TB-Profiler result

Run: ERR978767
Summary

Run ID: ERR978767

Sample name:

Date: 2024-04-15T16:50:40.960165

Number of reads: 926787

Percentage reads mapped: 28.37

Median coverage: 32.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: RR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1321_1323delTCGinsGC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Leu443Met Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Leu464Met Mutation from literature
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761127 c.1321_1323delTCGinsGC frameshift_variant&missense_variant 0.44 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761133 p.Leu443Met missense_variant 0.44 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761196 p.Leu464Met missense_variant 0.45 rifampicin Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0565c 656265 c.1204_1205delAC frameshift_variant 1.0 ethionamide Uncertain significance
nusG 734658 c.405A>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 761054 c.1248G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761058 p.Val418Thr missense_variant 0.38 rifampicin
rpoB 761084 c.1278C>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.41 rifampicin
rpoB 761096 c.1290G>C synonymous_variant 0.42 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.41 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.42 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761138 c.1332C>G synonymous_variant 0.44 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761156 c.1350G>C synonymous_variant 0.44 rifampicin
rpoB 761165 c.1359G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761174 c.1368T>C synonymous_variant 0.46 rifampicin
rpoB 761177 c.1371G>C synonymous_variant 0.45 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.46 rifampicin
rpoB 761183 c.1377T>C synonymous_variant 0.47 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761193 p.Gly463Ser missense_variant 0.45 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.48 rifampicin
rpoB 761217 c.1411_1413delCCGinsAC frameshift_variant&missense_variant 0.48 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761243 c.1437G>C synonymous_variant 0.44 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761250 p.Thr482Ser missense_variant 0.41 rifampicin
rpoB 761261 c.1455G>A synonymous_variant 0.31 rifampicin
rpoB 762024 p.Val740Leu missense_variant 0.18 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.28 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762068 c.2262C>T synonymous_variant 0.29 rifampicin
rpoB 762080 c.2274G>C synonymous_variant 0.38 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.44 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.43 rifampicin
rpoB 762126 p.Val774Thr missense_variant 0.43 rifampicin
rpoB 762135 p.Asp777Asn missense_variant 0.44 rifampicin Uncertain significance
rpoB 762140 c.2334G>C synonymous_variant 0.44 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.43 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.45 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762180 p.Asp792Ser missense_variant 0.41 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.39 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762842 c.-528G>C upstream_gene_variant 0.36 rifampicin
rpoB 762855 p.Val1017Ile missense_variant 0.43 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.44 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.5 rifampicin
rpoB 762887 c.3081G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.65 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.62 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.57 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.6 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.59 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.57 rifampicin Not assoc w R
rpoB 763035 p.Tyr1077His missense_variant 0.57 rifampicin
rpoB 763038 p.Thr1078Ala missense_variant 0.57 rifampicin
rpoC 763043 c.-327G>C upstream_gene_variant 0.53 rifampicin
rpoB 763050 c.3244_3246delCTGinsAC frameshift_variant&missense_variant 0.53 rifampicin
rpoB 763053 c.3247_3249delTTGinsCC frameshift_variant&missense_variant 0.53 rifampicin
rpoB 763059 p.Ile1085Val missense_variant 0.52 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763072 c.3268_3270delACC conservative_inframe_deletion 0.53 rifampicin
rpoB 763078 c.3272_3273insGAA disruptive_inframe_insertion 0.53 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.48 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763119 p.Asn1105Asp missense_variant 0.46 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763130 p.Glu1108Asp missense_variant 0.43 rifampicin
rpoC 763133 c.-237G>C upstream_gene_variant 0.43 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.39 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763462 c.93G>C synonymous_variant 0.43 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.55 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>A synonymous_variant 0.58 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.61 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.62 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.62 rifampicin
rpoC 763537 c.168C>T synonymous_variant 0.61 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Ala missense_variant 0.62 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763578 p.Phe70Tyr missense_variant 0.72 rifampicin
rpoC 763589 p.Ile74Val missense_variant 0.74 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.75 rifampicin Uncertain significance
rpoC 763630 c.261G>C synonymous_variant 0.75 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.74 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763647 p.Gly93Ala missense_variant 0.76 rifampicin
rpoC 763655 p.Glu96Lys missense_variant 0.74 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763672 c.303C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.59 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.58 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.49 rifampicin
rpoC 763724 p.Asp119Asn missense_variant 0.49 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.48 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.4 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.38 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.22 rifampicin
rpoC 764468 p.Val367Ile missense_variant 0.27 rifampicin
rpoC 764485 c.1116G>C synonymous_variant 0.34 rifampicin
rpoC 764497 p.Glu376Asp missense_variant 0.35 rifampicin
rpoC 764498 p.Ser377Ala missense_variant 0.35 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.38 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>G synonymous_variant 0.37 rifampicin
rpoC 764536 c.1167G>C synonymous_variant 0.37 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764544 c.1176_1177delCG frameshift_variant 0.37 rifampicin
rpoC 764549 p.Pro394Ala missense_variant 0.36 rifampicin
rpoC 764551 c.1182_1183insTC frameshift_variant 0.37 rifampicin
rpoC 764560 c.1191T>G synonymous_variant 0.39 rifampicin
rpoC 764572 c.1203G>C synonymous_variant 0.43 rifampicin
rpoC 764575 c.1206T>C synonymous_variant 0.4 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.46 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.46 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.52 rifampicin
rpoC 764620 c.1251G>C synonymous_variant 0.52 rifampicin
rpoC 764623 c.1254C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.53 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764671 c.1302G>C synonymous_variant 0.53 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.45 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764703 p.Lys445Ser missense_variant 0.41 rifampicin
rpoC 764705 c.1336_1338delCTGinsGC frameshift_variant&missense_variant 0.41 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764722 c.1353G>C synonymous_variant 0.41 rifampicin
rpoC 764731 c.1362G>C synonymous_variant 0.4 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.39 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.38 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.39 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764755 p.Asp462Glu missense_variant 0.38 rifampicin
rpoC 764761 p.Asn464Lys missense_variant 0.39 rifampicin
rpoC 764762 c.1393_1395delCATinsGG frameshift_variant&missense_variant 0.4 rifampicin
rpoC 764767 c.1398G>C synonymous_variant 0.41 rifampicin
rpoC 764774 p.Ile469Val missense_variant 0.41 rifampicin
rpoC 764780 p.Ser471Ala missense_variant 0.43 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.38 rifampicin
rpoC 764807 p.Arg480Asn missense_variant 0.33 rifampicin
rpoC 764813 c.1444_1446delCAAinsAG frameshift_variant&missense_variant 0.31 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.27 rifampicin
rpoC 764832 p.Glu488Ala missense_variant 0.27 rifampicin
rpoC 764843 p.Ala492Arg missense_variant 0.24 rifampicin
rpoC 764858 c.1489_1491delTTGinsCC frameshift_variant&missense_variant 0.19 rifampicin
rpoC 764863 c.1494G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.24 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.24 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.17 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781275 c.-285A>C upstream_gene_variant 1.0 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.3 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.34 streptomycin
rpsL 781679 c.120C>G synonymous_variant 0.32 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.32 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.32 streptomycin
rpsL 781703 c.144G>C synonymous_variant 0.32 streptomycin
rpsL 781709 c.150G>T synonymous_variant 0.32 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.33 streptomycin
rpsL 781724 c.166_172delAAGTTGA frameshift_variant 0.34 streptomycin Uncertain significance
rpsL 781734 c.175delAinsCCTCTC frameshift_variant&missense_variant 0.33 streptomycin Uncertain significance
rpsL 781738 p.Gln60Pro missense_variant 0.35 streptomycin
rpsL 781740 c.181_182insCA frameshift_variant 0.35 streptomycin Uncertain significance
rpsL 781751 c.192G>C synonymous_variant 0.38 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.36 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.35 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>G synonymous_variant 0.34 streptomycin
rpsL 781781 c.222G>C synonymous_variant 0.33 streptomycin
rpsL 781796 p.Met79Ile missense_variant 0.32 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.32 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.31 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.33 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.33 streptomycin
rpsL 781829 c.270G>T synonymous_variant 0.28 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.26 streptomycin
rplC 800618 c.-191T>C upstream_gene_variant 0.16 linezolid
rplC 800632 c.-177_-176delATinsTC upstream_gene_variant 0.2 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.21 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.2 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.19 linezolid
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.18 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.18 linezolid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>G non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472295 n.450A>C non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472298 n.454delT non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472302 n.457G>A non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472305 n.460_467delTTCTCTCGinsCCTTATTCGCCT non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472330 n.485G>T non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472425 n.580T>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472427 n.582T>G non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472436 n.591G>T non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472437 n.592T>G non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>C non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472451 n.606C>T non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472462 n.617T>G non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472467 n.622G>T non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472484 n.639A>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472486 n.641A>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472673 n.828_829delTTinsGGC non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472682 n.837T>G non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>G non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472686 n.841G>C non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472837 n.992delCinsTGAGCG non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472843 n.998A>C non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472846 n.1002_1005delGTCT non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472856 n.1012_1013delAG non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472862 n.1017T>G non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472863 n.1019_1020insTCCC non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472872 n.1028_1034delCCTGTGT non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.94 streptomycin Not assoc w R
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473284 n.1439A>T non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473287 n.1442_1449delCCTCGGGAinsG non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473314 n.1469A>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>C non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474634 n.977T>C non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474658 n.1001A>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474667 n.1010G>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474683 n.1026C>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474711 n.1054_1059delGGTGTAinsTCGGGTTG non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474717 n.1060A>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474722 n.1065T>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096_1097delACinsG non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475026 n.1369G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475031 n.1374G>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475059 n.1403_1404insTA non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475065 n.1409_1411delCAA non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475076 n.1419_1422delCCTTinsACCCTA non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475080 n.1425_1426delCC non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475172 n.1515A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475518 n.1861A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475521 n.1864T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475526 n.1869C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475529 n.1872A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475532 n.1875A>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475538 n.1881T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475555 n.1898T>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid Uncertain significance
rrl 1475602 n.1945G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475605 n.1948_1950delATAinsG non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475610 n.1953G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475619 n.1962_1963delCTinsGTGCC non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475631 n.1975_1982delCGGGATCC non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475760 n.2103C>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475767 n.2110G>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid Uncertain significance
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475892 n.2235A>C non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476207 n.2550T>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476267 n.2610G>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476276 n.2619C>A non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>A non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476306 n.2649A>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476307 n.2650A>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476311 n.2654G>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476600 n.2943A>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476633 n.2976A>G non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476664 n.3007T>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476668 n.3011C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476680 n.3023T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rpsA 1833661 c.120A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833668 p.Ile43Val missense_variant 0.26 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.37 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.47 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833732 p.Pro64Leu missense_variant 0.48 pyrazinamide
rpsA 1833736 c.195C>T synonymous_variant 0.47 pyrazinamide
rpsA 1833739 c.198C>T synonymous_variant 0.47 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.48 pyrazinamide
rpsA 1833770 p.Asn77Asp missense_variant 0.49 pyrazinamide
rpsA 1833776 p.Val79Ile missense_variant 0.48 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.47 pyrazinamide
rpsA 1833797 p.Val86Ile missense_variant 0.49 pyrazinamide Uncertain significance
rpsA 1833802 c.261A>G synonymous_variant 0.48 pyrazinamide
rpsA 1833808 c.267G>T synonymous_variant 0.45 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.45 pyrazinamide
rpsA 1833815 p.Thr92Gln missense_variant 0.46 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.46 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.46 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833842 p.Ile101Leu missense_variant 0.46 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833848 c.307_308delTCinsAG synonymous_variant 0.47 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.49 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.51 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.54 pyrazinamide
rpsA 1833877 c.336C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833892 c.351_352insC frameshift_variant 0.57 pyrazinamide Uncertain significance
rpsA 1833895 c.355delC frameshift_variant 0.56 pyrazinamide Uncertain significance
rpsA 1833905 p.Lys122Glu missense_variant 0.55 pyrazinamide
rpsA 1833912 p.Glu124Gly missense_variant 0.54 pyrazinamide
rpsA 1833915 p.Ala125Val missense_variant 0.54 pyrazinamide Uncertain significance
rpsA 1833921 p.Lys127Thr missense_variant 0.56 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.5 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.49 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.46 pyrazinamide
rpsA 1833973 c.432G>T synonymous_variant 0.45 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.45 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834034 c.493_495delATCinsGG frameshift_variant&missense_variant 0.4 pyrazinamide Uncertain significance
rpsA 1834040 p.Lys167Arg missense_variant 0.39 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.39 pyrazinamide
rpsA 1834054 c.513C>A synonymous_variant 0.39 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834114 c.573G>T synonymous_variant 0.38 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834140 p.Ser200Thr missense_variant 0.15 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.54 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.59 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834307 c.766_768delGACinsCG frameshift_variant&missense_variant 0.62 pyrazinamide Uncertain significance
rpsA 1834327 c.786G>C synonymous_variant 0.66 pyrazinamide
rpsA 1834340 c.799_801delATGinsTC frameshift_variant&missense_variant 0.65 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834360 c.819G>C synonymous_variant 0.68 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>G synonymous_variant 0.67 pyrazinamide
rpsA 1834384 c.843A>G synonymous_variant 0.66 pyrazinamide
rpsA 1834395 p.Arg285Gln missense_variant 0.65 pyrazinamide
rpsA 1834397 p.His286Ala missense_variant 0.65 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.62 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834427 p.Ile296Val missense_variant 0.58 pyrazinamide Uncertain significance
rpsA 1834432 c.891G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.51 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834468 c.927A>C synonymous_variant 0.5 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.46 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834523 p.Glu328Gln missense_variant 0.36 pyrazinamide
rpsA 1834546 p.Asp335Glu missense_variant 0.18 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918631 p.Pro231Arg missense_variant 1.0 capreomycin
PPE35 2168149 p.Pro822Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv2680 2995848 c.-257G>A upstream_gene_variant 1.0 capreomycin
Rv3236c 3613636 c.-520A>G upstream_gene_variant 1.0 pyrazinamide Not assoc w R
mtrA 3627020 c.330G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
clpC1 4039729 p.Asp326Asn missense_variant 0.98 pyrazinamide Not assoc w R
clpC1 4040063 c.642G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040096 c.609G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040110 c.595C>A synonymous_variant 0.23 pyrazinamide
clpC1 4040114 p.Ile197Met missense_variant 0.23 pyrazinamide
clpC1 4040117 c.588A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040123 c.580_582delGAGinsCC frameshift_variant&missense_variant 0.23 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.23 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R