TB-Profiler result

Run: SRR16278274
Summary

Run ID: SRR16278274

Sample name:

Date: 2024-04-15T05:30:08.008262

Number of reads: 4590361

Percentage reads mapped: 37.89

Median coverage: 87.0

Strain: La1.4

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.4 M.bovis None 1.0
La1 M.bovis None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance Mutation from literature
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6172 c.933C>T synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrB 6406 c.1167C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6695 c.1456_1458delATCinsCG frameshift_variant&missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6718 p.Ile493Met missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6733 c.-569G>A upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6737 p.Thr500Ala missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6742 c.-560A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6779 p.His514Asn missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 6784 c.-518C>T upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6787 c.-515G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.32 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8285 c.984C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 0.99 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
nusG 734666 p.Arg138His missense_variant 1.0 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.18 rifampicin
rpoB 760334 c.528G>C synonymous_variant 0.17 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.17 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.17 rifampicin
rpoB 760372 c.566_567insGGAG frameshift_variant 0.24 rifampicin
rpoB 760375 p.Asp190Ala missense_variant 0.23 rifampicin Uncertain significance
rpoB 760376 c.571_574delAAGA frameshift_variant 0.24 rifampicin
rpoB 760389 c.583_584delAGinsTC synonymous_variant 0.23 rifampicin
rpoB 760394 c.588C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760400 c.594G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760407 c.601_603delAGCinsTCG synonymous_variant 0.22 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760436 c.630C>G synonymous_variant 0.32 rifampicin
rpoB 760457 c.651C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Thr missense_variant 0.16 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.14 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761998 c.2193_2195delGTC disruptive_inframe_deletion 0.35 rifampicin
rpoB 762005 c.2200_2201insAGC disruptive_inframe_insertion 0.34 rifampicin
rpoB 762009 p.Leu735Val missense_variant 0.35 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762020 c.2214G>A synonymous_variant 0.35 rifampicin
rpoB 762024 c.2218_2220delGTGinsAC frameshift_variant&missense_variant 0.34 rifampicin
rpoB 762035 c.2229G>C synonymous_variant 0.35 rifampicin
rpoB 762036 c.2230_2232delATCinsGG frameshift_variant&missense_variant 0.35 rifampicin
rpoB 762044 c.2238C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762050 c.2244G>A synonymous_variant 0.35 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.47 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762104 p.Asp766Glu missense_variant 0.56 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.53 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.49 rifampicin
rpoB 762125 p.Glu773Asp missense_variant 0.47 rifampicin
rpoB 762132 p.Ala776Lys missense_variant 0.47 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.52 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.54 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762173 p.Glu789Asp missense_variant 0.57 rifampicin
rpoB 762176 c.2370T>G synonymous_variant 0.56 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762197 c.2391C>G synonymous_variant 0.58 rifampicin
rpoB 762218 c.2412T>C synonymous_variant 0.53 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.32 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762844 p.Phe1013Tyr missense_variant 0.15 rifampicin
rpoB 762846 p.Pro1014Lys missense_variant 0.15 rifampicin
rpoB 762855 c.3049_3051delGTCinsAT frameshift_variant&missense_variant 0.17 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.16 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762878 p.Ile1024Met missense_variant 0.18 rifampicin
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.18 rifampicin
rpoB 762905 p.Asp1033Glu missense_variant 0.38 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 762938 c.-432G>C upstream_gene_variant 0.51 rifampicin
rpoC 762944 c.-426C>T upstream_gene_variant 0.52 rifampicin
rpoC 762947 c.-423C>G upstream_gene_variant 0.52 rifampicin
rpoC 762971 c.-399G>C upstream_gene_variant 0.54 rifampicin
rpoC 762980 c.-390T>C upstream_gene_variant 0.56 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.56 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.59 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.62 rifampicin
rpoC 763022 c.-348C>A upstream_gene_variant 0.63 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763052 c.-318G>T upstream_gene_variant 0.67 rifampicin
rpoB 763074 p.Thr1090Val missense_variant 0.59 rifampicin
rpoC 763079 c.-291C>G upstream_gene_variant 0.58 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.56 rifampicin
rpoB 763106 c.3300C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763109 c.-261C>G upstream_gene_variant 0.56 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763118 p.Glu1104Asp missense_variant 0.55 rifampicin
rpoB 763130 p.Glu1108Asp missense_variant 0.54 rifampicin
rpoC 763139 c.-231C>T upstream_gene_variant 0.51 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.49 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.46 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.37 rifampicin
rpoC 763178 c.-192G>C upstream_gene_variant 0.28 rifampicin
rpoB 763185 c.3379_3381delCTCinsTG frameshift_variant&missense_variant 0.16 rifampicin
rpoC 763453 c.84C>G synonymous_variant 0.19 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763462 c.93G>C synonymous_variant 0.33 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763471 c.102C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.38 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763517 p.Lys50Arg missense_variant 0.39 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.42 rifampicin
rpoC 763534 c.165T>C synonymous_variant 0.42 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Ala missense_variant 0.42 rifampicin
rpoC 763570 c.201G>T synonymous_variant 0.48 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763578 p.Phe70Tyr missense_variant 0.49 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763609 c.240C>T synonymous_variant 0.47 rifampicin
rpoC 763619 p.Arg84Lys missense_variant 0.43 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.41 rifampicin Uncertain significance
rpoC 763633 c.264T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.46 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.4 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763672 c.303C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.36 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.32 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.32 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.3 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.27 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.15 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.21 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764404 c.1035C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 764410 c.1041G>T synonymous_variant 0.43 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.4 rifampicin
rpoC 764429 c.1060C>T synonymous_variant 0.4 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCC frameshift_variant&missense_variant 0.4 rifampicin
rpoC 764438 p.Leu357Met missense_variant 0.4 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.43 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.41 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>G synonymous_variant 0.49 rifampicin
rpoC 764485 c.1116G>C synonymous_variant 0.51 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>T synonymous_variant 0.55 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.56 rifampicin
rpoC 764556 p.Asn396Thr missense_variant 0.59 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.6 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.63 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.69 rifampicin
rpoC 764623 c.1254C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.65 rifampicin
rpoC 764644 c.1275G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764653 c.1284G>C synonymous_variant 0.6 rifampicin
rpoC 764656 c.1287C>G synonymous_variant 0.6 rifampicin
rpoC 764659 c.1290C>T synonymous_variant 0.59 rifampicin
rpoC 764660 c.1291_1293delGTGinsAT frameshift_variant&missense_variant 0.59 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764687 p.Gln440Glu missense_variant 0.65 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Arg missense_variant 0.64 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.6 rifampicin
rpoC 764756 p.Leu463Asn missense_variant 0.54 rifampicin
rpoC 764759 p.Asn464Asp missense_variant 0.54 rifampicin
rpoC 764762 c.1393_1395delCATinsTC frameshift_variant&missense_variant 0.54 rifampicin
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.58 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.64 rifampicin
rpoC 764813 c.1444_1446delCAAinsGG frameshift_variant&missense_variant 0.63 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.61 rifampicin
rpoC 764838 p.Val490Ala missense_variant 0.55 rifampicin
rpoC 764842 c.1473C>T synonymous_variant 0.55 rifampicin
rpoC 764843 c.1474_1476delGCCinsTG frameshift_variant&missense_variant 0.55 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.57 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.57 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.52 rifampicin
rpoC 764913 p.Met515Lys missense_variant 0.51 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.5 rifampicin
rpoC 764926 c.1557C>T synonymous_variant 0.49 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.45 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764952 p.Val528Ala missense_variant 0.28 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>A synonymous_variant 0.2 rifampicin
rpoC 764998 c.1629G>C synonymous_variant 0.18 rifampicin
rpoC 766328 p.Lys987Gln missense_variant 0.23 rifampicin
rpoC 766333 c.2964G>C synonymous_variant 0.27 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.33 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766369 c.3000C>G synonymous_variant 0.32 rifampicin
rpoC 766378 c.3009C>T synonymous_variant 0.33 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.34 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.34 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766390 c.3021C>T synonymous_variant 0.34 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.34 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766423 c.3054T>C synonymous_variant 0.37 rifampicin
rpoC 766432 c.3063T>C synonymous_variant 0.36 rifampicin
rpoC 766434 p.Glu1022Gly missense_variant 0.36 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.35 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.35 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>C synonymous_variant 0.24 rifampicin
rpoC 767020 c.3651C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767023 p.Asp1218Glu missense_variant 0.27 rifampicin
rpoC 767026 c.3657G>C synonymous_variant 0.27 rifampicin
rpoC 767041 c.3672G>C synonymous_variant 0.25 rifampicin
rpoC 767044 c.3675G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767068 c.3699G>C synonymous_variant 0.24 rifampicin
rpoC 767071 c.3702C>G synonymous_variant 0.24 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.23 rifampicin
rpoC 767077 c.3708G>C synonymous_variant 0.23 rifampicin
rpoC 767087 p.Cys1240Lys missense_variant 0.23 rifampicin
rpoC 767093 c.3724_3725delAGinsTC synonymous_variant 0.24 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.26 rifampicin
rpoC 767110 c.3741T>C synonymous_variant 0.26 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 0.99 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781703 c.144G>T synonymous_variant 0.14 streptomycin
rpsL 781709 c.150G>T synonymous_variant 0.15 streptomycin
rpsL 781748 c.189C>T synonymous_variant 0.15 streptomycin
rpsL 781749 c.190_192delACGinsTC frameshift_variant&missense_variant 0.15 streptomycin Uncertain significance
rpsL 781760 c.201T>C synonymous_variant 0.22 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.24 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.41 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.4 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.37 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.38 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.39 streptomycin
rpsL 781850 c.291C>T synonymous_variant 0.41 streptomycin
rpsL 781851 p.Ile98Val missense_variant 0.41 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.4 streptomycin Not assoc w R - Interim
rpsL 781860 c.301_303delTCGinsGT frameshift_variant&missense_variant 0.41 streptomycin Uncertain significance
rpsL 781871 c.312G>C synonymous_variant 0.42 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.42 streptomycin
rpsL 781884 p.Asn109Asp missense_variant 0.41 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.4 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.37 streptomycin
rpsL 781902 c.343_344delAGinsTC synonymous_variant 0.34 streptomycin
rpsL 781916 c.357T>A synonymous_variant 0.21 streptomycin
rplC 800516 c.-293G>C upstream_gene_variant 0.13 linezolid
rplC 800522 c.-287C>T upstream_gene_variant 0.14 linezolid
rplC 800531 c.-278T>C upstream_gene_variant 0.14 linezolid
rplC 800537 c.-272C>G upstream_gene_variant 0.14 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.14 linezolid
rplC 800546 c.-263T>A upstream_gene_variant 0.14 linezolid
rplC 800549 c.-260G>C upstream_gene_variant 0.15 linezolid
rplC 800553 c.-256_-254delCGCinsAAG upstream_gene_variant 0.15 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.16 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.16 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.15 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.16 linezolid
rplC 800589 c.-220A>C upstream_gene_variant 0.16 linezolid
rplC 800597 c.-212A>T upstream_gene_variant 0.15 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.15 linezolid
rplC 800610 c.-199_-197delCTAinsTG upstream_gene_variant 0.18 linezolid
rplC 800615 c.-194G>C upstream_gene_variant 0.17 linezolid
rplC 800619 c.-190G>C upstream_gene_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 0.99 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471878 n.33C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80delTinsAGTG non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471931 n.86G>C non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471933 n.88_89delGAinsCTGG non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185delGinsATTTT non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472054 n.210_212delCGC non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472104 n.259G>A non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472278 n.433C>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472279 n.434T>C non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472312 n.467G>T non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468G>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.471_472insTGT non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472443 n.598A>T non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472466 n.621C>A non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472467 n.622G>C non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472485 n.640delGinsTA non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472671 n.826G>A non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472674 n.829_838delTTCCTTCCTTinsCCCTTCCAC non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472687 n.842A>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472689 n.844C>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472732 n.887G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472838 n.994dupC non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472842 n.997G>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472843 n.998A>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002_1004delGTCinsCG non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472858 n.1013G>C non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472866 n.1023dupT non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125_1130delCGTAATinsATTCG non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472977 n.1132G>T non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473091 n.1246_1248delGGCinsCGTT non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473099 n.1254T>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473112 n.1267A>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473120 n.1275C>G non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473134 n.1289T>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473135 n.1290C>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473282 n.1438_1439insGTT non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473285 n.1441_1448delCCCTCGGG non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474182 n.525C>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474183 n.526T>G non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1474199 n.542G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474202 n.546dupA non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474253 n.596A>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474286 n.629_651delCTCCTTTTCCTCTCCGGAGGAGGinsACCTT non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474311 n.654_655insT non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474372 n.717_718insTTGT non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474384 n.727C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474451 n.794T>C non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474487 n.830G>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474517 n.860C>G non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474784 n.1127C>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474793 n.1136C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474798 n.1141C>G non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.82 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474917 n.1260G>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474918 n.1261T>C non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474921 n.1264C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474953 n.1296C>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475057 n.1400G>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475063 n.1406A>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475076 n.1419C>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475094 n.1437C>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475110 n.1454_1457delGGCC non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1475118 n.1461C>T non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1475120 n.1463_1464insTCTT non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475137 n.1480A>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475170 n.1513A>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475171 n.1514C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475197 n.1540G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1475699 n.2042delCinsGTT non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1475704 n.2047C>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475758 n.2101_2112delACCCGCAAGGGTinsGGACATTGTCC non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475879 n.2222T>C non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.82 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475990 n.2333G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476023 n.2366C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476024 n.2367T>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1476029 n.2372A>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476077 n.2420T>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476082 n.2425T>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1476097 n.2440C>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476100 n.2443A>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476113 n.2456T>G non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1476116 n.2459A>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476210 n.2555_2556dupTG non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.92 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476307 n.2650A>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.9 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867_2868delCAinsT non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476535 n.2878G>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.82 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476624 n.2967T>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.11 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.44 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.54 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.57 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.61 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.62 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.63 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834025 c.484_486delCAGinsGT frameshift_variant&missense_variant 0.59 pyrazinamide Uncertain significance
rpsA 1834030 c.489C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.62 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.61 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.62 pyrazinamide
rpsA 1834076 p.Asn179His missense_variant 0.58 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834110 p.Trp190Tyr missense_variant 0.29 pyrazinamide
rpsA 1834118 p.Gln193Glu missense_variant 0.26 pyrazinamide
rpsA 1834131 p.Glu197Ala missense_variant 0.12 pyrazinamide
rpsA 1834183 c.642T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834255 c.714C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.39 pyrazinamide
rpsA 1834298 p.Gln253Ala missense_variant 0.38 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.37 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834321 c.780C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.19 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834492 c.951C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834523 p.Glu328Gln missense_variant 0.26 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.24 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834556 p.Ala339Asn missense_variant 0.24 pyrazinamide
rpsA 1834567 p.Asp342Glu missense_variant 0.24 pyrazinamide
rpsA 1834570 p.Asp343Glu missense_variant 0.24 pyrazinamide
rpsA 1834572 p.Ala344Val missense_variant 0.24 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.17 pyrazinamide
rpsA 1834637 c.1096_1098delAATinsGC frameshift_variant&missense_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834649 p.Thr370Val missense_variant 0.14 pyrazinamide
rpsA 1834663 c.1122C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.15 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2102706 p.Asp113His missense_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.99 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
Rv2477c 2782441 p.Glu534Ala missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782451 p.Ala531Asp missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 p.Ala520Gly missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782487 c.1555_1556insTGGAAG conservative_inframe_insertion 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782492 c.1542_1550delTGACGACGA disruptive_inframe_deletion 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782546 c.1497C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782549 c.1494T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 c.1116A>G synonymous_variant 0.98 ethambutol Not assoc w R
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
Rv2752c 3065372 p.Arg274Gly missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066574 c.-383T>C upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623730 p.Ser394Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
alr 3841474 c.-54T>G upstream_gene_variant 1.0 cycloserine
rpoA 3878630 c.-124delC upstream_gene_variant 0.98 rifampicin Not assoc w R
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038671 c.2034T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4038686 c.2019C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038694 p.Ser671Ala missense_variant 0.44 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.49 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038743 p.Thr654Asn missense_variant 0.52 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038766 p.Leu647Val missense_variant 0.54 pyrazinamide
clpC1 4038767 p.Arg646His missense_variant 0.55 pyrazinamide
clpC1 4038773 p.Asp644Glu missense_variant 0.56 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.56 pyrazinamide
clpC1 4038788 c.1917G>C synonymous_variant 0.58 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.58 pyrazinamide
clpC1 4038811 p.Gln632Lys missense_variant 0.6 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.59 pyrazinamide
clpC1 4038836 c.1869G>T synonymous_variant 0.5 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.39 pyrazinamide
clpC1 4038848 c.1857C>T synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4038860 c.1845G>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038863 c.1842G>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038887 c.1818G>A synonymous_variant 0.32 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.32 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.31 pyrazinamide
clpC1 4038914 c.1791G>A synonymous_variant 0.32 pyrazinamide
clpC1 4038923 c.1782A>C synonymous_variant 0.36 pyrazinamide
clpC1 4038926 c.1779G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038935 c.1770C>T synonymous_variant 0.34 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.31 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038974 c.1731T>G synonymous_variant 0.17 pyrazinamide
clpC1 4038979 p.Ala576Ser missense_variant 0.16 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039061 c.1644G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039730 c.975C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039754 c.951G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039784 c.919_921delATCinsCG frameshift_variant&missense_variant 0.36 pyrazinamide
clpC1 4039790 c.915C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039793 c.912C>A synonymous_variant 0.36 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039811 c.894C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.39 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.4 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.42 pyrazinamide
clpC1 4039838 c.865_867delCTGinsAT frameshift_variant&missense_variant 0.44 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039871 p.Thr278Gln missense_variant 0.45 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039910 c.795C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039916 c.789T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.27 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.24 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039958 c.745_747delACGinsTC frameshift_variant&missense_variant 0.24 pyrazinamide
clpC1 4039966 p.Leu247Val missense_variant 0.23 pyrazinamide
clpC1 4039973 p.Asp244Glu missense_variant 0.23 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040045 c.660C>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040063 c.642G>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.29 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040108 c.597G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040117 c.588A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040123 p.Glu194Asp missense_variant 0.26 pyrazinamide
clpC1 4040134 p.Ile191Val missense_variant 0.25 pyrazinamide
clpC1 4040135 c.570C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040157 p.Met183Lys missense_variant 0.27 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040192 c.513C>G synonymous_variant 0.2 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 0.99 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R