TB-Profiler result

Run: SRR3675232
Summary

Run ID: SRR3675232

Sample name:

Date: 2024-10-03T16:28:33.949676

Number of reads: 2011305

Percentage reads mapped: 74.49

Median coverage: 94.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.95
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.99
lineage4 Euro-American None 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 669 c.669C>T synonymous_variant 0.17 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.18 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.18 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.19 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.21 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.22 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.22 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.22 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.24 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCTC synonymous_variant 0.2 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.21 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.21 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.21 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.21 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.21 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.22 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.23 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.23 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.23 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.23 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.26 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.26 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.28 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.27 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.27 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.22 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.22 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.2 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.2 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.2 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.2 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.2 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.19 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.22 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.23 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.22 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.23 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.24 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.25 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.26 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.26 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.25 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.25 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.24 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.25 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.25 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.23 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.26 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.25 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.27 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.27 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.27 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.29 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.27 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.26 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.25 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.24 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.24 isoniazid
dnaA 1218 c.1218C>G synonymous_variant 0.26 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.27 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.27 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.26 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.27 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.3 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.32 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.28 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.29 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.29 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.29 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.27 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.28 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.28 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.28 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.25 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.22 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.19 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.18 isoniazid
gyrB 6196 c.957C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6797 p.Gly520Ser missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.17 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7075 c.-227T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7102 c.-200G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7216 c.1977G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7658 c.357A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7664 c.363T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7685 c.384G>A synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7688 c.387C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7775 c.474C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8391 p.Tyr364His missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8401 p.Asp367Ala missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCTA synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.25 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490948 p.Ser56Ala missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491043 c.261T>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Asp missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491151 c.369G>A synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491173 c.391C>A synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491591 p.Lys270Met missense_variant 0.92 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
mshA 575665 c.318G>A synonymous_variant 0.17 isoniazid
ethionamide
mshA 575674 c.327G>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575679 p.Asn111Ser missense_variant 0.81 isoniazid Not assoc w R
ethionamide Not assoc w R
mshA 575695 c.348C>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ethionamide
mshA 575701 c.354G>A synonymous_variant 0.22 isoniazid
ethionamide
mshA 575704 c.357T>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.17 isoniazid
ethionamide
mshA 575719 c.372C>T synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575752 c.405G>C synonymous_variant 0.2 isoniazid
ethionamide
mshA 575755 c.408G>A synonymous_variant 0.2 isoniazid
ethionamide
mshA 575756 c.409C>T synonymous_variant 0.2 isoniazid
ethionamide
mshA 575770 c.423G>A synonymous_variant 0.21 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.2 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575812 c.465C>T synonymous_variant 0.21 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575887 c.540G>C synonymous_variant 0.21 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.19 isoniazid
ethionamide
mshA 575896 c.549G>C synonymous_variant 0.18 isoniazid
ethionamide
ccsA 620288 p.Arg133Gln missense_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>T synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620310 c.420C>T synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620376 c.486G>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
Rv0565c 657269 p.Ser68Pro missense_variant 0.92 ethionamide Uncertain significance
hadA 732295 c.366G>C synonymous_variant 0.18 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.19 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.19 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.21 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.22 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.22 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.26 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.28 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.28 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.2 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.2 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.21 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.22 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.18 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.18 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760115 c.309C>T synonymous_variant 0.88 rifampicin Not assoc w R
rpoB 760130 p.Asp108Glu missense_variant 0.18 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.3 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.28 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.28 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.28 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.27 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.28 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.27 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.26 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.3 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.29 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.27 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.32 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.3 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.36 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.36 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.36 rifampicin
rpoB 760598 c.792C>A synonymous_variant 0.36 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.29 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.21 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.18 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.26 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.35 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.37 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.33 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.32 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.26 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.26 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.26 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.22 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.21 rifampicin
rpoB 761373 p.Val523His missense_variant 0.19 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.22 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.22 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.21 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.21 rifampicin
rpoB 761439 p.Asp545Lys missense_variant 0.21 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.2 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.2 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.2 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.2 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.22 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.22 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.24 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.25 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.25 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.27 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.31 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.24 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.25 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.25 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.25 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.24 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.26 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.28 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.29 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.28 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.26 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.24 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.23 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.2 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.21 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.2 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.19 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.2 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.19 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.19 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.25 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762032 c.2226C>T synonymous_variant 0.24 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.31 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.3 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.27 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.28 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.31 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.28 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.28 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.27 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.27 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.28 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.28 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.27 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.27 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.26 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.2 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.2 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.21 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.22 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.36 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.37 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.31 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.3 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.22 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.22 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.22 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.22 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.24 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.2 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.2 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.18 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.21 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.31 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.32 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.31 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.32 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.29 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.28 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.29 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.31 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.25 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763835 p.Ala156Met missense_variant 0.23 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.24 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.26 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.28 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.28 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.28 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.27 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.26 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.26 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.27 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.27 rifampicin
rpoC 763942 c.573C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.28 rifampicin
rpoC 763948 c.579G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763949 c.580C>A synonymous_variant 0.28 rifampicin
rpoC 763954 c.585C>G synonymous_variant 0.28 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.26 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.25 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.25 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.27 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.3 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.29 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.27 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.26 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.23 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.21 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.21 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.22 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.23 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.23 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.22 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.23 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.2 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.2 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.2 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.21 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.21 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.33 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.35 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.35 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.35 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.32 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.34 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.34 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.33 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.33 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.29 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.32 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.32 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.31 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.26 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.28 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.24 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.26 rifampicin
rpoC 765150 p.Gly594Glu missense_variant 0.96 rifampicin Not assoc w R
rpoC 765383 p.Met672Leu missense_variant 0.25 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.26 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.29 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.39 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.41 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.39 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.39 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.37 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.38 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.38 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.32 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.31 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.31 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.33 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.33 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.31 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.31 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.31 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.25 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.26 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.24 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.22 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.23 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.21 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.22 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.21 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.22 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.25 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.21 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.17 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.19 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.19 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.21 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.2 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.21 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.23 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.24 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.25 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.26 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.26 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.28 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.28 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.29 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.3 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.31 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.34 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.3 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.27 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.26 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.28 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.28 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.28 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.29 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.29 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.33 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.33 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.33 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.33 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.34 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.33 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.34 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.34 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.3 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.27 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.28 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.31 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.32 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.31 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.32 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.32 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.34 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766885 c.3516G>A synonymous_variant 0.35 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.36 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.38 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.37 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.36 rifampicin
rpoC 766987 c.3618G>C synonymous_variant 0.36 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.31 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.31 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.31 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.3 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.29 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.23 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.2 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.18 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.18 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.24 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.23 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.24 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.24 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.24 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.24 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.26 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.27 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.27 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.3 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.3 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.3 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.29 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.29 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.29 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.31 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.32 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.33 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.34 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.37 streptomycin Uncertain significance
rplC 801246 c.438C>T synonymous_variant 0.19 linezolid
rplC 801249 c.441T>C synonymous_variant 0.21 linezolid
rplC 801255 c.447C>T synonymous_variant 0.21 linezolid
rplC 801264 c.456C>T synonymous_variant 0.2 linezolid
rplC 801267 c.459A>T synonymous_variant 0.19 linezolid
rplC 801270 c.462T>C synonymous_variant 0.2 linezolid
rplC 801276 c.468G>C synonymous_variant 0.19 linezolid
rplC 801279 c.471G>A synonymous_variant 0.19 linezolid
rplC 801282 c.474G>C synonymous_variant 0.19 linezolid
rplC 801285 c.477G>C synonymous_variant 0.18 linezolid
rplC 801309 c.501C>G synonymous_variant 0.18 linezolid
rplC 801312 c.504G>C synonymous_variant 0.18 linezolid
rplC 801321 c.513C>T synonymous_variant 0.24 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.24 linezolid
rplC 801339 c.531T>C synonymous_variant 0.24 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.25 linezolid
rplC 801348 c.540T>G synonymous_variant 0.27 linezolid
rplC 801357 c.549T>C synonymous_variant 0.27 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.28 linezolid
rplC 801402 c.594T>C synonymous_variant 0.24 linezolid
rplC 801405 c.597T>C synonymous_variant 0.24 linezolid
rplC 801423 c.615G>C synonymous_variant 0.26 linezolid
rplC 801426 c.618C>G synonymous_variant 0.24 linezolid
rplC 801427 p.Met207Val missense_variant 0.24 linezolid
rplC 801438 c.630T>C synonymous_variant 0.24 linezolid
rplC 801442 p.Ile212Val missense_variant 0.24 linezolid
fbiC 1304742 c.1812T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.42 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.88 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
sigE 1364772 c.360G>C synonymous_variant 0.18 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.17 pyrazinamide
sigE 1364793 c.381C>T synonymous_variant 0.17 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.18 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.18 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.18 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.18 pyrazinamide
Rv1258c 1407079 c.261delC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.34 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
inhA 1673574 c.-628C>G upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673591 c.-611C>T upstream_gene_variant 0.17 isoniazid Uncertain significance
ethionamide
inhA 1673602 c.-600C>T upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673615 c.-587A>T upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673619 c.-583T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673641 c.-561G>A upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673657 c.-545C>A upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673710 c.-492C>A upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673733 c.-469G>C upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673748 c.-454A>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1674816 c.615T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674822 c.621C>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674828 c.627G>A synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.2 isoniazid
ethionamide
inhA 1674864 c.663C>T synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674888 c.687C>G synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.22 isoniazid
ethionamide
inhA 1674909 c.708G>A synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674939 c.738G>A synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674942 c.741T>G synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674949 c.748C>T synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674954 c.753G>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674960 c.759C>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674966 c.765T>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674967 p.Asp256Thr missense_variant 0.19 isoniazid
ethionamide
inhA 1674987 c.786C>T synonymous_variant 0.16 isoniazid
ethionamide
rpsA 1833721 c.180A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.28 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.2 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.28 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.37 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.27 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.19 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.18 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.19 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.22 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.2 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.2 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.18 isoniazid
kasA 2518031 c.-84G>T upstream_gene_variant 0.15 isoniazid
kasA 2518059 c.-56T>A upstream_gene_variant 0.16 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518089 c.-26C>A upstream_gene_variant 0.16 isoniazid
kasA 2518094 c.-21G>A upstream_gene_variant 0.16 isoniazid
kasA 2518103 c.-12G>A upstream_gene_variant 0.19 isoniazid
kasA 2518106 c.-9C>G upstream_gene_variant 0.17 isoniazid
kasA 2518110 c.-5T>A upstream_gene_variant 0.16 isoniazid
kasA 2518121 p.Gln3Lys missense_variant 0.18 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.18 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.18 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.21 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.22 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.21 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.19 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.19 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.19 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.2 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.19 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.22 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.22 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.27 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.26 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.27 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.27 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.28 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.27 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.27 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.27 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.26 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.26 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.28 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.28 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.28 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.3 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.26 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.27 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.27 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.23 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.23 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.18 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.17 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.17 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.17 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.19 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.17 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.18 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.18 isoniazid
kasA 2518993 c.879C>G synonymous_variant 0.17 isoniazid
kasA 2518999 c.885G>A synonymous_variant 0.17 isoniazid
eis 2715507 c.-175G>A upstream_gene_variant 1.0 kanamycin
amikacin
Rv2477c 2782816 c.1227T>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782822 c.1221G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782828 c.1215T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.24 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.35 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.36 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.38 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.42 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.39 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.4 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.41 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.33 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.17 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.22 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.2 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.18 capreomycin
Rv2752c 3065451 c.741G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065463 c.729T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065523 c.669C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066315 c.-124C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067325 c.621A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067376 c.570G>A synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.36 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.39 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.39 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.4 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.4 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.37 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.38 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.39 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.33 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.36 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.31 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067736 p.Phe70Leu missense_variant 0.26 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.24 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.24 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074034 c.438T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624050 c.861C>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624077 c.834G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624086 c.825C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624124 p.Leu263Val missense_variant 0.17 rifampicin
bedaquiline
lpqB 3624143 c.768T>C synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624167 c.744C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625617 p.Arg333Gly missense_variant 0.18 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.24 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.24 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.18 rifampicin
bedaquiline
rpoA 3877553 p.Glu319Gln missense_variant 0.18 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.22 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.27 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.3 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.32 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.33 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.32 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.36 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.37 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.35 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.34 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.35 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.34 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.34 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.35 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.37 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.35 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.32 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.31 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.31 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.31 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.31 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.31 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.31 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.32 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.33 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.36 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>G synonymous_variant 0.35 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.36 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.35 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.35 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.35 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.32 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.3 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.36 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.34 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.34 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.32 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.37 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.4 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.41 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.41 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.41 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.43 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.45 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.46 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.43 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.42 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.38 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.39 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.38 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.38 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.38 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.35 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.35 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.36 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.34 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.32 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.29 rifampicin
rpoA 3878683 c.-176G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.4 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.37 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.37 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.37 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.39 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.39 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.38 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.36 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.39 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.39 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.39 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.28 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.29 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.25 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.27 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.23 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.28 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.28 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.24 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.23 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.24 rifampicin
clpC1 4038433 c.2272C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.17 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.17 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.17 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.23 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.23 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.23 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.33 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.27 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.29 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.34 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.33 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.27 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.2 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.19 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.18 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.27 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.28 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.22 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.28 pyrazinamide
clpC1 4040210 c.495G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.29 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.31 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.3 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.3 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.3 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.29 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.23 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040501 c.204C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138646 c.1110G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138654 c.1102C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138721 c.1035G>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138730 c.1026C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139420 c.336T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139432 c.324C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139447 p.His103Lys missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139450 c.306G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139453 c.303T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139459 c.297A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139474 c.282T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139477 c.279A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139483 c.273C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139486 c.270T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139489 c.267G>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139494 c.262T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139504 p.Asp84Asn missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139515 p.Ser81Ala missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139516 c.240A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139524 p.Thr78Ala missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol
glpK 4139526 p.Ala77Arg missense_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139537 c.219G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139541 p.Ile72Thr missense_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139545 c.211T>C synonymous_variant 0.27 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139552 p.Ala68Ser missense_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139601 p.Arg52Gln missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240642 c.780G>C synonymous_variant 0.17 ethambutol
embC 4240654 c.792C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240660 c.798C>G synonymous_variant 0.18 ethambutol
embC 4240669 c.807G>C synonymous_variant 0.18 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.17 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.17 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.18 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.26 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.26 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.26 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.24 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.19 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.19 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.19 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.19 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.19 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.18 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.18 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.18 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.18 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTTG synonymous_variant 0.19 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.18 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.18 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.18 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.18 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.18 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.18 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.19 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.2 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.2 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.2 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.19 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.19 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.19 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.18 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241170 c.1308G>C synonymous_variant 0.19 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.2 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.18 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241521 c.1659T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>A synonymous_variant 0.19 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.19 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.19 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.19 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.2 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.21 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.22 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.22 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.24 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.21 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.21 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.21 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.2 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.2 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.94 ethambutol Not assoc w R
embA 4245198 p.Leu656Ile missense_variant 0.17 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.18 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.19 ethambutol
embA 4245248 c.2016G>C synonymous_variant 0.19 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.17 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.17 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.19 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.19 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.17 ethambutol
embB 4248011 p.Ser500Pro missense_variant 0.17 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.18 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.2 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.21 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.21 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.21 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.23 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.2 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.23 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.23 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.23 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.23 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.23 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.23 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.29 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.28 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.29 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.29 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.3 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.17 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407925 p.Pro93Gln missense_variant 0.99 streptomycin Uncertain significance