Run ID: SRR14802079
Sample name:
Date: 2024-04-15T03:00:48.836855
Number of reads: 2193723
Percentage reads mapped: 62.68
Median coverage: 66.0
Strain: lineage4.2.1
Spoligotype:
Drug-resistance: MDR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.2 | Euro-American | None | 0.96 |
lineage4 | Euro-American | None | 1.0 |
lineage4.2.1 | Euro-American (TUR) | None | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Ser450Leu | Assoc w R | |
isoniazid | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
katG | p.Ser315Thr | Assoc w R | High-level resistance | |
ethambutol | embB | p.Ser297Ala | Uncertain significance | Mutation from literature |
pyrazinamide | pncA | c.195_*4836del | Assoc w R | |
streptomycin | rpsL | p.Lys88Arg | Assoc w R | |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | eis | c.-12C>T | Assoc w R | |
cycloserine | ||||
ethionamide | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T |
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | fbiC | c.1603_1605delTTGinsCA | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 0.69 | rifampicin | Assoc w R | |
rpsL | 781822 | p.Lys88Arg | missense_variant | 0.73 | streptomycin | Assoc w R | |
fbiC | 1304533 | c.1603_1605delTTGinsCA | frameshift_variant&missense_variant | 0.19 | pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
inhA | 1673425 | c.-777C>T | upstream_gene_variant | 0.97 | isoniazid | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
ethionamide | Assoc w R | Alias fabG1_c.-15C>T | |||||
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid | Assoc w R | High-level resistance |
pncA | 2283844 | c.195_*4836del | frameshift_variant&stop_lost&splice_region_variant | 0.98 | pyrazinamide | Assoc w R | |
eis | 2715344 | c.-12C>T | upstream_gene_variant | 0.96 | kanamycin | Assoc w R | |
embB | 4247402 | p.Ser297Ala | missense_variant | 0.95 | ethambutol | Uncertain significance | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 897 | c.897A>G | synonymous_variant | 0.15 | isoniazid | |
dnaA | 909 | c.909A>C | synonymous_variant | 0.14 | isoniazid | Not assoc w R - Interim |
dnaA | 912 | c.912T>G | synonymous_variant | 0.15 | isoniazid | |
dnaA | 915 | c.915C>T | synonymous_variant | 0.15 | isoniazid | |
dnaA | 918 | c.918C>G | synonymous_variant | 0.15 | isoniazid | |
dnaA | 921 | c.921A>G | synonymous_variant | 0.15 | isoniazid | Not assoc w R - Interim |
dnaA | 933 | c.933C>G | synonymous_variant | 0.14 | isoniazid | |
dnaA | 993 | c.993A>G | synonymous_variant | 0.13 | isoniazid | |
dnaA | 996 | c.996A>G | synonymous_variant | 0.13 | isoniazid | |
gyrA | 6676 | c.-626T>G | upstream_gene_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6700 | c.-602T>C | upstream_gene_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6703 | c.-599G>C | upstream_gene_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6706 | c.-596G>A | upstream_gene_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6709 | c.-593A>G | upstream_gene_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6712 | c.-590G>C | upstream_gene_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6778 | c.-524C>T | upstream_gene_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6793 | c.1554T>C | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6797 | p.Gly520Ser | missense_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7427 | c.126G>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7436 | c.135C>T | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7442 | c.141G>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7451 | c.150C>G | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7457 | c.156T>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7463 | c.162G>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7469 | c.168C>G | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7472 | c.171T>C | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7475 | c.174A>G | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7480 | p.Phe60Tyr | missense_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7484 | c.183T>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7490 | c.189C>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7496 | c.195C>G | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7499 | c.198G>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7502 | c.201C>T | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7523 | c.222C>G | synonymous_variant | 0.23 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7526 | c.225G>C | synonymous_variant | 0.23 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7532 | c.231T>G | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7541 | c.240C>G | synonymous_variant | 0.23 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7547 | c.246C>T | synonymous_variant | 0.22 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7553 | c.252C>T | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7565 | c.264C>T | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7569 | p.Ala90Ser | missense_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7616 | c.315G>T | synonymous_variant | 0.12 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7625 | c.324G>A | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7683 | c.382A>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7694 | c.393A>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7706 | c.405C>A | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7710 | c.409T>C | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7715 | c.414G>C | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7725 | c.424C>T | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7728 | c.427_429delAGGinsCC | frameshift_variant&missense_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7763 | c.462T>G | synonymous_variant | 0.42 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7778 | c.477G>C | synonymous_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7787 | c.486G>A | synonymous_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7790 | c.489G>C | synonymous_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7793 | c.492G>C | synonymous_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7796 | c.495G>C | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7799 | c.498A>G | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7802 | c.501C>G | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7832 | c.531G>T | synonymous_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7835 | c.534A>C | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7847 | c.546G>C | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7859 | c.558A>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7865 | c.564T>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7880 | c.579C>T | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7886 | c.585T>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8453 | c.1152A>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8459 | c.1158G>A | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8462 | c.1161A>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8471 | c.1170T>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8546 | p.Asp415Glu | missense_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8555 | c.1254G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8561 | c.1260A>G | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8619 | c.1318T>C | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8624 | c.1323G>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8630 | c.1329G>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8633 | c.1332C>A | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8636 | c.1335A>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8642 | c.1341A>G | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8649 | p.Arg450Lys | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8655 | p.Ile452Val | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8672 | c.1371A>G | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8693 | c.1392T>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8696 | c.1395G>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8699 | c.1398A>G | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8705 | c.1404C>T | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8711 | c.1410A>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8717 | c.1416C>G | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8720 | c.1419G>A | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8729 | c.1428T>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8731 | p.Gly477Ala | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8738 | c.1437G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8740 | p.Arg480His | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8750 | c.1449C>G | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8769 | p.His490Tyr | missense_variant | 0.16 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8777 | c.1476C>T | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8783 | c.1482G>T | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8786 | c.1485T>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8792 | c.1491G>A | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8796 | p.Ile499Val | missense_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8799 | p.Ala500Pro | missense_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8810 | c.1509A>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8813 | c.1512C>T | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 8825 | c.1524G>A | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8829 | c.1528T>C | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8840 | c.1539C>T | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8849 | c.1548C>G | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8852 | c.1551T>G | synonymous_variant | 0.22 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8858 | c.1557T>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8867 | c.1566A>G | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8897 | c.1596T>C | synonymous_variant | 0.22 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8900 | c.1599G>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8903 | c.1602T>C | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8915 | c.1614A>G | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8933 | c.1632G>T | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8939 | c.1638T>A | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8946 | c.1645T>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8952 | p.Gln551Ala | missense_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8967 | p.Ala556Asn | missense_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8981 | c.1680G>C | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8987 | c.1686C>G | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8996 | c.1695T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8998 | p.Leu566Trp | missense_variant | 0.24 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 9017 | c.1716C>G | synonymous_variant | 0.23 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9023 | c.1722A>C | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9029 | c.1728T>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9032 | c.1731T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
fgd1 | 491247 | c.465C>T | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
mshA | 575785 | c.438T>C | synonymous_variant | 0.14 | ethionamide | |
isoniazid | ||||||
mshA | 575795 | p.Ile150Val | missense_variant | 0.15 | ethionamide | |
isoniazid | ||||||
mshA | 575800 | c.453G>T | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
mshA | 575833 | c.486C>T | synonymous_variant | 0.17 | ethionamide | Not assoc w R - Interim |
isoniazid | Not assoc w R - Interim | |||||
mshA | 575842 | c.495G>C | synonymous_variant | 0.18 | ethionamide | |
isoniazid | ||||||
mshA | 575845 | c.498C>G | synonymous_variant | 0.18 | ethionamide | |
isoniazid | ||||||
mshA | 575864 | c.517T>C | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
mshA | 575878 | c.531A>G | synonymous_variant | 0.14 | ethionamide | |
isoniazid | ||||||
mshA | 575884 | c.537G>C | synonymous_variant | 0.14 | ethionamide | |
isoniazid | ||||||
ccsA | 619969 | p.Val27Ile | missense_variant | 0.96 | capreomycin | Not assoc w R - Interim |
amikacin | Not assoc w R | |||||
kanamycin | Uncertain significance | |||||
nusG | 734439 | c.186C>G | synonymous_variant | 0.15 | rifampicin | |
nusG | 734451 | c.198G>C | synonymous_variant | 0.2 | rifampicin | |
nusG | 734454 | c.201A>G | synonymous_variant | 0.2 | rifampicin | |
nusG | 734460 | c.207G>C | synonymous_variant | 0.21 | rifampicin | |
nusG | 734472 | c.219T>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
nusG | 734475 | c.222T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
nusG | 734499 | c.246G>C | synonymous_variant | 0.22 | rifampicin | |
nusG | 734532 | c.279A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
nusG | 734541 | c.288A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
nusG | 734559 | c.306T>C | synonymous_variant | 0.15 | rifampicin | |
nusG | 734571 | c.318C>G | synonymous_variant | 0.16 | rifampicin | |
nusG | 734580 | c.327T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 760139 | c.333A>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 760142 | c.336C>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760181 | c.375T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760223 | c.417T>C | synonymous_variant | 0.21 | rifampicin | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760244 | c.438G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760256 | c.450C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760298 | c.492G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760310 | c.504G>C | synonymous_variant | 0.26 | rifampicin | |
rpoB | 760316 | c.510C>G | synonymous_variant | 0.26 | rifampicin | |
rpoB | 760331 | c.525G>T | synonymous_variant | 0.28 | rifampicin | |
rpoB | 760334 | c.528G>A | synonymous_variant | 0.27 | rifampicin | |
rpoB | 760340 | c.534G>T | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 760357 | p.Thr184Ser | missense_variant | 0.22 | rifampicin | Uncertain significance |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.23 | rifampicin | Uncertain significance |
rpoB | 760406 | c.600G>C | synonymous_variant | 0.3 | rifampicin | |
rpoB | 760407 | p.Ser201Gly | missense_variant | 0.3 | rifampicin | Uncertain significance |
rpoB | 760415 | c.609C>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 760424 | c.618C>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 760460 | c.654G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760463 | c.657C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760475 | c.669A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760478 | c.672C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760481 | c.675G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760484 | c.678A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760502 | c.696C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760522 | p.Ser239Asn | missense_variant | 0.22 | rifampicin | Uncertain significance |
rpoB | 760532 | c.726T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 760535 | c.729C>G | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760674 | c.868T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 760679 | c.873A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760683 | c.877T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760724 | c.918T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 760730 | c.924T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760748 | c.942C>G | synonymous_variant | 0.31 | rifampicin | |
rpoB | 760751 | c.945G>C | synonymous_variant | 0.31 | rifampicin | |
rpoB | 760755 | c.949_951delCATinsAC | frameshift_variant&missense_variant | 0.31 | rifampicin | |
rpoB | 760759 | p.Val318Ala | missense_variant | 0.33 | rifampicin | |
rpoB | 760764 | p.Glu320Gln | missense_variant | 0.37 | rifampicin | |
rpoB | 760769 | c.963C>G | synonymous_variant | 0.38 | rifampicin | |
rpoB | 760778 | c.972G>C | synonymous_variant | 0.38 | rifampicin | |
rpoB | 760784 | c.978G>C | synonymous_variant | 0.36 | rifampicin | |
rpoB | 760793 | c.987A>G | synonymous_variant | 0.36 | rifampicin | |
rpoB | 760805 | c.999G>C | synonymous_variant | 0.39 | rifampicin | |
rpoB | 760817 | c.1011A>G | synonymous_variant | 0.35 | rifampicin | |
rpoB | 760820 | c.1014T>C | synonymous_variant | 0.34 | rifampicin | |
rpoB | 760826 | c.1020C>G | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760829 | c.1023C>T | synonymous_variant | 0.32 | rifampicin | |
rpoB | 760830 | c.1024T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 760841 | c.1035T>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760848 | p.Thr348Ser | missense_variant | 0.27 | rifampicin | |
rpoB | 760856 | c.1050C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760862 | c.1056G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760985 | c.1179G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760988 | c.1182C>G | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760991 | c.1185G>T | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760997 | c.1191G>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 761015 | c.1209G>C | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoB | 761027 | c.1221A>G | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoB | 761036 | c.1230G>C | synonymous_variant | 0.65 | rifampicin | Not assoc w R - Interim |
rpoB | 761037 | c.1231T>C | synonymous_variant | 0.63 | rifampicin | Not assoc w R - Interim |
rpoB | 761051 | c.1245G>T | synonymous_variant | 0.78 | rifampicin | Not assoc w R - Interim |
rpoB | 761054 | c.1248G>C | synonymous_variant | 0.78 | rifampicin | Not assoc w R - Interim |
rpoB | 761057 | c.1251G>C | synonymous_variant | 0.78 | rifampicin | Not assoc w R - Interim |
rpoB | 761060 | c.1254C>G | synonymous_variant | 0.78 | rifampicin | Not assoc w R - Interim |
rpoB | 761063 | c.1257C>G | synonymous_variant | 0.78 | rifampicin | Not assoc w R - Interim |
rpoB | 761084 | c.1278C>G | synonymous_variant | 0.61 | rifampicin | |
rpoB | 761097 | c.1291_1293delAGCinsTCG | synonymous_variant | 0.53 | rifampicin | |
rpoB | 761102 | c.1296A>G | synonymous_variant | 0.53 | rifampicin | |
rpoB | 761123 | c.1317G>C | synonymous_variant | 0.4 | rifampicin | |
rpoB | 761126 | c.1320G>T | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoB | 761132 | c.1326G>T | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoB | 761133 | c.1327T>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoB | 761147 | c.1341C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 761150 | c.1344A>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 761165 | c.1359G>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 761171 | c.1365C>T | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoB | 761180 | c.1374A>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 761195 | c.1389G>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 761198 | c.1392G>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 761217 | c.1411_1413delCCGinsTC | frameshift_variant&missense_variant | 0.28 | rifampicin | |
rpoB | 761220 | c.1414_1416delTCGinsAGC | synonymous_variant | 0.28 | rifampicin | |
rpoB | 761234 | c.1428G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 761249 | c.1443A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 761264 | c.1458C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 761300 | c.1494G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 761636 | c.1830G>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761645 | c.1839C>A | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761648 | c.1842T>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761657 | c.1851C>A | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761660 | c.1854G>A | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761666 | c.1860G>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761669 | c.1863C>T | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761675 | c.1869G>C | synonymous_variant | 0.15 | rifampicin | |
rpoB | 761930 | c.2124G>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761969 | c.2163G>A | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 761999 | c.2193G>C | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762000 | c.2194_2195delTCinsAG | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762014 | c.2208C>T | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762038 | c.2232C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762047 | c.2241G>A | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762053 | c.2247T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 762065 | c.2259T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762101 | c.2295C>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoB | 762131 | c.2325C>G | synonymous_variant | 0.2 | rifampicin | |
rpoB | 762137 | c.2331C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 762140 | c.2334G>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 762143 | c.2337T>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 762149 | c.2343G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 762158 | c.2352G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762167 | c.2361T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762176 | c.2370T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 762209 | c.2403C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762218 | c.2412T>C | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762239 | c.2433G>A | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762245 | c.2439G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762284 | c.2478G>T | synonymous_variant | 0.24 | rifampicin | |
rpoB | 762293 | c.2487T>G | synonymous_variant | 0.25 | rifampicin | |
rpoB | 762299 | c.2493G>A | synonymous_variant | 0.24 | rifampicin | |
rpoB | 762308 | c.2502G>C | synonymous_variant | 0.21 | rifampicin | |
rpoB | 762314 | c.2508C>T | synonymous_variant | 0.23 | rifampicin | |
rpoB | 762317 | c.2511A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762329 | c.2523G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 762335 | c.2529C>T | synonymous_variant | 0.17 | rifampicin | |
rpoB | 762338 | c.2532T>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 762341 | c.2535G>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 762347 | c.2541T>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 762353 | c.2547C>T | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762362 | p.Glu852Asp | missense_variant | 0.24 | rifampicin | |
rpoB | 762369 | c.2563T>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 762395 | c.-975G>C | upstream_gene_variant | 0.26 | rifampicin | |
rpoC | 762398 | c.-972T>C | upstream_gene_variant | 0.26 | rifampicin | |
rpoB | 762404 | c.2598T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 762410 | c.2604T>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762416 | c.2610A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 762434 | c.-936T>C | upstream_gene_variant | 0.22 | rifampicin | |
rpoC | 762443 | c.-927G>C | upstream_gene_variant | 0.22 | rifampicin | |
rpoB | 762449 | c.2643C>A | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762452 | c.2646G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762470 | c.2664G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 762488 | c.2682G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 762489 | c.2683_2685delGTTinsAC | frameshift_variant&missense_variant | 0.19 | rifampicin | |
rpoB | 762857 | c.3051C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 762863 | c.3057T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 762878 | p.Ile1024Met | missense_variant | 0.22 | rifampicin | |
rpoB | 762879 | p.Met1025Leu | missense_variant | 0.22 | rifampicin | Uncertain significance |
rpoC | 762917 | c.-453C>T | upstream_gene_variant | 0.16 | rifampicin | |
rpoB | 762920 | c.3114C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 762989 | c.3183G>A | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 763004 | c.3198G>A | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 763007 | c.3201C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R |
rpoC | 763049 | c.-321G>A | upstream_gene_variant | 0.17 | rifampicin | |
rpoB | 763053 | c.3247T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 763085 | c.3279C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763109 | c.-261C>G | upstream_gene_variant | 0.21 | rifampicin | |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 763127 | c.3321G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 763130 | c.3324G>A | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 763133 | c.-237G>C | upstream_gene_variant | 0.2 | rifampicin | |
rpoB | 763136 | c.3330C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 763139 | c.-231C>T | upstream_gene_variant | 0.21 | rifampicin | |
rpoC | 763142 | c.-228C>A | upstream_gene_variant | 0.21 | rifampicin | |
rpoC | 763160 | c.-210G>T | upstream_gene_variant | 0.24 | rifampicin | |
rpoB | 763166 | c.3360A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 763169 | c.-201A>G | upstream_gene_variant | 0.2 | rifampicin | |
rpoC | 763193 | c.-177C>T | upstream_gene_variant | 0.15 | rifampicin | |
rpoC | 763411 | c.42T>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763414 | c.45T>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763468 | c.99G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 763573 | c.204G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763618 | c.249C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763642 | c.273G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 763660 | c.291T>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763666 | c.297G>A | synonymous_variant | 0.18 | rifampicin | |
rpoC | 763675 | c.306C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764153 | p.Gln262Lys | missense_variant | 0.13 | rifampicin | |
rpoC | 764227 | c.858G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764239 | c.870T>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764254 | c.885G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764257 | c.888G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764263 | c.894G>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764266 | c.897T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764272 | c.903G>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764278 | c.909A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764287 | c.918C>T | synonymous_variant | 0.25 | rifampicin | |
rpoC | 764293 | c.924G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764297 | p.Met310Leu | missense_variant | 0.25 | rifampicin | |
rpoC | 764344 | c.975C>T | synonymous_variant | 0.45 | rifampicin | |
rpoC | 764353 | c.984G>T | synonymous_variant | 0.49 | rifampicin | Not assoc w R - Interim |
rpoC | 764365 | c.996C>T | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoC | 764371 | c.1002G>T | synonymous_variant | 0.38 | rifampicin | |
rpoC | 764380 | c.1011G>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 764387 | c.1018T>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 764405 | c.1036_1038delAGGinsCT | frameshift_variant&missense_variant | 0.32 | rifampicin | |
rpoC | 764431 | c.1062G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764434 | c.1065A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764435 | c.1066_1068delAGGinsCA | frameshift_variant&missense_variant | 0.27 | rifampicin | |
rpoC | 764452 | c.1083T>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 764461 | c.1092A>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764485 | c.1116G>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 764491 | c.1122G>T | synonymous_variant | 0.27 | rifampicin | |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764500 | c.1131C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764527 | c.1158C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764530 | c.1161C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764533 | c.1164C>T | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 764605 | c.1236G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 764611 | c.1242G>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764621 | c.1252_1254delCTCinsTG | frameshift_variant&missense_variant | 0.3 | rifampicin | |
rpoC | 764626 | c.1257C>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 764668 | c.1299C>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764713 | c.1344G>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764716 | c.1347G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764746 | c.1377G>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764758 | c.1389C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764803 | c.1434C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R |
rpoC | 764812 | c.1443C>G | synonymous_variant | 0.25 | rifampicin | |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764817 | p.Val483Gly | missense_variant | 0.71 | rifampicin | Uncertain significance |
rpoC | 764824 | c.1455T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764836 | c.1467G>A | synonymous_variant | 0.31 | rifampicin | |
rpoC | 764851 | c.1482C>T | synonymous_variant | 0.3 | rifampicin | |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 764869 | c.1500C>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 764875 | c.1506C>T | synonymous_variant | 0.27 | rifampicin | |
rpoC | 764878 | c.1509C>G | synonymous_variant | 0.27 | rifampicin | |
rpoC | 764887 | c.1518G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 764893 | c.1524T>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.28 | rifampicin | |
rpoC | 764912 | p.Met515Gln | missense_variant | 0.28 | rifampicin | Uncertain significance |
rpoC | 764935 | c.1566T>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765004 | c.1635G>T | synonymous_variant | 0.2 | rifampicin | |
rpoC | 765007 | c.1638T>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765008 | c.1639T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765011 | c.1642_1643delAGinsTC | synonymous_variant | 0.18 | rifampicin | |
rpoC | 765016 | c.1647C>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 765019 | c.1650A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765034 | c.1665T>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 765040 | c.1671T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765041 | c.1672T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765047 | c.1678T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 765055 | c.1686C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 765796 | c.2427C>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 765811 | c.2442T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765814 | c.2445A>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765817 | c.2448G>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 765823 | c.2454C>A | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765826 | c.2457T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765844 | c.2475C>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 765871 | c.2502T>C | synonymous_variant | 0.25 | rifampicin | |
rpoC | 765875 | p.Val836Ile | missense_variant | 0.26 | rifampicin | Uncertain significance |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.28 | rifampicin | |
rpoC | 765904 | c.2535C>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 765908 | c.2539C>T | synonymous_variant | 0.31 | rifampicin | |
rpoC | 765934 | c.2565C>T | synonymous_variant | 0.32 | rifampicin | |
rpoC | 765940 | c.2571A>C | synonymous_variant | 0.31 | rifampicin | |
rpoC | 765946 | c.2577C>T | synonymous_variant | 0.28 | rifampicin | |
rpoC | 765947 | c.2578T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765952 | c.2583G>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 765961 | c.2592G>T | synonymous_variant | 0.28 | rifampicin | |
rpoC | 765962 | c.2593T>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 765967 | c.2598C>T | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 765979 | c.2610C>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765982 | c.2613C>T | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 765994 | c.2625A>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 766714 | c.3345G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766717 | c.3348C>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766720 | c.3351C>T | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766732 | c.3363G>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766738 | c.3369G>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766741 | c.3372G>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766765 | c.3396A>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 766771 | c.3402G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766774 | c.3405T>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766775 | p.Arg1136Lys | missense_variant | 0.21 | rifampicin | |
rpoC | 766798 | c.3429C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 766807 | c.3438T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766837 | c.3468G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766843 | c.3474T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766846 | c.3477C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 766858 | c.3489C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 767002 | c.3633G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 767059 | c.3690T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 767068 | c.3699G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 767104 | c.3735C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 767105 | c.3736_3738delAACinsCG | frameshift_variant&missense_variant | 0.15 | rifampicin | |
rpoC | 767158 | c.3789T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 767162 | p.Asn1265Ala | missense_variant | 0.2 | rifampicin | |
rpoC | 767167 | c.3798C>T | synonymous_variant | 0.21 | rifampicin | |
rpoC | 767174 | p.Asn1269Asp | missense_variant | 0.22 | rifampicin | |
rpoC | 767180 | p.Ala1271Gln | missense_variant | 0.22 | rifampicin | |
rpoC | 767191 | c.3822C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 767197 | c.3828G>A | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 767221 | c.3852C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 767230 | c.3861G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 767233 | c.3864T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781572 | c.13_15delCAGinsAC | frameshift_variant&missense_variant | 0.15 | streptomycin | Uncertain significance |
rpsL | 781595 | c.36T>C | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781598 | c.39G>C | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781605 | p.Ile16Val | missense_variant | 0.19 | streptomycin | Uncertain significance |
rpsL | 781608 | p.Ser17Ala | missense_variant | 0.17 | streptomycin | |
rpsL | 781616 | c.57C>G | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781622 | c.63C>G | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781631 | c.72G>C | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781649 | c.90T>C | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781652 | c.93T>C | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781658 | c.99A>G | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781664 | c.105C>G | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781667 | c.108C>T | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781709 | c.150G>C | synonymous_variant | 0.22 | streptomycin | Not assoc w R - Interim |
rpsL | 781715 | c.156T>C | synonymous_variant | 0.2 | streptomycin | |
rpsL | 781718 | c.159C>G | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781732 | c.174_177delGAGT | frameshift_variant | 0.18 | streptomycin | Uncertain significance |
rpsL | 781739 | c.180_181insCGGC | frameshift_variant | 0.18 | streptomycin | Uncertain significance |
rpsL | 781742 | c.183C>T | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781751 | c.192G>C | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781754 | c.195G>C | synonymous_variant | 0.2 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781814 | c.255C>T | synonymous_variant | 0.28 | streptomycin | |
rpsL | 781817 | c.258G>T | synonymous_variant | 0.28 | streptomycin | |
rpsL | 781829 | c.270G>C | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781835 | c.276T>C | synonymous_variant | 0.22 | streptomycin | Not assoc w R - Interim |
rpsL | 781838 | c.279G>T | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781841 | c.282C>T | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781859 | c.300T>G | synonymous_variant | 0.29 | streptomycin | |
rpsL | 781865 | c.306G>C | synonymous_variant | 0.26 | streptomycin | |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.25 | streptomycin | |
rpsL | 781871 | c.312G>C | synonymous_variant | 0.26 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.26 | streptomycin | |
rpsL | 781898 | c.339A>C | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781901 | c.342C>T | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781907 | c.348T>C | synonymous_variant | 0.23 | streptomycin | |
rpsL | 781916 | c.357T>C | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.24 | streptomycin | Uncertain significance |
rplC | 800204 | c.-605T>C | upstream_gene_variant | 0.97 | linezolid | |
rplC | 800555 | c.-254C>A | upstream_gene_variant | 0.14 | linezolid | |
rplC | 800570 | c.-239C>G | upstream_gene_variant | 0.14 | linezolid | |
rplC | 800574 | c.-235_-234delGTinsAC | upstream_gene_variant | 0.14 | linezolid | |
rplC | 800579 | c.-230C>T | upstream_gene_variant | 0.14 | linezolid | |
rplC | 800591 | c.-218C>T | upstream_gene_variant | 0.14 | linezolid | |
rplC | 800594 | c.-215C>G | upstream_gene_variant | 0.14 | linezolid | |
rplC | 800600 | c.-209G>C | upstream_gene_variant | 0.13 | linezolid | |
rplC | 800612 | c.-197A>G | upstream_gene_variant | 0.13 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 0.14 | linezolid | |
fbiC | 1304526 | c.1596T>G | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304544 | c.1614T>C | synonymous_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304553 | c.1623C>T | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304556 | c.1626C>T | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304559 | p.Glu543Asp | missense_variant | 0.15 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304562 | c.1632G>C | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304568 | c.1638T>C | synonymous_variant | 0.15 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304571 | c.1641G>C | synonymous_variant | 0.15 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304580 | c.1650T>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304613 | c.1683T>C | synonymous_variant | 0.23 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304634 | c.1704C>G | synonymous_variant | 0.2 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304640 | c.1710A>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304646 | c.1716T>C | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304658 | c.1728C>G | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304700 | c.1770G>A | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304709 | c.1779C>G | synonymous_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304715 | c.1785G>T | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
sigE | 1364703 | c.291G>A | synonymous_variant | 0.14 | pyrazinamide | |
sigE | 1364709 | c.297T>C | synonymous_variant | 0.14 | pyrazinamide | |
sigE | 1364712 | c.300T>C | synonymous_variant | 0.15 | pyrazinamide | |
sigE | 1364715 | c.303G>C | synonymous_variant | 0.15 | pyrazinamide | |
sigE | 1364721 | c.309C>G | synonymous_variant | 0.16 | pyrazinamide | |
sigE | 1364736 | c.324T>C | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
sigE | 1364767 | c.355A>C | synonymous_variant | 0.14 | pyrazinamide | |
sigE | 1364790 | c.378T>C | synonymous_variant | 0.15 | pyrazinamide | |
sigE | 1364811 | c.399A>G | synonymous_variant | 0.17 | pyrazinamide | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 0.14 | streptomycin | Uncertain significance |
kanamycin | ||||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471986 | n.141C>T | non_coding_transcript_exon_variant | 0.29 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472019 | n.174G>A | non_coding_transcript_exon_variant | 0.27 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472023 | n.178G>T | non_coding_transcript_exon_variant | 0.26 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472027 | n.184_188delCGGGA | non_coding_transcript_exon_variant | 0.27 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472037 | n.192_193insCTTCC | non_coding_transcript_exon_variant | 0.24 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472040 | n.195T>G | non_coding_transcript_exon_variant | 0.24 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472041 | n.196C>T | non_coding_transcript_exon_variant | 0.23 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472042 | n.197T>G | non_coding_transcript_exon_variant | 0.24 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472053 | n.211_212delGC | non_coding_transcript_exon_variant | 0.24 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472061 | n.216A>T | non_coding_transcript_exon_variant | 0.25 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 0.27 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472106 | n.261G>A | non_coding_transcript_exon_variant | 0.25 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.24 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472150 | n.305T>A | non_coding_transcript_exon_variant | 0.23 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1472251 | n.406G>A | non_coding_transcript_exon_variant | 0.17 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1472380 | n.535G>C | non_coding_transcript_exon_variant | 0.26 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472446 | n.601T>A | non_coding_transcript_exon_variant | 0.33 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472452 | n.607G>A | non_coding_transcript_exon_variant | 0.33 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472464 | n.619A>G | non_coding_transcript_exon_variant | 0.36 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472755 | n.910G>A | non_coding_transcript_exon_variant | 0.36 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472847 | n.1002G>C | non_coding_transcript_exon_variant | 0.31 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472848 | n.1003T>G | non_coding_transcript_exon_variant | 0.3 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472849 | n.1004C>G | non_coding_transcript_exon_variant | 0.3 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472850 | n.1005T>C | non_coding_transcript_exon_variant | 0.3 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472857 | n.1012A>G | non_coding_transcript_exon_variant | 0.32 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472858 | n.1013G>T | non_coding_transcript_exon_variant | 0.32 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472859 | n.1014G>C | non_coding_transcript_exon_variant | 0.32 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472860 | n.1015C>G | non_coding_transcript_exon_variant | 0.32 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.39 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473110 | n.1265T>G | non_coding_transcript_exon_variant | 0.36 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473111 | n.1266A>G | non_coding_transcript_exon_variant | 0.36 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTC | non_coding_transcript_exon_variant | 0.35 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473276 | n.1431A>G | non_coding_transcript_exon_variant | 0.31 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473301 | n.1456T>C | non_coding_transcript_exon_variant | 0.25 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473696 | n.39T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473697 | n.40C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473699 | n.42A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473717 | n.60G>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473746 | n.89T>C | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473770 | n.113T>G | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473811 | n.154C>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1473813 | n.156C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1473823 | n.166T>C | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1473833 | n.176G>A | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1473836 | n.179A>G | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1473876 | n.219G>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473887 | n.230T>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1473888 | n.231T>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473899 | n.242A>G | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474083 | n.426C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474091 | n.434C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474093 | n.436G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474096 | n.439C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474102 | n.445_446insTGAAC | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1474106 | n.449_453delATCAAinsG | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1474135 | n.478G>A | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474174 | n.517A>G | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474181 | n.524C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474183 | n.526T>C | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474185 | n.528G>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474186 | n.529A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474266 | n.609T>C | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474269 | n.612C>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474284 | n.629dupC | non_coding_transcript_exon_variant | 0.22 | capreomycin | |
linezolid | ||||||
rrl | 1474292 | n.635_644delTTCCTCTCCGinsC | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1474303 | n.646A>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474306 | n.649A>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474308 | n.653_654delTG | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474362 | n.705A>G | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474446 | n.789C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474673 | n.1016T>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474676 | n.1019T>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474677 | n.1020A>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474753 | n.1096A>G | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474803 | n.1146G>A | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474830 | n.1173A>G | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475120 | n.1463G>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475429 | n.1772G>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475452 | n.1795C>A | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475479 | n.1822C>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475531 | n.1874C>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475544 | n.1887A>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475545 | n.1888T>G | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475647 | n.1990G>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1475659 | n.2002G>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475762 | n.2105G>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475763 | n.2106C>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475764 | n.2107A>C | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475765 | n.2108A>G | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.35 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1475991 | n.2334T>C | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475995 | n.2338G>A | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476044 | n.2387T>G | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476045 | n.2388G>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476049 | n.2392C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476056 | n.2399G>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476088 | n.2431A>C | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476099 | n.2442A>G | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476103 | n.2446C>G | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476105 | n.2448G>A | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476106 | n.2449A>T | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476110 | n.2453G>C | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476115 | n.2458T>C | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476131 | n.2474C>T | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476160 | n.2503T>C | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476251 | n.2594T>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476256 | n.2599A>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476260 | n.2603A>G | non_coding_transcript_exon_variant | 0.44 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>T | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476299 | n.2642C>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476529 | n.2872A>G | non_coding_transcript_exon_variant | 0.46 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476540 | n.2883C>T | non_coding_transcript_exon_variant | 0.46 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.36 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476594 | n.2937C>T | non_coding_transcript_exon_variant | 0.34 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476603 | n.2946G>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476664 | n.3007T>C | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476665 | n.3008T>C | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476674 | n.3017T>C | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476679 | n.3022T>C | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476689 | n.3032A>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1476690 | n.3033C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476693 | n.3036G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1476695 | n.3038T>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1476716 | n.3059A>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476723 | n.3066T>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1476725 | n.3068C>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476726 | n.3069A>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1476731 | n.3074G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1476732 | n.3075T>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1476746 | n.3089T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1476750 | n.3093T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1476759 | n.3102T>C | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
inhA | 1674534 | c.333G>C | synonymous_variant | 0.14 | ethionamide | |
isoniazid | Not assoc w R - Interim | |||||
inhA | 1674537 | c.336C>G | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
inhA | 1674542 | p.Ala114Glu | missense_variant | 0.16 | ethionamide | |
isoniazid | ||||||
inhA | 1674550 | p.Ser117Ala | missense_variant | 0.14 | ethionamide | |
isoniazid | ||||||
inhA | 1674573 | c.372G>C | synonymous_variant | 0.19 | ethionamide | |
isoniazid | ||||||
inhA | 1674576 | c.375T>C | synonymous_variant | 0.18 | ethionamide | |
isoniazid | ||||||
inhA | 1674582 | c.381T>C | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
inhA | 1674656 | p.Ser152Thr | missense_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1674690 | c.489C>G | synonymous_variant | 0.14 | ethionamide | |
isoniazid | ||||||
inhA | 1674774 | c.573A>C | synonymous_variant | 0.2 | ethionamide | |
isoniazid | ||||||
inhA | 1674789 | c.588G>C | synonymous_variant | 0.23 | ethionamide | |
isoniazid | ||||||
inhA | 1674816 | c.615T>G | synonymous_variant | 0.18 | ethionamide | |
isoniazid | ||||||
inhA | 1674822 | c.621C>G | synonymous_variant | 0.19 | ethionamide | |
isoniazid | ||||||
inhA | 1674825 | c.624C>T | synonymous_variant | 0.19 | ethionamide | |
isoniazid | Not assoc w R - Interim | |||||
inhA | 1674827 | p.Glu209Ala | missense_variant | 0.19 | ethionamide | |
isoniazid | ||||||
inhA | 1674837 | c.636C>G | synonymous_variant | 0.19 | ethionamide | |
isoniazid | ||||||
inhA | 1674839 | p.Ala213Asp | missense_variant | 0.19 | ethionamide | |
isoniazid | ||||||
inhA | 1674846 | p.Ile215Met | missense_variant | 0.21 | ethionamide | |
isoniazid | ||||||
inhA | 1674848 | p.Gln216Arg | missense_variant | 0.21 | ethionamide | |
isoniazid | Uncertain significance | |||||
inhA | 1674858 | c.657G>A | synonymous_variant | 0.2 | ethionamide | |
isoniazid | ||||||
inhA | 1674876 | c.675C>G | synonymous_variant | 0.19 | ethionamide | |
isoniazid | ||||||
inhA | 1674879 | c.678T>G | synonymous_variant | 0.19 | ethionamide | |
isoniazid | ||||||
inhA | 1674882 | c.681G>C | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
inhA | 1674883 | p.Ile228Val | missense_variant | 0.18 | ethionamide | Uncertain significance |
isoniazid | Uncertain significance | |||||
inhA | 1674904 | p.Ala235Pro | missense_variant | 0.16 | ethionamide | |
isoniazid | ||||||
inhA | 1674912 | c.711G>C | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1674924 | c.723G>C | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
rpsA | 1833628 | c.87G>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1833664 | c.123C>G | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1833676 | c.135A>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833685 | c.144G>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833688 | c.147C>T | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833694 | c.153G>T | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833697 | c.156C>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833724 | c.183C>T | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833730 | c.189C>T | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833733 | c.192C>T | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833734 | c.193_195delGCCinsTT | frameshift_variant&missense_variant | 0.18 | pyrazinamide | Uncertain significance |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833894 | p.Ala118Glu | missense_variant | 0.18 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833949 | c.408T>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1833970 | c.429G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833991 | c.450C>A | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833995 | c.454C>T | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834009 | c.468C>T | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834012 | c.471G>T | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834015 | c.474G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834097 | c.556_557delTCinsAG | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834102 | c.561T>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834150 | c.609G>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834153 | c.612T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834154 | c.613_615delAACinsCG | frameshift_variant&missense_variant | 0.16 | pyrazinamide | Uncertain significance |
rpsA | 1834157 | c.616T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834162 | c.621A>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834165 | c.624A>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834169 | p.Thr210Ala | missense_variant | 0.17 | pyrazinamide | Uncertain significance |
rpsA | 1834177 | c.636A>C | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834189 | c.648G>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834213 | c.672G>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834231 | c.690T>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834234 | c.693G>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834240 | c.699T>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834246 | c.705G>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834252 | c.711C>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834261 | c.720A>G | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834264 | c.723G>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834279 | c.738C>T | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834297 | c.756C>T | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834303 | c.762T>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834345 | c.804C>T | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.2 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834361 | c.820T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.2 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834387 | c.846C>T | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834423 | c.882G>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834495 | c.954G>A | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834498 | c.957C>T | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834513 | c.972C>G | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834520 | p.Ala327Ser | missense_variant | 0.23 | pyrazinamide | |
rpsA | 1834528 | c.987T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834531 | c.990C>T | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834540 | c.999G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834543 | c.1002C>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834555 | c.1014T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834556 | p.Ala339Thr | missense_variant | 0.2 | pyrazinamide | Uncertain significance |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 0.98 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
bacA | 2063685 | c.1044G>A | synonymous_variant | 0.98 | streptomycin | Not assoc w R - Interim |
kanamycin | Not assoc w R - Interim | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
bacA | 2063911 | p.Ile273Thr | missense_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
PPE35 | 2169879 | p.Phe245Cys | missense_variant | 0.98 | pyrazinamide | Uncertain significance |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
kasA | 2517941 | c.-174C>G | upstream_gene_variant | 0.16 | isoniazid | |
Rv2477c | 2783586 | p.Ala153Pro | missense_variant | 0.14 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783626 | c.417G>T | synonymous_variant | 0.13 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783665 | c.378A>G | synonymous_variant | 0.14 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
ald | 3086742 | c.-78A>C | upstream_gene_variant | 1.0 | cycloserine | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
lpqB | 3623222 | c.1689A>G | synonymous_variant | 0.95 | bedaquiline | Not assoc w R - Interim |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
lpqB | 3625078 | c.-168G>C | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625090 | c.-180C>A | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625099 | c.-189C>G | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625183 | c.-273G>C | upstream_gene_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625189 | c.1425A>G | synonymous_variant | 0.13 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625240 | c.-330T>C | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625243 | c.-333T>C | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625246 | c.-336G>C | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625252 | c.-342G>T | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625258 | c.-348G>C | upstream_gene_variant | 0.13 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625267 | c.1347T>C | synonymous_variant | 0.14 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625270 | c.-360G>C | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625282 | c.-372C>G | upstream_gene_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625285 | c.-375G>C | upstream_gene_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625312 | c.-402G>C | upstream_gene_variant | 0.13 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626795 | c.-182C>T | upstream_gene_variant | 0.13 | bedaquiline | |
rifampicin | ||||||
rpoA | 3877587 | c.921A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877590 | c.918G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3877593 | c.915C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877638 | c.870T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877647 | c.861C>T | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3877656 | c.852T>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoA | 3877668 | c.840A>G | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3877671 | c.837C>G | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3877677 | c.831G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoA | 3877680 | c.828G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877683 | c.825G>C | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3877686 | c.822A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877695 | c.813C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877704 | c.804G>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3877728 | c.780C>G | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3877731 | c.777G>C | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3877734 | c.774G>C | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3877737 | c.771G>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3877749 | c.759C>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3877758 | c.750G>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3877764 | c.744C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoA | 3877770 | c.738A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877773 | c.735G>C | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3877776 | c.732T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3877785 | c.723C>A | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3877818 | c.690A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3877848 | c.660C>T | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.38 | rifampicin | |
rpoA | 3877866 | c.642G>C | synonymous_variant | 0.39 | rifampicin | |
rpoA | 3877875 | c.633T>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoA | 3877887 | c.621G>C | synonymous_variant | 0.36 | rifampicin | |
rpoA | 3877893 | c.615C>T | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3877905 | c.603A>G | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoA | 3877908 | c.600T>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoA | 3877920 | c.588G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoA | 3877926 | c.582G>C | synonymous_variant | 0.32 | rifampicin | |
rpoA | 3877929 | c.579C>T | synonymous_variant | 0.32 | rifampicin | |
rpoA | 3877962 | c.546G>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoA | 3877965 | c.543C>G | synonymous_variant | 0.32 | rifampicin | |
rpoA | 3877971 | p.Asp179Glu | missense_variant | 0.31 | rifampicin | Uncertain significance |
rpoA | 3877974 | c.534G>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3877989 | c.519A>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3877992 | c.516C>G | synonymous_variant | 0.31 | rifampicin | |
rpoA | 3877998 | c.510G>C | synonymous_variant | 0.3 | rifampicin | |
rpoA | 3878001 | c.507A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3878019 | c.489A>G | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878022 | c.486T>C | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878025 | c.483C>T | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878028 | c.480G>C | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878031 | c.477T>C | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878034 | c.474A>G | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878046 | c.462T>A | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878050 | p.Arg153Lys | missense_variant | 0.23 | rifampicin | |
rpoA | 3878055 | c.453A>G | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878061 | c.447G>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878064 | c.444G>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878070 | c.438T>C | synonymous_variant | 0.29 | rifampicin | |
rpoA | 3878076 | c.432C>T | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878079 | c.429C>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3878082 | c.426T>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878103 | c.405A>G | synonymous_variant | 0.3 | rifampicin | |
rpoA | 3878118 | c.390T>C | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878157 | c.351C>G | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878163 | c.345C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878169 | c.339G>T | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878175 | c.333G>T | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878193 | c.315T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878197 | p.Glu104Ala | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoA | 3878202 | c.306G>C | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
clpC1 | 4038434 | c.2269_2271delGCGinsTC | frameshift_variant&missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4038456 | p.Val750Glu | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4038460 | p.Leu749Met | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4038461 | c.2244G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038486 | p.Gly740Asn | missense_variant | 0.19 | pyrazinamide | |
clpC1 | 4038489 | p.Ala739Gly | missense_variant | 0.18 | pyrazinamide | |
clpC1 | 4038499 | p.Ser736Gly | missense_variant | 0.19 | pyrazinamide | |
clpC1 | 4038509 | p.Asp732Glu | missense_variant | 0.16 | pyrazinamide | |
clpC1 | 4038512 | c.2193C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038519 | p.Arg729Gln | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4038534 | p.Arg724His | missense_variant | 0.14 | pyrazinamide | |
clpC1 | 4038695 | c.2010C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038704 | c.2001T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038707 | c.1998C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038710 | c.1995G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038713 | c.1992T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038721 | c.1984C>T | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038746 | c.1959C>T | synonymous_variant | 0.28 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038755 | c.1950G>T | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4038767 | c.1938G>T | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038770 | c.1935C>T | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038776 | c.1929G>A | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038779 | c.1926C>G | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.27 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>C | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4038842 | c.1863G>C | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4038860 | c.1845G>C | synonymous_variant | 0.26 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.22 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038890 | c.1815G>A | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038911 | c.1794G>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038917 | c.1788C>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038923 | c.1782A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038926 | c.1779G>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038935 | c.1770C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038941 | c.1764G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4038971 | c.1734T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.25 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038980 | c.1725C>T | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.31 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039064 | c.1641C>T | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4039067 | c.1638G>C | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4039073 | c.1632C>T | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4039079 | c.1626C>G | synonymous_variant | 0.34 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039085 | c.1620A>G | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4039091 | c.1614G>C | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4039097 | c.1608G>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4039100 | c.1605C>G | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>G | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039119 | c.1585_1586delTCinsAG | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039121 | c.1584T>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039145 | c.1560G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039169 | c.1536A>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039430 | c.1275T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039442 | c.1263A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039454 | c.1251A>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039463 | c.1242C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039466 | c.1239T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039469 | c.1236T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039472 | c.1233G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039481 | c.1224T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039484 | c.1221T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039487 | c.1218G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039517 | c.1188C>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039556 | c.1149G>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039559 | c.1146C>G | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039570 | c.1135delAinsCTC | frameshift_variant&missense_variant | 0.22 | pyrazinamide | |
clpC1 | 4039575 | c.1128_1129delTG | frameshift_variant | 0.22 | pyrazinamide | |
clpC1 | 4039589 | c.1116G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039592 | c.1113G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039610 | c.1095G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039649 | c.1056G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039682 | c.1023C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039694 | c.1011G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039724 | c.981A>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039733 | c.972G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039739 | c.966C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039742 | c.963C>T | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039748 | c.957G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039751 | c.954A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039757 | c.948A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039766 | c.939T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039769 | c.936C>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039778 | c.927A>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039787 | c.916_918delTCGinsAGC | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039823 | c.882T>A | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039829 | p.Leu292Phe | missense_variant | 0.16 | pyrazinamide | |
clpC1 | 4039850 | c.855T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039865 | c.840T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039991 | c.714G>T | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4040018 | c.687G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040021 | c.684A>C | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040030 | c.675C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4040042 | c.663C>T | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040090 | c.613_615delTCTinsAGC | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4040093 | c.612C>G | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040126 | c.579C>T | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040522 | c.183T>C | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040531 | c.174T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040546 | c.159G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040561 | c.144A>G | synonymous_variant | 0.13 | pyrazinamide | |
glpK | 4138617 | p.Ala380Val | missense_variant | 0.16 | ethambutol | Uncertain significance |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
glpK | 4138622 | c.1134C>G | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138625 | c.1131G>C | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138628 | c.1128T>C | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138634 | c.1122G>T | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138643 | c.1113A>G | synonymous_variant | 0.19 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
glpK | 4138646 | c.1110G>A | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138654 | c.1102C>T | synonymous_variant | 0.19 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
glpK | 4138661 | c.1095T>C | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138664 | c.1092G>A | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138696 | p.Pro354Ala | missense_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138703 | c.1051_1053delCGCinsAA | frameshift_variant&missense_variant | 0.15 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
glpK | 4138718 | c.1038T>C | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138724 | c.1032A>G | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138727 | c.1029C>G | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138730 | c.1026C>G | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138757 | c.999A>G | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138769 | c.987G>C | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138775 | c.981C>G | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4248127 | c.1614G>C | synonymous_variant | 0.14 | ethambutol | |
embB | 4248130 | c.1617G>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248133 | c.1620C>G | synonymous_variant | 0.16 | ethambutol | |
embB | 4248142 | c.1629T>C | synonymous_variant | 0.18 | ethambutol | |
embB | 4248143 | p.Leu544Met | missense_variant | 0.18 | ethambutol | |
embB | 4248157 | c.1644A>G | synonymous_variant | 0.2 | ethambutol | Not assoc w R - Interim |
embB | 4248158 | p.Cys549Ser | missense_variant | 0.2 | ethambutol | |
embB | 4248167 | p.Thr552Ala | missense_variant | 0.22 | ethambutol | |
embB | 4248170 | p.Ala553Ser | missense_variant | 0.23 | ethambutol | |
embB | 4248173 | p.Val554Leu | missense_variant | 0.23 | ethambutol | |
embB | 4248199 | c.1686A>G | synonymous_variant | 0.25 | ethambutol | |
embB | 4248200 | p.Ile563Val | missense_variant | 0.25 | ethambutol | |
embB | 4248206 | c.1693_1695delAGCinsGT | frameshift_variant&missense_variant | 0.25 | ethambutol | |
embB | 4248220 | c.1707A>G | synonymous_variant | 0.25 | ethambutol | Not assoc w R - Interim |
embB | 4248225 | p.Ala571Val | missense_variant | 0.25 | ethambutol | Uncertain significance |
embB | 4248242 | p.Val577Ile | missense_variant | 0.23 | ethambutol | |
embB | 4248252 | p.Gly580Ala | missense_variant | 0.22 | ethambutol | |
embB | 4248264 | p.Phe584Cys | missense_variant | 0.19 | ethambutol | |
embB | 4248277 | c.1764G>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248280 | c.1767C>G | synonymous_variant | 0.15 | ethambutol | |
embB | 4249594 | c.3081G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
ethA | 4326632 | p.His281Pro | missense_variant | 0.98 | ethionamide | Uncertain significance |
ethA | 4328376 | c.-903G>C | upstream_gene_variant | 0.98 | ethionamide | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin |