TB-Profiler result

Run: SRR5153091
Summary

Run ID: SRR5153091

Sample name:

Date: 2024-10-05T01:04:55.688574

Number of reads: 2497639

Percentage reads mapped: 42.37

Median coverage: 49.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4 Euro-American None 1.0
lineage4.3.3 Euro-American (LAM) RD115 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser140Asn Uncertain significance Mutation from literature
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155693 p.Ser140Asn missense_variant 0.29 isoniazid Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 434 p.His145Arg missense_variant 1.0 isoniazid Uncertain significance
gyrB 6298 c.1059C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6306 c.1067_1068insGAT disruptive_inframe_insertion 0.24 levofloxacin
moxifloxacin
gyrA 6310 c.-992G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6312 p.Ile358Ser missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 6313 c.1075_1077delTCG conservative_inframe_deletion 0.25 levofloxacin
moxifloxacin
gyrA 6328 c.-974C>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6334 c.-968G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6352 c.1113C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6764 p.Leu509Phe missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 6775 c.-527G>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6787 c.-515G>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6798 p.Gly520Ala missense_variant 0.22 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6802 c.1563G>A synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.22 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6835 c.-467C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6844 c.-458T>C upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8040 p.Gly247Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0565c 657449 p.Gly8Ser missense_variant 1.0 ethionamide Uncertain significance
nusG 734532 c.279A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734548 p.Gln99Ser missense_variant 0.23 rifampicin
nusG 734556 c.303C>T synonymous_variant 0.24 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.24 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.25 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760172 c.366G>C synonymous_variant 0.2 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.21 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760185 c.379C>T synonymous_variant 0.21 rifampicin
rpoB 760199 c.393C>G synonymous_variant 0.26 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.28 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>A synonymous_variant 0.23 rifampicin
rpoB 760256 c.450C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760571 c.765G>C synonymous_variant 0.18 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.15 rifampicin
rpoB 760596 p.Thr264Gln missense_variant 0.15 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761288 c.1482G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761289 p.Ser495Ala missense_variant 0.27 rifampicin
rpoB 761294 c.1488G>A synonymous_variant 0.32 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761339 c.1533C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.27 rifampicin
rpoB 761346 p.Val514Ile missense_variant 0.27 rifampicin
rpoB 761355 p.Val517Leu missense_variant 0.26 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.25 rifampicin
rpoB 761370 p.Ile522Val missense_variant 0.24 rifampicin
rpoB 761558 c.1752C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761582 c.1776G>A synonymous_variant 0.27 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.38 rifampicin
rpoB 761643 p.Val613Ile missense_variant 0.36 rifampicin Uncertain significance
rpoB 762002 c.2196C>G synonymous_variant 0.15 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.17 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762020 p.Glu738Asp missense_variant 0.14 rifampicin
rpoB 762026 c.2220G>C synonymous_variant 0.19 rifampicin
rpoB 762041 c.2235C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762068 c.2262C>T synonymous_variant 0.21 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762104 c.2298C>T synonymous_variant 0.22 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.29 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.28 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.27 rifampicin
rpoB 762161 c.2355C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762188 c.2382C>T synonymous_variant 0.31 rifampicin
rpoB 762221 c.2415G>A synonymous_variant 0.35 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.47 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.45 rifampicin
rpoB 762290 c.2484C>T synonymous_variant 0.4 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762335 c.2529C>T synonymous_variant 0.25 rifampicin
rpoC 762470 c.-900G>T upstream_gene_variant 0.26 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.46 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.6 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 762998 c.-372G>A upstream_gene_variant 0.57 rifampicin
rpoB 763004 c.3198G>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763025 c.-345C>T upstream_gene_variant 0.36 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.34 rifampicin Not assoc w R
rpoC 763049 c.-321G>A upstream_gene_variant 0.3 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.18 rifampicin
rpoC 763079 c.-291C>G upstream_gene_variant 0.18 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763124 c.-246C>T upstream_gene_variant 0.21 rifampicin
rpoC 763139 c.-231C>T upstream_gene_variant 0.18 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.17 rifampicin
rpoB 763145 c.3339G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763501 c.132C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763505 c.136C>T synonymous_variant 0.27 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.31 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.32 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.32 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.32 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763561 c.192G>A synonymous_variant 0.41 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763648 c.279C>T synonymous_variant 0.28 rifampicin
rpoC 763651 c.282C>T synonymous_variant 0.25 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764059 c.690G>T synonymous_variant 0.18 rifampicin
rpoC 764077 c.708C>G synonymous_variant 0.17 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.17 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.16 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Gln missense_variant 0.18 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.16 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.24 rifampicin
rpoC 764404 c.1035C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.27 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.34 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.33 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.51 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.52 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764680 c.1311G>A synonymous_variant 0.3 rifampicin
rpoC 764686 c.1317C>T synonymous_variant 0.31 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.29 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764779 c.1410G>A synonymous_variant 0.25 rifampicin
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.27 rifampicin
rpoC 764785 c.1416C>G synonymous_variant 0.27 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.3 rifampicin
rpoC 764809 c.1440C>G synonymous_variant 0.3 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.3 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 0.31 rifampicin
rpoC 764854 c.1485G>T synonymous_variant 0.3 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.36 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.35 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.46 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.45 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.42 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.36 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.79 rifampicin Not assoc w R
rpoC 765772 c.2403C>G synonymous_variant 0.24 rifampicin
rpoC 765781 c.2412C>T synonymous_variant 0.27 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.29 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.29 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.29 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>T synonymous_variant 0.28 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.28 rifampicin
rpoC 765820 c.2451G>C synonymous_variant 0.29 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.29 rifampicin
rpoC 765844 c.2475C>G synonymous_variant 0.46 rifampicin
rpoC 765871 c.2502T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.4 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.38 rifampicin
rpoC 765907 c.2538G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.29 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.18 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.27 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.29 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.3 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766429 c.3061_3062insCGG disruptive_inframe_insertion 0.28 rifampicin
rpoC 766435 p.Glu1022Asp missense_variant 0.24 rifampicin Uncertain significance
rpoC 766447 c.3078T>C synonymous_variant 0.23 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.17 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.15 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.16 rifampicin
rpoC 766742 p.Gln1125Met missense_variant 0.16 rifampicin
rpoC 766753 c.3384C>G synonymous_variant 0.22 rifampicin
rpoC 766754 p.Glu1129Gln missense_variant 0.22 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766776 p.Arg1136His missense_variant 0.28 rifampicin
rpoC 766799 p.Ala1144Ser missense_variant 0.33 rifampicin Uncertain significance
rpoC 766804 c.3435A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766975 c.3606C>G synonymous_variant 0.17 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.18 rifampicin
rpoC 766987 c.3618G>A synonymous_variant 0.29 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.43 rifampicin
rpoC 767065 c.3696G>A synonymous_variant 0.43 rifampicin
rpoC 767071 c.3702C>G synonymous_variant 0.47 rifampicin
rpoC 767092 c.3723C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767093 c.3724_3725delAGinsTC synonymous_variant 0.3 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767100 p.Lys1244Arg missense_variant 0.27 rifampicin
rpoC 767106 p.Asn1246Ile missense_variant 0.24 rifampicin
rpoC 767110 c.3741T>C synonymous_variant 0.26 rifampicin
rpoC 767113 c.3744G>C synonymous_variant 0.29 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.18 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.18 streptomycin
rpsL 781637 c.78C>G synonymous_variant 0.19 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.16 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.15 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.14 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.14 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.17 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.16 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.17 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.16 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.16 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>T synonymous_variant 0.16 streptomycin
rpsL 781853 c.294C>T synonymous_variant 0.19 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.16 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.16 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.15 streptomycin
fbiC 1303095 c.165G>A synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
embR 1417942 c.-595G>T upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471914 n.69A>G non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.34 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.34 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471943 n.98T>C non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471978 n.133C>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.45 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472486 n.641A>G non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>T non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.52 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsCA non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475422 n.1765A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475735 n.2078T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475760 n.2103_2110delCCGCAAGGinsGCTTCGGC non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475791 n.2134A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475892 n.2235A>G non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.4 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833571 c.30A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833580 c.39C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.15 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.15 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833607 c.66T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.17 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.16 pyrazinamide
rpsA 1833623 p.Lys28Ala missense_variant 0.17 pyrazinamide
rpsA 1833646 c.105T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833652 c.111C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833769 c.228C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833808 c.267G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.38 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.35 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833859 c.318C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.37 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.43 pyrazinamide
rpsA 1833919 c.378C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1833920 p.Lys127Arg missense_variant 0.29 pyrazinamide
rpsA 1833928 c.387G>T synonymous_variant 0.31 pyrazinamide
rpsA 1833931 c.390C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.29 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833964 c.423C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1833970 c.429G>T synonymous_variant 0.36 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.37 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.43 pyrazinamide
rpsA 1834093 c.552G>T synonymous_variant 0.29 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834117 c.576G>A synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.19 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834307 p.Asp256Thr missense_variant 0.17 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>T synonymous_variant 0.23 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834375 c.834G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.26 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.39 pyrazinamide
rpsA 1834456 c.915T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.39 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834516 c.975G>A synonymous_variant 0.44 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834557 p.Ala339Val missense_variant 0.24 pyrazinamide
rpsA 1834591 c.1050C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834597 c.1056C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834663 c.1122C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.26 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.38 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.4 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.41 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.39 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.37 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.36 pyrazinamide
rpsA 1834788 p.Ala416Gly missense_variant 0.35 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834804 c.1263C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834836 p.Met432Thr missense_variant 0.77 pyrazinamide Not assoc w R - Interim
tsnR 1853361 c.-245T>C upstream_gene_variant 0.16 linezolid
tsnR 1853372 c.-234A>G upstream_gene_variant 0.14 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.13 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.14 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2155691 c.421T>C synonymous_variant 0.36 isoniazid
katG 2155696 p.Ala139Gly missense_variant 0.35 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.33 isoniazid
katG 2156196 c.-85C>T upstream_gene_variant 0.98 isoniazid Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518919 p.Gly269Ser missense_variant 1.0 isoniazid
folC 2746340 p.Ala420Val missense_variant 1.0 para-aminosalicylic_acid
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626732 c.-119A>G upstream_gene_variant 0.12 rifampicin
bedaquiline
mtrA 3626786 p.Pro188Ala missense_variant 0.12 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3626813 c.-200C>G upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627071 c.-458G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627089 c.-476C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627125 c.-512C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627139 c.-526T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
rpoA 3877613 p.Ile299Val missense_variant 0.29 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.3 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.31 rifampicin
rpoA 3877653 c.855C>T synonymous_variant 0.31 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.32 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877674 c.834C>T synonymous_variant 0.31 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877893 c.615C>G synonymous_variant 0.17 rifampicin
rpoA 3877896 p.Pro204Ala missense_variant 0.16 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.19 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.17 rifampicin
rpoA 3877932 c.576G>C synonymous_variant 0.17 rifampicin
rpoA 3877936 p.Lys191Arg missense_variant 0.17 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.13 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.12 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.23 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.23 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.24 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.25 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.26 rifampicin Uncertain significance
rpoA 3878298 c.210A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.18 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3879058 c.-551C>G upstream_gene_variant 0.14 rifampicin
rpoA 3879079 c.-572A>T upstream_gene_variant 0.2 rifampicin
rpoA 3879088 c.-583_-581delACAinsTCC upstream_gene_variant 0.2 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.2 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.2 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4038755 c.1950G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.3 pyrazinamide
clpC1 4038770 c.1935C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.4 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.48 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.49 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038896 c.1809C>T synonymous_variant 0.32 pyrazinamide
clpC1 4038968 c.1737G>A synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039067 c.1638G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039082 c.1623C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.33 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.29 pyrazinamide
clpC1 4039178 c.1527G>T synonymous_variant 0.26 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCTC synonymous_variant 0.25 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.25 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.23 pyrazinamide
clpC1 4039217 c.1488G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039239 p.Gly489Ala missense_variant 0.22 pyrazinamide
clpC1 4039427 p.Glu426Asp missense_variant 0.21 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039436 c.1269G>A synonymous_variant 0.23 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>C synonymous_variant 0.33 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039598 c.1107C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039634 p.Glu357Asn missense_variant 0.33 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039688 c.1017G>A synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039694 c.1011G>T synonymous_variant 0.45 pyrazinamide
clpC1 4039700 c.1005C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039724 c.981A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.51 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.38 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.37 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039835 c.870C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039868 c.837C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039880 c.825G>A synonymous_variant 0.19 pyrazinamide
clpC1 4039913 c.792C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039940 c.765G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.36 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039985 c.720G>A synonymous_variant 0.37 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.31 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040027 c.678C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.2 pyrazinamide
glpK 4139015 c.741G>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R