TB-Profiler result

Run: DRR188519
Summary

Run ID: DRR188519

Sample name:

Date: 2024-10-05T05:40:52.590818

Number of reads: 1942265

Percentage reads mapped: 83.02

Median coverage: 95.0

Strain: lineage4.4.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.98
lineage4.4 Euro-American None 0.99
lineage4.4.2 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7045 c.-257C>T upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7418 c.117C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7526 c.225G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8366 c.1065G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8414 c.1113C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8417 c.1116C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8786 c.1485T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8788 p.Thr496Ser missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8840 c.1539C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8846 c.1545C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8876 c.1575C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8930 c.1629C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8954 c.1653G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8998 p.Leu566Trp missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
nusG 734439 c.186C>G synonymous_variant 0.16 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.16 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.17 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.17 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 0.18 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.16 rifampicin
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.15 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.17 rifampicin Uncertain significance
rpoB 760412 c.606C>T synonymous_variant 0.17 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760449 p.Thr215Leu missense_variant 0.16 rifampicin
rpoB 760460 c.654G>T synonymous_variant 0.16 rifampicin
rpoB 760463 c.657C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760497 c.691C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760532 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Arg missense_variant 0.15 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.15 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.14 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762006 c.2200_2202delCGCinsAGG synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.14 rifampicin Uncertain significance
rpoB 762029 c.2223C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.15 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.15 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.14 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.14 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.15 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>T synonymous_variant 0.15 rifampicin
rpoB 762209 c.2403C>T synonymous_variant 0.14 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.16 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.17 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>A synonymous_variant 0.16 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.16 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.15 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.14 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.15 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.16 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.16 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.16 rifampicin
rpoC 762407 c.-963G>C upstream_gene_variant 0.15 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.15 rifampicin
rpoC 763430 c.61A>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.15 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.17 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.14 rifampicin
rpoC 764085 p.Asn239Thr missense_variant 0.14 rifampicin Uncertain significance
rpoC 764098 c.729A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764134 c.765C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764152 c.783C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764169 p.Asn267Thr missense_variant 0.16 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.16 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Thr missense_variant 0.16 rifampicin Uncertain significance
rpoC 764213 p.Arg282Lys missense_variant 0.15 rifampicin Uncertain significance
rpoC 764254 c.885G>C synonymous_variant 0.16 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.15 rifampicin
rpoC 764266 c.897T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764279 p.Gln304Lys missense_variant 0.14 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.17 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.17 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.17 rifampicin
rpoC 764429 c.1060C>T synonymous_variant 0.16 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.15 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>G synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.16 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.19 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>A synonymous_variant 0.23 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.26 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.25 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>G synonymous_variant 0.23 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.21 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.18 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.18 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765404 p.Leu679Thr missense_variant 0.24 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765453 p.Ala695Val missense_variant 0.27 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCT synonymous_variant 0.22 rifampicin
rpoC 765553 c.2184C>G synonymous_variant 0.22 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.21 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.21 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.21 rifampicin
rpoC 765574 c.2205C>T synonymous_variant 0.21 rifampicin
rpoC 765607 c.2238C>G synonymous_variant 0.18 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.17 rifampicin Uncertain significance
rpoC 766456 c.3087C>G synonymous_variant 0.14 rifampicin
rpoC 766469 c.3100C>T synonymous_variant 0.14 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.16 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.16 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.16 rifampicin Uncertain significance
rpoC 766513 c.3144C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766517 p.Thr1050Ala missense_variant 0.18 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.18 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.18 rifampicin
rpoC 766537 c.3168G>A synonymous_variant 0.19 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.18 rifampicin
rpoC 766547 p.Arg1060Lys missense_variant 0.18 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.19 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.2 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.23 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.28 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.28 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.27 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.26 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.24 rifampicin
rpoC 766654 c.3285C>G synonymous_variant 0.23 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.23 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.23 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.23 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.24 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.24 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.26 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.25 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.25 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.23 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.23 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.21 rifampicin
rpoC 766759 c.3390G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766765 c.3396A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.18 rifampicin
rpoC 766775 p.Arg1136Asn missense_variant 0.17 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.18 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>T synonymous_variant 0.17 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781709 c.150G>C synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.14 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.17 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.15 streptomycin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471996 n.151C>T non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472292 n.447A>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472302 n.457_458insT non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472310 n.465_466insG non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.36 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.36 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_175delGGTGCinsCCGGTG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474026 n.369C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474089 n.432C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474108 n.451C>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474116 n.459G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474127 n.470G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474287 n.630_644delTCCTTTTCCTCTCCGinsCTCCTTT non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474303 n.646A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474415 n.760_765delACACGC non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474426 n.769T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474428 n.771C>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474430 n.773C>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474432 n.775C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474438 n.781delAinsGT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474711 n.1054_1055insA non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474716 n.1059_1060delAAinsG non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474952 n.1296delC non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474956 n.1299C>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474957 n.1301_1308delACCTTGTG non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474968 n.1311G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474969 n.1312G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474972 n.1315delGinsAT non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474990 n.1333C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474991 n.1334T>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474995 n.1338T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474997 n.1340A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474999 n.1342C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475008 n.1351C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475010 n.1353G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475015 n.1358_1360delCCGinsTCTA non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475037 n.1380T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475379 n.1722G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475380 n.1724_1725delGA non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475399 n.1742T>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475400 n.1743C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid Uncertain significance
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475405 n.1748A>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475428 n.1771G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475619 n.1962C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475621 n.1964T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
inhA 1674656 p.Ser152Thr missense_variant 0.16 isoniazid
ethionamide
rpsA 1833802 c.261A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833814 c.273C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.2 pyrazinamide
rpsA 1833904 p.Glu121Asp missense_variant 0.22 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.13 pyrazinamide
rpsA 1834066 c.525G>A synonymous_variant 0.15 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834154 p.Asn205His missense_variant 0.15 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834172 p.Ile211Val missense_variant 0.14 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.19 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834285 c.744G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834364 c.823_825delTCAinsAGC synonymous_variant 0.19 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834527 p.Arg329Gln missense_variant 0.21 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.2 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.16 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834650 p.Thr370Asn missense_variant 0.18 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.16 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.15 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 0.99 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2156588 c.-479_-478delGT upstream_gene_variant 1.0 isoniazid Uncertain significance
PPE35 2169820 p.Asn265Asp missense_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518606 c.492G>C synonymous_variant 0.14 isoniazid
kasA 2518618 c.504G>C synonymous_variant 0.16 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.15 isoniazid
kasA 2518636 c.522C>A synonymous_variant 0.14 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.15 isoniazid
folC 2747461 c.138C>T synonymous_variant 0.99 para-aminosalicylic_acid
Rv2477c 2783386 c.657G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.17 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783626 p.Ala139Ser missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783646 p.Asp133Asn missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3066099 p.Met31Ile missense_variant 0.98 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624817 p.Glu32Lys missense_variant 1.0 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrA 3627080 c.270T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3627095 c.-482G>A upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
rpoA 3877707 c.801G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.14 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.15 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.15 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.15 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.16 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.17 rifampicin
rpoA 3878093 p.Val139Ile missense_variant 0.18 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.18 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.18 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.17 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.21 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.2 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.19 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.18 rifampicin
rpoA 3878184 c.324C>G synonymous_variant 0.17 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878262 p.Ser82Gly missense_variant 0.18 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.19 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.17 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878853 c.-346G>A upstream_gene_variant 0.14 rifampicin
rpoA 3878873 c.-366G>A upstream_gene_variant 0.16 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878893 c.-388_-386delCACinsAAG upstream_gene_variant 0.17 rifampicin
rpoA 3878899 c.-392C>G upstream_gene_variant 0.15 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.17 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.16 rifampicin
rpoA 3878947 c.-440G>T upstream_gene_variant 0.18 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.16 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878977 c.-470C>G upstream_gene_variant 0.15 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.15 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.14 rifampicin
rpoA 3879019 c.-512T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.14 rifampicin
rpoA 3879032 c.-528_-525delAGCCinsGG upstream_gene_variant 0.15 rifampicin
rpoA 3879046 c.-539G>A upstream_gene_variant 0.15 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.14 rifampicin
clpC1 4038683 c.2022T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038707 c.1998C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038726 p.Thr660Cys missense_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038896 c.1809C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.21 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.23 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039001 p.Asn568Glu missense_variant 0.21 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039037 c.1668T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039127 p.Lys526Asn missense_variant 0.22 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039139 p.Glu522Asp missense_variant 0.21 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039165 c.1540C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039166 c.1539G>A synonymous_variant 0.22 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.22 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.18 pyrazinamide
clpC1 4039286 c.1417_1419delCTTinsTTG synonymous_variant 0.18 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.21 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.19 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039394 c.1311G>T synonymous_variant 0.18 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039601 c.1104G>T synonymous_variant 0.14 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039733 c.972G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040126 c.579C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040135 c.570C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040165 c.540G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.17 pyrazinamide
clpC1 4040225 c.480A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040240 c.465C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.16 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.427_429delTCCinsAGT synonymous_variant 0.15 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.15 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040351 c.354C>T synonymous_variant 0.14 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040363 c.342A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040369 c.336C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.16 pyrazinamide
clpC1 4040540 c.165G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040573 c.132T>G synonymous_variant 0.18 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.14 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCTT synonymous_variant 0.15 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.15 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.15 pyrazinamide
embC 4238963 c.-900C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4246508 c.3276G>A synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4268928 c.906C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269375 c.459G>A synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326066 p.Arg470Cys missense_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin