TB-Profiler result

Run: SRR9971113
Summary

Run ID: SRR9971113

Sample name:

Date: 2025-02-11T17:52:00.683175

Number of reads: 6515034

Percentage reads mapped: 41.43

Median coverage: 174.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.55 amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.46 amikacin Assoc w R
capreomycin Assoc w R
kanamycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7472 c.171T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575734 c.387T>G synonymous_variant 0.13 isoniazid
ethionamide
mshA 575744 p.Ala133Thr missense_variant 0.13 isoniazid Uncertain significance
ethionamide
mshA 575749 c.402C>A synonymous_variant 0.14 isoniazid
ethionamide
mshA 575764 c.417C>G synonymous_variant 0.14 isoniazid
ethionamide
mshA 575771 p.Val142Ile missense_variant 0.13 isoniazid
ethionamide
mshA 575776 c.429C>T synonymous_variant 0.13 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.13 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.13 isoniazid
ethionamide
mshA 575795 p.Ile150Val missense_variant 0.12 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.94 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 760184 c.378A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.13 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.13 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.16 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.16 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.17 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760407 p.Ser201Gly missense_variant 0.13 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.22 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.13 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.15 rifampicin
rpoB 761289 p.Ser495Ala missense_variant 0.13 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.14 rifampicin
rpoB 761375 c.1569G>C synonymous_variant 0.13 rifampicin
rpoB 761648 c.1842T>C synonymous_variant 0.15 rifampicin
rpoB 762030 p.Thr742Ser missense_variant 0.12 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.13 rifampicin Uncertain significance
rpoB 762065 c.2259T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.2 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762084 p.Ala760Pro missense_variant 0.19 rifampicin
rpoB 762098 c.2292C>G synonymous_variant 0.26 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.36 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.26 rifampicin
rpoB 762125 p.Glu773Asp missense_variant 0.26 rifampicin
rpoB 762128 c.2322G>C synonymous_variant 0.26 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.37 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.38 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.38 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.3 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762177 p.Arg791Gly missense_variant 0.26 rifampicin
rpoB 762181 p.Asp792Ala missense_variant 0.26 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762189 p.Ile795Val missense_variant 0.27 rifampicin
rpoB 762209 c.2403C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.23 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762248 c.2442G>C synonymous_variant 0.14 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.13 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.19 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.16 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.16 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.14 rifampicin
rpoB 762350 c.2544C>T synonymous_variant 0.14 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.14 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.14 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.15 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.13 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.13 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.14 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.12 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.15 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>A synonymous_variant 0.24 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.25 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.29 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.27 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.27 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.27 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.38 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.33 rifampicin Uncertain significance
rpoC 763633 c.264T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.14 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763686 p.Tyr106Phe missense_variant 0.29 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.21 rifampicin
rpoC 763709 p.Leu114Phe missense_variant 0.18 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.39 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.2 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.16 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.17 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.15 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.17 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.12 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.14 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.16 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.17 rifampicin
rpoC 764263 c.894G>T synonymous_variant 0.16 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.16 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.18 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.19 rifampicin
rpoC 764338 p.Glu323Asp missense_variant 0.2 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.2 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.21 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.23 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGT synonymous_variant 0.31 rifampicin
rpoC 764440 c.1071G>C synonymous_variant 0.24 rifampicin
rpoC 764441 p.Ile358Leu missense_variant 0.24 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.32 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>C synonymous_variant 0.27 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.22 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.27 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 0.32 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.41 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.44 rifampicin
rpoC 764573 p.Leu402Ile missense_variant 0.44 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.42 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.42 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.43 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.46 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.52 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.35 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Gln missense_variant 0.34 rifampicin Uncertain significance
rpoC 764716 c.1347G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764737 c.1368G>C synonymous_variant 0.39 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.39 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.36 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764785 c.1416C>G synonymous_variant 0.34 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.31 rifampicin
rpoC 764801 c.1433_1434insTG frameshift_variant 0.31 rifampicin
rpoC 764804 c.1436_1437delAG frameshift_variant 0.27 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.26 rifampicin
rpoC 764813 p.Gln482Val missense_variant 0.26 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764843 p.Ala492Thr missense_variant 0.24 rifampicin
rpoC 764854 c.1485G>C synonymous_variant 0.21 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.2 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.16 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.17 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.19 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.18 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.17 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.17 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.17 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.17 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 0.14 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767163 p.Asn1265Thr missense_variant 0.12 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.13 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.13 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775904 c.2577G>A synonymous_variant 0.13 bedaquiline
clofazimine
mmpL5 775951 c.2530C>T synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781709 c.150G>C synonymous_variant 0.13 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.13 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.13 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.13 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.13 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.14 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.13 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.14 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.15 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.13 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.14 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.14 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.13 streptomycin Uncertain significance
rplC 800570 c.-239C>G upstream_gene_variant 0.15 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.15 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.15 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.15 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.15 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.15 linezolid
rplC 800603 c.-206G>C upstream_gene_variant 0.15 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.16 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.14 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.15 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.15 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.14 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.14 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472434 n.589_590insC non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472437 n.592T>G non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472438 n.594delC non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>A non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472461 n.616G>T non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472467 n.622G>T non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472469 n.625_626insATC non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472473 n.629_631delCGA non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472583 n.738T>C non_coding_transcript_exon_variant 0.48 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.49 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472674 n.829T>C non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472685 n.840G>A non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472701 n.856T>A non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472912 n.1067C>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472917 n.1072G>A non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.64 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473002 n.1157G>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.14 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473008 n.1163C>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473009 n.1164T>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276_1277delTTinsCA non_coding_transcript_exon_variant 0.68 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.56 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473288 n.1443_1444delCTinsGTTCG non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473293 n.1449delA non_coding_transcript_exon_variant 0.49 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.45 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.49 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473750 n.93C>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473782 n.125A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473788 n.131A>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473797 n.140G>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473845 n.188G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1474096 n.439C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474108 n.451C>G non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474280 n.623C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474292 n.635_650delTTCCTCTCCGGAGGAGinsGGCT non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474309 n.653delT non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474317 n.660G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474355 n.698A>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474356 n.699T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474381 n.724T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474476 n.819C>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474528 n.871T>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474529 n.872A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474541 n.884G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053delT non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474714 n.1058delT non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.7 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404delC non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475068 n.1411A>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475078 n.1421T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475174 n.1517C>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475176 n.1519G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475604 n.1950_1951delAT non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475608 n.1951T>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475621 n.1964T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475634 n.1977_1981delGGATCinsTGGA non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475752 n.2095C>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.4 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.4 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.58 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.47 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833676 c.135A>G synonymous_variant 0.13 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.12 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.16 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1833790 c.249T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.15 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833893 p.Ala118Lys missense_variant 0.2 pyrazinamide
rpsA 1833896 p.Leu119Ile missense_variant 0.2 pyrazinamide
rpsA 1833905 p.Lys122Glu missense_variant 0.2 pyrazinamide
rpsA 1833912 p.Glu124Gly missense_variant 0.2 pyrazinamide
rpsA 1833915 p.Ala125Val missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833921 p.Lys127Thr missense_variant 0.21 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.21 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834234 c.693G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.21 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834307 p.Asp256Gln missense_variant 0.22 pyrazinamide
rpsA 1834318 c.777C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834327 c.786G>T synonymous_variant 0.21 pyrazinamide
rpsA 1834330 c.789C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834340 p.Met267Phe missense_variant 0.16 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.13 pyrazinamide
rpsA 1834378 c.837T>G synonymous_variant 0.13 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.13 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.12 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.12 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834802 p.Ala421Thr missense_variant 0.95 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
folC 2747167 p.Lys144Asn missense_variant 0.99 para-aminosalicylic_acid
ald 3086739 c.-81G>A upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3877704 c.804G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.14 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.15 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.17 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.17 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.16 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.17 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.16 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>A synonymous_variant 0.16 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.15 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.13 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039295 c.1410A>C synonymous_variant 0.12 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.12 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.12 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039577 c.1128T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039592 c.1113G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039711 p.Ile332Val missense_variant 0.14 pyrazinamide
clpC1 4039714 p.Tyr331His missense_variant 0.15 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
glpK 4138747 c.1009C>T synonymous_variant 0.12 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R