TB-Profiler result

Run: ERR4797201
Summary

Run ID: ERR4797201

Sample name:

Date: 2024-10-04T03:37:35.459845

Number of reads: 5425275

Percentage reads mapped: 70.63

Median coverage: 153.0

Strain: lineage1.2.2.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.2 Indo-Oceanic RD239 0.95
lineage1.2.2.2 Indo-Oceanic RD239 0.97
La1.2.BCG M.bovis None 0.1
lineage1 Indo-Oceanic RD239 0.9
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.2 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1092 c.1092T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.19 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.19 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.19 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.19 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.17 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.19 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.19 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.19 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.19 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.17 isoniazid
dnaA 1176 c.1176A>G synonymous_variant 0.2 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.17 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.18 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.19 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.16 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.21 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.19 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.18 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.16 isoniazid
dnaA 1294 p.Arg432Cys missense_variant 0.84 isoniazid Uncertain significance
gyrB 5075 c.-165C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6112 p.Met291Ile missense_variant 0.91 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6238 c.999G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.2 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6703 c.-599G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6798 p.Gly520Ala missense_variant 0.16 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6811 c.1572C>T synonymous_variant 0.19 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6866 c.-436C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6889 c.-413G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6931 c.1692A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7007 c.-295C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7268 c.-34C>T upstream_gene_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7436 c.135C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7442 c.141G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7523 c.222C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCTG synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTTG synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 p.Asp367Asn missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8452 p.Ala384Val missense_variant 0.85 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8543 c.1242C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8558 c.1257C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCTC synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8882 c.1581G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8912 c.1611G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9200 c.1899A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 p.Asp669Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
Rv0010c 13298 p.Ile87Met missense_variant 0.99 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13699 c.-141A>G upstream_gene_variant 0.98 isoniazid Not assoc w R
fgd1 490827 c.45C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490851 c.69A>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490857 c.75C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490869 c.87C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 490887 c.105G>A synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490890 c.108C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490902 c.120T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491094 c.312C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491106 c.324T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Asp missense_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491151 c.369G>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491184 c.402A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491196 c.414A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.39 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491283 p.Asp167Glu missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.25 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491295 c.513C>G synonymous_variant 0.22 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491302 p.Ile174Val missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491313 c.531C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491319 c.537G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491355 c.573C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575659 c.312A>G synonymous_variant 0.18 isoniazid
ethionamide
mshA 575662 c.315C>G synonymous_variant 0.18 isoniazid
ethionamide
mshA 575674 c.327G>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575695 c.348C>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ethionamide
mshA 575701 c.354G>A synonymous_variant 0.16 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.19 isoniazid
ethionamide
mshA 575719 c.372C>T synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575737 c.390T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575755 c.408G>A synonymous_variant 0.16 isoniazid
ethionamide
mshA 575770 c.423G>A synonymous_variant 0.17 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.17 isoniazid
ethionamide
mshA 575812 c.465C>T synonymous_variant 0.17 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.18 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.18 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.18 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 576108 p.Ala254Gly missense_variant 0.31 isoniazid
ethionamide
ccsA 619570 c.-321G>C upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619574 c.-317G>A upstream_gene_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 619579 c.-312G>C upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619584 c.-307A>T upstream_gene_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 619591 c.-300G>C upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619609 c.-282G>C upstream_gene_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620249 p.Ser120Cys missense_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620268 c.378G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>T synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620298 c.408G>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620310 c.420C>T synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620376 c.486G>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.17 kanamycin
capreomycin
amikacin
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.17 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.21 ethionamide
hadA 731732 c.-198G>A upstream_gene_variant 0.16 isoniazid
hadA 731741 c.-189G>A upstream_gene_variant 0.17 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.17 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.22 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.22 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.25 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.25 isoniazid
nusG 734116 c.-138T>C upstream_gene_variant 0.96 rifampicin Not assoc w R
nusG 734424 c.171G>A synonymous_variant 0.16 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.18 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.2 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.2 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.17 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.21 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.3 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.32 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.32 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.32 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.32 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.34 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.31 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.31 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.3 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.31 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.32 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.29 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.26 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.26 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.27 rifampicin
rpoB 760598 c.792C>G synonymous_variant 0.26 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.27 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.21 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.21 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.2 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.2 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.2 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.24 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.25 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.23 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.24 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.23 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>G synonymous_variant 0.23 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.25 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.26 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.27 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.26 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.28 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.31 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.39 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.38 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.37 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.33 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.31 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.24 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.21 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.25 rifampicin
rpoB 761360 c.1554T>G synonymous_variant 0.21 rifampicin
rpoB 761362 p.Ser519Thr missense_variant 0.22 rifampicin
rpoB 761373 p.Val523His missense_variant 0.21 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.26 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.24 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.2 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.18 rifampicin
rpoB 761439 p.Asp545Lys missense_variant 0.18 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.19 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.18 rifampicin
rpoB 761452 p.Val549Asp missense_variant 0.17 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.18 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.2 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.21 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.2 rifampicin
rpoB 761501 c.1695G>C synonymous_variant 0.18 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.18 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.25 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.27 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.23 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.2 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.18 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.18 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.2 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.21 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.21 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.19 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.19 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.18 rifampicin
rpoB 761815 p.Ala670Asp missense_variant 0.15 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.17 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.2 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.21 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.2 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.19 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.19 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.19 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.19 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.19 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.2 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.29 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.29 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.21 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.2 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.2 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.25 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.26 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.25 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762299 c.2493G>C synonymous_variant 0.23 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.24 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.24 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.27 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.22 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.21 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.17 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.2 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.21 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.19 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.22 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.2 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.2 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.2 rifampicin Uncertain significance
rpoC 762521 c.-849C>G upstream_gene_variant 0.2 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.16 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.19 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.39 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.42 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.62 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.37 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.37 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>G upstream_gene_variant 0.27 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.26 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.23 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.21 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.22 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.27 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.38 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.32 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.36 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.35 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.34 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.38 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.36 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.33 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.3 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.29 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.27 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.27 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.27 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.27 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.26 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.69 rifampicin Not assoc w R
rpoC 763886 p.Arg173Ser missense_variant 0.7 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.24 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.24 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.18 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.23 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.22 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.23 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.26 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.24 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.24 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.23 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.24 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.23 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.22 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.21 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.23 rifampicin
rpoC 764128 c.759C>G synonymous_variant 0.25 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.26 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.28 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.28 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.31 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.38 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.37 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.37 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.35 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.48 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764374 c.1005C>T synonymous_variant 0.33 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.27 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.25 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.24 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.25 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.29 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.24 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.28 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.28 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.29 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.26 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.22 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.27 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.34 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.25 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764923 c.1554A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.21 rifampicin
rpoC 764941 c.1572G>A synonymous_variant 0.21 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764980 c.1611C>T synonymous_variant 0.24 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.24 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.24 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.19 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>G synonymous_variant 0.18 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765349 c.1980T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765370 c.2001G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.2 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.23 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.21 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.21 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.32 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.31 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.31 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.31 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.26 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.26 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.25 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.25 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.29 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.28 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.28 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.28 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.27 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.29 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.29 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.3 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.35 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765997 c.2628T>C synonymous_variant 0.33 rifampicin
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.36 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.39 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.4 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.4 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.4 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.37 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.33 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.26 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.22 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766178 p.Ile937Val missense_variant 0.16 rifampicin
rpoC 766258 c.2889T>C synonymous_variant 0.19 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.15 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.18 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.2 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.23 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.23 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.23 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.26 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.27 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.26 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.24 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.29 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.28 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.25 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.22 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.22 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.23 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.24 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.23 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.23 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.24 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.22 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.2 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.17 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.17 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.18 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.18 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.21 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.23 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.22 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.19 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.22 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.19 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.19 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.31 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.3 rifampicin
rpoC 766777 c.3408C>T synonymous_variant 0.3 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.33 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.34 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.28 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.28 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.28 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.29 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.34 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.32 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.29 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.29 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.29 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.28 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.27 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.32 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.31 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.23 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.24 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.25 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.26 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.3 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.3 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.31 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.3 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.29 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.29 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.3 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.32 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.32 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.31 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.32 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.33 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.35 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.37 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.38 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.35 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.34 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.34 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.35 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.32 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.32 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.3 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.33 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
rplC 800648 c.-161A>T upstream_gene_variant 0.18 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.28 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.28 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.3 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.3 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.31 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.28 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.31 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.27 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.28 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.29 linezolid
rplC 800814 c.6A>G synonymous_variant 0.28 linezolid
rplC 800817 c.9A>T synonymous_variant 0.27 linezolid
rplC 800844 c.36T>C synonymous_variant 0.21 linezolid
rplC 800865 c.57A>G synonymous_variant 0.18 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.17 linezolid
rplC 801207 c.399C>T synonymous_variant 0.18 linezolid
rplC 801222 c.414T>C synonymous_variant 0.19 linezolid
Rv1129c 1254243 p.Glu98Lys missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303534 p.Ser202Ala missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303539 c.609G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303605 c.675C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303617 c.687C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303641 c.711C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303654 c.724C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303663 c.733C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303671 c.741C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1303681 c.751T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.25 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303866 p.Glu312Asp missense_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303944 c.1014G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303953 p.Asp341Glu missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303956 c.1026A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303971 c.1041T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>A synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303998 c.1068T>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304004 c.1074A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078_1080delTTGinsCTC synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304022 c.1092T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304031 c.1101C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Asp missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.19 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.29 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1305030 c.2100G>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1305063 c.2133G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1305066 c.2136T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305069 c.2139G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1305075 c.2145T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305078 c.2148A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305081 c.2151G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305090 c.2160C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305092 p.Ala721Gly missense_variant 0.18 pretomanid
delamanid
clofazimine
sigE 1364388 c.-25A>G upstream_gene_variant 1.0 pyrazinamide
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 0.99 ethambutol
atpE 1461113 c.69C>T synonymous_variant 0.16 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.19 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.19 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.19 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.19 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.19 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.19 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.17 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.17 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.34 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473417 n.-241C>T upstream_gene_variant 0.18 capreomycin
linezolid
rrl 1473419 n.-239T>C upstream_gene_variant 0.17 capreomycin
linezolid
rrl 1473420 n.-238A>G upstream_gene_variant 0.17 capreomycin
linezolid
rrl 1473421 n.-237G>A upstream_gene_variant 0.17 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473938 n.281G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473939 n.282C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324G>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.4 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474044 n.387C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476717 n.3060C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
inhA 1673547 c.-655T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673568 c.-634C>G upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1673574 c.-628C>G upstream_gene_variant 0.3 isoniazid
ethionamide
inhA 1673580 c.-622T>G upstream_gene_variant 0.29 isoniazid Uncertain significance
ethionamide
inhA 1673589 c.-613A>G upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1673591 c.-611C>T upstream_gene_variant 0.27 isoniazid Uncertain significance
ethionamide
inhA 1673595 c.-607A>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673596 c.-606A>G upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673602 c.-600C>T upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673607 c.-595T>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673615 c.-587_-586delAAinsTG upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673619 c.-583T>C upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673633 c.-569G>A upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673637 c.-565C>G upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673641 c.-561G>A upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673646 c.-556T>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673657 c.-545C>A upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673660 c.-542C>A upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673664 c.-538A>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673667 c.-535A>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673679 c.-523T>C upstream_gene_variant 0.18 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673985 c.-217C>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1674006 c.-196T>G upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.18 isoniazid
ethionamide
inhA 1674601 p.Leu134Thr missense_variant 0.19 isoniazid
ethionamide
inhA 1674672 c.471C>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674746 p.Tyr182Phe missense_variant 0.18 isoniazid
ethionamide
inhA 1674750 c.549T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674753 c.552G>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674789 c.588G>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674795 c.594G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674816 c.615T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674822 c.621C>G synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674828 c.627G>A synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.17 isoniazid
ethionamide
inhA 1674864 c.663C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674888 c.687C>G synonymous_variant 0.16 isoniazid
ethionamide
rpsA 1833661 c.120A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.31 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.2 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.29 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834609 c.1068T>A synonymous_variant 0.28 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.3 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.27 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.26 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.26 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.25 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.21 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.23 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.19 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.25 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.22 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.22 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.2 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.2 linezolid
tsnR 1853444 c.-162C>G upstream_gene_variant 0.17 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.17 linezolid
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
bacA 2064978 c.-250G>C upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101830 p.Ile405Val missense_variant 0.2 isoniazid
delamanid
ethionamide
ndh 2101837 p.Ala402Val missense_variant 0.19 isoniazid Uncertain significance
delamanid
ethionamide Uncertain significance
ndh 2101872 p.Ile391Phe missense_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2101873 p.Phe390Leu missense_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2101885 c.1158G>A synonymous_variant 0.2 isoniazid
delamanid
ethionamide
ndh 2101888 c.1155T>C synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2101894 c.1149T>G synonymous_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2101912 c.1131G>C synonymous_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2101920 c.1123A>C synonymous_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2101924 c.1119T>G synonymous_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2101939 c.1104A>G synonymous_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2102240 p.Arg268His missense_variant 0.9 isoniazid Not assoc w R - Interim
delamanid Uncertain significance
ethionamide Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155704 c.408C>G synonymous_variant 0.16 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.17 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.2 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.2 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.2 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.2 isoniazid
katG 2155782 c.330C>G synonymous_variant 0.17 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.17 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168742 p.Gly624Asp missense_variant 0.99 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 0.99 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223553 c.-389C>A upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Not assoc w R
pncA 2289987 c.-746C>T upstream_gene_variant 0.17 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.16 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.18 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.18 pyrazinamide
pncA 2290024 c.-783C>G upstream_gene_variant 0.18 pyrazinamide
pncA 2290030 c.-791_-789delAATinsCAC upstream_gene_variant 0.17 pyrazinamide
pncA 2290033 c.-792C>G upstream_gene_variant 0.17 pyrazinamide
pncA 2290038 c.-797G>A upstream_gene_variant 0.16 pyrazinamide
pncA 2290042 c.-801T>C upstream_gene_variant 0.16 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.22 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.16 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.15 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.17 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.17 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.19 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.2 isoniazid
kasA 2518263 p.Phe50Tyr missense_variant 0.15 isoniazid
kasA 2518265 p.Val51Ile missense_variant 0.15 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.16 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.17 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.17 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.2 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.22 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.19 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.18 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.18 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.18 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.19 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.19 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.19 isoniazid
kasA 2518597 c.483C>T synonymous_variant 0.22 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.25 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.2 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.2 isoniazid
kasA 2518663 c.549T>G synonymous_variant 0.18 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.21 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.2 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.18 isoniazid
kasA 2518694 p.Val194Ile missense_variant 0.79 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.17 isoniazid
kasA 2518714 c.600A>G synonymous_variant 0.19 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.24 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.22 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.2 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.21 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.19 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.18 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.17 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.19 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.2 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.17 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.18 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.18 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.17 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.17 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.16 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.17 isoniazid
kasA 2519104 c.990T>C synonymous_variant 0.17 isoniazid
kasA 2519108 p.Asp332His missense_variant 0.17 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.18 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.17 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 0.99 isoniazid
ahpC 2726162 c.-31T>C upstream_gene_variant 1.0 isoniazid
folC 2747338 c.261C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.19 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.2 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.2 para-aminosalicylic_acid
Rv2477c 2782847 p.Arg399Lys missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.19 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782894 c.1149C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.24 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.3 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.3 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.32 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783290 c.753G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783601 c.442C>T synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.37 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2752c 3064905 c.1287C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3066432 c.-241T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066436 c.-246_-245delGGinsAA upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066452 c.-261T>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066456 c.-265A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066462 c.-271G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066465 c.-276_-274delGGGinsAAT upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066471 c.-280A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066476 c.-285C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066704 c.-513C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066707 c.-516A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066713 c.-522C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066714 c.-523G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066748 c.-558_-557delCAinsAT upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066758 c.-567C>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067252 p.Val232Met missense_variant 0.16 para-aminosalicylic_acid
thyX 3067274 c.672C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067277 c.669C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067281 p.Val222Ala missense_variant 0.17 para-aminosalicylic_acid
thyX 3067284 p.Ala221Ser missense_variant 0.18 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067292 c.654G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.24 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067487 c.459G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067510 c.436C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.18 para-aminosalicylic_acid
thyX 3067517 c.429C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.23 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.23 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.22 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.23 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.19 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.18 para-aminosalicylic_acid
thyX 3067571 c.375C>T synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067600 p.Val116Ile missense_variant 0.22 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.22 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.28 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067676 c.270C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067691 p.Ile85Val missense_variant 0.3 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.21 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067826 c.120C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067849 p.Pro33Ser missense_variant 0.17 para-aminosalicylic_acid
thyX 3067850 c.96A>T synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067877 c.69G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.18 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.18 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623484 p.Phe476Tyr missense_variant 0.18 rifampicin
bedaquiline
lpqB 3623492 c.1419T>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3623512 p.Gly467Ser missense_variant 0.21 rifampicin
bedaquiline
lpqB 3623528 c.1383G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3623531 c.1380T>C synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624014 c.897T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624023 c.888G>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624026 p.Glu295Asp missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624030 p.Ala294Arg missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624032 c.879T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624037 c.874A>C synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624041 p.Glu290Asp missense_variant 0.18 rifampicin
bedaquiline
lpqB 3624050 c.861C>G synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624077 c.834G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624673 p.Ala80Ser missense_variant 0.16 rifampicin
bedaquiline
lpqB 3624680 c.231T>A synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624686 p.Glu75Gln missense_variant 0.18 rifampicin
bedaquiline
lpqB 3624701 c.210T>C synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624704 c.207G>C synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624707 c.204G>C synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.26 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624755 c.154_156delTTAinsCTG synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624770 c.141T>C synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624776 c.135T>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624783 p.Ser43Thr missense_variant 0.2 rifampicin
bedaquiline
lpqB 3624788 c.123A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625117 c.-207T>G upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625123 c.-213T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625134 c.-224T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625135 c.1479A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625141 c.-231T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625149 p.Val489Ile missense_variant 0.19 rifampicin
bedaquiline
mtrB 3625162 c.1452T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625186 c.-276T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625189 c.1425A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625195 c.-285A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625201 c.-291T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625510 c.-600T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625513 c.-603G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625518 c.-608T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625525 c.-615G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625528 c.-618G>T upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625537 c.-627T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.36 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.37 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.39 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.4 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.4 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.36 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.35 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.34 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.34 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.37 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.38 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.42 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626157 p.Ala153Ser missense_variant 0.15 rifampicin
bedaquiline
mtrB 3626467 c.147G>A synonymous_variant 0.97 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626900 c.-287G>A upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.48 rifampicin
bedaquiline
mtrB 3626945 c.-332C>T upstream_gene_variant 0.49 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.52 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627146 c.204C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.19 rifampicin
bedaquiline
rpoA 3877553 p.Glu319Gln missense_variant 0.21 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.23 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.29 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.22 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.2 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.29 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.3 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.3 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.27 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.27 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.26 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.26 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.25 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.25 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.22 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.25 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.25 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.25 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.25 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.25 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.24 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.24 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.24 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.23 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.23 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.24 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>G synonymous_variant 0.24 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.24 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.24 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.24 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.23 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.23 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.24 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.25 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.29 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.29 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.29 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.32 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.34 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.3 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.28 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.28 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.25 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.27 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.25 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.24 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.26 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.29 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.3 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.3 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.27 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.26 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.25 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.25 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.23 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.19 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.19 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.23 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.23 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.22 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.21 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.22 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.21 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.3 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.32 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.29 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.27 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.25 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.17 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.19 pretomanid
delamanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.16 pretomanid
delamanid
clpC1 4038302 c.2403C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038314 c.2391T>G synonymous_variant 0.18 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038374 c.2331C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.23 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.22 pyrazinamide
clpC1 4038458 c.2247G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038461 c.2244G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.25 pyrazinamide
clpC1 4038491 c.2214C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038497 p.Ser736Thr missense_variant 0.25 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.25 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.25 pyrazinamide
clpC1 4038575 c.2130C>A synonymous_variant 0.25 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.3 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.28 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.29 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.34 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.25 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.23 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039031 c.1674T>A synonymous_variant 0.23 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.27 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.17 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039409 c.1296T>A synonymous_variant 0.18 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039481 c.1224T>A synonymous_variant 0.19 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Pro missense_variant 0.24 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.18 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.16 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.22 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040297 c.408G>A synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040318 c.387C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.17 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040517 p.Val63Ala missense_variant 0.87 pyrazinamide Not assoc w R - Interim
clpC1 4040719 c.-15A>G upstream_gene_variant 0.99 pyrazinamide Uncertain significance
panD 4044695 c.-414C>T upstream_gene_variant 0.87 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.16 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.19 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.2 pyrazinamide
panD 4044746 c.-467_-465delGTGinsATC upstream_gene_variant 0.19 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.19 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTTC upstream_gene_variant 0.17 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.2 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.21 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.2 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.19 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4139489 c.267G>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139537 c.219G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139541 p.Ile72Thr missense_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139545 c.211T>C synonymous_variant 0.31 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139552 p.Ala68Ser missense_variant 0.36 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139561 c.195G>A synonymous_variant 0.4 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139601 p.Arg52Gln missense_variant 0.3 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
embC 4240420 c.558T>G synonymous_variant 0.22 ethambutol
embC 4240424 p.Arg188Lys missense_variant 0.2 ethambutol
embC 4240432 c.570C>T synonymous_variant 0.19 ethambutol
embC 4240444 c.582C>G synonymous_variant 0.21 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.17 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.2 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.21 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.26 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.27 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.26 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.23 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.24 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.21 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.17 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.81 ethambutol Not assoc w R
embC 4241047 c.1185C>G synonymous_variant 0.18 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.18 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.18 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.17 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.21 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.19 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.19 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.17 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.17 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.22 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.22 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.26 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.27 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.27 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.28 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.27 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.28 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.28 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.27 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>G synonymous_variant 0.28 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.27 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.27 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.27 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.27 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.31 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.31 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.26 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.22 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.21 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.18 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
embA 4242754 c.-479G>C upstream_gene_variant 0.17 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.19 ethambutol
embA 4242772 c.-461G>C upstream_gene_variant 0.2 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.21 ethambutol
embC 4242791 p.Ala977Ser missense_variant 0.19 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.18 ethambutol
embA 4242820 c.-413G>C upstream_gene_variant 0.18 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.18 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.18 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.18 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embA 4242844 c.-389A>G upstream_gene_variant 0.18 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.18 ethambutol
embA 4242859 c.-374C>T upstream_gene_variant 0.16 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.16 ethambutol
embA 4244611 p.Ala460Gly missense_variant 0.16 ethambutol
embA 4245053 c.1821G>C synonymous_variant 0.17 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.19 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.24 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.27 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.25 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.33 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.36 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.36 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.35 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.38 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.36 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.35 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.32 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.31 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.26 ethambutol
embA 4245248 c.2016G>C synonymous_variant 0.27 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.25 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embA 4246306 p.Ser1025* stop_gained 0.16 ethambutol Uncertain significance
embB 4247425 c.912G>C synonymous_variant 0.19 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.2 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.2 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.2 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.22 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.24 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.24 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.24 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.24 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.2 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.19 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.16 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247761 c.1248T>C synonymous_variant 0.17 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.18 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.18 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.24 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.24 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.25 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.27 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.28 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.33 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.31 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.31 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.31 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.31 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.29 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.27 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.26 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.24 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.24 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.25 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.19 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.16 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.18 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.18 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.17 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.19 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.19 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.19 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.2 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.24 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.28 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.34 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.34 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.23 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.2 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.19 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.18 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.18 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.19 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.18 ethambutol
embB 4248382 c.1869C>G synonymous_variant 0.2 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.18 ethambutol
embB 4249444 c.2931T>C synonymous_variant 0.19 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.24 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.23 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.22 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.17 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.17 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.16 ethambutol Uncertain significance
embB 4249543 c.3030G>C synonymous_variant 0.17 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.16 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.15 ethambutol
aftB 4267960 p.Val293Met missense_variant 0.99 ethambutol Uncertain significance
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326148 c.1326G>T synonymous_variant 1.0 ethionamide Not assoc w R - Interim
ethA 4326439 p.Asn345Lys missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338203 p.Arg107Cys missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407848 p.Ala119Thr missense_variant 1.0 streptomycin Uncertain significance
gid 4407873 c.330G>T synonymous_variant 0.99 streptomycin Not assoc w R