TB-Profiler result

Run: ERR9787256
Summary

Run ID: ERR9787256

Sample name:

Date: 2024-04-16T10:20:25.731923

Number of reads: 1360042

Percentage reads mapped: 68.06

Median coverage: 55.0

Strain: lineage6.1.3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6.1.3 West-Africa 2 RD702 0.99
lineage6 West-Africa 2 RD702 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embC p.Ala307Thr Uncertain significance Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embC 4240781 p.Ala307Thr missense_variant 0.97 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7412 c.111C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7613 c.312G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7709 c.408G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8315 c.1014G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>T synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8393 p.Tyr364* stop_gained 0.13 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8414 c.1113C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8433 p.Thr378Arg missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8456 c.1155C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8493 p.Leu398Phe missense_variant 0.69 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8504 c.1203G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8633 c.1332C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8806 p.Asp502Gly missense_variant 0.97 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9267 p.Asn656Gly missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9324 c.2023_2025delTCGinsAGC synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9329 c.2028C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCC frameshift_variant&missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.18 levofloxacin
moxifloxacin
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 491668 p.Lys296Glu missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.14 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.15 ethionamide
isoniazid Uncertain significance
mshA 575749 c.402C>A synonymous_variant 0.18 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.17 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.16 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.16 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.14 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.15 ethionamide
isoniazid
mshA 575800 c.453G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.16 ethionamide
isoniazid Not assoc w R - Interim
mshA 575821 c.474G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.18 ethionamide
isoniazid
Rv0565c 656432 p.Gly347Ser missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.98 ethionamide
rpoB 760181 c.375T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.33 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.35 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.33 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.34 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.29 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.33 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.3 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.3 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.28 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.17 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.17 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.16 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.16 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.15 rifampicin
rpoB 760585 p.Asn260Ser missense_variant 0.2 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.19 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.19 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.19 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.18 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760805 c.999G>C synonymous_variant 0.18 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.22 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.24 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760855 p.Thr350Ile missense_variant 0.73 rifampicin Uncertain significance
rpoB 760859 c.1053T>C synonymous_variant 0.25 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.22 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.2 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.2 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.2 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.25 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.24 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.24 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760958 c.1152G>C synonymous_variant 0.24 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.24 rifampicin Uncertain significance
rpoB 760969 p.Ser388Phe missense_variant 0.78 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.16 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.17 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.19 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.2 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.2 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.16 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.23 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.23 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.19 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.24 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.27 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.29 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.3 rifampicin
rpoB 761708 c.1902C>T synonymous_variant 0.29 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.28 rifampicin
rpoB 761718 c.1912_1913delGCinsT frameshift_variant&missense_variant 0.24 rifampicin
rpoB 761722 p.Glu639Gly missense_variant 0.26 rifampicin Uncertain significance
rpoB 761727 p.Ser641Gly missense_variant 0.3 rifampicin
rpoB 761732 c.1926_1927delCGinsGCA frameshift_variant&missense_variant 0.26 rifampicin
rpoB 761736 p.Ile644Val missense_variant 0.27 rifampicin Uncertain significance
rpoB 761747 c.1941G>C synonymous_variant 0.27 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.17 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.16 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.16 rifampicin
rpoB 761785 p.Thr660Ser missense_variant 0.15 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.15 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.26 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.3 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.31 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.29 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.28 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>T synonymous_variant 0.27 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.3 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.26 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.31 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.3 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.34 rifampicin
rpoB 762350 c.2544C>T synonymous_variant 0.32 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.31 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.31 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.31 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.32 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.33 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.32 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.34 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.28 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.28 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.21 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.2 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.26 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.67 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.23 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.14 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>T upstream_gene_variant 0.14 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.17 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.18 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.15 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCT frameshift_variant&missense_variant 0.16 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.16 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.15 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.21 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.22 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.25 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.23 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.21 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.22 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.23 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.19 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.17 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.15 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.15 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.16 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.16 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.14 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.15 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.15 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.15 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.16 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.15 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764195 c.826_828delTCGinsAGC synonymous_variant 0.15 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.15 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.16 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.16 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.16 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.16 rifampicin
rpoC 764227 c.858G>T synonymous_variant 0.15 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.17 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.17 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.17 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.19 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.2 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.14 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.15 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.14 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.21 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.2 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.2 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.21 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764686 c.1317C>T synonymous_variant 0.25 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.27 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 0.25 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.18 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.17 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.21 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.21 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.23 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.22 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.22 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.22 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.2 rifampicin
rpoC 766231 c.2862T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.17 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.17 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.17 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.18 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775838 c.2643G>C synonymous_variant 0.14 clofazimine
bedaquiline
mmpL5 775851 p.Ser877Thr missense_variant 0.15 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 775865 c.2616T>C synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 775877 c.2604C>G synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 775892 c.2589C>T synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.16 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.15 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.15 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.18 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.19 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.19 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.2 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.16 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.18 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.19 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.22 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.21 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.21 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.2 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 800232 c.-577G>T upstream_gene_variant 1.0 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.16 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.16 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.15 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.15 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.16 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.16 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.15 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.15 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.15 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
sigE 1364865 c.453G>C synonymous_variant 0.16 pyrazinamide
sigE 1364868 c.456T>C synonymous_variant 0.16 pyrazinamide
sigE 1364887 c.475T>C synonymous_variant 0.15 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.15 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.15 pyrazinamide
sigE 1364931 c.519C>T synonymous_variant 0.15 pyrazinamide
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1461251 c.207G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>A non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472912 n.1067C>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473633 n.-25C>T upstream_gene_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154_155insT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473814 n.158delT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473829 n.172G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631_632delCCinsTCGACT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474426 n.769T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475618 n.1961C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
inhA 1673799 c.-403T>C upstream_gene_variant 0.14 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.15 ethionamide
isoniazid
inhA 1673808 c.-394A>C upstream_gene_variant 0.15 ethionamide
isoniazid
fabG1 1673829 p.Asn130Lys missense_variant 0.17 ethionamide
isoniazid
fabG1 1673830 p.Lys131Arg missense_variant 0.17 ethionamide
isoniazid
inhA 1673838 c.-364T>C upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673841 c.-361A>G upstream_gene_variant 0.17 ethionamide
isoniazid
fabG1 1673844 p.Met135Ile missense_variant 0.16 ethionamide
isoniazid
inhA 1673847 c.-355A>C upstream_gene_variant 0.15 ethionamide
isoniazid
inhA 1673853 c.-349A>C upstream_gene_variant 0.15 ethionamide
isoniazid
inhA 1673856 c.-346T>C upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1673865 c.-337C>G upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1673870 p.Ser144Met missense_variant 0.23 ethionamide
isoniazid
inhA 1673877 c.-325C>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.18 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.18 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.18 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673931 c.-271C>G upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1674434 p.Val78Ala missense_variant 1.0 ethionamide Uncertain significance
isoniazid Not assoc w R
rpsA 1833829 c.288A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.19 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.21 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.2 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.2 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.18 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.16 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834168 c.627C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834169 p.Thr210Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.2 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.23 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.36 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.34 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.34 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.28 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.2 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.18 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 0.98 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063121 c.1608A>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 0.97 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 0.98 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.15 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.14 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.14 isoniazid
kasA 2518789 c.675G>T synonymous_variant 0.15 isoniazid
kasA 2518813 c.699C>T synonymous_variant 0.18 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.18 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.17 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.15 isoniazid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
ald 3087412 p.Asp198Val missense_variant 1.0 cycloserine
Rv3236c 3612143 p.Arg325His missense_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626184 p.Ala144Thr missense_variant 1.0 bedaquiline
rifampicin
mtrB 3627023 c.-410C>T upstream_gene_variant 0.87 bedaquiline
rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.22 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.22 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.24 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.24 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.76 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.15 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.18 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.19 rifampicin
rpoA 3877875 c.633T>A synonymous_variant 0.18 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.18 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.17 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.21 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.2 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.15 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 0.17 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.16 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.16 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.14 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878050 p.Arg153Lys missense_variant 0.14 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.16 rifampicin
rpoA 3878061 c.447G>A synonymous_variant 0.19 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.23 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.25 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.25 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.24 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.25 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.26 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.25 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 0.26 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.22 rifampicin
rpoA 3878247 c.261G>A synonymous_variant 0.21 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.19 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.17 rifampicin
clpC1 4038419 c.2286T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.15 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.17 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.17 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 0.16 pyrazinamide
clpC1 4038536 c.2169C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038541 c.2164C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038551 c.2154C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038563 c.2142C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038584 c.2121G>A synonymous_variant 0.16 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.15 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.15 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.14 pyrazinamide
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 0.14 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 0.16 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.21 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.29 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039118 c.1587C>A synonymous_variant 0.27 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039178 c.1527G>T synonymous_variant 0.19 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.17 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.15 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.14 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039337 c.1368A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.21 pyrazinamide
clpC1 4039457 c.1248C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.27 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.27 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 0.19 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.18 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.18 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039985 c.720G>A synonymous_variant 0.18 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040092 p.Ser205Thr missense_variant 0.14 pyrazinamide
clpC1 4040126 c.579C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040237 c.468C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040309 c.396C>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139183 c.572dupG frameshift_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241843 p.Leu661Ile missense_variant 0.95 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244379 p.Pro383Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246445 c.-69C>T upstream_gene_variant 1.0 ethambutol
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248088 c.1575C>T synonymous_variant 0.16 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.17 ethambutol
embB 4248112 c.1599C>G synonymous_variant 0.17 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.16 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.14 ethambutol
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269522 c.312C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326465 p.Ile337Val missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338602 c.-81A>C upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4408034 p.Glu57Lys missense_variant 1.0 streptomycin Uncertain significance