TB-Profiler result

Run: SRR1181091
Summary

Run ID: SRR1181091

Sample name:

Date: 2024-04-15T10:02:26.493901

Number of reads: 2728711

Percentage reads mapped: 61.86

Median coverage: 61.0

Strain: lineage2.2.1.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.97
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
lineage2.2.1.1 East-Asian (Beijing) RD105;RD207;RD181;RD150 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247448 p.His312Arg missense_variant 0.17 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1035 c.1035A>G synonymous_variant 0.18 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.19 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.19 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.27 isoniazid
dnaA 1107 c.1107C>T synonymous_variant 0.21 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.24 isoniazid
dnaA 1122 c.1122C>A synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1125 c.1125G>C synonymous_variant 0.19 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.18 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.17 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.18 isoniazid
dnaA 1199 p.Arg400His missense_variant 0.81 isoniazid Uncertain significance
dnaA 1245 c.1245G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.28 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.23 isoniazid
dnaA 1317 c.1317A>C synonymous_variant 0.16 isoniazid
gyrB 5284 c.45G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 5287 c.48T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 5293 c.54C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 5305 c.66G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 5308 c.69G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6145 c.906C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6259 p.Asp340Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6331 c.-971A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6721 c.1482C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6730 c.-572A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6781 c.-521C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6856 c.1617T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6866 c.-436C>T upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7625 c.324G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7793 c.492G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7838 c.537C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7841 c.540C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8321 c.1020C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.17 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8576 c.1275C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8655 p.Ile452Val missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8664 c.1363C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8723 c.1422G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8818 p.Ser506Asn missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8855 c.1554C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8858 c.1557T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8876 c.1575C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8957 c.1656C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490818 c.36C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490830 c.48A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575512 c.165A>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575524 c.177G>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575530 c.183C>T synonymous_variant 0.24 ethionamide
isoniazid
mshA 575539 c.192C>T synonymous_variant 0.28 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575548 c.201C>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575557 c.210C>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575561 p.Met72Val missense_variant 0.33 ethionamide
isoniazid
mshA 575576 c.229C>T synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575581 c.234C>T synonymous_variant 0.28 ethionamide
isoniazid
mshA 575590 c.243T>G synonymous_variant 0.35 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.84 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.17 ethionamide
Rv0565c 657690 c.-220C>A upstream_gene_variant 0.18 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.22 ethionamide
hadA 731768 c.-162G>A upstream_gene_variant 0.18 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.29 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.2 isoniazid
hadA 731798 c.-132C>G upstream_gene_variant 0.2 isoniazid
hadA 731825 c.-105G>C upstream_gene_variant 0.18 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.22 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.17 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.19 isoniazid
hadA 731861 c.-69G>A upstream_gene_variant 0.15 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.16 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.17 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.22 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.19 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.2 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.19 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.2 rifampicin
nusG 734793 c.540C>T synonymous_variant 0.15 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.19 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.21 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.28 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.17 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.27 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760145 c.339C>G synonymous_variant 0.19 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.16 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.17 rifampicin
rpoB 760307 c.501T>C synonymous_variant 0.28 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.19 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.27 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760356 c.550_552delACCinsTG frameshift_variant&missense_variant 0.18 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.19 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.19 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.24 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.27 rifampicin Uncertain significance
rpoB 760533 p.Val243His missense_variant 0.21 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760556 c.750G>A synonymous_variant 0.22 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.25 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.28 rifampicin
rpoB 760598 c.792C>T synonymous_variant 0.22 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.23 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.18 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.19 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760845 c.1039_1041delACCinsTG frameshift_variant&missense_variant 0.21 rifampicin
rpoB 760850 c.1044G>C synonymous_variant 0.19 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760862 c.1056G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.22 rifampicin
rpoB 760877 c.1071G>T synonymous_variant 0.3 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.33 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.24 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.2 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.17 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>T synonymous_variant 0.23 rifampicin
rpoB 760970 c.1164G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.15 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.2 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.18 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.19 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.19 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.25 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.24 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.34 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.26 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.21 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.21 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.21 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.19 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.21 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.19 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.22 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.21 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.2 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.25 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761540 c.1734C>T synonymous_variant 0.24 rifampicin
rpoB 761561 c.1755C>G synonymous_variant 0.39 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761582 c.1776G>A synonymous_variant 0.35 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.44 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.41 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.25 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.24 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.25 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.24 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.18 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.18 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.16 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.16 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.19 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.21 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.18 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.17 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.16 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>A synonymous_variant 0.21 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.22 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.3 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.27 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.25 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.26 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.25 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.21 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.21 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761955 p.Ile717Val missense_variant 0.18 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.2 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.22 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762050 c.2244G>A synonymous_variant 0.24 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.35 rifampicin Uncertain significance
rpoB 762138 c.2332C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.23 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.18 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.26 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.34 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.34 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.22 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.25 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.2 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.22 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.26 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.21 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.25 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.17 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762507 c.2701_2703delCTTinsAG frameshift_variant&missense_variant 0.2 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.21 rifampicin Uncertain significance
rpoC 762524 c.-846G>C upstream_gene_variant 0.17 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.2 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.19 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.19 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.17 rifampicin
rpoB 762833 c.3027C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762920 c.-450C>G upstream_gene_variant 0.27 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.22 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 0.22 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>A upstream_gene_variant 0.26 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.18 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.21 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.27 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.18 rifampicin
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 0.18 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.31 rifampicin
rpoC 763423 c.54G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.25 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>A synonymous_variant 0.27 rifampicin
rpoC 763573 c.204G>T synonymous_variant 0.24 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>A synonymous_variant 0.22 rifampicin
rpoC 763618 c.249C>T synonymous_variant 0.23 rifampicin
rpoC 763621 c.252C>G synonymous_variant 0.22 rifampicin
rpoC 763636 c.267T>G synonymous_variant 0.26 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763681 c.312C>A synonymous_variant 0.25 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.26 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.3 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.41 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.27 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.39 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.41 rifampicin
rpoC 763768 c.399C>T synonymous_variant 0.28 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.35 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.23 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.21 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.21 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.21 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.2 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.23 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.24 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.27 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.38 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.42 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.4 rifampicin
rpoC 763969 c.600C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.51 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.47 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764024 c.655T>C synonymous_variant 0.4 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.3 rifampicin
rpoC 764044 c.675T>G synonymous_variant 0.29 rifampicin
rpoC 764056 c.687G>T synonymous_variant 0.28 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.37 rifampicin
rpoC 764080 c.711C>T synonymous_variant 0.33 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.44 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>G synonymous_variant 0.33 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.19 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>A synonymous_variant 0.3 rifampicin
rpoC 764260 c.891G>A synonymous_variant 0.26 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.27 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.17 rifampicin
rpoC 764272 c.903G>T synonymous_variant 0.16 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.17 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.4 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.33 rifampicin
rpoC 764339 c.970C>T synonymous_variant 0.32 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.38 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.29 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.27 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.27 rifampicin
rpoC 764452 c.1083T>G synonymous_variant 0.24 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.19 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.37 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.23 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.26 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.25 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.23 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764782 c.1413C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.24 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.31 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.17 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765404 c.2035C>T synonymous_variant 0.21 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.23 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.2 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>T synonymous_variant 0.26 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>A synonymous_variant 0.36 rifampicin
rpoC 765529 c.2160C>T synonymous_variant 0.28 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.32 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.33 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.3 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.31 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.27 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.3 rifampicin
rpoC 765592 c.2223C>T synonymous_variant 0.23 rifampicin
rpoC 765622 p.Glu751Asp missense_variant 0.21 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765685 c.2316G>A synonymous_variant 0.28 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Lys missense_variant 0.27 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.24 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.23 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.23 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.23 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.27 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.25 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.25 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.26 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.32 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.32 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765907 c.2538G>A synonymous_variant 0.29 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.33 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.17 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765991 c.2622C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.15 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.28 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.24 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.3 rifampicin
rpoC 766096 c.2727G>T synonymous_variant 0.3 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.31 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.26 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.19 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766148 p.Thr927Ala missense_variant 0.17 rifampicin Uncertain significance
rpoC 766369 c.3000C>G synonymous_variant 0.15 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.27 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.26 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.18 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.2 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.29 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.24 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.32 rifampicin
rpoC 766492 c.3123T>A synonymous_variant 0.28 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.3 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.32 rifampicin
rpoC 766540 c.3171C>T synonymous_variant 0.32 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.35 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.33 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.3 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.36 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.35 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.36 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.45 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.35 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.24 rifampicin
rpoC 766666 c.3297C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.34 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.34 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.33 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.35 rifampicin
rpoC 766801 c.3432C>A synonymous_variant 0.25 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.23 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.21 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.21 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.21 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.18 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.19 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.17 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.38 rifampicin
rpoC 767044 c.3675G>A synonymous_variant 0.33 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.42 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.34 rifampicin
rpoC 767152 c.3783T>G synonymous_variant 0.31 rifampicin
rpoC 767158 c.3789T>A synonymous_variant 0.33 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.33 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 0.33 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.35 rifampicin
rpoC 767209 c.3840T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.25 rifampicin
rpoC 767275 c.3906T>A synonymous_variant 0.23 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.22 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.21 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781301 c.-259C>T upstream_gene_variant 1.0 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.23 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.23 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.22 streptomycin
rpsL 781703 c.144G>A synonymous_variant 0.23 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.28 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.28 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.31 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.23 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.2 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.19 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.28 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.18 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781820 c.261G>T synonymous_variant 0.26 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.32 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.28 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.28 streptomycin
rpsL 781886 c.327C>T synonymous_variant 0.2 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.28 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.28 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.29 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.26 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.16 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.18 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.3 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.32 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.3 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.29 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.29 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.29 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.23 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.3 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.24 linezolid
rplC 800715 c.-94_-92delATCinsCT upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.24 linezolid
rplC 800744 c.-65G>A upstream_gene_variant 0.16 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.17 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.17 linezolid
rplC 801312 c.504G>C synonymous_variant 0.21 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302818 c.-113G>C upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303506 c.576C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303537 p.Arg203Leu missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303542 c.612C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304757 c.1827A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304877 p.Ile649Met missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304896 c.1966C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304915 p.Asp662Gly missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
sigE 1364955 c.543G>C synonymous_variant 0.16 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.16 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.18 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.18 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.15 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461185 c.141G>A synonymous_variant 0.17 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.19 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471935 n.90T>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473987 n.330G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474002 n.345G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474007 n.350A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474156 n.499G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474163 n.506C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474285 n.629C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474303 n.646A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474409 n.756_774delACCCACACGCGCATACGCG non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475005 n.1348C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475402 n.1745delC non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475446 n.1789G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475453 n.1796T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475487 n.1830C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475605 n.1948A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475617 n.1960C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475625 n.1968G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475637 n.1980T>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475759 n.2102_2106delCCCGCinsTCGT non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475999 n.2342G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476047 n.2390G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476077 n.2420T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476104 n.2448delG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476595 n.2938C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476602 n.2945G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
inhA 1673547 c.-655T>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673712 c.-490A>C upstream_gene_variant 0.18 ethionamide
isoniazid Uncertain significance
inhA 1673727 c.-475C>T upstream_gene_variant 0.16 ethionamide
isoniazid Uncertain significance
fabG1 1673733 p.Met98Ile missense_variant 0.2 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.25 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.25 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.22 ethionamide
isoniazid
inhA 1673982 c.-220G>C upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673988 c.-214G>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673991 c.-211C>G upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1674015 c.-187C>A upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1674018 c.-184G>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1674840 c.639C>T synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674846 p.Ile215Met missense_variant 0.22 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674900 c.699G>A synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.17 ethionamide
isoniazid
inhA 1674927 c.726G>A synonymous_variant 0.16 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rpsA 1833554 p.Thr5Ala missense_variant 0.24 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.24 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.22 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1833782 p.Ser81Thr missense_variant 0.18 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834024 c.483G>A synonymous_variant 0.19 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.23 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834234 c.693G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834255 c.714C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834258 c.717G>A synonymous_variant 0.16 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.19 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834556 p.Ala339Thr missense_variant 0.19 pyrazinamide Uncertain significance
rpsA 1834609 c.1068T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834615 c.1074C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834624 c.1083G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.25 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.21 pyrazinamide
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.23 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.17 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.22 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.16 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.19 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.2 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.18 linezolid
tsnR 1853468 c.-138C>T upstream_gene_variant 0.19 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.19 linezolid
tsnR 1853485 c.-121G>C upstream_gene_variant 0.18 linezolid
tsnR 1853489 c.-117C>T upstream_gene_variant 0.17 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.19 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064271 p.Trp153Ser missense_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
ndh 2101980 p.Asn355Asp missense_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101999 c.1044G>A synonymous_variant 0.23 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102020 c.1023A>G synonymous_variant 0.17 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223014 p.Tyr51Asn missense_variant 0.98 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.29 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.23 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.17 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.17 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.21 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.24 isoniazid
kasA 2518567 c.453G>T synonymous_variant 0.22 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.18 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.19 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.21 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.22 isoniazid
kasA 2518735 c.621C>A synonymous_variant 0.18 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.21 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.16 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.17 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.19 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.22 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.19 isoniazid
kasA 2518910 c.796C>T synonymous_variant 0.17 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.21 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.21 isoniazid
kasA 2518951 c.837G>A synonymous_variant 0.2 isoniazid
kasA 2518960 c.846C>G synonymous_variant 0.22 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.22 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.2 isoniazid
kasA 2518978 c.864T>C synonymous_variant 0.16 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.16 isoniazid
kasA 2519161 c.1047G>A synonymous_variant 0.21 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.2 isoniazid
eis 2714846 p.Val163Ile missense_variant 0.98 amikacin Not assoc w R
kanamycin Not assoc w R
Rv2477c 2783194 c.849A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.616_618delCCCinsGG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783428 c.615C>T synonymous_variant 0.21 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783449 c.594C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783548 c.495T>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783650 c.393C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783659 c.384A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783842 c.201C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 p.Tyr29Phe missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065595 p.Leu199Phe missense_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065612 p.Thr194Ala missense_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065916 c.276T>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065947 p.Gly82Ala missense_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065949 c.243C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065958 c.234G>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066426 c.-235T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067316 c.630A>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067331 c.615C>T synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073932 c.540C>T synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073983 c.489C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.18 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624701 c.210T>A synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625537 c.-627T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625663 c.-753G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625669 c.-759G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625693 c.-783G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625708 c.906C>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.19 bedaquiline
rifampicin Uncertain significance
mtrB 3625804 c.808_810delAGGinsCA frameshift_variant&missense_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625822 c.-912C>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626798 c.-185T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626819 c.-206G>A upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626942 c.-329A>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627101 c.-488C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627104 c.-491C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627122 c.-509T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627140 c.-527G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.26 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.22 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.16 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.16 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.18 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.15 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.23 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.22 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.21 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.25 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.21 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.16 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.15 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.3 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.29 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.17 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.29 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878295 c.213A>G synonymous_variant 0.29 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.16 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>C synonymous_variant 0.18 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878406 c.102G>T synonymous_variant 0.22 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.17 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.16 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.17 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.17 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.18 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.34 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878837 c.-331_-330delAAinsGG upstream_gene_variant 0.25 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.35 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.18 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3879006 c.-499A>C upstream_gene_variant 0.23 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.28 rifampicin
rpoA 3879033 c.-526C>T upstream_gene_variant 0.2 rifampicin
rpoA 3879034 c.-527G>C upstream_gene_variant 0.2 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.19 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.21 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.29 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.27 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879190 c.-683C>T upstream_gene_variant 0.2 rifampicin
ddn 3986615 c.-229C>T upstream_gene_variant 0.27 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.24 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.23 delamanid
pretomanid
clpC1 4038278 c.2427T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038289 p.Asn806Asp missense_variant 0.27 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038323 c.2382C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038329 p.Glu792Asp missense_variant 0.28 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.32 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.31 pyrazinamide
clpC1 4038461 c.2244G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 0.17 pyrazinamide
clpC1 4038486 p.Gly740Thr missense_variant 0.17 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.2 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.35 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.33 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.35 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.23 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.23 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038692 c.2013C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038815 c.1890G>A synonymous_variant 0.17 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.3 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.37 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.37 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.34 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.35 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.35 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039021 c.1684C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039140 p.Glu522Val missense_variant 0.19 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.21 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039238 c.1467C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039268 c.1437C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039274 c.1431G>T synonymous_variant 0.22 pyrazinamide
clpC1 4039277 c.1428C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039319 c.1384_1386delGCTinsAC frameshift_variant&missense_variant 0.23 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039328 c.1377A>T synonymous_variant 0.19 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.21 pyrazinamide
clpC1 4039355 c.1350G>T synonymous_variant 0.21 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.2 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039472 c.1233G>T synonymous_variant 0.18 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039715 c.990G>A synonymous_variant 0.3 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039727 c.978C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>T synonymous_variant 0.27 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.25 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040030 c.675C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.17 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040288 c.417C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040321 c.384C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040537 c.168G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040549 c.154_156delTTGinsCT frameshift_variant&missense_variant 0.18 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040597 c.108C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.16 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.17 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.17 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.17 pyrazinamide
glpK 4139165 c.591A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.573T>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
embC 4240486 c.624G>A synonymous_variant 0.19 ethambutol
embC 4240717 c.855T>C synonymous_variant 0.2 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4240741 c.879C>T synonymous_variant 0.23 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.29 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.22 ethambutol
embC 4240811 c.949_951delTTCinsCA frameshift_variant&missense_variant 0.19 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.19 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.19 ethambutol
embC 4240837 c.975C>G synonymous_variant 0.17 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244885 c.1653A>G synonymous_variant 0.23 ethambutol
embA 4244886 c.1654C>T synonymous_variant 0.23 ethambutol
embA 4244897 c.1665T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embA 4244900 c.1668G>C synonymous_variant 0.2 ethambutol
embA 4244904 p.Val558Leu missense_variant 0.21 ethambutol Uncertain significance
embA 4244909 c.1677C>G synonymous_variant 0.21 ethambutol
embA 4244916 c.1684C>T synonymous_variant 0.18 ethambutol
embA 4244921 c.1689C>G synonymous_variant 0.18 ethambutol
embB 4246346 c.-168C>G upstream_gene_variant 0.18 ethambutol
embA 4246359 c.3127_3129delGCCinsTG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
embB 4246373 c.-141T>C upstream_gene_variant 0.15 ethambutol
embB 4247089 c.576G>C synonymous_variant 0.21 ethambutol
embB 4247095 c.582G>A synonymous_variant 0.22 ethambutol
embB 4247365 c.852A>C synonymous_variant 0.19 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.21 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.18 ethambutol
embB 4247380 c.867C>G synonymous_variant 0.16 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.21 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.15 ethambutol
embB 4247395 c.882C>A synonymous_variant 0.15 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.2 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.22 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.27 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.27 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.29 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.16 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.16 ethambutol Uncertain significance
embB 4248044 c.1531_1533delAAAinsGC frameshift_variant&missense_variant 0.16 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.32 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.32 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.21 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.23 ethambutol
embB 4248115 c.1602C>T synonymous_variant 0.82 ethambutol Not assoc w R
embB 4248142 c.1629T>C synonymous_variant 0.17 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.2 ethambutol Uncertain significance
embB 4248217 c.1704C>G synonymous_variant 0.23 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248233 c.1720C>T synonymous_variant 0.25 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.14 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.33 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.33 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.39 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.39 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.19 ethambutol
embB 4248328 c.1815G>A synonymous_variant 0.2 ethambutol
embB 4248334 c.1821C>G synonymous_variant 0.18 ethambutol
embB 4248337 c.1824G>C synonymous_variant 0.19 ethambutol
embB 4248349 c.1836G>A synonymous_variant 0.19 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.17 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.34 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embB 4248379 c.1866G>A synonymous_variant 0.2 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.16 ethambutol
aftB 4267622 c.1213_1215delTCGinsAGC synonymous_variant 0.22 ethambutol
aftB 4267625 c.1212T>C synonymous_variant 0.16 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.2 ethambutol
aftB 4267647 p.Asp397Cys missense_variant 0.77 ethambutol
aftB 4267655 c.1182C>G synonymous_variant 0.2 ethambutol
aftB 4267670 c.1167G>A synonymous_variant 0.18 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
aftB 4269164 c.-328T>C upstream_gene_variant 0.15 ethambutol
ubiA 4269177 c.657G>A synonymous_variant 0.15 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R