TB-Profiler result

Run: ERR760733
Summary

Run ID: ERR760733

Sample name:

Date: 2024-04-16T00:20:14.638922

Number of reads: 5642338

Percentage reads mapped: 74.12

Median coverage: 123.0

Strain: lineage4.1.2.1.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.97
lineage4.1.2 Euro-American None 0.98
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.97
lineage4.1.2.1.1 Euro-American (Haarlem) RD182 0.96
lineage4 Euro-American None 0.94
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Ser450Leu Assoc w R
isoniazid katG p.Ile335Thr Mutation from literature
p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.His312Arg Mutation from literature
p.Gly406Ala Assoc w R
pyrazinamide pncA p.Gln10Pro Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
gid c.329_330delTG Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1401A>G Assoc w R
capreomycin rrs n.1401A>G Assoc w R
kanamycin rrs n.1401A>G Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.17 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.2 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761155 p.Ser450Leu missense_variant 0.72 rifampicin Assoc w R
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.35 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.18 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance Mutation from literature
rrs 1473246 n.1401A>G non_coding_transcript_exon_variant 0.79 capreomycin Assoc w R
amikacin Assoc w R
kanamycin Assoc w R
katG 2155108 p.Ile335Thr missense_variant 0.17 isoniazid Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 0.94 isoniazid Assoc w R High-level resistance
pncA 2289213 p.Gln10Pro missense_variant 0.99 pyrazinamide Assoc w R
embB 4247448 p.His312Arg missense_variant 0.25 ethambutol Mutation from literature
embB 4247730 p.Gly406Ala missense_variant 0.98 ethambutol Assoc w R
gid 4407872 c.329_330delTG frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 571 c.571T>C synonymous_variant 0.18 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.17 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.18 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.17 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.16 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.15 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.18 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.15 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.15 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.16 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.17 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.18 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.15 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.16 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.16 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.16 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.16 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.16 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.17 isoniazid
dnaA 1419 c.1419C>G synonymous_variant 0.17 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.2 isoniazid
gyrB 6169 c.930C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.2 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6862 c.1623C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7862 c.561C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8081 c.780A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8084 c.783G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8099 c.798T>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9281 c.1980C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9647 c.2346C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9677 c.2376C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9701 c.2400T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13890 c.-332T>C upstream_gene_variant 0.16 isoniazid
Rv0010c 13893 c.-335T>G upstream_gene_variant 0.15 isoniazid
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.2 isoniazid
Rv0010c 13909 c.-351G>C upstream_gene_variant 0.2 isoniazid
fgd1 490803 c.21T>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490833 c.51G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490842 c.60C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491502 c.720G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491583 c.801G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491591 p.Lys270Met missense_variant 0.84 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575659 c.312A>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.16 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575679 p.Asn111Ser missense_variant 0.84 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575689 c.342G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.23 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.24 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.23 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.2 ethionamide
isoniazid
ccsA 619579 c.-312G>C upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.21 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.15 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620604 c.714C>G synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620622 c.732G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620762 p.Lys291Met missense_variant 0.16 capreomycin
amikacin
kanamycin
Rv0565c 656872 p.Thr200Ser missense_variant 0.16 ethionamide
Rv0565c 656880 c.591C>G synonymous_variant 0.16 ethionamide
Rv0565c 656883 c.586_588delATCinsCG frameshift_variant&missense_variant 0.17 ethionamide Uncertain significance
Rv0565c 656889 c.582A>G synonymous_variant 0.16 ethionamide
Rv0565c 656901 c.570C>G synonymous_variant 0.16 ethionamide
Rv0565c 656934 c.537C>G synonymous_variant 0.16 ethionamide
Rv0565c 657269 p.Ser68Pro missense_variant 0.89 ethionamide Uncertain significance
Rv0565c 657602 c.-132C>G upstream_gene_variant 0.15 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.23 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.23 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.23 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.24 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.21 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.18 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.19 ethionamide
Rv0565c 657719 c.-249C>G upstream_gene_variant 0.16 ethionamide
hadA 731792 c.-138G>A upstream_gene_variant 0.15 isoniazid
hadA 732253 c.324T>C synonymous_variant 0.16 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.17 isoniazid
hadA 732270 p.Glu114Val missense_variant 0.17 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.17 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.17 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.17 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.17 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.17 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.16 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.19 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.18 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.16 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.16 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.17 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.16 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.16 isoniazid
nusG 734407 p.Val52Ile missense_variant 0.14 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.16 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.18 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.16 rifampicin
nusG 734481 c.228C>G synonymous_variant 0.16 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.17 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.21 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734595 c.342C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
nusG 734610 c.357C>G synonymous_variant 0.16 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.15 rifampicin Uncertain significance
nusG 734820 c.567A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.19 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.19 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.21 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.21 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.2 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.18 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.22 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.2 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.19 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.17 rifampicin
rpoB 760106 c.300G>T synonymous_variant 0.14 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.85 rifampicin Not assoc w R
rpoB 760130 p.Asp108Glu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.21 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.26 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.26 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.27 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.27 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.28 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.29 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.29 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760514 c.708C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.18 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.19 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.23 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.17 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.17 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.17 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.17 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.24 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.25 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.26 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.22 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.23 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.26 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.23 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.25 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.27 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.21 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>A synonymous_variant 0.21 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.18 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.15 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.2 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.26 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761765 c.1959T>C synonymous_variant 0.16 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.16 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.18 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.17 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.17 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.17 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.17 rifampicin
rpoB 761847 p.Cys681Ser missense_variant 0.17 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.16 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.15 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.15 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.18 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.17 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.17 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.15 rifampicin Uncertain significance
rpoB 762167 c.2361T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.24 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.27 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.17 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.16 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.17 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.19 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.19 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.21 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.2 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.2 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.2 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.22 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.23 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.24 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.28 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.17 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.17 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.15 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.22 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.23 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.21 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.25 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.27 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.27 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.27 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.24 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.24 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.2 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.2 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.23 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.25 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.23 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.22 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.24 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.23 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.24 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.26 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.23 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.23 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.24 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.24 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.22 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.2 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.21 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.22 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.24 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.27 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.27 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.27 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.25 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.26 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.2 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.22 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.17 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.18 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.18 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.16 rifampicin
rpoC 764398 c.1029G>C synonymous_variant 0.19 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.14 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.16 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTG frameshift_variant&missense_variant 0.18 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.19 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.3 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.22 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.27 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.23 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.23 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.17 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.99 rifampicin Not assoc w R
rpoC 765349 c.1980T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765404 p.Leu679Val missense_variant 0.16 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.16 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.16 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.17 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.17 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765535 c.2166C>T synonymous_variant 0.27 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.26 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.26 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.28 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.28 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.28 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.24 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.22 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.18 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.17 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.2 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.19 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.17 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.25 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.24 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.16 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766010 p.Ser881Thr missense_variant 0.14 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.16 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.2 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.17 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.2 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.19 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.21 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.21 rifampicin
rpoC 766108 p.Asp913Glu missense_variant 0.19 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.14 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.16 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.18 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.18 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.18 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.18 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.18 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.19 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.18 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.17 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.16 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.19 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.17 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.17 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.2 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.26 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.19 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.19 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.21 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.16 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.24 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.24 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.25 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.25 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.24 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.24 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.24 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.25 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.18 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.15 rifampicin
rpoC 767230 c.3861G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775864 p.Ala873Ser missense_variant 0.19 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsTG frameshift_variant&missense_variant 0.23 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>C synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 775898 c.2583G>A synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 775901 c.2580G>A synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.27 clofazimine
bedaquiline
mmpL5 775912 c.2569C>A synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.29 clofazimine
bedaquiline
mmpL5 775970 c.2511G>C synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775975 c.2506T>C synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.33 clofazimine
bedaquiline
mmpL5 775991 c.2490G>A synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.28 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776005 p.Ile826Leu missense_variant 0.21 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 776053 c.2428T>C synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 0.15 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777158 c.1323C>G synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 777203 c.1278G>C synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 777214 p.Ala423Thr missense_variant 0.17 clofazimine
bedaquiline
mmpL5 777793 p.Ala230Thr missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.17 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.2 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.21 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.23 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.21 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.23 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.22 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.23 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.22 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.23 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.23 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.23 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.22 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.22 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.22 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.22 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.23 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.23 streptomycin Uncertain significance
rplC 800537 c.-272C>T upstream_gene_variant 0.17 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.17 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.2 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.23 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.25 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.29 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.31 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.32 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.31 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.27 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.26 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.24 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.24 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.22 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.21 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.15 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.15 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.14 linezolid
rplC 800817 c.9A>T synonymous_variant 0.14 linezolid
rplC 801222 c.414T>C synonymous_variant 0.15 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.17 linezolid
fbiC 1303686 c.756C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303743 c.813C>T synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303746 c.816T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.36 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.15 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305311 p.Arg794Gln missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
sigE 1364862 c.450C>G synonymous_variant 0.16 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.16 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 0.16 pyrazinamide Uncertain significance
atpE 1461132 p.Val30Ile missense_variant 0.18 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.2 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.2 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.22 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.24 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.22 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.23 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.22 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.15 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
inhA 1673547 c.-655T>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.18 ethionamide
isoniazid Uncertain significance
inhA 1673619 c.-583T>C upstream_gene_variant 0.16 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.16 ethionamide
isoniazid
inhA 1674315 c.114C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674321 c.120G>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674342 c.141T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674513 c.312C>T synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674540 c.339C>T synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.22 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.28 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674693 c.492C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 0.16 ethionamide
isoniazid
rpsA 1833541 c.-1T>C upstream_gene_variant 0.17 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.26 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.3 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.26 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.21 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834097 p.Ser186Thr missense_variant 0.16 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.22 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.25 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.27 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.24 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.24 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.22 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.2 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.22 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.2 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.26 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.26 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.28 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.29 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.29 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.29 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.26 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.26 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.25 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.22 linezolid
tsnR 1853484 c.-122_-121delAGinsGC upstream_gene_variant 0.22 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2101960 c.1083A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101966 c.1077T>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101978 c.1063_1065delAACinsGT frameshift_variant&missense_variant 0.2 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101988 p.Ala352Gly missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102009 p.Ser345Asn missense_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102020 c.1023A>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102050 c.993T>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102053 c.990G>C synonymous_variant 0.19 ethionamide
delamanid
isoniazid
katG 2155054 p.Tyr353Phe missense_variant 0.17 isoniazid
katG 2155056 c.1056A>G synonymous_variant 0.17 isoniazid
katG 2155065 c.1047C>G synonymous_variant 0.16 isoniazid
katG 2155068 c.1044T>C synonymous_variant 0.17 isoniazid
katG 2155071 c.1041T>C synonymous_variant 0.17 isoniazid
katG 2155080 c.1032G>C synonymous_variant 0.21 isoniazid
katG 2155632 c.480A>C synonymous_variant 0.22 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.22 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.23 isoniazid Uncertain significance
katG 2155677 c.435C>G synonymous_variant 0.2 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.2 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.18 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.18 isoniazid
katG 2155701 c.411C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
katG 2155704 c.408C>G synonymous_variant 0.18 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.15 isoniazid
PPE35 2169751 p.Gly288* stop_gained 0.98 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289991 c.-750G>C upstream_gene_variant 0.16 pyrazinamide
pncA 2290006 c.-765T>C upstream_gene_variant 0.18 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.19 pyrazinamide
pncA 2290015 c.-774A>C upstream_gene_variant 0.19 pyrazinamide
pncA 2290027 c.-786G>A upstream_gene_variant 0.18 pyrazinamide
pncA 2290030 c.-791_-789delAATinsCC upstream_gene_variant 0.18 pyrazinamide
pncA 2290033 c.-792C>G upstream_gene_variant 0.19 pyrazinamide
pncA 2290038 c.-797G>T upstream_gene_variant 0.2 pyrazinamide
pncA 2290042 c.-801T>C upstream_gene_variant 0.19 pyrazinamide
kasA 2517947 c.-168C>T upstream_gene_variant 0.22 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.2 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.17 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.18 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 0.99 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.16 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.18 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.2 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.19 isoniazid
kasA 2518222 c.108G>A synonymous_variant 0.15 isoniazid
kasA 2518225 p.Leu37Phe missense_variant 0.16 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.16 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.16 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.21 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.17 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.16 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.17 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.18 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.18 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.21 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.19 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.23 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.22 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.24 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.23 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.21 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.19 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.2 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.2 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.2 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.2 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.2 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.18 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.21 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.18 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.19 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.19 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.22 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.21 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.18 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.17 isoniazid
ahpC 2726336 c.144G>C synonymous_variant 0.15 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.21 isoniazid
ahpC 2726354 c.162G>C synonymous_variant 0.19 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ahpC 2726366 c.174G>C synonymous_variant 0.16 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.15 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.18 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.19 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.19 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.19 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.19 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.18 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.17 isoniazid
folC 2747023 c.576C>G synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747032 c.567A>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747040 p.Ile187Val missense_variant 0.18 para-aminosalicylic_acid
folC 2747059 c.540T>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747065 c.534C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747086 c.513A>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747098 c.501C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747101 c.498G>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747281 c.318A>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.18 para-aminosalicylic_acid
folC 2747290 c.309A>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.2 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.16 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.16 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783015 p.Ser343Thr missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783116 c.927T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783236 c.807G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783578 p.Glu155Asp missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784366 c.-324G>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784375 c.-333T>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784381 c.-339T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784455 c.-413A>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.27 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.2 capreomycin
Rv2752c 3065040 c.1152C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065979 c.213T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.15 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066024 c.168T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066118 p.Asn25Ser missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066134 p.Ala20Ser missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066300 c.-109G>A upstream_gene_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066309 c.-118T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066336 c.-145C>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066342 c.-151G>A upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066345 c.-154C>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066350 c.-159T>A upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-565G>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066759 c.-568G>A upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066765 c.-574G>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066797 c.-606C>T upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067304 c.642A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067463 c.481_483delATCinsGA frameshift_variant&missense_variant 0.16 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.14 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073812 c.660C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073824 c.648A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073844 p.Asp210His missense_variant 0.22 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.22 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.2 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.14 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624107 c.804C>T synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624124 p.Leu263Val missense_variant 0.18 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.19 bedaquiline
rifampicin
lpqB 3624172 p.Val247Ile missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624173 c.738A>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624194 c.717C>A synonymous_variant 0.14 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ala missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624452 c.459T>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624476 c.435C>G synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.2 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.156A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624760 c.151C>T synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624770 c.141T>C synonymous_variant 0.15 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 0.99 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625572 p.Thr348Ser missense_variant 0.14 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.15 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625735 c.879C>A synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.19 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.22 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.17 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627170 c.-557C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627227 c.123T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627299 p.Leu17Phe missense_variant 0.17 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.16 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.2 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877581 c.927G>A synonymous_variant 0.21 rifampicin
rpoA 3877584 c.924C>G synonymous_variant 0.21 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.19 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.25 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.24 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.2 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.21 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.18 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.16 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.17 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.17 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.2 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.17 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.17 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.18 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.21 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.17 rifampicin
rpoA 3878337 c.171T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.15 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.16 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.19 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.2 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.23 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.23 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.21 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.18 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.17 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.17 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.16 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.19 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.16 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.18 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.2 rifampicin
rpoA 3878826 c.-319A>T upstream_gene_variant 0.15 rifampicin
rpoA 3878845 c.-338G>C upstream_gene_variant 0.15 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.16 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.18 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.19 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.23 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.2 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.16 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986655 c.-189A>T upstream_gene_variant 0.18 delamanid
pretomanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.15 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.15 delamanid
pretomanid
ddn 3986667 c.-177C>A upstream_gene_variant 0.14 delamanid
pretomanid
clpC1 4038278 c.2427T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.17 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038434 c.2271G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.22 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.27 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.27 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.25 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.2 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.17 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.16 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038851 c.1854G>A synonymous_variant 0.24 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.27 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.23 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039484 c.1221T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.16 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.21 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTG frameshift_variant&missense_variant 0.15 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.16 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.16 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040092 p.Ser205Thr missense_variant 0.15 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040264 c.441C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.16 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.19 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
panD 4044188 c.94T>C synonymous_variant 0.18 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.19 pyrazinamide
panD 4044213 c.69C>G synonymous_variant 0.15 pyrazinamide
panD 4044246 c.36C>G synonymous_variant 0.15 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.19 pyrazinamide
panD 4044748 c.-467G>A upstream_gene_variant 0.15 pyrazinamide
panD 4044749 c.-468G>A upstream_gene_variant 0.15 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.17 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.2 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044809 c.-528C>G upstream_gene_variant 0.2 pyrazinamide
panD 4044812 c.-531A>G upstream_gene_variant 0.18 pyrazinamide
panD 4044818 c.-537G>C upstream_gene_variant 0.17 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.2 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.22 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.22 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.22 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.25 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.21 pyrazinamide
panD 4045063 c.-782T>C upstream_gene_variant 0.2 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.18 pyrazinamide
glpK 4138502 c.1254T>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138518 p.Glu413Ala missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138538 c.1218C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138547 c.1209C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239298 c.-565C>T upstream_gene_variant 0.93 ethambutol Not assoc w R
embC 4239378 c.-485T>C upstream_gene_variant 0.16 ethambutol
embC 4240543 c.681G>C synonymous_variant 0.17 ethambutol
embC 4240561 c.699C>G synonymous_variant 0.15 ethambutol
embC 4240600 c.738G>C synonymous_variant 0.18 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.21 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.22 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.22 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.26 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.26 ethambutol
embC 4240685 c.823_825delACCinsGG frameshift_variant&missense_variant 0.25 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.25 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.21 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4240783 c.921G>C synonymous_variant 0.23 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.23 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.23 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.25 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.21 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.21 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.18 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.17 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.17 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.16 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.15 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.16 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.17 ethambutol
embC 4241443 c.1581C>G synonymous_variant 0.23 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.22 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.23 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.97 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.98 ethambutol Not assoc w R
embA 4245077 c.1845G>C synonymous_variant 0.18 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.19 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.19 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.21 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.21 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.2 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.21 ethambutol
embA 4245163 p.His644Arg missense_variant 0.22 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.17 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.17 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.17 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.18 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.21 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.23 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.25 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.22 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.19 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.18 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.18 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.15 ethambutol
embB 4247779 c.1266C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247785 c.1272G>C synonymous_variant 0.17 ethambutol
embB 4247800 c.1287A>C synonymous_variant 0.22 ethambutol
embB 4247806 c.1293G>C synonymous_variant 0.24 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.26 ethambutol
embB 4247824 c.1311C>G synonymous_variant 0.28 ethambutol
embB 4247830 c.1317A>C synonymous_variant 0.28 ethambutol
embB 4247836 c.1323A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247842 c.1329T>C synonymous_variant 0.27 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.21 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.19 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248064 c.1551G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.21 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.22 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.24 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.25 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.26 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.27 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.26 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.26 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.17 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.18 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.16 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.15 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.15 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.16 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.15 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.15 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.17 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.14 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin