TB-Profiler result

Run: SRR13583478
Summary

Run ID: SRR13583478

Sample name:

Date: 2024-04-16T08:16:19.353537

Number of reads: 1042058

Percentage reads mapped: 64.41

Median coverage: 31.0

Strain: lineage4.3.4.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.88
lineage4.3.4.1 Euro-American (LAM) RD174 0.88
lineage4 Euro-American None 0.98
lineage4.3.4 Euro-American (LAM) RD174 0.89
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ile335Thr Mutation from literature
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.718_720delGAGinsAA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.604_606delTCGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.913_915delGCCinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1018_1020delGGCinsCT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1078_1080delTTGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491500 c.718_720delGAGinsAA frameshift_variant&missense_variant 0.31 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.33 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303534 c.604_606delTCGinsGC frameshift_variant&missense_variant 0.39 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.26 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303843 c.913_915delGCCinsAG frameshift_variant&missense_variant 0.2 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303948 c.1018_1020delGGCinsCT frameshift_variant&missense_variant 0.34 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304008 c.1078_1080delTTGinsCC frameshift_variant&missense_variant 0.42 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance Mutation from literature
katG 2155108 p.Ile335Thr missense_variant 0.19 isoniazid Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 690 c.690G>C synonymous_variant 0.39 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.45 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.45 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.36 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.38 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.4 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.38 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.39 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.37 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.41 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.41 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.34 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.33 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.34 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.34 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.34 isoniazid Not assoc w R - Interim
dnaA 877 c.877T>C synonymous_variant 0.32 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.33 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.31 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.27 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.19 isoniazid
dnaA 927 c.927G>A synonymous_variant 0.18 isoniazid
dnaA 1014 c.1014C>G synonymous_variant 0.35 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.33 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.37 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.4 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.4 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.38 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.38 isoniazid
dnaA 1122 c.1122C>T synonymous_variant 0.35 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.3 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.3 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.25 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1185 c.1185C>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1188 c.1188G>A synonymous_variant 0.26 isoniazid
gyrB 6238 c.999G>A synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.69 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrB 6283 c.1044C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6412 c.-890G>A upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6751 c.-551G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.29 levofloxacin
moxifloxacin
gyrB 6797 p.Gly520Thr missense_variant 0.29 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.3 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6856 c.1617T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6889 c.-413G>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6913 c.1674C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6919 c.1680T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6950 c.1711_1713delCTCinsTG frameshift_variant&missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6988 c.-314C>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7000 c.-302C>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8189 c.888G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8684 c.1383G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8730 c.1429_1431delGGGinsCC frameshift_variant&missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 c.1479C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9191 c.1890G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9299 c.1998G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491121 c.339A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491289 c.507C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491292 c.510G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491307 c.525C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491370 c.588C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491487 c.705C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491535 c.753G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491541 c.759G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491583 c.801G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
mshA 574650 c.-698A>C upstream_gene_variant 0.19 ethionamide
isoniazid
mshA 574655 c.-693C>G upstream_gene_variant 0.18 ethionamide
isoniazid
mshA 574671 c.-677_-675delGCAinsCTG upstream_gene_variant 0.22 ethionamide
isoniazid
mshA 574676 c.-672G>C upstream_gene_variant 0.23 ethionamide
isoniazid
mshA 574683 c.-665T>C upstream_gene_variant 0.23 ethionamide
isoniazid Uncertain significance
mshA 574688 c.-660G>C upstream_gene_variant 0.24 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 574694 c.-654C>G upstream_gene_variant 0.26 ethionamide
isoniazid
mshA 574718 c.-630A>C upstream_gene_variant 0.24 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 574731 c.-617A>G upstream_gene_variant 0.23 ethionamide
isoniazid
mshA 574739 c.-609T>C upstream_gene_variant 0.27 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575617 c.270C>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575629 c.282A>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575632 c.285G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575635 c.288A>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575638 c.291T>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.3 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575662 c.315C>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575692 c.345G>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.19 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.18 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
mshA 575812 c.465C>T synonymous_variant 0.18 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619558 c.-333G>T upstream_gene_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>T upstream_gene_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 619606 c.-285C>T upstream_gene_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619668 c.-223_-222delCGinsGC upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>T upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620659 p.Arg257Ser missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAT frameshift_variant&missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
Rv0565c 656924 p.Ile183Val missense_variant 0.23 ethionamide
Rv0565c 656935 p.Thr179Asp missense_variant 0.21 ethionamide
Rv0565c 656946 c.525T>C synonymous_variant 0.22 ethionamide
Rv0565c 656952 c.519A>G synonymous_variant 0.25 ethionamide
Rv0565c 656967 c.504T>C synonymous_variant 0.26 ethionamide
Rv0565c 656973 c.498A>G synonymous_variant 0.27 ethionamide
Rv0565c 656978 p.Ala165Thr missense_variant 0.29 ethionamide
Rv0565c 656982 p.Gly163Thr missense_variant 0.29 ethionamide
Rv0565c 656985 c.486T>C synonymous_variant 0.27 ethionamide
Rv0565c 656990 p.Lys161Glu missense_variant 0.29 ethionamide
Rv0565c 657000 p.Gly157Pro missense_variant 0.3 ethionamide
Rv0565c 657027 c.444T>C synonymous_variant 0.32 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.25 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.26 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.25 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.24 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.41 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.35 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.36 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.36 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.38 ethionamide Uncertain significance
Rv0565c 657340 p.Ala44Glu missense_variant 0.4 ethionamide
Rv0565c 657342 c.129T>C synonymous_variant 0.4 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.4 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.42 ethionamide
Rv0565c 657354 p.Ile39Met missense_variant 0.44 ethionamide
Rv0565c 657363 c.108C>G synonymous_variant 0.45 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.25 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.2 ethionamide
hadA 732295 c.366G>C synonymous_variant 0.23 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.23 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.23 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.24 isoniazid
hadA 732319 c.390G>A synonymous_variant 0.23 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.23 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.32 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.37 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.41 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.46 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.45 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.46 isoniazid
nusG 734370 c.117A>G synonymous_variant 0.3 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.36 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.47 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.47 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.48 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.54 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.54 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.55 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.6 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.6 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.39 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.38 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.39 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.37 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.38 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.29 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.27 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.26 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.26 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.26 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.24 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.22 rifampicin Not assoc w R
nusG 734661 c.408A>C synonymous_variant 0.22 rifampicin
nusG 734664 c.411T>G synonymous_variant 0.22 rifampicin
rpoB 760091 c.285G>A synonymous_variant 0.26 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.3 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.41 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.44 rifampicin
rpoB 760145 c.339C>G synonymous_variant 0.44 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.49 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.41 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.42 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.41 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760358 c.552C>G synonymous_variant 0.49 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.47 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.44 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.44 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.41 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.41 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760442 c.636G>A synonymous_variant 0.43 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.31 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.34 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.31 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760755 p.His317Asn missense_variant 0.19 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.2 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.19 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.41 rifampicin
rpoB 761006 c.1200C>T synonymous_variant 0.46 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.46 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.43 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.42 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761286 c.1480C>T synonymous_variant 0.29 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.23 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.3 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.33 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.28 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761672 c.1866C>G synonymous_variant 0.3 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.27 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.24 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.24 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.24 rifampicin
rpoB 761730 c.1924_1926delGGCinsTGGG frameshift_variant&missense_variant 0.25 rifampicin
rpoB 761735 c.1929C>G synonymous_variant 0.25 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.3 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.29 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.33 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.3 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.31 rifampicin
rpoB 761789 c.1983G>C synonymous_variant 0.27 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.26 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.23 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.21 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.23 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.2 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.23 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.28 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.26 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.26 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.25 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.25 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.25 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.42 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.38 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.37 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.39 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.35 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.37 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.37 rifampicin
rpoB 762212 c.2406G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.38 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.38 rifampicin
rpoB 762260 c.2454C>T synonymous_variant 0.38 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>G synonymous_variant 0.39 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.41 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.4 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.4 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.39 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.33 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.36 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.36 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.39 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.37 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.34 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.31 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.28 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.24 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.27 rifampicin
rpoC 762521 c.-849C>G upstream_gene_variant 0.26 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.24 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.25 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.25 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.24 rifampicin
rpoC 762554 c.-816G>A upstream_gene_variant 0.24 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762971 c.3165G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.35 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.43 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.44 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>G upstream_gene_variant 0.23 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.21 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.21 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.19 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>A synonymous_variant 0.31 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.32 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.35 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.39 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.37 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.38 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.38 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.38 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.4 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.42 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.35 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.42 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.33 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.35 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.36 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.3 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.29 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.26 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.3 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.29 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.29 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.41 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763972 c.603C>T synonymous_variant 0.36 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.4 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.41 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.41 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.41 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.46 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.43 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.41 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.47 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.42 rifampicin
rpoC 764215 c.846A>G synonymous_variant 0.24 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.23 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.26 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.22 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.23 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764290 c.921C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764359 c.990C>G synonymous_variant 0.39 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.3 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.31 rifampicin
rpoC 764419 c.1050C>G synonymous_variant 0.32 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.28 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.25 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.29 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.23 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764506 c.1137C>T synonymous_variant 0.28 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.25 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.28 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.26 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.22 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.24 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>G synonymous_variant 0.3 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.38 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.29 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.24 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.21 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.95 rifampicin Not assoc w R
rpoC 765343 c.1974G>C synonymous_variant 0.18 rifampicin
rpoC 765352 c.1983G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765370 c.2001G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765371 c.2002C>T synonymous_variant 0.29 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.3 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.28 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.3 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.23 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.24 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.26 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.28 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.3 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.38 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.38 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.52 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.45 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.45 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.42 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.4 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.43 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.44 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.48 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.44 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.47 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.31 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.38 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.41 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.39 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.39 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.44 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.33 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.26 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.28 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.24 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766148 p.Thr927Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 766390 c.3021C>T synonymous_variant 0.2 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.42 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.42 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.38 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.31 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.34 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.44 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.44 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.47 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.43 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.43 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.36 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.29 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.29 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.29 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.31 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.37 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.39 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.36 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.35 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.4 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.46 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.47 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.44 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.49 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.5 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.5 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.53 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.53 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.51 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.51 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767032 c.3663G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>T synonymous_variant 0.47 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.54 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.44 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.37 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.28 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.24 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777133 p.Val450Ile missense_variant 0.25 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.31 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 777173 c.1308C>G synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.29 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.27 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.25 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.32 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.29 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.28 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.29 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.31 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.32 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.36 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.34 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.34 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.37 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.37 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.36 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.34 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.34 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.3 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.31 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.29 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.27 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.3 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.31 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.36 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.18 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.3 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.3 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.31 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.38 linezolid
rplC 800576 c.-233C>T upstream_gene_variant 0.4 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.42 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.43 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.42 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.45 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.49 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.46 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.44 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.45 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.46 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.39 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.38 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.35 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.29 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.26 linezolid
fbiC 1303489 c.559C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303623 c.693C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303764 c.834C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304132 p.Ala401Gly missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304154 c.1224G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304162 p.Arg411Gln missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304166 c.1236A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304173 p.Val415Thr missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304178 c.1248G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304181 c.1251G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304199 c.1269C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.4 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>T synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.54 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304889 c.1959G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
sigE 1364434 p.Arg8Trp missense_variant 1.0 pyrazinamide Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474044 n.387C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474962 n.1305T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475006 n.1349A>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673574 c.-628C>G upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.19 ethionamide
isoniazid Uncertain significance
inhA 1673607 c.-595T>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.27 ethionamide
isoniazid
fabG1 1673641 p.Val68Ile missense_variant 0.26 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.21 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCT frameshift_variant&missense_variant 0.23 ethionamide
isoniazid
inhA 1674732 c.531C>T synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.27 ethionamide
isoniazid
inhA 1674753 c.552G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.25 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674774 c.573A>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.34 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674846 p.Ile215Met missense_variant 0.31 ethionamide
isoniazid
inhA 1674849 c.648G>A synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674861 c.660G>A synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674879 c.678T>G synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674904 c.703_705delGCGinsCC frameshift_variant&missense_variant 0.25 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.26 ethionamide
isoniazid
rpsA 1833610 c.69C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.47 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833772 c.231C>T synonymous_variant 0.45 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.39 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.32 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833868 c.327C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.32 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.29 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.38 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834480 c.939C>G synonymous_variant 0.54 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834546 c.1005T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.33 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.5 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.52 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.52 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.47 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.45 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.36 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.21 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.21 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.24 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.25 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.3 linezolid
tsnR 1853426 c.-180G>A upstream_gene_variant 0.28 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.29 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.29 linezolid
tsnR 1853444 c.-162C>G upstream_gene_variant 0.22 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.23 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.22 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 0.98 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918002 c.63A>G synonymous_variant 0.26 capreomycin
tlyA 1918026 c.87C>G synonymous_variant 0.23 capreomycin
ndh 2101894 c.1149T>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101912 c.1131G>C synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101918 c.1123_1125delAGGinsCA frameshift_variant&missense_variant 0.25 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101924 c.1119T>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
katG 2154279 c.1833C>T synonymous_variant 0.91 isoniazid Not assoc w R - Interim
katG 2155068 c.1044T>C synonymous_variant 0.21 isoniazid
katG 2155071 c.1041T>C synonymous_variant 0.21 isoniazid
katG 2155113 c.999C>G synonymous_variant 0.21 isoniazid
katG 2155119 c.991_993delAGTinsTCC synonymous_variant 0.21 isoniazid
katG 2155131 c.981A>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
katG 2155140 c.972C>G synonymous_variant 0.22 isoniazid
katG 2155144 p.Asn323Pro missense_variant 0.23 isoniazid
katG 2155152 c.960A>C synonymous_variant 0.22 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.25 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.29 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.27 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.27 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>C upstream_gene_variant 0.32 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.2 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.24 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.3 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.3 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.35 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.37 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.39 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.41 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.39 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.35 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.38 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.38 isoniazid
kasA 2518618 c.504G>T synonymous_variant 0.39 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.41 isoniazid
kasA 2518666 c.552G>A synonymous_variant 0.37 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.37 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.32 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.33 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.33 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.35 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.34 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.37 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.37 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.33 isoniazid
kasA 2518765 c.651G>C synonymous_variant 0.38 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.35 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.3 isoniazid
kasA 2518780 c.666G>A synonymous_variant 0.29 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.28 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.28 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.29 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.28 isoniazid
kasA 2518796 c.682C>A synonymous_variant 0.26 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.27 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.28 isoniazid
kasA 2518831 c.717C>T synonymous_variant 0.28 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.27 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.23 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.21 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.22 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.24 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.25 isoniazid
kasA 2518993 c.879C>A synonymous_variant 0.26 isoniazid
kasA 2519008 c.894C>G synonymous_variant 0.31 isoniazid
kasA 2519017 c.903G>C synonymous_variant 0.27 isoniazid
kasA 2519020 c.906G>C synonymous_variant 0.24 isoniazid
kasA 2519021 p.Ala303Lys missense_variant 0.24 isoniazid
kasA 2519027 c.913_915delATCinsGT frameshift_variant&missense_variant 0.22 isoniazid
kasA 2519035 c.921C>T synonymous_variant 0.26 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.29 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.26 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.28 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.29 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.34 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.33 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.33 isoniazid
kasA 2519113 c.999G>A synonymous_variant 0.35 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.35 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.34 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.28 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.33 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.35 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.35 isoniazid
kasA 2519196 p.Thr361Ser missense_variant 0.31 isoniazid
ahpC 2726633 c.441C>T synonymous_variant 0.34 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.34 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.32 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.24 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.26 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ahpC 2726693 c.501C>A synonymous_variant 0.29 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.29 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.27 isoniazid
folC 2747343 p.Val86Ile missense_variant 0.29 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.29 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.25 para-aminosalicylic_acid
folC 2747407 c.192T>C synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747434 c.165C>T synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747443 c.156G>C synonymous_variant 0.24 para-aminosalicylic_acid
Rv2477c 2782928 p.Thr372Glu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783083 c.960G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.26 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.27 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783287 c.756C>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783545 c.498C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTA frameshift_variant&missense_variant 0.33 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783656 c.387G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783968 c.75G>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064914 c.1278T>G synonymous_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064928 c.1264T>C synonymous_variant 0.44 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064932 c.1260T>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064935 c.1257A>G synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064941 c.1249_1251delCAAinsGG frameshift_variant&missense_variant 0.4 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064947 c.1245A>G synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064956 c.1234_1236delAGTinsCC frameshift_variant&missense_variant 0.41 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064962 c.1230C>G synonymous_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064973 p.Ala407Ser missense_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064995 c.1197C>G synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>G synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065007 c.1185G>C synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065013 c.1179G>C synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065016 c.1174_1176delAACinsCT frameshift_variant&missense_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065022 c.1170G>T synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1162_1164delGTGinsAT frameshift_variant&missense_variant 0.38 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065040 c.1152C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065421 c.771G>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065451 c.741G>A synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065457 c.735A>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065460 c.732G>T synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065463 c.729T>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065481 c.711T>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065487 c.705T>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065490 c.702A>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065493 c.699G>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065496 c.696G>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065499 c.693A>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065508 c.684T>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065511 c.681G>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065517 c.675C>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065520 c.672G>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065532 c.660A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065535 c.657C>T synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065547 c.645A>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065985 c.207C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065988 c.204A>G synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066002 p.Met64Leu missense_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066003 c.189C>T synonymous_variant 0.32 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin
isoniazid
Rv2752c 3066009 c.183G>C synonymous_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066018 c.174T>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.48 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066069 c.121_123delTTGinsCC frameshift_variant&missense_variant 0.43 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066075 c.117A>G synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066090 c.100_102delTTCinsCG frameshift_variant&missense_variant 0.33 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066118 p.Asn25Ser missense_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067349 c.597G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067682 c.264G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067715 c.231C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.16 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.27 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.27 para-aminosalicylic_acid
thyA 3073868 p.Thr202Ala missense_variant 0.86 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 0.89 pyrazinamide Not assoc w R
Rv3236c 3612349 c.768A>C synonymous_variant 0.26 pyrazinamide
Rv3236c 3612388 c.729T>C synonymous_variant 0.24 pyrazinamide
Rv3236c 3612715 c.402G>C synonymous_variant 0.19 pyrazinamide
Rv3236c 3612721 c.396G>C synonymous_variant 0.19 pyrazinamide
Rv3236c 3612724 c.393T>C synonymous_variant 0.2 pyrazinamide
Rv3236c 3612730 c.387C>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
Rv3236c 3612736 c.381T>C synonymous_variant 0.19 pyrazinamide
Rv3236c 3612748 c.369G>C synonymous_variant 0.2 pyrazinamide
lpqB 3624656 c.255C>T synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624701 c.210T>C synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.31 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.33 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3624776 c.135T>C synonymous_variant 0.26 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625093 p.Glu507Asp missense_variant 0.22 bedaquiline
rifampicin
lpqB 3625099 c.-189C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625105 c.1509C>A synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625117 c.-207T>G upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.31 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.31 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.33 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625206 p.Ser470Ala missense_variant 0.36 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625240 c.-330T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625243 c.-333T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.43 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.41 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.47 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.51 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.33 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625777 c.-867C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625797 p.Val273Met missense_variant 0.36 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625803 c.-893C>T upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625882 c.-972G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625909 c.-999T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626101 p.Gln171His missense_variant 0.32 bedaquiline
rifampicin
mtrB 3626107 c.507G>C synonymous_variant 0.33 bedaquiline
rifampicin
mtrB 3626110 c.504C>G synonymous_variant 0.33 bedaquiline
rifampicin
mtrB 3626116 c.498G>A synonymous_variant 0.35 bedaquiline
rifampicin
mtrB 3626124 p.Ala164Ser missense_variant 0.41 bedaquiline
rifampicin
mtrB 3626125 c.489C>G synonymous_variant 0.39 bedaquiline
rifampicin
mtrB 3626146 c.468C>T synonymous_variant 0.36 bedaquiline
rifampicin
mtrB 3626155 c.459G>C synonymous_variant 0.39 bedaquiline
rifampicin
mtrB 3626158 c.456C>T synonymous_variant 0.39 bedaquiline
rifampicin
mtrB 3626170 c.444T>C synonymous_variant 0.37 bedaquiline
rifampicin
mtrB 3626185 c.429T>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626188 c.424_426delTCTinsAC frameshift_variant&missense_variant 0.32 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626191 c.423C>G synonymous_variant 0.33 bedaquiline
rifampicin
mtrB 3626194 c.420T>G synonymous_variant 0.32 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626206 c.408T>C synonymous_variant 0.3 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626209 c.405T>C synonymous_variant 0.3 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.29 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626885 c.-272A>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626900 c.-287G>A upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrB 3627125 c.-512C>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627175 c.175C>T synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.162A>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627196 c.-583C>T upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.33 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.25 bedaquiline
rifampicin
mtrB 3627360 c.-747G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
fbiB 3640920 c.-615A>T upstream_gene_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642560 c.1026T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642566 c.1032A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiB 3642572 c.1038A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642581 c.1047A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3642587 p.Met351Ile missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiB 3642596 c.1062C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642609 c.1075_1076delAGinsTC synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
alr 3840944 c.477T>C synonymous_variant 0.25 cycloserine
alr 3840947 c.474G>C synonymous_variant 0.28 cycloserine
alr 3840959 c.462G>C synonymous_variant 0.31 cycloserine
alr 3840962 c.459G>C synonymous_variant 0.31 cycloserine
alr 3840968 c.453G>C synonymous_variant 0.3 cycloserine
alr 3840977 c.444C>G synonymous_variant 0.27 cycloserine
alr 3840980 c.441G>C synonymous_variant 0.27 cycloserine
alr 3840994 p.His143Asp missense_variant 0.33 cycloserine
alr 3840997 c.424T>C synonymous_variant 0.33 cycloserine
alr 3841001 c.420A>G synonymous_variant 0.34 cycloserine
alr 3841010 c.411A>G synonymous_variant 0.33 cycloserine
alr 3841017 p.Leu135Glu missense_variant 0.32 cycloserine
alr 3841022 c.399C>G synonymous_variant 0.31 cycloserine
alr 3841028 c.393G>C synonymous_variant 0.31 cycloserine
alr 3841033 p.Val130Ile missense_variant 0.31 cycloserine
alr 3841037 c.382_384delGTGinsAC frameshift_variant&missense_variant 0.3 cycloserine
alr 3841059 p.Gly121Ala missense_variant 0.3 cycloserine
rpoA 3877488 c.1020C>T synonymous_variant 0.27 rifampicin
rpoA 3877494 p.Glu338Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.29 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.25 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.28 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.33 rifampicin
rpoA 3877560 c.948C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877571 p.Pro313Ala missense_variant 0.39 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.52 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.57 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.57 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.51 rifampicin
rpoA 3877794 c.714G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.58 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.54 rifampicin
rpoA 3877881 c.627G>A synonymous_variant 0.5 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.46 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.46 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.44 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.44 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877989 c.519A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.25 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.24 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.25 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.25 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>T synonymous_variant 0.25 rifampicin
rpoA 3878046 c.462T>A synonymous_variant 0.23 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.23 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.23 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.24 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.23 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.24 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.32 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.32 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.35 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.39 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.37 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.38 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.39 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.38 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.42 rifampicin
rpoA 3878175 c.333G>T synonymous_variant 0.43 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.46 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.47 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.43 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.38 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.33 rifampicin
rpoA 3878331 c.177A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>C synonymous_variant 0.23 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.25 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.3 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.3 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.3 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.3 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.3 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.29 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.28 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.28 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.26 rifampicin
rpoA 3878460 c.48C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878716 c.-209C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.26 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.28 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.29 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878761 c.-254G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.33 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.34 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.35 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.25 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.2 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.32 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.4 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.38 rifampicin
rpoA 3879033 c.-526C>T upstream_gene_variant 0.38 rifampicin
rpoA 3879034 c.-527G>A upstream_gene_variant 0.38 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.43 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.47 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.44 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.43 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.39 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.39 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.4 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.35 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.31 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.23 rifampicin
ddn 3986621 c.-223G>C upstream_gene_variant 0.35 delamanid
pretomanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.27 delamanid
pretomanid
clpC1 4038287 c.2418C>T synonymous_variant 0.6 pyrazinamide Not assoc w R
clpC1 4038347 c.2358G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.26 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.23 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.19 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.2 pyrazinamide
clpC1 4038458 c.2247G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038486 p.Gly740Thr missense_variant 0.22 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.24 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038815 c.1890G>A synonymous_variant 0.26 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.39 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.41 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.47 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039043 c.1662G>T synonymous_variant 0.4 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.36 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039193 c.1512C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>C synonymous_variant 0.41 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.38 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.37 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.31 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.26 pyrazinamide
clpC1 4039576 p.Ala377Pro missense_variant 0.35 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>T synonymous_variant 0.41 pyrazinamide
clpC1 4039610 c.1095G>T synonymous_variant 0.42 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.41 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039756 c.949C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.25 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.25 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039964 c.741C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039979 c.726C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040087 c.618G>T synonymous_variant 0.33 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.28 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.23 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.24 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.25 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
panD 4044635 c.-354G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044643 c.-362G>T upstream_gene_variant 0.21 pyrazinamide
panD 4044650 c.-369G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044653 c.-372C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044662 c.-381C>G upstream_gene_variant 0.2 pyrazinamide
panD 4044668 c.-387G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044677 c.-396T>C upstream_gene_variant 0.2 pyrazinamide
panD 4044682 c.-401C>A upstream_gene_variant 0.22 pyrazinamide
panD 4044692 c.-411G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044700 c.-419C>A upstream_gene_variant 0.22 pyrazinamide
panD 4044704 c.-423G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044709 c.-428A>G upstream_gene_variant 0.21 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.22 pyrazinamide
panD 4044737 c.-456T>G upstream_gene_variant 0.2 pyrazinamide
panD 4044748 c.-467G>A upstream_gene_variant 0.19 pyrazinamide
glpK 4138670 c.1086G>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138808 c.948G>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138822 p.Asn312Asp missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138829 c.927A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240671 p.Thr270Ile missense_variant 0.19 ethambutol Not assoc w R
embC 4240675 c.813C>T synonymous_variant 0.19 ethambutol
embC 4240702 c.840G>A synonymous_variant 0.18 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.23 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.23 ethambutol
embC 4241081 c.1219C>T synonymous_variant 0.29 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.33 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.36 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.36 ethambutol
embC 4241131 c.1269G>A synonymous_variant 0.38 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.32 ethambutol
embC 4241158 c.1296T>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embC 4241161 c.1299C>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.3 ethambutol
embC 4241374 c.1512T>C synonymous_variant 0.17 ethambutol
embC 4241380 c.1518A>C synonymous_variant 0.19 ethambutol
embC 4241383 c.1521G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241394 p.Lys511Ser missense_variant 0.23 ethambutol
embC 4241443 c.1581C>T synonymous_variant 0.31 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.86 ethambutol Not assoc w R
embA 4242739 c.-494C>G upstream_gene_variant 0.23 ethambutol
embA 4242742 c.-491C>G upstream_gene_variant 0.24 ethambutol
embA 4242745 c.-488A>G upstream_gene_variant 0.24 ethambutol
embC 4242746 c.2884_2886delCCAinsTG frameshift_variant&stop_gained 0.24 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.22 ethambutol
embC 4242762 p.Arg967Gln missense_variant 0.21 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.21 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.24 ethambutol
embC 4242791 c.2929_2931delGCAinsTG frameshift_variant&stop_gained 0.21 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.22 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.22 ethambutol
embA 4242809 c.-424C>T upstream_gene_variant 0.21 ethambutol
embA 4242820 c.-413G>C upstream_gene_variant 0.21 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.19 ethambutol
embA 4242832 c.-401A>G upstream_gene_variant 0.17 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.19 ethambutol
embA 4245101 c.1869G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embA 4245137 c.1905T>C synonymous_variant 0.21 ethambutol
embB 4247879 c.1366_1368delGTGinsAC frameshift_variant&missense_variant 0.18 ethambutol
embB 4247893 c.1380C>A synonymous_variant 0.21 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.19 ethambutol
embB 4248088 c.1575C>T synonymous_variant 0.18 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.22 ethambutol
embB 4248100 c.1587C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248106 c.1593C>T synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248115 c.1602C>T synonymous_variant 0.19 ethambutol Not assoc w R
embB 4248118 c.1605T>C synonymous_variant 0.2 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248160 c.1647C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248169 c.1656C>G synonymous_variant 0.27 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.26 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.27 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.27 ethambutol
embB 4248206 c.1693_1695delAGCinsGA frameshift_variant&missense_variant 0.27 ethambutol
embB 4248220 c.1707A>T synonymous_variant 0.26 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.26 ethambutol
embB 4248307 c.1794G>C synonymous_variant 0.29 ethambutol
embB 4248416 p.Leu635Val missense_variant 0.28 ethambutol
embB 4248424 c.1911G>C synonymous_variant 0.26 ethambutol
embB 4248475 c.1962G>A synonymous_variant 0.21 ethambutol
embB 4249417 c.2904A>T synonymous_variant 0.17 ethambutol
aftB 4268105 c.732T>C synonymous_variant 0.26 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 0.9 streptomycin Not assoc w R