TB-Profiler result

Run: ERR2513283
Summary

Run ID: ERR2513283

Sample name:

Date: 2024-04-15T06:37:42.296156

Number of reads: 852554

Percentage reads mapped: 38.93

Median coverage: 21.0

Strain: lineage5.1.4

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage5 West-Africa 1 RD711 0.92
lineage5.1.4 West-Africa 1 RD711 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 660 c.660G>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.28 isoniazid
dnaA 666 c.666C>G synonymous_variant 0.26 isoniazid
dnaA 675 c.675C>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>T synonymous_variant 0.23 isoniazid
dnaA 682 c.682_684delTTGinsCC frameshift_variant&missense_variant 0.23 isoniazid Uncertain significance
dnaA 687 c.687C>T synonymous_variant 0.27 isoniazid
dnaA 693 c.693A>C synonymous_variant 0.33 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.31 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.32 isoniazid
dnaA 714 c.714C>T synonymous_variant 0.34 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.36 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 747 c.747G>T synonymous_variant 0.35 isoniazid
dnaA 748 c.748_750delCTCinsTG frameshift_variant&missense_variant 0.35 isoniazid Uncertain significance
dnaA 763 p.Lys255Arg missense_variant 0.4 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.44 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.35 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.29 isoniazid
dnaA 804 c.804G>C synonymous_variant 0.28 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.29 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.34 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.34 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.25 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.25 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.23 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.23 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 885 c.885T>C synonymous_variant 0.24 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.25 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.23 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 909 c.909A>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
gyrB 5416 c.177C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6151 c.912C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6673 c.-629A>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6739 c.-563C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6754 c.-548C>T upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6772 c.1533C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.43 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6872 c.1633_1635delTTGinsCT frameshift_variant&synonymous_variant 0.38 levofloxacin Uncertain significance
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7051 p.Glu604Asp missense_variant 0.31 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>T upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7135 c.-167G>A upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7156 c.1917C>T synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7189 c.-113C>T upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrB 7198 c.1959C>T synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7499 c.198G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7511 c.210C>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>A synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7589 c.288G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8327 c.1026C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8330 c.1029C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8580 p.Ile427Val missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8603 c.1302A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8609 c.1308G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8799 p.Ala500Ser missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8846 c.1545C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8957 c.1656C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Lys missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9377 c.2076A>G synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9392 c.2091C>T synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9566 c.2265C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13579 c.-21G>A upstream_gene_variant 1.0 isoniazid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 620328 c.438G>C synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620338 c.448_450delACCinsGG frameshift_variant&missense_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620354 p.Trp155Tyr missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620365 p.Asn159Tyr missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620397 c.507C>G synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.27 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620430 c.540C>T synonymous_variant 0.23 capreomycin
amikacin
kanamycin
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.97 ethionamide
hadA 731747 c.-183T>C upstream_gene_variant 0.31 isoniazid
hadA 731750 c.-180G>C upstream_gene_variant 0.67 isoniazid
hadA 731753 c.-177A>T upstream_gene_variant 0.33 isoniazid
hadA 731756 c.-174C>T upstream_gene_variant 0.33 isoniazid
hadA 731760 c.-170_-169delGTinsAC upstream_gene_variant 0.32 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.27 isoniazid
nusG 734445 c.192C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 0.41 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.54 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
nusG 734535 c.282C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
nusG 734580 c.327T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
nusG 734586 c.333G>C synonymous_variant 0.33 rifampicin
nusG 734782 p.Glu177Lys missense_variant 0.9 rifampicin Uncertain significance
rpoB 760101 c.295T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760110 c.304_306delTCTinsAGC synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760118 c.312T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.36 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.39 rifampicin Uncertain significance
rpoB 760276 p.Lys157Met missense_variant 0.38 rifampicin Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.36 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.38 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.48 rifampicin
rpoB 760388 c.582C>T synonymous_variant 0.5 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.5 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.52 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.32 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.34 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.34 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.34 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.36 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.42 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.42 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.43 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.43 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.36 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.39 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.23 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.24 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.47 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760886 p.Glu360Asp missense_variant 0.59 rifampicin Uncertain significance
rpoB 760887 p.Thr361Val missense_variant 0.59 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760943 c.1137C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.57 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.65 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.65 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.62 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.59 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.43 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.42 rifampicin
rpoB 761990 c.2184G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.41 rifampicin Uncertain significance
rpoB 762149 c.2343G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.35 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.47 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763450 c.81G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.45 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.4 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.4 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.44 rifampicin
rpoC 763732 c.363C>A synonymous_variant 0.4 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.38 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.36 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.36 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.56 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.56 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.56 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.53 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.55 rifampicin
rpoC 764054 c.685C>T synonymous_variant 0.55 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.52 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.47 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.47 rifampicin
rpoC 764095 c.726C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764098 c.729A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764147 c.778_780delTCGinsGC frameshift_variant&missense_variant 0.52 rifampicin
rpoC 764150 c.781_783delATCinsGG frameshift_variant&missense_variant 0.5 rifampicin
rpoC 764165 p.Glu266Gln missense_variant 0.48 rifampicin
rpoC 764176 c.807C>T synonymous_variant 0.42 rifampicin
rpoC 764177 p.Ile270Leu missense_variant 0.42 rifampicin
rpoC 764182 c.813C>T synonymous_variant 0.42 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Asn missense_variant 0.45 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.43 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.45 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.48 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.4 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.4 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.45 rifampicin
rpoC 764266 c.897T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.41 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764534 c.1165C>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.75 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.75 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.58 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.55 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.43 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765356 c.1987_1989delATGinsGC frameshift_variant&missense_variant 0.31 rifampicin
rpoC 765370 c.2001G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765379 c.2010G>C synonymous_variant 0.28 rifampicin
rpoC 765382 c.2013G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.31 rifampicin Uncertain significance
rpoC 765403 c.2034G>C synonymous_variant 0.43 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.43 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.47 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.52 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 0.52 rifampicin Uncertain significance
rpoC 765499 c.2130C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765861 p.Phe831Tyr missense_variant 0.3 rifampicin Uncertain significance
rpoC 765875 p.Val836Ile missense_variant 0.35 rifampicin Uncertain significance
rpoC 765907 c.2538G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.45 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.44 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>C synonymous_variant 0.38 rifampicin
rpoC 766009 c.2640G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.31 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.3 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.29 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.46 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766594 c.3225G>T synonymous_variant 0.35 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.3 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.25 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.26 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.26 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.24 rifampicin
rpoC 766642 c.3273C>T synonymous_variant 0.2 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.2 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.21 rifampicin
rpoC 766909 c.3540G>C synonymous_variant 0.4 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.4 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.4 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.4 rifampicin
rpoC 766931 c.3562_3564delGCAinsTG frameshift_variant&stop_gained 0.35 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767179 c.3810C>T synonymous_variant 0.49 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 0.46 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.38 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.44 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775753 c.2727delC frameshift_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776109 p.Met791Thr missense_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781586 c.27C>T synonymous_variant 0.22 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.21 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.26 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.28 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.28 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.26 streptomycin
rpsL 781658 c.99A>C synonymous_variant 0.23 streptomycin Not assoc w R - Interim
rpsL 781670 c.111G>C synonymous_variant 0.3 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.51 streptomycin
rpsL 781715 c.156T>G synonymous_variant 0.48 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.46 streptomycin
rpsL 781725 p.Lys56Arg missense_variant 0.44 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.43 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.45 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.41 streptomycin
rpsL 781737 p.Gln60Ala missense_variant 0.41 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.41 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.45 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.45 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.43 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.48 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.48 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.57 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.5 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.54 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.52 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.44 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.44 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.47 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.4 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.38 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.35 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.37 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.35 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.35 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.36 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.33 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.36 streptomycin
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
atpE 1461161 c.117C>G synonymous_variant 0.27 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.27 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.32 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.3 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.32 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.31 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.3 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.26 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.26 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
fabG1 1673338 c.-102G>A upstream_gene_variant 1.0 ethionamide
isoniazid
rpsA 1833547 c.6G>A synonymous_variant 0.3 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.48 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.46 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.45 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.5 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.59 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.57 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.57 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.52 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.51 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.51 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.5 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.51 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.51 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.54 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.49 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.49 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.46 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.48 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.37 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.34 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.33 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.36 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.39 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.5 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.6 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.6 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.64 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.63 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.67 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.71 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.71 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.74 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.7 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.66 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.66 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.61 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834073 p.Lys178Arg missense_variant 0.59 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834228 c.687C>A synonymous_variant 0.26 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.27 pyrazinamide
rpsA 1834234 c.693G>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.34 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>T synonymous_variant 0.46 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.49 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.54 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.59 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.63 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.63 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.66 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.62 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.61 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.61 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.56 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834520 c.979_981delGCCinsTG frameshift_variant&missense_variant 0.5 pyrazinamide Uncertain significance
rpsA 1834528 c.987T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834534 c.993C>T synonymous_variant 0.51 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.54 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.46 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.46 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.47 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.29 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834645 c.1104C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.34 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834698 c.1157_1158insC frameshift_variant 0.34 pyrazinamide Uncertain significance
rpsA 1834701 p.Gln387Pro missense_variant 0.35 pyrazinamide
rpsA 1834704 c.1164delC frameshift_variant 0.39 pyrazinamide Uncertain significance
rpsA 1834720 c.1179C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.37 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.4 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.43 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.39 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.29 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.29 linezolid
tsnR 1853372 c.-234A>G upstream_gene_variant 0.31 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.29 linezolid
tsnR 1853381 c.-225C>T upstream_gene_variant 0.24 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.23 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.25 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.24 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.25 linezolid
tsnR 1853565 c.-41G>A upstream_gene_variant 0.96 linezolid Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2101921 c.1122G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2103112 c.-70G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2290062 c.-821G>A upstream_gene_variant 1.0 pyrazinamide
kasA 2517917 c.-198G>C upstream_gene_variant 0.65 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.61 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.57 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.51 isoniazid
kasA 2517968 c.-147T>A upstream_gene_variant 0.44 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.36 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
Rv2477c 2783302 c.741A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783347 c.696C>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
ald 3087184 c.368_373delCCGACG disruptive_inframe_deletion 1.0 cycloserine
Rv3083 3449507 p.Arg335Gln missense_variant 1.0 ethionamide
Rv3236c 3613591 c.-475G>A upstream_gene_variant 1.0 pyrazinamide
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3624919 p.Trp565Cys missense_variant 1.0 bedaquiline
rifampicin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625705 c.909C>G synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625708 c.906C>T synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625720 c.894G>C synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625744 c.870G>A synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.44 bedaquiline
rifampicin Uncertain significance
mtrB 3625761 p.Gln285Glu missense_variant 0.42 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625783 c.-873C>T upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625813 c.801C>T synonymous_variant 0.32 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625819 p.Glu265Val missense_variant 0.29 bedaquiline
rifampicin Uncertain significance
mtrB 3625837 c.777C>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626669 c.-56T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626681 c.-68C>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626684 c.-71G>A upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626756 c.594C>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626786 c.564A>G synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.55 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626825 c.525T>A synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626908 p.Asn148Asp missense_variant 0.22 bedaquiline
rifampicin
mtrA 3627053 c.297C>T synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627056 c.294C>T synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627059 c.291G>T synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627068 c.282T>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627073 c.277C>T synonymous_variant 0.36 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
alr 3840932 c.489C>T synonymous_variant 1.0 cycloserine
rpoA 3877542 c.966C>A synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877545 c.963G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877548 c.960C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877554 c.954G>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877560 c.948C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsAC frameshift_variant&missense_variant 0.56 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877614 c.894G>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877620 c.888G>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877677 c.831G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.42 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.36 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.38 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.38 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.38 rifampicin
rpoA 3877755 c.753C>T synonymous_variant 0.38 rifampicin
rpoA 3877758 c.750G>C synonymous_variant 0.39 rifampicin
rpoA 3877764 c.744C>A synonymous_variant 0.39 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.39 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877797 c.711G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877824 c.684G>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>A synonymous_variant 0.69 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.57 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.46 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877977 p.Lys177Asn missense_variant 0.44 rifampicin Uncertain significance
rpoA 3877986 c.522G>T synonymous_variant 0.38 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.25 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.26 rifampicin
rpoA 3878142 p.Gly122Asp missense_variant 0.29 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.56 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878343 c.165C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.27 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.28 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.26 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.22 rifampicin
rpoA 3878373 c.135G>C synonymous_variant 0.25 rifampicin
rpoA 3878381 c.127C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878878 c.-371T>C upstream_gene_variant 0.43 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.5 rifampicin
rpoA 3878887 c.-382_-380delAACinsGT upstream_gene_variant 0.46 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.5 rifampicin
rpoA 3878900 c.-394_-393delGGinsAA upstream_gene_variant 0.4 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.38 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.32 rifampicin
rpoA 3878929 c.-422G>C upstream_gene_variant 0.32 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.32 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3879088 c.-581A>C upstream_gene_variant 0.32 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879097 c.-590C>T upstream_gene_variant 0.31 rifampicin
rpoA 3879121 c.-615_-614delTTinsAG upstream_gene_variant 0.44 rifampicin
rpoA 3879124 c.-618_-617delTGinsGC upstream_gene_variant 0.44 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.44 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.38 rifampicin
ddn 3986870 c.27G>C synonymous_variant 1.0 delamanid
pretomanid
ddn 3986987 c.144G>T synonymous_variant 1.0 delamanid Not assoc w R - Interim
pretomanid
ddn 3987180 p.Asp113Asn missense_variant 1.0 delamanid Uncertain significance
pretomanid
clpC1 4038740 c.1965G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.22 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.23 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.26 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.34 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.39 pyrazinamide
clpC1 4038857 c.1848C>G synonymous_variant 0.42 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.45 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.46 pyrazinamide
clpC1 4038923 c.1782A>T synonymous_variant 0.43 pyrazinamide
clpC1 4038928 c.1777C>A synonymous_variant 0.4 pyrazinamide
clpC1 4038929 c.1776G>A synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038932 c.1773G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.37 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039077 p.Lys543Arg missense_variant 0.32 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.45 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.46 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.37 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.33 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.32 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039265 c.1440C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.4 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039286 c.1417_1419delCTTinsTA frameshift_variant&synonymous_variant 0.42 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.42 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.41 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 0.39 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.44 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.46 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>A synonymous_variant 0.46 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.48 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.47 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039619 c.1086G>A synonymous_variant 0.46 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.48 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039685 c.1020C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039733 c.972G>A synonymous_variant 0.49 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.52 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.43 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039868 c.837C>T synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.77 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039957 c.748C>T synonymous_variant 0.69 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.69 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.6 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>G synonymous_variant 0.57 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.55 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.52 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.56 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.56 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.49 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040174 c.531C>T synonymous_variant 0.36 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040300 c.405C>T synonymous_variant 0.32 pyrazinamide
clpC1 4040309 c.396C>T synonymous_variant 0.42 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040342 c.363C>A synonymous_variant 0.34 pyrazinamide
clpC1 4040348 c.357G>T synonymous_variant 0.36 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.33 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.3 pyrazinamide
clpC1 4040366 c.339C>T synonymous_variant 0.3 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.4 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.4 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.58 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.54 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.49 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.43 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.44 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>T synonymous_variant 0.55 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.51 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.46 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.45 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.49 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.49 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.44 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.44 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.43 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040824 c.-120C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 0.91 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138601 c.1155G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138616 c.1140G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>A synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>G synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138664 c.1092G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.44 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138694 p.Pro354Glu missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138712 p.Ala348Asp missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1030_1032delGCAinsTG frameshift_variant&missense_variant 0.43 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138730 c.1026C>T synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138772 c.984G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139131 p.Glu209Lys missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Uncertain significance
embC 4239843 c.-20A>C upstream_gene_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240756 c.894G>C synonymous_variant 0.35 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.34 ethambutol
embC 4240772 p.Ser304Ala missense_variant 0.34 ethambutol
embC 4240778 p.His306Gly missense_variant 0.32 ethambutol
embC 4240781 p.Ala307Ser missense_variant 0.32 ethambutol Uncertain significance
embC 4240789 c.927T>C synonymous_variant 0.33 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.33 ethambutol
embC 4240826 p.Ala322Ser missense_variant 0.3 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.31 ethambutol
embC 4240856 c.994_996delGCGinsAC frameshift_variant&missense_variant 0.19 ethambutol
embC 4240859 c.997_999delCTGinsAC frameshift_variant&missense_variant 0.19 ethambutol
embC 4240876 c.1014C>T synonymous_variant 0.19 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244635 p.Val468Ala missense_variant 1.0 ethambutol Not assoc w R - Interim
embA 4245147 p.Pro639Ser missense_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326928 c.546C>T synonymous_variant 0.95 ethionamide Not assoc w R - Interim
ethA 4327103 p.Gly124Asp missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338546 c.-25G>A upstream_gene_variant 0.97 capreomycin
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R