TB-Profiler result

Run: ERR126597
Summary

Run ID: ERR126597

Sample name:

Date: 2024-04-15T13:30:31.760265

Number of reads: 3558465

Percentage reads mapped: 34.58

Median coverage: 75.0

Strain: lineage4.4.1.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.4.1.2 Euro-American None 0.99
lineage4.4.1 Euro-American (S-type) None 1.0
lineage4 Euro-American None 1.0
lineage4.4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser140Asn Uncertain significance Mutation from literature
ethambutol
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.75 capreomycin Assoc w R
amikacin Assoc w R
kanamycin Assoc w R
katG 2155693 p.Ser140Asn missense_variant 0.2 isoniazid Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rpoB 761021 c.1215G>C synonymous_variant 0.12 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>A synonymous_variant 0.46 rifampicin
rpoB 761066 c.1260G>C synonymous_variant 0.46 rifampicin
rpoB 761084 c.1278C>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761087 c.1281C>G synonymous_variant 0.45 rifampicin
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.45 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.45 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.47 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.42 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761159 c.1353G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761162 c.1356G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761186 p.Glu460Asp missense_variant 0.19 rifampicin Uncertain significance
rpoB 761552 c.1746G>C synonymous_variant 0.25 rifampicin
rpoB 761558 c.1752C>A synonymous_variant 0.27 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761565 p.Met587Leu missense_variant 0.29 rifampicin
rpoB 761573 c.1767C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.42 rifampicin
rpoB 761603 c.1797C>A synonymous_variant 0.43 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.39 rifampicin
rpoB 761649 c.1843_1844delAGinsTC synonymous_variant 0.23 rifampicin
rpoB 761661 c.1855_1857delCTGinsTC frameshift_variant&missense_variant 0.16 rifampicin
rpoB 762160 p.Arg785His missense_variant 0.13 rifampicin
rpoB 762177 p.Arg791Glu missense_variant 0.2 rifampicin
rpoB 762181 p.Asp792Ala missense_variant 0.21 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762200 c.2394C>A synonymous_variant 0.33 rifampicin
rpoB 762221 c.2415G>A synonymous_variant 0.34 rifampicin
rpoB 762227 c.2421G>A synonymous_variant 0.35 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.31 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.22 rifampicin
rpoB 762273 p.Ala823Ser missense_variant 0.22 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.17 rifampicin
rpoB 762849 c.3043_3045delTACinsGT frameshift_variant&missense_variant 0.25 rifampicin
rpoB 762855 p.Val1017Ile missense_variant 0.25 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.27 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.4 rifampicin Uncertain significance
rpoB 762887 c.3081G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 762938 c.-432G>C upstream_gene_variant 0.38 rifampicin
rpoC 762947 c.-423C>G upstream_gene_variant 0.34 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762971 c.3165G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.18 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763507 c.138G>C synonymous_variant 0.47 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.49 rifampicin
rpoC 763532 c.163_165delACTinsTC frameshift_variant&missense_variant 0.49 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763600 c.231C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763609 c.240C>T synonymous_variant 0.44 rifampicin
rpoC 763612 c.243G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763630 c.261G>C synonymous_variant 0.41 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764308 c.939G>C synonymous_variant 0.27 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764347 c.978G>C synonymous_variant 0.38 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.38 rifampicin
rpoC 764359 c.990C>G synonymous_variant 0.37 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.3 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.24 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.25 rifampicin
rpoC 764498 c.1129_1131delTCCinsGT frameshift_variant&missense_variant 0.24 rifampicin
rpoC 764503 c.1134G>T synonymous_variant 0.25 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.26 rifampicin
rpoC 764512 c.1143G>C synonymous_variant 0.27 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>G synonymous_variant 0.55 rifampicin
rpoC 764548 c.1179G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.51 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.5 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.48 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.5 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.58 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.59 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>T synonymous_variant 0.58 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.6 rifampicin
rpoC 764706 p.Leu446Gln missense_variant 0.61 rifampicin Uncertain significance
rpoC 764722 c.1353G>C synonymous_variant 0.53 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.53 rifampicin
rpoC 764752 c.1383G>T synonymous_variant 0.53 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>C synonymous_variant 0.53 rifampicin
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.48 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764804 c.1435_1437delCAGinsTC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.45 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764837 p.Val490Ile missense_variant 0.47 rifampicin Uncertain significance
rpoC 764843 p.Ala492Thr missense_variant 0.45 rifampicin
rpoC 764848 c.1479G>A synonymous_variant 0.42 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.33 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.25 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.26 rifampicin
rpoC 764911 c.1542A>C synonymous_variant 0.18 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.18 rifampicin Uncertain significance
rpoC 764917 c.1548G>T synonymous_variant 0.19 rifampicin
rpoC 764920 c.1551G>T synonymous_variant 0.2 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.29 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764958 p.Glu530Gly missense_variant 0.32 rifampicin
rpoC 764962 c.1593G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>A synonymous_variant 0.44 rifampicin
rpoC 764998 c.1629G>A synonymous_variant 0.44 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765014 p.Ala549Pro missense_variant 0.4 rifampicin
rpoC 765022 c.1653G>C synonymous_variant 0.36 rifampicin
rpoC 765028 c.1659C>T synonymous_variant 0.35 rifampicin
rpoC 765034 c.1665T>C synonymous_variant 0.31 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800639 c.-170C>T upstream_gene_variant 0.15 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.16 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.16 linezolid
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.18 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.18 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.19 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.19 linezolid
rplC 800702 c.-107G>T upstream_gene_variant 0.19 linezolid
rplC 800703 c.-106_-104delTTGinsCT upstream_gene_variant 0.19 linezolid
rplC 800729 c.-80G>C upstream_gene_variant 0.16 linezolid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.12 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472495 n.650C>A non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>T non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472674 n.829T>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472837 n.992C>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473278 n.1433T>C non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473834 n.177_179delGGAinsTGGG non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474166 n.509G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474311 n.654G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474381 n.724T>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474409 n.756_776delACCCACACGCGCATACGCGCG non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474437 n.782_784delATA non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474450 n.793T>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474664 n.1007G>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474723 n.1066G>A non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>C non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474869 n.1212G>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475093 n.1436C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475111 n.1454G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475119 n.1462C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475488 n.1831G>C non_coding_transcript_exon_variant 0.11 capreomycin
linezolid
rrl 1475515 n.1858G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid Uncertain significance
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475766 n.2109G>C non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475996 n.2339T>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476024 n.2367T>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476308 n.2651G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.78 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476586 n.2929C>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476596 n.2939C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476601 n.2944G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476613 n.2956G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833734 p.Ala65Ser missense_variant 0.19 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833763 c.222C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1833766 c.225C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833770 p.Asn77Gly missense_variant 0.28 pyrazinamide
rpsA 1833775 c.234G>A synonymous_variant 0.28 pyrazinamide
rpsA 1833778 c.237C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833794 p.Glu85Gln missense_variant 0.3 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.3 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.23 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.13 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.13 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833955 c.414G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.34 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.38 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834025 p.Gln162Ala missense_variant 0.36 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.41 pyrazinamide
rpsA 1834043 p.Glu168Gln missense_variant 0.42 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.44 pyrazinamide
rpsA 1834066 c.525G>A synonymous_variant 0.37 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834096 c.555G>T synonymous_variant 0.3 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.24 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834234 c.693G>A synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.34 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834252 c.711C>T synonymous_variant 0.35 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.34 pyrazinamide
rpsA 1834298 c.757_759delCAGinsGA frameshift_variant&missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1834306 c.765T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834307 c.766_768delGACinsCG frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834312 c.771G>A synonymous_variant 0.3 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.35 pyrazinamide
rpsA 1834333 p.Asp264Glu missense_variant 0.32 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102990 p.Val18Ala missense_variant 0.99 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Not assoc w R
katG 2155680 c.432G>A synonymous_variant 0.13 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.21 isoniazid
katG 2155701 c.411C>T synonymous_variant 0.27 isoniazid Not assoc w R - Interim
katG 2155716 c.396T>G synonymous_variant 0.27 isoniazid
katG 2155722 c.390G>A synonymous_variant 0.27 isoniazid
katG 2155734 p.Met126Ser missense_variant 0.27 isoniazid
katG 2155741 p.Gly124Asp missense_variant 0.28 isoniazid Uncertain significance
katG 2155746 c.366C>A synonymous_variant 0.28 isoniazid Not assoc w R - Interim
katG 2155769 p.Ile115Val missense_variant 0.28 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.17 isoniazid
PPE35 2167770 p.Ser948Ile missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169840 p.Gly258Asp missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2170066 p.Ala183Thr missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pepQ 2860213 p.Pro69Leu missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
ribD 2986868 c.30T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067754 c.192C>T synonymous_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448608 c.105G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
clpC1 4038845 c.1860G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038854 p.Lys617Arg missense_variant 0.19 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038863 c.1842G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038899 c.1806C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.19 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038923 c.1782A>C synonymous_variant 0.16 pyrazinamide
clpC1 4039714 p.Tyr331His missense_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039730 c.975C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039773 p.Lys311Met missense_variant 0.16 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.33 pyrazinamide
clpC1 4039931 c.774T>A synonymous_variant 0.34 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.33 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.32 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039981 p.Leu242Ile missense_variant 0.37 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.35 pyrazinamide
clpC1 4040001 p.His235Arg missense_variant 0.38 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040018 c.687G>T synonymous_variant 0.4 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040087 c.618G>A synonymous_variant 0.19 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040096 c.609G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.14 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040360 c.345G>A synonymous_variant 0.19 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.2 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040390 c.315C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040417 c.288G>C synonymous_variant 0.15 pyrazinamide
embC 4238963 c.-900C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4249012 c.2499G>A synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin