TB-Profiler result

Run: ERR4819932
Summary

Run ID: ERR4819932

Sample name:

Date: 2024-04-15T16:27:43.025997

Number of reads: 4352972

Percentage reads mapped: 68.11

Median coverage: 94.0

Strain: lineage4.7

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.2.BCG M.bovis None 0.11
lineage4.7 Euro-American (mainly T) None 1.0
lineage4 Euro-American None 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.604_606delTCGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303534 c.604_606delTCGinsGC frameshift_variant&missense_variant 0.19 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.17 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1014 c.1014C>G synonymous_variant 0.16 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.19 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.23 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.24 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.25 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.21 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.19 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.18 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.17 isoniazid
dnaA 1254 c.1254T>C synonymous_variant 0.16 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.16 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.15 isoniazid
gyrB 5776 c.537T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 5782 c.543A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 5788 c.549G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 5791 c.552A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 5803 c.564A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 5806 c.567C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 5809 c.570C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 5824 c.585A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 5827 c.588G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 5849 c.610C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 5854 c.615C>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 5863 c.624G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6418 c.-884C>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.23 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.25 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.23 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7307 c.6A>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7334 c.33G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7335 p.Leu12Val missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7347 c.46_48delGAAinsCG frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.27 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.17 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8767 p.Arg489Lys missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.22 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
Rv0010c 13893 c.-335T>G upstream_gene_variant 0.19 isoniazid
Rv0010c 13897 c.-339C>T upstream_gene_variant 0.19 isoniazid
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.21 isoniazid
Rv0010c 13909 c.-351G>C upstream_gene_variant 0.21 isoniazid
fgd1 490803 c.21T>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491173 c.391C>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491307 c.525C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491325 c.543G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491535 c.753G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
mshA 575719 c.372C>T synonymous_variant 0.17 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.2 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.21 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.19 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.18 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.26 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.27 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.26 ethionamide
isoniazid Not assoc w R - Interim
mshA 575884 c.537G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.18 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>T upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>T synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.17 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.16 capreomycin
amikacin
kanamycin
Rv0565c 656418 c.1053A>G synonymous_variant 0.18 ethionamide
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.2 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.23 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.21 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.21 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.2 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.17 ethionamide
Rv0565c 656487 c.984T>C synonymous_variant 0.16 ethionamide Not assoc w R - Interim
Rv0565c 656493 c.978C>G synonymous_variant 0.16 ethionamide
Rv0565c 656502 c.969C>T synonymous_variant 0.15 ethionamide
Rv0565c 657237 c.234A>G synonymous_variant 0.16 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.2 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.2 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.21 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.21 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.24 ethionamide
Rv0565c 657303 c.168C>T synonymous_variant 0.23 ethionamide Not assoc w R - Interim
Rv0565c 657318 c.153T>C synonymous_variant 0.23 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.2 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.2 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.18 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.16 ethionamide
hadA 731789 c.-141A>G upstream_gene_variant 0.17 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.17 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.17 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.17 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.2 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.21 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.21 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.22 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.26 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.27 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.22 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.22 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.22 isoniazid
nusG 734421 c.168A>G synonymous_variant 0.2 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.21 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.24 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.26 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.27 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.27 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.3 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.28 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.19 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.17 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.17 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.18 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.18 rifampicin
nusG 734841 c.588G>C synonymous_variant 0.19 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.19 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.2 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.2 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.2 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.18 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.22 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.19 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.28 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.25 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.25 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.26 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.24 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.29 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.27 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.28 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.31 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.33 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.3 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.29 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.29 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.33 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.27 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.23 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.22 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.19 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.19 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.21 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.2 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.2 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.29 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.3 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.3 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.38 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.31 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.29 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.36 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.37 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.33 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.3 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.3 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.3 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.26 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.24 rifampicin
rpoB 761373 p.Val523Gln missense_variant 0.18 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.16 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.16 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.31 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.29 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.24 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.28 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.16 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.15 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.2 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.2 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.17 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.17 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.17 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.2 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.21 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.18 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.24 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.34 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.26 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.23 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.23 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.33 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.38 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.38 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.39 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.38 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.35 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.31 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.34 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.38 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.26 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.24 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.28 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.29 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.25 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.24 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.2 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.27 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.26 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.21 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.2 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.2 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.17 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.3 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.36 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.35 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.34 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.29 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.19 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.21 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.24 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.3 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.33 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.31 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.21 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.24 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.26 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.28 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.34 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.32 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.38 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.32 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.29 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.27 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.28 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.28 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.29 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.25 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.25 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.25 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.26 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.25 rifampicin
rpoC 763942 c.573C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763948 c.579G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763949 c.580C>A synonymous_variant 0.3 rifampicin
rpoC 763954 c.585C>G synonymous_variant 0.3 rifampicin
rpoC 763963 c.594C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764044 c.675T>C synonymous_variant 0.18 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.21 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.27 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.27 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.3 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.3 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.25 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.25 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.32 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.3 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.28 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.27 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.28 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.16 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.3 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.35 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.35 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.2 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.26 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.27 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.27 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.3 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.37 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.39 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.37 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.28 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.23 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.23 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.21 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.17 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.15 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765346 c.1977C>G synonymous_variant 0.17 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.28 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.31 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.28 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.25 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.22 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.19 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.18 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.17 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.25 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.29 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.24 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.2 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.19 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.2 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.21 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.2 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.2 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.2 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.3 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.3 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.29 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.24 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.22 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.25 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.24 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.21 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.24 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.21 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.22 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.17 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.15 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.16 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.16 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.16 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.19 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.23 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.24 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.22 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.22 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.23 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.21 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.21 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.21 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.19 rifampicin
rpoC 766549 c.3180G>T synonymous_variant 0.18 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.16 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.17 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.21 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.17 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.22 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.23 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.2 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.19 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.23 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.28 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.26 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.25 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.25 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.3 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.3 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.3 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.27 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.27 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.27 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.28 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.3 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.35 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.26 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.23 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.18 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 0.99 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775966 p.Ala839Ser missense_variant 0.25 clofazimine
bedaquiline
mmpL5 775975 c.2506T>C synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.23 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 776000 c.2481G>C synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 776705 c.1776C>T synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 777133 p.Val450Ile missense_variant 0.18 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.25 clofazimine
bedaquiline
mmpL5 777191 c.1290C>G synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 777212 c.1267_1269delGCCinsAG frameshift_variant&missense_variant 0.18 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 777215 c.1266C>G synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 777218 c.1263G>A synonymous_variant 0.18 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.16 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.22 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.22 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.22 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.29 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.29 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.38 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.35 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.29 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.28 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.29 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.3 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.29 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.3 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.29 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.3 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.31 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.3 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.31 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.31 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.32 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.32 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.35 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.34 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.32 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.32 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.33 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.35 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.32 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.24 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.14 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.2 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.21 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.23 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.22 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.23 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.18 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.18 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.18 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.21 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.28 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.28 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.29 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.28 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.29 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.26 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.26 linezolid
rplC 800814 c.6A>G synonymous_variant 0.17 linezolid
rplC 800817 c.9A>T synonymous_variant 0.16 linezolid
rplC 800844 c.36T>C synonymous_variant 0.16 linezolid
rplC 801153 c.345G>C synonymous_variant 0.16 linezolid
rplC 801168 c.360C>G synonymous_variant 0.22 linezolid
rplC 801171 c.363A>G synonymous_variant 0.22 linezolid
rplC 801174 c.366T>C synonymous_variant 0.21 linezolid
rplC 801195 c.387G>C synonymous_variant 0.23 linezolid
rplC 801207 c.399C>T synonymous_variant 0.26 linezolid
rplC 801246 c.438C>T synonymous_variant 0.21 linezolid
rplC 801249 c.441T>C synonymous_variant 0.21 linezolid
rplC 801255 c.447C>T synonymous_variant 0.22 linezolid
rplC 801300 c.492C>G synonymous_variant 0.18 linezolid
rplC 801321 c.513C>T synonymous_variant 0.18 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.19 linezolid
rplC 801339 c.531T>C synonymous_variant 0.18 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.18 linezolid
rplC 801348 c.540T>G synonymous_variant 0.22 linezolid
rplC 801357 c.549T>C synonymous_variant 0.22 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.26 linezolid
rplC 801402 c.594T>C synonymous_variant 0.18 linezolid
rplC 801405 c.597T>C synonymous_variant 0.18 linezolid
fbiC 1303530 c.600G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304161 p.Arg411Ser missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304187 c.1257T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304208 c.1278C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304739 c.1809C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.54 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304862 c.1932G>A synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
atpE 1460831 c.-214T>C upstream_gene_variant 0.2 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.22 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.18 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.18 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.18 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.18 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.19 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.21 bedaquiline
atpE 1460897 c.-148A>C upstream_gene_variant 0.22 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.21 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.23 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.22 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.22 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.2 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
fabG1 1673641 p.Val68Ile missense_variant 0.14 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.22 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.3 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.27 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.26 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.18 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.18 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.17 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.15 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.18 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.17 ethionamide
isoniazid
inhA 1674105 c.-97C>T upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674114 c.-88T>A upstream_gene_variant 0.15 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674504 c.303C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.18 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.15 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674741 c.540C>T synonymous_variant 0.16 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674746 p.Tyr182Phe missense_variant 0.15 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.19 ethionamide
isoniazid
inhA 1674864 c.663C>T synonymous_variant 0.2 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674888 c.687C>G synonymous_variant 0.16 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.22 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.41 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.18 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.4 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.36 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.32 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.31 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.31 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.25 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.3 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.26 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.22 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.21 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.17 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.17 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.17 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.17 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064897 c.-169C>G upstream_gene_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064903 c.-175G>A upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064912 c.-184A>G upstream_gene_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064915 c.-187G>C upstream_gene_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101939 c.1104A>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101963 c.1080G>A synonymous_variant 0.24 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Asp missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101993 c.1050A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102014 c.1029C>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.16 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102695 c.348C>T synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102700 c.343C>T synonymous_variant 0.17 ethionamide
delamanid
isoniazid
katG 2155680 c.432G>C synonymous_variant 0.19 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.2 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.22 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.2 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.19 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.19 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.19 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.39 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.3 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.29 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.14 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.17 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.22 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.27 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.29 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.28 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.28 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.25 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.18 isoniazid
kasA 2518439 c.325_327delGCCinsTG frameshift_variant&missense_variant 0.17 isoniazid
kasA 2518444 c.330T>C synonymous_variant 0.17 isoniazid
kasA 2518447 c.333T>G synonymous_variant 0.16 isoniazid
kasA 2518459 c.345T>C synonymous_variant 0.24 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.25 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.29 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.32 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.32 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.32 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.3 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.3 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.3 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.28 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.27 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.18 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.18 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.17 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.16 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.17 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.17 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.19 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.17 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.19 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.21 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.19 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.18 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.18 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.2 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.19 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.19 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.23 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.21 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.22 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.32 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.32 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.33 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.34 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.34 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.33 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.3 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.3 isoniazid
ahpC 2726258 c.66C>T synonymous_variant 0.15 isoniazid Not assoc w R - Interim
ahpC 2726303 c.111T>C synonymous_variant 0.22 isoniazid
ahpC 2726311 p.Ser40Asn missense_variant 0.2 isoniazid
ahpC 2726315 p.Asp41Glu missense_variant 0.18 isoniazid
ahpC 2726318 p.Glu42Asp missense_variant 0.19 isoniazid
ahpC 2726322 c.130_132delCCAinsGC frameshift_variant&missense_variant 0.18 isoniazid Uncertain significance
ahpC 2726330 c.138G>A synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ahpC 2726336 c.144G>C synonymous_variant 0.18 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.17 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ahpC 2726638 p.Ala149Val missense_variant 0.29 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.28 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.23 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.21 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ahpC 2726693 c.501C>G synonymous_variant 0.22 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.22 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.15 isoniazid
folC 2747264 p.Gly112Ala missense_variant 0.17 para-aminosalicylic_acid
folC 2747266 c.333C>T synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.17 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747302 c.297A>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.17 para-aminosalicylic_acid
Rv2477c 2782450 c.1593C>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782513 c.1530G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782525 c.1518C>T synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782822 c.1221G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782828 c.1215T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.37 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.35 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783179 c.864G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783209 c.834G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3065013 c.1179G>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065018 p.Asn392His missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1162_1164delGTGinsAC frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065040 c.1152C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065052 c.1140G>A synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065055 c.1137T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065915 c.277C>T synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065925 p.Ala89Gly missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065928 c.264G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065946 p.Gly82Ala missense_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066074 c.118C>T synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066078 c.114C>T synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066102 c.90C>T synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066118 p.Asn25Ser missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066582 c.-392_-391delCCinsGG upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067295 c.651C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067376 c.570G>A synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.34 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.47 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.47 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.47 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.39 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.33 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.35 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.3 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.27 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.29 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.32 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067736 c.208_210delTTCinsCT frameshift_variant&missense_variant 0.23 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.19 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.21 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.32 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.27 para-aminosalicylic_acid
thyA 3073836 c.636C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.22 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.27 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.21 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.2 para-aminosalicylic_acid
lpqB 3624050 c.861C>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624077 c.834G>A synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624143 c.768T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624185 c.726C>T synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624194 c.717C>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624200 c.711A>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624204 p.Ser236Asn missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624673 p.Ala80Ser missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624674 c.237C>T synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624680 c.231T>A synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.19 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.34 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.3 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624776 c.135T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624783 p.Ser43Thr missense_variant 0.16 bedaquiline
rifampicin
lpqB 3625099 c.-189C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625549 c.-639G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.21 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.24 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.27 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.23 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.3 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626723 c.627C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.23 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.24 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.15 bedaquiline
rifampicin
mtrA 3627917 c.-568G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
alr 3840618 p.Asp268Gly missense_variant 1.0 cycloserine
rpoA 3877494 p.Glu338Asp missense_variant 0.19 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.22 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.22 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.25 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.31 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.35 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.26 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.26 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.26 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.23 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.23 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.24 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.25 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.28 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.3 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.29 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.28 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.29 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.32 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.28 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.2 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878055 c.453A>G synonymous_variant 0.16 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.16 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.17 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878181 c.327C>T synonymous_variant 0.17 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.17 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.18 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.2 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.22 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.2 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.18 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.16 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.22 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.23 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.25 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.25 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.25 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.22 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.21 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.21 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.18 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.19 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.21 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.21 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.2 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.19 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.16 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.16 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.18 rifampicin
rpoA 3878683 c.-176G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.29 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.31 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.31 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.33 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.34 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.32 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.29 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.28 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.22 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.24 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.24 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.29 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.22 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.27 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.31 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.25 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.18 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.19 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.17 rifampicin
clpC1 4038293 c.2412G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.28 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.21 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.18 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.17 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.18 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.21 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.32 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.33 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.31 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.31 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.29 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.35 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.38 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.44 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.41 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.46 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.4 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.37 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.19 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.39 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.39 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.41 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.35 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.34 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.43 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.45 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.2 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.24 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.37 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.28 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.28 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.28 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.3 pyrazinamide
clpC1 4040501 c.204C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
panD 4044758 c.-477C>T upstream_gene_variant 0.17 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.16 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.23 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.22 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.2 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.18 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.17 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.16 pyrazinamide
glpK 4138695 p.Pro354His missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139126 c.630G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139137 p.Asp207Asn missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139143 c.613T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.573T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139195 c.561G>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139198 c.558C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139207 c.549T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.2 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139611 p.Ile49Val missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240685 p.Thr275Ala missense_variant 0.18 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.2 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.3 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.29 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.27 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.21 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.21 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.2 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.19 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.2 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.21 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.22 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.22 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.24 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.26 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.27 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.31 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.26 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.25 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.25 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.26 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.2 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241218 c.1356G>C synonymous_variant 0.16 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.18 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.17 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.2 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.2 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.22 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.19 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.18 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.18 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.18 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.22 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>A synonymous_variant 0.23 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.2 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.21 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.2 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.21 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.25 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.26 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.26 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.26 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.28 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.29 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.24 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.23 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.19 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.19 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.17 ethambutol
embC 4241648 c.1786_1788delTTGinsCC frameshift_variant&missense_variant 0.2 ethambutol
embC 4241657 p.Ser599Pro missense_variant 0.17 ethambutol
embC 4241719 c.1857G>C synonymous_variant 0.15 ethambutol
embC 4241727 p.Phe622Tyr missense_variant 0.17 ethambutol
embC 4241743 c.1881C>G synonymous_variant 0.17 ethambutol
embC 4241750 p.Leu630Val missense_variant 0.17 ethambutol
embC 4241770 c.1908T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241797 c.1935C>T synonymous_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242742 c.-491C>G upstream_gene_variant 0.17 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.18 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.19 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.19 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.19 ethambutol
embC 4242791 p.Ala977Ser missense_variant 0.17 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.19 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.2 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.21 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.22 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.26 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.27 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.26 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.26 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.26 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.25 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.24 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.24 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.25 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.2 ethambutol
embB 4245701 c.-813G>C upstream_gene_variant 0.18 ethambutol
embB 4245704 c.-810G>C upstream_gene_variant 0.18 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.2 ethambutol
embB 4245726 c.-788T>C upstream_gene_variant 0.2 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.2 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.19 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.15 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.16 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.15 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.18 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.18 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.3 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.3 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.3 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.31 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.33 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.33 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.35 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.29 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.32 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.3 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.29 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.19 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.19 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.2 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.21 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.22 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.22 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.23 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.22 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.23 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.24 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.24 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.23 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.23 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.27 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.28 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.29 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.25 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.2 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.19 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.18 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.17 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.17 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.2 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.18 ethambutol
embB 4248407 p.Leu632Val missense_variant 0.17 ethambutol
embB 4248419 p.Leu636Met missense_variant 0.16 ethambutol
embB 4248457 c.1944T>C synonymous_variant 0.18 ethambutol
embB 4249732 c.3219C>G synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267604 c.1233C>G synonymous_variant 0.16 ethambutol
aftB 4267607 c.1230G>A synonymous_variant 0.17 ethambutol
aftB 4267622 c.1215G>C synonymous_variant 0.17 ethambutol
aftB 4267625 c.1212T>C synonymous_variant 0.17 ethambutol
aftB 4267628 c.1209C>G synonymous_variant 0.17 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.18 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.21 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.2 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.19 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.18 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.18 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.17 ethambutol
ubiA 4269933 c.-100C>G upstream_gene_variant 1.0 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R