TB-Profiler result

Run: SRR7236177
Summary

Run ID: SRR7236177

Sample name:

Date: 2024-03-24T17:42:36.723154

Number of reads: 756062

Percentage reads mapped: 58.77

Median coverage: 28.0

Strain: La1.8.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8 M.bovis None 1.0
La1.8.1 M.bovis None 0.99
La1 M.bovis None 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6406 c.1167C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7406 c.105G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7694 c.393A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7706 c.405C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7709 c.408G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7796 c.495G>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8285 c.984C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8407 p.Gln369Arg missense_variant 0.88 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8456 c.1155C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8876 c.1575C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9217 p.Asp639Ala missense_variant 0.92 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9317 c.2016G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9383 c.2082T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9407 c.2106C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
rpoB 760121 c.315T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760136 c.330G>A synonymous_variant 0.23 rifampicin
rpoB 760139 c.333A>T synonymous_variant 0.23 rifampicin
rpoB 760142 c.336C>G synonymous_variant 0.23 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.44 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.45 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.44 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.44 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.37 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.3 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.33 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.33 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.24 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.2 rifampicin Uncertain significance
rpoB 760533 p.Val243Thr missense_variant 0.16 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760805 c.999G>C synonymous_variant 0.22 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.24 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.26 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.28 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.29 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.29 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.29 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.29 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.28 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.29 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.28 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760958 c.1152G>C synonymous_variant 0.24 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.25 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.23 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.28 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.26 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>A synonymous_variant 0.19 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.24 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.23 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.23 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.36 rifampicin
rpoB 762287 c.2481C>T synonymous_variant 0.36 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.33 rifampicin
rpoB 762338 c.2532T>C synonymous_variant 0.24 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.24 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.27 rifampicin
rpoB 762350 c.2544C>T synonymous_variant 0.27 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.26 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.29 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 0.19 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.3 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.16 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.21 rifampicin
rpoC 763414 c.45T>C synonymous_variant 0.2 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.2 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCT frameshift_variant&missense_variant 0.21 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.2 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.32 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.43 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.46 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.31 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.33 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.32 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.31 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.3 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.35 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.36 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.33 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.35 rifampicin
rpoC 763840 c.471G>T synonymous_variant 0.33 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.41 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.36 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.35 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.35 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.37 rifampicin
rpoC 763882 c.513G>A synonymous_variant 0.37 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.37 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.37 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.34 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.32 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.31 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.29 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.24 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.25 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.28 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.23 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.23 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.24 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764044 c.675T>C synonymous_variant 0.29 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.22 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.25 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.27 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.33 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.35 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.39 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.39 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.45 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.48 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.34 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.33 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.32 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.33 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.32 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.37 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.38 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.39 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.41 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.4 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 0.3 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.26 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.25 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.25 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.25 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.25 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765412 c.2043T>C synonymous_variant 0.18 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.21 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.16 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.19 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.2 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.21 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.19 rifampicin
rpoC 765533 p.Tyr722His missense_variant 0.19 rifampicin Uncertain significance
rpoC 765547 c.2178C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.2 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.21 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.21 rifampicin
rpoC 765577 c.2208G>T synonymous_variant 0.2 rifampicin
rpoC 765871 c.2502T>C synonymous_variant 0.19 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.2 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.2 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.18 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.18 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.19 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.18 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.2 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.2 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.18 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.2 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.21 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.21 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.2 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775814 c.2667C>G synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775817 c.2664T>C synonymous_variant 0.18 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775826 c.2655G>C synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 775829 c.2652C>G synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775834 p.Ala883Ser missense_variant 0.16 clofazimine
bedaquiline
mmpL5 775838 c.2643G>C synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775847 c.2634G>T synonymous_variant 0.18 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775851 p.Ser877Thr missense_variant 0.2 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 775865 c.2616T>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775877 c.2604C>G synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsTG frameshift_variant&missense_variant 0.19 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775892 c.2589C>T synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.18 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.19 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775921 c.2560C>T synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775924 c.2557C>T synonymous_variant 0.19 clofazimine Not assoc w R - Interim
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.22 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.21 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.21 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.22 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.22 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.26 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.33 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.32 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.3 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.31 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.29 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.26 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.25 streptomycin
rpsL 781732 c.174_177delGAGT frameshift_variant 0.25 streptomycin Uncertain significance
rpsL 781739 c.180_181insCGGC frameshift_variant 0.25 streptomycin Uncertain significance
rpsL 781742 c.183C>T synonymous_variant 0.24 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.29 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.29 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.22 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.21 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.2 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.16 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.15 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.15 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.14 streptomycin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1304613 c.1683T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
sigE 1364736 c.324T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.22 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.21 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.22 pyrazinamide
sigE 1364778 c.366G>C synonymous_variant 0.27 pyrazinamide
sigE 1364781 c.369G>C synonymous_variant 0.28 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.25 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.24 pyrazinamide
sigE 1364796 c.384G>A synonymous_variant 0.22 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.22 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.22 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.23 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.23 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.23 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.27 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.27 pyrazinamide
sigE 1364871 c.459C>T synonymous_variant 0.26 pyrazinamide
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>T non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474053 n.396G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631_632delCCinsTCGACT non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474716 n.1059_1063delAAAGCinsCCAAGAGT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475618 n.1961C>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476384 n.2727G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.51 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rpsA 1833694 c.153G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1833811 c.270G>T synonymous_variant 0.16 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.21 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.22 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.21 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.18 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834078 c.537C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.22 pyrazinamide Uncertain significance
rpsA 1834189 c.648G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834345 c.804C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.28 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.28 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.24 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.23 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.21 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 0.94 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
PPE35 2169407 c.1206C>T synonymous_variant 1.0 pyrazinamide
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
eis 2715125 p.Thr70Ala missense_variant 1.0 amikacin Uncertain significance
kanamycin Uncertain significance
folC 2746572 p.Arg343Cys missense_variant 1.0 para-aminosalicylic_acid
Rv2477c 2782927 c.1116A>G synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2680 2995832 c.-273G>A upstream_gene_variant 1.0 capreomycin
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
thyA 3073953 c.519T>C synonymous_variant 0.2 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623372 c.1539G>C synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3623730 p.Ser394Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
fbiB 3641590 p.Gly19Glu missense_variant 1.0 clofazimine
pretomanid
delamanid Uncertain significance
rpoA 3877695 c.813C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.27 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.28 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.32 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.33 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.3 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.3 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.35 rifampicin
rpoA 3877875 c.633T>A synonymous_variant 0.31 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.31 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.31 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.33 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.35 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.31 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 0.3 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.26 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.25 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.24 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.25 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.25 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.22 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.22 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.23 rifampicin
rpoA 3878061 c.447G>A synonymous_variant 0.24 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.25 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.3 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.28 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.29 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.34 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.33 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>A synonymous_variant 0.36 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.37 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 0.39 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.44 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.44 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.45 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.47 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.48 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>A synonymous_variant 0.36 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.33 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.26 rifampicin
rpoA 3878352 c.156C>G synonymous_variant 0.24 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878403 c.105C>T synonymous_variant 0.22 rifampicin
rpoA 3878409 c.99C>G synonymous_variant 0.22 rifampicin
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038623 c.2082A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.25 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.27 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.23 pyrazinamide
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 0.23 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 0.24 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.32 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.32 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.3 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.24 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.27 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.3 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039118 c.1587C>A synonymous_variant 0.29 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.29 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.35 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.28 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.34 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.28 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.28 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.18 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039985 c.720G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040306 c.399G>T synonymous_variant 0.24 pyrazinamide
clpC1 4040309 c.396C>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040324 c.381G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040335 c.370C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040336 c.369G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040390 c.315C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.17 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248118 c.1605T>C synonymous_variant 0.24 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.25 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.24 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.24 ethambutol
embB 4248143 c.1630_1632delTTGinsAC frameshift_variant&missense_variant 0.24 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248158 p.Cys549Ser missense_variant 0.23 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.24 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.25 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.25 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.21 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.21 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.21 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.21 ethambutol Uncertain significance
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R