TB-Profiler result

Run: SRR13423649
Summary

Run ID: SRR13423649

Sample name:

Date: 2024-10-05T03:36:14.845882

Number of reads: 4626113

Percentage reads mapped: 76.28

Median coverage: 101.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 705 c.705A>G synonymous_variant 0.15 isoniazid
dnaA 750 c.750C>A synonymous_variant 0.15 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.15 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.15 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.16 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.14 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>C synonymous_variant 0.16 isoniazid
dnaA 993 c.993A>G synonymous_variant 0.17 isoniazid
dnaA 1005 c.1005G>C synonymous_variant 0.16 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1024 c.1024T>C synonymous_variant 0.2 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.18 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.19 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.19 isoniazid
dnaA 1074 c.1074C>G synonymous_variant 0.19 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.15 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.16 isoniazid
dnaA 1128 c.1128G>C synonymous_variant 0.16 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.15 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.2 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.2 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.18 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.17 isoniazid
dnaA 1179 c.1179G>C synonymous_variant 0.17 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.15 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.15 isoniazid
dnaA 1200 c.1200C>G synonymous_variant 0.15 isoniazid
dnaA 1203 c.1203T>C synonymous_variant 0.15 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.17 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.16 isoniazid
gyrB 6214 c.975G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6277 c.1038C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7213 c.-89G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 7246 c.2007T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7790 c.489G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTTG synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8435 c.1134C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8501 c.1200G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8510 c.1209G>A synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8519 c.1218A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8561 c.1260A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8591 c.1290C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Thr missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8790 c.1489C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8818 p.Ser506Asn missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8894 c.1593C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8900 c.1599G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8982 p.Cys561Ser missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13636 c.-78A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
fgd1 491077 p.Asn99Asp missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491083 p.Val101Ile missense_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491106 c.324T>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491133 c.351A>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575728 c.381C>T synonymous_variant 0.16 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.18 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575764 c.417C>G synonymous_variant 0.27 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.24 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575786 p.Tyr147His missense_variant 0.22 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575824 c.477T>A synonymous_variant 0.23 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.25 isoniazid
ethionamide
mshA 575878 c.531A>G synonymous_variant 0.22 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.19 isoniazid
ethionamide
mshA 575953 c.606G>C synonymous_variant 0.16 isoniazid
ethionamide
mshA 575959 c.612G>A synonymous_variant 0.14 isoniazid
ethionamide
ccsA 620249 p.Ser120Cys missense_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620256 c.366C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620257 p.Ile123Leu missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620269 p.Val127Phe missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620307 c.417C>T synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620319 c.429C>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620349 c.459A>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620607 c.717T>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620613 c.723C>G synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620619 c.729G>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620622 c.732G>C synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620631 c.741T>C synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620643 c.753C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620652 c.762C>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620664 c.774C>T synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620703 c.813G>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 0.94 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.91 ethionamide Uncertain significance
hadA 732298 c.369C>A synonymous_variant 0.16 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.16 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.16 isoniazid
hadA 732319 c.390G>A synonymous_variant 0.15 isoniazid
hadA 732328 c.399C>T synonymous_variant 0.15 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.15 isoniazid Uncertain significance
hadA 732346 c.417T>C synonymous_variant 0.17 isoniazid
hadA 732367 c.438C>G synonymous_variant 0.15 isoniazid
hadA 732391 c.462T>C synonymous_variant 0.16 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.16 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.19 isoniazid
nusG 734407 p.Val52Ile missense_variant 0.14 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.16 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.16 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.19 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.2 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.2 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.2 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.21 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.25 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.17 rifampicin
nusG 734778 c.525G>A synonymous_variant 0.14 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.15 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.15 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.16 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.16 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.26 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.22 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.16 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.15 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.15 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.18 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.15 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.16 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.2 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.19 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.18 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.18 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.2 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.18 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.21 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.21 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.23 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.16 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.15 rifampicin
rpoB 761439 p.Asp545Ser missense_variant 0.15 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.16 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.15 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.15 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.15 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.29 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.32 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.28 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.33 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.41 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.37 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.16 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761765 c.1959T>C synonymous_variant 0.17 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.17 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.16 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.18 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.24 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.24 rifampicin
rpoB 761819 c.2013G>C synonymous_variant 0.27 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.3 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.31 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.28 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.3 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.28 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.28 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.24 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.22 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.22 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.22 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.26 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.24 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.24 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.25 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.26 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.26 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.26 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.24 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.17 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763034 c.-336C>A upstream_gene_variant 0.24 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.28 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.24 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.22 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.23 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.17 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>G synonymous_variant 0.27 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.29 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.19 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.22 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.23 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.26 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.27 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.28 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.26 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.26 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.23 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.22 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.23 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.26 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.22 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.2 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.16 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.15 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.15 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.15 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.16 rifampicin
rpoC 763951 c.582G>T synonymous_variant 0.15 rifampicin
rpoC 763960 c.591T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764040 p.Ser224Asn missense_variant 0.17 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.17 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.18 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.18 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.19 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.22 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.22 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.22 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.25 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.24 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.23 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.23 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764290 c.921C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>G synonymous_variant 0.19 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.18 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.2 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.22 rifampicin
rpoC 764585 c.1216_1218delCTCinsTTG synonymous_variant 0.22 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.22 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>G synonymous_variant 0.25 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.2 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.17 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.27 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.28 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.23 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.29 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.32 rifampicin
rpoC 765649 c.2280C>T synonymous_variant 0.26 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.3 rifampicin
rpoC 765752 p.Asp795Ser missense_variant 0.3 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.28 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.29 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.27 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.17 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.27 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.26 rifampicin
rpoC 766081 c.2712T>C synonymous_variant 0.17 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.17 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.17 rifampicin
rpoC 766258 c.2889T>C synonymous_variant 0.21 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.2 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.2 rifampicin
rpoC 766279 c.2910C>G synonymous_variant 0.23 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.24 rifampicin
rpoC 766300 c.2931C>G synonymous_variant 0.33 rifampicin
rpoC 766312 c.2943T>G synonymous_variant 0.34 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.32 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.29 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.28 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.27 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.28 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.3 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.3 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766393 c.3024C>G synonymous_variant 0.3 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.3 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.29 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.24 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.22 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.21 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.18 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.15 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.15 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.14 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.21 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.24 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.24 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.28 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.29 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.34 rifampicin
rpoC 766651 c.3282T>G synonymous_variant 0.33 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.33 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.33 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.32 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.23 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.25 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.23 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.21 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.2 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.2 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.21 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.28 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.25 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.23 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.22 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.22 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.21 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.23 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.21 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.21 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.22 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.22 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.19 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.19 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.22 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.22 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>G synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.25 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.25 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.26 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.25 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.23 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.23 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.21 streptomycin Uncertain significance
rplC 800591 c.-218C>T upstream_gene_variant 0.19 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.21 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.23 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.23 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.22 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.15 linezolid
rplC 800916 c.108A>C synonymous_variant 0.14 linezolid
rplC 800937 c.129A>G synonymous_variant 0.19 linezolid
rplC 800946 c.138T>C synonymous_variant 0.17 linezolid
rplC 800949 c.141T>C synonymous_variant 0.16 linezolid
rplC 800970 c.162T>C synonymous_variant 0.18 linezolid Not assoc w R - Interim
rplC 800985 c.177A>C synonymous_variant 0.17 linezolid
rplC 801004 p.Leu66Val missense_variant 0.17 linezolid
rplC 801174 c.366T>C synonymous_variant 0.16 linezolid
rplC 801195 c.387G>C synonymous_variant 0.22 linezolid
rplC 801210 c.402T>C synonymous_variant 0.21 linezolid
rplC 801219 c.411C>G synonymous_variant 0.22 linezolid
rplC 801231 c.423C>G synonymous_variant 0.21 linezolid
rplC 801249 c.441T>C synonymous_variant 0.25 linezolid
rplC 801252 c.444G>C synonymous_variant 0.27 linezolid
rplC 801255 c.447C>T synonymous_variant 0.26 linezolid
rplC 801267 c.459A>C synonymous_variant 0.25 linezolid
rplC 801270 c.462T>C synonymous_variant 0.24 linezolid
rplC 801276 c.468G>C synonymous_variant 0.26 linezolid
rplC 801279 c.471G>C synonymous_variant 0.25 linezolid
rplC 801285 c.477G>C synonymous_variant 0.23 linezolid
rplC 801288 c.480G>C synonymous_variant 0.23 linezolid
rplC 801300 c.492C>G synonymous_variant 0.19 linezolid
rplC 801312 c.504G>C synonymous_variant 0.2 linezolid
rplC 801324 c.516T>C synonymous_variant 0.19 linezolid
rplC 801336 c.528C>G synonymous_variant 0.18 linezolid
rplC 801339 c.531T>G synonymous_variant 0.17 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.17 linezolid
rplC 801348 c.540T>G synonymous_variant 0.19 linezolid
rplC 801349 p.Leu181Val missense_variant 0.19 linezolid
rplC 801357 c.549T>C synonymous_variant 0.18 linezolid
rplC 801366 c.558T>C synonymous_variant 0.18 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.18 linezolid
rplC 801387 c.579G>C synonymous_variant 0.19 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303509 c.579G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303521 c.591C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303534 p.Ser202Ala missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303551 c.621G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304484 c.1554C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304493 p.Asp521Glu missense_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304496 c.1566T>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304499 c.1569T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304520 c.1590A>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304530 p.Ser534Ala missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304533 c.1603T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304538 c.1608C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304546 p.Val539Ala missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304604 c.1674C>T synonymous_variant 0.16 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304751 c.1821C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304826 c.1896G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>G synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304931 c.2001C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304955 c.2025G>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304991 c.2061G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Glu missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305006 p.Glu692Asp missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305045 c.2115A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305066 c.2136T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305069 c.2139G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305075 c.2145T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305252 c.2322G>A synonymous_variant 0.15 pretomanid
delamanid
clofazimine
sigE 1364691 c.279T>C synonymous_variant 0.19 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.17 pyrazinamide
sigE 1364715 c.303G>C synonymous_variant 0.18 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.17 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.17 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
sigE 1364739 c.327C>G synonymous_variant 0.16 pyrazinamide
sigE 1364742 c.330A>G synonymous_variant 0.15 pyrazinamide
sigE 1364760 c.348C>G synonymous_variant 0.16 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.16 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.16 pyrazinamide
sigE 1364772 c.360G>T synonymous_variant 0.16 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.2 pyrazinamide
sigE 1364952 c.540A>C synonymous_variant 0.16 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 0.98 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473964 n.307T>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474071 n.414G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474952 n.1296_1300delCATCC non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474962 n.1305T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474967 n.1311_1315delGGGTG non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474995 n.1338T>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475005 n.1348C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475027 n.1370G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475028 n.1371G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475387 n.1730C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid Uncertain significance
rrl 1475603 n.1946G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
inhA 1674342 c.141T>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674603 c.402G>A synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674639 c.438C>G synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674663 c.462G>C synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674669 c.468G>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674690 c.489C>G synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674726 c.525G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674729 c.528G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674750 c.549T>G synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674759 c.558G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674771 c.570C>G synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674780 c.579T>C synonymous_variant 0.15 isoniazid
ethionamide
rpsA 1833604 c.63C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833610 c.69C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833754 c.213G>A synonymous_variant 0.2 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833895 c.354G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833949 c.408T>G synonymous_variant 0.25 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.15 pyrazinamide
rpsA 1834165 c.624A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.16 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834684 c.1143C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834759 c.1218A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834767 p.Lys409Thr missense_variant 0.16 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.15 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.2 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.19 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.21 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.2 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.16 linezolid
tsnR 1853429 c.-177G>T upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064978 c.-250G>T upstream_gene_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
bacA 2065008 c.-280C>G upstream_gene_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.4 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.4 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.33 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.3 isoniazid
kasA 2517980 c.-135C>T upstream_gene_variant 0.29 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.18 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.19 isoniazid
kasA 2518513 c.399C>G synonymous_variant 0.18 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.17 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.17 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.18 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.15 isoniazid
kasA 2518594 c.480C>G synonymous_variant 0.16 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.16 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.18 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.15 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.16 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.15 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.16 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.18 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.18 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.15 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.15 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.16 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.15 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.17 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.16 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.16 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.16 isoniazid
Rv2477c 2782984 c.1059T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.33 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783080 c.963G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>A synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783098 c.945C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783107 c.936G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783371 p.Glu224Gln missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783590 c.453G>A synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783602 c.441G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783617 c.426G>A synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3065625 c.567G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065634 c.558G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065637 c.555A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065649 c.543T>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065658 p.Pro178Leu missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065661 c.531A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065666 c.526T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065667 c.525A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065675 p.Phe173Leu missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065699 p.Ile165Val missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3066118 p.Asn25Ser missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066150 c.42C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066155 p.Ser13Thr missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066168 c.24A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066171 c.21G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066176 p.Pro6Ala missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066177 c.15T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066194 c.-3G>T upstream_gene_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
thyX 3067553 c.393C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067556 p.His130Arg missense_variant 0.21 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067564 p.Leu128Val missense_variant 0.21 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.22 para-aminosalicylic_acid
thyX 3067586 c.360C>A synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067607 c.339C>T synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074047 p.Ala142Val missense_variant 0.21 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.19 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.18 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074064 c.408C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624077 c.834G>C synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624080 c.829_831delAGGinsCGC synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624086 c.825C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624100 c.811T>C synonymous_variant 0.26 rifampicin
bedaquiline
lpqB 3624101 c.810C>G synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624128 p.Gln261Ala missense_variant 0.23 rifampicin
bedaquiline
lpqB 3624133 c.778A>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624166 p.Met249Leu missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624172 p.Val247Ile missense_variant 0.17 rifampicin
bedaquiline
lpqB 3624173 c.738A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624224 c.687T>C synonymous_variant 0.15 rifampicin
bedaquiline
lpqB 3624623 c.288C>G synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624646 c.265T>C synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624649 c.262T>C synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624656 c.255C>T synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624659 c.252C>G synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624680 c.231T>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624686 p.Glu75Gln missense_variant 0.15 rifampicin
bedaquiline
lpqB 3624701 c.210T>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624704 c.207G>C synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624707 c.204G>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624710 c.201G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624728 c.183C>T synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624755 c.154_156delTTAinsCTG synonymous_variant 0.19 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625413 p.Ala401Thr missense_variant 0.18 rifampicin
bedaquiline
lpqB 3625420 c.-510T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625423 c.-513G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625431 c.-521T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.17 rifampicin
bedaquiline
lpqB 3625621 c.-711G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625654 p.Leu320Phe missense_variant 0.16 rifampicin
bedaquiline
lpqB 3625663 c.-753G>T upstream_gene_variant 0.14 rifampicin
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625909 c.-999T>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3625912 c.702G>C synonymous_variant 0.15 rifampicin
bedaquiline
mtrB 3625941 c.673C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3626101 p.Gln171His missense_variant 0.16 rifampicin
bedaquiline
mtrB 3626124 p.Ala164Ser missense_variant 0.14 rifampicin
bedaquiline
mtrB 3626125 c.489C>G synonymous_variant 0.15 rifampicin
bedaquiline
mtrB 3626157 p.Ala153Ser missense_variant 0.16 rifampicin
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626726 c.-113T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGT upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626891 c.-278G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627071 c.-458G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3627400 c.-51A>C upstream_gene_variant 1.0 rifampicin Uncertain significance
bedaquiline
fbiB 3641199 c.-336C>T upstream_gene_variant 0.17 pretomanid
delamanid
clofazimine
fbiA 3641200 p.Ile220Val missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3641217 c.-318C>G upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3641226 c.-309G>C upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3641232 c.-303C>G upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3641235 c.-300G>C upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3641239 c.-296T>C upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3641244 c.-291G>C upstream_gene_variant 0.21 pretomanid
delamanid
clofazimine
fbiA 3641245 p.Glu235Ser missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3641250 c.-285A>G upstream_gene_variant 0.22 pretomanid
delamanid
clofazimine
fbiB 3641256 c.-279A>G upstream_gene_variant 0.23 pretomanid
delamanid
clofazimine
fbiA 3641260 p.Ile240Val missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiA 3641286 c.744C>T synonymous_variant 0.25 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiA 3641288 p.Glu249Gly missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiB 3641292 c.-243G>A upstream_gene_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3641295 c.-240G>C upstream_gene_variant 0.23 pretomanid
delamanid
clofazimine
fbiA 3641314 p.Thr258Ala missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiB 3641322 c.-213T>G upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3641328 c.-207T>G upstream_gene_variant 0.18 pretomanid
delamanid
clofazimine
fbiB 3642620 c.1086T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiB 3642633 p.Asp367Arg missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiB 3642668 c.1134A>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
rpoA 3877587 c.921A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.23 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.2 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.18 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.2 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.15 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>T synonymous_variant 0.15 rifampicin
rpoA 3877803 c.705G>C synonymous_variant 0.16 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877899 p.Ser203Thr missense_variant 0.18 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.18 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.22 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.22 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.22 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.23 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>C synonymous_variant 0.21 rifampicin
rpoA 3878046 c.462T>A synonymous_variant 0.23 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.24 rifampicin
rpoA 3878067 c.441C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878070 c.438T>C synonymous_variant 0.2 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.22 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878103 c.405A>G synonymous_variant 0.26 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.29 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.28 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.26 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.22 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.24 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.2 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.15 rifampicin
rpoA 3878284 p.Glu75Ala missense_variant 0.16 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.15 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.15 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.15 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.27 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.26 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.22 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.28 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.26 rifampicin
rpoA 3878950 c.-443C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.2 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.26 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.32 rifampicin
rpoA 3879043 c.-536C>G upstream_gene_variant 0.28 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879079 c.-572A>C upstream_gene_variant 0.28 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.31 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879115 c.-608G>A upstream_gene_variant 0.27 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.26 rifampicin
clpC1 4038299 c.2406C>A synonymous_variant 0.15 pyrazinamide
clpC1 4038314 c.2391T>A synonymous_variant 0.14 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.18 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.17 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.17 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038698 c.2007C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038884 c.1821C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039043 c.1662G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039166 c.1539G>A synonymous_variant 0.18 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.18 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039582 p.Thr375Ser missense_variant 0.26 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.19 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040108 c.597G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040180 c.525C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.2 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040234 c.471C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040240 c.465C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.2 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040335 c.370C>T synonymous_variant 0.28 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.25 pyrazinamide
clpC1 4040372 c.333C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.15 pyrazinamide
panD 4044995 c.-714A>G upstream_gene_variant 0.2 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.18 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.16 pyrazinamide
glpK 4138451 c.1305T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138574 c.1182G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138640 c.1116C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138696 p.Pro354Ala missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.13 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4239020 c.-843G>C upstream_gene_variant 0.15 ethambutol
embC 4239023 c.-840C>G upstream_gene_variant 0.15 ethambutol
embC 4239027 c.-836A>G upstream_gene_variant 0.17 ethambutol
embC 4239032 c.-831T>C upstream_gene_variant 0.17 ethambutol Uncertain significance
embC 4239057 c.-806A>G upstream_gene_variant 0.21 ethambutol
embC 4239068 c.-795A>G upstream_gene_variant 0.21 ethambutol
embC 4239071 c.-792A>G upstream_gene_variant 0.21 ethambutol Uncertain significance
embC 4239076 c.-787C>T upstream_gene_variant 0.22 ethambutol
embC 4239079 c.-784_-783delCAinsGG upstream_gene_variant 0.21 ethambutol
embC 4239083 c.-780C>G upstream_gene_variant 0.24 ethambutol
embC 4239116 c.-747C>T upstream_gene_variant 0.21 ethambutol Uncertain significance
embC 4239125 c.-738C>G upstream_gene_variant 0.17 ethambutol
embC 4239131 c.-732G>A upstream_gene_variant 0.17 ethambutol
embC 4239141 c.-722G>A upstream_gene_variant 0.18 ethambutol Uncertain significance
embC 4239146 c.-717A>G upstream_gene_variant 0.16 ethambutol Uncertain significance
embC 4239147 c.-716T>C upstream_gene_variant 0.16 ethambutol
embC 4239161 c.-702A>C upstream_gene_variant 0.15 ethambutol
embC 4240543 c.681G>C synonymous_variant 0.16 ethambutol
embC 4240545 p.Pro228Gln missense_variant 0.17 ethambutol
embC 4240558 c.696C>G synonymous_variant 0.19 ethambutol
embC 4240561 c.699C>G synonymous_variant 0.18 ethambutol
embC 4240576 c.714A>G synonymous_variant 0.2 ethambutol
embC 4240578 p.Ala239Val missense_variant 0.21 ethambutol
embC 4240587 p.Gly242Ala missense_variant 0.26 ethambutol
embC 4240598 p.Val246Ile missense_variant 0.23 ethambutol
embC 4240610 p.Ile250Leu missense_variant 0.24 ethambutol
embC 4240615 c.753G>C synonymous_variant 0.24 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248001 c.1488C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.19 ethambutol
embB 4248019 c.1506G>C synonymous_variant 0.19 ethambutol
embB 4248025 c.1512A>G synonymous_variant 0.2 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.16 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.16 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.16 ethambutol Uncertain significance
embB 4248044 p.Lys511Glu missense_variant 0.16 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.17 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.19 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.22 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.23 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.2 ethambutol
embB 4248124 c.1611G>C synonymous_variant 0.2 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.19 ethambutol
embB 4248146 p.Ile545Val missense_variant 0.19 ethambutol
embB 4248154 c.1641G>C synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248163 c.1650G>C synonymous_variant 0.16 ethambutol
embB 4248169 c.1656C>G synonymous_variant 0.16 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.16 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.17 ethambutol Uncertain significance
embB 4248214 c.1701C>G synonymous_variant 0.15 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
ethA 4326676 p.Ser266Arg missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R