TB-Profiler result

Run: ERR9786076
Summary

Run ID: ERR9786076

Sample name:

Date: 2024-04-13T21:51:04.487659

Number of reads: 1829329

Percentage reads mapped: 55.47

Median coverage: 84.0

Strain: lineage3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1305494 c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN frameshift_variant&stop_lost&splice_region_variant 1.0 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9017 c.1716C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760496 c.690G>T synonymous_variant 0.19 rifampicin
rpoB 760508 c.702G>C synonymous_variant 0.23 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.24 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.27 rifampicin Uncertain significance
rpoB 760527 p.Gln241Glu missense_variant 0.26 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760534 p.Val243Ala missense_variant 0.25 rifampicin
rpoB 760541 c.735G>T synonymous_variant 0.25 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.28 rifampicin Uncertain significance
rpoB 760568 c.762G>C synonymous_variant 0.28 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.28 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.3 rifampicin
rpoB 760596 p.Thr264Gln missense_variant 0.3 rifampicin
rpoB 760607 c.801G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoB 760616 c.810C>T synonymous_variant 0.28 rifampicin
rpoB 760625 c.819C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760629 c.823C>T synonymous_variant 0.3 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760658 c.852G>A synonymous_variant 0.27 rifampicin
rpoB 760661 c.855A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.26 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>C synonymous_variant 0.16 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>T synonymous_variant 0.17 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761289 p.Ser495Ala missense_variant 0.14 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.15 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.15 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762020 p.Glu738Asp missense_variant 0.15 rifampicin
rpoB 762026 c.2220G>C synonymous_variant 0.15 rifampicin
rpoB 762041 c.2235C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762104 c.2298C>T synonymous_variant 0.27 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.28 rifampicin Uncertain significance
rpoB 762137 c.2331C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.29 rifampicin
rpoB 762161 c.2355C>G synonymous_variant 0.3 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762221 c.2415G>A synonymous_variant 0.28 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.26 rifampicin
rpoB 762266 c.2460T>G synonymous_variant 0.27 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.26 rifampicin
rpoB 762290 c.2484C>T synonymous_variant 0.26 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762305 c.2499G>T synonymous_variant 0.23 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.16 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.14 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.15 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 762879 p.Met1025Leu missense_variant 0.17 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.25 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762998 c.-372G>A upstream_gene_variant 0.24 rifampicin
rpoB 763004 c.3198G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763049 c.-321G>A upstream_gene_variant 0.33 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.33 rifampicin
rpoC 763079 c.-291C>G upstream_gene_variant 0.33 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763124 c.-246C>T upstream_gene_variant 0.25 rifampicin
rpoC 763139 c.-231C>T upstream_gene_variant 0.24 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.24 rifampicin
rpoB 763145 c.3339G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.17 rifampicin
rpoB 763206 p.Ser1134Cys missense_variant 0.12 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763453 c.84C>T synonymous_variant 0.13 rifampicin
rpoC 763459 c.90G>A synonymous_variant 0.13 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763505 c.136C>T synonymous_variant 0.21 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.2 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.2 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.2 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.2 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763597 c.228G>A synonymous_variant 0.22 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763651 c.282C>T synonymous_variant 0.18 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764005 c.636G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.14 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.14 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.14 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.16 rifampicin
rpoC 764077 c.708C>G synonymous_variant 0.14 rifampicin
rpoC 764084 c.715_717delAACinsGG frameshift_variant&missense_variant 0.12 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764102 c.733_735delGTCinsCG frameshift_variant&missense_variant 0.12 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.16 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764146 c.777G>A synonymous_variant 0.14 rifampicin
rpoC 764149 c.780G>C synonymous_variant 0.14 rifampicin
rpoC 764164 p.Ile265Met missense_variant 0.13 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.13 rifampicin
rpoC 764344 c.975C>G synonymous_variant 0.16 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.19 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.21 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.19 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.22 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.26 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.26 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.22 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.21 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.19 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.2 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764680 c.1311G>A synonymous_variant 0.18 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.21 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764779 c.1410G>A synonymous_variant 0.22 rifampicin
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.23 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.24 rifampicin
rpoC 764809 c.1440C>G synonymous_variant 0.23 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.22 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 0.21 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.2 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 764908 c.1539G>A synonymous_variant 0.15 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.14 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.14 rifampicin Uncertain significance
rpoC 764926 c.1557C>T synonymous_variant 0.16 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.14 rifampicin
rpoC 764947 c.1578G>A synonymous_variant 0.13 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765781 c.2412C>T synonymous_variant 0.14 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.15 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.15 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.15 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>T synonymous_variant 0.17 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.17 rifampicin
rpoC 765820 c.2451G>C synonymous_variant 0.18 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.18 rifampicin
rpoC 765826 c.2457T>G synonymous_variant 0.18 rifampicin
rpoC 765835 c.2466C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765844 c.2475C>G synonymous_variant 0.17 rifampicin
rpoC 765871 c.2502T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.18 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765907 c.2538G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.17 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.14 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.13 rifampicin
rpoC 765955 c.2586C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766372 c.3003G>A synonymous_variant 0.14 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.15 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.15 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.16 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.16 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.18 rifampicin
rpoC 766429 c.3061_3062insCGG disruptive_inframe_insertion 0.18 rifampicin
rpoC 766435 p.Glu1022Asp missense_variant 0.17 rifampicin Uncertain significance
rpoC 766447 c.3078T>C synonymous_variant 0.22 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.22 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.23 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.22 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.22 rifampicin
rpoC 766489 c.3120G>C synonymous_variant 0.23 rifampicin
rpoC 766490 p.Arg1041Lys missense_variant 0.23 rifampicin
rpoC 766501 c.3132G>C synonymous_variant 0.24 rifampicin
rpoC 766513 p.Asp1048Glu missense_variant 0.25 rifampicin
rpoC 766517 c.3148_3150delACCinsTG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 766525 c.3156G>C synonymous_variant 0.25 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.25 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.27 rifampicin
rpoC 766542 p.Gly1058Asp missense_variant 0.27 rifampicin
rpoC 766546 p.Glu1059Asp missense_variant 0.27 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.25 rifampicin
rpoC 766568 c.3199_3201delGTTinsAC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.25 rifampicin
rpoC 766576 c.3207C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.25 rifampicin
rpoC 766588 p.Glu1073Asp missense_variant 0.23 rifampicin Uncertain significance
rpoC 766607 p.Ile1080Leu missense_variant 0.2 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.18 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.2 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.21 rifampicin
rpoC 766645 p.Glu1092Asp missense_variant 0.19 rifampicin Not assoc w R
rpoC 766657 c.3288A>G synonymous_variant 0.17 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.16 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.16 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.17 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.16 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.14 rifampicin
rpoC 766700 c.3331C>T synonymous_variant 0.14 rifampicin
rpoC 766703 p.Met1112Leu missense_variant 0.14 rifampicin
rpoC 766712 p.Ser1115Ala missense_variant 0.15 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.15 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.15 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.15 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.16 rifampicin
rpoC 766742 p.Gln1125Met missense_variant 0.16 rifampicin
rpoC 766753 c.3384C>G synonymous_variant 0.17 rifampicin
rpoC 766754 p.Glu1129Gln missense_variant 0.17 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766768 c.3399C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.19 rifampicin
rpoC 766776 p.Arg1136His missense_variant 0.19 rifampicin
rpoC 766780 c.3411G>A synonymous_variant 0.19 rifampicin
rpoC 766799 c.3430_3432delGCCinsTG frameshift_variant&missense_variant 0.2 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766813 c.3444G>C synonymous_variant 0.2 rifampicin
rpoC 766837 c.3468G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766876 c.3507C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766883 c.3514_3516delTCGinsGC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 766888 c.3519G>C synonymous_variant 0.14 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.14 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.14 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.15 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.15 rifampicin
rpoC 766909 c.3540G>C synonymous_variant 0.15 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.15 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.16 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.16 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.16 rifampicin
rpoC 766934 p.Glu1189Ser missense_variant 0.16 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766948 c.3579G>C synonymous_variant 0.17 rifampicin
rpoC 766951 c.3582G>C synonymous_variant 0.18 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.17 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.17 rifampicin
rpoC 767071 c.3702C>G synonymous_variant 0.17 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.17 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.15 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.14 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.14 streptomycin
rpsL 781709 c.150G>T synonymous_variant 0.14 streptomycin
rpsL 781714 c.156_157delTG frameshift_variant 0.14 streptomycin Uncertain significance
rpsL 781718 c.159C>G synonymous_variant 0.14 streptomycin
rpsL 781723 c.166_168delAAG conservative_inframe_deletion 0.14 streptomycin
rpsL 781728 c.170_171insCGCCT frameshift_variant 0.14 streptomycin Uncertain significance
rpsL 781733 c.174G>C synonymous_variant 0.14 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.14 streptomycin
rpsL 781737 p.Gln60Ala missense_variant 0.14 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.15 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.16 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.17 streptomycin Not assoc w R - Interim
rpsL 781769 c.210G>A synonymous_variant 0.18 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.17 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.17 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.16 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.16 streptomycin
rpsL 781829 c.270G>T synonymous_variant 0.15 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.15 streptomycin
rplC 800636 c.-173C>T upstream_gene_variant 0.94 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302982 p.Pro18Ala missense_variant 1.0 clofazimine
pretomanid
delamanid
Rv1258c 1406968 c.372delT frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1414586 c.-7_*1594del transcript_ablation 1.0 ethambutol Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471914 n.69A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471943 n.98T>C non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471978 n.133C>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.185_188delGGGA non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472057 n.212C>A non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472068 n.223T>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472069 n.224G>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472070 n.225G>A non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472278 n.433C>T non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>A non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472288 n.443A>T non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsAA non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472326 n.481T>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472330 n.485G>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472425 n.580T>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472437 n.592T>A non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472467 n.622G>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472486 n.641A>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472844 n.999C>A non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472845 n.1000G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472855 n.1011_1012insGT non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472861 n.1016_1018delGTTinsC non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.64 streptomycin Not assoc w R
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473828 n.171_176delGGTGCGinsCTGGTGT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsCA non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631_637delCCTTTTCinsTTGCACAGCTTG non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474296 n.640_647delCTCCGGAG non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474415 n.759_781delCACACGCGCATACGCGCGTGTGA non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474440 n.783T>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474444 n.787G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474662 n.1005C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474664 n.1007G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474666 n.1009T>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474670 n.1013C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474679 n.1022G>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474684 n.1027T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474687 n.1030C>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474688 n.1031G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474711 n.1054_1055insA non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474714 n.1058delT non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475615 n.1958C>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475735 n.2078T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475791 n.2134A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475892 n.2235A>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.51 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.51 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476758 n.3101G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rpsA 1833727 c.186G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833734 c.193_195delGCCinsTT frameshift_variant&missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833742 c.201A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833754 c.213G>A synonymous_variant 0.14 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1833769 c.228C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833859 c.318C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.25 pyrazinamide
rpsA 1833919 c.378C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1833920 p.Lys127Arg missense_variant 0.3 pyrazinamide
rpsA 1833928 c.387G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833931 c.390C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833964 c.423C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1833970 c.429G>T synonymous_variant 0.33 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.34 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.32 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.32 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834144 c.603G>A synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834151 c.610_612delAATinsCC frameshift_variant&missense_variant 0.22 pyrazinamide Uncertain significance
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834167 c.628_629delAC frameshift_variant 0.22 pyrazinamide Uncertain significance
rpsA 1834172 c.631_632insGG frameshift_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834273 c.732C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834279 c.738C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834298 p.Gln253Glu missense_variant 0.27 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834307 p.Asp256Asn missense_variant 0.26 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.26 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834345 c.804C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834375 c.834G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.32 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.27 pyrazinamide Uncertain significance
rpsA 1834465 c.924T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.18 pyrazinamide
rpsA 1834557 p.Ala339Val missense_variant 0.18 pyrazinamide
rpsA 1834591 c.1050C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834650 p.Thr370Ser missense_variant 0.15 pyrazinamide
rpsA 1834652 p.Glu371Pro missense_variant 0.16 pyrazinamide
rpsA 1834663 c.1122C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.17 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.18 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.99 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.99 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
ribD 2986852 p.Gly5Asp missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612068 p.Gly350Glu missense_variant 1.0 pyrazinamide Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877613 p.Ile299Val missense_variant 0.16 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.17 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877653 c.855C>T synonymous_variant 0.18 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.19 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877674 c.834C>G synonymous_variant 0.18 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877716 c.792C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877731 c.777G>T synonymous_variant 0.22 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.23 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.23 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.24 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.25 rifampicin
rpoA 3877764 p.Ala248Gly missense_variant 0.26 rifampicin
rpoA 3877770 c.738A>C synonymous_variant 0.27 rifampicin
rpoA 3877773 c.735G>C synonymous_variant 0.27 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877797 c.711G>C synonymous_variant 0.28 rifampicin
rpoA 3877800 c.708G>C synonymous_variant 0.27 rifampicin
rpoA 3877803 c.705G>C synonymous_variant 0.27 rifampicin
rpoA 3877815 c.693C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877824 c.684G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877833 c.675C>G synonymous_variant 0.25 rifampicin
rpoA 3877839 c.669G>T synonymous_variant 0.24 rifampicin
rpoA 3877842 c.666A>C synonymous_variant 0.24 rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.22 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.23 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.23 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 0.23 rifampicin
rpoA 3877884 c.624G>C synonymous_variant 0.23 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.25 rifampicin
rpoA 3877898 p.Pro204Ala missense_variant 0.26 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.28 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.31 rifampicin
rpoA 3877932 c.576G>C synonymous_variant 0.32 rifampicin
rpoA 3877936 p.Lys191Arg missense_variant 0.33 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.26 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.26 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.18 rifampicin
rpoA 3878016 c.492C>G synonymous_variant 0.15 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.15 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.15 rifampicin
rpoA 3878025 c.483C>G synonymous_variant 0.16 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.16 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.16 rifampicin
rpoA 3878037 c.471C>G synonymous_variant 0.16 rifampicin
rpoA 3878043 c.463_465delTCGinsAC frameshift_variant&missense_variant 0.15 rifampicin
rpoA 3878046 c.462T>G synonymous_variant 0.17 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.15 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.18 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.19 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.19 rifampicin
rpoA 3878085 c.423G>A synonymous_variant 0.19 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.19 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.18 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.18 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.18 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.16 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.14 rifampicin
rpoA 3878136 c.372C>T synonymous_variant 0.14 rifampicin
clpC1 4038773 c.1932T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.22 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 0.33 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.33 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.33 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.36 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.37 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.37 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038962 c.1743C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038997 c.1708T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039010 c.1695G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039082 c.1623C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.3 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.34 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039178 c.1527G>T synonymous_variant 0.34 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCC frameshift_variant&missense_variant 0.33 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.32 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.33 pyrazinamide
clpC1 4039217 c.1488G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039239 p.Gly489Ala missense_variant 0.29 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039327 p.Gln460Lys missense_variant 0.19 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.19 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.2 pyrazinamide
clpC1 4039347 p.Arg453Lys missense_variant 0.19 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039360 p.Ser449Arg missense_variant 0.2 pyrazinamide
clpC1 4039361 c.1344C>A synonymous_variant 0.2 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039394 c.1309_1311delTCGinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039427 p.Glu426Asp missense_variant 0.22 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039472 c.1233G>T synonymous_variant 0.21 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039487 c.1218G>A synonymous_variant 0.22 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039553 c.1152C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039570 c.1135delAinsCCC frameshift_variant&missense_variant 0.31 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039598 c.1107C>T synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039628 c.1077C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039634 c.1069_1071delGAGinsAC frameshift_variant&missense_variant 0.34 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039700 c.1005C>T synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039715 c.990G>A synonymous_variant 0.35 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.28 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039835 c.870C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039862 c.843C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039874 c.831C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.3 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.23 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040015 c.690G>T synonymous_variant 0.23 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040381 c.324T>C synonymous_variant 0.12 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.13 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.13 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040474 c.231C>T synonymous_variant 0.16 pyrazinamide
clpC1 4040477 c.228G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>T synonymous_variant 0.14 pyrazinamide
panD 4044905 c.-624C>T upstream_gene_variant 1.0 pyrazinamide
embC 4240355 p.Ala165Thr missense_variant 1.0 ethambutol Uncertain significance
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4268528 c.309C>T synonymous_variant 1.0 ethambutol
whiB6 4338471 p.Arg17Ser missense_variant 1.0 capreomycin
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R