TB-Profiler result

Run: ERR3801503
Summary

Run ID: ERR3801503

Sample name:

Date: 2024-10-04T20:24:05.284202

Number of reads: 2884238

Percentage reads mapped: 78.73

Median coverage: 138.0

Strain: lineage4.6.2.2

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.6 Euro-American None 0.99
lineage4.6.2 Euro-American RD726 0.96
lineage4.6.2.2 Euro-American (Cameroon) RD726 0.97
lineage4 Euro-American None 0.91
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1242 c.1242G>C synonymous_variant 0.2 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1314 c.1314A>G synonymous_variant 0.19 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.19 isoniazid
gyrB 6238 c.999G>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.23 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6328 c.-974C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6418 c.-884C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6583 c.-719G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6808 c.1569C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6847 c.-455C>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6889 c.-413G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6898 c.-404G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6950 c.-352_-350delCTCinsTTG upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6994 c.-308C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7057 c.-245C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7147 c.-155G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7607 c.306C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8207 c.906T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCTG synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8633 c.1332C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.2 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9179 c.1878C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9263 c.1962C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9268 p.Asn656Ser missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9345 c.2044A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9429 p.Arg710Trp missense_variant 0.16 levofloxacin
moxifloxacin
fgd1 490948 p.Ser56Ala missense_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490974 c.192T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 490980 p.Asn66Lys missense_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491064 c.282A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491083 p.Val101Ile missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Asp missense_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491196 c.414A>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.19 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491296 p.Val172Ile missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491340 c.558C>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491355 c.573C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491364 c.582T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491367 c.585G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
mshA 575771 p.Val142Ser missense_variant 0.2 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.2 isoniazid
ethionamide
ccsA 620288 p.Arg133Gln missense_variant 0.17 kanamycin
capreomycin
amikacin
hadA 732396 p.Gly156Ala missense_variant 0.19 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.19 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.2 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.2 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.23 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.24 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.18 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.23 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.23 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.22 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.2 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.22 rifampicin Not assoc w R
nusG 734661 c.408A>C synonymous_variant 0.22 rifampicin
nusG 734664 c.411T>A synonymous_variant 0.18 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.23 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734682 c.429C>G synonymous_variant 0.21 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.21 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.19 rifampicin
nusG 734726 p.Arg158Lys missense_variant 0.19 rifampicin
nusG 734733 c.480T>C synonymous_variant 0.2 rifampicin
nusG 734757 c.504T>C synonymous_variant 0.2 rifampicin
nusG 734772 c.519G>C synonymous_variant 0.19 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.18 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.18 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.2 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760340 c.534G>C synonymous_variant 0.22 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760373 c.567C>G synonymous_variant 0.18 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760430 c.624T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Ile missense_variant 0.16 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.19 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.2 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.2 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.16 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.23 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.24 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.25 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.26 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.21 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.3 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.3 rifampicin
rpoB 761132 c.1326G>A synonymous_variant 0.22 rifampicin
rpoB 761133 c.1327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.25 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.27 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761375 c.1569G>C synonymous_variant 0.26 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.3 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.31 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.31 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.31 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.28 rifampicin
rpoB 761457 p.Pro551Gly missense_variant 0.27 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.3 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.35 rifampicin
rpoB 761495 c.1689G>A synonymous_variant 0.28 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.37 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.32 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.29 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.34 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.28 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.29 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.28 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.23 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.22 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.24 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.29 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.31 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.3 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.31 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.32 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.32 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.3 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.26 rifampicin
rpoB 761816 c.2010C>G synonymous_variant 0.26 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.22 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.24 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.25 rifampicin
rpoB 761867 c.2061C>T synonymous_variant 0.2 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.26 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.27 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.22 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.22 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.22 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.22 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.27 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>G synonymous_variant 0.2 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.27 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.2 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.22 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.3 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.23 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.3 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.3 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.28 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.27 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.26 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.26 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.19 rifampicin
rpoC 762389 c.-981G>A upstream_gene_variant 0.18 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.18 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.23 rifampicin
rpoB 762401 c.2595G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.28 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.23 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.23 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.18 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.2 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.2 rifampicin
rpoB 762630 p.Ala942Thr missense_variant 0.17 rifampicin Uncertain significance
rpoC 762701 c.-669T>C upstream_gene_variant 0.19 rifampicin
rpoC 762728 c.-642C>G upstream_gene_variant 0.2 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762759 p.Cys985Ala missense_variant 0.19 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.24 rifampicin Uncertain significance
rpoC 762791 c.-579G>C upstream_gene_variant 0.2 rifampicin
rpoB 762795 p.Asp997Asn missense_variant 0.2 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.25 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.27 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762868 p.Tyr1021Phe missense_variant 0.24 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.27 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.3 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763250 c.-120C>T upstream_gene_variant 0.2 rifampicin
rpoC 763253 c.-117G>C upstream_gene_variant 0.2 rifampicin
rpoC 763352 c.-18T>A upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoC 763411 c.42T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.23 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.26 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.32 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.33 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.24 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.32 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.32 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.27 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.35 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.26 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.38 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.3 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.26 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.33 rifampicin
rpoC 763851 p.Ala161Gly missense_variant 0.21 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.27 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.27 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.3 rifampicin
rpoC 763876 c.507A>G synonymous_variant 0.25 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.29 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.25 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.31 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.26 rifampicin
rpoC 763948 c.579G>C synonymous_variant 0.26 rifampicin
rpoC 763963 c.594C>G synonymous_variant 0.26 rifampicin
rpoC 763978 c.609C>T synonymous_variant 0.26 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.3 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.31 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.33 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.28 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.32 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.31 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.32 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764099 p.Leu244Ile missense_variant 0.29 rifampicin
rpoC 764110 c.741C>G synonymous_variant 0.27 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.29 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.21 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.2 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.2 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.19 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>C synonymous_variant 0.22 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.23 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.22 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.22 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.22 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.18 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.27 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>G synonymous_variant 0.23 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.21 rifampicin
rpoC 764714 c.1345C>T synonymous_variant 0.21 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.21 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.27 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.2 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.19 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.2 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.2 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.2 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.25 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.25 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.3 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.28 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.29 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.26 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.32 rifampicin
rpoC 765592 c.2223C>T synonymous_variant 0.25 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765694 c.2325G>C synonymous_variant 0.25 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365_2367delTTGinsCTC synonymous_variant 0.3 rifampicin
rpoC 765739 c.2370G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765753 p.Asp795Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.32 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.32 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.31 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.31 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.26 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>C synonymous_variant 0.26 rifampicin
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.28 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.28 rifampicin
rpoC 766081 c.2712T>C synonymous_variant 0.2 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.2 rifampicin
rpoC 766087 c.2718C>G synonymous_variant 0.19 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.19 rifampicin
rpoC 766141 c.2772C>T synonymous_variant 0.19 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766178 p.Ile937Val missense_variant 0.18 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.18 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.17 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.18 rifampicin
rpoC 766297 c.2928G>C synonymous_variant 0.21 rifampicin
rpoC 766312 c.2943T>C synonymous_variant 0.2 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.23 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.26 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.25 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.22 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.29 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.29 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.23 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.27 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.33 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.34 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.33 rifampicin
rpoC 766468 c.3099G>A synonymous_variant 0.28 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.31 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.28 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.35 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.37 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.31 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.29 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.35 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.39 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.37 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.38 rifampicin
rpoC 766627 c.3258G>T synonymous_variant 0.29 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.32 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.29 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.29 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.35 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.34 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.33 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.24 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.31 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.31 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.3 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766813 c.3444G>C synonymous_variant 0.23 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.22 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.25 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.25 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.27 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.27 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.3 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.26 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.24 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 778298 c.183G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 0.99 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.2 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.2 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.24 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.26 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.25 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.27 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.23 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.25 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.24 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.27 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.26 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.27 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.28 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.29 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.27 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.27 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.21 streptomycin
rplC 800715 c.-94A>C upstream_gene_variant 0.21 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.21 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.22 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.22 linezolid
rplC 800815 c.7C>A synonymous_variant 0.17 linezolid
rplC 801004 p.Leu66Val missense_variant 0.2 linezolid
rplC 801027 c.219C>G synonymous_variant 0.21 linezolid
rplC 801039 c.231A>G synonymous_variant 0.22 linezolid
rplC 801054 c.246G>C synonymous_variant 0.2 linezolid
rplC 801070 p.Asp88Asn missense_variant 0.19 linezolid
rplC 801073 p.Ser89Pro missense_variant 0.19 linezolid
rplC 801085 p.Thr93Ala missense_variant 0.19 linezolid Uncertain significance
rplC 801094 p.Gln96Glu missense_variant 0.19 linezolid
rplC 801099 c.291T>C synonymous_variant 0.19 linezolid
rplC 801102 c.294G>C synonymous_variant 0.19 linezolid
rplC 801114 c.306C>G synonymous_variant 0.2 linezolid
rplC 801132 c.324T>C synonymous_variant 0.22 linezolid
rplC 801136 p.Ser110Ala missense_variant 0.21 linezolid
rplC 801147 c.339T>C synonymous_variant 0.21 linezolid
rplC 801156 c.348T>C synonymous_variant 0.22 linezolid
rplC 801171 c.363A>G synonymous_variant 0.22 linezolid
rplC 801174 c.366T>C synonymous_variant 0.22 linezolid
rplC 801183 c.375C>A synonymous_variant 0.16 linezolid
rplC 801222 c.414T>C synonymous_variant 0.29 linezolid
rplC 801228 c.420T>C synonymous_variant 0.18 linezolid
rplC 801249 c.441T>G synonymous_variant 0.19 linezolid
rplC 801264 c.456C>T synonymous_variant 0.17 linezolid
rplC 801267 c.459A>C synonymous_variant 0.24 linezolid
rplC 801270 c.462T>C synonymous_variant 0.24 linezolid
rplC 801276 c.468G>C synonymous_variant 0.25 linezolid
rplC 801312 c.504G>C synonymous_variant 0.24 linezolid
rplC 801321 c.513C>T synonymous_variant 0.23 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.22 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.2 linezolid
rplC 801348 c.540T>G synonymous_variant 0.21 linezolid
rplC 801357 c.549T>C synonymous_variant 0.23 linezolid
rplC 801387 c.579G>C synonymous_variant 0.18 linezolid
rplC 801402 c.594T>C synonymous_variant 0.24 linezolid
rplC 801405 c.597T>C synonymous_variant 0.25 linezolid
rplC 801423 c.615G>C synonymous_variant 0.2 linezolid
fbiC 1303608 c.678G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303661 p.Val244Ala missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Pro missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.24 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303761 c.831T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303788 c.858T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303794 c.864A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304022 c.1092T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304040 c.1110C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304050 c.1120T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304115 c.1185A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Asp missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.22 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304757 c.1827A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304763 c.1833C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304778 p.Asp616Glu missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304799 c.1869G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304802 c.1872G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304877 c.1947T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304925 c.1995G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304970 c.2040G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305014 p.Thr695Ser missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305030 c.2100G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1305039 c.2109G>A synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305045 c.2115A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305063 c.2133G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1305069 c.2139G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305075 c.2145T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1305078 c.2148A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305092 p.Ala721Gly missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305096 c.2166T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1305099 c.2169T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475220 n.1563G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475366 n.1709G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475402 n.1746delT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
inhA 1674368 p.Ala56Glu missense_variant 0.16 isoniazid
ethionamide
inhA 1674375 c.174C>G synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674382 p.Leu61Ile missense_variant 0.19 isoniazid
ethionamide
inhA 1674428 p.Gly76Asp missense_variant 0.18 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674440 p.Glu80Ala missense_variant 0.18 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674443 p.Ala81Glu missense_variant 0.18 isoniazid
ethionamide
inhA 1674452 p.Ala84Glu missense_variant 0.18 isoniazid
ethionamide
inhA 1674465 c.264C>G synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674471 c.270G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674534 c.333G>T synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674537 c.336C>A synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.34 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674552 c.351C>G synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.32 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674567 c.366C>T synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674570 c.369G>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674573 c.372G>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674575 p.Tyr125Phe missense_variant 0.29 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.31 isoniazid
ethionamide
inhA 1674624 c.423A>T synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674627 c.426T>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674655 c.454_456delAGCinsTCG synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674690 c.489C>G synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.22 isoniazid
ethionamide
rpsA 1833589 c.48A>T synonymous_variant 0.25 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.23 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.34 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.26 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834192 c.651C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834210 c.669C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.32 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>A synonymous_variant 0.27 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834420 c.879C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834465 c.924T>A synonymous_variant 0.25 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834591 c.1050C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834633 c.1092A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834657 c.1116G>A synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834690 c.1149T>C synonymous_variant 0.27 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.23 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.23 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.23 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.22 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.2 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.19 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063187 c.1542C>T synonymous_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
katG 2155389 c.723C>G synonymous_variant 1.0 isoniazid Not assoc w R
Rv1979c 2221746 c.1416_1418dupCCG disruptive_inframe_insertion 0.96 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517989 c.-126T>G upstream_gene_variant 0.21 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.24 isoniazid
kasA 2518031 c.-84G>C upstream_gene_variant 0.23 isoniazid
kasA 2518034 c.-81T>C upstream_gene_variant 0.23 isoniazid
kasA 2518035 c.-80C>G upstream_gene_variant 0.22 isoniazid
kasA 2518040 c.-75G>T upstream_gene_variant 0.2 isoniazid
kasA 2518041 c.-74T>C upstream_gene_variant 0.23 isoniazid
kasA 2518049 c.-66G>C upstream_gene_variant 0.19 isoniazid
kasA 2518053 c.-62_-60delATTinsCTG upstream_gene_variant 0.23 isoniazid
kasA 2518059 c.-56T>A upstream_gene_variant 0.18 isoniazid
kasA 2518073 c.-42T>G upstream_gene_variant 0.25 isoniazid
kasA 2518088 c.-27T>C upstream_gene_variant 0.2 isoniazid
kasA 2518089 c.-26C>A upstream_gene_variant 0.2 isoniazid
kasA 2518100 c.-15T>G upstream_gene_variant 0.19 isoniazid
kasA 2518103 c.-12G>A upstream_gene_variant 0.19 isoniazid
kasA 2518106 c.-9C>G upstream_gene_variant 0.19 isoniazid
kasA 2518109 c.-6G>C upstream_gene_variant 0.19 isoniazid
kasA 2518110 c.-5T>A upstream_gene_variant 0.19 isoniazid
kasA 2518121 p.Gln3Lys missense_variant 0.2 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.2 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.21 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.2 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.19 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.19 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.18 isoniazid
kasA 2518334 c.220_222delCGAinsAGG synonymous_variant 0.16 isoniazid
kasA 2518348 c.234A>T synonymous_variant 0.17 isoniazid
kasA 2518385 p.Gly91Cys missense_variant 0.17 isoniazid
kasA 2518390 c.276A>T synonymous_variant 0.2 isoniazid
kasA 2518403 p.Ser97Thr missense_variant 0.19 isoniazid
kasA 2518417 c.303G>C synonymous_variant 0.19 isoniazid
kasA 2518439 p.Ala109Thr missense_variant 0.16 isoniazid
kasA 2518444 c.330T>C synonymous_variant 0.19 isoniazid
kasA 2518447 c.333T>G synonymous_variant 0.21 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.2 isoniazid
kasA 2518475 c.361A>C synonymous_variant 0.19 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.2 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.2 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.22 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.25 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.23 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.31 isoniazid
kasA 2518567 c.453G>T synonymous_variant 0.23 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.29 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.25 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.2 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.3 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.31 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.33 isoniazid
kasA 2518699 c.585C>T synonymous_variant 0.29 isoniazid
kasA 2518708 c.594C>G synonymous_variant 0.28 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.34 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.35 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.39 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.31 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.38 isoniazid
kasA 2518789 c.675G>T synonymous_variant 0.3 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.35 isoniazid
kasA 2518798 c.684G>T synonymous_variant 0.26 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.34 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.28 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.32 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.32 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.29 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.24 isoniazid
kasA 2518893 p.Lys260Thr missense_variant 0.22 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.24 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.24 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.22 isoniazid
kasA 2518915 c.801T>C synonymous_variant 0.19 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.2 isoniazid
folC 2746353 p.Ala416Ser missense_variant 0.18 para-aminosalicylic_acid
folC 2746451 p.Gly383Ala missense_variant 0.18 para-aminosalicylic_acid
folC 2746525 c.1074G>T synonymous_variant 0.16 para-aminosalicylic_acid
Rv2477c 2782525 c.1518C>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782900 c.1143C>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783014 p.Ser343Thr missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.28 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>T synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783053 c.990C>T synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783071 c.972C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783080 c.963G>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.32 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783104 c.939C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783119 c.924G>A synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>C synonymous_variant 0.34 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783164 c.879G>A synonymous_variant 0.18 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783194 c.849A>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783206 c.837G>A synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783404 c.639C>T synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783407 c.636C>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783432 p.Ser204Ala missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783500 c.541_543delTTGinsCTA synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783536 c.507G>T synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783566 c.477C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2859765 c.654G>C synonymous_variant 0.21 bedaquiline
clofazimine
pepQ 2859778 p.Val214Asp missense_variant 0.19 bedaquiline
clofazimine
pepQ 2859801 c.618G>C synonymous_variant 0.22 bedaquiline
clofazimine
pepQ 2859852 c.567A>G synonymous_variant 0.19 bedaquiline
clofazimine
pepQ 2859857 p.Val188Met missense_variant 0.19 bedaquiline
clofazimine
pepQ 2859870 c.549T>C synonymous_variant 0.19 bedaquiline
clofazimine
pepQ 2859873 c.546T>C synonymous_variant 0.19 bedaquiline
clofazimine
Rv2680 2996208 p.Ala35Asp missense_variant 0.98 capreomycin Uncertain significance
Rv2681 2996940 p.Gly68Ser missense_variant 0.16 capreomycin
Rv2681 2996945 c.207C>G synonymous_variant 0.17 capreomycin
Rv2681 2996957 c.219T>C synonymous_variant 0.18 capreomycin
Rv2681 2996974 p.Glu79Gly missense_variant 0.18 capreomycin
Rv2681 2997013 p.Gly92Ala missense_variant 0.19 capreomycin
Rv2681 2997021 c.283T>C synonymous_variant 0.19 capreomycin
Rv2681 2997026 c.288C>G synonymous_variant 0.19 capreomycin
Rv2681 2997033 p.Ala99Pro missense_variant 0.19 capreomycin
Rv2752c 3065430 c.762A>T synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065463 c.729T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065487 c.705T>G synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065490 c.702A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065493 c.699G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065496 c.696G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065499 c.693A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065508 c.684T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065517 c.675C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065532 c.660A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065553 c.639A>G synonymous_variant 0.22 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065577 c.615C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065580 c.612G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065595 p.Leu199Phe missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067474 p.Pro158Ala missense_variant 0.97 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.21 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.23 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074147 p.Ile109Val missense_variant 0.19 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074165 p.Ala103Thr missense_variant 0.18 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.18 para-aminosalicylic_acid
Rv3083 3448567 p.His22Asp missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3612571 c.546C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
lpqB 3624739 p.Ala58Ser missense_variant 0.94 rifampicin Uncertain significance
bedaquiline Uncertain significance
lpqB 3625528 c.-618G>T upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625537 c.-627T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625592 p.Ser341Asn missense_variant 0.24 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625615 p.Arg333Ala missense_variant 0.21 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.29 rifampicin
bedaquiline
lpqB 3625675 c.-765G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.2 rifampicin Uncertain significance
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626852 c.-239G>A upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626857 c.-244T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626882 c.-269G>A upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626891 c.-278G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3626939 p.Glu137Asp missense_variant 0.23 rifampicin
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626999 c.-386G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627011 c.-398T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627071 c.-458G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627110 c.-497G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627119 c.-506T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627137 c.-526_-524delTTGinsCTC upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627170 c.-557C>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627187 c.163T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627188 c.-577_-575delTTAinsCTG upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3627208 c.142C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627227 c.-614T>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627254 c.-641C>A upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627301 c.-688T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627325 c.-712T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
fbiA 3640930 p.Glu130Lys missense_variant 0.18 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
fbiB 3640965 c.-570C>G upstream_gene_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3640966 c.-569T>C upstream_gene_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3640989 c.-546T>C upstream_gene_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3640995 c.-540A>G upstream_gene_variant 0.21 pretomanid
delamanid
clofazimine
fbiB 3640998 c.-537C>G upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3641001 c.-534T>C upstream_gene_variant 0.21 pretomanid
delamanid
clofazimine
fbiB 3641004 c.-531A>G upstream_gene_variant 0.21 pretomanid
delamanid
clofazimine
fbiB 3641016 c.-519C>T upstream_gene_variant 0.23 pretomanid
delamanid
clofazimine
fbiA 3641021 p.Val160Ala missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiA 3641028 p.Glu162Asp missense_variant 0.2 pretomanid
delamanid
clofazimine
rpoA 3877613 p.Ile299Val missense_variant 0.19 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.2 rifampicin
rpoA 3877677 p.Ala277Thr missense_variant 0.19 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.21 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.24 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.21 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.27 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.31 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.31 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.24 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.35 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.33 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.32 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.28 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.34 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.33 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.32 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.32 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.36 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.32 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.32 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.31 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.3 rifampicin
rpoA 3878143 p.Gly122Ala missense_variant 0.27 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.28 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.37 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.27 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878256 c.252G>C synonymous_variant 0.27 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.29 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.34 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.31 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>C synonymous_variant 0.31 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.29 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.36 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878406 c.102G>C synonymous_variant 0.27 rifampicin
rpoA 3878415 c.93C>G synonymous_variant 0.26 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.25 rifampicin
rpoA 3878432 c.76C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878442 c.66G>C synonymous_variant 0.35 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.26 rifampicin
rpoA 3878458 p.Asn17Thr missense_variant 0.23 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.34 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.24 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.26 rifampicin
rpoA 3878695 c.-188C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.3 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.25 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.29 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878749 c.-242G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.29 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.3 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.32 rifampicin
rpoA 3878830 c.-323G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.28 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.25 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878889 c.-382A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878890 c.-383C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878893 c.-388_-386delCACinsAAG upstream_gene_variant 0.2 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878917 c.-410G>T upstream_gene_variant 0.24 rifampicin
rpoA 3878926 c.-419C>G upstream_gene_variant 0.25 rifampicin
rpoA 3878935 c.-428C>T upstream_gene_variant 0.29 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGTT upstream_gene_variant 0.23 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.28 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.24 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.3 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.31 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879097 c.-590C>G upstream_gene_variant 0.21 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.22 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.18 rifampicin
clpC1 4038398 c.2307G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.19 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.21 pyrazinamide
clpC1 4038461 c.2244G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038485 c.2220C>A synonymous_variant 0.17 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.19 pyrazinamide
clpC1 4038506 c.2199G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.26 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.25 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038599 c.2106G>A synonymous_variant 0.2 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.27 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.23 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.24 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038683 c.2022T>G synonymous_variant 0.18 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.18 pyrazinamide
clpC1 4038896 c.1809C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.26 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.26 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.25 pyrazinamide
clpC1 4039331 c.1374C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039337 c.1368A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039574 c.1131G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039616 c.1089G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.19 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039910 c.795C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039942 c.763C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.31 pyrazinamide
clpC1 4039951 c.754C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.28 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.23 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040096 c.609G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.22 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.23 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.24 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.2 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040330 c.375C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.19 pyrazinamide
clpC1 4040528 c.177G>T synonymous_variant 0.16 pyrazinamide
glpK 4138418 c.1338T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138451 c.1305T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138496 c.1260G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138640 c.1116C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.17 ethambutol Not assoc w R
embC 4240726 c.864G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4240831 c.969T>G synonymous_variant 0.19 ethambutol
embC 4240852 c.990G>A synonymous_variant 0.17 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.22 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.21 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.19 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.21 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.19 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.19 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.2 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.22 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.23 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.23 ethambutol
embC 4240979 p.Thr373Pro missense_variant 0.22 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.23 ethambutol
embC 4240990 c.1128A>C synonymous_variant 0.23 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.27 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.24 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.23 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.23 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.22 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.2 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.19 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.19 ethambutol
embC 4242550 c.2688C>G synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244823 p.Val531Met missense_variant 0.17 ethambutol
embA 4244829 p.Phe533Val missense_variant 0.18 ethambutol
embA 4244846 c.1614C>G synonymous_variant 0.24 ethambutol
embA 4244850 p.Arg540Gly missense_variant 0.24 ethambutol
embA 4244856 p.Ala542Pro missense_variant 0.23 ethambutol
embA 4244873 c.1641C>G synonymous_variant 0.23 ethambutol
embA 4244879 c.1647C>G synonymous_variant 0.22 ethambutol
embA 4244885 c.1653A>G synonymous_variant 0.24 ethambutol
embA 4244886 c.1654C>T synonymous_variant 0.22 ethambutol
embA 4244897 c.1665T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embA 4244900 c.1668G>C synonymous_variant 0.28 ethambutol
embA 4244921 c.1689C>G synonymous_variant 0.3 ethambutol
embA 4244930 c.1698G>C synonymous_variant 0.24 ethambutol
embA 4244933 c.1701A>G synonymous_variant 0.28 ethambutol
embA 4244936 c.1704C>G synonymous_variant 0.24 ethambutol
embA 4244960 c.1728A>G synonymous_variant 0.26 ethambutol
embA 4244966 c.1734C>G synonymous_variant 0.21 ethambutol
embA 4244969 c.1737G>C synonymous_variant 0.2 ethambutol
embA 4244970 c.1738C>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embA 4244976 p.Gly582Ser missense_variant 0.2 ethambutol
embA 4244980 p.Val583Ala missense_variant 0.25 ethambutol
embA 4244982 c.1750T>C synonymous_variant 0.25 ethambutol
embA 4244993 c.1761C>G synonymous_variant 0.25 ethambutol
embA 4245003 p.Thr591Ala missense_variant 0.32 ethambutol Uncertain significance
embA 4245008 c.1776T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embA 4245014 c.1782C>G synonymous_variant 0.32 ethambutol
embA 4245020 c.1788T>C synonymous_variant 0.29 ethambutol
embA 4245023 c.1791A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embA 4245026 c.1794T>C synonymous_variant 0.28 ethambutol
embA 4245029 c.1797T>C synonymous_variant 0.29 ethambutol
embA 4245032 c.1800A>C synonymous_variant 0.29 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.28 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embA 4245089 c.1857G>C synonymous_variant 0.23 ethambutol
embA 4245093 p.Ile621Val missense_variant 0.22 ethambutol Uncertain significance
embA 4245101 c.1869G>C synonymous_variant 0.22 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.19 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol
embA 4245745 p.Pro838Leu missense_variant 0.85 ethambutol Uncertain significance
embB 4248064 c.1551G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.21 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.23 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.25 ethambutol
embB 4248106 c.1593C>G synonymous_variant 0.19 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.21 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.21 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.24 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.27 ethambutol Uncertain significance
embB 4248217 c.1704C>G synonymous_variant 0.21 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.22 ethambutol
embB 4248232 c.1719G>T synonymous_variant 0.23 ethambutol
embB 4248235 c.1722G>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248256 c.1743C>G synonymous_variant 0.24 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.22 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.27 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.19 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.19 ethambutol
embB 4249462 c.2949G>T synonymous_variant 0.16 ethambutol
embB 4249465 c.2952G>A synonymous_variant 0.16 ethambutol
embB 4249505 p.Gln998Lys missense_variant 0.17 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.19 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.2 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.2 ethambutol
embB 4249568 p.Ser1019Asn missense_variant 0.19 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.19 ethambutol
embB 4249581 p.Leu1023Gln missense_variant 0.2 ethambutol
embB 4249607 p.Thr1032Val missense_variant 0.2 ethambutol
embB 4249624 c.3111C>G synonymous_variant 0.19 ethambutol
embB 4249627 c.3114G>C synonymous_variant 0.19 ethambutol
aftB 4267272 p.Lys522Arg missense_variant 0.96 ethambutol Not assoc w R
ethA 4326739 c.735C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
ethR 4328004 c.456G>A synonymous_variant 0.99 ethionamide Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin