TB-Profiler result

Run: SRR14802079
Summary

Run ID: SRR14802079

Sample name:

Date: 2024-04-15T03:00:48.836855

Number of reads: 2193723

Percentage reads mapped: 62.68

Median coverage: 66.0

Strain: lineage4.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.2 Euro-American None 0.96
lineage4 Euro-American None 1.0
lineage4.2.1 Euro-American (TUR) None 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Ser297Ala Uncertain significance Mutation from literature
pyrazinamide pncA c.195_*4836del Assoc w R
streptomycin rpsL p.Lys88Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin eis c.-12C>T Assoc w R
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1603_1605delTTGinsCA Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.69 rifampicin Assoc w R
rpsL 781822 p.Lys88Arg missense_variant 0.73 streptomycin Assoc w R
fbiC 1304533 c.1603_1605delTTGinsCA frameshift_variant&missense_variant 0.19 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
inhA 1673425 c.-777C>T upstream_gene_variant 0.97 isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethionamide Assoc w R Alias fabG1_c.-15C>T
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2283844 c.195_*4836del frameshift_variant&stop_lost&splice_region_variant 0.98 pyrazinamide Assoc w R
eis 2715344 c.-12C>T upstream_gene_variant 0.96 kanamycin Assoc w R
embB 4247402 p.Ser297Ala missense_variant 0.95 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 897 c.897A>G synonymous_variant 0.15 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.15 isoniazid
dnaA 915 c.915C>T synonymous_variant 0.15 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.15 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 933 c.933C>G synonymous_variant 0.14 isoniazid
dnaA 993 c.993A>G synonymous_variant 0.13 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.13 isoniazid
gyrA 6676 c.-626T>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7436 c.135C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7442 c.141G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7502 c.201C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7616 c.315G>T synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 7625 c.324G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7706 c.405C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7725 c.424C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7778 c.477G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7847 c.546G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7880 c.579C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7886 c.585T>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8555 c.1254G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8630 c.1329G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8633 c.1332C>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8649 p.Arg450Lys missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8711 c.1410A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8738 c.1437G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8769 p.His490Tyr missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8777 c.1476C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8783 c.1482G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8792 c.1491G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8799 p.Ala500Pro missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8813 c.1512C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8825 c.1524G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8840 c.1539C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8849 c.1548C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8858 c.1557T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8952 p.Gln551Ala missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491247 c.465C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
mshA 575785 c.438T>C synonymous_variant 0.14 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.15 ethionamide
isoniazid
mshA 575800 c.453G>T synonymous_variant 0.15 ethionamide
isoniazid
mshA 575833 c.486C>T synonymous_variant 0.17 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575842 c.495G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.14 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.14 ethionamide
isoniazid
ccsA 619969 p.Val27Ile missense_variant 0.96 capreomycin Not assoc w R - Interim
amikacin Not assoc w R
kanamycin Uncertain significance
nusG 734439 c.186C>G synonymous_variant 0.15 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.2 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.2 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.21 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.22 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.15 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.16 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760139 c.333A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.15 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.21 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.26 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.26 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.28 rifampicin
rpoB 760334 c.528G>A synonymous_variant 0.27 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.22 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.3 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.3 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.22 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760535 c.729C>G synonymous_variant 0.19 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.31 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.31 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.31 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.33 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.37 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.38 rifampicin
rpoB 760778 c.972G>C synonymous_variant 0.38 rifampicin
rpoB 760784 c.978G>C synonymous_variant 0.36 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.36 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.39 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.35 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.34 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760829 c.1023C>T synonymous_variant 0.32 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760848 p.Thr348Ser missense_variant 0.27 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760862 c.1056G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>G synonymous_variant 0.61 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.53 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.53 rifampicin
rpoB 761123 c.1317G>C synonymous_variant 0.4 rifampicin
rpoB 761126 c.1320G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761217 c.1411_1413delCCGinsTC frameshift_variant&missense_variant 0.28 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.28 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>A synonymous_variant 0.17 rifampicin
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761657 c.1851C>A synonymous_variant 0.18 rifampicin
rpoB 761660 c.1854G>A synonymous_variant 0.16 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.17 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.17 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.15 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.17 rifampicin
rpoB 761969 c.2163G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.22 rifampicin
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.22 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.22 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.2 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.2 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.18 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.18 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.26 rifampicin
rpoB 762239 c.2433G>A synonymous_variant 0.26 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.24 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.25 rifampicin
rpoB 762299 c.2493G>A synonymous_variant 0.24 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 0.21 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.23 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762335 c.2529C>T synonymous_variant 0.17 rifampicin
rpoB 762338 c.2532T>C synonymous_variant 0.17 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.19 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.2 rifampicin
rpoB 762353 c.2547C>T synonymous_variant 0.22 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.24 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.23 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.26 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.26 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762410 c.2604T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.22 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.22 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762489 c.2683_2685delGTTinsAC frameshift_variant&missense_variant 0.19 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762878 p.Ile1024Met missense_variant 0.22 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.22 rifampicin Uncertain significance
rpoC 762917 c.-453C>T upstream_gene_variant 0.16 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.15 rifampicin Not assoc w R
rpoC 763049 c.-321G>A upstream_gene_variant 0.17 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763109 c.-261C>G upstream_gene_variant 0.21 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.2 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.21 rifampicin
rpoC 763142 c.-228C>A upstream_gene_variant 0.21 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.24 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.2 rifampicin
rpoC 763193 c.-177C>T upstream_gene_variant 0.15 rifampicin
rpoC 763411 c.42T>C synonymous_variant 0.16 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.24 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.22 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.18 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764153 p.Gln262Lys missense_variant 0.13 rifampicin
rpoC 764227 c.858G>C synonymous_variant 0.16 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.21 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.21 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.18 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.19 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.2 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.25 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.25 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.45 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.38 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCT frameshift_variant&missense_variant 0.32 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.27 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.3 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.29 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.27 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.23 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 0.17 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764621 c.1252_1254delCTCinsTG frameshift_variant&missense_variant 0.3 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.25 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.25 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764817 p.Val483Gly missense_variant 0.71 rifampicin Uncertain significance
rpoC 764824 c.1455T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764836 c.1467G>A synonymous_variant 0.31 rifampicin
rpoC 764851 c.1482C>T synonymous_variant 0.3 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.27 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.27 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.29 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.28 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.28 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.3 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>T synonymous_variant 0.2 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1643delAGinsTC synonymous_variant 0.18 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.18 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.2 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765796 c.2427C>T synonymous_variant 0.14 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.16 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.18 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765844 c.2475C>G synonymous_variant 0.24 rifampicin
rpoC 765871 c.2502T>C synonymous_variant 0.25 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.26 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.28 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.31 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.32 rifampicin
rpoC 765940 c.2571A>C synonymous_variant 0.31 rifampicin
rpoC 765946 c.2577C>T synonymous_variant 0.28 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.28 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.28 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.28 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766714 c.3345G>C synonymous_variant 0.15 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.15 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.15 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.15 rifampicin
rpoC 766732 c.3363G>T synonymous_variant 0.18 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.18 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.18 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.21 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.21 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.21 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767068 c.3699G>C synonymous_variant 0.19 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.15 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.2 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.21 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.22 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.22 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781572 c.13_15delCAGinsAC frameshift_variant&missense_variant 0.15 streptomycin Uncertain significance
rpsL 781595 c.36T>C synonymous_variant 0.19 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.19 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.19 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.17 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.18 streptomycin
rpsL 781622 c.63C>G synonymous_variant 0.19 streptomycin
rpsL 781631 c.72G>C synonymous_variant 0.21 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.22 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.21 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.21 streptomycin
rpsL 781664 c.105C>G synonymous_variant 0.22 streptomycin
rpsL 781667 c.108C>T synonymous_variant 0.24 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.22 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.2 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781732 c.174_177delGAGT frameshift_variant 0.18 streptomycin Uncertain significance
rpsL 781739 c.180_181insCGGC frameshift_variant 0.18 streptomycin Uncertain significance
rpsL 781742 c.183C>T synonymous_variant 0.17 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.18 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.2 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.22 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.28 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.28 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.22 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.22 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>T synonymous_variant 0.22 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.22 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.29 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.26 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.26 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.24 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.24 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.23 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.24 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.24 streptomycin Uncertain significance
rplC 800204 c.-605T>C upstream_gene_variant 0.97 linezolid
rplC 800555 c.-254C>A upstream_gene_variant 0.14 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.14 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.14 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.14 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.14 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.14 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.13 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.13 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.14 linezolid
fbiC 1304526 c.1596T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304556 c.1626C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304700 c.1770G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304709 c.1779C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
sigE 1364703 c.291G>A synonymous_variant 0.14 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.14 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.15 pyrazinamide
sigE 1364715 c.303G>C synonymous_variant 0.15 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.16 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
sigE 1364767 c.355A>C synonymous_variant 0.14 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.15 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.17 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472027 n.184_188delCGGGA non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472037 n.192_193insCTTCC non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473811 n.154C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473833 n.176G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474096 n.439C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474102 n.445_446insTGAAC non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474106 n.449_453delATCAAinsG non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474284 n.629dupC non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474292 n.635_644delTTCCTCTCCGinsC non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474303 n.646A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.36 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.34 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
inhA 1674534 c.333G>C synonymous_variant 0.14 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674537 c.336C>G synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.16 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.14 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.15 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674816 c.615T>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674825 c.624C>T synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674827 p.Glu209Ala missense_variant 0.19 ethionamide
isoniazid
inhA 1674837 c.636C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674839 p.Ala213Asp missense_variant 0.19 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.21 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.21 ethionamide
isoniazid Uncertain significance
inhA 1674858 c.657G>A synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674876 c.675C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674879 c.678T>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674882 c.681G>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674904 p.Ala235Pro missense_variant 0.16 ethionamide
isoniazid
inhA 1674912 c.711G>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.15 ethionamide
isoniazid
rpsA 1833628 c.87G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833688 c.147C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.17 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833734 c.193_195delGCCinsTT frameshift_variant&missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833745 c.204G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.18 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.2 pyrazinamide
rpsA 1833995 c.454C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834000 c.459G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.2 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.19 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.19 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.23 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834531 c.990C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834556 p.Ala339Thr missense_variant 0.2 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 0.98 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063685 c.1044G>A synonymous_variant 0.98 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063911 p.Ile273Thr missense_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
PPE35 2169879 p.Phe245Cys missense_variant 0.98 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.16 isoniazid
Rv2477c 2783586 p.Ala153Pro missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.417G>T synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086742 c.-78A>C upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3623222 c.1689A>G synonymous_variant 0.95 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625078 c.-168G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625090 c.-180C>A upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625099 c.-189C>G upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625183 c.-273G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625240 c.-330T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625243 c.-333T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625246 c.-336G>C upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625252 c.-342G>T upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.13 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625282 c.-372C>G upstream_gene_variant 0.15 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
lpqB 3625312 c.-402G>C upstream_gene_variant 0.13 bedaquiline
rifampicin
mtrB 3626795 c.-182C>T upstream_gene_variant 0.13 bedaquiline
rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877590 c.918G>C synonymous_variant 0.15 rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.27 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.26 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.26 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.25 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.27 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.27 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.27 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.28 rifampicin
rpoA 3877749 c.759C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877758 c.750G>C synonymous_variant 0.28 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.26 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.28 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.38 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.39 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>C synonymous_variant 0.36 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.32 rifampicin
rpoA 3877929 c.579C>T synonymous_variant 0.32 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877965 c.543C>G synonymous_variant 0.32 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.31 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877989 c.519A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>G synonymous_variant 0.31 rifampicin
rpoA 3877998 c.510G>C synonymous_variant 0.3 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.25 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.25 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.26 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.25 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.25 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.25 rifampicin
rpoA 3878046 c.462T>A synonymous_variant 0.25 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.23 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.24 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.28 rifampicin
rpoA 3878064 c.444G>C synonymous_variant 0.28 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.29 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.28 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.28 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.3 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.26 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.22 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>T synonymous_variant 0.24 rifampicin
rpoA 3878175 c.333G>T synonymous_variant 0.23 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878202 c.306G>C synonymous_variant 0.2 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
clpC1 4038434 c.2269_2271delGCGinsTC frameshift_variant&missense_variant 0.15 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.15 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.15 pyrazinamide
clpC1 4038461 c.2244G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.19 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.18 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.19 pyrazinamide
clpC1 4038509 p.Asp732Glu missense_variant 0.16 pyrazinamide
clpC1 4038512 c.2193C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.15 pyrazinamide
clpC1 4038534 p.Arg724His missense_variant 0.14 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038746 c.1959C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>T synonymous_variant 0.29 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.28 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.28 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.17 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.14 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038926 c.1779G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038935 c.1770C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039119 c.1585_1586delTCinsAG synonymous_variant 0.23 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039178 c.1527G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039570 c.1135delAinsCTC frameshift_variant&missense_variant 0.22 pyrazinamide
clpC1 4039575 c.1128_1129delTG frameshift_variant 0.22 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.22 pyrazinamide
clpC1 4039823 c.882T>A synonymous_variant 0.2 pyrazinamide
clpC1 4039829 p.Leu292Phe missense_variant 0.16 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.22 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.13 pyrazinamide
glpK 4138617 p.Ala380Val missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138622 c.1134C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138628 c.1128T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138646 c.1110G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138661 c.1095T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138664 c.1092G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138696 p.Pro354Ala missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1051_1053delCGCinsAA frameshift_variant&missense_variant 0.15 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138718 c.1038T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138727 c.1029C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138775 c.981C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248127 c.1614G>C synonymous_variant 0.14 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.16 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.16 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.18 ethambutol
embB 4248143 p.Leu544Met missense_variant 0.18 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248158 p.Cys549Ser missense_variant 0.2 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.22 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.23 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.23 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.25 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.25 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.25 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4248225 p.Ala571Val missense_variant 0.25 ethambutol Uncertain significance
embB 4248242 p.Val577Ile missense_variant 0.23 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.22 ethambutol
embB 4248264 p.Phe584Cys missense_variant 0.19 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.16 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.15 ethambutol
embB 4249594 c.3081G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
ethA 4326632 p.His281Pro missense_variant 0.98 ethionamide Uncertain significance
ethA 4328376 c.-903G>C upstream_gene_variant 0.98 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin