TB-Profiler result

Run: SRR1049725
Summary

Run ID: SRR1049725

Sample name:

Date: 2024-03-26T19:04:20.415131

Number of reads: 777614

Percentage reads mapped: 11.95

Median coverage: 15.0

Strain: lineage4.1.2.1;lineage4.4.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.65
lineage4.1.2 Euro-American None 0.84
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.86
lineage4.4.1 Euro-American (S-type) None 0.06
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpsL 781822 p.Lys88Arg missense_variant 0.27 streptomycin Assoc w R
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.83 amikacin Assoc w R
kanamycin Assoc w R
capreomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.7 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 0.83 ethionamide Uncertain significance
rpoB 760115 c.309C>T synonymous_variant 0.76 rifampicin Not assoc w R
rpoB 761084 c.1278C>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.32 rifampicin
rpoB 761207 c.1401C>A synonymous_variant 0.44 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.52 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761980 p.Tyr725Phe missense_variant 0.38 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.46 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.46 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.46 rifampicin
rpoB 762015 c.2209_2211delGAAinsCG frameshift_variant&missense_variant 0.46 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.52 rifampicin
rpoB 762026 c.2220G>C synonymous_variant 0.53 rifampicin
rpoB 762030 p.Thr742Ser missense_variant 0.55 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.44 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.43 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>T synonymous_variant 0.65 rifampicin
rpoB 762251 c.2445G>C synonymous_variant 0.63 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.66 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.68 rifampicin
rpoB 762273 p.Ala823Ser missense_variant 0.65 rifampicin
rpoB 762278 c.2472C>T synonymous_variant 0.58 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762855 p.Val1017Ile missense_variant 0.5 rifampicin
rpoB 762858 c.3052_3054delACGinsTC frameshift_variant&missense_variant 0.53 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 762866 c.-504C>A upstream_gene_variant 0.37 rifampicin
rpoB 762878 p.Ile1024Met missense_variant 0.59 rifampicin
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.59 rifampicin
rpoB 762887 c.3081G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 762896 c.-474G>C upstream_gene_variant 0.55 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 762980 c.-390T>C upstream_gene_variant 0.6 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.58 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.76 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763100 c.-270G>A upstream_gene_variant 0.52 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.53 rifampicin
rpoB 763122 c.3316_3318delATCinsCG frameshift_variant&missense_variant 0.52 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763136 c.-234C>A upstream_gene_variant 0.53 rifampicin
rpoC 763157 c.-213G>C upstream_gene_variant 0.46 rifampicin
rpoC 763160 c.-210G>C upstream_gene_variant 0.39 rifampicin
rpoB 763161 p.Leu1119Ile missense_variant 0.39 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.38 rifampicin
rpoB 763170 p.Leu1122Met missense_variant 0.38 rifampicin
rpoC 763483 c.114G>C synonymous_variant 0.54 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.47 rifampicin
rpoC 763504 c.135C>A synonymous_variant 0.64 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.62 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.63 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.7 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.69 rifampicin
rpoC 763537 c.168C>T synonymous_variant 0.69 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Ala missense_variant 0.69 rifampicin
rpoC 763558 c.189C>A synonymous_variant 0.31 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763585 c.216C>G synonymous_variant 0.4 rifampicin
rpoC 763597 c.228G>A synonymous_variant 0.27 rifampicin
rpoC 763621 c.252C>T synonymous_variant 0.79 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.83 rifampicin
rpoC 763672 c.303C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.77 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.77 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.77 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.77 rifampicin
rpoC 763726 c.357C>T synonymous_variant 0.67 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.69 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.69 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.63 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.56 rifampicin
rpoC 764491 c.1122G>C synonymous_variant 0.47 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.45 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.52 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.52 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.32 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 0.59 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>G synonymous_variant 0.75 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 0.77 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.31 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.38 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.77 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.77 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.37 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764641 c.1272C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764679 p.Lys437Ser missense_variant 0.38 rifampicin
rpoC 764683 c.1314G>C synonymous_variant 0.4 rifampicin
rpoC 764690 p.Cys441Ala missense_variant 0.4 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764705 p.Leu446Thr missense_variant 0.47 rifampicin
rpoC 764713 c.1344G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764737 c.1368G>C synonymous_variant 0.26 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.6 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.57 rifampicin
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.53 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.59 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764808 p.Arg480His missense_variant 0.61 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.57 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764843 p.Ala492Thr missense_variant 0.42 rifampicin
rpoC 764858 c.1489_1491delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.27 rifampicin
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.36 rifampicin
rpoC 764956 c.1587T>C synonymous_variant 0.38 rifampicin
rpoC 764957 p.Glu530Ser missense_variant 0.4 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764998 c.1629G>C synonymous_variant 0.45 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765014 p.Ala549Pro missense_variant 0.43 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.82 rifampicin Not assoc w R
rpsL 781760 c.201T>C synonymous_variant 0.35 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.41 streptomycin
rpsL 781796 p.Met79Ile missense_variant 0.43 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.4 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.26 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.42 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.42 streptomycin
rpsL 781829 c.270G>T synonymous_variant 0.3 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.41 streptomycin
rplC 800633 c.-176T>C upstream_gene_variant 0.38 linezolid
rplC 800645 c.-164C>T upstream_gene_variant 0.48 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.48 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.48 linezolid
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.57 linezolid
rplC 800672 c.-137G>T upstream_gene_variant 0.55 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.46 linezolid
rplC 800702 c.-107G>T upstream_gene_variant 0.38 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.38 linezolid
sigE 1365174 c.762C>T synonymous_variant 0.79 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471967 n.122G>A non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471980 n.135G>T non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1471981 n.136C>G non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471997 n.152T>C non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>C non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472027 n.182C>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>C non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472043 n.198T>G non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472067 n.222G>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472068 n.223T>G non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472092 n.247C>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472120 n.275G>A non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472223 n.378C>G non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472228 n.383G>C non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472245 n.400C>A non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472279 n.434T>G non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.66 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472380 n.535G>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472427 n.582T>G non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472484 n.639A>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472506 n.661A>T non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472572 n.727T>A non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472591 n.746G>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472812 n.967A>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473047 n.1202C>T non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473110 n.1265T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473157 n.1312C>T non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443delCinsAGTTT non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473298 n.1453A>G non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473305 n.1460G>T non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473673 n.16G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473719 n.62G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473721 n.64G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473722 n.65G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473884 n.227C>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1473887 n.230T>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473889 n.232G>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1473898 n.241C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474171 n.514C>G non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630T>A non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474290 n.633T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474292 n.635_651delTTCCTCTCCGGAGGAGGinsGGTT non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474355 n.698A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474406 n.749T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474520 n.863A>C non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474694 n.1037C>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGGTTC non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474753 n.1096_1097delACinsT non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474806 n.1149A>G non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474822 n.1165G>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>A non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474927 n.1271delC non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474945 n.1288C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475109 n.1452C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475175 n.1518G>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475176 n.1519G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475187 n.1530C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475188 n.1531C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475500 n.1843_1844insT non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475536 n.1879C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid Uncertain significance
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475650 n.1993A>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475697 n.2040C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105_2106delGCinsTT non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475762 n.2106C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475990 n.2333G>C non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476336 n.2679C>G non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476368 n.2711T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1476519 n.2862C>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476534 n.2877A>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.9 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.9 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476670 n.3013A>G non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rpsA 1833668 p.Ile43Val missense_variant 0.48 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.45 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833682 c.141C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833698 p.Leu53Val missense_variant 0.3 pyrazinamide
rpsA 1834046 p.Ile169Val missense_variant 0.29 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834090 c.549G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834354 c.813G>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834361 c.820_822delTTGinsCC frameshift_variant&missense_variant 0.45 pyrazinamide Uncertain significance
rpsA 1834366 c.825A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834378 c.837T>G synonymous_variant 0.57 pyrazinamide
rpsA 1834387 c.846C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834395 p.Arg285Gln missense_variant 0.66 pyrazinamide
rpsA 1834405 c.864C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834416 p.Ala292Val missense_variant 0.53 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.71 pyrazinamide Uncertain significance
rpsA 1834465 c.924T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.74 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.54 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.55 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.47 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518076 c.-39C>T upstream_gene_variant 0.86 isoniazid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
clpC1 4039773 p.Lys311Met missense_variant 0.58 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.6 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4039808 c.897G>A synonymous_variant 0.58 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.5 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.48 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.48 pyrazinamide
clpC1 4039838 c.865_867delCTGinsAC frameshift_variant&missense_variant 0.53 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039853 c.852G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039865 c.840T>A synonymous_variant 0.45 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.52 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039976 p.Lys243Thr missense_variant 0.48 pyrazinamide
clpC1 4039982 p.Thr241Ile missense_variant 0.5 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.55 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.62 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.63 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.55 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.66 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.69 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.63 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.71 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>T synonymous_variant 0.56 pyrazinamide
clpC1 4040081 c.624C>G synonymous_variant 0.53 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin