TB-Profiler result

Run: ERR6865513
Summary

Run ID: ERR6865513

Sample name:

Date: 2024-10-05T04:44:42.850797

Number of reads: 874974

Percentage reads mapped: 49.09

Median coverage: 26.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.98
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid folC p.Glu40Gln Mutation from literature
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
folC 2747481 p.Glu40Gln missense_variant 1.0 para-aminosalicylic_acid Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6577 c.1338T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6590 p.Arg451Ser missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6631 c.-671C>T upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>T upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6697 c.1458C>T synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>T upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>T synonymous_variant 0.51 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6727 c.-575G>T upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6764 c.-538C>T upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6775 c.-527G>T upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6796 c.-506C>T upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrB 6798 p.Gly520Ala missense_variant 0.42 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.37 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7018 c.-284G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7024 c.-278G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7072 c.-230G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 7100 c.1861T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7120 c.-182T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7421 c.120G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7430 c.129G>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7466 c.165G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7469 c.168C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7601 c.300C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7619 c.318C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7640 c.339G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7643 c.342C>A synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Lys missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.44 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9026 c.1725G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9063 p.Ser588Ala missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9753 p.Asn818Asp missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
fgd1 491591 p.Lys270Met missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
mshA 575679 p.Asn111Ser missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
nusG 734424 c.171G>T synonymous_variant 0.31 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.41 rifampicin
nusG 734445 c.192C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
nusG 734452 p.Glu67Gln missense_variant 0.42 rifampicin Uncertain significance
nusG 734460 c.207G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734497 p.Val82Ile missense_variant 0.36 rifampicin Uncertain significance
nusG 734532 c.279A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
nusG 734544 c.291C>T synonymous_variant 0.33 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.29 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.94 rifampicin Not assoc w R
rpoB 760223 c.417T>C synonymous_variant 0.34 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.47 rifampicin Uncertain significance
rpoB 760276 p.Lys157Met missense_variant 0.47 rifampicin Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.42 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.39 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.39 rifampicin
rpoB 760317 c.511_513delAGCinsTCG synonymous_variant 0.39 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.38 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.38 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.42 rifampicin
rpoB 760343 c.537G>C synonymous_variant 0.39 rifampicin
rpoB 760357 p.Thr184Asn missense_variant 0.42 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.43 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.47 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.41 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.26 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.26 rifampicin Uncertain significance
rpoB 760412 c.606C>T synonymous_variant 0.28 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>A synonymous_variant 0.29 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760433 c.627C>T synonymous_variant 0.29 rifampicin
rpoB 760454 c.648C>G synonymous_variant 0.33 rifampicin
rpoB 760457 c.651C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760469 c.663C>T synonymous_variant 0.34 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.34 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.32 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.47 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.5 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>T synonymous_variant 0.51 rifampicin
rpoB 760561 c.757_758delCG frameshift_variant 0.57 rifampicin
rpoB 760567 c.761delCinsGGG frameshift_variant&missense_variant 0.53 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.51 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.47 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.46 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.45 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.44 rifampicin
rpoB 760607 c.801G>C synonymous_variant 0.47 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760668 p.Thr288Ala missense_variant 0.24 rifampicin Uncertain significance
rpoB 760674 c.868T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.24 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.29 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.34 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Leu missense_variant 0.36 rifampicin
rpoB 760877 c.1071G>C synonymous_variant 0.35 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.35 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.35 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.35 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.47 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.45 rifampicin Uncertain significance
rpoB 760973 c.1167G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.47 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.49 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.49 rifampicin
rpoB 761126 c.1320G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761159 c.1353G>T synonymous_variant 0.45 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761178 p.Ser458Thr missense_variant 0.37 rifampicin Uncertain significance
rpoB 761186 p.Glu460Asp missense_variant 0.34 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>T synonymous_variant 0.33 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.2 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.52 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.44 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.46 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.47 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.43 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.4 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.42 rifampicin
rpoB 761717 c.1911C>T synonymous_variant 0.39 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.38 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.38 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.38 rifampicin
rpoB 761732 c.1926C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761741 c.1935G>A synonymous_variant 0.36 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.38 rifampicin
rpoB 761760 p.Ile652Val missense_variant 0.37 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.36 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.33 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.31 rifampicin
rpoB 761789 c.1983G>C synonymous_variant 0.24 rifampicin
rpoB 761791 p.Arg662Gln missense_variant 0.25 rifampicin
rpoB 761794 p.Thr663Ser missense_variant 0.24 rifampicin
rpoB 761802 p.Met666Leu missense_variant 0.26 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.22 rifampicin
rpoB 761906 c.2100C>T synonymous_variant 0.21 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.21 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.21 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.21 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.21 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.25 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.25 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.25 rifampicin
rpoB 761936 c.2130C>T synonymous_variant 0.25 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>T synonymous_variant 0.31 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.31 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>T synonymous_variant 0.32 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.31 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.29 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.29 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.29 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.29 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.34 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762221 c.2415G>A synonymous_variant 0.44 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.28 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762830 c.-540C>T upstream_gene_variant 0.17 rifampicin
rpoB 762836 c.3030C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.32 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762911 c.-459C>T upstream_gene_variant 0.34 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.39 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763034 c.-336C>A upstream_gene_variant 0.4 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.44 rifampicin
rpoB 763157 c.3351G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763187 c.-183C>G upstream_gene_variant 0.29 rifampicin
rpoB 763193 c.3387C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>G upstream_gene_variant 0.27 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.24 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763415 p.Thr16Ser missense_variant 0.24 rifampicin Uncertain significance
rpoC 763423 p.Glu18Asp missense_variant 0.24 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCGT synonymous_variant 0.24 rifampicin
rpoC 763433 p.Gln22Asn missense_variant 0.25 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.25 rifampicin
rpoC 763450 c.81G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.48 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.42 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.42 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.41 rifampicin
rpoC 763714 c.345G>A synonymous_variant 0.42 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.42 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.42 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.41 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.39 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.29 rifampicin
rpoC 763768 c.399C>T synonymous_variant 0.29 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.3 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.26 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.21 rifampicin
rpoC 764320 c.951C>A synonymous_variant 0.21 rifampicin
rpoC 764339 c.970C>T synonymous_variant 0.28 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.3 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.44 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.45 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764506 c.1137C>T synonymous_variant 0.37 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.4 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.39 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.38 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.37 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.35 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764810 p.Pro481Ala missense_variant 0.46 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.47 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.39 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.39 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1644delAGCinsTCG synonymous_variant 0.2 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.19 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.2 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.22 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.93 rifampicin Not assoc w R
rpoC 765379 c.2010G>C synonymous_variant 0.31 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.31 rifampicin Uncertain significance
rpoC 765394 c.2025G>A synonymous_variant 0.35 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 0.33 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.31 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765412 c.2043T>C synonymous_variant 0.32 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765449 p.Ala694Ser missense_variant 0.36 rifampicin Uncertain significance
rpoC 765454 c.2085C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.31 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 0.32 rifampicin Uncertain significance
rpoC 765496 c.2127C>T synonymous_variant 0.32 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.26 rifampicin
rpoC 765533 p.Tyr722His missense_variant 0.25 rifampicin Uncertain significance
rpoC 765868 c.2499G>A synonymous_variant 0.21 rifampicin
rpoC 765871 c.2502T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.22 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.24 rifampicin
rpoC 765907 c.2538G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.33 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCTT synonymous_variant 0.36 rifampicin
rpoC 765973 c.2604C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767100 p.Lys1244Arg missense_variant 0.2 rifampicin
rpoC 767104 c.3735C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767128 c.3759C>T synonymous_variant 0.27 rifampicin
rpoC 767134 c.3765C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>T synonymous_variant 0.35 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 0.33 rifampicin Uncertain significance
rpoC 767188 c.3819G>A synonymous_variant 0.33 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.36 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.4 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>T synonymous_variant 0.44 rifampicin
rpoC 767233 c.3864T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767254 c.3885G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Ser missense_variant 0.37 rifampicin Uncertain significance
rpoC 767267 p.Ala1300Asn missense_variant 0.35 rifampicin Uncertain significance
rpoC 767281 c.3912C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767302 c.3933C>A synonymous_variant 0.3 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781276 c.-284A>C upstream_gene_variant 1.0 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781670 c.111G>C synonymous_variant 0.31 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.34 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.32 streptomycin
rpsL 781715 c.156T>G synonymous_variant 0.31 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.27 streptomycin
rpsL 781725 p.Lys56Arg missense_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.24 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.24 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.24 streptomycin
rpsL 781737 p.Gln60Ala missense_variant 0.24 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.26 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.26 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.28 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.27 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.27 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.43 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.34 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.34 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.33 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.32 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.24 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.26 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.23 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.22 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.22 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.22 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.22 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.24 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.22 streptomycin
rplC 800639 c.-170C>T upstream_gene_variant 0.2 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.22 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.21 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.26 linezolid
rplC 800666 c.-143C>T upstream_gene_variant 0.26 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.26 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.24 linezolid
rplC 800703 c.-106_-104delTTGinsCTC upstream_gene_variant 0.26 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.25 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.26 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.26 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.24 linezolid
rplC 800747 c.-62C>T upstream_gene_variant 0.24 linezolid
fbiC 1304502 c.1572G>A synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
rrs 1471634 n.-212C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.53 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524_525insT non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474184 n.527C>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474415 n.759_781delCACACGCGCATACGCGCGTGTGA non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474630 n.973T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474709 n.1052_1057delGTGGTGinsAATAAGT non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833604 c.63C>T synonymous_variant 0.37 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.34 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.35 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.39 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.45 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.49 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.46 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.45 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.44 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.41 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.46 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.43 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.44 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833751 c.210C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1833760 c.219C>T synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.48 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.47 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.5 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.5 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.5 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.56 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.57 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.56 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.54 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.54 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.56 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.57 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.49 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.49 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.49 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834073 p.Lys178Arg missense_variant 0.37 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.47 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.47 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.5 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.54 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.6 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>T synonymous_variant 0.65 pyrazinamide
rpsA 1834405 c.864C>T synonymous_variant 0.63 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.63 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.63 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.65 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.61 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.57 pyrazinamide
rpsA 1834480 c.939C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.49 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.51 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.49 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.47 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.48 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.48 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.4 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.38 pyrazinamide
rpsA 1834684 c.1143C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834700 p.Gln387Ala missense_variant 0.26 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517917 c.-198G>C upstream_gene_variant 0.34 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.34 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
Rv2477c 2783299 c.744A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783341 c.702C>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783449 c.594C>T synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625720 c.894G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625744 c.870G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.27 rifampicin Uncertain significance
bedaquiline
mtrB 3625761 p.Gln285Glu missense_variant 0.26 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625768 c.-858G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625792 c.822G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625801 c.-891G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625807 c.-897C>A upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625820 p.Glu265Val missense_variant 0.15 rifampicin Uncertain significance
bedaquiline
mtrB 3626704 c.-91C>T upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626711 c.-98T>C upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626717 c.-104C>T upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrA 3626741 c.609C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626750 c.-137T>G upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrA 3626756 c.594C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626762 c.588G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626765 c.585C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626776 c.-163A>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626852 c.-239G>A upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626857 c.-244T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.19 rifampicin
bedaquiline
rpoA 3877554 c.954G>C synonymous_variant 0.23 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877560 c.948C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877569 p.Pro313Thr missense_variant 0.31 rifampicin Uncertain significance
rpoA 3877587 c.921A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.38 rifampicin
rpoA 3877602 c.906C>T synonymous_variant 0.4 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.54 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.56 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>T synonymous_variant 0.59 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.53 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.5 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.51 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.54 rifampicin
rpoA 3877758 c.750G>C synonymous_variant 0.53 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.52 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.55 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.54 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>T synonymous_variant 0.52 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.54 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.57 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.53 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877929 p.Ile193Val missense_variant 0.5 rifampicin Uncertain significance
rpoA 3877962 c.546G>C synonymous_variant 0.43 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.42 rifampicin
rpoA 3877977 p.Lys177Asn missense_variant 0.4 rifampicin Uncertain significance
rpoA 3877983 c.525C>G synonymous_variant 0.38 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.37 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>C synonymous_variant 0.38 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.38 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.38 rifampicin
rpoA 3878028 c.480G>T synonymous_variant 0.37 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.37 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.39 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.41 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.41 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.42 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.44 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.5 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.55 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.63 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.62 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.63 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.64 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.63 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.59 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878175 c.333G>T synonymous_variant 0.71 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.67 rifampicin Uncertain significance
rpoA 3878205 c.303T>A synonymous_variant 0.69 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878274 c.234G>C synonymous_variant 0.67 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.67 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.66 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.67 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.61 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.61 rifampicin
rpoA 3878373 c.135G>C synonymous_variant 0.61 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878400 c.108T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878424 c.84G>C synonymous_variant 0.4 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.57 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.53 rifampicin
rpoA 3878725 c.-218A>C upstream_gene_variant 0.38 rifampicin
rpoA 3878775 c.-268A>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878782 c.-275G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.24 rifampicin
rpoA 3878794 c.-287G>T upstream_gene_variant 0.23 rifampicin
rpoA 3878797 c.-290G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878803 c.-296G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878806 c.-299C>A upstream_gene_variant 0.22 rifampicin
rpoA 3878811 c.-304A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878814 c.-307C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878823 c.-316G>T upstream_gene_variant 0.22 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.22 rifampicin
clpC1 4038767 c.1938G>T synonymous_variant 0.32 pyrazinamide
clpC1 4038770 c.1935C>A synonymous_variant 0.32 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.36 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038818 c.1887G>A synonymous_variant 0.42 pyrazinamide
clpC1 4038842 c.1863G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.39 pyrazinamide
clpC1 4038860 c.1845G>T synonymous_variant 0.39 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038881 c.1824C>A synonymous_variant 0.25 pyrazinamide
clpC1 4038884 c.1821C>T synonymous_variant 0.28 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.24 pyrazinamide
clpC1 4038896 c.1809C>A synonymous_variant 0.23 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.23 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.23 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038923 c.1782A>T synonymous_variant 0.23 pyrazinamide
clpC1 4038928 c.1777C>A synonymous_variant 0.23 pyrazinamide
clpC1 4038929 c.1776G>A synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038932 c.1773G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039077 p.Lys543Arg missense_variant 0.3 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039082 c.1623C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.33 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.36 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039139 c.1566G>A synonymous_variant 0.35 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039166 c.1539G>A synonymous_variant 0.35 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.32 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.29 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039238 c.1467C>T synonymous_variant 0.41 pyrazinamide
clpC1 4039265 c.1440C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039280 c.1425G>T synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039283 c.1422C>T synonymous_variant 0.42 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.41 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.42 pyrazinamide
clpC1 4039316 p.Glu463Asp missense_variant 0.37 pyrazinamide
clpC1 4039319 c.1386T>A synonymous_variant 0.37 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.37 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039336 c.1369C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039338 p.Thr456Gln missense_variant 0.35 pyrazinamide
clpC1 4039346 p.Arg453Ser missense_variant 0.37 pyrazinamide
clpC1 4039360 p.Ser449Arg missense_variant 0.38 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.28 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.28 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039451 c.1254G>A synonymous_variant 0.2 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.21 pyrazinamide
clpC1 4039457 c.1248C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039484 c.1221T>A synonymous_variant 0.23 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039553 c.1152C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.28 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.29 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039610 c.1095G>T synonymous_variant 0.34 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.41 pyrazinamide
clpC1 4039649 c.1056G>T synonymous_variant 0.46 pyrazinamide
clpC1 4039652 c.1053G>T synonymous_variant 0.45 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039745 c.960C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039751 c.954A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039814 c.891C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.39 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039874 c.831C>T synonymous_variant 0.41 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.34 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040000 c.705C>T synonymous_variant 0.52 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.5 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040051 c.654C>T synonymous_variant 0.47 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.5 pyrazinamide
clpC1 4040087 c.618G>T synonymous_variant 0.36 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.32 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
glpK 4138535 p.Asp407Glu missense_variant 0.18 levofloxacin
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4138568 c.1188A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138574 c.1182G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138579 c.1177C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138580 c.1176C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin