TB-Profiler result

Run: ERR4818252
Summary

Run ID: ERR4818252

Sample name:

Date: 2024-10-04T01:55:11.124543

Number of reads: 270584

Percentage reads mapped: 16.51

Median coverage: 5.0

Strain: lineage4.1.1.2

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1.1.2 Euro-American (X-type) None 0.95
lineage4 Euro-American None 0.99
lineage4.1.1 Euro-American (X-type) None 0.22
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.71 isoniazid Not assoc w R - Interim
dnaA 747 c.747G>C synonymous_variant 0.69 isoniazid
dnaA 750 c.750C>G synonymous_variant 0.67 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.62 isoniazid
dnaA 767 p.Val256Ala missense_variant 0.43 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.5 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.46 isoniazid Not assoc w R - Interim
dnaA 921 c.921A>G synonymous_variant 0.75 isoniazid Not assoc w R - Interim
gyrB 6214 c.975G>C synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrB 6215 p.Ser326Thr missense_variant 0.9 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6718 c.-584C>T upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7412 c.111C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7415 c.114C>T synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7436 c.135C>G synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.76 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 7490 c.189C>T synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7496 c.195C>T synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7499 c.198G>T synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7694 c.393A>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7706 c.405C>G synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7797 c.496_498delCTAinsTTG synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 7802 c.501C>G synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 7814 c.513C>G synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7886 c.585T>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8843 c.1542G>A synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8846 c.1545C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8858 c.1557T>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8952 p.Gln551Ala missense_variant 0.67 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.63 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.63 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>T synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9044 c.1743C>T synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.54 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9324 c.2023_2025delTCGinsAGT synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>T synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>T synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9362 c.2061C>T synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9377 c.2076A>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.46 levofloxacin
moxifloxacin
fgd1 491598 c.816C>T synonymous_variant 0.67 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491601 c.819T>C synonymous_variant 0.67 pretomanid
delamanid
clofazimine
fgd1 491604 c.822G>C synonymous_variant 0.67 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.64 pretomanid
delamanid
clofazimine
ccsA 620319 c.429C>T synonymous_variant 0.75 kanamycin
capreomycin
amikacin
ccsA 620332 c.442C>T synonymous_variant 0.69 kanamycin
capreomycin
amikacin
ccsA 620335 c.445_447delCTCinsTTG synonymous_variant 0.69 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.69 kanamycin
capreomycin
amikacin
ccsA 620349 c.459A>G synonymous_variant 0.69 kanamycin
capreomycin
amikacin
ccsA 620358 c.468C>G synonymous_variant 0.69 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Ser missense_variant 0.69 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.69 kanamycin
capreomycin
amikacin
ccsA 620370 c.480C>G synonymous_variant 0.75 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>T synonymous_variant 0.77 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>C synonymous_variant 0.83 kanamycin
capreomycin
amikacin
ccsA 620625 c.735A>C synonymous_variant 0.75 kanamycin
capreomycin
amikacin
ccsA 620631 c.741T>C synonymous_variant 0.8 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.79 kanamycin
capreomycin
amikacin
ccsA 620676 c.786C>T synonymous_variant 0.78 kanamycin
capreomycin
amikacin
ccsA 620694 c.804C>G synonymous_variant 0.79 kanamycin
capreomycin
amikacin
ccsA 620698 p.Val270Ile missense_variant 0.78 kanamycin
capreomycin
amikacin
ccsA 620724 c.834C>T synonymous_variant 0.74 kanamycin
capreomycin
amikacin
ccsA 620730 c.840C>T synonymous_variant 0.72 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.76 kanamycin
capreomycin
amikacin
ccsA 620736 c.846G>T synonymous_variant 0.71 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.76 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.76 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>T synonymous_variant 0.8 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>C synonymous_variant 0.92 kanamycin
capreomycin
amikacin
ccsA 620766 c.876C>G synonymous_variant 0.85 kanamycin
capreomycin
amikacin
nusG 734421 c.168A>C synonymous_variant 0.61 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.62 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.67 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.66 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.63 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.63 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.63 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.73 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.64 rifampicin
mmaA3 738135 c.15A>G synonymous_variant 1.0 isoniazid
rpoB 760070 c.264T>G synonymous_variant 0.7 rifampicin
rpoB 760082 c.276C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760088 c.282C>G synonymous_variant 0.67 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760104 c.298_300delTCGinsAGC synonymous_variant 0.67 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.8 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.8 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.83 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.83 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.81 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.82 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.8 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.85 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.83 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.84 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.86 rifampicin Uncertain significance
rpoB 760424 c.618C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.64 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.91 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.79 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.79 rifampicin
rpoB 760755 p.His317Asn missense_variant 0.79 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.79 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.79 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.8 rifampicin
rpoB 760784 c.978G>C synonymous_variant 0.94 rifampicin
rpoB 760787 c.981G>C synonymous_variant 0.94 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.94 rifampicin
rpoB 760805 c.999G>C synonymous_variant 1.0 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 1.0 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.9 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.8 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.76 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.76 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.73 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.73 rifampicin Uncertain significance
rpoB 760916 c.1110C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.7 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.78 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.82 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.82 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.8 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.69 rifampicin
rpoB 760985 c.1179G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.73 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.75 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.82 rifampicin
rpoB 761346 p.Val514Ile missense_variant 0.83 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.82 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.73 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.81 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.89 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.79 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.8 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.83 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.83 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.82 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.82 rifampicin
rpoB 761702 c.1896C>A synonymous_variant 0.82 rifampicin
rpoB 761718 p.Ala638Ser missense_variant 0.77 rifampicin
rpoB 761723 p.GluSer640LysAla missense_variant 0.77 rifampicin
rpoB 761736 p.Ile644Val missense_variant 0.79 rifampicin Uncertain significance
rpoB 761747 c.1941G>C synonymous_variant 0.8 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.73 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.91 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.77 rifampicin
rpoB 761783 c.1977C>T synonymous_variant 0.83 rifampicin
rpoB 761784 p.Thr660Ser missense_variant 0.83 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.83 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.79 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.83 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.73 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.73 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.73 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.67 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.67 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.67 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.67 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.67 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.69 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.83 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.84 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.83 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.84 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.76 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.77 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.77 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.9 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.89 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.86 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 0.86 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.84 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.71 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.75 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.58 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.58 rifampicin
rpoB 762833 c.3027C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 0.8 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762878 p.Ile1024Met missense_variant 0.79 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.79 rifampicin Uncertain significance
rpoB 762929 c.3123G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.97 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 763109 c.-261C>G upstream_gene_variant 0.81 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.7 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.77 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.8 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.75 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.7 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.68 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.7 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 0.67 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.58 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.56 rifampicin
rpoC 763232 c.-138C>T upstream_gene_variant 0.62 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.65 rifampicin
rpoB 763241 p.Glu1145Asp missense_variant 0.59 rifampicin
rpoC 763262 c.-108C>T upstream_gene_variant 0.69 rifampicin
rpoC 763265 c.-105G>C upstream_gene_variant 0.69 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763289 c.-81C>G upstream_gene_variant 0.58 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.44 rifampicin
rpoC 763417 c.48C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763423 p.Glu18Asp missense_variant 0.44 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCGC synonymous_variant 0.44 rifampicin
rpoC 763433 p.Gln22Asn missense_variant 0.44 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.53 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.53 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.81 rifampicin
rpoC 763484 c.115_117delCTTinsTTG synonymous_variant 0.81 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.89 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>T synonymous_variant 0.9 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.85 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.76 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.74 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.76 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.83 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.82 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.74 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.78 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.85 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.86 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.9 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.9 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.89 rifampicin
rpoC 763852 c.483C>A synonymous_variant 0.94 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.95 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.95 rifampicin
rpoC 763871 p.Gly168Ser missense_variant 0.94 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.94 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.94 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.94 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.94 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.94 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.94 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.92 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.91 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.9 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.81 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.8 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.81 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.87 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.83 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.85 rifampicin
rpoC 764344 c.975C>T synonymous_variant 1.0 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.69 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.69 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.69 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.72 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.73 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.71 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.67 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.67 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.64 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.93 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.68 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.65 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.63 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.59 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.65 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765379 c.2010G>T synonymous_variant 0.7 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.55 rifampicin Uncertain significance
rpoC 765403 c.2034G>C synonymous_variant 0.5 rifampicin
rpoC 765404 p.Leu679Lys missense_variant 0.55 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.58 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.5 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.54 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.5 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.54 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.5 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.5 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.43 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.5 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.47 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.53 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765919 c.2550C>T synonymous_variant 0.44 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.5 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.47 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.47 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.47 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.53 rifampicin
rpoC 766741 c.3372G>T synonymous_variant 0.62 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 766798 c.3429C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.85 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766876 c.3507C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.83 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.83 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.83 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.71 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.73 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.69 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.69 rifampicin
rpoC 766931 p.Ala1188Thr missense_variant 0.71 rifampicin Uncertain significance
rpoC 766996 c.3627C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 767068 c.3699G>C synonymous_variant 0.8 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 0.71 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.55 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.55 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.59 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.62 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
mmpL5 776081 c.2400G>C synonymous_variant 0.7 bedaquiline
clofazimine
mmpL5 776084 c.2397C>G synonymous_variant 0.8 bedaquiline
clofazimine
mmpL5 776087 p.Val798Met missense_variant 0.8 bedaquiline
clofazimine
mmpL5 776096 c.2385C>G synonymous_variant 0.8 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Leu missense_variant 0.8 bedaquiline
clofazimine
mmpL5 776107 c.2374C>T synonymous_variant 0.7 bedaquiline
clofazimine
rpsL 781605 p.Ile16Val missense_variant 0.7 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.7 streptomycin
rpsL 781631 c.72G>C synonymous_variant 0.83 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.85 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.83 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.82 streptomycin
rpsL 781664 c.105C>G synonymous_variant 0.82 streptomycin
rpsL 781667 c.108C>T synonymous_variant 0.83 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.77 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.74 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.74 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.72 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.69 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.69 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.67 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.67 streptomycin
rpsL 781737 p.Gln60Gly missense_variant 0.67 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.67 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.76 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.8 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.81 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.86 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.86 streptomycin Not assoc w R - Interim
rpsL 781793 c.234G>C synonymous_variant 0.87 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.93 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.93 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.9 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.96 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.96 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.96 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.97 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.97 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.97 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.97 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.97 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.97 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.97 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.96 streptomycin
rpsL 781916 c.357T>C synonymous_variant 1.0 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 1.0 streptomycin Uncertain significance
rplC 800642 c.-167C>T upstream_gene_variant 0.63 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.61 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.65 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.68 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.61 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.58 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.61 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.61 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.67 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.75 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.75 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.73 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.69 linezolid
fbiC 1304546 p.Val539Ala missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304562 c.1632G>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304571 c.1641G>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.9 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.94 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.93 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.93 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.92 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.7 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>T synonymous_variant 0.71 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304715 c.1785G>T synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fbiC 1304727 c.1797A>C synonymous_variant 0.74 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.69 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.69 pretomanid
delamanid
clofazimine
fbiC 1304760 c.1830G>C synonymous_variant 0.69 pretomanid
delamanid
clofazimine
fbiC 1304769 c.1839C>G synonymous_variant 0.75 pretomanid
delamanid
clofazimine
fbiC 1304775 c.1845C>G synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>G synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>G synonymous_variant 0.73 pretomanid
delamanid
clofazimine
sigE 1364778 c.366G>C synonymous_variant 0.5 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.6 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.69 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.75 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.67 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.71 pyrazinamide
sigE 1364818 c.406_408delCTAinsTTG synonymous_variant 0.71 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.7 pyrazinamide
sigE 1364859 c.447C>T synonymous_variant 0.74 pyrazinamide
sigE 1364862 c.450C>T synonymous_variant 0.74 pyrazinamide
sigE 1364865 c.453G>T synonymous_variant 0.74 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.74 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.74 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.74 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.64 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.69 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.69 pyrazinamide
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.77 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
inhA 1673901 c.-301A>G upstream_gene_variant 0.64 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.7 isoniazid
ethionamide
inhA 1673916 c.-286A>T upstream_gene_variant 0.64 isoniazid
ethionamide
inhA 1673917 c.-285G>T upstream_gene_variant 0.64 isoniazid Uncertain significance
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.58 isoniazid
ethionamide
inhA 1674471 c.270G>C synonymous_variant 0.76 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.76 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.76 isoniazid
ethionamide
inhA 1674489 c.288G>T synonymous_variant 0.76 isoniazid
ethionamide
inhA 1674503 p.Thr101Ser missense_variant 0.73 isoniazid
ethionamide
inhA 1674507 c.306G>T synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674513 c.312C>T synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674514 p.Ile105Val missense_variant 0.73 isoniazid
ethionamide
inhA 1674522 c.321G>C synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674531 c.330C>T synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674534 c.333G>T synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.75 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.67 isoniazid
ethionamide
inhA 1674550 p.Ser117Ala missense_variant 0.64 isoniazid
ethionamide
inhA 1674573 c.372G>C synonymous_variant 0.8 isoniazid
ethionamide
inhA 1674576 c.375T>C synonymous_variant 0.67 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.67 isoniazid
ethionamide
inhA 1674585 c.384T>G synonymous_variant 0.67 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674589 p.Met130Leu missense_variant 0.67 isoniazid
ethionamide
inhA 1674600 c.399G>C synonymous_variant 0.58 isoniazid
ethionamide
inhA 1674669 c.468G>T synonymous_variant 0.54 isoniazid
ethionamide
rpsA 1833554 p.Thr5Ser missense_variant 0.4 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.52 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.52 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.52 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.67 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.7 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.77 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.77 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.88 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.88 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.86 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.86 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.87 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.86 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.86 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.87 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.88 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.88 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.88 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.88 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.88 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.92 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.96 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.96 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.96 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.96 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.96 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.97 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.96 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.93 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.93 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.94 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.94 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.9 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.89 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.85 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.88 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.78 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.72 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.71 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.69 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.69 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.71 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.76 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.62 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.62 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.68 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.68 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.81 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>C synonymous_variant 0.84 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.85 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834252 c.711C>T synonymous_variant 0.94 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.94 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.9 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.94 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.9 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.94 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.96 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.86 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.91 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.85 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.81 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.71 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.78 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.69 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.69 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.65 pyrazinamide Uncertain significance
rpsA 1834591 c.1050C>T synonymous_variant 0.79 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.81 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.84 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.74 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.73 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.78 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.83 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.78 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.78 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.77 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.73 pyrazinamide
rpsA 1834774 c.1233C>G synonymous_variant 0.65 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.65 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.71 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.71 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.71 pyrazinamide
katG 2155637 p.Leu159Ile missense_variant 0.6 isoniazid
katG 2155659 p.Val151Leu missense_variant 0.6 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.7 isoniazid
kasA 2517917 c.-198G>T upstream_gene_variant 0.86 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.81 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.77 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.73 isoniazid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3065055 c.1137T>G synonymous_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065058 c.1134C>G synonymous_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065061 c.1131C>T synonymous_variant 0.8 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065064 c.1128G>C synonymous_variant 0.82 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065085 c.1105_1107delAGGinsCGC synonymous_variant 0.67 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065088 c.1104A>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065097 c.1095C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065106 c.1086C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065111 c.1081A>C synonymous_variant 0.67 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyA 3073953 c.519T>C synonymous_variant 0.69 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.69 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.69 para-aminosalicylic_acid
lpqB 3625615 c.-705G>A upstream_gene_variant 0.77 rifampicin
bedaquiline
mtrB 3625623 p.Thr331Ala missense_variant 0.77 rifampicin
bedaquiline
mtrB 3625633 c.981C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625636 p.Ala326Glu missense_variant 0.77 rifampicin
bedaquiline
lpqB 3625639 c.-729C>T upstream_gene_variant 0.77 rifampicin
bedaquiline
mtrB 3625648 p.Tyr322His missense_variant 0.69 rifampicin
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625657 c.-747C>T upstream_gene_variant 0.73 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.69 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.69 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.64 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625741 c.-831G>A upstream_gene_variant 0.55 rifampicin
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625753 p.Ala287Gln missense_variant 0.55 rifampicin
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.58 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.64 rifampicin
bedaquiline
rpoA 3877587 c.921A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3877590 c.918G>C synonymous_variant 0.86 rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.88 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.9 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.89 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.88 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.86 rifampicin
rpoA 3877803 c.705G>C synonymous_variant 0.84 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.93 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>T synonymous_variant 0.97 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.88 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.62 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.71 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.76 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.81 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.68 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3878232 c.276G>C synonymous_variant 0.67 rifampicin
rpoA 3878238 c.270C>T synonymous_variant 0.55 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.55 rifampicin
rpoA 3878247 c.261G>T synonymous_variant 0.61 rifampicin
clpC1 4038410 c.2295C>T synonymous_variant 0.69 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.69 pyrazinamide
clpC1 4038428 c.2277G>C synonymous_variant 0.69 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.69 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.67 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.67 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.69 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.71 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 0.82 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.86 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.85 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.89 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.95 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.83 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 0.79 pyrazinamide
clpC1 4038536 c.2169C>G synonymous_variant 0.8 pyrazinamide
clpC1 4038551 c.2154C>G synonymous_variant 0.71 pyrazinamide
clpC1 4038563 c.2142C>T synonymous_variant 0.59 pyrazinamide
clpC1 4038584 c.2121G>T synonymous_variant 0.56 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.56 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.56 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.75 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.75 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.75 pyrazinamide
clpC1 4038770 c.1935C>A synonymous_variant 0.75 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.8 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.81 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.82 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.87 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.88 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.87 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.77 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.68 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.67 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.65 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.68 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.7 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.72 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.76 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.75 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.72 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.72 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.73 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.9 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.88 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.88 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.87 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.81 pyrazinamide
clpC1 4039124 c.1581C>T synonymous_variant 0.81 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.86 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.88 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.86 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.84 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.86 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.86 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039265 c.1440C>T synonymous_variant 0.8 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>T synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.83 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.73 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.7 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.7 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.73 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.83 pyrazinamide
clpC1 4039454 c.1251A>C synonymous_variant 1.0 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.81 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.71 pyrazinamide Uncertain significance
clpC1 4039574 c.1131G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039575 p.Ala377Gly missense_variant 0.67 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039616 c.1089G>T synonymous_variant 0.62 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.65 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.6 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.5 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.54 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.75 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.86 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.88 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4039925 c.780C>T synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.8 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.81 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.8 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.84 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.81 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.86 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 0.92 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.92 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.92 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.92 pyrazinamide
clpC1 4040195 c.510G>C synonymous_variant 0.91 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.91 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.9 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.9 pyrazinamide
clpC1 4040213 p.Ser164Asn missense_variant 0.9 pyrazinamide
clpC1 4040219 c.486C>G synonymous_variant 0.9 pyrazinamide
clpC1 4040225 c.480A>T synonymous_variant 0.83 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.83 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.77 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.77 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 0.86 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4040306 c.399G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 0.93 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.94 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.88 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.76 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.75 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.73 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.73 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.69 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.73 pyrazinamide
clpC1 4040594 c.111G>T synonymous_variant 0.73 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.73 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.73 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.73 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.75 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.78 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.81 pyrazinamide
clpC1 4040648 c.57G>A synonymous_variant 0.79 pyrazinamide
glpK 4138696 p.Pro354Thr missense_variant 0.79 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4138703 c.1051_1053delCGCinsAGG synonymous_variant 0.79 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.79 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>T synonymous_variant 0.85 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138727 c.1029C>G synonymous_variant 0.85 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138730 c.1026C>T synonymous_variant 0.85 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139408 c.348T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240783 c.921G>C synonymous_variant 0.75 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.71 ethambutol
embC 4240819 c.957A>T synonymous_variant 0.65 ethambutol
embC 4240825 c.963G>A synonymous_variant 0.62 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.59 ethambutol
embC 4241545 c.1683T>C synonymous_variant 0.53 ethambutol
embC 4241548 c.1686T>A synonymous_variant 0.53 ethambutol
embC 4241551 c.1689A>C synonymous_variant 0.53 ethambutol
embC 4241560 c.1698C>G synonymous_variant 0.53 ethambutol
embC 4241572 c.1710C>T synonymous_variant 0.44 ethambutol Not assoc w R
embC 4241584 c.1722T>C synonymous_variant 0.53 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.57 ethambutol
embC 4241591 c.1729_1731delCTCinsTTG synonymous_variant 0.57 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.62 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.5 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.5 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>A synonymous_variant 0.5 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.57 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.67 ethambutol
embB 4247476 c.963C>T synonymous_variant 0.67 ethambutol
embB 4247488 c.975C>T synonymous_variant 0.62 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.62 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.67 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.69 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.67 ethambutol
embB 4247524 c.1011G>C synonymous_variant 0.67 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.64 ethambutol