TB-Profiler result

Run: ERR4816559
Summary

Run ID: ERR4816559

Sample name:

Date: 2024-04-14T14:25:03.608383

Number of reads: 2469225

Percentage reads mapped: 65.67

Median coverage: 57.0

Strain: lineage4.4.1.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.4.1 Euro-American (S-type) None 0.91
lineage4 Euro-American None 0.97
lineage4.4.1.1 Euro-American None 0.98
lineage4.4 Euro-American None 0.94
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ile491Phe Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Ile Assoc w R
p.His312Arg Mutation from literature
pyrazinamide pncA p.His51Asp Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.604_606delTCGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.24 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761277 p.Ile491Phe missense_variant 0.6 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.76 streptomycin Assoc w R
fbiC 1303534 c.604_606delTCGinsGC frameshift_variant&missense_variant 0.24 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155168 p.Ser315Thr missense_variant 0.95 isoniazid Assoc w R High-level resistance
pncA 2289091 p.His51Asp missense_variant 1.0 pyrazinamide Assoc w R
embB 4247431 p.Met306Ile missense_variant 0.79 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.24 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 720 c.720G>A synonymous_variant 0.21 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 897 c.897A>G synonymous_variant 0.26 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.26 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.26 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.28 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.27 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.26 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.27 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.25 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.21 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.23 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.28 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.2 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.22 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.22 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.22 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.24 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.21 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.22 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.23 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.23 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1245 c.1245G>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.24 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.24 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.18 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.18 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.19 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.19 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.18 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.18 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.19 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.18 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 1392 c.1392A>G synonymous_variant 0.18 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.18 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.2 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.2 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.27 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.29 isoniazid
dnaA 1461 c.1461C>G synonymous_variant 0.29 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.24 isoniazid
gyrB 6292 c.1053G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7739 c.438C>T synonymous_variant 0.24 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7763 c.462T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8121 c.820T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8264 c.963T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.18 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8357 c.1056G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8579 p.Asp426Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>A synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9104 c.1803C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9138 p.Gln613Glu missense_variant 0.73 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9143 c.1842T>C synonymous_variant 0.26 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 c.2007C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9312 c.2011C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9317 c.2016G>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9398 c.2097T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
Rv0010c 13909 c.-351G>C upstream_gene_variant 0.2 isoniazid
fgd1 490782 c.-1G>C upstream_gene_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490797 c.15G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.31 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490854 c.72C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491296 p.Val172Ile missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491307 c.525C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491325 c.543G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491607 c.825G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491613 c.831C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.18 clofazimine
pretomanid
delamanid
mshA 575674 c.327G>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.16 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.21 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.17 ethionamide
isoniazid
mshA 575771 p.Val142Phe missense_variant 0.16 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.29 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.29 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.27 ethionamide
isoniazid Not assoc w R - Interim
mshA 575884 c.537G>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.24 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>A upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619594 c.-297G>T upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>T upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>A synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
Rv0565c 656052 c.1419A>C synonymous_variant 0.16 ethionamide
Rv0565c 656112 c.1359C>G synonymous_variant 0.18 ethionamide
Rv0565c 656219 p.His418Tyr missense_variant 0.15 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.16 ethionamide
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.17 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.2 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.19 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.17 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.16 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.21 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.27 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.26 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.25 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.24 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.23 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.16 ethionamide
hadA 732305 p.Ile126Val missense_variant 0.17 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.19 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.2 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.23 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.22 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.2 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.2 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.18 isoniazid
nusG 734376 c.123G>A synonymous_variant 0.2 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.23 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.3 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.29 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.32 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.29 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.3 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.26 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.29 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.29 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.29 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.26 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.23 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.22 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.16 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760181 c.375T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.25 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.24 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.23 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.23 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.22 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.33 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.35 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.32 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.35 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.33 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.2 rifampicin Uncertain significance
rpoB 760533 p.Val243Ile missense_variant 0.16 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.23 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.26 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.34 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.29 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.31 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.17 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.23 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.29 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.4 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.35 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.43 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.39 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.37 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.42 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.44 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.38 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.38 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.38 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.36 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.35 rifampicin
rpoB 761373 p.Val523His missense_variant 0.27 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.2 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761492 c.1686G>C synonymous_variant 0.16 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.22 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.37 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.4 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.41 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.34 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.29 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.19 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.2 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.2 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.18 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.18 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.39 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.3 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.33 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.31 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.31 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.27 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.34 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.38 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.37 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.38 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.41 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.3 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.3 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.28 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.29 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.21 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.2 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.25 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.23 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.21 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.24 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.18 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.24 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.24 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.24 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.23 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.24 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.24 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.17 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.29 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.28 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.29 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.21 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.23 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.16 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.2 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.29 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.33 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.27 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.33 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.34 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.32 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.32 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.29 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.28 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.18 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.18 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.23 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.21 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.23 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.2 rifampicin
rpoC 763877 c.508_510delCTAinsTG frameshift_variant&stop_gained 0.19 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.23 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.23 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.22 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.23 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.21 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.23 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.25 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.22 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.22 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.25 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.2 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.15 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.2 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.18 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.28 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.4 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.42 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.43 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.42 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.25 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.25 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.24 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.24 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.27 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.29 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.38 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.44 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.41 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.37 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.39 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.39 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.34 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.42 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.34 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.3 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.27 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.2 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.19 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.19 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.23 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.29 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.26 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.25 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.22 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.38 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.31 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.3 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.3 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.3 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.27 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.25 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.31 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.35 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.35 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.34 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.32 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.3 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.29 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.38 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.36 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.3 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.24 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.27 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.28 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.28 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.25 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.25 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.27 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.28 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.19 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.17 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.26 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.3 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.33 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.35 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.35 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.35 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.35 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.31 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.31 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.37 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.35 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.36 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.36 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.36 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.35 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.31 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.28 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.26 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.27 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.27 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.17 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.18 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.18 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.31 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.29 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.37 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.34 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.31 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.26 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.36 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.44 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.42 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.41 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.4 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.37 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.29 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.24 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.21 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777416 c.1065G>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.2 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.19 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.2 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.21 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.21 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.26 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.28 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.24 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.24 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.28 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.28 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.27 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.28 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.28 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.29 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.29 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.28 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.22 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.21 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.19 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.21 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.18 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.21 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.26 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.22 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 800612 c.-197A>G upstream_gene_variant 0.19 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.17 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.19 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.17 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.17 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.16 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.16 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.22 linezolid
rplC 800792 c.-17G>A upstream_gene_variant 0.16 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.17 linezolid
rplC 800814 c.6A>G synonymous_variant 0.19 linezolid
rplC 800817 c.9A>T synonymous_variant 0.19 linezolid
rplC 801357 c.549T>C synonymous_variant 0.18 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.24 linezolid
rplC 801402 c.594T>C synonymous_variant 0.23 linezolid
rplC 801405 c.597T>C synonymous_variant 0.24 linezolid
rplC 801427 p.Met207Val missense_variant 0.17 linezolid
rplC 801438 c.630T>C synonymous_variant 0.2 linezolid
rplC 801442 p.Ile212Val missense_variant 0.21 linezolid
fbiC 1303497 c.567G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303501 c.571C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303866 p.Glu312Asp missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304132 p.Ala401Gly missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304161 p.Arg411Ser missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304187 c.1257T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304535 c.1605G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304727 c.1797A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.5 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
atpE 1460816 c.-229T>C upstream_gene_variant 0.22 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.26 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.24 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.24 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.25 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.23 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.23 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.21 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
inhA 1673916 c.-286A>C upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.22 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.22 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674601 p.Leu134Met missense_variant 0.16 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.17 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674828 c.627G>A synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.21 ethionamide
isoniazid
inhA 1674864 c.663C>T synonymous_variant 0.2 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.16 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.2 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.4 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834262 p.Ser241Thr missense_variant 0.16 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.39 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.23 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.29 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.33 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.3 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.31 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.16 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.17 linezolid
tsnR 1853370 c.-236G>T upstream_gene_variant 0.16 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.18 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.2 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.18 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.17 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064903 c.-175G>A upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064912 c.-184A>G upstream_gene_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064915 c.-187G>C upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064949 c.-221G>T upstream_gene_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101768 c.1275C>A synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>G synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2101951 c.1092C>T synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101963 c.1080G>A synonymous_variant 0.18 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Asp missense_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101993 c.1050A>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102218 c.825C>A synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102227 c.816C>T synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102230 c.813G>C synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.26 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102302 c.741G>C synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102990 p.Val18Ala missense_variant 1.0 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Not assoc w R
katG 2155680 c.432G>C synonymous_variant 0.2 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.19 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.2 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.24 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.24 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.24 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.22 isoniazid
PPE35 2168479 p.Thr712Pro missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169840 p.Gly258Asp missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289987 c.-746C>T upstream_gene_variant 0.25 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.22 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.22 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.23 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.22 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.3 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.23 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.22 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.17 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.2 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.2 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.23 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.22 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.21 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.19 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.2 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.19 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.2 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.19 isoniazid
kasA 2518496 c.382C>T synonymous_variant 0.78 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.22 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.22 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.19 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.18 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.23 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.23 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.2 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.16 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.19 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.2 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.22 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.24 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.26 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.23 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.25 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.25 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.28 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.3 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.3 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.24 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.25 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.25 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.28 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.18 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.19 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.19 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.15 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.19 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.18 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.21 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.23 isoniazid
kasA 2518993 c.879C>G synonymous_variant 0.22 isoniazid
kasA 2518999 c.885G>C synonymous_variant 0.22 isoniazid
kasA 2519008 c.894C>G synonymous_variant 0.22 isoniazid
kasA 2519017 c.903G>C synonymous_variant 0.19 isoniazid
kasA 2519020 c.906G>C synonymous_variant 0.2 isoniazid
kasA 2519021 p.Ala303Lys missense_variant 0.21 isoniazid
kasA 2519027 c.913_915delATCinsGT frameshift_variant&missense_variant 0.19 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.18 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.37 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.29 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.21 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.22 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.26 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.24 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ahpC 2726687 c.495C>G synonymous_variant 0.28 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.27 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.28 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.18 isoniazid
Rv2477c 2782450 c.1593C>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782513 c.1530G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782546 c.1497C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.27 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.38 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064914 c.1278T>G synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064956 c.1234_1236delAGTinsCC frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064962 c.1230C>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064973 p.Ala407Ser missense_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064995 c.1197C>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065007 c.1185G>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065013 c.1179G>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065018 p.Asn392His missense_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065022 p.Pro390Leu missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065028 c.1162_1164delGTGinsAC frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065040 c.1152C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065052 c.1140G>A synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065055 c.1137T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065082 c.1110G>T synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065262 c.930G>A synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065268 c.924A>G synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065311 p.Thr294Met missense_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066074 c.118C>T synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066102 c.90C>T synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066309 c.-118T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066315 c.-124C>T upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066330 c.-139G>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066855 c.-664T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067316 c.630A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067388 c.558C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.19 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.32 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.27 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.26 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.24 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.24 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.26 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.19 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.18 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.22 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067736 c.208_210delTTCinsCT frameshift_variant&missense_variant 0.17 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067754 c.192C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.16 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.18 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073824 c.648A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073836 c.636C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.27 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.31 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAG frameshift_variant&missense_variant 0.19 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.26 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074254 p.His73Arg missense_variant 0.17 para-aminosalicylic_acid
thyA 3074262 c.210T>C synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448522 p.Val7Phe missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3448608 c.105G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
whiB7 3568779 c.-100T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
Rv3236c 3612665 p.Val151Ala missense_variant 1.0 pyrazinamide Not assoc w R
lpqB 3624077 c.834G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624082 c.829A>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624086 c.825C>T synonymous_variant 0.19 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624092 c.817_819delAGGinsCC frameshift_variant&missense_variant 0.19 bedaquiline
rifampicin Uncertain significance
lpqB 3624100 c.811T>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624101 c.810C>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.19 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624143 c.768T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624638 c.273C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624646 c.265T>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624671 c.238_240delGCCinsTG frameshift_variant&missense_variant 0.25 bedaquiline
rifampicin Uncertain significance
lpqB 3624680 c.231T>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.22 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.27 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.156A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624783 p.Ser43Thr missense_variant 0.17 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625510 c.-600T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.21 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.2 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625633 c.981C>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625636 c.978C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.25 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.3 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.39 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626155 c.457_459delGCGinsTC frameshift_variant&missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626158 c.456C>T synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3626170 c.444T>C synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.25 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626900 c.-287G>A upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626945 c.-332C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627065 c.-452G>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627254 c.-641C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.22 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.15 bedaquiline
rifampicin
fbiB 3640878 c.-657T>C upstream_gene_variant 0.19 clofazimine
pretomanid
delamanid
rpoA 3877553 p.Glu319Gln missense_variant 0.24 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.3 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.3 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.27 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.26 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.28 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.32 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.32 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.3 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.32 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.28 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.25 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.27 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.27 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.22 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.19 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.18 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.19 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.2 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.19 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.18 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.17 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.16 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.16 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.17 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.2 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.22 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>A synonymous_variant 0.22 rifampicin
rpoA 3878172 c.336G>C synonymous_variant 0.22 rifampicin
rpoA 3878175 c.333G>C synonymous_variant 0.21 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.22 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.24 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.26 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.3 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.26 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.34 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.31 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.31 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.39 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.33 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.32 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.3 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.29 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.28 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.28 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.31 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.35 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.35 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.34 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.28 rifampicin
rpoA 3878463 c.45C>A synonymous_variant 0.26 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.28 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.24 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.23 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.25 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.27 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878725 c.-218A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.25 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.24 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.26 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.3 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.34 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.35 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.44 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.38 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.39 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.45 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878890 c.-383C>G upstream_gene_variant 0.33 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878932 c.-425G>A upstream_gene_variant 0.35 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.35 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.4 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.39 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.39 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.43 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.43 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.4 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.39 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.31 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.29 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.26 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.23 delamanid
pretomanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986646 c.-198_-196delCTCinsTG upstream_gene_variant 0.2 delamanid
pretomanid
clpC1 4038255 p.Val817Lys missense_variant 0.16 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.18 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.18 pyrazinamide
clpC1 4038275 c.2430A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.28 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.21 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.16 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.17 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.17 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.25 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.18 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.33 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.34 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.22 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.22 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.23 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.24 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.29 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.21 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.29 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.31 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.24 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.17 pyrazinamide
panD 4044758 c.-477C>T upstream_gene_variant 0.19 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.27 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.29 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.29 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.31 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.27 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.25 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.27 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.27 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.27 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.25 pyrazinamide
panD 4044860 c.-579C>G upstream_gene_variant 0.17 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.2 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.2 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.22 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.21 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.17 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.17 pyrazinamide
glpK 4138598 c.1158G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139073 p.Leu228Pro missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139143 c.613T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.572dupG frameshift_variant 0.71 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139581 p.Asn59Asp missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4238963 c.-900C>T upstream_gene_variant 0.98 ethambutol Not assoc w R
embC 4240780 c.918T>C synonymous_variant 0.33 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.32 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.3 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.25 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.25 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.26 ethambutol
embC 4241013 p.Met384Thr missense_variant 0.18 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.2 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.24 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.26 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.28 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.26 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.28 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.27 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.28 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.28 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.27 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.24 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.22 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.22 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.22 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.22 ethambutol
embC 4241179 c.1317G>A synonymous_variant 0.21 ethambutol
embC 4241383 c.1521G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4241394 p.Lys511Ser missense_variant 0.18 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.25 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.24 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.21 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.2 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.2 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.21 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.15 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.18 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.18 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.19 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.19 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.21 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.2 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.2 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.18 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.96 ethambutol Not assoc w R
embC 4242710 c.2848_2850delCAGinsGA frameshift_variant&missense_variant 0.21 ethambutol
embC 4242715 c.2853T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embA 4242742 c.-491C>G upstream_gene_variant 0.19 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.2 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.2 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.21 ethambutol
embA 4242772 c.-461G>C upstream_gene_variant 0.21 ethambutol
embA 4244498 c.1266A>G synonymous_variant 0.24 ethambutol
embA 4244507 c.1275G>T synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embA 4244508 c.1276T>C synonymous_variant 0.22 ethambutol
embA 4244516 c.1284G>C synonymous_variant 0.24 ethambutol
embA 4244517 p.Leu429Val missense_variant 0.26 ethambutol
embA 4244523 p.Pro431Ala missense_variant 0.26 ethambutol
embA 4244534 c.1302T>C synonymous_variant 0.21 ethambutol
embA 4244537 c.1305T>G synonymous_variant 0.24 ethambutol
embA 4244543 c.1311C>G synonymous_variant 0.23 ethambutol
embA 4244547 p.Ile439Val missense_variant 0.23 ethambutol
embA 4244582 c.1350T>C synonymous_variant 0.19 ethambutol
embA 4244585 c.1353A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embA 4245083 c.1851A>C synonymous_variant 0.24 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.28 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.28 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.32 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.38 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.38 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.39 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.36 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.36 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.33 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.34 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.33 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.3 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.33 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.31 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embA 4245282 p.Ile684Val missense_variant 0.2 ethambutol
embA 4245285 c.2053T>C synonymous_variant 0.19 ethambutol
embA 4245290 c.2058C>G synonymous_variant 0.19 ethambutol
embA 4245293 c.2061T>G synonymous_variant 0.19 ethambutol
embA 4245296 c.2064G>C synonymous_variant 0.19 ethambutol
embA 4245299 c.2067A>G synonymous_variant 0.19 ethambutol
embA 4245315 p.Val695Thr missense_variant 0.19 ethambutol
embA 4245693 p.Ile821Val missense_variant 0.21 ethambutol
embB 4245701 c.-813G>C upstream_gene_variant 0.22 ethambutol
embB 4245704 c.-810G>C upstream_gene_variant 0.22 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.23 ethambutol
embB 4245726 c.-788T>C upstream_gene_variant 0.23 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.22 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.22 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.2 ethambutol
embB 4245851 c.-663G>C upstream_gene_variant 0.16 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.16 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.17 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.19 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.19 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.19 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.22 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.25 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.27 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.29 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.3 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.31 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.25 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.19 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.21 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.22 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.23 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.31 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.32 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.35 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.33 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.32 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.3 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.27 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.25 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.24 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.22 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.2 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.2 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.22 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247746 c.1233C>T synonymous_variant 0.2 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.23 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.25 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.27 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.3 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.3 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.3 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.32 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.31 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.26 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.23 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.25 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.24 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.22 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.23 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.25 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.21 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.17 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.18 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.17 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.17 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.16 ethambutol Uncertain significance
embB 4248070 c.1557T>C synonymous_variant 0.23 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.31 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.36 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.36 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.36 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.36 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.35 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.3 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.3 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.29 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.29 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.33 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.28 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.23 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.23 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.18 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.17 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.16 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.19 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.19 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.27 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.27 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.28 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.28 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.26 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.28 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.29 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.29 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.33 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.29 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.28 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.3 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.32 ethambutol Uncertain significance
aftB 4267604 c.1233C>G synonymous_variant 0.18 ethambutol
aftB 4267607 c.1230G>A synonymous_variant 0.17 ethambutol
aftB 4267625 c.1212T>C synonymous_variant 0.19 ethambutol
aftB 4267628 c.1209C>G synonymous_variant 0.19 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.17 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.19 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.23 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.2 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.19 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.2 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.2 ethambutol
aftB 4268186 c.651C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
aftB 4268193 p.Leu215Ala missense_variant 0.22 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.21 ethambutol
aftB 4268602 p.Leu79Met missense_variant 0.36 ethambutol
aftB 4268608 p.Met77Leu missense_variant 0.4 ethambutol
aftB 4268612 c.225G>C synonymous_variant 0.4 ethambutol
aftB 4268618 c.219G>C synonymous_variant 0.4 ethambutol
aftB 4268626 p.Gly71Ser missense_variant 0.38 ethambutol
aftB 4268630 p.Val69Ala missense_variant 0.35 ethambutol
aftB 4268633 c.204T>C synonymous_variant 0.3 ethambutol
aftB 4268638 p.Leu67Met missense_variant 0.28 ethambutol
aftB 4268642 c.195T>C synonymous_variant 0.27 ethambutol
aftB 4268651 c.186G>C synonymous_variant 0.27 ethambutol
aftB 4268654 c.183A>C synonymous_variant 0.26 ethambutol
aftB 4268657 c.180G>C synonymous_variant 0.25 ethambutol
aftB 4268666 c.171G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
aftB 4268669 c.168A>G synonymous_variant 0.24 ethambutol
aftB 4268675 c.162A>G synonymous_variant 0.24 ethambutol
aftB 4269006 c.-170T>C upstream_gene_variant 0.2 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.19 ethambutol
ubiA 4269027 c.807C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4269036 c.-200C>G upstream_gene_variant 0.17 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin