TB-Profiler result

Run: SRR12708399
Summary

Run ID: SRR12708399

Sample name:

Date: 2024-04-14T19:38:21.268521

Number of reads: 933256

Percentage reads mapped: 54.91

Median coverage: 28.0

Strain: lineage4.3.4.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.99
lineage4 Euro-American None 1.0
lineage4.3.4.2.1 Euro-American (LAM) RD174 0.97
lineage4.3.4 Euro-American (LAM) RD174 0.99
lineage4.3.4.2 Euro-American (LAM) RD174 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1297_1299dupTTC Assoc w R
c.1297_1299dupTTC Mutation from literature
c.1297_1299dupTTC Assoc w R
c.1297_1299dupTTC Mutation from literature
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761102 c.1297_1299dupTTC conservative_inframe_insertion 0.5 rifampicin Assoc w R
rifampicin Mutation from literature
rpoB 761102 c.1297_1299dupTTC conservative_inframe_insertion 0.5 rifampicin Assoc w R
rifampicin Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 763 p.Lys255Arg missense_variant 0.19 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.18 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.22 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.21 isoniazid
dnaA 804 c.804G>C synonymous_variant 0.22 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.22 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.21 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
gyrB 6140 p.Val301Leu missense_variant 0.96 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 6730 c.-572A>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6772 c.1533C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.22 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7084 c.-218A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7547 c.246C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7589 c.288G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
nusG 734460 c.207G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734807 p.Tyr185Phe missense_variant 0.27 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.28 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.23 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.24 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.25 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.26 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.28 rifampicin
rpoB 759445 c.-362T>G upstream_gene_variant 1.0 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760181 c.375T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.13 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.19 rifampicin Uncertain significance
rpoB 760460 c.654G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.25 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.19 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.18 rifampicin
rpoB 760910 c.1104C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.52 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.45 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.5 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.5 rifampicin
rpoB 761133 c.1327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.27 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.27 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761955 p.Ile717Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762026 c.2220G>C synonymous_variant 0.2 rifampicin
rpoB 762029 c.2223C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 762140 c.2334G>C synonymous_variant 0.24 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.23 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.2 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.16 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.17 rifampicin
rpoC 762956 c.-414G>C upstream_gene_variant 0.16 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.22 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763052 c.-318G>C upstream_gene_variant 0.25 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.18 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763193 c.3387C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763507 c.138G>C synonymous_variant 0.28 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.34 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.38 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.5 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.41 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.49 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.5 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.38 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.38 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.41 rifampicin
rpoC 763786 c.417C>G synonymous_variant 0.32 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.3 rifampicin
rpoC 763796 c.427_429delATGinsCC frameshift_variant&missense_variant 0.3 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.24 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.19 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.18 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.19 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.23 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.22 rifampicin
rpoC 764054 c.685C>T synonymous_variant 0.25 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.24 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.26 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.26 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.26 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.26 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.25 rifampicin
rpoC 764239 c.870T>C synonymous_variant 0.24 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.27 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764534 c.1165_1167delCGGinsAC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.3 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.23 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.24 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.24 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.19 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.19 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.4 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.39 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489_1491delTTGinsCC frameshift_variant&missense_variant 0.38 rifampicin
rpoC 764869 c.1500C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.82 rifampicin Not assoc w R
rpoC 765841 c.2472G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765861 p.Phe831Tyr missense_variant 0.21 rifampicin Uncertain significance
rpoC 765875 p.Val836Ile missense_variant 0.22 rifampicin Uncertain significance
rpoC 765907 c.2538G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766960 c.3591C>T synonymous_variant 0.15 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>A synonymous_variant 0.17 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767017 c.3648C>G synonymous_variant 0.18 rifampicin
rpoC 767035 c.3666G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.18 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.21 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767093 c.3724_3726delAGCinsTCG synonymous_variant 0.19 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.16 rifampicin
rpoC 767113 c.3744G>C synonymous_variant 0.17 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767152 c.3783T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767173 c.3804C>G synonymous_variant 0.17 rifampicin
rpoC 767180 p.Ala1271Thr missense_variant 0.2 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781766 c.207C>T synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.22 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.28 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.32 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.35 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.4 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.33 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.37 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.35 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.33 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.29 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.31 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.32 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.26 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.26 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.3 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.24 streptomycin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471997 n.152T>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472027 n.182C>T non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472057 n.212C>A non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472068 n.223T>C non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472069 n.224G>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>T non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472495 n.650C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474153 n.496C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474166 n.509G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404_1408delCAAGGinsAAGA non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475201 n.1544G>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475756 n.2099_2112delTAACCCGCAAGGGTinsCAGCCACTTCGGTGGC non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476091 n.2434_2435insC non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.4 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867delCinsGA non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833589 c.48A>C synonymous_variant 0.18 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.18 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.22 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.4 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.44 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.19 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.21 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.39 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.19 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.39 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.56 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.51 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.56 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.56 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.25 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834073 p.Lys178Arg missense_variant 0.22 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>T synonymous_variant 0.29 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.33 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>G synonymous_variant 0.15 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.22 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.19 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626704 c.-91C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626756 c.594C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626786 c.564A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626822 p.Asp176Glu missense_variant 0.17 bedaquiline
rifampicin
mtrA 3626825 c.525T>A synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626831 c.-218T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
rpoA 3877656 c.852T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877797 c.711G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877824 c.684G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>A synonymous_variant 0.3 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.27 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878070 c.438T>C synonymous_variant 0.15 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.14 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.14 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.17 rifampicin
rpoA 3878142 p.Gly122Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878193 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.18 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4038812 c.1893T>C synonymous_variant 0.91 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039010 c.1695G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039031 c.1674T>A synonymous_variant 0.29 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039043 c.1662G>T synonymous_variant 0.29 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.22 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 0.2 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.31 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.36 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>A synonymous_variant 0.28 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.34 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.3 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039619 c.1086G>A synonymous_variant 0.24 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.38 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039733 c.972G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.41 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.24 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039955 c.748_750delCTGinsTC frameshift_variant&synonymous_variant 0.26 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.21 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040456 c.249C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040465 c.240T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.19 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.24 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.24 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.24 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R