4038587 c.2118C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038770 c.1935C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.29 pyrazinamide
clpC1 4038810 p.Gln632Ser missense_variant 0.3 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038839 c.1866G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.4 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.39 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.34 pyrazinamide
clpC1 4038926 c.1779G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.31 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038974 c.1731T>G synonymous_variant 0.31 pyrazinamide
clpC1 4038977 c.1728G>A synonymous_variant 0.32 pyrazinamide
clpC1 4038986 p.Asp573Glu missense_variant 0.34 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039019 c.1686G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.3 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039139 c.1566G>A synonymous_variant 0.25 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039154 c.1551G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039181 p.Leu508Phe missense_variant 0.14 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039603 p.Ala368Thr missense_variant 0.21 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039628 c.1077C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.27 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.27 pyrazinamide
clpC1 4039697 c.1008C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039811 c.894C>A synonymous_variant 0.21 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.2 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039916 c.789T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.25 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039940 c.765G>T synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.22 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039991 c.714G>A synonymous_variant 0.27 pyrazinamide Not assoc w R
clpC1 4039996 p.Glu237Gln missense_variant 0.24 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.25 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.25 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040066 c.639G>T synonymous_variant 0.17 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.15 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.21 pyrazinamide
glpK 4138558 p.Ala400Ser missense_variant 0.13 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138565 c.1191G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138568 c.1188A>C synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138571 c.1185C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138577 c.1179G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138604 c.1150_1152delTTGinsCTC synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138607 c.1149G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138631 c.1125C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138646 c.1110G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138655 c.1101G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R