TB-Profiler result

Run: SRR11349145
Summary

Run ID: SRR11349145

Sample name:

Date: 2024-10-04T05:43:43.771019

Number of reads: 5790497

Percentage reads mapped: 73.14

Median coverage: 180.0

Strain: lineage4.4.1.1.1

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.4.1.1.1 Euro-American None 1.0
lineage4.4.1 Euro-American (S-type) None 1.0
lineage4 Euro-American None 1.0
lineage4.4.1.1 Euro-American None 1.0
lineage4.4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser431Thr Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Ile Assoc w R
pyrazinamide pncA p.Tyr34Asp Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ofloxacin
levofloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrB 6738 p.Thr500Asn missense_variant 0.14 levofloxacin Uncertain significance Mutation from literature
moxifloxacin Uncertain significance Mutation from literature
rpoB 761098 p.Ser431Thr missense_variant 0.12 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761155 p.Ser450Leu missense_variant 0.88 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.97 streptomycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2289142 p.Tyr34Asp missense_variant 1.0 pyrazinamide Assoc w R
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6703 c.-599G>C upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrB 6724 c.1485G>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6727 c.-575G>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 p.Ala504Ser missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6764 p.Leu509Phe missense_variant 0.14 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.14 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6811 c.1572C>T synonymous_variant 0.17 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7051 p.Glu604Asp missense_variant 0.13 levofloxacin
moxifloxacin
gyrB 7058 p.Ile607Val missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7066 c.-236G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 7088 p.Asp617Asn missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7120 c.-182T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7136 c.-166_-164delTTGinsCTT upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8849 c.1548C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rpoB 760160 p.Asp118Glu missense_variant 0.12 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.14 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.13 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760185 c.379C>T synonymous_variant 0.13 rifampicin
rpoB 760199 c.393C>G synonymous_variant 0.13 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.13 rifampicin
rpoB 760527 p.Gln241Glu missense_variant 0.12 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>T synonymous_variant 0.14 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.15 rifampicin Uncertain significance
rpoB 760571 c.765G>C synonymous_variant 0.16 rifampicin
rpoB 760585 p.Asn260Ser missense_variant 0.14 rifampicin
rpoB 760611 c.805_807delTTGinsCTC synonymous_variant 0.12 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.13 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761075 c.1269G>A synonymous_variant 0.14 rifampicin
rpoB 761084 c.1278C>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.12 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.14 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.15 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.16 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.17 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 762002 c.2196C>G synonymous_variant 0.13 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.14 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762026 c.2220G>T synonymous_variant 0.18 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.21 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.2 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.2 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.2 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.18 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.15 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.14 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.14 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.19 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763049 c.-321G>A upstream_gene_variant 0.2 rifampicin
rpoC 763052 c.-318G>C upstream_gene_variant 0.21 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.17 rifampicin
rpoC 763079 c.-291C>G upstream_gene_variant 0.17 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763124 c.-246C>T upstream_gene_variant 0.14 rifampicin
rpoC 763504 c.135C>G synonymous_variant 0.13 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.13 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.12 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.12 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.12 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.13 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.18 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.27 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.25 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.25 rifampicin
rpoC 763714 c.345G>T synonymous_variant 0.24 rifampicin
rpoC 763726 c.357C>T synonymous_variant 0.22 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.2 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.16 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.16 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.12 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.19 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.16 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.19 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.29 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.28 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.27 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.27 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.27 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764737 c.1368G>C synonymous_variant 0.22 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.22 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.2 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.18 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.17 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.17 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764858 p.Leu497Met missense_variant 0.18 rifampicin
rpoC 764872 c.1503A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.12 rifampicin
rpoC 764912 p.Met515Leu missense_variant 0.12 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.13 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.13 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.13 rifampicin Uncertain significance
rpoC 765910 c.2541G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.13 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.12 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.13 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.13 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766487 p.Pro1040Ser missense_variant 0.96 rifampicin Uncertain significance
rpoC 767023 c.3654C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767041 c.3672G>C synonymous_variant 0.15 rifampicin
rpoC 767044 c.3675G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.17 rifampicin
rpoC 767071 c.3702C>G synonymous_variant 0.16 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.16 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767093 c.3724_3725delAGinsTC synonymous_variant 0.13 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.12 rifampicin
rpoC 767110 c.3741T>C synonymous_variant 0.12 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781859 c.300T>C synonymous_variant 0.12 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.12 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.13 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.14 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.14 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.13 streptomycin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471914 n.69A>G non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471943 n.98T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471978 n.133C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471981 n.136C>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>C non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472043 n.198T>G non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199_200delGTinsTG non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472057 n.212C>A non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472067 n.222G>A non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472068 n.223T>C non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472070 n.225G>A non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.58 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>A non_coding_transcript_exon_variant 0.35 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.36 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.34 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472328 n.483G>T non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472427 n.582T>C non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472449 n.604C>T non_coding_transcript_exon_variant 0.39 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.39 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.39 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>A non_coding_transcript_exon_variant 0.4 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472467 n.622G>T non_coding_transcript_exon_variant 0.4 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472484 n.639A>G non_coding_transcript_exon_variant 0.49 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472497 n.652G>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.14 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472682 n.837_838delTTinsAC non_coding_transcript_exon_variant 0.61 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.46 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472844 n.999C>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472845 n.1000G>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472855 n.1011_1012insGT non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472861 n.1016_1018delGTTinsC non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.48 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631_646delCCTTTTCCTCTCCGGAinsTCCACTTCGGT non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474305 n.648G>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474350 n.693G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474355 n.698A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474664 n.1007G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474666 n.1009T>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474670 n.1013C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474679 n.1022G>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474684 n.1027T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474687 n.1030C>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474711 n.1054G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474716 n.1059_1060delAAinsGAG non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475422 n.1765A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475427 n.1772delG non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475433 n.1776A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475735 n.2078T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475760 n.2103_2112delCCGCAAGGGTinsGTTTTCGGACGC non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475791 n.2134A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476030 n.2373_2378delACCTCGinsGCTGAC non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.78 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.71 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476685 n.3028A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476694 n.3037G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476699 n.3042A>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833850 c.309C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833859 c.318C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.13 pyrazinamide
rpsA 1833877 c.336C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.19 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.22 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.21 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.12 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.14 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834307 p.Asp256Asn missense_variant 0.13 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.17 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>T synonymous_variant 0.15 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.15 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.16 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.19 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834627 c.1086C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.14 pyrazinamide
rpsA 1834636 c.1095C>G synonymous_variant 0.13 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.12 pyrazinamide
tsnR 1853674 c.69G>A synonymous_variant 1.0 linezolid Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102990 p.Val18Ala missense_variant 1.0 isoniazid Not assoc w R
delamanid Uncertain significance
ethionamide Uncertain significance
PPE35 2169840 p.Gly258Asp missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
ribD 2986827 c.-12G>A upstream_gene_variant 1.0 para-aminosalicylic_acid
Rv2752c 3064993 p.Trp400* stop_gained 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
fbiD 3339287 p.Arg57Leu missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
Rv3083 3448608 c.105G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3236c 3612665 p.Val151Ala missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 0.99 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3877704 c.804G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877734 c.774G>C synonymous_variant 0.12 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.12 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.12 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
clpC1 4038767 c.1938G>T synonymous_variant 0.13 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.12 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.12 pyrazinamide
clpC1 4038795 p.Ser637Thr missense_variant 0.12 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038899 c.1806C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.14 pyrazinamide
clpC1 4038926 c.1779G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038932 c.1773G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039010 c.1695G>A synonymous_variant 0.2 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039067 c.1638G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039139 c.1566G>A synonymous_variant 0.13 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.13 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.12 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.13 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039634 p.Glu357Asn missense_variant 0.16 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.18 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.15 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.13 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.12 pyrazinamide
embC 4238963 c.-900C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4239274 c.-589C>G upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269308 p.Phe176Leu missense_variant 1.0 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin