Run ID: SRR28351339
Sample name:
Date: 2024-05-22T16:52:33.007982
Number of reads: 438611
Percentage reads mapped: 69.89
Median coverage: 1.0
Strain: lineage4
Spoligotype:
Drug-resistance: MDR-TB
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage4 | Euro-American | None | 0.99 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | rpoB | c.1327_1329delTTGinsCC | Assoc w R - Interim | Expert rule: Non-silent variants in RRDR of rpoB |
| isoniazid | katG | c.451_453delGTCinsCG | Assoc w R | High-level resistance |
| c.343_345delATCinsGG | Assoc w R | High-level resistance | ||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | fgd1 | c.730_732delAACinsGG | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| fbiB | c.1099_1101delGACinsCG | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| fgd1 | 491512 | c.730_732delAACinsGG | frameshift_variant&missense_variant | 1.0 | delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
| rpoB | 761133 | c.1327_1329delTTGinsCC | frameshift_variant&missense_variant | 1.0 | rifampicin | Assoc w R - Interim | Expert rule: Non-silent variants in RRDR of rpoB |
| katG | 2155659 | c.451_453delGTCinsCG | frameshift_variant&missense_variant | 0.91 | isoniazid | Assoc w R | High-level resistance |
| katG | 2155767 | c.343_345delATCinsGG | frameshift_variant&missense_variant | 0.97 | isoniazid | Assoc w R | High-level resistance |
| fbiB | 3642633 | c.1099_1101delGACinsCG | frameshift_variant&missense_variant | 1.0 | delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| dnaA | 1122 | c.1122C>T | synonymous_variant | 0.96 | isoniazid | |
| dnaA | 1143 | c.1143G>C | synonymous_variant | 0.97 | isoniazid | |
| dnaA | 1152 | c.1152A>G | synonymous_variant | 0.97 | isoniazid | |
| dnaA | 1153 | c.1153T>C | synonymous_variant | 0.97 | isoniazid | |
| dnaA | 1176 | c.1176A>G | synonymous_variant | 0.97 | isoniazid | |
| dnaA | 1189 | c.1189_1191delATTinsGG | frameshift_variant&missense_variant | 1.0 | isoniazid | Uncertain significance |
| dnaA | 1195 | c.1195_1197delCTTinsTG | frameshift_variant&missense_variant | 0.97 | isoniazid | Uncertain significance |
| dnaA | 1206 | c.1206G>C | synonymous_variant | 0.97 | isoniazid | Not assoc w R - Interim |
| dnaA | 1220 | p.Asn407Thr | missense_variant | 0.94 | isoniazid | |
| dnaA | 1230 | c.1230A>G | synonymous_variant | 0.94 | isoniazid | |
| dnaA | 1237 | p.Ala413Thr | missense_variant | 0.94 | isoniazid | Uncertain significance |
| dnaA | 1243 | p.Thr415Ala | missense_variant | 0.93 | isoniazid | Uncertain significance |
| dnaA | 1254 | c.1254T>G | synonymous_variant | 0.94 | isoniazid | |
| dnaA | 1266 | c.1266A>G | synonymous_variant | 0.97 | isoniazid | |
| dnaA | 1275 | p.Asp425Glu | missense_variant | 0.95 | isoniazid | |
| dnaA | 1278 | c.1278T>C | synonymous_variant | 0.95 | isoniazid | |
| dnaA | 1281 | c.1281C>G | synonymous_variant | 0.95 | isoniazid | |
| dnaA | 1287 | c.1287A>G | synonymous_variant | 0.95 | isoniazid | |
| dnaA | 1290 | c.1290G>A | synonymous_variant | 0.95 | isoniazid | |
| dnaA | 1293 | c.1293T>G | synonymous_variant | 0.95 | isoniazid | |
| dnaA | 1299 | c.1299G>C | synonymous_variant | 0.95 | isoniazid | Not assoc w R - Interim |
| dnaA | 1318 | c.1318C>T | synonymous_variant | 0.94 | isoniazid | |
| dnaA | 1323 | c.1323C>G | synonymous_variant | 0.94 | isoniazid | |
| dnaA | 1329 | c.1329A>C | synonymous_variant | 0.89 | isoniazid | |
| dnaA | 1332 | c.1332A>G | synonymous_variant | 0.89 | isoniazid | |
| dnaA | 1338 | c.1338T>C | synonymous_variant | 0.89 | isoniazid | |
| dnaA | 1341 | c.1341G>C | synonymous_variant | 0.89 | isoniazid | |
| dnaA | 1353 | c.1353T>C | synonymous_variant | 0.89 | isoniazid | |
| dnaA | 1356 | c.1356T>G | synonymous_variant | 0.89 | isoniazid | |
| dnaA | 1362 | c.1362C>G | synonymous_variant | 0.94 | isoniazid | Not assoc w R - Interim |
| dnaA | 1371 | c.1371T>G | synonymous_variant | 0.92 | isoniazid | |
| dnaA | 1374 | c.1374G>C | synonymous_variant | 0.92 | isoniazid | |
| dnaA | 1375 | c.1375T>C | synonymous_variant | 0.92 | isoniazid | |
| dnaA | 1383 | c.1383A>G | synonymous_variant | 0.92 | isoniazid | |
| dnaA | 1392 | c.1392A>G | synonymous_variant | 0.91 | isoniazid | |
| gyrB | 6242 | p.Arg335Lys | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6250 | c.1011A>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6253 | c.1014G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6268 | c.1029C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6280 | c.1041T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6289 | c.1050C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6292 | c.1053G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6298 | c.1059C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6307 | c.1068T>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6326 | p.Ser363Ala | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6331 | c.-971A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6346 | c.-956C>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6362 | c.1123_1125delTTGinsCC | frameshift_variant&missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | ||||||
| gyrB | 6551 | c.1312T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6577 | c.1338T>C | synonymous_variant | 0.89 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 6580 | c.-722C>G | upstream_gene_variant | 0.89 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6583 | c.-719G>C | upstream_gene_variant | 0.83 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6594 | p.Lys452Arg | missense_variant | 0.89 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6598 | c.-704C>G | upstream_gene_variant | 0.89 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6604 | c.-698G>T | upstream_gene_variant | 0.88 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6610 | c.-692C>G | upstream_gene_variant | 0.89 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6613 | c.-689A>G | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6622 | c.-680C>T | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6634 | c.-668T>C | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6637 | c.-665T>G | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6640 | c.-662A>C | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6643 | c.-659A>G | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6649 | c.-653T>C | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6652 | c.-650C>G | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6655 | c.-647T>C | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6670 | c.-632G>C | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6673 | c.-629A>C | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6676 | c.-626T>G | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6680 | c.1441C>T | synonymous_variant | 0.9 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 7057 | c.1818C>T | synonymous_variant | 0.83 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 7060 | c.1821T>C | synonymous_variant | 0.88 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7066 | c.-236G>C | upstream_gene_variant | 0.91 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7078 | c.-224A>G | upstream_gene_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7081 | c.-221T>C | upstream_gene_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7084 | c.-218A>G | upstream_gene_variant | 0.98 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 7093 | c.1854T>C | synonymous_variant | 0.98 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7099 | c.-203G>A | upstream_gene_variant | 0.98 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 7100 | c.1861T>C | synonymous_variant | 0.97 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7108 | c.-194G>A | upstream_gene_variant | 0.99 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7123 | c.-179C>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 7124 | c.1885_1887delTCGinsAA | frameshift_variant&missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | ||||||
| gyrA | 7129 | c.-173T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7132 | c.-170T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7153 | c.-149G>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 7156 | c.1917C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7162 | c.-140C>A | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7168 | c.-134C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7201 | c.-101G>A | upstream_gene_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 7210 | p.Asp657Glu | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7216 | c.-86G>A | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7225 | c.-77T>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7231 | c.-71C>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7243 | c.-59G>A | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 7246 | c.2007T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | ||||||
| gyrA | 7433 | c.132G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7442 | c.141G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7457 | c.156T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7460 | c.159C>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7469 | c.168C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7472 | c.171T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | ||||||
| gyrA | 7475 | c.174A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7480 | p.Phe60Tyr | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7484 | c.183T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7487 | c.186C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7496 | c.195C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7517 | c.216G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7526 | c.225G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7532 | c.231T>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7541 | c.240C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7547 | c.246C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7553 | c.252C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7565 | c.264C>T | synonymous_variant | 0.97 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7592 | c.291G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8603 | c.1302A>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8609 | c.1308G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8619 | c.1318T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8624 | c.1323G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8627 | c.1326C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8628 | c.1327C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8636 | c.1335A>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8645 | c.1344C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8649 | p.Arg450Lys | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8663 | c.1362C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8672 | c.1371A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8681 | c.1380C>T | synonymous_variant | 0.98 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8693 | c.1392T>C | synonymous_variant | 0.99 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8696 | c.1395G>C | synonymous_variant | 0.98 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8711 | c.1410A>C | synonymous_variant | 0.98 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8717 | c.1416C>G | synonymous_variant | 0.98 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8720 | c.1419G>A | synonymous_variant | 0.98 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8731 | p.Gly477Ala | missense_variant | 0.95 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8747 | c.1446A>G | synonymous_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8750 | c.1449C>G | synonymous_variant | 0.95 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8756 | c.1455A>G | synonymous_variant | 0.96 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8761 | p.Val487Ala | missense_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8767 | p.Arg489Lys | missense_variant | 0.96 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| gyrA | 8777 | c.1476C>T | synonymous_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8786 | c.1485T>G | synonymous_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8796 | p.Ile499Val | missense_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8799 | p.Ala500Pro | missense_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8810 | c.1509A>C | synonymous_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8825 | c.1524G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8829 | c.1528T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8843 | c.1542G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8852 | c.1551T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8858 | c.1557T>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8867 | c.1566A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| fgd1 | 491472 | c.690A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491493 | c.711C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491496 | c.714C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491500 | p.Glu240Lys | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491508 | c.726A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491526 | c.744T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491536 | c.754C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491542 | c.760T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491547 | c.765A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491563 | c.781_783delAGCinsTCG | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491574 | c.792C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491601 | c.819T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491610 | c.828A>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| mshA | 575689 | c.342G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| mshA | 575695 | c.348C>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | Not assoc w R - Interim | |||||
| mshA | 575704 | c.357T>C | synonymous_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| mshA | 575705 | c.358T>C | synonymous_variant | 0.89 | ethionamide | |
| isoniazid | ||||||
| mshA | 575713 | c.366G>A | synonymous_variant | 0.89 | ethionamide | |
| isoniazid | ||||||
| mshA | 575719 | c.372C>T | synonymous_variant | 0.89 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| mshA | 575734 | c.387T>G | synonymous_variant | 0.9 | ethionamide | |
| isoniazid | ||||||
| mshA | 575737 | c.390T>C | synonymous_variant | 0.86 | ethionamide | |
| isoniazid | ||||||
| mshA | 575744 | p.Ala133Thr | missense_variant | 0.86 | ethionamide | |
| isoniazid | Uncertain significance | |||||
| mshA | 575749 | c.402C>G | synonymous_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| mshA | 575764 | c.417C>T | synonymous_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| mshA | 575771 | p.Val142Thr | missense_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| mshA | 575779 | c.432A>G | synonymous_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| mshA | 575782 | c.435G>C | synonymous_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| mshA | 575785 | c.438T>C | synonymous_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| mshA | 575788 | c.441C>T | synonymous_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| mshA | 575795 | p.Ile150Val | missense_variant | 0.91 | ethionamide | |
| isoniazid | ||||||
| mshA | 575842 | c.495G>C | synonymous_variant | 0.91 | ethionamide | |
| isoniazid | ||||||
| mshA | 575843 | p.Arg166Ser | missense_variant | 0.9 | ethionamide | |
| isoniazid | ||||||
| mshA | 575864 | c.517T>C | synonymous_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| mshA | 575878 | c.531A>G | synonymous_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| mshA | 575884 | c.537G>C | synonymous_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| mshA | 575893 | c.546C>G | synonymous_variant | 0.97 | ethionamide | |
| isoniazid | ||||||
| mshA | 575905 | c.558G>C | synonymous_variant | 0.97 | ethionamide | |
| isoniazid | ||||||
| mshA | 575916 | p.Asp190Ala | missense_variant | 0.97 | ethionamide | |
| isoniazid | ||||||
| mshA | 575920 | c.573C>T | synonymous_variant | 0.97 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| mshA | 575924 | p.Gly193Ser | missense_variant | 0.97 | ethionamide | |
| isoniazid | ||||||
| mshA | 575944 | c.597T>C | synonymous_variant | 0.96 | ethionamide | |
| isoniazid | ||||||
| mshA | 575945 | c.598_600delACGinsGA | frameshift_variant&missense_variant | 0.96 | ethionamide | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| mshA | 575950 | c.603C>G | synonymous_variant | 0.96 | ethionamide | |
| isoniazid | ||||||
| mshA | 575965 | c.618C>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | Not assoc w R - Interim | |||||
| ccsA | 620307 | c.417C>G | synonymous_variant | 0.91 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620311 | c.421_423delCTGinsGC | frameshift_variant&missense_variant | 0.92 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620319 | c.429C>T | synonymous_variant | 0.95 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620326 | c.436C>T | synonymous_variant | 0.98 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620335 | c.445_447delCTCinsTA | frameshift_variant&missense_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620358 | c.468C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620362 | p.Ala158Ser | missense_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620367 | c.477T>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620385 | c.495G>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620388 | c.498A>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620412 | c.522T>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620415 | c.525T>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620427 | c.537C>G | synonymous_variant | 0.98 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620430 | c.540C>T | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620439 | c.549T>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620445 | c.555A>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620454 | c.564C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620460 | c.570T>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620463 | c.573C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620577 | c.687C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620583 | c.693G>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620598 | c.708C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620604 | c.714C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620605 | c.715_717delGTTinsAC | frameshift_variant&missense_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620613 | c.723C>T | synonymous_variant | 0.98 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620619 | c.729G>T | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620625 | c.735A>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620631 | c.741T>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620649 | c.759A>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620661 | c.771C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620694 | c.804C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620698 | p.Val270Ile | missense_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620715 | c.825C>T | synonymous_variant | 0.98 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620724 | c.834C>T | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| rpoB | 760514 | c.708C>T | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoB | 760793 | c.987A>G | synonymous_variant | 0.97 | rifampicin | |
| rpoB | 760805 | c.999G>C | synonymous_variant | 0.98 | rifampicin | |
| rpoB | 760820 | c.1014T>C | synonymous_variant | 0.99 | rifampicin | |
| rpoB | 760826 | c.1020C>G | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoB | 760829 | c.1023C>T | synonymous_variant | 0.97 | rifampicin | |
| rpoB | 760830 | c.1024T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoB | 760841 | c.1035T>C | synonymous_variant | 0.98 | rifampicin | Not assoc w R - Interim |
| rpoB | 760845 | p.Thr347Ala | missense_variant | 0.99 | rifampicin | |
| rpoB | 760859 | c.1053T>C | synonymous_variant | 0.96 | rifampicin | |
| rpoB | 760862 | c.1056G>C | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoB | 760877 | c.1071G>C | synonymous_variant | 0.96 | rifampicin | |
| rpoB | 760883 | c.1077G>C | synonymous_variant | 0.96 | rifampicin | |
| rpoB | 760886 | c.1080A>G | synonymous_variant | 0.96 | rifampicin | |
| rpoB | 760887 | p.Thr361Val | missense_variant | 0.96 | rifampicin | Uncertain significance |
| rpoB | 760910 | c.1104C>T | synonymous_variant | 0.97 | rifampicin | Not assoc w R - Interim |
| rpoB | 760916 | c.1110C>T | synonymous_variant | 0.97 | rifampicin | Not assoc w R - Interim |
| rpoB | 760919 | c.1113C>T | synonymous_variant | 0.96 | rifampicin | |
| rpoB | 760925 | c.1119T>C | synonymous_variant | 0.97 | rifampicin | |
| rpoB | 760928 | c.1122G>C | synonymous_variant | 0.97 | rifampicin | Not assoc w R - Interim |
| rpoB | 760934 | c.1128C>T | synonymous_variant | 0.96 | rifampicin | |
| rpoB | 761063 | c.1257C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761097 | c.1291_1293delAGCinsTCG | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761102 | c.1296A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761126 | c.1320G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761132 | c.1326G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761147 | c.1341C>T | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoB | 761150 | c.1344A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761153 | c.1347G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761165 | c.1359G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761180 | c.1374A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761186 | c.1380G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761195 | c.1389G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761198 | c.1392G>T | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoB | 761217 | c.1411_1413delCCGinsGC | frameshift_variant&missense_variant | 0.99 | rifampicin | |
| rpoB | 761220 | c.1414_1416delTCGinsAGC | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761249 | c.1443A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761261 | c.1455G>T | synonymous_variant | 0.98 | rifampicin | Not assoc w R - Interim |
| rpoB | 761264 | c.1458C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761300 | c.1494G>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoB | 761318 | c.1512G>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoB | 761327 | c.1521A>G | synonymous_variant | 0.98 | rifampicin | Not assoc w R - Interim |
| rpoB | 761330 | c.1524G>C | synonymous_variant | 0.98 | rifampicin | |
| rpoB | 761339 | c.1533C>G | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoB | 761345 | c.1539G>T | synonymous_variant | 0.92 | rifampicin | |
| rpoB | 762782 | c.2976T>C | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoB | 762788 | c.2982G>C | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoB | 762789 | p.Leu995Met | missense_variant | 0.96 | rifampicin | Uncertain significance |
| rpoB | 762798 | p.Ala998Ser | missense_variant | 0.97 | rifampicin | |
| rpoB | 762812 | c.3006C>G | synonymous_variant | 0.98 | rifampicin | Not assoc w R - Interim |
| rpoB | 762814 | p.Met1003Thr | missense_variant | 0.98 | rifampicin | Uncertain significance |
| rpoB | 762818 | c.3012C>G | synonymous_variant | 0.98 | rifampicin | Not assoc w R - Interim |
| rpoC | 762827 | c.-543G>T | upstream_gene_variant | 0.97 | rifampicin | |
| rpoB | 762833 | c.3027C>T | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 762839 | c.-531G>A | upstream_gene_variant | 0.98 | rifampicin | |
| rpoB | 762857 | c.3051C>G | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoB | 762863 | c.3057T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoB | 762878 | p.Ile1024Met | missense_variant | 0.99 | rifampicin | |
| rpoB | 762879 | p.Met1025Leu | missense_variant | 0.99 | rifampicin | Uncertain significance |
| rpoC | 763621 | c.252C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763633 | c.264T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763660 | c.291T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763666 | c.297G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763675 | c.306C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763699 | c.330G>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 763702 | c.333C>G | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 763705 | c.336G>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 763709 | c.340C>T | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 763714 | c.345G>T | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 763717 | c.348T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 763723 | c.354G>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 763741 | c.372C>T | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 763747 | c.378G>A | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 763765 | c.396T>G | synonymous_variant | 0.97 | rifampicin | Not assoc w R - Interim |
| rpoC | 763792 | c.423G>A | synonymous_variant | 0.98 | rifampicin | |
| rpoC | 763807 | c.438T>C | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoC | 763813 | c.444C>G | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 763816 | c.447C>G | synonymous_variant | 0.95 | rifampicin | |
| rpoC | 763837 | c.468G>C | synonymous_variant | 0.87 | rifampicin | |
| rpoC | 763840 | c.471G>C | synonymous_variant | 0.89 | rifampicin | |
| rpoC | 763858 | c.489A>G | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 763861 | c.492C>T | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 763871 | p.Gly168Ser | missense_variant | 0.96 | rifampicin | |
| rpoC | 763876 | p.Glu169Asp | missense_variant | 0.96 | rifampicin | |
| rpoC | 763879 | c.510A>G | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 763891 | c.522G>C | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 763894 | c.525A>G | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 763900 | c.531G>C | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoC | 763921 | c.552G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763940 | p.Ala191Ser | missense_variant | 0.96 | rifampicin | Uncertain significance |
| rpoC | 763945 | c.576T>C | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 763947 | p.Ala193Val | missense_variant | 0.96 | rifampicin | Uncertain significance |
| rpoC | 763951 | c.582G>C | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoC | 763954 | c.585C>T | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 763960 | c.591T>G | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoC | 763963 | c.594C>T | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoC | 763978 | c.609C>T | synonymous_variant | 0.95 | rifampicin | |
| rpoC | 763987 | c.618C>T | synonymous_variant | 0.91 | rifampicin | |
| rpoC | 764131 | c.762T>C | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 764153 | p.Gln262Lys | missense_variant | 0.98 | rifampicin | |
| rpoC | 764161 | c.792G>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 764182 | p.Asp271Glu | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 764188 | c.819A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764195 | p.Ser276Asn | missense_variant | 0.99 | rifampicin | |
| rpoC | 764203 | c.834G>C | synonymous_variant | 0.97 | rifampicin | |
| rpoC | 764206 | p.Asp279Glu | missense_variant | 0.99 | rifampicin | |
| rpoC | 764207 | p.Val280Thr | missense_variant | 0.99 | rifampicin | Uncertain significance |
| rpoC | 764215 | c.846A>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 764217 | p.Asn283Ser | missense_variant | 0.99 | rifampicin | |
| rpoC | 764227 | c.858G>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 764239 | c.870T>G | synonymous_variant | 0.97 | rifampicin | Not assoc w R - Interim |
| rpoC | 764254 | c.885G>A | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 764263 | c.894G>C | synonymous_variant | 0.97 | rifampicin | |
| rpoC | 764266 | c.897T>C | synonymous_variant | 0.97 | rifampicin | |
| rpoC | 764272 | c.903G>C | synonymous_variant | 0.97 | rifampicin | |
| rpoC | 764278 | c.909A>G | synonymous_variant | 0.97 | rifampicin | Not assoc w R - Interim |
| rpoC | 764287 | c.918C>T | synonymous_variant | 0.97 | rifampicin | |
| rpoC | 764293 | c.924G>C | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoC | 764297 | p.Met310Leu | missense_variant | 0.96 | rifampicin | |
| rpoC | 764344 | c.975C>T | synonymous_variant | 0.94 | rifampicin | |
| rpoC | 764353 | c.984G>T | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
| rpoC | 764365 | c.996C>T | synonymous_variant | 0.97 | rifampicin | Not assoc w R - Interim |
| rpoC | 764371 | c.1002G>C | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
| rpoC | 764380 | c.1011G>C | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
| rpoC | 764387 | c.1018T>C | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoC | 764405 | c.1036_1038delAGGinsCC | frameshift_variant&missense_variant | 0.95 | rifampicin | |
| rpoC | 764431 | c.1062G>C | synonymous_variant | 0.88 | rifampicin | Not assoc w R - Interim |
| rpoC | 764434 | c.1065A>G | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
| rpoC | 764435 | c.1066_1068delAGGinsCA | frameshift_variant&missense_variant | 0.93 | rifampicin | |
| rpoC | 764440 | c.1071G>C | synonymous_variant | 0.93 | rifampicin | |
| rpoC | 764458 | c.1089G>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 764461 | c.1092A>G | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
| rpoC | 764968 | c.1599T>C | synonymous_variant | 0.98 | rifampicin | Not assoc w R - Interim |
| rpoC | 765007 | c.1638T>G | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765008 | c.1639T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765011 | c.1642_1644delAGCinsTCG | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 765016 | c.1647C>A | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765019 | c.1650A>G | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765034 | c.1665T>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 765040 | c.1671T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765041 | c.1672T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765047 | c.1678T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765055 | c.1686C>G | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765076 | c.1707A>G | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 765079 | c.1710T>G | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765082 | c.1713G>T | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 765083 | p.Arg572Lys | missense_variant | 0.99 | rifampicin | |
| rpoC | 765089 | c.1720T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 765103 | c.1734G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765121 | c.1752G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765757 | c.2388C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765772 | c.2403C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765778 | c.2409C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765779 | c.2410_2412delGACinsAG | frameshift_variant&missense_variant | 1.0 | rifampicin | |
| rpoC | 765784 | c.2415C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765793 | c.2424C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765796 | c.2427C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765800 | p.Phe811Leu | missense_variant | 1.0 | rifampicin | |
| rpoC | 765811 | c.2442T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765814 | c.2445A>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765817 | c.2448G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765826 | c.2457T>C | synonymous_variant | 0.97 | rifampicin | Not assoc w R - Interim |
| rpoC | 765836 | c.2467C>T | synonymous_variant | 0.97 | rifampicin | Not assoc w R - Interim |
| rpoC | 765871 | c.2502T>C | synonymous_variant | 0.97 | rifampicin | |
| rpoC | 765875 | p.Val836Ile | missense_variant | 0.97 | rifampicin | Uncertain significance |
| rpoC | 765886 | c.2517C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765904 | c.2535C>G | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoC | 765908 | c.2539C>T | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 765934 | c.2565C>T | synonymous_variant | 0.91 | rifampicin | |
| rpoC | 765937 | c.2568T>C | synonymous_variant | 0.95 | rifampicin | Not assoc w R - Interim |
| rpoC | 765940 | c.2571A>T | synonymous_variant | 0.91 | rifampicin | Not assoc w R - Interim |
| rpoC | 765946 | c.2577C>T | synonymous_variant | 0.91 | rifampicin | |
| rpoC | 765947 | c.2578T>C | synonymous_variant | 0.91 | rifampicin | Not assoc w R - Interim |
| rpoC | 765952 | c.2583G>C | synonymous_variant | 0.87 | rifampicin | |
| rpoC | 765962 | c.2593_2595delTTGinsCT | frameshift_variant&synonymous_variant | 0.91 | rifampicin | |
| rpoC | 765967 | c.2598C>T | synonymous_variant | 0.88 | rifampicin | Not assoc w R - Interim |
| rpoC | 765979 | c.2610C>G | synonymous_variant | 0.91 | rifampicin | Not assoc w R - Interim |
| rpoC | 765982 | c.2613C>T | synonymous_variant | 0.91 | rifampicin | Not assoc w R - Interim |
| rpoC | 765994 | c.2625A>T | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoC | 766012 | c.2643C>G | synonymous_variant | 0.95 | rifampicin | Not assoc w R - Interim |
| rpoC | 766021 | c.2652G>C | synonymous_variant | 0.95 | rifampicin | |
| rpoC | 766027 | c.2658G>T | synonymous_variant | 0.95 | rifampicin | |
| rpoC | 766034 | p.His889Asn | missense_variant | 0.95 | rifampicin | |
| rpoC | 766043 | p.Gln892Glu | missense_variant | 0.95 | rifampicin | |
| rpoC | 766067 | p.Glu900Thr | missense_variant | 0.96 | rifampicin | |
| rpoC | 766081 | c.2712T>C | synonymous_variant | 0.93 | rifampicin | |
| rpoC | 766084 | c.2715A>T | synonymous_variant | 0.93 | rifampicin | |
| rpoC | 766085 | c.2716_2718delCCCinsGG | frameshift_variant&missense_variant | 0.93 | rifampicin | |
| rpoC | 766093 | c.2724C>T | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
| rpoC | 766094 | p.Thr909Ser | missense_variant | 0.93 | rifampicin | |
| rpoC | 766109 | c.2740_2742delCCGinsGA | frameshift_variant&missense_variant | 0.96 | rifampicin | |
| rpoC | 766112 | p.Tyr915His | missense_variant | 0.96 | rifampicin | |
| rpoC | 766115 | p.Ile916Val | missense_variant | 0.92 | rifampicin | Uncertain significance |
| rpoC | 766120 | c.2751A>G | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 766129 | c.2760C>G | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 766131 | p.Tyr921Phe | missense_variant | 0.96 | rifampicin | |
| rpoC | 766135 | c.2766G>C | synonymous_variant | 0.96 | rifampicin | |
| rpoC | 766146 | p.Gly926Ala | missense_variant | 0.96 | rifampicin | |
| rpoC | 766153 | c.2784C>T | synonymous_variant | 0.96 | rifampicin | Not assoc w R - Interim |
| rpoC | 766651 | c.3282T>C | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 766658 | c.3289_3291delCGGinsGC | frameshift_variant&missense_variant | 0.92 | rifampicin | |
| rpoC | 766666 | c.3297C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766672 | c.3303T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766675 | c.3306C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766690 | c.3321G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766694 | c.3325_3327delCAGinsGC | frameshift_variant&missense_variant | 1.0 | rifampicin | |
| rpoC | 766714 | c.3345G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766720 | c.3351C>T | synonymous_variant | 0.94 | rifampicin | |
| rpoC | 766726 | c.3357T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766765 | c.3396A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| mmpL5 | 775736 | c.2745C>G | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775747 | p.Met912Leu | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775748 | c.2733T>A | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775754 | c.2727C>G | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775757 | c.2722_2724delACCinsTG | frameshift_variant&missense_variant | 0.86 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 775763 | c.2718T>G | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775774 | p.Met903Val | missense_variant | 0.87 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775779 | p.Thr901Ile | missense_variant | 0.87 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775783 | p.Leu900Met | missense_variant | 0.87 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775793 | p.Ala896Val | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775796 | c.2683_2685delTTTinsAG | frameshift_variant&stop_gained | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 775814 | c.2667C>G | synonymous_variant | 0.93 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775817 | c.2664T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 775832 | c.2649C>G | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775862 | c.2619G>C | synonymous_variant | 0.96 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775865 | c.2616T>G | synonymous_variant | 0.97 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775886 | c.2595A>T | synonymous_variant | 0.96 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775892 | p.His863Pro | missense_variant | 0.96 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775897 | p.Ile862Leu | missense_variant | 0.96 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775898 | c.2583G>A | synonymous_variant | 0.96 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775904 | c.2577G>A | synonymous_variant | 0.96 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775916 | c.2565T>G | synonymous_variant | 0.96 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775921 | c.2560C>T | synonymous_variant | 0.96 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775940 | c.2541C>T | synonymous_variant | 0.96 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 775955 | c.2524_2526delATCinsGG | frameshift_variant&missense_variant | 0.89 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 775961 | c.2520C>G | synonymous_variant | 0.83 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776018 | c.2463G>C | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776024 | c.2457G>C | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776030 | c.2451G>C | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776036 | c.2445G>C | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776039 | c.2442C>A | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776048 | c.2433G>C | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776053 | c.2428T>C | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776060 | c.2421C>G | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776075 | c.2406C>G | synonymous_variant | 0.94 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776081 | c.2400G>C | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776084 | c.2397C>G | synonymous_variant | 0.9 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776087 | c.2394C>G | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776096 | c.2385C>G | synonymous_variant | 0.95 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776100 | p.Thr794Leu | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776107 | c.2374C>T | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776129 | c.2352C>G | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776132 | c.2349A>G | synonymous_variant | 0.85 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776137 | p.Ser782Ala | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| rpsL | 781649 | c.90T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781655 | c.96T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781658 | c.99A>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781682 | c.123T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781709 | c.150G>C | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| rpsL | 781715 | c.156T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781718 | c.159C>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781728 | c.169T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781732 | c.174_177delGAGT | frameshift_variant | 1.0 | streptomycin | Uncertain significance |
| rpsL | 781739 | c.180_181insCGGC | frameshift_variant | 0.99 | streptomycin | Uncertain significance |
| rpsL | 781742 | c.183C>T | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781751 | c.192G>C | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781754 | c.195G>C | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781760 | c.201T>C | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781766 | c.207C>T | synonymous_variant | 0.99 | streptomycin | Not assoc w R - Interim |
| rpsL | 781772 | c.213C>T | synonymous_variant | 0.99 | streptomycin | Not assoc w R - Interim |
| rpsL | 781779 | c.220C>T | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781811 | c.252C>T | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781814 | c.255C>T | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781817 | c.258G>T | synonymous_variant | 0.98 | streptomycin | |
| rpsL | 781829 | c.270G>C | synonymous_variant | 0.98 | streptomycin | |
| rpsL | 781832 | c.273T>G | synonymous_variant | 0.95 | streptomycin | |
| rpsL | 781838 | c.279G>C | synonymous_variant | 0.97 | streptomycin | |
| rpsL | 781841 | c.282C>T | synonymous_variant | 0.92 | streptomycin | |
| rpsL | 781859 | c.300T>G | synonymous_variant | 0.95 | streptomycin | |
| rpsL | 781868 | c.309T>C | synonymous_variant | 0.96 | streptomycin | |
| rpsL | 781871 | c.312G>C | synonymous_variant | 0.97 | streptomycin | |
| rpsL | 781892 | c.333A>G | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781898 | c.339A>C | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781901 | c.342C>T | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781916 | c.357T>C | synonymous_variant | 0.99 | streptomycin | |
| rpsL | 781929 | p.Gly124Ser | missense_variant | 0.98 | streptomycin | Uncertain significance |
| rplC | 800516 | c.-293G>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800543 | c.-266C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800546 | c.-263T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800567 | c.-242A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800570 | c.-239C>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800574 | c.-235_-234delGTinsAC | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800579 | c.-230C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800591 | c.-218C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800594 | c.-215C>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800597 | c.-212A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800600 | c.-209G>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800603 | c.-206G>C | upstream_gene_variant | 0.95 | linezolid | |
| rplC | 800612 | c.-197A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800633 | c.-176T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800642 | c.-167C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800645 | c.-164C>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800648 | c.-161A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800654 | c.-155T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 801195 | c.387G>T | synonymous_variant | 1.0 | linezolid | |
| rplC | 801205 | p.Arg133Ala | missense_variant | 1.0 | linezolid | |
| rplC | 801220 | p.Ser138Ala | missense_variant | 1.0 | linezolid | |
| rplC | 801228 | c.420T>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 801252 | c.444G>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 801264 | c.456C>T | synonymous_variant | 1.0 | linezolid | |
| rplC | 801267 | c.459A>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 801270 | c.462T>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 801276 | c.468G>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 801281 | p.Ala158Gly | missense_variant | 1.0 | linezolid | |
| rplC | 801285 | c.477G>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 801307 | c.499_501delGCCinsTG | frameshift_variant&missense_variant | 1.0 | linezolid | |
| rplC | 801312 | c.504G>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 801315 | c.507G>T | synonymous_variant | 1.0 | linezolid | |
| rplC | 801324 | c.516T>C | synonymous_variant | 1.0 | linezolid | |
| fbiC | 1304515 | p.Ala529Thr | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304526 | c.1596T>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304532 | c.1602G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304541 | c.1611C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304544 | c.1614T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304546 | p.Val539Ala | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304559 | p.Glu543Asp | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304562 | c.1632G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304565 | c.1635C>A | synonymous_variant | 0.99 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304568 | c.1638T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304571 | c.1641G>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304580 | c.1650T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304613 | c.1683T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304628 | c.1698G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304634 | c.1704C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304637 | c.1707G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304640 | c.1710A>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304664 | c.1734G>A | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304670 | c.1740G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304671 | p.Val581Thr | missense_variant | 0.99 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304675 | p.Gly582Asp | missense_variant | 0.99 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304694 | c.1764A>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304715 | c.1785G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304727 | c.1797A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304742 | c.1812T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304748 | c.1818T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304751 | c.1821C>G | synonymous_variant | 0.98 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304757 | c.1827A>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304760 | c.1830G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304772 | c.1842C>T | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| fbiC | 1304784 | c.1854T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304787 | c.1857T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304790 | c.1860C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304808 | c.1878C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304811 | c.1881C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304817 | c.1887T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304826 | c.1896G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304829 | c.1899T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304830 | c.1900_1901delTCinsAG | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| sigE | 1364661 | c.249C>G | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364667 | c.255T>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364671 | c.259C>T | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364676 | c.264C>T | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364679 | c.267T>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364682 | c.270G>A | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364685 | c.273C>T | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364691 | c.279T>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364697 | c.285G>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364709 | c.297T>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364712 | c.300T>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364721 | c.309C>G | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364724 | c.312C>T | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364742 | c.330A>G | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364763 | c.351T>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364767 | c.355A>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364778 | c.366G>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364784 | c.372C>G | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364790 | c.378T>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364799 | c.387G>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364802 | c.390C>A | synonymous_variant | 0.99 | pyrazinamide | |
| sigE | 1364811 | c.399A>G | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364814 | c.402C>G | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364818 | c.406_408delCTAinsTG | frameshift_variant&stop_gained | 0.99 | pyrazinamide | Uncertain significance |
| sigE | 1364839 | c.427T>C | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364862 | c.450C>G | synonymous_variant | 0.98 | pyrazinamide | |
| sigE | 1364865 | c.453G>C | synonymous_variant | 0.99 | pyrazinamide | |
| sigE | 1364867 | p.Ala152Gly | missense_variant | 1.0 | pyrazinamide | |
| sigE | 1364877 | c.465G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| sigE | 1364883 | c.471G>A | synonymous_variant | 1.0 | pyrazinamide | |
| sigE | 1364887 | c.475_477delTTAinsCG | frameshift_variant&missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| sigE | 1364919 | p.Asp169Glu | missense_variant | 1.0 | pyrazinamide | |
| sigE | 1364922 | p.Glu170Asp | missense_variant | 1.0 | pyrazinamide | |
| sigE | 1364925 | c.513C>G | synonymous_variant | 1.0 | pyrazinamide | |
| atpE | 1461132 | p.Val30Ile | missense_variant | 0.82 | bedaquiline | |
| atpE | 1461137 | c.93C>G | synonymous_variant | 0.82 | bedaquiline | |
| atpE | 1461149 | c.105T>G | synonymous_variant | 0.77 | bedaquiline | |
| atpE | 1461155 | c.111C>G | synonymous_variant | 0.75 | bedaquiline | |
| atpE | 1461158 | c.114T>C | synonymous_variant | 0.85 | bedaquiline | |
| atpE | 1461159 | p.Val39Ile | missense_variant | 0.69 | bedaquiline | Uncertain significance |
| atpE | 1461167 | c.123G>T | synonymous_variant | 0.77 | bedaquiline | |
| atpE | 1461170 | c.126A>G | synonymous_variant | 0.85 | bedaquiline | |
| atpE | 1461179 | c.135G>C | synonymous_variant | 0.77 | bedaquiline | |
| atpE | 1461182 | c.138A>G | synonymous_variant | 0.77 | bedaquiline | |
| atpE | 1461185 | c.141G>C | synonymous_variant | 0.77 | bedaquiline | |
| atpE | 1461197 | c.153A>C | synonymous_variant | 0.77 | bedaquiline | |
| atpE | 1461219 | c.175T>C | synonymous_variant | 0.71 | bedaquiline | |
| atpE | 1461224 | c.180T>G | synonymous_variant | 0.69 | bedaquiline | |
| atpE | 1461230 | c.186G>C | synonymous_variant | 0.69 | bedaquiline | |
| atpE | 1461233 | c.189A>G | synonymous_variant | 0.69 | bedaquiline | |
| rrs | 1471532 | n.-314G>A | upstream_gene_variant | 0.99 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471539 | n.-307G>T | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471544 | n.-302T>C | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471550 | n.-296T>A | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471559 | n.-287C>T | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471565 | n.-281G>A | upstream_gene_variant | 0.92 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471569 | n.-277T>G | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1472847 | n.1002G>C | non_coding_transcript_exon_variant | 0.99 | streptomycin | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrs | 1472848 | n.1003T>G | non_coding_transcript_exon_variant | 0.99 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1472849 | n.1004C>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrs | 1472858 | n.1013G>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrs | 1472859 | n.1014G>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrs | 1472860 | n.1015C>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrs | 1472973 | n.1128A>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| inhA | 1673580 | c.-622T>C | upstream_gene_variant | 0.82 | ethionamide | |
| isoniazid | Uncertain significance | |||||
| inhA | 1673586 | c.-616C>G | upstream_gene_variant | 0.82 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673595 | c.-607A>C | upstream_gene_variant | 0.82 | ethionamide | |
| isoniazid | ||||||
| fabG1 | 1673596 | p.Lys53Glu | missense_variant | 0.82 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673607 | c.-595T>C | upstream_gene_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| fabG1 | 1673615 | p.Glu59Val | missense_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673619 | c.-583T>C | upstream_gene_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673625 | c.-577C>G | upstream_gene_variant | 0.88 | ethionamide | |
| isoniazid | ||||||
| fabG1 | 1673633 | p.Ser65Thr | missense_variant | 0.79 | ethionamide | |
| isoniazid | ||||||
| fabG1 | 1673636 | p.Asp66Ala | missense_variant | 0.83 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673643 | c.-559C>A | upstream_gene_variant | 0.83 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673646 | c.-556T>C | upstream_gene_variant | 0.83 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673649 | c.-553C>G | upstream_gene_variant | 0.83 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673652 | c.-550C>G | upstream_gene_variant | 0.83 | ethionamide | |
| isoniazid | ||||||
| fabG1 | 1673657 | p.Thr73Lys | missense_variant | 0.83 | ethionamide | |
| isoniazid | ||||||
| fabG1 | 1673660 | p.Ala74Glu | missense_variant | 0.83 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673664 | c.-538A>C | upstream_gene_variant | 0.83 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673676 | c.-526G>A | upstream_gene_variant | 0.92 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673679 | c.-523T>G | upstream_gene_variant | 0.92 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673691 | c.-511G>C | upstream_gene_variant | 0.92 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673703 | c.-499C>T | upstream_gene_variant | 0.9 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674468 | c.267C>T | synonymous_variant | 0.96 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| inhA | 1674471 | c.270G>C | synonymous_variant | 0.96 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674480 | c.279T>C | synonymous_variant | 0.96 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674486 | c.285T>C | synonymous_variant | 0.92 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674489 | c.288G>C | synonymous_variant | 0.92 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674503 | p.Thr101Ser | missense_variant | 0.92 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674507 | c.306G>T | synonymous_variant | 0.92 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674513 | c.312C>G | synonymous_variant | 0.92 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674514 | p.Ile105Val | missense_variant | 0.92 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674531 | c.330C>T | synonymous_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674534 | c.333G>T | synonymous_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674542 | p.Ala114Glu | missense_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674546 | c.345T>C | synonymous_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674549 | c.348G>C | synonymous_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674550 | p.Ser117Ala | missense_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674573 | c.372G>C | synonymous_variant | 0.98 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674582 | c.381T>C | synonymous_variant | 0.98 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674585 | c.384T>C | synonymous_variant | 0.98 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674589 | p.Met130Leu | missense_variant | 0.98 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674600 | c.399G>C | synonymous_variant | 0.97 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674610 | c.409_411delATCinsGG | frameshift_variant&missense_variant | 0.96 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674656 | p.Ser152Thr | missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674660 | c.459G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674690 | c.489C>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674702 | c.501G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674703 | c.502_504delTTGinsCC | frameshift_variant&missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674708 | c.507G>A | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674718 | c.517A>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674726 | c.525G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674732 | c.531C>T | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674738 | c.537C>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| inhA | 1674746 | p.Tyr182Phe | missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674756 | c.555T>G | synonymous_variant | 0.97 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674762 | c.561T>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674771 | c.570C>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674774 | c.573A>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674780 | c.579T>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674789 | c.588G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674795 | c.594G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674801 | c.600T>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674846 | p.Ile215Met | missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674855 | c.654C>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | Not assoc w R - Interim | |||||
| inhA | 1674858 | c.657G>A | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674879 | c.678T>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674904 | p.Ala235Pro | missense_variant | 0.97 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674924 | c.723G>C | synonymous_variant | 0.97 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674942 | c.741T>C | synonymous_variant | 0.96 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674954 | c.753G>C | synonymous_variant | 0.95 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674957 | c.756G>C | synonymous_variant | 0.94 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674963 | c.762G>C | synonymous_variant | 0.94 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674966 | c.765T>C | synonymous_variant | 0.94 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674967 | p.Asp256Thr | missense_variant | 0.94 | ethionamide | |
| isoniazid | ||||||
| rpsA | 1834096 | c.555G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834097 | c.556_557delTCinsAG | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834102 | c.561T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834150 | c.609G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834153 | c.612T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834154 | c.613_615delAACinsCG | frameshift_variant&missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1834157 | c.616T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834162 | c.621A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834165 | c.624A>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834169 | p.Thr210Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1834177 | c.636A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834189 | c.648G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834213 | c.672G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834234 | c.693G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834667 | p.Ala376Ser | missense_variant | 1.0 | pyrazinamide | |
| rpsA | 1834690 | c.1149T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834705 | c.1164C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834732 | c.1191T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834738 | c.1197A>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834753 | c.1212T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834759 | c.1218A>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834765 | p.Glu408Asp | missense_variant | 1.0 | pyrazinamide | |
| tsnR | 1853370 | c.-236_-234delGCAinsTG | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853375 | c.-231G>T | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853384 | c.-222G>C | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853387 | c.-219T>G | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853390 | c.-216G>C | upstream_gene_variant | 0.98 | linezolid | |
| tsnR | 1853394 | c.-212_-211delCTinsGC | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853417 | c.-189G>T | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853420 | c.-186T>G | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853429 | c.-177G>C | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853441 | c.-165C>T | upstream_gene_variant | 1.0 | linezolid | |
| katG | 2155632 | c.480A>C | synonymous_variant | 0.84 | isoniazid | |
| katG | 2155637 | p.Leu159Ile | missense_variant | 0.87 | isoniazid | |
| katG | 2155668 | c.444G>C | synonymous_variant | 0.92 | isoniazid | |
| katG | 2155674 | c.438G>C | synonymous_variant | 0.92 | isoniazid | |
| katG | 2155677 | c.435C>T | synonymous_variant | 0.92 | isoniazid | |
| katG | 2155680 | c.432G>C | synonymous_variant | 0.92 | isoniazid | |
| katG | 2155691 | c.421T>C | synonymous_variant | 0.93 | isoniazid | |
| katG | 2155696 | p.Ala139Val | missense_variant | 0.92 | isoniazid | |
| katG | 2155716 | c.396T>G | synonymous_variant | 0.92 | isoniazid | |
| katG | 2155722 | c.390G>C | synonymous_variant | 0.92 | isoniazid | |
| katG | 2155728 | c.384G>C | synonymous_variant | 0.92 | isoniazid | |
| katG | 2155742 | p.Gly124Arg | missense_variant | 0.92 | isoniazid | |
| katG | 2155747 | p.Ala122Gly | missense_variant | 0.96 | isoniazid | |
| katG | 2155764 | p.His116Gln | missense_variant | 0.97 | isoniazid | |
| katG | 2155770 | c.342C>G | synonymous_variant | 0.97 | isoniazid | |
| katG | 2155785 | c.327T>C | synonymous_variant | 0.96 | isoniazid | |
| katG | 2155788 | c.324C>T | synonymous_variant | 0.95 | isoniazid | |
| katG | 2155796 | p.Ala106Ser | missense_variant | 0.94 | isoniazid | |
| katG | 2155805 | p.Ile103Val | missense_variant | 0.93 | isoniazid | Uncertain significance |
| katG | 2155806 | c.306T>C | synonymous_variant | 0.93 | isoniazid | |
| katG | 2155815 | c.297G>C | synonymous_variant | 0.92 | isoniazid | |
| katG | 2155824 | c.288C>T | synonymous_variant | 0.92 | isoniazid | Not assoc w R - Interim |
| katG | 2155828 | p.Tyr95Phe | missense_variant | 0.9 | isoniazid | |
| kasA | 2518756 | c.642G>C | synonymous_variant | 0.98 | isoniazid | |
| kasA | 2518780 | p.Glu222Asp | missense_variant | 0.98 | isoniazid | |
| kasA | 2518783 | c.669T>C | synonymous_variant | 0.95 | isoniazid | |
| kasA | 2518785 | p.Glu224Ala | missense_variant | 0.95 | isoniazid | |
| kasA | 2518787 | c.673_675delCGGinsGC | frameshift_variant&missense_variant | 0.93 | isoniazid | |
| kasA | 2518792 | c.678C>G | synonymous_variant | 0.95 | isoniazid | |
| kasA | 2518795 | c.681C>T | synonymous_variant | 0.95 | isoniazid | |
| kasA | 2518813 | c.699C>T | synonymous_variant | 0.95 | isoniazid | |
| kasA | 2518816 | c.702C>T | synonymous_variant | 0.95 | isoniazid | |
| kasA | 2518822 | c.708C>A | synonymous_variant | 0.95 | isoniazid | |
| kasA | 2518825 | c.711T>C | synonymous_variant | 0.95 | isoniazid | |
| kasA | 2518843 | c.729T>C | synonymous_variant | 0.95 | isoniazid | |
| kasA | 2518847 | p.Leu245Met | missense_variant | 0.95 | isoniazid | |
| kasA | 2518853 | p.Leu247Ile | missense_variant | 0.92 | isoniazid | |
| kasA | 2518864 | c.750G>C | synonymous_variant | 0.95 | isoniazid | |
| kasA | 2518873 | c.759C>T | synonymous_variant | 0.91 | isoniazid | |
| kasA | 2518877 | p.Lys255Leu | missense_variant | 0.88 | isoniazid | |
| ahpC | 2726567 | c.375C>G | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726585 | c.393C>T | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726593 | p.Val134Ala | missense_variant | 1.0 | isoniazid | |
| ahpC | 2726600 | c.408T>C | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726633 | c.441C>G | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726638 | p.Ala149Val | missense_variant | 1.0 | isoniazid | |
| ahpC | 2726645 | c.453C>G | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726648 | c.456T>C | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726657 | c.465A>G | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726669 | c.477T>C | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726675 | c.483A>G | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726681 | c.489A>G | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726690 | c.498C>T | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726696 | c.504C>G | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726702 | c.510C>T | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726717 | c.525A>C | synonymous_variant | 1.0 | isoniazid | |
| ahpC | 2726727 | p.Arg179Lys | missense_variant | 1.0 | isoniazid | |
| Rv2477c | 2783332 | c.711T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783335 | c.708C>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783344 | c.699C>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783350 | c.693T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783353 | c.690T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783359 | c.684G>A | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783374 | c.669G>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783386 | c.657G>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783395 | c.648T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783419 | c.624G>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783422 | c.621T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783425 | p.Pro206Lys | missense_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783440 | c.603T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| thyX | 3067340 | c.606G>A | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067351 | c.595C>A | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067355 | c.591A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067373 | c.573C>G | synonymous_variant | 0.97 | para-aminosalicylic_acid | |
| thyX | 3067376 | c.570G>C | synonymous_variant | 0.97 | para-aminosalicylic_acid | |
| thyX | 3067385 | c.561C>G | synonymous_variant | 0.97 | para-aminosalicylic_acid | |
| thyX | 3067391 | c.555G>T | synonymous_variant | 0.97 | para-aminosalicylic_acid | |
| thyX | 3067415 | c.531C>T | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067418 | c.528C>A | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067430 | c.516C>G | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067439 | c.507A>G | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067442 | c.504C>A | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067457 | c.489C>T | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067463 | c.481_483delATCinsGT | frameshift_variant&missense_variant | 0.96 | para-aminosalicylic_acid | |
| thyX | 3067475 | c.471A>G | synonymous_variant | 0.97 | para-aminosalicylic_acid | |
| thyX | 3067493 | c.453A>G | synonymous_variant | 0.95 | para-aminosalicylic_acid | |
| thyX | 3067499 | p.Lys149Arg | missense_variant | 0.92 | para-aminosalicylic_acid | |
| thyX | 3067502 | c.444C>G | synonymous_variant | 0.84 | para-aminosalicylic_acid | |
| thyX | 3067508 | c.438G>C | synonymous_variant | 0.84 | para-aminosalicylic_acid | |
| thyX | 3067511 | c.435G>A | synonymous_variant | 0.84 | para-aminosalicylic_acid | |
| thyX | 3067515 | p.Ser144Thr | missense_variant | 0.94 | para-aminosalicylic_acid | |
| thyX | 3067530 | p.Ala139Ser | missense_variant | 0.93 | para-aminosalicylic_acid | |
| thyX | 3067619 | c.327A>G | synonymous_variant | 0.89 | para-aminosalicylic_acid | |
| thyX | 3067631 | c.315C>G | synonymous_variant | 0.92 | para-aminosalicylic_acid | |
| thyX | 3067646 | c.300C>G | synonymous_variant | 0.9 | para-aminosalicylic_acid | |
| thyX | 3067652 | c.294T>C | synonymous_variant | 0.95 | para-aminosalicylic_acid | |
| thyX | 3067658 | c.288C>T | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067661 | c.285C>G | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067676 | c.270C>G | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067680 | p.Cys89Ala | missense_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067688 | c.258G>C | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067694 | c.252G>T | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067709 | c.235_237delTCGinsAC | frameshift_variant&missense_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067712 | c.234G>C | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067718 | c.228C>G | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067721 | c.225T>C | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067727 | c.219A>G | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067730 | c.216G>C | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067760 | c.186G>T | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067765 | p.Leu61Ile | missense_variant | 0.97 | para-aminosalicylic_acid | |
| thyX | 3067771 | p.Gly59Ser | missense_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067772 | c.174C>G | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067781 | c.165C>G | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067784 | c.162C>G | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyX | 3067787 | p.Lys53Arg | missense_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067802 | c.144C>G | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067817 | c.129C>T | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067839 | p.Val36Thr | missense_variant | 0.92 | para-aminosalicylic_acid | |
| thyX | 3067841 | c.105G>C | synonymous_variant | 0.9 | para-aminosalicylic_acid | |
| thyX | 3067844 | c.102G>A | synonymous_variant | 0.9 | para-aminosalicylic_acid | |
| thyX | 3067847 | c.99C>T | synonymous_variant | 0.87 | para-aminosalicylic_acid | |
| thyX | 3067853 | c.93C>T | synonymous_variant | 0.9 | para-aminosalicylic_acid | |
| thyX | 3067862 | c.84C>T | synonymous_variant | 0.9 | para-aminosalicylic_acid | |
| thyX | 3067869 | p.Thr26Ser | missense_variant | 0.9 | para-aminosalicylic_acid | |
| thyX | 3067874 | c.72C>A | synonymous_variant | 0.9 | para-aminosalicylic_acid | |
| mtrB | 3625222 | c.1392T>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| lpqB | 3625243 | c.-333T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625246 | c.-336G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625251 | c.-341C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625252 | c.-342G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625255 | c.-345T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625258 | c.-348G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625267 | c.1347T>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| lpqB | 3625270 | c.-360G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625282 | c.-372C>G | upstream_gene_variant | 0.99 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625285 | c.-375G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625291 | c.-381A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625301 | p.Ala438Gly | missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625312 | c.-402G>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625318 | c.-408G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625325 | p.His430Arg | missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625345 | c.-435T>C | upstream_gene_variant | 0.99 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625351 | c.1263T>C | synonymous_variant | 0.99 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| lpqB | 3625354 | c.-444G>C | upstream_gene_variant | 0.99 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625357 | c.-447T>C | upstream_gene_variant | 0.99 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625372 | c.-462A>G | upstream_gene_variant | 0.97 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625375 | c.-465A>G | upstream_gene_variant | 0.97 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625384 | c.1228_1230delGCGinsCC | frameshift_variant&synonymous_variant | 0.94 | bedaquiline | Uncertain significance |
| rifampicin | Uncertain significance | |||||
| lpqB | 3625390 | c.-480C>G | upstream_gene_variant | 0.94 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625396 | c.-486G>C | upstream_gene_variant | 0.94 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625407 | p.Gln403Glu | missense_variant | 0.91 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625408 | p.Glu402Asp | missense_variant | 0.9 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625669 | c.-759G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625672 | c.-762G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625683 | c.-773C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625687 | c.-777G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625690 | c.-780T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625702 | c.-792C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625711 | c.903C>T | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| lpqB | 3625714 | c.-804C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625720 | c.894G>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3625729 | c.885A>G | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| lpqB | 3625735 | c.-825C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625741 | c.-831G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625744 | c.870G>A | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3625747 | c.867G>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3625753 | p.Ala287Gln | missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625756 | c.-846C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| lpqB | 3625762 | c.-852A>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625765 | c.849C>G | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| lpqB | 3625770 | c.-860C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3625774 | c.840G>A | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3625806 | c.808A>C | synonymous_variant | 0.95 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3626684 | c.-71G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626704 | c.-91C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626711 | p.Thr213Gln | missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626723 | c.-110C>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626726 | c.-113T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626732 | c.-119A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626749 | c.601C>T | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3626750 | c.-137T>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626773 | c.-160C>T | upstream_gene_variant | 0.99 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626774 | c.574_576delAGGinsCT | frameshift_variant&missense_variant | 0.98 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626780 | c.-167T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626783 | c.-170C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626786 | c.-173A>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626792 | c.-179G>C | upstream_gene_variant | 0.99 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626795 | c.-182C>T | upstream_gene_variant | 0.99 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626798 | c.-185T>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626804 | c.546A>G | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3626846 | c.504G>A | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3626852 | c.-239G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626857 | c.-244T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626858 | c.-245A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626861 | c.-248C>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626864 | c.484_486delTTGinsCC | frameshift_variant&missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626876 | c.-263A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626890 | c.-277T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626894 | c.-281C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626906 | c.442_444delAACinsCG | frameshift_variant&missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626912 | c.438T>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3626915 | c.-302C>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626924 | c.-311G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626930 | c.-317A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626933 | c.-320C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626939 | c.411A>G | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3626942 | c.-329A>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626949 | p.Ala134Asn | missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626954 | c.-341C>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626962 | p.Met130Leu | missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3626969 | c.381C>T | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3626978 | p.Asp124Glu | missense_variant | 1.0 | bedaquiline | |
| rifampicin | Uncertain significance | |||||
| mtrB | 3626996 | c.-383G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3626999 | c.-386G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627005 | c.-392G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627008 | c.-395G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627011 | c.-398T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627023 | c.-410C>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627158 | c.-545C>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627203 | c.-590C>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627209 | c.-596G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627212 | c.-599C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627215 | c.135G>A | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3627224 | c.-611G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627227 | c.-614T>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627233 | p.Thr39Ser | missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627236 | c.-623T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627239 | c.111C>T | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3627247 | p.Ile35Val | missense_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627251 | c.-638G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627263 | c.-650C>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627269 | c.81G>T | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3627272 | c.-659G>T | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627277 | c.73C>T | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3627278 | c.-665G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrB | 3627301 | c.-688T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| fbiB | 3642602 | c.1068A>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642605 | c.1071A>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642620 | c.1086T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642623 | c.1089C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642632 | c.1098C>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642656 | c.1122G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642665 | c.1131C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642668 | c.1134A>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642671 | c.1137G>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642674 | c.1140C>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642680 | c.1146A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642683 | c.1149C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642684 | c.1150T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642692 | c.1158C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642704 | c.1170G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642709 | p.Gly392Glu | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642711 | p.Leu393Val | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642719 | c.1185T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| rpoA | 3877803 | c.705G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877815 | c.693C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877818 | c.690A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877848 | c.660C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877856 | c.652T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877857 | c.651G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877866 | c.642G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877875 | c.633T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877887 | c.621G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877893 | c.615C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877905 | c.603A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877908 | c.600T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877920 | c.588G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877923 | c.585C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877926 | c.582G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877962 | c.546G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877968 | c.540C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877971 | p.Asp179Glu | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3877974 | c.534G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877989 | c.519A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877992 | c.516C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878001 | c.505_507delTCAinsAGC | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878016 | c.492C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878019 | c.489A>G | synonymous_variant | 1.0 | rifampicin | |
| clpC1 | 4038359 | c.2346A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038368 | c.2337T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038383 | c.2322G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038388 | c.2317T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038392 | c.2313C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038398 | c.2307G>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038401 | c.2302_2304delTTGinsCC | frameshift_variant&missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038407 | c.2298G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038419 | c.2286T>A | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038434 | c.2271G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038444 | p.Ala754Lys | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038446 | c.2259T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038456 | p.Val750Glu | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038460 | p.Leu749Met | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038461 | c.2244G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038474 | p.Ser744Thr | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038486 | p.Gly740Asn | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038489 | p.Ala739Gly | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038519 | p.Arg729Gln | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038530 | p.Glu725Asp | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038533 | p.Arg724Gln | missense_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038536 | c.2169C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038551 | c.2154C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038563 | c.2142C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038587 | c.2118C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038596 | c.2109A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038602 | c.2103G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038623 | c.2082A>G | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038640 | p.Asp689Asn | missense_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038647 | c.2058T>G | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038658 | p.Lys683Gln | missense_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038660 | c.2044_2045delTCinsAG | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038662 | c.2043T>C | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038671 | c.2034T>A | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038677 | c.2026_2028delCCGinsGT | frameshift_variant&missense_variant | 0.98 | pyrazinamide | |
| clpC1 | 4038683 | c.2020_2022delTCTinsAGC | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038698 | c.2007C>T | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038704 | c.2001T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038710 | c.1995G>C | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038713 | c.1992T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038725 | c.1980C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038755 | c.1950G>C | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4038767 | c.1938G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039067 | c.1638G>C | synonymous_variant | 0.75 | pyrazinamide | |
| clpC1 | 4039079 | c.1626C>G | synonymous_variant | 0.9 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039085 | c.1620A>G | synonymous_variant | 0.9 | pyrazinamide | |
| clpC1 | 4039091 | c.1614G>C | synonymous_variant | 0.9 | pyrazinamide | |
| clpC1 | 4039097 | c.1608G>T | synonymous_variant | 0.9 | pyrazinamide | |
| clpC1 | 4039100 | c.1605C>T | synonymous_variant | 0.87 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039103 | c.1602T>C | synonymous_variant | 0.87 | pyrazinamide | |
| clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.88 | pyrazinamide | |
| clpC1 | 4039118 | c.1587C>A | synonymous_variant | 0.93 | pyrazinamide | |
| clpC1 | 4039124 | c.1581C>A | synonymous_variant | 0.93 | pyrazinamide | |
| clpC1 | 4039127 | p.Lys526Arg | missense_variant | 0.93 | pyrazinamide | |
| clpC1 | 4039136 | c.1569C>T | synonymous_variant | 0.95 | pyrazinamide | |
| clpC1 | 4039139 | c.1566G>A | synonymous_variant | 0.96 | pyrazinamide | |
| clpC1 | 4039145 | c.1560G>A | synonymous_variant | 0.97 | pyrazinamide | |
| clpC1 | 4039169 | c.1536A>G | synonymous_variant | 0.98 | pyrazinamide | |
| clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.98 | pyrazinamide | |
| clpC1 | 4039183 | c.1522T>C | synonymous_variant | 0.98 | pyrazinamide | |
| clpC1 | 4039187 | c.1518G>T | synonymous_variant | 0.98 | pyrazinamide | |
| clpC1 | 4039190 | c.1515C>G | synonymous_variant | 0.98 | pyrazinamide | |
| clpC1 | 4039208 | c.1497C>G | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4039226 | c.1479T>C | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039241 | c.1464G>C | synonymous_variant | 0.98 | pyrazinamide | |
| clpC1 | 4039271 | c.1434G>A | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039274 | c.1431G>A | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039280 | c.1425G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039286 | c.1419T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039292 | c.1413C>T | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4039295 | c.1410A>C | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4039310 | c.1395A>G | synonymous_variant | 0.98 | pyrazinamide | |
| clpC1 | 4039313 | c.1392C>G | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4039319 | c.1386T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039322 | c.1383T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039328 | c.1377A>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039336 | c.1369C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039337 | p.Thr456Gln | missense_variant | 0.99 | pyrazinamide | |
| clpC1 | 4039346 | c.1359G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039352 | c.1353C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039382 | c.1323C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039391 | c.1314T>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039394 | c.1311G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039397 | c.1308A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039409 | c.1296T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039412 | c.1293T>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039415 | p.Glu430Asp | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| clpC1 | 4039430 | c.1275T>C | synonymous_variant | 0.97 | pyrazinamide | |
| clpC1 | 4039442 | c.1263A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039865 | c.840T>C | synonymous_variant | 0.98 | pyrazinamide | |
| clpC1 | 4039868 | c.837C>T | synonymous_variant | 0.98 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4039904 | c.801A>G | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4039913 | c.792C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039931 | c.774T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039934 | c.771G>A | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039937 | c.768G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039946 | c.759A>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039951 | c.754C>T | synonymous_variant | 0.99 | pyrazinamide | |
| clpC1 | 4039952 | c.753T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039958 | c.747G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039991 | c.714G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040018 | c.687G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040021 | c.684A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040024 | c.681A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040033 | c.672G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040057 | c.648C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040522 | c.183T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040543 | c.162C>T | synonymous_variant | 0.96 | pyrazinamide | |
| clpC1 | 4040546 | c.159G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040561 | c.144A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040567 | c.138C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040570 | c.135C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040573 | c.132T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040582 | c.123G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040585 | c.120A>G | synonymous_variant | 0.93 | pyrazinamide | |
| clpC1 | 4040588 | c.117T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040591 | c.114C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040597 | c.108C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040600 | c.105A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040603 | c.102T>G | synonymous_variant | 1.0 | pyrazinamide | |
| glpK | 4138658 | c.1098C>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138661 | c.1095T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138670 | c.1086G>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138676 | c.1080T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138679 | c.1075_1077delATGinsGC | frameshift_variant&missense_variant | 1.0 | ethambutol | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| glpK | 4138696 | p.Pro354Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| streptomycin | ||||||
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| glpK | 4138697 | c.1059C>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138703 | c.1053C>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138718 | c.1038T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138724 | c.1032A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138727 | c.1029C>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138730 | c.1026C>T | synonymous_variant | 0.99 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138775 | c.981C>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138787 | c.969C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | ||||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4138796 | c.960A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138805 | c.951C>T | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138808 | c.948G>T | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138817 | c.939T>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138822 | p.Asn312Asp | missense_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138829 | c.927A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138832 | c.924C>T | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138838 | c.918G>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138847 | c.909A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138853 | c.903C>A | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| embC | 4240717 | c.855T>C | synonymous_variant | 0.98 | ethambutol | |
| embC | 4240726 | c.864G>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4240747 | c.885C>T | synonymous_variant | 0.99 | ethambutol | Not assoc w R - Interim |
| embC | 4240756 | c.894G>C | synonymous_variant | 0.99 | ethambutol | |
| embC | 4240780 | c.918T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240783 | c.921G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240822 | c.960C>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240825 | c.963G>A | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240828 | c.966G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240831 | c.969T>G | synonymous_variant | 0.99 | ethambutol | |
| embC | 4240837 | c.975C>T | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240858 | c.996G>C | synonymous_variant | 0.99 | ethambutol | |
| embC | 4240867 | c.1005T>C | synonymous_variant | 0.99 | ethambutol | |
| embC | 4240870 | c.1008T>C | synonymous_variant | 0.98 | ethambutol | |
| embC | 4240874 | c.1012_1013delAGinsTC | synonymous_variant | 0.99 | ethambutol | |
| embC | 4240879 | c.1017G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240892 | p.Met344Leu | missense_variant | 1.0 | ethambutol | |
| embC | 4240897 | c.1035C>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4240900 | c.1038A>T | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240911 | p.Ala350Val | missense_variant | 1.0 | ethambutol | |
| embC | 4240922 | c.1060_1062delACCinsGG | frameshift_variant&missense_variant | 1.0 | ethambutol | |
| embC | 4241039 | p.Asp393Asn | missense_variant | 0.96 | ethambutol | |
| embC | 4241047 | c.1185C>A | synonymous_variant | 0.92 | ethambutol | |
| embC | 4241050 | c.1188T>G | synonymous_variant | 0.96 | ethambutol | |
| embC | 4241053 | c.1191G>T | synonymous_variant | 0.96 | ethambutol | |
| embC | 4241074 | c.1212G>C | synonymous_variant | 0.96 | ethambutol | |
| embC | 4241095 | c.1233C>T | synonymous_variant | 0.95 | ethambutol | |
| embC | 4241107 | c.1245G>C | synonymous_variant | 0.95 | ethambutol | |
| embC | 4241109 | p.Ala416Gly | missense_variant | 0.95 | ethambutol | |
| embC | 4241113 | c.1251G>A | synonymous_variant | 0.95 | ethambutol | Not assoc w R - Interim |
| embC | 4241121 | p.Ser420Asn | missense_variant | 0.91 | ethambutol | |
| embC | 4241125 | c.1263G>C | synonymous_variant | 0.91 | ethambutol | |
| embC | 4241126 | p.Leu422Met | missense_variant | 0.91 | ethambutol | |
| embC | 4241129 | c.1267C>T | synonymous_variant | 0.91 | ethambutol | |
| embC | 4241140 | c.1278A>C | synonymous_variant | 0.91 | ethambutol | |
| embC | 4241147 | p.Cys429Ile | missense_variant | 0.91 | ethambutol | |
| embC | 4241158 | c.1296T>C | synonymous_variant | 0.91 | ethambutol | |
| embC | 4241162 | c.1300T>C | synonymous_variant | 0.91 | ethambutol | |
| embC | 4241168 | c.1306C>T | synonymous_variant | 0.91 | ethambutol | Not assoc w R - Interim |
| embB | 4247434 | c.921C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247464 | c.951C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247470 | c.957T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247491 | c.978G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247494 | c.981G>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247497 | c.984T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247512 | c.999T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247527 | c.1014G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247540 | p.Val343Ile | missense_variant | 1.0 | ethambutol | |
| embB | 4247554 | c.1041T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247555 | c.1042_1044delCTGinsAC | frameshift_variant&missense_variant | 1.0 | ethambutol | |
| embB | 4247566 | c.1053C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247572 | c.1059A>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247957 | p.Met482Leu | missense_variant | 1.0 | ethambutol | |
| embB | 4247974 | c.1461C>A | synonymous_variant | 0.91 | ethambutol | |
| embB | 4247977 | c.1464C>G | synonymous_variant | 0.92 | ethambutol | |
| embB | 4248007 | c.1494C>T | synonymous_variant | 0.93 | ethambutol | |
| embB | 4248008 | c.1495_1497delCTGinsTC | frameshift_variant&missense_variant | 0.93 | ethambutol | |
| embB | 4248011 | p.Ser500Ala | missense_variant | 0.93 | ethambutol | |
| embB | 4248034 | c.1521G>A | synonymous_variant | 0.93 | ethambutol | |
| embB | 4248035 | p.Val508Ile | missense_variant | 0.93 | ethambutol | |
| embB | 4248041 | p.Ala510Thr | missense_variant | 0.93 | ethambutol | Uncertain significance |
| embB | 4248044 | p.Lys511Ala | missense_variant | 0.93 | ethambutol | |
| embB | 4248052 | c.1539G>C | synonymous_variant | 0.93 | ethambutol | Not assoc w R - Interim |
| embB | 4248056 | p.Ser515Ala | missense_variant | 0.93 | ethambutol | |
| embB | 4248063 | p.Ala517Glu | missense_variant | 0.93 | ethambutol | |
| embB | 4248070 | c.1557T>C | synonymous_variant | 0.93 | ethambutol | |
| embB | 4248085 | c.1572T>C | synonymous_variant | 0.95 | ethambutol | |
| embB | 4248097 | c.1584C>G | synonymous_variant | 0.94 | ethambutol | |
| embB | 4248106 | c.1593C>G | synonymous_variant | 0.92 | ethambutol | |
| embB | 4248109 | c.1596C>T | synonymous_variant | 0.91 | ethambutol | Not assoc w R - Interim |
| embB | 4248112 | c.1599C>G | synonymous_variant | 0.91 | ethambutol | |
| embB | 4248118 | c.1605T>C | synonymous_variant | 0.9 | ethambutol | |
| embB | 4248127 | c.1614G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248130 | c.1617G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248133 | c.1620C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248139 | c.1626C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248142 | c.1629T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248143 | c.1630_1632delTTGinsAC | frameshift_variant&missense_variant | 1.0 | ethambutol | |
| embB | 4248157 | c.1644A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248158 | p.Cys549Ser | missense_variant | 1.0 | ethambutol | |
| embB | 4248167 | p.Thr552Ala | missense_variant | 1.0 | ethambutol | |
| embB | 4248170 | p.Ala553Ser | missense_variant | 1.0 | ethambutol | |
| embB | 4248173 | p.Val554Leu | missense_variant | 1.0 | ethambutol | |
| embB | 4248196 | c.1683G>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248199 | c.1686A>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248200 | p.Ile563Val | missense_variant | 1.0 | ethambutol | |
| embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248217 | c.1704C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248225 | p.Ala571Val | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248242 | p.Val577Ile | missense_variant | 1.0 | ethambutol | |
| embB | 4248252 | p.Gly580Ala | missense_variant | 1.0 | ethambutol | |
| embB | 4248256 | c.1743C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248259 | p.Met582Ile | missense_variant | 1.0 | ethambutol | |
| embB | 4248269 | p.Met586Gln | missense_variant | 1.0 | ethambutol | |
| embB | 4248275 | c.1762_1764delACGinsGA | frameshift_variant&missense_variant | 1.0 | ethambutol | |
| embB | 4248304 | c.1791G>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248319 | c.1806A>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248322 | c.1809G>T | synonymous_variant | 1.0 | ethambutol |
