TB-Profiler result

Run: ERR4819546
Summary

Run ID: ERR4819546

Sample name:

Date: 2024-10-04T14:50:23.139456

Number of reads: 669782

Percentage reads mapped: 37.62

Median coverage: 17.0

Strain: lineage3

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.349dupG Assoc w R High-level resistance
c.344delT Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155762 c.349dupG frameshift_variant 0.48 isoniazid Assoc w R High-level resistance
katG 2155767 c.344delT frameshift_variant 0.48 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 567 c.567C>G synonymous_variant 0.32 isoniazid
dnaA 573 p.Leu191Phe missense_variant 0.29 isoniazid Uncertain significance
dnaA 577 p.Ile193Val missense_variant 0.29 isoniazid Uncertain significance
dnaA 582 c.582A>G synonymous_variant 0.28 isoniazid
dnaA 588 c.588A>G synonymous_variant 0.28 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.28 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.26 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.24 isoniazid
dnaA 612 c.612G>C synonymous_variant 0.23 isoniazid
dnaA 633 c.633T>G synonymous_variant 0.23 isoniazid
gyrB 5079 c.-161G>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6181 c.942C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.39 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8305 p.Thr335Ser missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8366 c.1065G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>T synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 8894 c.1593C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8934 p.Gln545Lys missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8944 p.Gly548Asp missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
nusG 734424 c.171G>C synonymous_variant 0.21 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.37 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.38 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
nusG 734463 c.210G>C synonymous_variant 0.46 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.49 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>C synonymous_variant 0.54 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
nusG 734543 p.Arg97Gln missense_variant 0.47 rifampicin
nusG 734549 p.Gln99Arg missense_variant 0.47 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.46 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.47 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.38 rifampicin
nusG 734596 c.343_345delTTGinsCTC synonymous_variant 0.26 rifampicin
nusG 734600 p.Thr116Asn missense_variant 0.26 rifampicin Uncertain significance
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760223 c.417T>C synonymous_variant 0.39 rifampicin
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.35 rifampicin
rpoB 760241 c.435G>C synonymous_variant 0.34 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760262 c.456G>C synonymous_variant 0.29 rifampicin
rpoB 760271 c.465C>G synonymous_variant 0.31 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.29 rifampicin Uncertain significance
rpoB 760298 c.492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Asn missense_variant 0.21 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.33 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.34 rifampicin Uncertain significance
rpoB 760380 p.Thr192Pro missense_variant 0.34 rifampicin
rpoB 760394 c.588C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760400 c.594G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760407 p.Ser201Ala missense_variant 0.53 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760469 c.663C>T synonymous_variant 0.48 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.48 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.57 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Leu missense_variant 0.56 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760553 c.747C>G synonymous_variant 0.56 rifampicin
rpoB 760565 c.759A>G synonymous_variant 0.61 rifampicin
rpoB 760568 c.762G>C synonymous_variant 0.53 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.51 rifampicin
rpoB 760589 c.783C>G synonymous_variant 0.59 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.6 rifampicin
rpoB 760611 c.805_807delTTGinsCTC synonymous_variant 0.61 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.59 rifampicin
rpoB 760652 c.846C>G synonymous_variant 0.59 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.61 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761058 p.Val418Ser missense_variant 0.69 rifampicin
rpoB 761063 c.1257C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.59 rifampicin
rpoB 761096 c.1290G>C synonymous_variant 0.59 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.59 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.59 rifampicin
rpoB 761111 c.1305C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761162 c.1356G>C synonymous_variant 0.68 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>G synonymous_variant 0.67 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.75 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761288 c.1482G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.67 rifampicin
rpoB 761549 c.1743G>C synonymous_variant 0.38 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761933 c.2127G>C synonymous_variant 0.56 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.54 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.54 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.54 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762032 c.2226C>G synonymous_variant 0.53 rifampicin
rpoB 762035 c.2229G>C synonymous_variant 0.57 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762074 c.2268C>G synonymous_variant 0.45 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.45 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.54 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.57 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.57 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.54 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.71 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>C synonymous_variant 0.57 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.48 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.3 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 762879 p.Met1025Leu missense_variant 0.44 rifampicin Uncertain significance
rpoB 762905 p.Asp1033Glu missense_variant 0.53 rifampicin
rpoC 762917 c.-453C>A upstream_gene_variant 0.51 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.53 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.56 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.61 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.59 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763052 c.-318G>C upstream_gene_variant 0.74 rifampicin
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.74 rifampicin
rpoC 763067 c.-303C>G upstream_gene_variant 0.74 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.74 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.63 rifampicin
rpoC 763160 c.-210G>C upstream_gene_variant 0.42 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.37 rifampicin
rpoB 763172 c.3366G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763507 c.138G>C synonymous_variant 0.58 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.68 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.68 rifampicin
rpoC 763660 c.291T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.6 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.56 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.57 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.64 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.63 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.61 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.51 rifampicin
rpoC 763781 p.Ser138Glu missense_variant 0.43 rifampicin
rpoC 763796 p.Met143Gln missense_variant 0.41 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763812 p.Leu148Gln missense_variant 0.33 rifampicin
rpoC 764147 p.Ser260Ala missense_variant 0.5 rifampicin Uncertain significance
rpoC 764153 p.Gln262Lys missense_variant 0.6 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.63 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.74 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.71 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.71 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.71 rifampicin
rpoC 764216 p.Asn283Ser missense_variant 0.71 rifampicin
rpoC 764239 c.870T>C synonymous_variant 0.75 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.74 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.61 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.61 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.46 rifampicin
rpoC 764308 c.939G>C synonymous_variant 0.48 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.4 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.44 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.46 rifampicin
rpoC 764404 c.1035C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.44 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.42 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.43 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.43 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.47 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.63 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.67 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.67 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>G synonymous_variant 0.72 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.68 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>A synonymous_variant 0.67 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.7 rifampicin
rpoC 764755 c.1386C>T synonymous_variant 0.68 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.68 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.65 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.67 rifampicin
rpoC 764809 c.1440C>G synonymous_variant 0.68 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.65 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764854 c.1485G>C synonymous_variant 0.6 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.61 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.62 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.57 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.45 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.44 rifampicin Uncertain significance
rpoC 764917 c.1548G>C synonymous_variant 0.44 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.44 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.43 rifampicin
rpoC 764948 c.1579_1581delTTGinsCTC synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.41 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.5 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765544 c.2175C>G synonymous_variant 0.56 rifampicin
rpoC 765547 c.2178C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.53 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.56 rifampicin
rpoC 765569 p.Ala734Ser missense_variant 0.53 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.43 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.43 rifampicin
rpoC 765590 p.Arg741Ser missense_variant 0.36 rifampicin Uncertain significance
rpoC 765601 p.Glu744Asp missense_variant 0.29 rifampicin
rpoC 765612 p.His748Arg missense_variant 0.27 rifampicin
rpoC 765844 c.2475C>G synonymous_variant 0.42 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.43 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.48 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.54 rifampicin
rpoC 765955 c.2586C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>T synonymous_variant 0.5 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.5 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.33 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766351 c.2982C>G synonymous_variant 0.32 rifampicin
rpoC 766357 c.2988C>T synonymous_variant 0.29 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.3 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.3 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.29 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.27 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.27 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.35 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766813 c.3444G>C synonymous_variant 0.41 rifampicin
rpoC 766835 p.Val1156Thr missense_variant 0.44 rifampicin
rpoC 766843 c.3474T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766990 c.3621G>C synonymous_variant 0.54 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781760 c.201T>C synonymous_variant 0.35 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.38 streptomycin
rpsL 781781 c.222G>T synonymous_variant 0.47 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.5 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.52 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.52 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.53 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.51 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.59 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.61 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.65 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.61 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.59 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.61 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.59 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.59 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.56 streptomycin
rpsL 781901 c.342C>G synonymous_variant 0.57 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.53 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.49 streptomycin
Rv1129c 1254557 c.-23C>A upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
rrs 1471710 n.-136T>C upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.87 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.87 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.83 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471981 n.136C>T non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472396 n.551A>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>G non_coding_transcript_exon_variant 0.95 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473082 n.1237G>C non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>G non_coding_transcript_exon_variant 0.87 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473130 n.1285G>C non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473695 n.38A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>A non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1473793 n.136G>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1473797 n.140G>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1473802 n.145C>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473870 n.213G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474127 n.470G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524_530delCCTCGATinsACCTTGC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474505 n.848C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474674 n.1017A>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474675 n.1018C>A non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474718 n.1061_1062delAGinsGTGAGAA non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474822 n.1165G>C non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474896 n.1239A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475688 n.2031G>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2102delACinsG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475768 n.2111_2112delGTinsC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833676 c.135A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.4 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.4 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.58 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.62 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.67 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.69 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.67 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.68 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.63 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.67 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.66 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.66 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.64 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.61 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.62 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834298 p.Gln253Thr missense_variant 0.55 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.46 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.42 pyrazinamide Uncertain significance
rpsA 1834345 c.804C>T synonymous_variant 0.44 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834384 c.843A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834387 c.846C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.37 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.55 pyrazinamide
rpsA 1834456 c.915T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.59 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834556 p.Ala339Ser missense_variant 0.33 pyrazinamide
rpsA 1834573 c.1032G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.42 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834700 p.Gln387Asn missense_variant 0.46 pyrazinamide
rpsA 1834706 p.Asn389Glu missense_variant 0.46 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.54 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.54 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.57 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.57 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.42 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834788 p.Ala416Gly missense_variant 0.44 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834804 c.1263C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834813 c.1272G>C synonymous_variant 0.36 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155674 c.438G>C synonymous_variant 0.5 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.53 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.6 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.6 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.5 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.54 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.52 isoniazid
katG 2155736 p.Met126Leu missense_variant 0.5 isoniazid
katG 2155740 p.Gly124Ala missense_variant 0.48 isoniazid Uncertain significance
katG 2155743 c.369G>C synonymous_variant 0.48 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.5 isoniazid
katG 2155752 c.360C>T synonymous_variant 0.5 isoniazid
katG 2155755 c.357C>T synonymous_variant 0.5 isoniazid Not assoc w R - Interim
katG 2155785 p.Ala109Ser missense_variant 0.44 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
kasA 2517921 c.-194_-193delACinsCT upstream_gene_variant 0.39 isoniazid
kasA 2517945 c.-170_-168delATCinsGTG upstream_gene_variant 0.27 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
ahpC 2726636 c.444G>C synonymous_variant 0.18 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.18 isoniazid
ahpC 2726651 c.459G>C synonymous_variant 0.19 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.24 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.23 isoniazid
ahpC 2726678 c.486G>C synonymous_variant 0.26 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ahpC 2726687 c.495C>G synonymous_variant 0.25 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.23 isoniazid
ahpC 2726717 c.525A>C synonymous_variant 0.24 isoniazid
Rv2477c 2782482 p.Lys521Gln missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782484 p.Ala520Gly missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782490 p.Asn518Ser missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782493 p.Asp517Val missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782497 p.Asp516Asn missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2782528 c.1515G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782531 c.1512C>T synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782537 c.1506T>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrA 3627068 c.282T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627086 c.-473C>G upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrA 3627094 p.Thr86Ala missense_variant 0.36 rifampicin
bedaquiline
mtrB 3627098 c.-485A>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrA 3627118 c.230_231delTT frameshift_variant 0.28 rifampicin
bedaquiline
mtrA 3627125 c.224_225insGT frameshift_variant 0.28 rifampicin
bedaquiline
mtrB 3627139 c.-526T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627143 c.-530G>C upstream_gene_variant 0.32 rifampicin
bedaquiline
fbiB 3642597 p.Asp355Asn missense_variant 1.0 pretomanid
delamanid
clofazimine
rpoA 3877587 p.Ser307Ala missense_variant 0.41 rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877600 p.Gln303Ala missense_variant 0.39 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.46 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.46 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 0.5 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877659 c.849G>T synonymous_variant 0.56 rifampicin
rpoA 3877662 c.846C>T synonymous_variant 0.56 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.58 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.54 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.46 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.47 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 0.5 rifampicin
rpoA 3877752 p.Asp252Glu missense_variant 0.53 rifampicin
rpoA 3877764 p.Ala248Ser missense_variant 0.56 rifampicin
rpoA 3877770 p.Ser246Ala missense_variant 0.56 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>C synonymous_variant 0.58 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>C synonymous_variant 0.5 rifampicin
rpoA 3877845 c.663G>C synonymous_variant 0.48 rifampicin
rpoA 3877848 c.660C>G synonymous_variant 0.48 rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.56 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.56 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877898 p.Pro204Ala missense_variant 0.5 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.49 rifampicin
rpoA 3877902 p.Ile202Met missense_variant 0.49 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877935 p.Lys191Arg missense_variant 0.47 rifampicin
rpoA 3877938 c.570C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.46 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.48 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>G synonymous_variant 0.52 rifampicin
rpoA 3877998 c.510G>C synonymous_variant 0.52 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.37 rifampicin
rpoA 3878013 c.495T>C synonymous_variant 0.38 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.38 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.38 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.3 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.27 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.32 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.31 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.38 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 0.44 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.42 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.42 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.44 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.42 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.43 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.43 rifampicin Uncertain significance
rpoA 3878154 c.354G>C synonymous_variant 0.4 rifampicin
rpoA 3878161 c.345_346delCG frameshift_variant 0.39 rifampicin
rpoA 3878166 c.341_342insGT frameshift_variant 0.4 rifampicin
rpoA 3878175 c.333G>C synonymous_variant 0.47 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.5 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.44 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.44 rifampicin
rpoA 3878217 p.Leu97Val missense_variant 0.51 rifampicin
rpoA 3878241 p.Glu89Asp missense_variant 0.5 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.5 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.5 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.48 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.48 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.38 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.38 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.32 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.35 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
clpC1 4038740 c.1965G>C synonymous_variant 0.62 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.71 pyrazinamide
clpC1 4038761 c.1944C>G synonymous_variant 0.71 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.71 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.73 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.76 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.77 pyrazinamide
clpC1 4038808 c.1896_1897insC frameshift_variant 0.65 pyrazinamide
clpC1 4038811 c.1893delT frameshift_variant 0.64 pyrazinamide
clpC1 4038836 c.1869G>C synonymous_variant 0.7 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.68 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4038899 c.1806C>G synonymous_variant 0.77 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.75 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.71 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.69 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.69 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.69 pyrazinamide
clpC1 4038926 c.1779G>C synonymous_variant 0.69 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.72 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.74 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.73 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4038986 p.Asp573Glu missense_variant 0.62 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.62 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.63 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.79 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.71 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.62 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.56 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.56 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCTC synonymous_variant 0.57 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.59 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.48 pyrazinamide
clpC1 4039217 c.1488G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039244 c.1461G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039250 c.1455C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039642 p.Thr355Ala missense_variant 0.71 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039652 p.Thr351Ser missense_variant 0.65 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.77 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.72 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.71 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>T synonymous_variant 0.69 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.65 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.6 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039876 p.Asn277Asp missense_variant 0.6 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039896 p.Lys270Arg missense_variant 0.55 pyrazinamide Uncertain significance
clpC1 4039898 c.807C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.35 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039994 p.Glu237Asn missense_variant 0.62 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.57 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.58 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.6 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.59 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.6 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.61 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.64 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.53 pyrazinamide
clpC1 4040108 c.597G>C synonymous_variant 0.4 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.5 pyrazinamide
clpC1 4040431 c.270_274delGAGCTinsCTCGC synonymous_variant 0.5 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.43 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.48 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.48 pyrazinamide
clpC1 4040486 c.219G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040495 c.210C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040501 c.204C>G synonymous_variant 0.45 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>A synonymous_variant 0.46 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040555 c.150G>A synonymous_variant 0.32 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040561 p.Ser48Ala missense_variant 0.31 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040573 c.132T>G synonymous_variant 0.33 pyrazinamide
clpC1 4040582 c.123G>T synonymous_variant 0.31 pyrazinamide
clpC1 4040585 c.120A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 0.25 pyrazinamide
clpC1 4040603 c.102T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040606 c.99T>C synonymous_variant 0.26 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R