TB-Profiler result

Run: ERR4817060
Summary

Run ID: ERR4817060

Sample name:

Date: 2024-05-22T19:03:23.892695

Number of reads: 866769

Percentage reads mapped: 36.92

Median coverage: 19.0

Strain:

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.888G>A Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.604_606delTCGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.36 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303534 c.604_606delTCGinsGC frameshift_variant&missense_variant 0.41 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.29 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.41 isoniazid
dnaA 42 c.42C>T synonymous_variant 0.5 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.35 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 897 c.897A>G synonymous_variant 0.33 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.33 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.37 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.35 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.35 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.3 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.37 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.33 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.39 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.38 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.44 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.43 isoniazid
dnaA 1461 c.1461C>G synonymous_variant 0.5 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.47 isoniazid
dnaA 1485 c.1485A>G synonymous_variant 0.47 isoniazid
dnaA 1488 c.1488A>G synonymous_variant 0.47 isoniazid
gyrB 6280 c.1041T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>A upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.67 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.59 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7216 c.1977G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7324 c.23_24insAGG disruptive_inframe_insertion 0.43 levofloxacin
moxifloxacin
gyrA 7334 c.33G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7335 p.Leu12Val missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 7347 c.46_48delGAAinsCG frameshift_variant&missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7477 p.Met59Thr missense_variant 0.65 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.67 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.61 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.61 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.59 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8401 p.Asp367Ala missense_variant 0.61 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.43 levofloxacin Uncertain significance
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.32 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 0.38 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
Rv0010c 13788 c.-230C>G upstream_gene_variant 0.94 isoniazid
fgd1 490812 c.30A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.39 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491173 c.391C>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
mshA 575812 c.465C>T synonymous_variant 0.42 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.4 ethionamide
isoniazid Not assoc w R - Interim
mshA 575884 c.537G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.34 ethionamide
isoniazid
ccsA 619543 c.-348C>G upstream_gene_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>T upstream_gene_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620284 c.394_396delGCGinsCC frameshift_variant&missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>T synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.3 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
Rv0565c 656265 c.1204_1205delAC frameshift_variant 1.0 ethionamide Uncertain significance
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.33 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.36 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.35 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.36 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.39 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.33 ethionamide
Rv0565c 656487 c.984T>C synonymous_variant 0.33 ethionamide Not assoc w R - Interim
Rv0565c 656493 c.978C>G synonymous_variant 0.33 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.69 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.52 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.47 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.53 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.53 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.4 ethionamide
hadA 732295 c.366G>C synonymous_variant 0.47 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.5 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.5 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.52 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.52 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.53 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.53 isoniazid
nusG 734370 c.117A>G synonymous_variant 0.4 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.38 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.5 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.56 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.65 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.59 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.56 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.53 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.55 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.64 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.62 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.53 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.5 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.67 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760340 c.534G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.58 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.54 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.58 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.64 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.69 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.6 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.54 rifampicin Uncertain significance
rpoB 760611 c.805T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.7 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.47 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.44 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.44 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.52 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.45 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.38 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.44 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.5 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.39 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.36 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.41 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.5 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.41 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.41 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.43 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.43 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.48 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.24 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.24 rifampicin
rpoB 761792 c.1986T>C synonymous_variant 0.22 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.33 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.42 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.35 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.35 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.4 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.4 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.4 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.55 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762032 c.2226C>T synonymous_variant 0.53 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.45 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.35 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.42 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.46 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762799 p.Ala998Gly missense_variant 0.47 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.47 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.47 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 762926 c.-444C>G upstream_gene_variant 0.26 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762938 c.-432G>C upstream_gene_variant 0.26 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.19 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.72 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.48 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.6 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.5 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.6 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.46 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.5 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.5 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.55 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.3 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763622 p.Ala85Ser missense_variant 0.21 rifampicin Uncertain significance
rpoC 763636 c.267T>C synonymous_variant 0.59 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.32 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.44 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763718 p.Leu117Val missense_variant 0.39 rifampicin
rpoC 763723 c.354G>C synonymous_variant 0.64 rifampicin
rpoC 763724 p.Asp119Asn missense_variant 0.39 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.38 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.61 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.42 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.59 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.47 rifampicin
rpoC 763772 c.403_405delGTGinsAC frameshift_variant&missense_variant 0.37 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.5 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.52 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.64 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.54 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.53 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764236 c.867G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.32 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.39 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.39 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.39 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.47 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141_1143delCTGinsTC frameshift_variant&missense_variant 0.31 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.82 rifampicin
rpoC 764543 c.1174_1176delACCinsGG frameshift_variant&missense_variant 0.5 rifampicin
rpoC 764548 c.1179G>C synonymous_variant 0.48 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.3 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsAC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.46 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.68 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.46 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.7 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.34 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.39 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.41 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.5 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.59 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.56 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.5 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.37 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.42 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765292 c.1923G>C synonymous_variant 0.36 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.32 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.31 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.32 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.33 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.38 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.48 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.54 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.45 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.45 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.44 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.44 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.43 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.43 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.36 rifampicin
rpoC 765850 c.2481G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.56 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.44 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.62 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.62 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.52 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.46 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.42 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.41 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.23 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.58 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.54 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.58 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.53 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.61 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.67 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.55 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.58 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.59 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.52 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.5 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.52 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.52 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.48 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.5 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.5 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.44 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.44 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.5 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.44 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.36 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.38 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.38 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.5 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.52 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.56 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.64 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.52 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766885 c.3516G>A synonymous_variant 0.45 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.33 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.37 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.39 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.34 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.32 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.35 rifampicin
rpoC 767275 c.3906T>C synonymous_variant 0.35 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.35 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.33 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.47 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.42 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.44 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.46 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.48 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.54 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.54 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.48 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.47 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.38 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.4 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.43 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.43 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.48 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.45 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.48 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.44 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.6 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.48 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.35 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.41 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.29 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.33 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.36 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.37 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.38 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.32 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.38 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.32 streptomycin Uncertain significance
rplC 800612 c.-197A>G upstream_gene_variant 0.42 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.48 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.52 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.53 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.62 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.76 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.62 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.57 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.59 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.59 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.52 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.4 linezolid
rplC 800814 c.6A>G synonymous_variant 0.33 linezolid
rplC 800817 c.9A>T synonymous_variant 0.33 linezolid
rplC 801300 c.492C>G synonymous_variant 0.25 linezolid
rplC 801309 c.501C>G synonymous_variant 0.26 linezolid
rplC 801312 c.504G>C synonymous_variant 0.27 linezolid
rplC 801321 c.513C>T synonymous_variant 0.26 linezolid Not assoc w R - Interim
rplC 801348 c.540T>G synonymous_variant 0.25 linezolid
rplC 801357 c.549T>C synonymous_variant 0.26 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.34 linezolid
rplC 801402 c.594T>C synonymous_variant 0.29 linezolid
rplC 801405 c.597T>C synonymous_variant 0.29 linezolid
rplC 801438 c.630T>C synonymous_variant 0.25 linezolid
rplC 801442 p.Ile212Val missense_variant 0.27 linezolid
fbiC 1303501 c.571C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303842 c.912C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303866 p.Glu312Asp missense_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303867 p.Asp313Asn missense_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.55 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1305384 c.2454G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305396 c.2466C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.37 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305417 c.2487C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305423 c.2493T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305430 p.Val834Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305444 c.2514A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
atpE 1461170 c.126A>G synonymous_variant 0.65 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.63 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.65 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.59 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.48 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.92 streptomycin Not assoc w R
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443_1449delCTCGGGAinsGGCTTGTCCGGG non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473822 n.165delAinsTG non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474393 n.736A>G non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474448 n.791T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474545 n.888G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474634 n.977T>G non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474658 n.1001A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096_1097delACinsG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1475754 n.2097G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475760 n.2103_2107delCCGCAinsACCCCCCG non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475767 n.2110_2111insT non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475774 n.2117C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.7 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476600 n.2943A>C non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476633 n.2976A>G non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
fabG1 1673941 p.Ala168Ser missense_variant 0.56 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.56 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.5 ethionamide
isoniazid
fabG1 1673962 p.Asn175Gly missense_variant 0.5 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.48 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.54 ethionamide
isoniazid
inhA 1674012 c.-190C>T upstream_gene_variant 0.55 ethionamide
isoniazid
inhA 1674018 c.-184G>T upstream_gene_variant 0.55 ethionamide
isoniazid
inhA 1674504 c.303C>G synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.76 ethionamide
isoniazid
inhA 1674514 p.Ile105Val missense_variant 0.83 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.81 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.81 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.75 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.64 ethionamide
isoniazid
inhA 1674601 p.Leu134Ala missense_variant 0.53 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.46 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674732 c.531C>T synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674816 c.615T>G synonymous_variant 0.7 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.58 ethionamide
isoniazid
inhA 1674864 c.663C>T synonymous_variant 0.48 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.46 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.44 ethionamide
isoniazid
rpsA 1833589 c.48A>T synonymous_variant 0.61 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.63 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.63 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.57 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.5 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.47 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.44 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.43 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.47 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.5 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.52 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.67 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.39 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834307 c.766_768delGACinsCG frameshift_variant&missense_variant 0.27 pyrazinamide Uncertain significance
rpsA 1834312 c.771G>A synonymous_variant 0.26 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.65 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.69 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.64 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.33 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.55 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.41 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.45 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.5 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.52 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.52 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.52 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.46 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.44 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.5 linezolid
tlyA 1917951 c.12T>C synonymous_variant 0.5 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.61 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.58 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.48 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.47 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>G synonymous_variant 0.48 capreomycin
tlyA 1918002 c.63A>G synonymous_variant 0.47 capreomycin
tlyA 1918036 p.Arg33Ser missense_variant 0.35 capreomycin
bacA 2064933 c.-205A>G upstream_gene_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
katG 2155641 p.Lys157Asn missense_variant 0.44 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 0.43 isoniazid
katG 2155677 c.435C>G synonymous_variant 0.48 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.48 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.48 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.48 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.52 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.48 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.48 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.43 isoniazid
PPE35 2168149 p.Pro822Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289925 c.-684T>C upstream_gene_variant 0.7 pyrazinamide
pncA 2289930 c.-689A>G upstream_gene_variant 0.75 pyrazinamide
pncA 2289943 c.-702T>G upstream_gene_variant 0.64 pyrazinamide
pncA 2289948 c.-707C>T upstream_gene_variant 0.6 pyrazinamide
pncA 2289949 c.-708A>G upstream_gene_variant 0.6 pyrazinamide
pncA 2289987 c.-746C>T upstream_gene_variant 0.62 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.62 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.62 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.67 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.59 pyrazinamide
pncA 2290015 c.-774A>C upstream_gene_variant 0.52 pyrazinamide
pncA 2290024 c.-783C>G upstream_gene_variant 0.42 pyrazinamide
pncA 2290030 c.-791_-789delAATinsCC upstream_gene_variant 0.39 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.48 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.5 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.47 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.42 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.42 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.38 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.38 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.38 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.38 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.4 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.4 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.4 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.44 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.4 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.35 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.38 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.39 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.37 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.35 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.35 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.37 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.38 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.42 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.43 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.3 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.3 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.29 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.26 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.21 isoniazid
kasA 2518993 c.879C>G synonymous_variant 0.2 isoniazid
kasA 2518999 c.885G>A synonymous_variant 0.22 isoniazid
kasA 2519021 p.Ala303Lys missense_variant 0.23 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.38 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.39 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.53 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.5 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.48 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.48 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.56 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.63 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.64 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.57 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.57 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.6 isoniazid
ahpC 2726303 c.111T>C synonymous_variant 0.27 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.57 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.6 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.58 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.6 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.6 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.6 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.65 isoniazid Not assoc w R - Interim
ahpC 2726693 c.501C>G synonymous_variant 0.65 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.65 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.67 isoniazid
folC 2746390 c.1209G>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2746393 c.1206C>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2746401 p.Ser400Ala missense_variant 0.36 para-aminosalicylic_acid
folC 2746402 c.1197T>C synonymous_variant 0.35 para-aminosalicylic_acid
folC 2746414 c.1183_1185delGAGinsCA frameshift_variant&missense_variant 0.35 para-aminosalicylic_acid
folC 2746420 c.1179A>G synonymous_variant 0.35 para-aminosalicylic_acid
folC 2746426 c.1173G>C synonymous_variant 0.35 para-aminosalicylic_acid
folC 2746438 c.1161G>C synonymous_variant 0.31 para-aminosalicylic_acid
folC 2746478 p.Phe374Tyr missense_variant 0.3 para-aminosalicylic_acid
folC 2746480 c.1119A>C synonymous_variant 0.3 para-aminosalicylic_acid
Rv2477c 2782869 p.Ala392Thr missense_variant 0.37 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783059 c.984T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.55 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.58 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783221 c.822G>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.59 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.59 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2680 2995848 c.-257G>A upstream_gene_variant 1.0 capreomycin
Rv2681 2997287 c.549G>C synonymous_variant 0.19 capreomycin
Rv2752c 3064809 c.1383C>G synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064815 c.1377T>C synonymous_variant 0.44 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064831 p.Ala454Asn missense_variant 0.5 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064838 c.1354T>C synonymous_variant 0.47 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065087 c.1105A>C synonymous_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid Not assoc w R - Interim
Rv2752c 3065088 c.1104A>G synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065109 c.1081_1083delAGAinsCC frameshift_variant&missense_variant 0.4 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065115 c.1077C>A synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065142 c.1050A>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065151 c.1041G>C synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066102 c.90C>T synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066118 p.Asn25Ser missense_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066582 c.-392_-391delCCinsGG upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066855 c.-664T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067325 c.621A>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067376 c.570G>A synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.39 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.48 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.36 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.34 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.3 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.29 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.28 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.31 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.3 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.32 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.3 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.38 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073815 c.657G>A synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3073824 c.648A>G synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073836 c.636C>T synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.54 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.52 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.54 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.55 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.58 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.59 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.64 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.6 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.64 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.6 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAG frameshift_variant&missense_variant 0.43 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.53 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.41 para-aminosalicylic_acid
ald 3087680 c.861G>C synonymous_variant 0.29 cycloserine
ald 3087704 c.885T>C synonymous_variant 0.31 cycloserine
ald 3087716 c.897G>C synonymous_variant 0.35 cycloserine
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
Rv3236c 3613636 c.-520A>G upstream_gene_variant 1.0 pyrazinamide Not assoc w R
lpqB 3623703 p.Ala403Val missense_variant 0.3 bedaquiline
rifampicin
lpqB 3623705 c.1206C>T synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3623721 p.Ser397Thr missense_variant 0.4 bedaquiline
rifampicin
lpqB 3623766 p.Gly382Ala missense_variant 0.37 bedaquiline
rifampicin
lpqB 3624077 c.834G>A synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624082 c.829A>C synonymous_variant 0.45 bedaquiline
rifampicin
lpqB 3624086 c.825C>T synonymous_variant 0.45 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624092 c.817_819delAGGinsCC frameshift_variant&missense_variant 0.45 bedaquiline
rifampicin Uncertain significance
lpqB 3624100 c.811T>C synonymous_variant 0.47 bedaquiline
rifampicin
lpqB 3624101 c.810C>G synonymous_variant 0.47 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.39 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.41 bedaquiline
rifampicin
lpqB 3624143 c.768T>C synonymous_variant 0.46 bedaquiline
rifampicin
lpqB 3624701 c.210T>C synonymous_variant 0.36 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.43 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.46 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.47 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.47 bedaquiline
rifampicin
lpqB 3624776 c.135T>C synonymous_variant 0.47 bedaquiline
rifampicin
lpqB 3624783 p.Ser43Thr missense_variant 0.44 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625225 c.-315G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625240 c.-330T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625243 c.-333T>G upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.56 bedaquiline
rifampicin
lpqB 3625549 c.-639G>A upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.69 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.68 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.68 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.68 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.62 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.63 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.55 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.53 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.63 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.63 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.67 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.64 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.72 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.71 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.69 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.33 bedaquiline
rifampicin
mtrB 3626840 c.-227C>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626972 c.-359A>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrA 3627227 c.123T>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627242 c.108C>T synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.47 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.47 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.42 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.57 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.61 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.5 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.45 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.36 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.39 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.36 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.36 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.42 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.38 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.41 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.39 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.35 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.34 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.33 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.35 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.4 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.33 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.36 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.38 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.36 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.35 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.35 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.35 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.69 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.69 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.77 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.77 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.77 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.77 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.71 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.71 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.8 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.77 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.64 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.6 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.7 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.65 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.65 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.65 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.7 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.65 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.63 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.56 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.46 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.62 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.74 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.75 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.74 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.66 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.6 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.6 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.59 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.48 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.43 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.45 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.45 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.45 rifampicin
clpC1 4038293 c.2412G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.44 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.36 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.37 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.37 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.34 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.43 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.44 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.48 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.44 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.44 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.54 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.57 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.57 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.42 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.44 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.59 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.48 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.42 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.52 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.65 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.71 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.62 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.45 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.53 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4039556 c.1149G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.67 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.67 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.69 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.77 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.62 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.64 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.68 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.76 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.69 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.39 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.4 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.48 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.56 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.59 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.52 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.48 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.47 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.5 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.47 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.47 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.47 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.52 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.61 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.61 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.58 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.5 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.5 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.5 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.49 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.38 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.29 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.29 pyrazinamide
panD 4044833 c.-552A>G upstream_gene_variant 0.29 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.37 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.4 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.43 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.33 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.35 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.33 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.37 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.4 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.42 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.45 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.42 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.42 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.4 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.35 pyrazinamide
panD 4045094 c.-813T>C upstream_gene_variant 0.31 pyrazinamide
panD 4045097 c.-816T>C upstream_gene_variant 0.35 pyrazinamide
panD 4045105 c.-824T>C upstream_gene_variant 0.37 pyrazinamide
panD 4045112 c.-831A>G upstream_gene_variant 0.38 pyrazinamide
glpK 4138643 c.1113A>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138646 c.1110G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.33 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138808 c.948G>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138822 p.Asn312Asp missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139143 c.613T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.573T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>C synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139195 c.561G>T synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139198 c.558C>G synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139207 c.549T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139231 c.525A>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.5 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.52 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.52 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.5 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.37 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.37 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.39 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.27 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.23 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.24 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.3 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.35 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.38 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.38 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.38 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.39 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.45 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.56 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.54 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.55 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.5 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.44 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.43 ethambutol
embC 4241179 c.1317G>A synonymous_variant 0.42 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.32 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embC 4241218 c.1356G>C synonymous_variant 0.26 ethambutol
embC 4241394 p.Lys511Ser missense_variant 0.26 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.48 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.39 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.39 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.37 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.36 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.37 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.35 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.35 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.35 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.43 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>G synonymous_variant 0.5 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.48 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.43 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.43 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.43 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.5 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.52 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.48 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.54 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.56 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.56 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.83 ethambutol Not assoc w R
embA 4242742 c.-491C>G upstream_gene_variant 0.28 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.26 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.24 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.24 ethambutol
embA 4242772 c.-461G>C upstream_gene_variant 0.28 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.28 ethambutol
embA 4244690 c.1458G>A synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embA 4244702 c.1470C>G synonymous_variant 0.29 ethambutol
embA 4244708 c.1476C>G synonymous_variant 0.27 ethambutol
embA 4244728 p.Phe499Trp missense_variant 0.32 ethambutol
embA 4245044 c.1812G>C synonymous_variant 0.36 ethambutol
embA 4245053 c.1821G>C synonymous_variant 0.44 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.5 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.51 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.54 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.62 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.63 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.61 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.6 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.58 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.61 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.58 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.57 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.56 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.55 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.42 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.36 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.33 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4246250 c.-264G>C upstream_gene_variant 0.39 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.46 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.46 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.48 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.39 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.41 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.41 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.42 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.41 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.45 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.41 ethambutol
embA 4246359 c.3127_3129delGCCinsTG frameshift_variant&missense_variant 0.32 ethambutol Uncertain significance
embB 4246367 c.-147C>T upstream_gene_variant 0.25 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.4 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.44 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.52 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.43 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.5 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.45 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.48 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.39 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.29 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.28 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.26 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.27 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.32 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.36 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.41 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.45 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.45 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.44 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.36 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.33 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.38 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.38 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.28 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.26 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.25 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.26 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.27 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.27 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant<