TB-Profiler result

Run: SRR3675222
Summary

Run ID: SRR3675222

Sample name:

Date: 2024-04-14T19:55:35.981166

Number of reads: 410155

Percentage reads mapped: 22.06

Median coverage: 6.0

Strain: La1.7

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.7 M.bovis None 0.05
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.190G>A Mutation from literature
n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472035 n.190G>A non_coding_transcript_exon_variant 0.69 streptomycin Mutation from literature
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 615 c.615C>T synonymous_variant 0.62 isoniazid
dnaA 633 c.633T>C synonymous_variant 0.62 isoniazid
dnaA 636 c.636C>G synonymous_variant 0.62 isoniazid
gyrB 6680 c.1441C>T synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6685 c.1446C>T synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.83 levofloxacin
moxifloxacin
gyrB 6802 c.1563G>A synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7406 c.105G>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7427 c.126G>A synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7430 c.129G>A synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7475 c.174A>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.83 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7485 c.184_185delTCinsAG synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7490 c.189C>T synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7502 c.201C>T synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.71 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7847 c.546G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7853 c.552C>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.92 levofloxacin
moxifloxacin
gyrA 7942 p.Glu214Ala missense_variant 0.92 levofloxacin
moxifloxacin
gyrA 7946 c.645C>G synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7963 p.Gly221Glu missense_variant 0.77 levofloxacin
moxifloxacin
gyrA 7970 c.669T>C synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7979 c.678G>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 7988 c.687G>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7992 p.Ala231Ser missense_variant 0.7 levofloxacin
moxifloxacin
gyrA 7997 c.696A>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8184 p.Lys295Arg missense_variant 0.69 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.67 levofloxacin
moxifloxacin
gyrA 8240 c.939C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.67 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>T synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8648 c.1347G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.92 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8684 c.1383G>A synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8708 c.1407G>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8720 c.1419G>A synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8723 c.1422G>T synonymous_variant 0.92 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 8729 c.1428T>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8752 p.Ala484Gly missense_variant 0.92 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.91 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.91 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8774 c.1473C>T synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8783 c.1482G>T synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8792 c.1491G>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8813 c.1512C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8840 c.1539C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8876 c.1575C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.6 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
fgd1 491232 c.450T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491268 c.486C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491316 c.534C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491325 c.543G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491328 c.546C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
ccsA 620331 c.441C>T synonymous_variant 0.9 capreomycin
amikacin
kanamycin
ccsA 620361 c.471C>T synonymous_variant 0.83 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>A synonymous_variant 0.8 capreomycin
amikacin
kanamycin
ccsA 620685 c.795G>A synonymous_variant 0.75 capreomycin Not assoc w R - Interim
amikacin
kanamycin Not assoc w R - Interim
ccsA 620698 p.Val270Ile missense_variant 0.85 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.86 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.86 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.85 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.85 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.85 capreomycin
amikacin
kanamycin
ccsA 620757 c.867C>T synonymous_variant 0.83 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620793 c.903G>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
nusG 734391 c.138C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
nusG 734403 c.150C>T synonymous_variant 0.82 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.84 rifampicin
nusG 734418 c.165C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
nusG 734421 c.168A>G synonymous_variant 0.8 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.82 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.85 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.86 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.86 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>T synonymous_variant 0.86 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
nusG 734553 c.300C>G synonymous_variant 0.82 rifampicin
nusG 734556 c.303C>T synonymous_variant 0.81 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.81 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.9 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.88 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.8 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.71 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.71 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.69 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.75 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.75 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.77 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760643 c.837G>A synonymous_variant 0.8 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.88 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.9 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.91 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.91 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 1.0 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 1.0 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 1.0 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 1.0 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 1.0 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 1.0 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 1.0 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>G synonymous_variant 1.0 rifampicin
rpoB 761195 c.1389G>T synonymous_variant 1.0 rifampicin
rpoB 761201 c.1395G>A synonymous_variant 1.0 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 1.0 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761582 c.1776G>A synonymous_variant 1.0 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.94 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761879 c.2073G>A synonymous_variant 0.9 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.9 rifampicin
rpoB 761894 c.2088C>T synonymous_variant 0.91 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.91 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.9 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.9 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.9 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.9 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.92 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.92 rifampicin
rpoB 761955 c.2149_2151delATCinsGG frameshift_variant&missense_variant 0.94 rifampicin
rpoB 761972 c.2166C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762011 c.2205G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762029 c.2223C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762032 c.2226C>T synonymous_variant 0.88 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.85 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.9 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.79 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.79 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762260 c.2454C>T synonymous_variant 0.7 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.7 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 762956 c.-414G>C upstream_gene_variant 0.89 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762971 c.3165G>A synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>G upstream_gene_variant 0.95 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.9 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.9 rifampicin
rpoC 763373 c.4_6delCTCinsTA frameshift_variant&missense_variant 0.55 rifampicin
rpoC 763402 c.33C>A synonymous_variant 0.58 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763430 c.61_63delAGGinsCT frameshift_variant&missense_variant 0.58 rifampicin
rpoC 763435 c.66A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.8 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>T synonymous_variant 0.83 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 1.0 rifampicin
rpoC 763624 c.255C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763648 c.279C>G synonymous_variant 1.0 rifampicin
rpoC 763660 c.291T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 1.0 rifampicin
rpoC 763702 c.333C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 1.0 rifampicin
rpoC 763714 c.345G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 1.0 rifampicin
rpoC 763735 c.366G>C synonymous_variant 1.0 rifampicin
rpoC 763747 c.378G>A synonymous_variant 1.0 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764302 c.933C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764308 c.939G>C synonymous_variant 0.86 rifampicin
rpoC 764311 c.942C>G synonymous_variant 0.85 rifampicin
rpoC 764326 c.957G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764359 c.990C>T synonymous_variant 0.93 rifampicin
rpoC 764383 c.1014C>G synonymous_variant 1.0 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 1.0 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 1.0 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 1.0 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 1.0 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 1.0 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 1.0 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 1.0 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 1.0 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 1.0 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765409 c.2040T>C synonymous_variant 0.9 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.91 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.91 rifampicin
rpoC 765607 c.2238C>G synonymous_variant 1.0 rifampicin
rpoC 765611 p.His748Ala missense_variant 1.0 rifampicin
rpoC 765619 c.2250G>A synonymous_variant 0.91 rifampicin
rpoC 765625 c.2256C>T synonymous_variant 0.91 rifampicin
rpoC 765631 p.Asp754Glu missense_variant 0.91 rifampicin
rpoC 765676 c.2307G>A synonymous_variant 0.82 rifampicin
rpoC 765688 c.2319G>C synonymous_variant 0.83 rifampicin
rpoC 765694 c.2325G>C synonymous_variant 0.83 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 765796 c.2427C>T synonymous_variant 0.92 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765865 c.2496C>T synonymous_variant 1.0 rifampicin
rpoC 765871 c.2502T>C synonymous_variant 1.0 rifampicin
rpoC 765875 p.Val836Ile missense_variant 1.0 rifampicin Uncertain significance
rpoC 765883 c.2514C>G synonymous_variant 1.0 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 1.0 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.8 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.91 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.92 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.92 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.92 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.9 rifampicin
rpoC 766429 c.3060C>G synonymous_variant 0.9 rifampicin
rpoC 766435 c.3066G>A synonymous_variant 0.9 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.9 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.91 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.91 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.92 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.88 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.88 rifampicin
rpoC 766495 c.3126C>G synonymous_variant 0.89 rifampicin
rpoC 766522 c.3153C>T synonymous_variant 0.89 rifampicin
rpoC 766525 c.3156G>T synonymous_variant 0.89 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.93 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.9 rifampicin
rpoC 766558 c.3189G>A synonymous_variant 0.86 rifampicin
rpoC 766564 c.3195C>T synonymous_variant 0.88 rifampicin
rpoC 766565 p.Ile1066Val missense_variant 0.88 rifampicin Uncertain significance
rpoC 766573 c.3204T>C synonymous_variant 0.88 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.88 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.69 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.78 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.83 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.76 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.75 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.71 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.71 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.75 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.83 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.83 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766783 c.3414C>T synonymous_variant 0.83 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.77 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.82 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.83 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.82 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.81 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.83 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.88 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 766960 c.3591C>T synonymous_variant 1.0 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 1.0 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 1.0 rifampicin
rpsL 781138 c.-422C>G upstream_gene_variant 0.91 streptomycin
rpsL 781143 c.-417T>C upstream_gene_variant 0.91 streptomycin
rpsL 781155 c.-405G>C upstream_gene_variant 0.91 streptomycin
rpsL 781158 c.-402C>G upstream_gene_variant 0.92 streptomycin
rpsL 781164 c.-396T>C upstream_gene_variant 0.92 streptomycin
rpsL 781173 c.-387A>G upstream_gene_variant 0.92 streptomycin
rpsL 781174 c.-386C>A upstream_gene_variant 0.92 streptomycin
rpsL 781179 c.-381T>C upstream_gene_variant 0.92 streptomycin
rpsL 781185 c.-375T>C upstream_gene_variant 0.92 streptomycin
rpsL 781189 c.-371T>C upstream_gene_variant 0.92 streptomycin
rpsL 781197 c.-363A>G upstream_gene_variant 0.92 streptomycin
rpsL 781209 c.-351C>G upstream_gene_variant 0.92 streptomycin
rpsL 781218 c.-342C>G upstream_gene_variant 0.92 streptomycin
rpsL 781224 c.-336T>C upstream_gene_variant 0.92 streptomycin
rpsL 781245 c.-315C>T upstream_gene_variant 0.91 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.83 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.85 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.83 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.87 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.86 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.86 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.85 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.85 streptomycin Not assoc w R - Interim
rpsL 781778 c.219C>T synonymous_variant 0.85 streptomycin
rpsL 781779 c.220C>T synonymous_variant 0.85 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.89 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.95 streptomycin
rpsL 781865 c.306G>C synonymous_variant 1.0 streptomycin
rpsL 781868 c.309T>C synonymous_variant 1.0 streptomycin
rpsL 781871 c.312G>C synonymous_variant 1.0 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.95 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.95 streptomycin
rpsL 781904 c.345C>T synonymous_variant 0.91 streptomycin Not assoc w R - Interim
rpsL 781907 c.348T>C synonymous_variant 0.91 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.91 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.88 streptomycin Uncertain significance
fbiC 1303695 c.765T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303713 c.783C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303872 c.942C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303908 c.978C>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
sigE 1364721 c.309C>G synonymous_variant 0.73 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.83 pyrazinamide
sigE 1364751 c.339C>G synonymous_variant 0.87 pyrazinamide
sigE 1364760 c.348C>G synonymous_variant 0.82 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.82 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.88 pyrazinamide
sigE 1364796 c.384G>A synonymous_variant 0.93 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.86 pyrazinamide
sigE 1364805 c.393C>T synonymous_variant 0.88 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.88 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.83 pyrazinamide
sigE 1364832 c.420C>G synonymous_variant 0.82 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.82 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.82 pyrazinamide
atpE 1461062 c.18T>A synonymous_variant 0.67 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.94 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.88 bedaquiline
atpE 1461167 c.123G>C synonymous_variant 0.88 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.88 bedaquiline
atpE 1461179 c.135G>A synonymous_variant 0.82 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.81 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.81 bedaquiline
atpE 1461188 c.144G>T synonymous_variant 0.81 bedaquiline
atpE 1461191 c.147G>C synonymous_variant 0.76 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.76 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 0.73 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.73 bedaquiline
atpE 1461230 c.186G>T synonymous_variant 0.6 bedaquiline
atpE 1461233 c.189A>T synonymous_variant 0.6 bedaquiline
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471984 n.139T>A non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>C non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473290 n.1445delCinsTT non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473606 n.-52C>T upstream_gene_variant 0.6 capreomycin
linezolid
rrl 1473653 n.-5T>A upstream_gene_variant 0.71 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1473814 n.157A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473831 n.174G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1473923 n.266C>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1473980 n.324_327delGGAT non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1473987 n.330_331insATCT non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474007 n.350A>G non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474016 n.359C>A non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474018 n.361G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474029 n.372G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474090 n.433C>T non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474104 n.448delT non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1474111 n.454_455insC non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474127 n.470G>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474412 n.756_768delACCCACACGCGCA non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474428 n.771C>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474431 n.774G>C non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474434 n.777_778insAAGGG non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474437 n.781_782delAA non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474716 n.1059A>C non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1474957 n.1300C>T non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474959 n.1303_1305delCTT non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474965 n.1308_1311delGGTGinsAAGTA non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475007 n.1350C>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475018 n.1361G>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475019 n.1362T>A non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1475337 n.1680C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475404 n.1747A>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.86 capreomycin
linezolid Uncertain significance
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475606 n.1949T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475619 n.1962C>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475622 n.1965G>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475635 n.1978G>A non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>T non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1476040 n.2383C>T non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476046 n.2389G>A non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476710 n.3053C>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476720 n.3063G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
inhA 1673625 c.-577C>G upstream_gene_variant 0.6 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.67 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.6 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.55 ethionamide
isoniazid
inhA 1673934 c.-268C>T upstream_gene_variant 0.8 ethionamide
isoniazid
inhA 1673946 c.-256C>A upstream_gene_variant 0.8 ethionamide
isoniazid
inhA 1673950 c.-252C>T upstream_gene_variant 0.8 ethionamide
isoniazid
fabG1 1673960 p.Ala174Val missense_variant 0.77 ethionamide
isoniazid
inhA 1673982 c.-220G>C upstream_gene_variant 0.77 ethionamide
isoniazid
inhA 1673988 c.-214G>C upstream_gene_variant 0.79 ethionamide
isoniazid
inhA 1673991 c.-211C>T upstream_gene_variant 0.79 ethionamide
isoniazid
inhA 1674015 c.-187C>A upstream_gene_variant 0.86 ethionamide
isoniazid
inhA 1674018 c.-184G>C upstream_gene_variant 0.86 ethionamide
isoniazid
inhA 1674019 c.-183C>T upstream_gene_variant 0.86 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.87 ethionamide
isoniazid
fabG1 1674037 p.Gln200Glu missense_variant 0.87 ethionamide
isoniazid
inhA 1674045 c.-157G>A upstream_gene_variant 0.83 ethionamide
isoniazid
inhA 1674046 c.-156C>T upstream_gene_variant 0.83 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674054 c.-148T>C upstream_gene_variant 0.75 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.64 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.64 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.9 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.93 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674762 c.561T>C synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674789 c.588G>A synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674799 p.Ser200Ala missense_variant 1.0 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674822 c.621C>G synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674828 p.Glu209Asp missense_variant 1.0 ethionamide
isoniazid
inhA 1674834 c.633C>G synonymous_variant 1.0 ethionamide
isoniazid
rpsA 1833589 c.48A>T synonymous_variant 1.0 pyrazinamide
rpsA 1833593 c.52_54delTCTinsAC frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833661 c.120A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 1.0 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 1.0 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 1.0 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 1.0 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834018 c.477C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834030 c.489C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834042 c.501G>A synonymous_variant 1.0 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 1.0 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.92 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.93 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.93 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834474 c.933C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834477 c.936C>A synonymous_variant 1.0 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834499 c.958C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834507 c.966C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.84 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.82 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.81 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.79 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.67 pyrazinamide
ndh 2102610 c.433T>C synonymous_variant 0.6 ethionamide
delamanid
isoniazid
ndh 2102625 p.Ser140Thr missense_variant 0.6 ethionamide
delamanid
isoniazid
kasA 2518636 c.522C>T synonymous_variant 1.0 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.92 isoniazid
kasA 2518765 c.651G>A synonymous_variant 0.91 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.91 isoniazid
Rv2477c 2783332 c.711T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783427 p.Pro206Ala missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 1.0 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783440 c.603T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.92 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783632 c.411C>G synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 p.Glu128Asp missense_variant 0.93 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783665 c.378A>G synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783836 c.207C>G synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783848 c.195C>T synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783854 c.189C>T synonymous_variant 0.92 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783857 c.186C>T synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>T synonymous_variant 0.94 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.93 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783974 c.69C>T synonymous_variant 0.91 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783983 c.60C>T synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065040 c.1152C>G synonymous_variant 0.75 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065051 c.1141C>T synonymous_variant 0.7 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.82 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.82 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625828 c.-918G>C upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.79 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625867 c.747A>G synonymous_variant 0.8 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625912 c.702G>C synonymous_variant 0.81 bedaquiline
rifampicin
mtrB 3625915 c.699G>T synonymous_variant 0.81 bedaquiline
rifampicin
mtrB 3625927 c.687T>C synonymous_variant 0.84 bedaquiline
rifampicin
mtrB 3625936 c.678C>G synonymous_variant 0.84 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625942 c.670_672delGTCinsCT frameshift_variant&missense_variant 0.89 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625945 c.669A>G synonymous_variant 0.88 bedaquiline
rifampicin
mtrB 3625950 c.664C>T synonymous_variant 0.83 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625951 c.663A>G synonymous_variant 0.84 bedaquiline
rifampicin
mtrB 3625956 c.658C>T synonymous_variant 0.85 bedaquiline
rifampicin
mtrB 3625977 p.Gly213Ser missense_variant 0.89 bedaquiline
rifampicin
mtrB 3625978 c.636T>C synonymous_variant 0.89 bedaquiline
rifampicin
mtrB 3625987 c.627G>T synonymous_variant 0.89 bedaquiline
rifampicin
mtrB 3625993 c.621G>C synonymous_variant 0.81 bedaquiline
rifampicin
mtrB 3625999 c.615A>G synonymous_variant 0.77 bedaquiline
rifampicin
mtrB 3626002 c.612G>A synonymous_variant 0.75 bedaquiline
rifampicin
mtrB 3626006 p.Ser203Asn missense_variant 0.75 bedaquiline
rifampicin
mtrB 3626008 c.606G>C synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626017 c.597T>C synonymous_variant 0.77 bedaquiline
rifampicin
mtrB 3626029 c.585A>G synonymous_variant 0.79 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.7 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626744 c.-131G>C upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3626750 c.-137T>C upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.73 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>A upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3626804 c.-191A>C upstream_gene_variant 0.87 bedaquiline
rifampicin
mtrB 3626849 c.-236C>G upstream_gene_variant 0.91 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.92 bedaquiline
rifampicin
mtrB 3626942 c.-329A>C upstream_gene_variant 0.91 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.83 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.9 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.88 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.88 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.88 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.87 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.86 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878055 c.453A>G synonymous_variant 0.82 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.83 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.82 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.82 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.8 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.82 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.82 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.8 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.8 rifampicin
rpoA 3878141 c.365_366delGC frameshift_variant 0.8 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.89 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.91 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.91 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.88 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.86 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>C synonymous_variant 0.88 rifampicin
rpoA 3878334 c.174T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>C synonymous_variant 0.83 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.82 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.82 rifampicin
rpoA 3878406 c.102G>C synonymous_variant 0.81 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.86 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.83 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.8 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.8 rifampicin
rpoA 3878460 c.48C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3878725 c.-218A>G upstream_gene_variant 1.0 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 1.0 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878764 c.-257A>G upstream_gene_variant 1.0 rifampicin
rpoA 3878767 c.-260G>T upstream_gene_variant 1.0 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 1.0 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 1.0 rifampicin
rpoA 3878806 c.-299C>A upstream_gene_variant 1.0 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 1.0 rifampicin
clpC1 4038474 p.Ser744Ala missense_variant 0.91 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.92 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.92 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.92 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.92 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.9 pyrazinamide
clpC1 4038521 c.2184C>T synonymous_variant 0.9 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.9 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.9 pyrazinamide
clpC1 4038536 c.2169C>G synonymous_variant 0.9 pyrazinamide
clpC1 4038569 c.2136C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.9 pyrazinamide
clpC1 4038695 c.2010C>A synonymous_variant 0.82 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.82 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.85 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.83 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.83 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4039409 c.1296T>C synonymous_variant 0.9 pyrazinamide
clpC1 4039412 c.1293T>A synonymous_variant 0.9 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.9 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.9 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039552 c.1153C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039556 c.1149G>A synonymous_variant 1.0 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 1.0 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 1.0 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.9 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.87 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.87 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.87 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039985 c.720G>A synonymous_variant 0.87 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.89 pyrazinamide
clpC1 4040015 c.690G>T synonymous_variant 0.89 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.89 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.89 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4040408 c.297C>T synonymous_variant 0.92 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4040419 c.286C>T synonymous_variant 0.92 pyrazinamide
clpC1 4040420 c.285G>C synonymous_variant 0.92 pyrazinamide
glpK 4138429 c.1327T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138451 c.1305T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138457 c.1299C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138460 c.1296C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138463 c.1293C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138490 c.1264_1266delGTGinsAC frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138495 p.Gln421Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138532 c.1224G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138592 c.1164C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138598 c.1158G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138619 c.1137C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138661 c.1095T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138681 p.Met359Val missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138726 p.Ala344Ser missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138754 c.1002C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138775 c.981C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138793 c.963T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138799 c.957T>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138811 c.945C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embA 4245101 c.1869G>C synonymous_variant 0.64 ethambutol
embA 4245128 c.1896G>C synonymous_variant 0.73 ethambutol
embA 4245131 c.1899G>C synonymous_variant 0.73 ethambutol Not assoc w R - Interim
embA 4245137 c.1905T>C synonymous_variant 0.77 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.83 ethambutol
embA 4245167 c.1935G>C synonymous_variant 0.85 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.92 ethambutol
embA 4245206 c.1974A>C synonymous_variant 0.8 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.8 ethambutol
embA 4245212 c.1980G>C synonymous_variant 0.8 ethambutol
embA 4245214 p.Ala661Gly missense_variant 0.73 ethambutol
embA 4245224 c.1992T>C synonymous_variant 0.69 ethambutol
embA 4245248 c.2016G>A synonymous_variant 0.58 ethambutol Not assoc w R - Interim
embB 4247497 c.984T>C synonymous_variant 0.67 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.67 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.7 ethambutol
embB 4247527 c.1014G>A synonymous_variant 0.75 ethambutol
embB 4247530 c.1017G>C synonymous_variant 0.75 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.82 ethambutol
embB 4247611 c.1098G>C synonymous_variant 1.0 ethambutol
embB 4248185 c.1672T>C synonymous_variant 0.65 ethambutol
embB 4248190 c.1677G>C synonymous_variant 0.65 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.65 ethambutol
embB 4248200 c.1687_1689delATTinsGG frameshift_variant&missense_variant 0.65 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.65 ethambutol
embB 4248214 c.1701C>G synonymous_variant 0.65 ethambutol
embB 4248220 c.1707A>T synonymous_variant 0.69 ethambutol
embB 4249276 c.2763A>C synonymous_variant 0.91 ethambutol
embB 4249282 c.2769A>C synonymous_variant 0.91 ethambutol
embB 4249321 c.2808A>G synonymous_variant 0.91 ethambutol
embB 4249323 p.Ala937Asp missense_variant 0.83 ethambutol
embB 4249339 c.2826T>C synonymous_variant 0.73 ethambutol
embB 4249369 c.2856T>C synonymous_variant 0.82 ethambutol
embB 4249376 c.2863C>T synonymous_variant 0.83 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.81 ethambutol
embB 4249396 c.2883C>T synonymous_variant 0.79 ethambutol
embB 4249405 c.2892C>G synonymous_variant 0.77 ethambutol
aftB 4268404 p.Leu145Met missense_variant 1.0 ethambutol
aftB 4268429 c.408C>G synonymous_variant 0.8 ethambutol