TB-Profiler result

Run: ERR4816470
Summary

Run ID: ERR4816470

Sample name:

Date: 2024-04-15T02:03:38.085419

Number of reads: 564431

Percentage reads mapped: 22.31

Median coverage: 14.0

Strain: lineage3

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.421_423delTTGinsCC Assoc w R High-level resistance
c.346_348delCACinsGG Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155689 c.421_423delTTGinsCC frameshift_variant&missense_variant 0.6 isoniazid Assoc w R High-level resistance
katG 2155764 c.346_348delCACinsGG frameshift_variant&missense_variant 0.53 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 609 c.609C>G synonymous_variant 0.48 isoniazid
dnaA 624 c.624C>T synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 645 c.645A>T synonymous_variant 0.49 isoniazid
dnaA 654 c.654A>G synonymous_variant 0.46 isoniazid
dnaA 660 c.660G>A synonymous_variant 0.47 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.47 isoniazid
dnaA 666 c.666C>G synonymous_variant 0.46 isoniazid
dnaA 667 p.Asn223His missense_variant 0.46 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.46 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.47 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>A synonymous_variant 0.47 isoniazid
dnaA 682 c.682T>C synonymous_variant 0.47 isoniazid
dnaA 693 c.693A>T synonymous_variant 0.5 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.5 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.49 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.52 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.42 isoniazid
dnaA 753 c.753C>T synonymous_variant 0.42 isoniazid
gyrA 6742 c.-560A>G upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 p.Ala504Ser missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 6763 c.-539G>A upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrB 6764 c.1525_1527delCTGinsTC frameshift_variant&missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.63 levofloxacin
moxifloxacin
gyrB 6798 p.Gly520Ala missense_variant 0.67 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6811 c.1572C>T synonymous_variant 0.67 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6856 c.1617T>C synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrB 6881 c.1642T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6889 c.-413G>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrB 6896 p.Arg553Lys missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>T upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6922 c.1683G>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6924 p.Phe562Tyr missense_variant 0.44 levofloxacin
moxifloxacin
gyrB 6926 c.1687T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
nusG 734443 p.Ala64Thr missense_variant 0.47 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.68 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.7 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.8 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
nusG 734484 c.231C>T synonymous_variant 0.83 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.79 rifampicin
nusG 734505 c.252G>C synonymous_variant 0.83 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.83 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
nusG 734543 p.Arg97Gln missense_variant 0.71 rifampicin
nusG 734548 p.Gln99Lys missense_variant 0.71 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.76 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.7 rifampicin
nusG 734596 c.343_345delTTGinsCC frameshift_variant&missense_variant 0.61 rifampicin
nusG 734600 p.Thr116Asn missense_variant 0.59 rifampicin Uncertain significance
nusG 734607 p.Asp118Glu missense_variant 0.56 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.56 rifampicin
nusG 734615 p.Ala121Gly missense_variant 0.56 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.56 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.54 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760088 c.282C>G synonymous_variant 0.46 rifampicin
rpoB 760091 c.285G>T synonymous_variant 0.46 rifampicin
rpoB 760101 c.295_297delTTGinsCT frameshift_variant&synonymous_variant 0.44 rifampicin
rpoB 760106 c.300G>C synonymous_variant 0.42 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.48 rifampicin
rpoB 760120 p.Arg105His missense_variant 0.5 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.6 rifampicin Uncertain significance
rpoB 760139 c.333A>C synonymous_variant 0.6 rifampicin
rpoB 760140 p.Pro112Ser missense_variant 0.59 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.62 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.7 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.69 rifampicin
rpoB 760184 c.378A>C synonymous_variant 0.7 rifampicin
rpoB 760199 c.393C>G synonymous_variant 0.69 rifampicin
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.6 rifampicin
rpoB 760241 c.435G>C synonymous_variant 0.59 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760265 p.Met153Ile missense_variant 0.56 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.54 rifampicin Uncertain significance
rpoB 760282 p.Thr159Ser missense_variant 0.44 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760368 p.Ser188Ala missense_variant 0.35 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.36 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.42 rifampicin
rpoB 760385 c.579G>C synonymous_variant 0.42 rifampicin
rpoB 760390 p.Ser195Thr missense_variant 0.46 rifampicin
rpoB 760394 c.588C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760400 c.594G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760407 p.Ser201Gly missense_variant 0.58 rifampicin Uncertain significance
rpoB 760412 c.606C>T synonymous_variant 0.58 rifampicin
rpoB 760418 c.612G>A synonymous_variant 0.57 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760427 c.621G>A synonymous_variant 0.57 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>A synonymous_variant 0.56 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>T synonymous_variant 0.48 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.47 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.61 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.61 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760940 c.1134G>C synonymous_variant 0.63 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760958 c.1152G>T synonymous_variant 0.65 rifampicin
rpoB 760964 c.1158C>A synonymous_variant 0.65 rifampicin
rpoB 760965 c.1159_1161delATGinsCC frameshift_variant&missense_variant 0.65 rifampicin
rpoB 760973 c.1167G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761003 c.1197C>G synonymous_variant 0.57 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>G synonymous_variant 0.35 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.48 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761240 c.1434C>T synonymous_variant 0.51 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.46 rifampicin
rpoB 761300 c.1494G>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761930 c.2124G>A synonymous_variant 0.41 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.53 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.51 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.51 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.55 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>G synonymous_variant 0.55 rifampicin
rpoB 762101 c.2295C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.51 rifampicin Uncertain significance
rpoB 762128 c.2322G>C synonymous_variant 0.51 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.53 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.55 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762161 c.2355C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.52 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 0.6 rifampicin Not assoc w R
rpoB 762795 p.Asp997Asn missense_variant 0.33 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.35 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762818 c.3012C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762827 c.-543G>T upstream_gene_variant 0.41 rifampicin
rpoC 762830 c.-540C>T upstream_gene_variant 0.41 rifampicin
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762858 c.3052_3054delACGinsTT frameshift_variant&missense_variant 0.41 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762881 p.Met1025Ile missense_variant 0.6 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 762917 c.-453C>T upstream_gene_variant 0.7 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.75 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.77 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763022 c.-348C>G upstream_gene_variant 0.77 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.21 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.76 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.74 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.7 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>C upstream_gene_variant 0.37 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.29 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.62 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763619 p.Arg84Lys missense_variant 0.66 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.56 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.52 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.52 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.62 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.72 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.75 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.79 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.79 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.72 rifampicin
rpoC 763768 c.399C>A synonymous_variant 0.72 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.72 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.69 rifampicin
rpoC 763796 c.427_429delATGinsCC frameshift_variant&missense_variant 0.62 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.62 rifampicin
rpoC 764134 c.765C>A synonymous_variant 0.48 rifampicin
rpoC 764143 c.774G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.52 rifampicin Uncertain significance
rpoC 764153 p.Gln262Lys missense_variant 0.52 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.46 rifampicin
rpoC 764162 p.Ile265Leu missense_variant 0.46 rifampicin
rpoC 764169 p.Asn267Thr missense_variant 0.52 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.57 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.54 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.54 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.58 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.59 rifampicin
rpoC 764221 c.852C>T synonymous_variant 0.57 rifampicin
rpoC 764227 c.858G>T synonymous_variant 0.58 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.69 rifampicin
rpoC 764254 c.885G>A synonymous_variant 0.71 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.69 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.66 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.66 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.67 rifampicin
rpoC 764308 c.939G>C synonymous_variant 0.69 rifampicin
rpoC 764317 c.948C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764320 c.951C>G synonymous_variant 0.67 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.61 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.51 rifampicin
rpoC 764398 c.1029G>C synonymous_variant 0.44 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.56 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.53 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.51 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.54 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>T synonymous_variant 0.65 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.65 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764512 c.1143G>C synonymous_variant 0.67 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.81 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764602 c.1233C>T synonymous_variant 0.88 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.88 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764686 c.1317C>T synonymous_variant 0.76 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.72 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764764 p.His465Gln missense_variant 0.69 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.62 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764854 c.1485G>C synonymous_variant 0.58 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>T synonymous_variant 0.5 rifampicin
rpoC 764875 c.1506C>G synonymous_variant 0.49 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.47 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.57 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.54 rifampicin Uncertain significance
rpoC 764917 c.1548G>C synonymous_variant 0.54 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.55 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.62 rifampicin
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.62 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>T synonymous_variant 0.54 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765013 c.1644C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.54 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>G synonymous_variant 0.54 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.49 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.47 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.47 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.44 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.5 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.42 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765898 c.2529C>T synonymous_variant 0.39 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>C synonymous_variant 0.43 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.43 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.5 rifampicin
rpoC 766333 c.2964G>C synonymous_variant 0.6 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.56 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.59 rifampicin
rpoC 766361 c.2992_2994delGTGinsAC frameshift_variant&missense_variant 0.59 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.62 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.59 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.56 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.56 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.59 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.61 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766411 c.3042C>G synonymous_variant 0.6 rifampicin
rpoC 766435 p.Glu1022Asp missense_variant 0.57 rifampicin Uncertain significance
rpoC 766702 c.3333G>C synonymous_variant 0.39 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.39 rifampicin
rpoC 766711 c.3342C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766717 c.3348C>G synonymous_variant 0.44 rifampicin
rpoC 766718 p.Asp1117Asn missense_variant 0.44 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.44 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766799 p.Ala1144Ser missense_variant 0.38 rifampicin Uncertain significance
rpoC 766804 c.3435A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766835 p.Val1156Thr missense_variant 0.39 rifampicin
rpoC 766843 c.3474T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.45 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.45 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.42 rifampicin
rpoC 766909 c.3540G>C synonymous_variant 0.4 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.4 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.44 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.42 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.43 rifampicin
rpoC 766987 c.3618G>C synonymous_variant 0.5 rifampicin
rpoC 766990 c.3621G>C synonymous_variant 0.57 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>C synonymous_variant 0.58 rifampicin
rpoC 767017 c.3648C>G synonymous_variant 0.65 rifampicin
rpoC 767023 p.Asp1218Glu missense_variant 0.67 rifampicin
rpoC 767026 c.3657G>C synonymous_variant 0.67 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.71 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.69 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767087 p.Cys1240Ser missense_variant 0.72 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.69 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767155 c.3786C>G synonymous_variant 0.42 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777668 p.Ile271Met missense_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781670 c.111G>C synonymous_variant 0.3 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.35 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.33 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.33 streptomycin
rpsL 781709 c.150G>T synonymous_variant 0.33 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.33 streptomycin
rpsL 781725 p.Lys56Arg missense_variant 0.35 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.35 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.38 streptomycin
rpsL 781737 p.Gln60Ser missense_variant 0.38 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.44 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.44 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.44 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.44 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.47 streptomycin Not assoc w R - Interim
rpsL 781769 c.210G>A synonymous_variant 0.5 streptomycin
rpsL 781781 c.222G>C synonymous_variant 0.55 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.55 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.39 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.39 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.42 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.46 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.4 streptomycin
rpsL 781845 p.Lys96Arg missense_variant 0.35 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.36 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.35 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.35 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.32 streptomycin
rplC 800516 c.-293G>C upstream_gene_variant 0.3 linezolid
rplC 800531 c.-278T>C upstream_gene_variant 0.41 linezolid
rplC 800537 c.-272C>G upstream_gene_variant 0.46 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.5 linezolid
rplC 800564 c.-245C>G upstream_gene_variant 0.56 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.56 linezolid
rplC 800573 c.-236C>G upstream_gene_variant 0.53 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.52 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.52 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.53 linezolid
rplC 800588 c.-221C>A upstream_gene_variant 0.52 linezolid
rplC 800589 c.-220A>C upstream_gene_variant 0.52 linezolid
rplC 800597 c.-212A>C upstream_gene_variant 0.5 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.5 linezolid
rplC 800610 c.-199_-197delCTAinsTG upstream_gene_variant 0.49 linezolid
rplC 800615 c.-194G>T upstream_gene_variant 0.49 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.5 linezolid
rplC 800621 c.-188G>A upstream_gene_variant 0.47 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.55 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.52 linezolid
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.39 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.36 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.37 linezolid
rplC 800693 c.-116A>T upstream_gene_variant 0.35 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.35 linezolid
rplC 800703 c.-106_-104delTTGinsCC upstream_gene_variant 0.35 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.34 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.34 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.34 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.37 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.36 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80delTinsCAG non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471929 n.84C>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471930 n.85G>C non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471931 n.86G>T non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471980 n.135G>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1471981 n.136C>G non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472288 n.443A>T non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472326 n.481T>A non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601dupT non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472449 n.604_607delCACGinsGCA non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>A non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472846 n.1001_1002insA non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1005delT non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472960 n.1115G>A non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472986 n.1141C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.99 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.99 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTG non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473731 n.74T>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473732 n.75G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1473750 n.93C>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473811 n.154C>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1473812 n.155G>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_172insCT non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1473835 n.179delA non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1474627 n.970G>C non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474721 n.1064G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474722 n.1065T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475059 n.1404_1405delCA non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475064 n.1407G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475067 n.1410_1411insG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475080 n.1423G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475081 n.1424C>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101delAinsGTT non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475762 n.2106_2108delCAA non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476029 n.2373_2377delACCTC non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.98 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rpsA 1833664 c.123C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.67 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833682 c.141C>T synonymous_variant 0.65 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.7 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.74 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.78 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.78 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.76 pyrazinamide
rpsA 1833734 c.193_195delGCCinsTT frameshift_variant&missense_variant 0.76 pyrazinamide Uncertain significance
rpsA 1833748 c.207C>G synonymous_variant 0.79 pyrazinamide
rpsA 1833770 p.Asn77Ser missense_variant 0.79 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.79 pyrazinamide
rpsA 1833782 p.Ser81Asn missense_variant 0.79 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.82 pyrazinamide
rpsA 1833808 c.267G>T synonymous_variant 0.8 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.81 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.88 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.86 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.85 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.81 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.8 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.8 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.84 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.84 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.83 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.84 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.82 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.82 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.83 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.84 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.85 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.82 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.81 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.8 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.79 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.67 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.58 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834183 c.642T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834210 c.669C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834252 c.711C>T synonymous_variant 0.54 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.55 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
rpsA 1834282 c.741C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834298 p.Gln253Thr missense_variant 0.62 pyrazinamide
rpsA 1834318 c.777C>G synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
rpsA 1834327 c.786G>T synonymous_variant 0.73 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.73 pyrazinamide
rpsA 1834340 c.799_801delATGinsCC frameshift_variant&missense_variant 0.73 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>T synonymous_variant 0.79 pyrazinamide
rpsA 1834357 c.816T>G synonymous_variant 0.81 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.84 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.89 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.88 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.89 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.89 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.9 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.89 pyrazinamide
rpsA 1834483 p.Glu314Asp missense_variant 0.88 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.88 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.79 pyrazinamide
rpsA 1834543 c.1002C>T synonymous_variant 0.76 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.8 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.76 pyrazinamide
rpsA 1834612 c.1071G>T synonymous_variant 0.76 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.75 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.78 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.73 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.69 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834756 p.Glu405Asp missense_variant 0.6 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.58 pyrazinamide
rpsA 1834761 p.Phe407Tyr missense_variant 0.58 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.58 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.58 pyrazinamide
rpsA 1834813 c.1272G>C synonymous_variant 0.57 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
ndh 2103191 c.-149G>A upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2155659 c.453C>G synonymous_variant 0.56 isoniazid
katG 2155671 c.441G>C synonymous_variant 0.64 isoniazid
katG 2155674 c.438G>A synonymous_variant 0.64 isoniazid
katG 2155677 c.435C>A synonymous_variant 0.64 isoniazid
katG 2155680 c.432G>A synonymous_variant 0.64 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.56 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.58 isoniazid
katG 2155719 c.393G>T synonymous_variant 0.58 isoniazid
katG 2155722 c.390G>T synonymous_variant 0.61 isoniazid
katG 2155728 c.384G>T synonymous_variant 0.56 isoniazid
katG 2155737 c.375C>A synonymous_variant 0.5 isoniazid
katG 2155741 p.Gly124Thr missense_variant 0.5 isoniazid
katG 2155743 c.369G>A synonymous_variant 0.47 isoniazid Not assoc w R - Interim
katG 2155749 c.363C>A synonymous_variant 0.5 isoniazid
katG 2155755 c.357C>T synonymous_variant 0.5 isoniazid Not assoc w R - Interim
katG 2155769 p.Ile115Val missense_variant 0.53 isoniazid
katG 2155782 c.330C>G synonymous_variant 0.53 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.53 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2221732 p.Pro478Gln missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.7 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
ahpC 2726561 c.369T>C synonymous_variant 0.43 isoniazid
ahpC 2726564 c.372C>T synonymous_variant 0.5 isoniazid Not assoc w R - Interim
ahpC 2726576 c.384C>T synonymous_variant 0.55 isoniazid
ahpC 2726579 c.387T>C synonymous_variant 0.59 isoniazid
ahpC 2726582 c.390G>C synonymous_variant 0.64 isoniazid
ahpC 2726588 c.396C>T synonymous_variant 0.7 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.7 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.69 isoniazid
ahpC 2726604 p.Val138Ile missense_variant 0.71 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.79 isoniazid
ahpC 2726651 c.459G>T synonymous_variant 0.76 isoniazid
ahpC 2726654 c.462G>C synonymous_variant 0.76 isoniazid Not assoc w R - Interim
ahpC 2726657 c.465A>C synonymous_variant 0.76 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.75 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.78 isoniazid
ahpC 2726681 c.489A>T synonymous_variant 0.75 isoniazid
ahpC 2726684 c.492G>T synonymous_variant 0.78 isoniazid
ahpC 2726693 c.501C>A synonymous_variant 0.78 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.74 isoniazid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625687 c.927G>A synonymous_variant 0.55 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625711 c.-801C>A upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3625721 p.Arg298Gln missense_variant 0.62 bedaquiline
rifampicin Uncertain significance
lpqB 3625723 c.-813C>A upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 p.Asn294Gly missense_variant 0.58 bedaquiline
rifampicin
lpqB 3625735 c.-825C>T upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3625747 c.867G>C synonymous_variant 0.6 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 p.Gln288His missense_variant 0.58 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.62 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 p.Arg284Lys missense_variant 0.65 bedaquiline
rifampicin
lpqB 3625770 c.-860C>T upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrB 3625797 p.Val273Met missense_variant 0.54 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625798 c.-888G>C upstream_gene_variant 0.54 bedaquiline
rifampicin
lpqB 3625803 c.-893C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.5 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627011 c.-398T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627014 c.-401G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627017 c.-404G>A upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrA 3627038 c.310_312delATGinsGC frameshift_variant&missense_variant 0.43 bedaquiline
rifampicin
mtrA 3627041 p.Ile103Met missense_variant 0.43 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrA 3627068 c.282T>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627077 c.-464G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627094 p.Thr86Ser missense_variant 0.38 bedaquiline
rifampicin
mtrB 3627098 c.-485A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627101 c.-488C>A upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627104 c.-491C>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627125 c.-512C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627134 c.-521C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877560 c.948C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.56 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877599 p.Gln303Thr missense_variant 0.59 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.69 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 0.73 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.7 rifampicin
rpoA 3877665 c.843C>T synonymous_variant 0.66 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.65 rifampicin
rpoA 3877674 c.834C>T synonymous_variant 0.67 rifampicin
rpoA 3877680 c.828G>T synonymous_variant 0.67 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877701 c.807G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.7 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.69 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.7 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.71 rifampicin
rpoA 3877749 c.759C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.7 rifampicin
rpoA 3877765 p.Ala248Ser missense_variant 0.67 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>T synonymous_variant 0.67 rifampicin
rpoA 3877791 c.717C>G synonymous_variant 0.64 rifampicin
rpoA 3877794 c.714G>T synonymous_variant 0.64 rifampicin
rpoA 3877815 c.693C>A synonymous_variant 0.65 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877821 c.687C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>T synonymous_variant 0.67 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.66 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.61 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.59 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.56 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877896 c.610_612delCCGinsGT frameshift_variant&missense_variant 0.55 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.46 rifampicin
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.46 rifampicin
rpoA 3877935 p.Lys191Arg missense_variant 0.47 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.5 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.5 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.32 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>G synonymous_variant 0.31 rifampicin
rpoA 3878214 c.294C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878217 c.289_291delCTAinsGG frameshift_variant&missense_variant 0.36 rifampicin
rpoA 3878220 c.288C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878244 c.264G>A synonymous_variant 0.37 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.36 rifampicin
rpoA 3878251 c.256_257delTCinsAG synonymous_variant 0.38 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.36 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878298 c.210A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.24 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.23 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3879079 c.-572A>G upstream_gene_variant 0.35 rifampicin
rpoA 3879082 c.-575C>A upstream_gene_variant 0.38 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.38 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879097 c.-590C>A upstream_gene_variant 0.39 rifampicin
rpoA 3879121 c.-615_-614delTTinsAG upstream_gene_variant 0.39 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.39 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.39 rifampicin
rpoA 3879150 c.-643G>T upstream_gene_variant 0.39 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.38 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879181 c.-676_-674delAAGinsCGT upstream_gene_variant 0.3 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.37 rifampicin
rpoA 3879202 c.-695T>A upstream_gene_variant 0.39 rifampicin
rpoA 3879207 c.-700G>A upstream_gene_variant 0.38 rifampicin
clpC1 4038725 c.1980C>G synonymous_variant 0.61 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.61 pyrazinamide
clpC1 4038743 c.1962G>C synonymous_variant 0.61 pyrazinamide
clpC1 4038746 c.1959C>T synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4038749 c.1956C>T synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>C synonymous_variant 0.71 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.76 pyrazinamide
clpC1 4038770 c.1935C>A synonymous_variant 0.76 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.81 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.84 pyrazinamide
clpC1 4038810 p.Gln632Ser missense_variant 0.82 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038815 c.1890G>A synonymous_variant 0.85 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.86 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.81 pyrazinamide
clpC1 4038902 c.1803C>T synonymous_variant 0.81 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.81 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.83 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.8 pyrazinamide
clpC1 4038926 c.1779G>T synonymous_variant 0.79 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.78 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.78 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.78 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.76 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.77 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4038986 p.Asp573Glu missense_variant 0.78 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.78 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4039007 c.1698G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039019 c.1686G>C synonymous_variant 0.77 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.78 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.8 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.8 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.78 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.78 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.77 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.77 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.75 pyrazinamide
clpC1 4039139 c.1566G>A synonymous_variant 0.73 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.73 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.71 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.7 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCC frameshift_variant&missense_variant 0.65 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.66 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.65 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039244 c.1461G>T synonymous_variant 0.44 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039603 p.Ala368Thr missense_variant 0.69 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.74 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.66 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.64 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.62 pyrazinamide
clpC1 4039697 c.1008C>A synonymous_variant 0.66 pyrazinamide
clpC1 4039721 c.984C>T synonymous_variant 0.68 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.68 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.67 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.35 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039802 c.903G>A synonymous_variant 0.47 pyrazinamide
clpC1 4039811 c.894C>A synonymous_variant 0.57 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.57 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.57 pyrazinamide
clpC1 4039832 c.873C>A synonymous_variant 0.57 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.74 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039916 c.789T>C synonymous_variant 0.7 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.63 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.63 pyrazinamide
clpC1 4039937 c.768G>T synonymous_variant 0.63 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.63 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.59 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.56 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.56 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.52 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.5 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.56 pyrazinamide
clpC1 4040062 p.Ile215Val missense_variant 0.6 pyrazinamide Uncertain significance
clpC1 4040066 c.639G>T synonymous_variant 0.39 pyrazinamide
clpC1 4040069 c.636G>T synonymous_variant 0.4 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.45 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.47 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.47 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.6 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.72 pyrazinamide
clpC1 4040432 c.271_273delAGCinsTCG synonymous_variant 0.7 pyrazinamide
clpC1 4040437 c.268C>T synonymous_variant 0.71 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.75 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.75 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.75 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>G synonymous_variant 0.78 pyrazinamide
clpC1 4040495 c.210C>T synonymous_variant 0.8 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.79 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.81 pyrazinamide
clpC1 4040540 c.165G>C synonymous_variant 0.76 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4040552 c.153G>T synonymous_variant 0.67 pyrazinamide
clpC1 4040563 p.Ser48Ala missense_variant 0.6 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.56 pyrazinamide
clpC1 4040582 c.123G>T synonymous_variant 0.56 pyrazinamide
clpC1 4040585 c.120A>G synonymous_variant 0.51 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.51 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.5 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.5 pyrazinamide
clpC1 4040603 c.102T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040606 c.99T>C synonymous_variant 0.5 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.41 pyrazinamide
clpC1 4040645 c.60C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.33 pyrazinamide
clpC1 4040657 c.48T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 0.53 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R