TB-Profiler result

Run: SRR1162864
Summary

Run ID: SRR1162864

Sample name:

Date: 2024-10-04T19:25:33.251977

Number of reads: 1737898

Percentage reads mapped: 73.11

Median coverage: 39.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.96
lineage4.1.2 Euro-American None 0.98
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.97
lineage4 Euro-American None 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.33 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.2 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.19 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.19 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.21 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.22 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.26 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.2 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.18 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.17 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.17 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.18 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.18 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.19 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.26 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.23 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.22 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.21 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.2 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.19 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.19 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.18 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.18 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.17 isoniazid
dnaA 1302 c.1302C>G synonymous_variant 0.16 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.19 isoniazid
dnaA 1419 c.1419C>G synonymous_variant 0.19 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.21 isoniazid
dnaA 1461 c.1461C>A synonymous_variant 0.16 isoniazid
gyrB 6169 c.930C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8054 c.753T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8057 c.756A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8093 c.792C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8348 c.1047C>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8363 c.1062C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419Gln missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8562 c.1261C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8720 c.1419G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8829 c.1528T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8951 c.1650G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
fgd1 491526 c.744T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491532 c.750G>T synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491542 c.760T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491583 c.801G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491591 p.Lys270Met missense_variant 0.82 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
fgd1 491595 c.813C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
mshA 575679 p.Asn111Ser missense_variant 0.92 isoniazid Not assoc w R
ethionamide Not assoc w R
mshA 575746 c.399C>G synonymous_variant 0.36 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.36 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.34 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.36 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.24 isoniazid
ethionamide
ccsA 619574 c.-317G>A upstream_gene_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 619579 c.-312G>C upstream_gene_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 619591 c.-300G>C upstream_gene_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620245 c.355T>C synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620269 p.Val127Ile missense_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620778 c.888T>C synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620784 c.894C>G synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620787 c.897C>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620809 c.919C>T synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620829 c.939G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620838 c.948C>T synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620844 c.954C>T synonymous_variant 0.15 kanamycin
capreomycin
amikacin
Rv0565c 657291 c.180C>G synonymous_variant 0.2 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.17 ethionamide
Rv0565c 657678 c.-208A>G upstream_gene_variant 0.18 ethionamide
Rv0565c 657690 c.-220C>A upstream_gene_variant 0.15 ethionamide
hadA 731741 c.-189G>A upstream_gene_variant 0.16 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.21 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.22 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.24 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.25 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.25 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.26 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.16 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.17 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.19 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.18 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.18 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.18 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.22 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.26 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.27 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.31 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.26 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.26 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.25 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.25 isoniazid
nusG 734376 c.123G>A synonymous_variant 0.2 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.28 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.33 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.34 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.39 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.35 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.39 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.42 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.37 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.33 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.23 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.77 rifampicin Not assoc w R
rpoB 760118 c.312T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.26 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.33 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.26 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.26 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.22 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.22 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.26 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.25 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.32 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.22 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.17 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.15 rifampicin Uncertain significance
rpoB 760611 c.805T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.35 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.21 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.18 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.26 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.25 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.29 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.26 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.31 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.34 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.38 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.44 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.46 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.51 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.38 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.34 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.23 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.36 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.33 rifampicin
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.26 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761222 c.1416G>C synonymous_variant 0.36 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.34 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.34 rifampicin
rpoB 761373 p.Val523His missense_variant 0.35 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761531 c.1725C>G synonymous_variant 0.24 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.24 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.2 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.22 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.22 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.24 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.24 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.28 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.29 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.28 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.29 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.22 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.24 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.25 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.27 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.3 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.22 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.29 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.26 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.25 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.24 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.26 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>T upstream_gene_variant 0.31 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.32 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.31 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.29 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.27 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.29 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.19 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.19 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.19 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.21 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.19 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.22 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.3 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.22 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.25 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.24 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.22 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.24 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.17 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.22 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.21 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.27 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.29 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.29 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.28 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.26 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.26 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.24 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.22 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.26 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.27 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.33 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.3 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.25 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.28 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.28 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.26 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.27 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.21 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.21 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.21 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.18 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.22 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.2 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.23 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.31 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.42 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.43 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.32 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.33 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.35 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.25 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.3 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.19 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765300 p.Val644Ala missense_variant 0.18 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765325 c.1956C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.17 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.18 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.24 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.24 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.22 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.23 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.34 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.34 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.36 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.29 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.26 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.28 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.27 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.26 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.26 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.29 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.27 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.31 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.31 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.27 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.28 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.26 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.39 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.35 rifampicin
rpoC 766015 c.2646G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.37 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.41 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.46 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.37 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.4 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.42 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.4 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.39 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.32 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.23 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.38 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.36 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.36 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.37 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 0.37 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.38 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.3 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.29 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.28 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766528 c.3159T>G synonymous_variant 0.21 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.31 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.3 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.28 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.25 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.24 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.22 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.26 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.27 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.32 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.3 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.3 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.29 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.24 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.32 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.37 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.35 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.39 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.45 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.38 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.36 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.33 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.31 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.27 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775966 p.Ala839Ser missense_variant 0.2 bedaquiline
clofazimine
mmpL5 775975 c.2506T>C synonymous_variant 0.21 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.24 bedaquiline
clofazimine
mmpL5 775997 c.2484T>C synonymous_variant 0.23 bedaquiline
clofazimine
mmpL5 776000 c.2481G>C synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 776008 p.His825Tyr missense_variant 0.18 bedaquiline
clofazimine
mmpL5 776009 c.2472A>G synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 776646 p.Val612Thr missense_variant 0.16 bedaquiline
clofazimine
mmpL5 776654 c.1827A>T synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 776663 p.Thr606Ala missense_variant 0.19 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 776678 c.1803G>C synonymous_variant 0.21 bedaquiline
clofazimine
mmpL5 776693 c.1788C>G synonymous_variant 0.21 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.16 streptomycin
rpsL 781608 p.Ser17Gly missense_variant 0.24 streptomycin
rpsL 781631 c.72G>C synonymous_variant 0.35 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.43 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.45 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.43 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.3 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.28 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.25 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.24 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.3 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.39 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.48 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.41 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.36 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.38 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.35 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.34 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.32 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.33 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.3 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.21 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.26 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.26 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.26 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.25 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.21 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.29 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.28 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.27 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.28 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.29 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.31 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.27 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.21 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.19 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.17 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.2 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.23 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.25 linezolid
rplC 800794 c.-15_-9delAGATTGGinsGAGTT upstream_gene_variant 0.19 linezolid
rplC 800814 c.6A>G synonymous_variant 0.2 linezolid
rplC 800817 c.9A>T synonymous_variant 0.22 linezolid
rplC 800844 c.36T>C synonymous_variant 0.27 linezolid
rplC 800865 c.57A>G synonymous_variant 0.2 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.19 linezolid
rplC 800874 c.66A>G synonymous_variant 0.21 linezolid
rplC 800877 c.69A>C synonymous_variant 0.22 linezolid
rplC 800880 c.72A>G synonymous_variant 0.23 linezolid
rplC 800889 c.81C>G synonymous_variant 0.26 linezolid
rplC 800907 c.99C>G synonymous_variant 0.26 linezolid
rplC 800916 c.108A>G synonymous_variant 0.24 linezolid
rplC 801312 c.504G>C synonymous_variant 0.36 linezolid
rplC 801324 c.516T>C synonymous_variant 0.36 linezolid
rplC 801336 c.528C>G synonymous_variant 0.33 linezolid
rplC 801339 c.531T>C synonymous_variant 0.33 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.33 linezolid
rplC 801348 c.540T>G synonymous_variant 0.36 linezolid
rplC 801357 c.549T>C synonymous_variant 0.37 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.42 linezolid
rplC 801396 c.588T>C synonymous_variant 0.39 linezolid
rplC 801402 c.594T>C synonymous_variant 0.33 linezolid
fbiC 1303560 c.630G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303716 c.786C>T synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.26 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1303881 c.951G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303911 c.981G>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303923 c.993C>T synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303929 c.999G>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303973 p.Gly348Ala missense_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303981 p.Val351Ile missense_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303995 c.1065C>T synonymous_variant 0.39 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304034 c.1104A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304574 c.1644C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304628 c.1698G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.33 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304754 c.1824G>A synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>G synonymous_variant 0.31 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.3 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304872 c.1942_1944delAGCinsTCG synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304877 c.1947T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304878 c.1948_1950delCGCinsAGG synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305381 c.2451G>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1305393 c.2463T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305405 c.2475A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1305420 c.2490C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305423 c.2493T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305430 p.Val834Thr missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305444 c.2514A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
sigE 1364712 c.300T>C synonymous_variant 0.22 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.2 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.23 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.21 pyrazinamide
sigE 1364748 c.336G>C synonymous_variant 0.19 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.22 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.25 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.22 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.29 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.34 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.35 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.31 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.3 pyrazinamide
sigE 1364866 p.Ala152Ser missense_variant 0.31 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.27 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.21 pyrazinamide
atpE 1461159 p.Val39Ile missense_variant 0.26 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.29 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.29 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.25 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.24 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.23 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.2 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.16 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
inhA 1673574 c.-628C>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673580 c.-622T>C upstream_gene_variant 0.26 isoniazid Uncertain significance
ethionamide
inhA 1673589 c.-613A>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1674279 c.78A>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674280 p.Arg27Lys missense_variant 0.19 isoniazid
ethionamide
inhA 1674285 c.84A>G synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674452 p.Ala84Glu missense_variant 0.21 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.47 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.46 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.48 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.48 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.45 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.35 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.31 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674627 c.426T>G synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.39 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.42 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.37 isoniazid
ethionamide
inhA 1674693 c.492C>G synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.34 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.31 isoniazid
ethionamide
rpsA 1833541 c.-1T>C upstream_gene_variant 0.2 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.35 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.37 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.29 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.29 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834201 c.660C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.37 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.39 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.27 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.3 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.35 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.32 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.29 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.32 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.29 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.26 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.23 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.21 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.26 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.29 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.29 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.23 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.2 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.2 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917934 c.-6T>C upstream_gene_variant 0.77 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063642 p.Asp363Tyr missense_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101966 c.1077T>G synonymous_variant 0.28 isoniazid
delamanid
ethionamide
ndh 2101972 c.1071G>C synonymous_variant 0.33 isoniazid
delamanid
ethionamide
ndh 2101978 p.Asn355Asp missense_variant 0.31 isoniazid
delamanid
ethionamide
ndh 2101988 p.Ala352Gly missense_variant 0.31 isoniazid
delamanid
ethionamide
ndh 2101990 c.1053G>T synonymous_variant 0.31 isoniazid
delamanid
ethionamide
ndh 2102009 p.Ser345Asn missense_variant 0.32 isoniazid
delamanid
ethionamide
ndh 2102020 c.1023A>G synonymous_variant 0.33 isoniazid
delamanid
ethionamide
ndh 2102023 c.1020G>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
delamanid
ethionamide
ndh 2102026 c.1017G>C synonymous_variant 0.35 isoniazid
delamanid
ethionamide
ndh 2102050 c.993T>C synonymous_variant 0.37 isoniazid
delamanid
ethionamide
ndh 2102053 c.990G>C synonymous_variant 0.32 isoniazid
delamanid
ethionamide
ndh 2102059 c.984T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
delamanid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
katG 2155020 c.1092C>T synonymous_variant 0.19 isoniazid
katG 2155029 c.1083C>G synonymous_variant 0.24 isoniazid
katG 2155032 c.1080T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
katG 2155054 p.Tyr353Phe missense_variant 0.31 isoniazid
katG 2155056 c.1056A>G synonymous_variant 0.31 isoniazid
katG 2155062 c.1050T>C synonymous_variant 0.28 isoniazid
katG 2155065 c.1047C>G synonymous_variant 0.28 isoniazid
katG 2155068 c.1044T>C synonymous_variant 0.29 isoniazid
katG 2155071 c.1041T>C synonymous_variant 0.31 isoniazid
katG 2155080 c.1032G>C synonymous_variant 0.33 isoniazid
katG 2155614 p.Val166Ile missense_variant 0.19 isoniazid Uncertain significance
katG 2155617 c.495T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
katG 2155632 c.480A>C synonymous_variant 0.21 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.2 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.21 isoniazid Uncertain significance
katG 2155677 c.435C>G synonymous_variant 0.16 isoniazid
PPE35 2170173 c.437_439dupTGG conservative_inframe_insertion 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517947 c.-168C>T upstream_gene_variant 0.41 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.38 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.35 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.37 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.24 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.23 isoniazid
kasA 2518031 c.-84G>T upstream_gene_variant 0.2 isoniazid
kasA 2518034 c.-81T>C upstream_gene_variant 0.2 isoniazid
kasA 2518035 c.-80C>G upstream_gene_variant 0.19 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.21 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.25 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.34 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.32 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.32 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.32 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.38 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.37 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.36 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.38 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.38 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.29 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.34 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.34 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.32 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.3 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.34 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.35 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.4 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.41 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.37 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.38 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.37 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.36 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.38 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.38 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.34 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.33 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.35 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.31 isoniazid
kasA 2519125 c.1011C>T synonymous_variant 0.32 isoniazid
kasA 2519137 c.1023T>C synonymous_variant 0.34 isoniazid
kasA 2519146 c.1032C>A synonymous_variant 0.3 isoniazid
kasA 2519167 c.1053T>C synonymous_variant 0.34 isoniazid
ahpC 2726336 c.144G>C synonymous_variant 0.23 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.33 isoniazid
ahpC 2726354 c.162G>C synonymous_variant 0.32 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.31 isoniazid Not assoc w R - Interim
ahpC 2726366 c.174G>C synonymous_variant 0.28 isoniazid
ahpC 2726579 c.387T>C synonymous_variant 0.17 isoniazid
ahpC 2726582 c.390G>C synonymous_variant 0.17 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.18 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.17 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.17 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.18 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.17 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.17 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.18 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.17 isoniazid
folC 2747302 c.297A>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.32 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.31 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.29 para-aminosalicylic_acid
folC 2747401 c.198G>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747407 c.192T>C synonymous_variant 0.28 para-aminosalicylic_acid
folC 2747411 p.Ser63Ala missense_variant 0.24 para-aminosalicylic_acid
folC 2747416 c.183A>G synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747419 c.180C>G synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747430 c.169C>T synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747439 p.Met54Leu missense_variant 0.19 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747443 c.156G>A synonymous_variant 0.19 para-aminosalicylic_acid
Rv2477c 2782450 c.1593C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782453 c.1590C>A synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782582 c.1461C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783320 c.723C>T synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783373 p.Glu224Gln missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.3 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783578 p.Glu155Asp missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.27 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.3 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784301 c.-259T>C upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784306 c.-264G>C upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784311 c.-269T>G upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784315 c.-273G>C upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784321 c.-279A>C upstream_gene_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784324 c.-282G>C upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784327 c.-285G>C upstream_gene_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784330 c.-288G>A upstream_gene_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784357 c.-316_-315delTTinsAC upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784366 c.-324G>C upstream_gene_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784375 c.-333T>C upstream_gene_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784381 c.-339T>C upstream_gene_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2680 2996136 p.Ser11Asn missense_variant 0.21 capreomycin
Rv2752c 3065687 p.Gly169Ser missense_variant 0.92 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065901 c.291A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065916 p.Phe92Tyr missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065919 c.273G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065925 p.Ala89Gly missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065928 c.264G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065947 p.Gly82Ala missense_variant 0.37 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065955 c.235_237delTTGinsCTC synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065979 c.213T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065993 p.Val67Ile missense_variant 0.26 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065997 c.195C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066002 p.Met64Leu missense_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066024 c.168T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066040 p.Gly51Thr missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066042 c.150T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066050 p.Leu48Met missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066054 c.138T>G synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066075 c.117A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066087 c.105A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3066118 p.Asn25Ser missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066756 c.-565G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067277 c.669C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067280 c.666G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067284 p.Ala221Asp missense_variant 0.21 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067293 p.Gln218Arg missense_variant 0.26 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.3 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.31 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.34 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073872 p.Ile200Val missense_variant 0.36 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.28 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074117 c.355C>T synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074155 p.Gly106Asp missense_variant 0.79 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612667 c.450T>G synonymous_variant 0.24 pyrazinamide
Rv3236c 3612673 c.444G>C synonymous_variant 0.26 pyrazinamide
Rv3236c 3612676 c.441A>G synonymous_variant 0.25 pyrazinamide
Rv3236c 3612685 c.432C>T synonymous_variant 0.24 pyrazinamide
Rv3236c 3612694 c.423T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
lpqB 3623512 p.Gly467Ser missense_variant 0.15 rifampicin
bedaquiline
lpqB 3624407 c.504C>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624422 c.489G>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624425 p.Glu162Ala missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624428 c.483A>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624452 c.459T>C synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624464 c.447A>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624713 c.198C>T synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624728 c.183C>T synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624755 c.154_156delTTAinsCTG synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624760 c.151C>T synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624770 c.141T>C synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624776 c.135T>C synonymous_variant 0.23 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625543 c.-633G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.31 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3625592 p.Ser341Asn missense_variant 0.31 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.35 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.29 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.32 rifampicin
bedaquiline
lpqB 3625627 c.-717C>T upstream_gene_variant 0.32 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.38 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.3 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625840 c.-930A>G upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625882 c.732G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625888 c.-978G>T upstream_gene_variant 0.37 rifampicin
bedaquiline
lpqB 3625909 c.-999T>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627170 c.-557C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTC upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3627323 p.Leu9Phe missense_variant 0.16 rifampicin
bedaquiline
fbiB 3642593 c.1059G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiB 3642602 c.1068A>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3642605 c.1071A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3642614 c.1080C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3642620 c.1086T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3642656 c.1122G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
rpoA 3877542 c.966C>T synonymous_variant 0.38 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.44 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.43 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.34 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.27 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.32 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.27 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.29 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.26 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.27 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.29 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.22 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.2 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.2 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.2 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.26 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.26 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.25 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.28 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.26 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.23 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.23 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.23 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.25 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.27 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.19 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.25 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.25 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.28 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.29 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.31 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.32 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.35 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.39 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.35 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.33 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.26 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.21 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.21 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.2 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.18 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.26 rifampicin
rpoA 3879012 c.-505C>T upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.29 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.32 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.35 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.29 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.32 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.38 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.39 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.39 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.26 rifampicin
clpC1 4038244 p.Thr821Ala missense_variant 0.26 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.36 pyrazinamide
clpC1 4038272 p.Gly811Ser missense_variant 0.36 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038308 p.Val799Ile missense_variant 0.3 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.26 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.26 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.31 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.3 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.2 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.2 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.33 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.3 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.27 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.31 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.22 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039388 c.1317C>A synonymous_variant 0.28 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.28 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039484 c.1221T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.28 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.39 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.22 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.26 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.3 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.24 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.21 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040477 c.228G>A synonymous_variant 0.25 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
panD 4044138 c.144T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>G synonymous_variant 0.16 pyrazinamide
panD 4044644 c.-363A>G upstream_gene_variant 0.17 pyrazinamide
panD 4044647 c.-366C>G upstream_gene_variant 0.17 pyrazinamide
panD 4044677 c.-396T>C upstream_gene_variant 0.18 pyrazinamide
panD 4044682 c.-401C>A upstream_gene_variant 0.18 pyrazinamide
panD 4044688 c.-407T>C upstream_gene_variant 0.2 pyrazinamide
panD 4044692 c.-411G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044700 c.-419C>A upstream_gene_variant 0.2 pyrazinamide
panD 4044704 c.-423G>T upstream_gene_variant 0.21 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.26 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.25 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.2 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.19 pyrazinamide
glpK 4138538 c.1218C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138541 c.1215C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138547 c.1209C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138571 c.1185C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138583 c.1173G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138586 c.1170C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138594 p.Asn388Asp missense_variant 0.4 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138606 c.1150T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138631 c.1125C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>T synonymous_variant 0.41 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.44 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138664 c.1092G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138667 c.1089G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.46 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138706 c.1050C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138715 c.1041G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139575 p.Val61Ile missense_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.32 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.45 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139630 c.126C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139651 p.His35Gln missense_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4239298 c.-565C>T upstream_gene_variant 0.89 ethambutol Not assoc w R
embC 4240594 c.732C>G synonymous_variant 0.19 ethambutol
embC 4240600 c.738G>C synonymous_variant 0.2 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.24 ethambutol
embC 4240654 c.792C>T synonymous_variant 0.2 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.23 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.26 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.29 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.3 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.31 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.33 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.38 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.36 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.34 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.35 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.34 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.28 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.25 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.23 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.23 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.23 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.2 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.21 ethambutol
embC 4240919 c.1057_1059delCTCinsTTG synonymous_variant 0.21 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.18 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.21 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.19 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.3 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.35 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.43 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.43 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.31 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.31 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.3 ethambutol
embC 4241443 c.1581C>G synonymous_variant 0.3 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.3 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.3 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.93 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.94 ethambutol Not assoc w R
embA 4245077 c.1845G>C synonymous_variant 0.2 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.21 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.21 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.2 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.21 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.32 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.33 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.22 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.22 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.22 ethambutol
embA 4245206 c.1974A>G synonymous_variant 0.18 ethambutol
embB 4246355 c.-159G>C upstream_gene_variant 0.23 ethambutol
embA 4246359 p.Ala1043Pro missense_variant 0.23 ethambutol
embB 4246364 c.-150G>C upstream_gene_variant 0.2 ethambutol
embB 4246367 c.-147C>T upstream_gene_variant 0.2 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.21 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.21 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.18 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.24 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.27 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.32 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.32 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.31 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.38 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.36 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.23 ethambutol
embB 4248052 c.1539G>A synonymous_variant 0.15 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.17 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.2 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.21 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.21 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.26 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.27 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.26 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.26 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.27 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.28 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.24 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.25 ethambutol
embB 4248298 c.1785C>T synonymous_variant 0.34 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.33 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.27 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.26 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.21 ethambutol
embB 4249420 c.2907G>C synonymous_variant 0.21 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.21 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.2 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.19 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.19 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.18 ethambutol
embB 4249456 c.2943G>C synonymous_variant 0.2 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.2 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin