TB-Profiler result

Run: SRR1184024
Summary

Run ID: SRR1184024

Sample name:

Date: 2024-04-15T14:42:23.667175

Number of reads: 2846002

Percentage reads mapped: 61.84

Median coverage: 66.0

Strain: lineage2.2.1.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.97
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
lineage2.2.1.1 East-Asian (Beijing) RD105;RD207;RD181;RD150 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.1945_1947delATTinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.18 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1304875 c.1945_1947delATTinsGG frameshift_variant&missense_variant 0.24 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247448 p.His312Arg missense_variant 0.4 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1035 c.1035A>G synonymous_variant 0.15 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.22 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.23 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.26 isoniazid
dnaA 1107 c.1107C>T synonymous_variant 0.2 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.25 isoniazid
dnaA 1122 c.1122C>A synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1125 c.1125G>C synonymous_variant 0.21 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.18 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.15 isoniazid
dnaA 1199 p.Arg400His missense_variant 0.88 isoniazid Uncertain significance
dnaA 1254 c.1254T>C synonymous_variant 0.15 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.16 isoniazid
dnaA 1317 c.1317A>C synonymous_variant 0.17 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.16 isoniazid
gyrB 5284 c.45G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 5287 c.48T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 5293 c.54C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 5302 c.63A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 5305 c.66G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 5308 c.69G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6145 c.906C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6259 p.Asp340Glu missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6331 c.-971A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6361 c.-941G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6835 c.-467C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6847 c.-455C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6850 c.1611C>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6856 c.1617T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6866 c.-436C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7060 c.1821T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7625 c.324G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7766 c.465C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7769 c.468C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7793 c.492G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7838 c.537C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8096 c.795T>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8207 c.906T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8252 c.951G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8321 c.1020C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.18 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8510 c.1209G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8561 c.1260A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8655 p.Ile452Val missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8810 c.1509A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8855 c.1554C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8858 c.1557T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8876 c.1575C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8930 c.1629C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>A synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8957 c.1656C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9101 c.1800A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.17 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9185 c.1884C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9192 c.1891C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9203 c.1902G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9452 c.2151G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9476 c.2175G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9479 c.2178G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9485 c.2184A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9491 c.2190C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9494 c.2193T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9497 c.2196G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9503 c.2202T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
fgd1 490830 c.48A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491112 c.330G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575561 p.Met72Val missense_variant 0.18 ethionamide
isoniazid
mshA 575590 c.243T>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.26 ethionamide
isoniazid
mshA 575851 c.504C>T synonymous_variant 0.22 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575878 c.531A>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.34 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.73 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.18 ethionamide
isoniazid
ccsA 620415 c.525T>C synonymous_variant 0.2 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657647 c.-179_-177delGTCinsAT upstream_gene_variant 0.16 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.16 ethionamide
Rv0565c 657690 c.-220C>A upstream_gene_variant 0.15 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.16 ethionamide
hadA 731753 c.-177A>G upstream_gene_variant 0.18 isoniazid
hadA 731768 c.-162G>A upstream_gene_variant 0.16 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.35 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.23 isoniazid
hadA 731795 c.-135C>T upstream_gene_variant 0.17 isoniazid
hadA 731798 c.-132C>G upstream_gene_variant 0.22 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.18 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.18 isoniazid
hadA 732361 c.432C>T synonymous_variant 0.24 isoniazid
hadA 732376 c.447T>C synonymous_variant 0.2 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.17 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.28 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.27 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.18 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.16 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.17 rifampicin
nusG 734457 c.204C>T synonymous_variant 0.17 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.17 rifampicin
nusG 734505 c.252G>A synonymous_variant 0.16 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.18 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.32 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.26 rifampicin
rpoB 759635 c.-172C>T upstream_gene_variant 0.16 rifampicin
rpoB 759644 c.-163T>A upstream_gene_variant 0.18 rifampicin
rpoB 759647 c.-160T>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoB 759661 c.-146G>C upstream_gene_variant 0.16 rifampicin
rpoB 759670 c.-137C>T upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoB 759671 c.-136G>T upstream_gene_variant 0.18 rifampicin
rpoB 759675 c.-132T>C upstream_gene_variant 0.17 rifampicin
rpoB 759676 c.-131A>G upstream_gene_variant 0.18 rifampicin
rpoB 759701 c.-106A>T upstream_gene_variant 0.16 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.2 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760145 c.339C>G synonymous_variant 0.16 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.24 rifampicin
rpoB 760307 c.501T>C synonymous_variant 0.35 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.18 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.28 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760356 c.550_552delACCinsTG frameshift_variant&missense_variant 0.17 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.16 rifampicin
rpoB 760381 p.Thr192Met missense_variant 0.15 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.23 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.18 rifampicin Uncertain significance
rpoB 760533 p.Val243His missense_variant 0.16 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.17 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.26 rifampicin
rpoB 760598 c.792C>T synonymous_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.23 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.23 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.22 rifampicin
rpoB 760754 c.948G>C synonymous_variant 0.22 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.22 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.22 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.22 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.23 rifampicin
rpoB 760796 c.990A>G synonymous_variant 0.2 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.24 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.22 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.18 rifampicin
rpoB 760859 c.1053T>G synonymous_variant 0.15 rifampicin
rpoB 760868 c.1062C>G synonymous_variant 0.18 rifampicin
rpoB 760877 c.1071G>T synonymous_variant 0.15 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.19 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.21 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.27 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.29 rifampicin
rpoB 761168 c.1362C>G synonymous_variant 0.23 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.19 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.16 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.21 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.35 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.32 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.32 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.35 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.3 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.28 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.24 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.19 rifampicin
rpoB 761452 p.Val549Asp missense_variant 0.15 rifampicin
rpoB 761465 c.1659G>T synonymous_variant 0.19 rifampicin
rpoB 761471 c.1665C>T synonymous_variant 0.18 rifampicin
rpoB 761477 c.1671C>T synonymous_variant 0.15 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.23 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.25 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.18 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.17 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.18 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761540 c.1734C>T synonymous_variant 0.21 rifampicin
rpoB 761561 c.1755C>G synonymous_variant 0.36 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761582 c.1776G>A synonymous_variant 0.33 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.4 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.3 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.19 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.18 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.18 rifampicin
rpoB 761735 c.1929C>G synonymous_variant 0.15 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.18 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.18 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>A synonymous_variant 0.22 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.17 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.25 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.29 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.16 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.25 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.27 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.27 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.17 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.17 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.2 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.21 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762050 c.2244G>A synonymous_variant 0.23 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.4 rifampicin Uncertain significance
rpoB 762138 c.2332C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.27 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.25 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.25 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.31 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.29 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.21 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.22 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.18 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.19 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.18 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.21 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.2 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.21 rifampicin
rpoC 762401 c.-969G>T upstream_gene_variant 0.18 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.22 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.22 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762507 c.2701_2703delCTTinsAG frameshift_variant&missense_variant 0.25 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.28 rifampicin Uncertain significance
rpoC 762524 c.-846G>C upstream_gene_variant 0.2 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.21 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.21 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.21 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.19 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762812 c.3006C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762827 c.-543G>T upstream_gene_variant 0.18 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762920 c.-450C>G upstream_gene_variant 0.32 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.33 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 0.23 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>A upstream_gene_variant 0.24 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.16 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.25 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.31 rifampicin
rpoC 763193 c.-177C>T upstream_gene_variant 0.25 rifampicin
rpoC 763199 c.-171G>T upstream_gene_variant 0.21 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.2 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.21 rifampicin
rpoC 763211 c.-159C>T upstream_gene_variant 0.2 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.32 rifampicin
rpoC 763423 c.54G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.24 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>A synonymous_variant 0.24 rifampicin
rpoC 763573 c.204G>T synonymous_variant 0.27 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>A synonymous_variant 0.29 rifampicin
rpoC 763618 c.249C>T synonymous_variant 0.32 rifampicin
rpoC 763621 c.252C>G synonymous_variant 0.29 rifampicin
rpoC 763636 c.267T>G synonymous_variant 0.39 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763681 c.312C>A synonymous_variant 0.28 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.26 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.38 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.23 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.39 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.33 rifampicin
rpoC 763768 c.399C>T synonymous_variant 0.22 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.28 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.2 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.23 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.23 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.26 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.26 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.23 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.24 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.29 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.31 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.27 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.29 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.3 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.28 rifampicin
rpoC 763969 c.600C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>G synonymous_variant 0.25 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.21 rifampicin
rpoC 764195 p.Ser276Ile missense_variant 0.21 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.21 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764218 c.849C>T synonymous_variant 0.28 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>A synonymous_variant 0.33 rifampicin
rpoC 764260 c.891G>A synonymous_variant 0.3 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.32 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.42 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.37 rifampicin
rpoC 764339 c.970C>T synonymous_variant 0.33 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.2 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.22 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.23 rifampicin
rpoC 764452 c.1083T>G synonymous_variant 0.22 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.2 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.21 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.2 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.26 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.32 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.29 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764782 c.1413C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.21 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.27 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.25 rifampicin
rpoC 764857 c.1488G>T synonymous_variant 0.2 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.21 rifampicin
rpoC 764887 c.1518G>A synonymous_variant 0.19 rifampicin
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.31 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.19 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.2 rifampicin
rpoC 764902 c.1533C>T synonymous_variant 0.25 rifampicin
rpoC 764908 c.1539G>A synonymous_variant 0.23 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.19 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765334 c.1965C>T synonymous_variant 0.16 rifampicin
rpoC 765343 c.1974G>A synonymous_variant 0.17 rifampicin
rpoC 765352 c.1983G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765367 c.1998C>G synonymous_variant 0.2 rifampicin
rpoC 765370 c.2001G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.25 rifampicin Uncertain significance
rpoC 765404 c.2035C>T synonymous_variant 0.27 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.32 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.27 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>T synonymous_variant 0.28 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>A synonymous_variant 0.36 rifampicin
rpoC 765529 c.2160C>T synonymous_variant 0.32 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.33 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.36 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.3 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.31 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.19 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.26 rifampicin
rpoC 765592 c.2223C>T synonymous_variant 0.16 rifampicin
rpoC 765622 p.Glu751Asp missense_variant 0.16 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765685 c.2316G>A synonymous_variant 0.22 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765787 c.2418C>T synonymous_variant 0.23 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.24 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.25 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.29 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.26 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765907 c.2538G>A synonymous_variant 0.16 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.28 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.16 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766082 p.Ala905Gln missense_variant 0.16 rifampicin
rpoC 766096 c.2727G>T synonymous_variant 0.18 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.19 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.19 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.15 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.19 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.19 rifampicin
rpoC 766288 c.2919C>T synonymous_variant 0.17 rifampicin
rpoC 766294 c.2925C>T synonymous_variant 0.17 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.24 rifampicin
rpoC 766333 c.2964G>C synonymous_variant 0.19 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.17 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.15 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.25 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.27 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.18 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.2 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.33 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.24 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.38 rifampicin
rpoC 766492 c.3123T>A synonymous_variant 0.28 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.26 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.27 rifampicin
rpoC 766540 c.3171C>T synonymous_variant 0.24 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.26 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.26 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.26 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.31 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.36 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.33 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.35 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.38 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.22 rifampicin
rpoC 766666 c.3297C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.37 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.42 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.26 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.44 rifampicin
rpoC 766792 c.3423C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766795 c.3426C>T synonymous_variant 0.18 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.23 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.24 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.2 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.2 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.2 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.21 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.21 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.29 rifampicin
rpoC 767044 c.3675G>A synonymous_variant 0.24 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.37 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.27 rifampicin
rpoC 767152 c.3783T>G synonymous_variant 0.24 rifampicin
rpoC 767158 c.3789T>A synonymous_variant 0.24 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.3 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 0.3 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.32 rifampicin
rpoC 767209 c.3840T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.17 rifampicin
rpoC 767275 c.3906T>A synonymous_variant 0.16 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 0.98 clofazimine
bedaquiline
rpsL 781301 c.-259C>T upstream_gene_variant 0.97 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 0.98 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.14 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.2 streptomycin
rpsL 781622 c.63C>G synonymous_variant 0.17 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.26 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.26 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.26 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.21 streptomycin
rpsL 781703 c.144G>A synonymous_variant 0.17 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.25 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.26 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.28 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.21 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.19 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.16 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.16 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.3 streptomycin
rpsL 781820 c.261G>T synonymous_variant 0.19 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.28 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.33 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.33 streptomycin
rpsL 781886 c.327C>T synonymous_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.32 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.34 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.24 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.19 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.19 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.2 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.2 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.22 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.23 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.18 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.24 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.21 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.28 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.18 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.14 linezolid
rplC 801312 c.504G>C synonymous_variant 0.17 linezolid
rplC 801339 c.531T>G synonymous_variant 0.17 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.17 linezolid
rplC 801348 c.540T>G synonymous_variant 0.17 linezolid
rplC 801357 c.549T>C synonymous_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302818 c.-113G>C upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303545 c.615A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304823 c.1893C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304896 c.1966C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304915 p.Asp662Gly missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304988 c.2058G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461131 c.87T>C synonymous_variant 0.17 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.16 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473417 n.-241C>T upstream_gene_variant 0.17 capreomycin
linezolid
rrl 1473421 n.-237G>A upstream_gene_variant 0.16 capreomycin
linezolid
rrl 1473437 n.-221T>C upstream_gene_variant 0.19 capreomycin
linezolid
rrl 1473648 n.-9_-7delTTG upstream_gene_variant 0.17 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474156 n.499G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474163 n.506C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474292 n.635_654delTTCCTCTCCGGAGGAGGGTGinsGTGGA non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475402 n.1746T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid Uncertain significance
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475605 n.1948A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475617 n.1960C>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475625 n.1968G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475637 n.1980T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475999 n.2342G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476032 n.2375C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476047 n.2390G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476077 n.2420T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476104 n.2448delG non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476595 n.2938C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476602 n.2945G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
inhA 1673916 c.-286A>T upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673970 c.-232C>G upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1673976 c.-226T>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673982 c.-220G>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.16 ethionamide
isoniazid
rpsA 1833532 c.-10A>C upstream_gene_variant 0.18 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.34 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.38 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.24 pyrazinamide
rpsA 1833610 c.69C>A synonymous_variant 0.16 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833782 p.Ser81Thr missense_variant 0.2 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.21 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833934 c.393C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833949 c.408T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.29 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834154 p.Asn205His missense_variant 0.17 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834279 c.738C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834306 c.765T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.19 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834615 c.1074C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834624 c.1083G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.22 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.25 pyrazinamide
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.17 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.15 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.17 linezolid
tsnR 1853485 c.-121G>C upstream_gene_variant 0.16 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064269 c.460A>C synonymous_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064271 p.Trp153Ser missense_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
ndh 2101990 c.1053G>C synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101999 c.1044G>A synonymous_variant 0.21 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102020 c.1023A>G synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>T synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102035 c.1008C>G synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102263 c.780G>A synonymous_variant 0.18 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155680 c.432G>C synonymous_variant 0.19 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.21 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.23 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223014 p.Tyr51Asn missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.3 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.2 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.22 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.23 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.15 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.21 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.17 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.19 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.2 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.23 isoniazid
kasA 2518894 c.780G>A synonymous_variant 0.17 isoniazid
kasA 2519161 c.1047G>A synonymous_variant 0.15 isoniazid
eis 2714846 p.Val163Ile missense_variant 1.0 amikacin Not assoc w R
kanamycin Not assoc w R
ahpC 2726348 c.156T>C synonymous_variant 0.17 isoniazid
ahpC 2726354 c.162G>C synonymous_variant 0.16 isoniazid
folC 2746657 c.942T>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746663 c.936T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2746990 p.Asp203Glu missense_variant 0.16 para-aminosalicylic_acid
Rv2477c 2783194 c.849A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783427 p.Pro206Ala missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.22 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783449 c.594C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783566 c.477C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783791 c.252C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783836 c.207C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783842 c.201C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 c.87T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784454 c.-412G>A upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784492 c.-450C>G upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065947 p.Gly82Ala missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066071 c.121T>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066084 c.108C>T synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066456 c.-265A>G upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066465 c.-276_-274delGGGinsAC upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066468 c.-277C>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066471 c.-280A>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066474 c.-283G>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066480 c.-291_-289delGCCinsTT upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066504 c.-313C>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066513 c.-322C>G upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067373 c.573C>G synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073905 c.567C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073932 c.540C>T synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073983 c.489C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074046 c.426G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.24 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.21 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074133 c.339C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074163 c.309T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074184 c.288A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074196 c.276G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074199 c.273G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.25 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074217 c.255T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074220 c.252A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074244 c.228A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074256 c.216G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074268 c.204T>C synonymous_variant 0.19 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3623468 c.1443T>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623471 c.1440C>T synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623489 c.1422C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623492 c.1419T>C synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625630 c.-720C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625663 c.-753G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625693 c.-783G>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625708 c.906C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.24 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625828 c.-918G>A upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3626804 c.546A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626819 c.-206G>A upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627190 c.160T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627203 c.-590C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627287 c.-674C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
fbiA 3640282 c.-261C>G upstream_gene_variant 0.17 clofazimine
pretomanid
delamanid
fbiA 3640298 c.-245A>G upstream_gene_variant 0.19 clofazimine
pretomanid
delamanid
fbiA 3640318 c.-225A>T upstream_gene_variant 0.18 clofazimine
pretomanid
delamanid
rpoA 3877557 c.951C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.25 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.19 rifampicin
rpoA 3877677 c.829_831delGCGinsAC frameshift_variant&missense_variant 0.16 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.21 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.2 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.16 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.15 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.16 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.16 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>A synonymous_variant 0.16 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.18 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.17 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.18 rifampicin
rpoA 3878043 c.465G>C synonymous_variant 0.17 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.16 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.22 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.26 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.26 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.17 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.27 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878295 c.213A>G synonymous_variant 0.23 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878355 c.153C>G synonymous_variant 0.2 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.25 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878406 c.102G>T synonymous_variant 0.3 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.2 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.22 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.22 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.21 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.16 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.17 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878728 c.-221G>A upstream_gene_variant 0.19 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.2 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.24 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.16 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.29 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878837 c.-331_-330delAAinsGG upstream_gene_variant 0.2 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.37 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.31 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3879006 c.-499A>C upstream_gene_variant 0.18 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.19 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.25 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.28 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879190 c.-683C>T upstream_gene_variant 0.18 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.2 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.17 rifampicin
clpC1 4038278 c.2427T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038289 p.Asn806Asp missense_variant 0.24 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038323 c.2382C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038329 p.Glu792Asp missense_variant 0.27 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.16 pyrazinamide
clpC1 4038486 p.Gly740Thr missense_variant 0.18 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.23 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.36 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.4 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.36 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.22 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.24 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038692 c.2013C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038698 c.2007C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038815 c.1890G>A synonymous_variant 0.28 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.22 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.17 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.33 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.32 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039021 c.1684C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039140 p.Glu522Val missense_variant 0.19 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.3 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039238 c.1467C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039268 c.1437C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039274 c.1431G>T synonymous_variant 0.22 pyrazinamide
clpC1 4039277 c.1428C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>T synonymous_variant 0.16 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.17 pyrazinamide
clpC1 4039355 c.1350G>T synonymous_variant 0.18 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.21 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039472 c.1233G>T synonymous_variant 0.2 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.18 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039727 c.978C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>T synonymous_variant 0.31 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.28 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039997 c.708C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040021 c.684A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040030 c.675C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040138 c.567G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040243 c.462C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040288 c.417C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040321 c.384C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.17 pyrazinamide
embC 4240741 c.879C>T synonymous_variant 0.22 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.29 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.21 ethambutol
embC 4240811 c.949_951delTTCinsCA frameshift_variant&missense_variant 0.2 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.21 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.2 ethambutol
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244885 c.1653A>G synonymous_variant 0.36 ethambutol
embA 4244886 c.1654C>T synonymous_variant 0.36 ethambutol
embA 4244897 c.1665T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embA 4244900 c.1668G>C synonymous_variant 0.33 ethambutol
embA 4244904 p.Val558Leu missense_variant 0.33 ethambutol Uncertain significance
embA 4244909 c.1677C>G synonymous_variant 0.31 ethambutol
embA 4244916 c.1684C>T synonymous_variant 0.28 ethambutol
embA 4244921 c.1689C>G synonymous_variant 0.28 ethambutol
embA 4244933 c.1701A>G synonymous_variant 0.21 ethambutol
embA 4244936 c.1704C>G synonymous_variant 0.2 ethambutol
embA 4244939 c.1707G>A synonymous_variant 0.2 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.22 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.19 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.16 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.15 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.16 ethambutol
embB 4246316 c.-198T>C upstream_gene_variant 0.17 ethambutol
embB 4246346 c.-168C>G upstream_gene_variant 0.24 ethambutol
embA 4246359 c.3127_3129delGCCinsTG frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
embB 4246376 c.-138G>C upstream_gene_variant 0.16 ethambutol
embB 4247347 c.834G>C synonymous_variant 0.14 ethambutol
embB 4247357 p.Val282Met missense_variant 0.16 ethambutol
embB 4247365 c.852A>C synonymous_variant 0.23 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.23 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.19 ethambutol
embB 4247380 c.867C>G synonymous_variant 0.18 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.23 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.2 ethambutol
embB 4247395 c.882C>A synonymous_variant 0.22 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.32 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247446 c.933C>T synonymous_variant 0.27 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.32 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.24 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.23 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.22 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247608 c.1095G>C synonymous_variant 0.31 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.23 ethambutol
embB 4248115 c.1602C>T synonymous_variant 0.87 ethambutol Not assoc w R
embB 4248130 c.1617G>C synonymous_variant 0.18 ethambutol
embB 4248199 c.1686A>C synonymous_variant 0.16 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.16 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.25 ethambutol Uncertain significance
embB 4248211 c.1698G>C synonymous_variant 0.18 ethambutol
embB 4248217 c.1704C>G synonymous_variant 0.22 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248233 c.1720C>T synonymous_variant 0.25 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.17 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.32 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.33 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.34 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.35 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.19 ethambutol
embB 4248328 c.1815G>A synonymous_variant 0.18 ethambutol
embB 4248337 c.1824G>C synonymous_variant 0.16 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.25 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4248379 c.1866G>A synonymous_variant 0.17 ethambutol
embB 4248424 c.1911G>A synonymous_variant 0.2 ethambutol
embB 4248430 c.1917T>C synonymous_variant 0.16 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.86 ethambutol Not assoc w R
ubiA 4269177 c.657G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4269210 c.-374G>A upstream_gene_variant 0.17 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
aftB 4269225 c.-389C>A upstream_gene_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R