TB-Profiler result

Run: ERR4819051
Summary

Run ID: ERR4819051

Sample name:

Date: 2024-03-26T20:44:58.728344

Number of reads: 156959

Percentage reads mapped: 7.61

Median coverage: 1.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.98
lineage4.9 Euro-American (H37Rv-like) None 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 822 c.822A>G synonymous_variant 0.91 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.91 isoniazid Not assoc w R - Interim
dnaA 840 p.Glu280Asp missense_variant 0.91 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.91 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.91 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.91 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.91 isoniazid Not assoc w R - Interim
gyrB 5326 c.87T>G synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrB 5329 c.90C>A synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrB 5368 c.129C>T synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrB 5371 c.132T>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrB 5374 c.135C>G synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrB 5377 c.138T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5383 c.144G>A synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6148 c.909C>G synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrB 6160 c.921C>G synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6178 c.939C>T synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6184 c.945C>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6187 c.948C>T synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6193 c.954G>A synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6532 c.-770C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6535 c.-767C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6538 c.-764C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6550 c.-752A>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6556 c.-746C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6565 c.-737G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6568 c.-734C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6580 c.-722C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6586 c.-716T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6590 p.Arg451Ser missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6631 c.-671C>T upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>G upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrB 6724 c.1485G>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6730 c.-572A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6745 c.-557T>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6775 c.-527G>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 6803 c.-499C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6808 c.1569C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 1.0 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7592 c.291G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 7691 c.390C>A synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 7715 c.414G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8111 c.810G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8156 c.855T>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8190 p.Ala297Thr missense_variant 0.95 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8201 c.900C>G synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8630 c.1329G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8912 c.1611G>A synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>G synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>T synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 9329 c.2028C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCC frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0565c 657636 c.-167_-166delAGinsTC upstream_gene_variant 1.0 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 1.0 ethionamide
Rv0565c 657644 c.-174G>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 1.0 ethionamide
Rv0565c 657670 c.-200A>G upstream_gene_variant 1.0 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.94 ethionamide
Rv0565c 657686 c.-216C>T upstream_gene_variant 1.0 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 1.0 ethionamide
Rv0565c 657703 c.-233C>A upstream_gene_variant 1.0 ethionamide
hadA 731774 c.-156T>C upstream_gene_variant 1.0 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 1.0 isoniazid
hadA 731807 c.-123C>T upstream_gene_variant 1.0 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 1.0 isoniazid
nusG 734439 c.186C>G synonymous_variant 1.0 rifampicin
nusG 734451 c.198G>C synonymous_variant 1.0 rifampicin
nusG 734454 c.201A>G synonymous_variant 1.0 rifampicin
nusG 734460 c.207G>C synonymous_variant 1.0 rifampicin
nusG 734463 c.210G>C synonymous_variant 1.0 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.96 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.93 rifampicin
rpoB 760121 c.315T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 1.0 rifampicin
rpoB 760178 c.372G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.92 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 1.0 rifampicin
rpoB 760310 c.504G>C synonymous_variant 1.0 rifampicin
rpoB 760313 c.507G>C synonymous_variant 1.0 rifampicin
rpoB 760316 c.510C>G synonymous_variant 1.0 rifampicin
rpoB 760325 c.519G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 1.0 rifampicin
rpoB 760331 c.525G>T synonymous_variant 1.0 rifampicin
rpoB 760337 c.531C>G synonymous_variant 1.0 rifampicin
rpoB 760340 c.534G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 1.0 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.95 rifampicin
rpoB 760407 c.601_603delAGCinsGT frameshift_variant&missense_variant 0.95 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 1.0 rifampicin
rpoB 760514 c.708C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 1.0 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 1.0 rifampicin
rpoB 760541 c.735G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 1.0 rifampicin
rpoB 760611 c.805T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760625 c.819C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 1.0 rifampicin
rpoB 760655 c.849A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 1.0 rifampicin
rpoB 760674 c.868T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760754 c.948G>C synonymous_variant 0.92 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.92 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.92 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.92 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.92 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.92 rifampicin
rpoB 760796 c.990A>G synonymous_variant 0.92 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761217 p.Pro471Ser missense_variant 1.0 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.87 rifampicin
rpoB 761301 c.1495C>A synonymous_variant 0.67 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.88 rifampicin
rpoB 761346 p.Val514Ile missense_variant 0.88 rifampicin
rpoB 761355 p.Val517Lys missense_variant 0.88 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.88 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.88 rifampicin
rpoB 761555 c.1749G>A synonymous_variant 0.92 rifampicin
rpoB 761558 c.1752C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 1.0 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.96 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.96 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.94 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.94 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.88 rifampicin
rpoB 761819 c.2013G>A synonymous_variant 0.8 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.8 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.92 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.95 rifampicin
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.95 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 1.0 rifampicin Uncertain significance
rpoB 762131 c.2325C>T synonymous_variant 1.0 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 1.0 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 1.0 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.94 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.88 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.86 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 0.93 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 0.88 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.86 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 1.0 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 1.0 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 1.0 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 1.0 rifampicin
rpoC 762560 c.-810A>T upstream_gene_variant 0.92 rifampicin
rpoC 762563 c.-807G>T upstream_gene_variant 0.92 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.92 rifampicin Uncertain significance
rpoC 762896 c.-474G>C upstream_gene_variant 0.94 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 762926 c.-444C>G upstream_gene_variant 0.94 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 1.0 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 1.0 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 1.0 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 1.0 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 1.0 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 1.0 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763423 p.Glu18Asp missense_variant 0.9 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCC frameshift_variant&missense_variant 0.9 rifampicin
rpoC 763433 c.64_66delCAAinsAT frameshift_variant&missense_variant 0.9 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.83 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763495 c.126G>A synonymous_variant 0.94 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 1.0 rifampicin
rpoC 763582 c.213G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.96 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 1.0 rifampicin
rpoC 763702 c.333C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 1.0 rifampicin
rpoC 763732 c.363C>T synonymous_variant 1.0 rifampicin
rpoC 763738 c.369G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 1.0 rifampicin
rpoC 763744 c.375G>C synonymous_variant 1.0 rifampicin
rpoC 763765 c.396T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763781 c.412_414delTCGinsGC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 763789 c.420C>T synonymous_variant 1.0 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 1.0 rifampicin
rpoC 763801 c.432C>T synonymous_variant 1.0 rifampicin
rpoC 763807 c.438T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 1.0 rifampicin
rpoC 763819 c.450G>C synonymous_variant 1.0 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 763996 c.627T>C synonymous_variant 1.0 rifampicin
rpoC 764002 c.633C>G synonymous_variant 1.0 rifampicin
rpoC 764005 c.636G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764227 c.858G>C synonymous_variant 0.82 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.85 rifampicin
rpoC 764254 c.885G>A synonymous_variant 0.87 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.92 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.86 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764285 p.Gly306Ser missense_variant 0.93 rifampicin
rpoC 764308 c.939G>C synonymous_variant 0.94 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.89 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.91 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.95 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.97 rifampicin
rpoC 764491 c.1122G>C synonymous_variant 0.97 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 1.0 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.93 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.9 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.92 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764843 p.Ala492Ser missense_variant 0.92 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>G synonymous_variant 0.89 rifampicin
rpoC 764875 c.1506C>G synonymous_variant 0.87 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.86 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.86 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.91 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.91 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.92 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 1.0 rifampicin
rpoC 765047 c.1678T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 1.0 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 1.0 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765100 c.1731G>C synonymous_variant 1.0 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 1.0 rifampicin
rpoC 765370 c.2001G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765379 c.2010G>T synonymous_variant 1.0 rifampicin
rpoC 765383 c.2014_2016delATGinsCC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 765405 p.Leu679Arg missense_variant 1.0 rifampicin Uncertain significance
rpoC 765409 c.2040T>C synonymous_variant 1.0 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 1.0 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 1.0 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765533 p.Tyr722His missense_variant 1.0 rifampicin Uncertain significance
rpoC 765814 c.2445A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765838 c.2469G>T synonymous_variant 1.0 rifampicin
rpoC 765875 p.Val836Ile missense_variant 1.0 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 1.0 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766294 c.2925C>T synonymous_variant 0.95 rifampicin
rpoC 766299 p.Thr977Met missense_variant 0.95 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 766315 c.2946C>G synonymous_variant 0.96 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.97 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.97 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 766369 c.3000C>G synonymous_variant 0.96 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.94 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.94 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.94 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.8 rifampicin
rpoC 766693 c.3324C>G synonymous_variant 0.73 rifampicin
rpoC 766703 p.Met1112Leu missense_variant 0.73 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.82 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.85 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.85 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.89 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.89 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.89 rifampicin
rpoC 766783 c.3414C>T synonymous_variant 0.9 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>A synonymous_variant 1.0 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 1.0 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 1.0 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 1.0 rifampicin
rpoC 767206 c.3837C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 1.0 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 1.0 rifampicin
mmpL5 775937 c.2544G>C synonymous_variant 0.64 clofazimine
bedaquiline
mmpL5 775961 c.2520C>G synonymous_variant 0.9 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.92 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.89 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.54 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776009 c.2472A>G synonymous_variant 0.96 clofazimine
bedaquiline
mmpL5 776015 c.2464_2466delATCinsGG frameshift_variant&missense_variant 0.72 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776020 c.2461C>T synonymous_variant 0.5 clofazimine
bedaquiline
mmpL5 776024 c.2457G>A synonymous_variant 0.65 clofazimine
bedaquiline
mmpL5 776039 c.2442C>A synonymous_variant 0.61 clofazimine
bedaquiline
mmpL5 776051 c.2428_2430delTTGinsCC frameshift_variant&missense_variant 0.33 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776056 p.Val809Leu missense_variant 0.35 clofazimine
bedaquiline
mmpL5 776072 c.2409C>G synonymous_variant 0.9 clofazimine
bedaquiline
mmpL5 776075 c.2406C>G synonymous_variant 0.92 clofazimine
bedaquiline
rpsL 781586 c.27C>T synonymous_variant 0.85 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.85 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.85 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.85 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.85 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.92 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.96 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.96 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.95 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.95 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.91 streptomycin
rpsL 781676 c.117C>G synonymous_variant 0.94 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.93 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.92 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.92 streptomycin Not assoc w R - Interim
rpsL 781793 c.234G>A synonymous_variant 0.94 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.95 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.95 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.95 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.95 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.95 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.94 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>C synonymous_variant 1.0 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 1.0 streptomycin
rpsL 781871 c.312G>C synonymous_variant 1.0 streptomycin
rpsL 781877 c.318T>C synonymous_variant 1.0 streptomycin
rpsL 781892 c.333A>G synonymous_variant 1.0 streptomycin
rpsL 781895 c.336G>A synonymous_variant 1.0 streptomycin
rpsL 781907 c.348T>C synonymous_variant 1.0 streptomycin
rpsL 781916 c.357T>C synonymous_variant 1.0 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 1.0 streptomycin Uncertain significance
rplC 800633 c.-176T>C upstream_gene_variant 0.91 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.94 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.94 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.95 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.95 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.95 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 1.0 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 1.0 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 1.0 linezolid
rplC 800738 c.-71T>G upstream_gene_variant 1.0 linezolid
rplC 800744 c.-65G>A upstream_gene_variant 1.0 linezolid
rplC 800880 c.72A>G synonymous_variant 0.8 linezolid
rplC 800889 c.81C>G synonymous_variant 0.8 linezolid
rplC 800892 c.84G>C synonymous_variant 0.87 linezolid
rplC 800913 c.105G>C synonymous_variant 1.0 linezolid
rplC 800916 c.108A>G synonymous_variant 1.0 linezolid
rplC 800919 c.111C>G synonymous_variant 1.0 linezolid
rplC 800931 c.123G>C synonymous_variant 1.0 linezolid
fbiC 1304574 c.1644C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
atpE 1461050 c.6C>T synonymous_variant 1.0 bedaquiline
atpE 1461056 c.12T>A synonymous_variant 1.0 bedaquiline
atpE 1461071 c.27C>A synonymous_variant 1.0 bedaquiline
atpE 1461086 c.42A>T synonymous_variant 1.0 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 1.0 bedaquiline
atpE 1461104 c.60C>T synonymous_variant 1.0 bedaquiline
atpE 1461107 c.63C>T synonymous_variant 1.0 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 1.0 bedaquiline
rrs 1471918 n.74_78delAAGGT non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471929 n.84C>T non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>T non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471935 n.92_96delCTCGA non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472027 n.182C>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473813 n.156C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631delCinsTCT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053delTinsACAC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474718 n.1061A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474720 n.1065_1066delTG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475297 n.1640C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475343 n.1686A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475358 n.1701T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475366 n.1709G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475403 n.1746T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>C non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476692 n.3035T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
inhA 1674489 c.288G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674513 c.312C>G synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674534 c.333G>A synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 1.0 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 1.0 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674567 c.366C>T synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674570 c.369G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674585 c.384T>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674589 p.Met130Leu missense_variant 1.0 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 1.0 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.95 ethionamide
isoniazid
inhA 1674639 c.438C>G synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674651 c.450C>T synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.95 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674663 c.462G>C synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674669 c.468G>T synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCC frameshift_variant&missense_variant 1.0 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674745 p.Tyr182Val missense_variant 1.0 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674759 c.558G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674813 c.612C>T synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674816 c.615T>G synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674828 p.Glu209Asp missense_variant 0.97 ethionamide
isoniazid
inhA 1674834 c.633C>G synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.97 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674883 c.682_684delATCinsCG frameshift_variant&missense_variant 0.96 ethionamide
isoniazid
inhA 1674904 c.703_705delGCGinsCC frameshift_variant&missense_variant 0.94 ethionamide
isoniazid
rpsA 1833772 c.231C>T synonymous_variant 0.94 pyrazinamide
rpsA 1833778 c.237C>T synonymous_variant 0.94 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.94 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.94 pyrazinamide
rpsA 1833796 c.255G>A synonymous_variant 0.95 pyrazinamide
rpsA 1833805 c.264C>G synonymous_variant 0.95 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.95 pyrazinamide
rpsA 1833817 c.276C>G synonymous_variant 0.95 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.95 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.96 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.96 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.95 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.95 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 1.0 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 1.0 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 1.0 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 1.0 pyrazinamide
rpsA 1833994 c.453G>A synonymous_variant 1.0 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 1.0 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834093 c.552G>T synonymous_variant 1.0 pyrazinamide
rpsA 1834096 c.555G>T synonymous_variant 1.0 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.97 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.96 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.91 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.95 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.96 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.96 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.97 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.96 pyrazinamide Uncertain significance
rpsA 1834465 c.924T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.96 pyrazinamide
rpsA 1834474 c.933C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.95 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.95 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.93 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.91 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834738 p.Glu399Asp missense_variant 1.0 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 1.0 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 1.0 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834776 p.Ala412Asp missense_variant 1.0 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834789 c.1248T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 1.0 pyrazinamide
kasA 2517917 c.-198G>T upstream_gene_variant 1.0 isoniazid
kasA 2518738 c.624G>C synonymous_variant 0.8 isoniazid
kasA 2518741 c.627G>T synonymous_variant 0.82 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.92 isoniazid
kasA 2518774 c.660C>T synonymous_variant 0.92 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.92 isoniazid
kasA 2518785 p.Glu224Ala missense_variant 0.92 isoniazid
kasA 2518787 p.Arg225Gly missense_variant 0.92 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.92 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.92 isoniazid
kasA 2518796 c.682C>A synonymous_variant 0.92 isoniazid
kasA 2519146 c.1032C>T synonymous_variant 0.91 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.93 isoniazid
kasA 2519161 c.1047G>C synonymous_variant 0.93 isoniazid
kasA 2519170 c.1056G>C synonymous_variant 0.94 isoniazid
kasA 2519181 p.Val356Ala missense_variant 0.94 isoniazid
kasA 2519194 c.1080G>C synonymous_variant 0.94 isoniazid
kasA 2519195 c.1081_1083delACGinsGC frameshift_variant&missense_variant 0.94 isoniazid
kasA 2519203 c.1089C>T synonymous_variant 0.94 isoniazid
kasA 2519224 c.1110C>A synonymous_variant 0.93 isoniazid
Rv2477c 2782945 c.1098C>G synonymous_variant 0.9 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.9 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783140 c.903C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783152 c.891G>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783947 c.96C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783957 p.Tyr29Leu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 p.Ser27Asn missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783986 c.57G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
thyX 3067328 c.618G>C synonymous_variant 0.85 para-aminosalicylic_acid
thyX 3067340 c.606G>A synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.92 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.92 para-aminosalicylic_acid
thyX 3067400 c.546C>G synonymous_variant 0.91 para-aminosalicylic_acid
thyX 3067403 c.543C>G synonymous_variant 0.91 para-aminosalicylic_acid
mtrA 3626711 p.Thr213Gln missense_variant 1.0 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626773 c.-160C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 1.0 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626792 c.-179G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626795 c.-182C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626846 c.504G>A synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626996 c.-383G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626999 c.-386G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627005 c.-392G>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627011 c.-398T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627014 c.-401G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627017 c.-404G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627043 p.Ile103Val missense_variant 1.0 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627073 c.277C>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627080 c.270T>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627125 c.-512C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627143 c.-530G>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.88 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.88 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCC frameshift_variant&missense_variant 1.0 bedaquiline
rifampicin
mtrA 3627307 p.Ala15Pro missense_variant 1.0 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627320 c.-707C>A upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627325 c.-712T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627326 c.-713T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
rpoA 3877560 c.948C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 1.0 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 1.0 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 1.0 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 1.0 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 1.0 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>A synonymous_variant 1.0 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 1.0 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 1.0 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 1.0 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 1.0 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 1.0 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 1.0 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.95 rifampicin Uncertain significance
rpoA 3878164 p.Gly115Asn missense_variant 0.95 rifampicin
rpoA 3878175 c.333G>T synonymous_variant 0.95 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.95 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878232 c.276G>C synonymous_variant 0.9 rifampicin
clpC1 4038269 p.Pro812Gln missense_variant 0.89 pyrazinamide
clpC1 4038272 c.2433T>C synonymous_variant 0.9 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.9 pyrazinamide
clpC1 4038290 p.Asp805Glu missense_variant 0.92 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.92 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsCC frameshift_variant&missense_variant 1.0 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038320 c.2385G>A synonymous_variant 1.0 pyrazinamide
clpC1 4038329 p.Glu792Asp missense_variant 1.0 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.94 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.91 pyrazinamide
clpC1 4038551 c.2154C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038578 c.2127C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038587 c.2118C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038605 c.2100G>A synonymous_variant 1.0 pyrazinamide
clpC1 4038613 p.Asn698His missense_variant 1.0 pyrazinamide
clpC1 4038614 c.2091C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038746 c.1959C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.94 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.94 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.94 pyrazinamide
clpC1 4038770 c.1935C>G synonymous_variant 0.94 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.94 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.95 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.96 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.96 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.97 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.97 pyrazinamide
clpC1 4038839 c.1866G>T synonymous_variant 0.96 pyrazinamide
clpC1 4038860 c.1845G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.95 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.92 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.92 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.92 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.92 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038932 c.1773G>A synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4038953 c.1752A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.91 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.91 pyrazinamide
clpC1 4039082 c.1623C>T synonymous_variant 0.86 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.85 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.92 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.88 pyrazinamide
clpC1 4039124 c.1581C>A synonymous_variant 0.88 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.88 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.86 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.91 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.91 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.91 pyrazinamide
clpC1 4039238 c.1467C>G synonymous_variant 0.95 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039250 c.1455C>G synonymous_variant 0.95 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.93 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.93 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.92 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.85 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039766 c.939T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 1.0 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039814 c.891C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039942 c.763C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 1.0 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 1.0 pyrazinamide
clpC1 4040003 c.702G>T synonymous_variant 1.0 pyrazinamide
clpC1 4040009 c.696C>A synonymous_variant 1.0 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 1.0 pyrazinamide
clpC1 4040501 c.204C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4040644 c.61A>C synonymous_variant 0.8 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.8 pyrazinamide
clpC1 4040669 c.36C>T synonymous_variant 0.8 pyrazinamide
embC 4240756 c.894G>C synonymous_variant 0.9 ethambutol
embC 4240759 c.897C>G synonymous_variant 0.9 ethambutol
embC 4240765 c.903C>G synonymous_variant 0.9 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.92 ethambutol
embC 4240778 c.916_918delCATinsAC frameshift_variant&missense_variant 0.92 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.92 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.92 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.9 ethambutol
embB 4247449 c.936C>T synonymous_variant 1.0 ethambutol
embB 4247452 c.939C>G synonymous_variant 1.0 ethambutol
embB 4247464 c.951C>G synonymous_variant 1.0 ethambutol
embB 4247470 c.957T>C synonymous_variant 1.0 ethambutol
embB 4247491 c.978G>C synonymous_variant 1.0 ethambutol
embB 4247497 c.984T>C synonymous_variant 1.0 ethambutol
embB 4247500 c.987C>G synonymous_variant 1.0 ethambutol
embB 4248199 c.1686A>C synonymous_variant 0.9 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.9 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.9 ethambutol
embB 4248211 c.1698G>C synonymous_variant 0.9 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.91 ethambutol Not assoc w R - Interim
embB 4248223 c.1710G>C synonymous_variant 0.91 ethambutol
embB 4248233 c.1720C>T synonymous_variant 0.91 ethambutol