TB-Profiler result

Run: SRR10808668
Summary

Run ID: SRR10808668

Sample name:

Date: 2024-10-03T20:27:08.680446

Number of reads: 1840427

Percentage reads mapped: 65.7

Median coverage: 59.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.99
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.98
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5150 c.-90G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6181 c.942C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7153 c.-149G>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7198 c.1959C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7706 c.405C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7728 c.427A>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7745 c.444G>A synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7754 p.Asp151Glu missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7853 c.552C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8246 c.945C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8247 p.Ile316Val missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8273 c.972C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8492 c.1191G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8873 c.1572A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Thr missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9314 c.2013G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
fgd1 491490 c.708C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491499 c.717G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491508 c.726A>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491509 c.727T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Glu missense_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491526 c.744T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491548 p.Ala256Pro missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491563 c.781_783delAGCinsTCG synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491574 c.792C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575756 c.409C>T synonymous_variant 0.15 isoniazid
ethionamide
mshA 575772 p.Val142Ala missense_variant 0.15 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.15 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.98 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620724 c.834C>T synonymous_variant 0.17 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734499 c.246G>C synonymous_variant 0.17 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.15 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760139 c.333A>T synonymous_variant 0.15 rifampicin
rpoB 760142 c.336C>G synonymous_variant 0.16 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.2 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.19 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.19 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>T synonymous_variant 0.26 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.26 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.26 rifampicin
rpoB 760355 p.Glu183Asp missense_variant 0.26 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.26 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.25 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.23 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.22 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760451 c.645C>A synonymous_variant 0.16 rifampicin
rpoB 760457 c.651C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.15 rifampicin
rpoB 760499 c.693G>C synonymous_variant 0.16 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760535 c.729C>G synonymous_variant 0.16 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.25 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.25 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.25 rifampicin
rpoB 760755 p.His317Asn missense_variant 0.21 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.21 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.23 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.24 rifampicin
rpoB 760784 c.978G>C synonymous_variant 0.27 rifampicin
rpoB 760787 c.981G>C synonymous_variant 0.26 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.29 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.29 rifampicin
rpoB 760808 c.1002C>G synonymous_variant 0.27 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.26 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.26 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760829 c.1023C>T synonymous_variant 0.28 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.2 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.2 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.19 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.19 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.25 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.25 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761217 p.Pro471Ser missense_variant 0.23 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.24 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.2 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.19 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761361 c.1555_1556delAGinsTC synonymous_variant 0.19 rifampicin
rpoB 761367 p.Glu521Gln missense_variant 0.21 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.2 rifampicin
rpoB 761408 c.1602G>T synonymous_variant 0.16 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.16 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.13 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.17 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.16 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.15 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.15 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.14 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.27 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.28 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.26 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.24 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.22 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.2 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.14 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.15 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 0.18 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.2 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.19 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.16 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.17 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.17 rifampicin
rpoB 762353 c.2547C>T synonymous_variant 0.17 rifampicin
rpoB 762359 c.2553C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762362 p.Glu852Asp missense_variant 0.17 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.16 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.16 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.14 rifampicin
rpoB 762926 c.3120C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763049 c.-321G>A upstream_gene_variant 0.34 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.35 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763109 c.-261C>G upstream_gene_variant 0.29 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.27 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.27 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.3 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.3 rifampicin
rpoC 763193 c.-177C>T upstream_gene_variant 0.29 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.21 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.21 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 0.21 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.2 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.17 rifampicin
rpoC 763232 c.-138C>T upstream_gene_variant 0.17 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.17 rifampicin
rpoB 763241 p.Glu1145Asp missense_variant 0.17 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.24 rifampicin
rpoC 763492 c.123G>T synonymous_variant 0.26 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.36 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.42 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.41 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.39 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.36 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.28 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.26 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.3 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763811 p.Leu148Val missense_variant 0.27 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.21 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.25 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.28 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.25 rifampicin
rpoC 763867 c.498C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763871 p.Gly168Ser missense_variant 0.26 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.25 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.25 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.26 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.26 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.27 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.27 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.26 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.25 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.23 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.25 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.16 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.13 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.15 rifampicin Uncertain significance
rpoC 764213 c.844C>A synonymous_variant 0.14 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.21 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.19 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.19 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.18 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.21 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.18 rifampicin
rpoC 764311 c.942C>G synonymous_variant 0.16 rifampicin
rpoC 764341 c.972G>T synonymous_variant 0.27 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.28 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.34 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.27 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.24 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.24 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.24 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.23 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.27 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.22 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764671 c.1302G>C synonymous_variant 0.31 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.35 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.28 rifampicin
rpoC 764878 c.1509C>T synonymous_variant 0.25 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.27 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.26 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.22 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765376 c.2007C>T synonymous_variant 0.18 rifampicin
rpoC 765379 c.2010G>C synonymous_variant 0.18 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.18 rifampicin Uncertain significance
rpoC 765404 p.Leu679Lys missense_variant 0.24 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.21 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.22 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.24 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.26 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.29 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.27 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.22 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.14 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.17 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.26 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.26 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.28 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.3 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.31 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766456 c.3087C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766459 c.3090G>T synonymous_variant 0.21 rifampicin
rpoC 766483 c.3114G>T synonymous_variant 0.2 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.2 rifampicin Uncertain significance
rpoC 766492 c.3123T>G synonymous_variant 0.2 rifampicin
rpoC 766493 p.Gly1042Asn missense_variant 0.2 rifampicin
rpoC 766504 c.3135G>C synonymous_variant 0.21 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.16 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.17 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.17 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.15 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.15 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.15 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.15 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.15 rifampicin
rpoC 766732 c.3363G>T synonymous_variant 0.16 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.16 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.16 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.17 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.16 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.17 rifampicin
rpoC 766780 c.3411G>A synonymous_variant 0.18 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766876 c.3507C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 766895 c.3526T>C synonymous_variant 0.16 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.16 rifampicin
rpoC 766909 c.3540G>C synonymous_variant 0.16 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.16 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.17 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.2 rifampicin
rpoC 766931 p.Ala1188Thr missense_variant 0.2 rifampicin Uncertain significance
rpoC 766942 c.3573C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766948 c.3579G>C synonymous_variant 0.23 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767068 c.3699G>C synonymous_variant 0.3 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 0.25 rifampicin Uncertain significance
rpoC 767158 c.3789T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775817 c.2664T>C synonymous_variant 0.18 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
mmpL5 775856 c.2625T>C synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 775904 c.2577G>A synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 775915 p.Ala856Ser missense_variant 0.16 bedaquiline
clofazimine
mmpL5 775916 c.2565T>C synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 775937 c.2544G>T synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781751 c.192G>C synonymous_variant 0.15 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.16 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.18 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.21 streptomycin Not assoc w R - Interim
rpsL 781811 c.252C>T synonymous_variant 0.23 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.23 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.24 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.24 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.23 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.23 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.22 streptomycin
rpsL 781853 c.294C>T synonymous_variant 0.24 streptomycin
rpsL 781859 c.300T>A synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.25 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.25 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.31 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.3 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.27 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.26 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.26 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 800633 c.-176T>C upstream_gene_variant 0.17 linezolid
rplC 800642 c.-167C>T upstream_gene_variant 0.18 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1304490 c.1560C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304499 c.1569T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1304515 p.Ala529Thr missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304553 c.1623C>A synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304556 c.1626C>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304562 c.1632G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304571 c.1641G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304637 c.1707G>A synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
sigE 1364839 c.427T>C synonymous_variant 0.15 pyrazinamide
sigE 1364859 c.447C>T synonymous_variant 0.16 pyrazinamide
sigE 1364865 c.453G>T synonymous_variant 0.15 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.15 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.14 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472032 n.187G>T non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472041 n.196C>G non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>A non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473811 n.154C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473833 n.176G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473935 n.278C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474096 n.439C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474101 n.446_450delAGTAT non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474108 n.451C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474110 n.454_455insGGTGT non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_635delTCCTTTinsCTCGACTTG non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474716 n.1059_1063delAAAGCinsCCAAGAAT non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475353 n.1696A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475354 n.1697A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475378 n.1721A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475379 n.1722G>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475387 n.1730C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475398 n.1741C>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475399 n.1742T>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475618 n.1961C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476031 n.2374_2378delCCTCGinsTTCAC non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.58 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
inhA 1673547 c.-655T>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673556 c.-646C>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673580 c.-622T>C upstream_gene_variant 0.24 isoniazid Uncertain significance
ethionamide
inhA 1673595 c.-607A>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673596 c.-606_-604delAAGinsGAC upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673607 c.-595T>C upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673615 c.-587_-586delAAinsTG upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673619 c.-583T>C upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673633 c.-569G>A upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673637 c.-565C>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673646 c.-556T>C upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673652 c.-550C>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673657 c.-545_-544delCGinsAA upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673660 c.-542C>A upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673664 c.-538A>C upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673691 c.-511G>T upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673709 c.-493C>T upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673710 c.-492_-490delCTAinsATC upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673716 c.-486_-485delGCinsCA upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673721 c.-481C>T upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673724 c.-478A>G upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673730 c.-472C>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673749 c.-453_-452delAAinsCG upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673760 c.-442G>C upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673772 c.-430C>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673799 c.-403T>G upstream_gene_variant 0.15 isoniazid
ethionamide
inhA 1673802 c.-400A>G upstream_gene_variant 0.15 isoniazid
ethionamide
inhA 1674489 c.288G>T synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674514 p.Ile105Val missense_variant 0.16 isoniazid
ethionamide
rpsA 1833634 c.93G>A synonymous_variant 0.14 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.19 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.28 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.29 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.32 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.29 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833877 c.336C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.31 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.27 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.27 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.26 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834190 c.649_650delTCinsAG synonymous_variant 0.2 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834228 c.687C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>T synonymous_variant 0.3 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.27 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.23 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834732 c.1191T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.18 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.17 pyrazinamide
rpsA 1834774 c.1233C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.15 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.15 pyrazinamide
tsnR 1853417 c.-189G>C upstream_gene_variant 0.15 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.16 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.2 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.21 linezolid
tsnR 1853441 c.-165C>A upstream_gene_variant 0.22 linezolid
tsnR 1853453 c.-153G>C upstream_gene_variant 0.2 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.18 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.18 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.16 linezolid
tsnR 1853523 c.-83_-82delCGinsAA upstream_gene_variant 0.15 linezolid
tsnR 1853531 c.-75A>C upstream_gene_variant 0.16 linezolid
tsnR 1853537 c.-69C>T upstream_gene_variant 0.17 linezolid
tsnR 1853540 c.-66A>G upstream_gene_variant 0.17 linezolid
tsnR 1853552 c.-54C>G upstream_gene_variant 0.18 linezolid
tsnR 1853561 c.-45G>A upstream_gene_variant 0.17 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.16 isoniazid
Rv2477c 2783584 p.Ala153Pro missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783596 c.447C>T synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783602 c.441G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
ribD 2987049 p.Phe71Val missense_variant 1.0 para-aminosalicylic_acid
Rv2752c 3065058 c.1134C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065061 c.1131C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065064 c.1128G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065070 c.1122C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065085 c.1105_1107delAGGinsCGC synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065088 c.1104A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065097 c.1095C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065106 c.1086C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065109 c.1081_1083delAGAinsCGG synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065126 p.Ser356Ala missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065130 c.1062A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065133 c.1059T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625222 c.1392T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625240 c.-330T>C upstream_gene_variant 0.15 rifampicin
bedaquiline
lpqB 3625258 c.-348G>T upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3625267 c.1347T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625270 c.-360G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625279 c.-369C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625285 c.-375G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625291 c.-381A>G upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625312 c.-402G>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625325 p.His430Arg missense_variant 0.16 rifampicin
bedaquiline
lpqB 3625345 c.-435T>C upstream_gene_variant 0.15 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625741 c.-831G>A upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625753 p.Ala287Gln missense_variant 0.16 rifampicin
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3877593 c.915C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877602 c.906C>T synonymous_variant 0.17 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.18 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.18 rifampicin
rpoA 3877695 c.813C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877734 c.774G>C synonymous_variant 0.15 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.17 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877770 c.735_738delGTCAinsCAGC synonymous_variant 0.17 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.19 rifampicin
rpoA 3877803 c.705G>C synonymous_variant 0.2 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.15 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>C synonymous_variant 0.15 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.14 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.17 rifampicin
rpoA 3878130 c.378C>A synonymous_variant 0.17 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.17 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.26 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.29 rifampicin
rpoA 3878262 p.Ser82Gly missense_variant 0.28 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.27 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
clpC1 4038499 p.Ser736Gly missense_variant 0.17 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.16 pyrazinamide
clpC1 4038534 p.Arg724His missense_variant 0.14 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.2 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.19 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039070 c.1635G>T synonymous_variant 0.15 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.21 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039265 c.1440C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.24 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039319 p.Ala462Gly missense_variant 0.21 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039328 c.1377A>T synonymous_variant 0.22 pyrazinamide
clpC1 4039337 c.1368A>C synonymous_variant 0.22 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039472 c.1233G>T synonymous_variant 0.15 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.19 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039616 c.1089G>T synonymous_variant 0.21 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039991 c.714G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040303 c.402G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040495 c.210C>A synonymous_variant 0.14 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.16 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040594 c.111G>T synonymous_variant 0.16 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.14 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.14 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.17 pyrazinamide
glpK 4138676 c.1080T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.14 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138787 c.969C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138796 c.960A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138802 c.954G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138808 c.948G>T synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138823 c.933G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138847 c.909A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138853 c.903C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138859 p.Asn299Glu missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138875 p.Thr294Lys missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138877 c.879A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240816 c.954C>A synonymous_variant 0.15 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.14 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248118 c.1605T>C synonymous_variant 0.15 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.14 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.15 ethambutol
embB 4248143 p.Leu544Ile missense_variant 0.15 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248158 p.Cys549Ser missense_variant 0.16 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.18 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.18 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.18 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.22 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.21 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248225 p.Ala571Val missense_variant 0.19 ethambutol Uncertain significance
embB 4248252 p.Gly580Ala missense_variant 0.15 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R