TB-Profiler result

Run: SRR12006550
Summary

Run ID: SRR12006550

Sample name:

Date: 2024-04-14T00:45:36.509547

Number of reads: 2139999

Percentage reads mapped: 75.92

Median coverage: 69.0

Strain: lineage1.2.1.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.1.2 Indo-Oceanic RD239 0.96
lineage1 Indo-Oceanic RD239 0.88
lineage1.2.1 Indo-Oceanic RD239 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.916_918delTTCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303846 c.916_918delTTCinsGG frameshift_variant&missense_variant 0.17 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 756 c.756T>C synonymous_variant 0.16 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.15 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 807 c.807G>A synonymous_variant 0.17 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.18 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.17 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.17 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.17 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.16 isoniazid
gyrB 5969 p.His244Tyr missense_variant 1.0 levofloxacin
moxifloxacin
gyrB 6112 p.Met291Ile missense_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6215 p.Ser326Thr missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6248 c.1009C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.16 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7490 c.189C>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7523 c.222C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7535 c.234C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8138 c.837C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8177 c.876A>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8246 c.945C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8360 c.1059G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8452 p.Ala384Val missense_variant 0.91 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8502 c.1201C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8543 c.1242C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 p.Asp415Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8690 c.1389C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8818 p.Ser506Asn missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9197 c.1896G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9260 c.1959G>C synonymous_variant 0.83 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9275 c.1974G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9329 c.2028C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9338 c.2037G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
Rv0010c 13175 c.384T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575368 c.21T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R
ccsA 619570 c.-321G>C upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>A synonymous_variant 0.18 capreomycin
amikacin
kanamycin
Rv0565c 657337 p.Arg45Gln missense_variant 0.16 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
hadA 731732 c.-198G>A upstream_gene_variant 0.17 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.18 isoniazid
nusG 734116 c.-138T>C upstream_gene_variant 0.92 rifampicin Not assoc w R
nusG 734580 c.327T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.25 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.3 rifampicin
rpoB 760310 c.504G>T synonymous_variant 0.31 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.31 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.3 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.3 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.29 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.32 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.3 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.29 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.18 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760520 c.714C>G synonymous_variant 0.17 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.18 rifampicin Uncertain significance
rpoB 760547 c.741G>T synonymous_variant 0.2 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.18 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.23 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.24 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760710 c.904C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.31 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.28 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.3 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.29 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.26 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.26 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.25 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.27 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.28 rifampicin
rpoB 760850 c.1044G>A synonymous_variant 0.27 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.23 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.19 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.23 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.23 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.23 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.21 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.25 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.28 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.28 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.27 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.24 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.23 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761393 c.1587G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761492 c.1686G>C synonymous_variant 0.19 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.2 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.24 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.26 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.27 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761640 c.1834C>T synonymous_variant 0.23 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.22 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.2 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.16 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.16 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.18 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.18 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 0.18 rifampicin
rpoB 761870 p.Asp688Glu missense_variant 0.18 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.19 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.2 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.17 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.18 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.17 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.16 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.19 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.2 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.22 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.2 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762029 c.2223C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762035 c.2229G>C synonymous_variant 0.19 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.28 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.29 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.28 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.28 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.23 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.21 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.19 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.22 rifampicin
rpoB 762368 c.2562G>A synonymous_variant 0.22 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.27 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.26 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.3 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.3 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.31 rifampicin
rpoC 762449 c.-921C>G upstream_gene_variant 0.31 rifampicin
rpoB 762452 c.2646G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.23 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.23 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.23 rifampicin
rpoB 762750 p.Leu982Met missense_variant 0.2 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>C upstream_gene_variant 0.24 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.32 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.3 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.29 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.29 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.29 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 762920 c.-450C>G upstream_gene_variant 0.27 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.31 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.34 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.75 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.16 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.2 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.24 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763181 c.-189G>T upstream_gene_variant 0.23 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.21 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.21 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.21 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.21 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.17 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.2 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>C synonymous_variant 0.76 rifampicin Not assoc w R
rpoC 763546 c.177A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.21 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.2 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.21 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.21 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.19 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.17 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.17 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.21 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763835 p.Ala156Met missense_variant 0.23 rifampicin
rpoC 763852 c.483C>G synonymous_variant 0.21 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.19 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.21 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.21 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.19 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.2 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.8 rifampicin Not assoc w R
rpoC 763886 c.517_519delCGGinsAC frameshift_variant&missense_variant 0.78 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.19 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.2 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763906 c.537C>T synonymous_variant 0.2 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.23 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764002 c.633C>G synonymous_variant 0.16 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.19 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.16 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.18 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.18 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.18 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.19 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.22 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.23 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.25 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.23 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.22 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.27 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.22 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.23 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.23 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.25 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764308 c.939G>C synonymous_variant 0.25 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.27 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.24 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764401 c.1032C>T synonymous_variant 0.22 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.22 rifampicin
rpoC 764413 c.1044C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.21 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764437 c.1068G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.18 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.18 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.2 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.2 rifampicin
rpoC 764515 c.1146C>T synonymous_variant 0.18 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.15 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.24 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.2 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.28 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.3 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.24 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.21 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.27 rifampicin
rpoC 764932 c.1563C>G synonymous_variant 0.26 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.23 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>T synonymous_variant 0.21 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.19 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.2 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.16 rifampicin
rpoC 765121 c.1752G>T synonymous_variant 0.16 rifampicin
rpoC 765370 c.2001G>T synonymous_variant 0.17 rifampicin
rpoC 765371 c.2002C>T synonymous_variant 0.17 rifampicin
rpoC 765379 c.2010G>T synonymous_variant 0.17 rifampicin
rpoC 765383 c.2014_2016delATGinsCT frameshift_variant&missense_variant 0.17 rifampicin
rpoC 765391 c.2022C>T synonymous_variant 0.15 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.16 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.19 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.19 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.2 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.23 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.29 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.3 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.26 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.25 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.25 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.25 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.23 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.2 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.19 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.24 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.24 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.26 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.24 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.23 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.25 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.28 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.28 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>G synonymous_variant 0.27 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.19 rifampicin
rpoC 766027 c.2658G>T synonymous_variant 0.18 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.17 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.16 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.15 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.16 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.16 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.16 rifampicin
rpoC 766288 c.2919C>T synonymous_variant 0.2 rifampicin
rpoC 766294 c.2925C>T synonymous_variant 0.21 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.26 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.28 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.31 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.26 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.29 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.29 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.29 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.29 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.3 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.28 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.26 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.18 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.18 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.21 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.19 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.2 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.2 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.21 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.23 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.22 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.2 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.21 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.26 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.27 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.27 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.27 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.23 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.26 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.28 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.24 rifampicin
rpoC 766801 c.3432C>A synonymous_variant 0.23 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.2 rifampicin
rpoC 766879 c.3510G>C synonymous_variant 0.21 rifampicin
rpoC 766888 c.3519G>C synonymous_variant 0.22 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.21 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.19 rifampicin
rpoC 766900 c.3531T>G synonymous_variant 0.21 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.2 rifampicin
rpoC 766907 c.3538C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766918 c.3549C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.21 rifampicin
rpoC 766924 p.Glu1185Asp missense_variant 0.21 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.25 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766951 c.3582G>C synonymous_variant 0.16 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>A synonymous_variant 0.19 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.21 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246His missense_variant 0.16 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.22 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.21 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.26 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.27 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.26 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.25 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.24 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.24 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.23 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.2 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.23 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.23 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.22 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.24 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.28 streptomycin
rpsL 781859 c.300T>A synonymous_variant 0.26 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.24 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.28 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.31 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.29 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.27 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
rplC 800591 c.-218C>T upstream_gene_variant 0.17 linezolid
rplC 800594 c.-215C>T upstream_gene_variant 0.16 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.17 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.17 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.21 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.25 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.2 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.19 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.17 linezolid
rplC 800856 c.48A>G synonymous_variant 0.17 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.17 linezolid
rplC 800889 c.81C>G synonymous_variant 0.16 linezolid
rplC 800904 c.96G>C synonymous_variant 0.17 linezolid
rplC 801228 c.420T>C synonymous_variant 0.18 linezolid
rplC 801249 c.441T>C synonymous_variant 0.17 linezolid
rplC 801255 c.447C>T synonymous_variant 0.17 linezolid
rplC 801258 c.450C>G synonymous_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303534 p.Ser202Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303599 c.669C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303647 c.717G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303653 c.723G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303827 c.897A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303869 c.939T>C synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303878 c.948G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303897 c.967C>T synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303913 p.Gly328Ala missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303935 c.1005G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>A synonymous_variant 0.17 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304655 c.1725C>T synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304658 c.1728C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Glu missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305027 c.2097G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
sigE 1364766 c.354C>T synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
sigE 1364919 c.507T>C synonymous_variant 0.16 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.15 pyrazinamide
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
atpE 1460907 c.-138T>C upstream_gene_variant 0.93 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673499 c.-703T>C upstream_gene_variant 0.19 ethionamide
isoniazid Uncertain significance
inhA 1673505 c.-697A>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673535 c.-667A>G upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673547 c.-655T>C upstream_gene_variant 0.19 ethionamide
isoniazid
fabG1 1673569 p.Val44Ile missense_variant 0.22 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1674561 c.360C>T synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.21 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.22 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674639 c.438C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCC frameshift_variant&missense_variant 0.24 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.23 ethionamide
isoniazid
inhA 1674753 c.552G>T synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.21 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674780 c.579T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674789 c.588G>A synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.23 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674837 c.636C>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.19 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.19 ethionamide
isoniazid
rpsA 1833589 c.48A>T synonymous_variant 0.2 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.2 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833772 c.231C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833844 c.303C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833931 c.390C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.24 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834210 c.669C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834321 c.780C>A synonymous_variant 0.31 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.27 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834543 c.1002C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.19 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.22 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.23 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834775 p.Ala412Asn missense_variant 0.21 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.19 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.22 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.22 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.22 linezolid
tsnR 1853387 c.-219T>C upstream_gene_variant 0.17 linezolid
tsnR 1853390 c.-216G>T upstream_gene_variant 0.17 linezolid
tsnR 1853395 c.-211T>C upstream_gene_variant 0.15 linezolid
tsnR 1853974 c.369C>T synonymous_variant 0.98 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.22 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.17 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.16 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.16 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.16 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.26 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.25 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.23 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.22 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.22 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.23 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.24 isoniazid
kasA 2518618 c.504G>C synonymous_variant 0.24 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.25 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.27 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.27 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.26 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.25 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.25 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.25 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.25 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.25 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.2 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.24 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.24 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.21 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.23 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.25 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.21 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.2 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.17 isoniazid
kasA 2519048 p.Gly312Ser missense_variant 0.97 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
Rv2477c 2782957 c.1086A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783038 c.1003_1005delGCCinsAT frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783086 c.957C>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783122 c.921G>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.33 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783266 c.777C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783658 c.385C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783695 c.348C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Gly missense_variant 0.17 ethambutol Uncertain significance
moxifloxacin
streptomycin Uncertain significance
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067382 c.564C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067433 c.513C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067463 c.481_483delATCinsCG frameshift_variant&missense_variant 0.23 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067469 p.Asn159Ser missense_variant 0.22 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067510 c.436C>T synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.24 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.24 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.21 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.21 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.2 para-aminosalicylic_acid
thyX 3067559 p.Arg129Gln missense_variant 0.19 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.19 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.21 para-aminosalicylic_acid
thyX 3067586 c.360C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.2 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.21 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067844 c.102G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073889 p.Ser195Ala missense_variant 0.23 para-aminosalicylic_acid
thyA 3073890 c.580_582delTTGinsCC frameshift_variant&missense_variant 0.23 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.28 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074007 c.465C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.21 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
fbiD 3339417 c.300A>G synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
whiB7 3568488 c.191delG frameshift_variant 1.0 streptomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
lpqB 3623512 p.Gly467Ser missense_variant 0.2 bedaquiline
rifampicin
lpqB 3623519 c.1392C>T synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3623528 c.1383G>T synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3623531 p.Gly460Ala missense_variant 0.21 bedaquiline
rifampicin
lpqB 3623552 c.1359G>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623555 c.1354_1356delGGGinsAC frameshift_variant&missense_variant 0.19 bedaquiline
rifampicin Uncertain significance
lpqB 3623561 c.1350T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3623570 c.1341A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623573 c.1338T>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623580 p.Asn444Thr missense_variant 0.18 bedaquiline
rifampicin
lpqB 3623587 p.Ala442Pro missense_variant 0.16 bedaquiline
rifampicin
lpqB 3623597 c.1314C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3623612 p.Thr433Val missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624242 c.669A>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624245 c.666A>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624254 c.657T>C synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624701 c.210T>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624716 c.195G>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624722 c.189C>G synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625616 p.Arg333Ala missense_variant 0.16 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.22 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625683 c.-773C>T upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.3 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.25 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625798 c.-888G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625858 c.-948C>A upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625864 c.-954T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625867 c.747A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625876 c.738G>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625909 c.-999T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625927 c.687T>C synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625930 c.684C>G synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3626390 p.Arg75Lys missense_variant 0.16 bedaquiline
rifampicin
mtrB 3626400 p.Ile72Val missense_variant 0.17 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626708 c.642G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626711 c.-98T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626720 c.-107G>A upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626735 c.-122C>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626744 c.-131G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.25 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626890 c.-277T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626924 c.-311G>A upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626990 c.-377G>T upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627023 c.-410C>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627083 c.-470G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627221 c.129C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
fbiA 3640557 c.15T>C synonymous_variant 0.96 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.21 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.2 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.18 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.33 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.24 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.24 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.22 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.23 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.23 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.24 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.28 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.35 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.35 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.36 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.36 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.37 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.39 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.39 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.4 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.42 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.45 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.48 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.51 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.48 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.48 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.47 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.47 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.46 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.46 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.45 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>G synonymous_variant 0.37 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.34 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878232 c.276G>C synonymous_variant 0.28 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.25 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.24 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.28 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.29 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.38 rifampicin
rpoA 3878361 c.147G>C synonymous_variant 0.33 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.33 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.31 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.27 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.28 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.29 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.3 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.3 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.3 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.36 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.36 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.37 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.32 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878797 c.-290G>A upstream_gene_variant 0.26 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.27 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.25 rifampicin
rpoA 3878837 c.-331_-330delAAinsGG upstream_gene_variant 0.22 rifampicin
rpoA 3878839 c.-332C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878845 c.-338G>T upstream_gene_variant 0.24 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.23 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.27 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.21 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.21 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878953 c.-446C>T upstream_gene_variant 0.21 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.19 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.22 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.22 rifampicin
rpoA 3879033 c.-526C>T upstream_gene_variant 0.25 rifampicin
rpoA 3879034 c.-527G>A upstream_gene_variant 0.25 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.21 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.26 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.29 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.31 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.26 rifampicin
clpC1 4038239 c.2466T>A synonymous_variant 0.2 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.17 pyrazinamide
clpC1 4038271 p.Pro812Ser missense_variant 0.18 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.18 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.16 pyrazinamide
clpC1 4038461 c.2244G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.22 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.23 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.23 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038683 c.2022T>G synonymous_variant 0.25 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038752 c.1953G>A synonymous_variant 0.23 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.23 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038881 c.1824C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038884 c.1821C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038911 c.1794G>A synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038914 c.1791G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.17 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039130 c.1575C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039339 p.Thr456Pro missense_variant 0.16 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.17 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.22 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039934 c.771G>T synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.17 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040249 c.456A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040300 c.405C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040369 c.336C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040517 p.Val63Ala missense_variant 0.92 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138565 c.1191G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138667 c.1089G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138682 c.1074C>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354His missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139249 c.507C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139255 c.501G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139285 c.471A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139312 c.444T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139324 c.432A>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139330 c.426G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240780 c.918T>C synonymous_variant 0.2 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.19 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.19 ethambutol
embC 4240801 c.939C>T synonymous_variant 0.21 ethambutol
embC 4240813 p.Phe317Leu missense_variant 0.23 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.22 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.22 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.24 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.25 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.23 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.22 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.22 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.21 ethambutol
embC 4240886 p.Ile342Val missense_variant 0.21 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.17 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.17 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.91 ethambutol Not assoc w R
embC 4241071 c.1209C>G synonymous_variant 0.15 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.16 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4243580 c.348G>A synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244420 c.1188G>C synonymous_variant 0.94 ethambutol Not assoc w R
embB 4245764 c.-750G>C upstream_gene_variant 0.16 ethambutol
embA 4245772 p.Asn847Thr missense_variant 0.17 ethambutol
embA 4245785 c.2553G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embA 4245852 p.Ala874Ser missense_variant 0.15 ethambutol
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embA 4246299 p.Ser1023Ala missense_variant 0.16 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.16 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.17 ethambutol
embB 4247485 c.972C>T synonymous_variant 0.17 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.18 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.21 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.2 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.19 ethambutol
embB 4247544 p.Ser344Thr missense_variant 0.15 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.15 ethambutol
embB 4247578 c.1065G>A synonymous_variant 0.92 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247776 c.1263G>C synonymous_variant 0.17 ethambutol
embB 4247785 c.1272G>C synonymous_variant 0.17 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.17 ethambutol
embB 4247800 c.1287A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247803 c.1290G>C synonymous_variant 0.18 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.17 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.17 ethambutol
embB 4247827 c.1314C>G synonymous_variant 0.17 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247842 c.1329T>C synonymous_variant 0.16 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.21 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.23 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.23 ethambutol
embB 4247908 c.1395C>T synonymous_variant 0.17 ethambutol
embB 4247909 c.1396T>C synonymous_variant 0.17 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247917 c.1404C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247923 c.1410T>C synonymous_variant 0.18 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.21 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.21 ethambutol
embB 4247951 c.1438_1440delTCGinsGC frameshift_variant&missense_variant 0.24 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247965 c.1452C>G synonymous_variant 0.22 ethambutol
embB 4247968 c.1455C>G synonymous_variant 0.22 ethambutol
embB 4248007 c.1494C>T synonymous_variant 0.25 ethambutol
embB 4248019 c.1506G>A synonymous_variant 0.19 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.16 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338361 p.Arg54Gln missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R