TB-Profiler result

Run: ERR9786617
Summary

Run ID: ERR9786617

Sample name:

Date: 2024-10-04T13:15:27.084761

Number of reads: 1214096

Percentage reads mapped: 79.14

Median coverage: 54.0

Strain: lineage4.1.1.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.95
lineage4.1.1.1 Euro-American (X-type) RD183 0.85
lineage4 Euro-American None 0.99
lineage4.1.1 Euro-American (X-type) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Leu359Ile Uncertain significance Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247448 p.His312Arg missense_variant 0.26 ethambutol Mutation from literature
embB 4247588 p.Leu359Ile missense_variant 0.22 ethambutol Uncertain significance Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.22 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6289 c.1050C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6418 c.-884C>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6440 p.Thr401Ala missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6484 c.-818A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6490 c.-812T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6565 c.-737G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6598 c.-704C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6898 c.-404G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7664 c.363T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCGC synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCTC synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7739 c.438C>T synonymous_variant 0.2 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7763 c.462T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8129 c.828T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTTG synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8357 c.1056G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8400 p.Asp367Asn missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8579 p.Asp426Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8672 c.1371A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8708 c.1407G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9179 c.1878C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9344 c.2043C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490887 c.105G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490890 c.108C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490896 c.114C>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490929 c.147C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490932 c.150T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490935 c.153C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490974 c.192T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490984 p.Leu68Met missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490987 p.Leu69Met missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491043 c.261T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491049 c.267T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
ccsA 619507 c.-384A>G upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619528 c.-363C>G upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619531 c.-360T>C upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619543 c.-348C>G upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619552 c.-339A>G upstream_gene_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 619555 c.-336C>G upstream_gene_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 619561 c.-330G>C upstream_gene_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 619570 c.-321G>C upstream_gene_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 619574 c.-317G>A upstream_gene_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 619579 c.-312G>C upstream_gene_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 619584 c.-307A>T upstream_gene_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 619609 c.-282G>C upstream_gene_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 619634 c.-257T>A upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619654 c.-237A>G upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619672 c.-219A>T upstream_gene_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620298 c.408G>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620310 c.420C>T synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.21 kanamycin
capreomycin
amikacin
Rv0565c 656391 c.1080C>G synonymous_variant 0.19 ethionamide
Rv0565c 656402 p.Ala357Thr missense_variant 0.2 ethionamide
Rv0565c 656412 c.1059T>G synonymous_variant 0.22 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.24 ethionamide
Rv0565c 656448 p.Ile341Val missense_variant 0.23 ethionamide
Rv0565c 656454 c.1017G>C synonymous_variant 0.22 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.22 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.19 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.21 ethionamide
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.16 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.28 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.31 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.3 isoniazid
rpoB 760130 p.Asp108Glu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.19 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.26 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.25 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.25 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.25 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.24 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.29 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.27 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.28 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.33 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.3 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.39 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.33 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.36 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.45 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.3 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.22 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.21 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.19 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.31 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.3 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.39 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.37 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.37 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.36 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.37 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.34 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.31 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.28 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.26 rifampicin
rpoB 761373 p.Val523His missense_variant 0.21 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.25 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.23 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.23 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.24 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.3 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.25 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.33 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.28 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.24 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.23 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.18 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.2 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.2 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.22 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.26 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.3 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.33 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.31 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.34 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.32 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.31 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.32 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.34 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.36 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.35 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.37 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.37 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.36 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.32 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.32 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.34 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.34 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.34 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.36 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.36 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.34 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.33 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.33 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.37 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.36 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.36 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.37 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.35 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.35 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.29 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.31 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.35 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.37 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.34 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.34 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.4 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.32 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.31 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.33 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.3 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.33 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.33 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.33 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.28 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.28 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.28 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.32 rifampicin
rpoB 762729 p.Gln975Lys missense_variant 0.18 rifampicin
rpoB 762736 p.Ala977Glu missense_variant 0.18 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.44 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.46 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.35 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.29 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.2 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.2 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.26 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.35 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.29 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.31 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.29 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.29 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.34 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.37 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.37 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.35 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.31 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.31 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.33 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.33 rifampicin
rpoC 763877 c.508_510delCTAinsTTG synonymous_variant 0.32 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.32 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.32 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.32 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.33 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.3 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763991 p.Ile208Leu missense_variant 0.24 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.23 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.25 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.27 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.27 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.26 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.26 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.32 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.32 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.34 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.39 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.35 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.33 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.32 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.35 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.32 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.32 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.32 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.31 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.31 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.27 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.26 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.28 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.28 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.29 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.33 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.31 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.3 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.29 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.26 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.27 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.27 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.34 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.32 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.3 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.3 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.23 rifampicin
rpoC 765047 c.1678T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.22 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.18 rifampicin
rpoC 765082 c.1713G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.18 rifampicin
rpoC 765150 p.Gly594Glu missense_variant 0.89 rifampicin Not assoc w R
rpoC 765346 c.1977C>G synonymous_variant 0.19 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.25 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.29 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.28 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.37 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.37 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.41 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.4 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.48 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.47 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.47 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.47 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.47 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.47 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.48 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.48 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.47 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.47 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.46 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.4 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.41 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.39 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.42 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.4 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.36 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.36 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.34 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.35 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.34 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.33 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.32 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.29 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.25 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.24 rifampicin
rpoC 766174 p.Asn935Lys missense_variant 0.22 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.22 rifampicin
rpoC 766185 p.Glu939Ala missense_variant 0.21 rifampicin
rpoC 766189 c.2820T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766192 c.2823T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766193 p.Gln942Glu missense_variant 0.21 rifampicin
rpoC 766204 c.2835C>T synonymous_variant 0.2 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.19 rifampicin
rpoC 766216 c.2847T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766222 c.2853T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766231 c.2862T>G synonymous_variant 0.2 rifampicin
rpoC 766234 c.2865T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766237 c.2868T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766240 c.2871T>C synonymous_variant 0.21 rifampicin
rpoC 766243 c.2874C>G synonymous_variant 0.21 rifampicin
rpoC 766258 c.2889T>C synonymous_variant 0.26 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.25 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.24 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.24 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.27 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.28 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.28 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.28 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.29 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.29 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.3 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.31 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.28 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.29 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.33 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.39 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.41 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.41 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.39 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.42 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.39 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.39 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.37 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.34 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.33 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.35 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.34 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.33 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.32 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.33 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.35 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.33 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.34 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.29 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.28 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.28 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.33 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.38 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.33 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.43 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.5 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.6 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.6 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.43 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.43 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.46 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.4 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.24 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.19 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 0.99 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.23 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.23 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.26 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.28 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.27 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.3 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.3 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.3 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.3 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.28 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.29 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.28 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.27 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.28 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.31 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.32 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.28 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.29 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.29 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.27 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.26 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.28 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.27 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.31 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.3 streptomycin Uncertain significance
rplC 800219 c.-590T>C upstream_gene_variant 1.0 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.19 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.21 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.26 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.28 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.23 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.23 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.24 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.25 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.26 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.26 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.26 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.25 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.22 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.17 linezolid
rplC 800814 c.6A>G synonymous_variant 0.19 linezolid
rplC 800817 c.9A>T synonymous_variant 0.19 linezolid
rplC 800844 c.36T>C synonymous_variant 0.18 linezolid
rplC 800916 c.108A>G synonymous_variant 0.18 linezolid
rplC 800967 c.159C>G synonymous_variant 0.17 linezolid
rplC 801127 p.Ala107Thr missense_variant 0.19 linezolid
rplC 801132 c.324T>C synonymous_variant 0.19 linezolid
rplC 801147 c.339T>C synonymous_variant 0.18 linezolid
rplC 801150 c.342G>C synonymous_variant 0.18 linezolid
rplC 801153 c.345G>C synonymous_variant 0.18 linezolid
rplC 801156 c.348T>A synonymous_variant 0.18 linezolid
rplC 801168 c.360C>G synonymous_variant 0.19 linezolid
rplC 801171 c.363A>G synonymous_variant 0.19 linezolid
rplC 801174 c.366T>C synonymous_variant 0.19 linezolid
rplC 801195 c.387G>C synonymous_variant 0.23 linezolid
rplC 801207 c.399C>T synonymous_variant 0.24 linezolid
rplC 801246 c.438C>T synonymous_variant 0.17 linezolid
rplC 801249 c.441T>C synonymous_variant 0.18 linezolid
rplC 801255 c.447C>T synonymous_variant 0.18 linezolid
rplC 801264 c.456C>T synonymous_variant 0.16 linezolid
rplC 801321 c.513C>T synonymous_variant 0.18 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.19 linezolid
rplC 801402 c.594T>C synonymous_variant 0.24 linezolid
rplC 801405 c.597T>C synonymous_variant 0.25 linezolid
rplC 801423 c.615G>C synonymous_variant 0.24 linezolid
rplC 801426 c.618C>G synonymous_variant 0.24 linezolid
rplC 801427 p.Met207Val missense_variant 0.24 linezolid
rplC 801438 c.630T>C synonymous_variant 0.32 linezolid
rplC 801442 p.Ile212Val missense_variant 0.32 linezolid
Rv1129c 1254635 c.-101C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
fbiC 1303641 c.711C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303671 c.741C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1303674 c.744C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303681 c.751T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.27 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303827 c.897A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303866 p.Glu312Asp missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303971 c.1041T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303977 c.1047C>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303998 c.1068T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304010 p.Leu360Phe missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304022 c.1092T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304049 c.1119T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304058 c.1128G>A synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304059 c.1129C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304064 c.1134G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304067 c.1137G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304085 c.1155C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304091 p.Asp387Glu missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304092 p.Met388Leu missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304097 c.1167G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304184 c.1254G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304187 c.1257T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304661 c.1731C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.23 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.3 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
sigE 1364793 c.381C>T synonymous_variant 0.16 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.17 pyrazinamide
sigE 1364814 c.402C>A synonymous_variant 0.18 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.19 pyrazinamide
sigE 1364839 c.427_429delTTGinsCTC synonymous_variant 0.23 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.24 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.28 pyrazinamide
sigE 1364862 c.450C>A synonymous_variant 0.31 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.31 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.31 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.25 pyrazinamide
sigE 1364898 c.486C>T synonymous_variant 0.24 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.22 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.24 pyrazinamide
sigE 1364943 c.531C>T synonymous_variant 0.2 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.2 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673710 c.-492C>A upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673716 c.-486_-485delGCinsAA upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673733 c.-469G>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673748 c.-454A>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673749 c.-453_-452delAAinsCG upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673758 c.-444A>G upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673778 c.-424C>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673784 c.-418G>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673797 c.-405_-403delGCTinsACC upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673802 c.-400A>G upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673805 c.-397G>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673808 c.-394A>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673809 c.-393T>G upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673823 c.-378_-375delCGCA upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673829 c.-373C>A upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673832 c.-370_-369insGCGG upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673841 c.-361A>C upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673844 c.-358G>C upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673847 c.-355A>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673849 c.-353T>A upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673853 c.-349A>C upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673856 c.-346T>C upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673890 c.-312G>T upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673901 c.-301A>G upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673916 c.-286A>C upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673917 c.-285G>C upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673941 c.-261G>T upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1674672 c.471C>G synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.21 isoniazid
ethionamide
rpsA 1833661 c.120A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.21 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.21 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.41 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.31 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.26 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.24 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.2 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.26 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.27 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.29 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.29 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.2 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.2 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.2 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.21 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064942 c.-214G>A upstream_gene_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.3 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.3 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.3 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.3 kanamycin
capreomycin
streptomycin
amikacin
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.26 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.3 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.3 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.22 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.22 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.24 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.19 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.21 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.24 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.24 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.24 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.26 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.35 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.26 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.28 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.28 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.26 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.24 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.21 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.21 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.22 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.24 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.24 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.21 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.22 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.23 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.22 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.26 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.24 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.23 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.21 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.23 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.26 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.26 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.26 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.2 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.21 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.24 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.26 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.26 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.27 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.26 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.25 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.26 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.28 isoniazid
kasA 2518993 c.879C>G synonymous_variant 0.26 isoniazid
kasA 2518999 c.885G>C synonymous_variant 0.26 isoniazid
kasA 2519008 c.894C>G synonymous_variant 0.28 isoniazid
kasA 2519017 c.903G>C synonymous_variant 0.29 isoniazid
ahpC 2726210 c.18T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv2477c 2782741 c.1302G>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.28 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>T synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.31 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.33 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.35 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.27 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783425 p.Pro206Ala missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.27 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783431 c.610_612delAGCinsTCG synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783437 c.606G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783497 c.544_546delTTGinsCTC synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.33 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783521 c.522G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.33 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.35 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2752c 3065040 c.1152C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065052 c.1140G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065055 c.1137T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065073 c.1119C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065082 c.1110G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065088 c.1104A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065109 p.Arg361Ser missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065115 c.1077C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065131 p.Ala354Glu missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065142 c.1050A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065151 c.1041G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065183 p.Ser337Ala missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065186 c.1006T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065190 p.Ile334Val missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065196 c.996T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065202 c.990T>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065205 c.987T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065210 c.982T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065223 c.969T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065262 c.930G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065268 c.924A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067316 c.630A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067388 c.558C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.3 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.26 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.24 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.26 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.23 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.24 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.25 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.2 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.2 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.18 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067691 p.Ile85Met missense_variant 0.18 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067736 p.Phe70Leu missense_variant 0.21 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067754 c.192C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.16 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074163 p.Ala103Thr missense_variant 0.2 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.24 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074244 c.228A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074254 p.His73Arg missense_variant 0.19 para-aminosalicylic_acid
thyA 3074268 c.204T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074286 c.186T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074297 c.175C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074301 c.171C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074304 p.Ala56Val missense_variant 0.2 para-aminosalicylic_acid
thyA 3074307 c.165A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074313 c.159A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074319 c.153T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074322 c.150C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074325 c.147A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074328 c.144G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074346 c.126C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074349 c.123T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074360 c.112T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074361 c.111T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074364 c.108T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074372 p.Met34Leu missense_variant 0.23 para-aminosalicylic_acid
thyA 3074377 p.Gln32Arg missense_variant 0.21 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625149 p.Val489Ile missense_variant 0.22 rifampicin
bedaquiline
lpqB 3625161 c.-251T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625162 c.1452T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625186 c.-276T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3625189 c.1425A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625195 c.-285A>G upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625201 c.-291T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625206 p.Ser470Ala missense_variant 0.23 rifampicin
bedaquiline
mtrB 3625222 c.1392T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625225 c.-315G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625240 c.-330T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625267 c.1347T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625270 c.-360G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625279 c.-369C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625291 c.-381A>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625301 p.Ala438Gly missense_variant 0.21 rifampicin
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.17 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.34 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.33 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.33 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.34 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.36 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.32 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.24 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625903 c.-993G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626330 p.Glu95Gly missense_variant 0.9 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3626858 c.-245A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3627299 c.51G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.17 rifampicin
bedaquiline
fbiA 3641447 p.Thr302Met missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
rpoA 3877553 p.Glu319Lys missense_variant 1.0 rifampicin Not assoc w R
rpoA 3877571 p.Pro313Ala missense_variant 0.19 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.26 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.26 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.29 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.29 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.29 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.31 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877748 c.760C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.29 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.26 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.29 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.27 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.27 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.26 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.25 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.28 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.28 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.28 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.34 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.31 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.31 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.31 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.3 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878055 c.453A>G synonymous_variant 0.28 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.28 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.28 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.28 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.3 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.3 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.29 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.28 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.27 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.26 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.28 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.28 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.29 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.31 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.31 rifampicin
rpoA 3878187 c.321C>A synonymous_variant 0.32 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.33 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.33 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.28 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.31 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.31 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.32 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.42 rifampicin
rpoA 3878352 c.156C>G synonymous_variant 0.42 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.42 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.42 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.41 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.38 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.4 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.4 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.38 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.44 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.42 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.42 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.4 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.35 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.35 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.32 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.35 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.35 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.32 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.33 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.32 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.4 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878881 c.-374C>T upstream_gene_variant 0.34 rifampicin
rpoA 3878890 c.-383C>G upstream_gene_variant 0.36 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878932 c.-425G>A upstream_gene_variant 0.36 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.37 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.35 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.35 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.27 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.28 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.24 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.18 rifampicin
clpC1 4038320 c.2385G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.27 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.27 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.27 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.26 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.26 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.29 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.27 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.27 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.28 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.28 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.33 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.29 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.25 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.25 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.34 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.36 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.35 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.35 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.28 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.28 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.28 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.28 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.34 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.33 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.34 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.33 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.28 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.28 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.27 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.19 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.19 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.2 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.3 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.24 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040501 c.204C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.18 pyrazinamide
panD 4044781 c.-500C>T upstream_gene_variant 0.17 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.24 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.24 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.25 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.25 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.23 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.22 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.24 pyrazinamide
panD 4044860 c.-579C>G upstream_gene_variant 0.24 pyrazinamide
panD 4044872 c.-591C>G upstream_gene_variant 0.18 pyrazinamide
glpK 4138580 c.1176C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138598 c.1158G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138601 c.1155G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138604 c.1150_1152delTTGinsCTA synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138610 c.1146C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138622 c.1134C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138625 c.1131G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138628 c.1128T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138654 c.1102C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138681 p.Met359Val missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138721 c.1035G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138730 c.1026C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138763 c.993G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139207 c.549T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139231 c.525A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139243 c.513A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139252 p.Asn168His missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139264 p.Ala164Asp missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139270 c.486C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139273 c.483A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139276 c.480T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139290 c.466C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139297 c.459G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139408 c.348T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139417 c.339A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139420 c.336T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139432 c.324C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139537 c.219G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139541 p.Ile72Thr missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139545 c.211T>C synonymous_variant 0.2 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139552 p.Ala68Ser missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139561 c.195G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139601 p.Arg52Gln missense_variant 0.36 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
embC 4240630 c.768C>A synonymous_variant 0.2 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.2 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.19 ethambutol
embC 4240669 c.807G>C synonymous_variant 0.18 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.18 ethambutol Not assoc w R
embC 4240685 p.Thr275Ala missense_variant 0.17 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4240897 c.1035C>G synonymous_variant 1.0 ethambutol Not assoc w R
embC 4240945 c.1083T>G synonymous_variant 0.18 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.18 ethambutol
embC 4240960 c.1098G>C synonymous_variant 0.17 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.18 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.26 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.24 ethambutol
embC 4241530 c.1668C>A synonymous_variant 0.17 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.22 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.23 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.24 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.23 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.23 ethambutol
embC 4241648 c.1786_1788delTTGinsCTC synonymous_variant 0.23 ethambutol
embC 4241657 p.Ser599Pro missense_variant 0.25 ethambutol
embC 4241665 c.1803G>C synonymous_variant 0.26 ethambutol
embC 4241671 c.1809T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.91 ethambutol Not assoc w R
embA 4244632 p.Thr467Ile missense_variant 0.17 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.16 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.18 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.18 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.18 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.24 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.28 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.25 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.23 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.23 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.22 ethambutol
embA 4245248 c.2016G>C synonymous_variant 0.24 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.24 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embA 4245282 p.Ile684Val missense_variant 0.23 ethambutol
embA 4245285 c.2053T>C synonymous_variant 0.22 ethambutol
embA 4245290 c.2058C>G synonymous_variant 0.23 ethambutol
embA 4245293 c.2061T>G synonymous_variant 0.23 ethambutol
embA 4245296 c.2064G>C synonymous_variant 0.22 ethambutol
embA 4245299 c.2067A>G synonymous_variant 0.23 ethambutol
embB 4246184 c.-330A>C upstream_gene_variant 0.19 ethambutol
embB 4246196 c.-318C>G upstream_gene_variant 0.19 ethambutol
embB 4246205 c.-309A>G upstream_gene_variant 0.2 ethambutol
embB 4246217 c.-297G>A upstream_gene_variant 0.19 ethambutol
embA 4246220 c.2988T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4246223 c.-291C>T upstream_gene_variant 0.2 ethambutol
embA 4246227 p.Ile999Val missense_variant 0.2 ethambutol
embA 4246235 c.3003G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embA 4246243 p.Gln1004Arg missense_variant 0.18 ethambutol Uncertain significance
embB 4246250 c.-264G>C upstream_gene_variant 0.18 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.21 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.18 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.18 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.21 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.21 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.21 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.23 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.23 ethambutol
embB 4247413 c.900C>T synonymous_variant 0.22 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.24 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.24 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.24 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.25 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.27 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.39 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.34 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.33 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.3 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.31 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.28 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.27 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.27 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.22 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.21 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.2 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247683 c.1170C>G synonymous_variant 0.17 ethambutol
embB 4247692 c.1179C>G synonymous_variant 0.19 ethambutol
embB 4247716 c.1203C>T synonymous_variant 0.2 ethambutol
embB 4247722 c.1209G>T synonymous_variant 0.2 ethambutol
embB 4247725 c.1212G>C synonymous_variant 0.2 ethambutol
embB 4247729 p.Gly406Pro missense_variant 0.2 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.24 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.29 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.25 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.24 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.3 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.31 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.33 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.35 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.34 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.41 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.43 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.43 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.42 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.41 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.41 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.38 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.41 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.38 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.35 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.34 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.31 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.19 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.2 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.2 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.23 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.23 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.22 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.22 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.26 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.27 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.25 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.25 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.25 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.24 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.24 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.24 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.25 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.25 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.25 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.25 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.27 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.29 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.23 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.21 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.19 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.18 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.15 ethambutol
embB 4249408 c.2895G>A synonymous_variant 0.92 ethambutol Not assoc w R
aftB 4269042 c.-206G>C upstream_gene_variant 0.19 ethambutol
ubiA 4269075 p.Ile253Val missense_variant 0.2 ethambutol
aftB 4269081 c.-245G>C upstream_gene_variant 0.19 ethambutol
aftB 4269084 c.-248G>C upstream_gene_variant 0.18 ethambutol
ubiA 4269164 p.Leu224Met missense_variant 0.18 ethambutol
aftB 4269165 c.-329G>C upstream_gene_variant 0.18 ethambutol
aftB 4269179 c.-343C>A upstream_gene_variant 0.24 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.22 ethambutol
aftB 4269186 c.-350C>G upstream_gene_variant 0.22 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.19 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.18 ethambutol
aftB 4269234 c.-398A>G upstream_gene_variant 0.19 ethambutol
whiB6 4338498 p.Glu8Asp missense_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin