TB-Profiler result

Run: SRR18003019
Summary

Run ID: SRR18003019

Sample name:

Date: 2024-04-15T15:01:29.924964

Number of reads: 2457632

Percentage reads mapped: 73.36

Median coverage: 71.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.99
La1.2.BCG M.bovis None 0.06
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.98
lineage2.2 East-Asian (Beijing) RD105;RD207 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2224_2226delTTGinsCA Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.24 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305154 c.2224_2226delTTGinsCA frameshift_variant&missense_variant 0.17 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 756 c.756T>C synonymous_variant 0.16 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.17 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.18 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.17 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.18 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.19 isoniazid Uncertain significance
dnaA 819 c.819C>T synonymous_variant 0.19 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.19 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 840 c.840G>A synonymous_variant 0.18 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.18 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.19 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 876 c.876C>G synonymous_variant 0.18 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.16 isoniazid
dnaA 909 c.909A>T synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.17 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.16 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.19 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.19 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.19 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.19 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.19 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.2 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.19 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.2 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.2 isoniazid
dnaA 996 c.996A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 999 c.999C>G synonymous_variant 0.19 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.2 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.22 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.24 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.23 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.19 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.2 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.2 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.19 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.19 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.17 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.17 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.17 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1332 c.1332A>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.16 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.21 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.22 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.23 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.21 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.21 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.2 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.18 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.18 isoniazid
gyrB 6256 c.1017G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6670 c.-632G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.21 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7090 c.-212C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7514 c.213C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8225 c.924T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8401 p.Asp367Ala missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8543 c.1242C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8837 c.1536C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9089 c.1788G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.16 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
fgd1 490827 c.45C>T synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490935 c.153C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491077 p.Asn99Asp missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491083 p.Val101Ile missense_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575587 c.240C>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575590 c.243T>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575629 c.282A>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575632 c.285G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.18 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.17 ethionamide
isoniazid
mshA 575665 c.318G>A synonymous_variant 0.18 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.15 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575830 c.483C>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.17 ethionamide
isoniazid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 0.86 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620346 c.456C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>T synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656391 c.1080C>G synonymous_variant 0.19 ethionamide
Rv0565c 656402 p.Ala357Thr missense_variant 0.19 ethionamide
Rv0565c 656412 c.1059T>G synonymous_variant 0.21 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.19 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.22 ethionamide
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.19 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.18 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.18 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.19 ethionamide
Rv0565c 657027 c.444T>C synonymous_variant 0.22 ethionamide
Rv0565c 657056 p.Val139Leu missense_variant 0.19 ethionamide
Rv0565c 657060 c.411G>C synonymous_variant 0.19 ethionamide
Rv0565c 657065 p.Ser136Gly missense_variant 0.19 ethionamide
Rv0565c 657073 p.His133Leu missense_variant 0.16 ethionamide
Rv0565c 657079 p.His131Arg missense_variant 0.17 ethionamide
Rv0565c 657081 p.Val130Glu missense_variant 0.83 ethionamide
Rv0565c 657084 c.387C>G synonymous_variant 0.18 ethionamide
Rv0565c 657089 p.Asn128Asp missense_variant 0.17 ethionamide
Rv0565c 657093 c.378G>A synonymous_variant 0.2 ethionamide
Rv0565c 657114 c.357T>C synonymous_variant 0.17 ethionamide Not assoc w R - Interim
Rv0565c 657120 c.349_351delTCCinsGG frameshift_variant&missense_variant 0.18 ethionamide Uncertain significance
Rv0565c 657123 c.348A>C synonymous_variant 0.18 ethionamide
Rv0565c 657138 c.331_333delGCAinsTG frameshift_variant&missense_variant 0.22 ethionamide Uncertain significance
Rv0565c 657142 p.Arg110His missense_variant 0.78 ethionamide Uncertain significance
Rv0565c 657144 c.327T>G synonymous_variant 0.21 ethionamide
Rv0565c 657155 p.Asn106Asp missense_variant 0.18 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.22 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.22 ethionamide
hadA 732295 c.366G>C synonymous_variant 0.2 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.21 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.21 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.21 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.27 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.29 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.31 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.29 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.3 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.17 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.21 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.22 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.24 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.23 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.23 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.24 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.27 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.2 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.2 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.17 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.17 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.18 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.2 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.18 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.17 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.25 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.26 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.27 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.26 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.28 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.26 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.26 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.25 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.26 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.27 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760472 c.666C>T synonymous_variant 0.34 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.32 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.32 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.27 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.24 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.18 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.18 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.2 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.22 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.25 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.25 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.32 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.33 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.33 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.32 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.29 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761087 c.1281C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.31 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.27 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.24 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.25 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.27 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.24 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.24 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.22 rifampicin
rpoB 761373 p.Val523His missense_variant 0.23 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.28 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.25 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.25 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.24 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.24 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.23 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.21 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.22 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.22 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.28 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.23 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.22 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.22 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.22 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.23 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.21 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.23 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.19 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.19 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.25 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.27 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.27 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.33 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.31 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.31 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.32 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.35 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.3 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.32 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.29 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.28 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.28 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.27 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.23 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.21 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.21 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.21 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.21 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.22 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.27 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.38 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.38 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.39 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.38 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.42 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.37 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.36 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.34 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.33 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.21 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.21 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.23 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.21 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.19 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.19 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762410 c.2604T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762413 c.2607G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.2 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.24 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.19 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895His missense_variant 0.17 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.36 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.28 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.75 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.2 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.22 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.22 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.21 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.21 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.22 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.19 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.19 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.26 rifampicin
rpoC 763492 c.123G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.35 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.38 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.36 rifampicin
rpoC 763738 c.369G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.37 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.38 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.38 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.35 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.33 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.3 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.28 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.26 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.22 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.23 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.2 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.2 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.19 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.2 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.17 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.21 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.25 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.27 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.26 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.25 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.25 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.26 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.26 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.28 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.29 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.2 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.17 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.19 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>C synonymous_variant 0.19 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.18 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.21 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.23 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764381 p.Ser338Thr missense_variant 0.17 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.24 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.24 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.22 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.22 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.24 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.27 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.25 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.26 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.25 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.29 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.28 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.27 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.38 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.24 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.24 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1643delAGinsTC synonymous_variant 0.24 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.24 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765319 c.1950A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.17 rifampicin Uncertain significance
rpoC 765346 c.1977C>G synonymous_variant 0.21 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.28 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.27 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.28 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>A synonymous_variant 0.25 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.16 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.18 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.2 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.21 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.24 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.3 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.29 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.27 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.25 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.25 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.28 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.31 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.31 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.3 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.31 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.3 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.3 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.26 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.27 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.25 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.27 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.24 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.21 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.2 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.18 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.2 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.2 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.21 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.24 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.24 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.25 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.27 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.29 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.31 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.31 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.28 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.27 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.24 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.27 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.26 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.26 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.28 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.27 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.22 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.21 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.2 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.24 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.24 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.24 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.26 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.2 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.21 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.19 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.24 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.23 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.2 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.19 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.18 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.2 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.28 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.26 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.25 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.24 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.23 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.19 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.18 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.2 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775975 c.2506T>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.19 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781700 c.141G>C synonymous_variant 0.17 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.17 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.21 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.21 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.23 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.2 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.24 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.25 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.26 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.28 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.31 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.31 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.29 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.26 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.25 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.25 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.23 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.2 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.22 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.25 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.25 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.33 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.34 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.33 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.37 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.38 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.33 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.29 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.26 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.28 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.27 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.27 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.25 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.22 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.22 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.23 linezolid
rplC 800814 c.6A>G synonymous_variant 0.24 linezolid
rplC 800817 c.9A>T synonymous_variant 0.26 linezolid
rplC 800844 c.36T>C synonymous_variant 0.32 linezolid
rplC 800865 c.57A>G synonymous_variant 0.29 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.29 linezolid
rplC 800874 c.66A>G synonymous_variant 0.29 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.3 linezolid
rplC 800880 c.72A>G synonymous_variant 0.29 linezolid
rplC 800889 c.81C>G synonymous_variant 0.28 linezolid
rplC 800892 c.84G>C synonymous_variant 0.27 linezolid
rplC 800907 c.99C>G synonymous_variant 0.27 linezolid
rplC 800916 c.108A>G synonymous_variant 0.23 linezolid
rplC 800934 c.126C>G synonymous_variant 0.22 linezolid
rplC 800937 c.129A>G synonymous_variant 0.21 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.22 linezolid
rplC 800946 c.138T>C synonymous_variant 0.21 linezolid
rplC 800949 c.141T>C synonymous_variant 0.21 linezolid
rplC 801246 c.438C>T synonymous_variant 0.17 linezolid
rplC 801249 c.441T>C synonymous_variant 0.17 linezolid
rplC 801255 c.447C>T synonymous_variant 0.18 linezolid
rplC 801264 c.456C>T synonymous_variant 0.16 linezolid
rplC 801300 c.492C>G synonymous_variant 0.15 linezolid
rplC 801309 c.501C>G synonymous_variant 0.17 linezolid
rplC 801312 c.504G>C synonymous_variant 0.17 linezolid
rplC 801321 c.513C>T synonymous_variant 0.19 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.19 linezolid
rplC 801423 c.615G>C synonymous_variant 0.19 linezolid
rplC 801426 c.618C>G synonymous_variant 0.2 linezolid
rplC 801427 p.Met207Val missense_variant 0.2 linezolid
rplC 801438 c.630T>C synonymous_variant 0.22 linezolid
rplC 801442 p.Ile212Val missense_variant 0.22 linezolid
Rv1129c 1254559 c.-25G>T upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303632 c.702T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.25 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304132 p.Ala401Gly missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304161 p.Arg411Ser missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304187 c.1257T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304208 c.1278C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305332 p.Glu801Gly missense_variant 0.16 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
fabG1 1673289 c.-151G>A upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1674015 c.-187C>T upstream_gene_variant 0.17 ethionamide
isoniazid Uncertain significance
inhA 1674024 c.-178T>C upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.17 ethionamide
isoniazid
fabG1 1674037 p.Gln200Ala missense_variant 0.17 ethionamide
isoniazid
inhA 1674042 c.-160G>T upstream_gene_variant 0.16 ethionamide
isoniazid
fabG1 1674049 p.Gln204Glu missense_variant 0.17 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.17 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.17 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.15 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.18 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.23 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.28 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834303 c.762T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834510 c.969C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.43 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.42 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.28 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.21 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.18 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.18 pyrazinamide
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.16 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064912 c.-184A>G upstream_gene_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064915 c.-187G>C upstream_gene_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518506 p.Ala131Glu missense_variant 0.15 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.19 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.19 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.22 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.19 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.19 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.19 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.18 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.18 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.19 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.18 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.18 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.17 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.15 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.18 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.24 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.24 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.22 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.24 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.25 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.25 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.24 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.24 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.27 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.29 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.27 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.23 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.19 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.2 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.2 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.18 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.16 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.17 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.18 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.18 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.17 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.16 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.19 isoniazid
folC 2746321 c.1278A>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746329 c.1270C>A synonymous_variant 0.16 para-aminosalicylic_acid
folC 2746420 c.1179A>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746426 c.1173G>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746438 c.1161G>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.17 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.17 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.17 para-aminosalicylic_acid
Rv2477c 2782894 c.1149C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783107 c.936G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.24 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783437 c.606G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 p.Leu182Phe missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2784441 c.-399G>A upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784454 c.-412G>A upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2681 2996380 c.-359C>G upstream_gene_variant 0.17 capreomycin
Rv2680 2996381 p.Ser93Ala missense_variant 0.17 capreomycin
Rv2680 2996386 c.282T>C synonymous_variant 0.18 capreomycin Not assoc w R - Interim
Rv2681 2996389 c.-350A>G upstream_gene_variant 0.18 capreomycin
Rv2680 2996408 p.Leu102Met missense_variant 0.18 capreomycin
Rv2752c 3065993 p.Val67Ile missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066002 p.Met64Leu missense_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066003 c.189C>T synonymous_variant 0.21 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin
isoniazid
Rv2752c 3066009 c.183G>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066018 c.174T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066041 p.Gly51Ser missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066050 p.Leu48Met missense_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067439 c.507A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067442 c.504C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.21 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067510 c.436C>T synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.3 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.28 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.34 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.32 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.32 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.3 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.31 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.34 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.38 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.22 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.24 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.25 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073941 c.531C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074100 c.370_372delGATinsAC frameshift_variant&synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074147 p.Ile109Val missense_variant 0.18 para-aminosalicylic_acid
thyA 3074157 c.313_315delTCCinsAG frameshift_variant&stop_gained 0.18 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAG frameshift_variant&missense_variant 0.17 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.17 para-aminosalicylic_acid
thyA 3074213 p.Thr87Ala missense_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624041 p.Glu290Asp missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624050 c.861C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624077 c.834G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624086 c.825C>T synonymous_variant 0.18 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624371 c.540T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624404 c.507G>T synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624407 c.504C>T synonymous_variant 0.2 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624410 c.501C>T synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624416 c.495G>A synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ala missense_variant 0.2 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624437 c.474G>A synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624461 c.450C>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624482 c.429T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624485 p.Asp142Gly missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624491 c.420G>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.156A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625069 c.-159T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625087 c.1525_1527delGCCinsTG frameshift_variant&missense_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625093 p.Glu507Asp missense_variant 0.22 bedaquiline
rifampicin
lpqB 3625099 c.-189C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.26 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.27 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.27 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625206 p.Ser470Ala missense_variant 0.25 bedaquiline
rifampicin
lpqB 3625218 c.-308C>A upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625225 c.-315G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625572 p.Thr348Ser missense_variant 0.16 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.27 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.34 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.32 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.29 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3626723 c.627C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626729 c.-116G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.28 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626945 c.-332C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627167 c.-554T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627299 c.51G>A synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
fbiB 3642566 c.1032A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiB 3642581 c.1047A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642587 p.Met351Ile missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642593 c.1059G>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642609 c.1075_1076delAGinsTC synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642617 c.1083C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiB 3642659 c.1125C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
rpoA 3877515 c.993G>C synonymous_variant 0.19 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.26 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.27 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.3 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.19 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.24 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.25 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.26 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.24 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.24 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.24 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.24 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.21 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.19 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.19 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.2 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.2 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.19 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.2 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.21 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.21 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878055 c.453A>G synonymous_variant 0.18 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.17 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.17 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.17 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.17 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.19 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.22 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.29 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.3 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.3 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.33 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.33 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.3 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.26 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.25 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.23 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.2 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.2 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.2 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.2 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.19 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.19 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.19 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.19 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.22 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.2 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.26 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.29 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.34 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.36 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.44 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.42 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.41 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.39 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.25 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.2 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.19 rifampicin
clpC1 4038388 c.2317T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.29 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.25 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.28 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.28 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.26 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.28 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.29 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038530 c.2175G>A synonymous_variant 0.24 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.18 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.18 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.18 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038749 c.1956C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.31 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.28 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.25 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.26 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039718 c.987C>A synonymous_variant 0.28 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.25 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.28 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.27 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.2 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.2 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.18 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.16 pyrazinamide
panD 4044926 c.-645C>A upstream_gene_variant 0.16 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.17 pyrazinamide
panD 4044935 c.-655_-654delAAinsTG upstream_gene_variant 0.18 pyrazinamide
panD 4044941 c.-660G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.21 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.25 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.25 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.25 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.25 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.25 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.21 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.21 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.21 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.2 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.19 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.16 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.16 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.16 pyrazinamide
glpK 4138529 c.1227G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138646 c.1110G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138805 c.951C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138808 c.948G>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138822 p.Asn312Asp missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138829 c.927A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138838 c.918G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138841 c.915G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240216 c.354T>C synonymous_variant 0.16 ethambutol
embC 4240219 c.357C>G synonymous_variant 0.16 ethambutol
embC 4240233 p.Gln124Leu missense_variant 0.15 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.15 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.17 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.16 ethambutol Uncertain significance
embC 4240924 c.1062C>G synonymous_variant 0.16 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.19 ethambutol
embC 4240945 c.1083T>G synonymous_variant 0.18 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.15 ethambutol
embC 4240960 c.1098G>C synonymous_variant 0.15 ethambutol
embC 4241013 p.Met384Thr missense_variant 0.16 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.16 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.17 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.16 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.17 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.17 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.17 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.18 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.18 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.19 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.22 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.17 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.17 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.17 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.2 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.2 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.2 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.19 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.18 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.18 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.18 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.19 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>G synonymous_variant 0.18 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.18 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.21 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.18 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.19 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.19 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242772 c.-461G>C upstream_gene_variant 0.16 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.16 ethambutol
embC 4242791 p.Ala977Ser missense_variant 0.16 ethambutol
embA 4242820 c.-413G>C upstream_gene_variant 0.2 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.2 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.2 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.2 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embA 4242844 c.-389A>G upstream_gene_variant 0.19 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.19 ethambutol
embA 4242859 c.-374C>T upstream_gene_variant 0.18 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 0.17 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.17 ethambutol
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244582 c.1350T>C synonymous_variant 0.17 ethambutol
embA 4244585 c.1353A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embA 4244616 p.Ala462Ser missense_variant 0.15 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.19 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.21 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.22 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.22 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.23 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.21 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.17 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.18 ethambutol
embB 4245596 c.-918C>T upstream_gene_variant 0.98 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.15 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.17 ethambutol
embB 4246367 c.-147C>T upstream_gene_variant 0.15 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.17 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.17 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.17 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.16 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.17 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.21 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.19 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.18 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.2 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.16 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.17 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.18 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.17 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.17 ethambutol
embB 4247590 c.1077A>C synonymous_variant 0.17 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.16 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.16 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.18 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.19 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.23 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.23 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.24 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.25 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.25 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.24 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.24 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.23 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.23 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.23 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.23 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.22 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.25 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.26 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.27 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.25 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.34 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.39 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.39 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.39 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.42 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.42 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.42 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.4 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.41 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.36 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.33 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.28 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.28 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.28 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.27 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.3 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.3 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.29 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.29 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.28 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.17 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.17 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.17 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.17 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.16 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.17 ethambutol
embB 4248382 c.1869C>G synonymous_variant 0.15 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.15 ethambutol
embB 4249369 c.2856T>C synonymous_variant 0.16 ethambutol
embB 4249375 c.2862G>C synonymous_variant 0.17 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.2 ethambutol
embB 4249384 c.2871G>T synonymous_variant 0.2 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.22 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.21 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.21 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.19 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.2 ethambutol
embB 4249444 c.2931T>C synonymous_variant 0.22 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.24 ethambutol
embB 4249462 c.2949G>A synonymous_variant 0.74 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.25 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.24 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.24 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.19 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.18 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.18 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.18 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.17 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.17 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.16 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.16 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.17 ethambutol
aftB 4267274 c.1563G>C synonymous_variant 0.16 ethambutol
aftB 4267289 p.Ala516Glu missense_variant 0.17 ethambutol Uncertain significance
aftB 4267297 c.1540T>C synonymous_variant 0.18 ethambutol
aftB 4267301 c.1536C>T synonymous_variant 0.19 ethambutol
aftB 4267304 p.Val511Ala missense_variant 0.18 ethambutol
aftB 4267325 c.1512G>C synonymous_variant 0.17 ethambutol
aftB 4267334 c.1503T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R